Paeoniflorin

Name	AC	CK	Focus
Depression	1	1

Name	AC	CK	Focus
Antidepressive Agents	1	1
Gastrointestinal Agents	1	1

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

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Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2021

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Pubmed Data : Int J Med Sci. 2022 ;19(4):681-694. Epub 2022 Mar 28. PMID: 35582418

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Paeoniflorin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.Dec 31, 2021

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Pubmed Data : Heliyon. 2022 Dec ;8(12):e12312. Epub 2022 Dec 15. PMID: 36590561

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6623464. Epub 2021 Apr 7. PMID: 33880124

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Pubmed Data : Biomed Pharmacother. 2016 May ;80:200-206. Epub 2016 Mar 28. PMID: 27133057

Article Published Date : Apr 30, 2016

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity, Sepsis, Septic Shock

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin exerts a nephroprotective effect on concanavalin A-induced damage.Jul 24, 2015

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Pubmed Data : Diagn Pathol. 2015 Jul 25 ;10:120. Epub 2015 Jul 25. PMID: 26204936

Article Published Date : Jul 24, 2015

Study Type : Animal Study

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Substances : Paeoniflorin

Pharmacological Actions : Renoprotective

Problem Substances : Concanavalin A

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Paeoniflorin exerts a neuroprotective effect in model of dementia.Dec 31, 2017

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Pubmed Data : Chin Med. 2018 ;13:14. Epub 2018 Mar 20. PMID: 29560022

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Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:152-160. Epub 2017 Jun 27. PMID: 28666238

Article Published Date : Aug 31, 2017

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Inflammation, Ulcerative Colitis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-10 downregulation, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-2 Downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin improved constipation in the loperamide-induced model.Dec 31, 2020

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Pubmed Data : PeerJ. 2021 ;9:e10921. Epub 2021 May 28. PMID: 34123580

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Brain Inflammation , Stroke

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress.Dec 31, 2014

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Pubmed Data : Food Chem Toxicol. 2012 May ;50(5):1560-7. Epub 2012 Feb 2. PMID: 22326807

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Pubmed Data : Inflammopharmacology. 2019 Jul 15. Epub 2019 Jul 15. PMID: 31309485

Article Published Date : Jul 14, 2019

Study Type : Insect Study

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Substances : Paeoniflorin

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3.May 31, 2018

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Pubmed Data : Exp Parasitol. 2019 Feb ;197:85-92. Epub 2018 Nov 8. PMID: 30414842

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Liver Disease, Schistosomiasis

Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic, Vascular Endothelial Growth Factor Inhibitors

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Paeoniflorin may be a potential neuroprotective agent for stroke.Dec 31, 2014

Pubmed Data : Neurochem Res. 2015 Aug ;40(8):1583-92. Epub 2015 Jun 12. PMID: 26068144

Article Published Date : Jul 31, 2015

Study Type : Transgenic Animal Study

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Substances : Paeoniflorin

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation.Dec 31, 2021

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Pubmed Data : Molecules. 2022 Dec 4 ;27(23). Epub 2022 Dec 4. PMID: 36500627

Article Published Date : Dec 03, 2022

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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Paeoniflorin protects against concanavalin A-induced hepatitis.Dec 31, 2014

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Pubmed Data : Int Immunopharmacol. 2015 Jan ;24(1):42-9. Epub 2014 Nov 20. PMID: 25479726

Paeoniflorin protects diabetic mice against myocardial ischemic injury.Dec 31, 2015

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Paeoniflorin supplementation has potent protective efficiency against neonatal hypoxia/ischemia-induced brain injury.Feb 28, 2021

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Pubmed Data : Korean J Physiol Pharmacol. 2021 Mar 1 ;25(2):97-109. PMID: 33602880

Article Published Date : Feb 28, 2021

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Brain: Oxidative Stress, Brain Hypoxia, Brain Injury: Traumatic

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Pubmed Data : Chem Biodivers. 2022 Jul 16. Epub 2022 Jul 16. PMID: 35841592

Article Published Date : Jul 15, 2022

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Colitis, Colorectal Cancer

Pharmacological Actions : Chemopreventive

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Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel.Feb 14, 2017

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Pubmed Data : Phytomedicine. 2017 Feb 15 ;25:1-7. Epub 2016 Dec 19. PMID: 28190463

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Pubmed Data : Am J Chin Med. 2010 ;38(1):51-64. PMID: 20128044

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Pubmed Data : Inflammopharmacology. 2020 Jun 28. Epub 2020 Jun 28. PMID: 32596762

Article Published Date : Jun 27, 2020

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Inflammation, Neuropathic Pain

Pharmacological Actions : Anti-Inflammatory Agents

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Paeoniflorin inhibits MRGPRX2-mediated pseudo-allergic reaction via calcium signaling pathway.Jan 31, 2020

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Pubmed Data : Phytother Res. 2020 Feb ;34(2):401-408. Epub 2019 Oct 31. PMID: 31667930

Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:944386. Epub 2022 Sep 7. PMID: 36160378

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Neuropathic Pain

Pharmacological Actions : Hypolipidemic

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Pubmed Data : Fitoterapia. 2014 Dec ;99:318-27. Epub 2014 Oct 16. PMID: 25454463

Article Published Date : Nov 30, 2014

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Liver Cirrhosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

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Pubmed Data : Inflammation. 2013 Feb ;36(1):216-25. PMID: 23053726

Article Published Date : Jan 31, 2013

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Lipopolysaccharide-Induced Toxicity

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Pubmed Data : J Ethnopharmacol. 2019 Jan 30 ;229:97-103. Epub 2018 Sep 5. PMID: 30195059

Article Published Date : Jan 29, 2019

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Polycystic Ovary Syndrome, Testosterone: Too High

Problem Substances : Dexamethasone

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Paeoniflorin has a beneficial effect on asthma.Dec 31, 2017

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Pubmed Data : Front Pharmacol. 2018 ;9:1531. Epub 2019 Jan 18. PMID: 30761008

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Asthma

Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents, Antioxidants

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Paeoniflorin has a promising therapeutic potential in for osteosarcoma.Mar 31, 2018

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Pubmed Data : Asian Pac J Cancer Prev. 2021 Dec 1 ;22(12):3949-3958. Epub 2021 Dec 1. PMID: 34967576

Article Published Date : Nov 30, 2021

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Breast Cancer, Cancers: Drug Resistant

Pharmacological Actions : Antineoplastic Agents, Chemosensitizer

Additional Keywords : Synergy with Tamoxifen

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Paeoniflorin improves the in vitro maturation of benzo(a)pyrene treated porcine oocytes via effects on the sonic hedgehog pathway.Feb 28, 2022

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Pubmed Data : Theriogenology. 2022 Mar 1 ;180:72-81. Epub 2021 Dec 17. PMID: 34953351

Article Published Date : Feb 28, 2022

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Benzo[a]pyrene-induced Toxicity

Pharmacological Actions : Cytoprotective

Problem Substances : Benzo(a)pyrene

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Paeoniflorin improves the permeability of cardiac microvascular endothelial cells.Dec 31, 2019

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Pubmed Data : Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020 Jan ;32(1):83-87. PMID: 32148237

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis

Pharmacological Actions : Cardioprotective

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Pubmed Data : J Cell Biochem. 2018 Nov ;119(10):8636-8642. Epub 2018 Aug 4. PMID: 30076630

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin inhibits proliferation and induces apoptosis of human glioma cells.Jul 31, 2015

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Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):5445-5451. Epub 2017 Oct 2. PMID: 29285074

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Endometrial Cancer

Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor

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Paeoniflorin inhibits the macrophage-related rosacea-like inflammatory reaction.Jan 21, 2021

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Paeoniflorin may be a potential agent in the future treatment of osteoarthritis.Jan 31, 2018

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Pubmed Data : J Cell Biochem. 2018 Oct 28. Epub 2018 Oct 28. PMID: 30368886

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Pubmed Data : Food Funct. 2018 Apr 25 ;9(4):2386-2397. PMID: 29594285

Article Published Date : Apr 24, 2018

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Endothelial Dysfunction, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Paeoniflorin modulates multidrug resistance of a human gastric cancer cell line via the inhibition of NF-κB activation.Jan 31, 2012

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Pubmed Data : Mol Med Rep. 2012 Feb ;5(2):351-6. Epub 2011 Nov 1. PMID: 22051979

Article Published Date : Jan 31, 2012

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Cancers: Multi-Drug Resistant, Gastric Cancer

Pharmacological Actions : Bcl-2 protein down-regulation, Multidrug Resistance Gene Modulators, NF-kappaB Inhibitor

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Paeoniflorin potentiates the inhibitory effects of erlotinib in pancreatic cancer cell linesJan 08, 2016

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Pubmed Data : Sci Rep. 2016 09 9 ;6:32809. Epub 2016 Sep 9. PMID: 27609096

Article Published Date : Jan 08, 2016

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Chemotherapeutic Synergy: Erlotinib

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Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy.Jul 23, 2017

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Paeoniflorin sensitizes breast cancer cells to tamoxifen.Dec 31, 2020

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Pubmed Data : Drug Des Devel Ther. 2021 ;15:245-257. Epub 2021 Jan 22. PMID: 33519190

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:4304790. Epub 2022 Nov 5. PMID: 36387364

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

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The current study provided a molecular base for the potential use of paeoniflorin in therapeutic treatment of sepsis induced by bacterial lipoprotein.Dec 31, 2013

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Pubmed Data : Cent Eur J Immunol. 2014 ;39(4):461-7. Epub 2014 Dec 15. PMID: 26155163

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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The effects of total glucosides of paeony and paeoniflorin on inflammatory-immune responses in rheumatoid arthritis.Dec 31, 2018

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Pubmed Data : Funct Plant Biol. 2019 Jan ;46(2):107-117. PMID: 32172753

Article Published Date : Dec 31, 2018

Study Type : Review

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Substances : Paeoniflorin, Paeonol

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

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View the Evidence: 311 Abstracts with Paeoniflorin Research

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Efficacy of paeoniflorin on models of depression.Feb 06, 2022

Paeoniflorin may provide a new therapeutic approach to regulate P2X7R-mediated pathologic responses of primary Sjögren's syndrome.Aug 31, 2015

Paeoniflorin ameliorates diabetic liver injury.Apr 24, 2022

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2021

Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.Dec 31, 2021

Paeoniflorin ameliorates depressive-like behavior in prenatally stressed offspring by restoring the HPA axis- and glucocorticoid receptor- associated dysfunction.Aug 31, 2020

Paeoniflorin inhibits IgE-mediated allergic reactions by suppressing the degranulation of mast cells though binding with FcɛRI alpha subunits.Aug 05, 2020

Angiogenic actions of paeoniflorin on endothelial progenitor cells and in ischemic stroke model.Apr 06, 2021

Anticonvulsive effect of paeoniflorin on experimental febrile seizures.Dec 31, 2011

Antidepressant effect of paeoniflorin Is through inhibiting pyroptosis CASP-11/GSDMD pathway.Oct 05, 2020

Application of paeoniflorin represents a novel therapeutic approach for the treatment of cutaneous wounds.Jun 14, 2020

Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia.Jan 14, 2018

Circadian pharmacological effects of paeoniflorin on mice With urticaria-like lesions.Dec 31, 2020

Effect of paeoniflorin on acute lung injury induced by influenza A virus.Oct 31, 2021

Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model.Oct 04, 2019

Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain.Apr 10, 2019

Inhibitory effect of paeoniflorin on IgE-dependent and IgE-independent mast cell degranulation in vitro and vivo.Jun 30, 2021

Mechanism of paeoniflorin on ANIT-induced cholestatic liver injury using integrated metabolomics and network pharmacology.Dec 31, 2020

Mechanism of paeonol combined with paeoniflorin against myocardial ischemia injury.Jul 31, 2021

Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel promotes diabetic wound healing.Aug 31, 2021

Network pharmacology-based and experimental identification of the effects of paeoniflorin on major depressive disorder.Dec 31, 2020

Neuroprotection by paeoniflorin in the MPTP mouse model of Parkinson's disease.Dec 31, 2016

Neuroprotective effect of paeoniflorin in the mouse model of Parkinson's disease.Dec 07, 2021

Nrf2-dependent protective effect of paeoniflorin on α-naphthalene isothiocyanate-induced hepatic injury.Dec 31, 2021

Oral administration of paeoniflorin attenuates allergic contact dermatitis.Mar 31, 2015

Paeonia lactiflora reduced cerebral ischemia and arterial intimal hyperplasia.Dec 31, 2012

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.Dec 31, 2013

Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway.Nov 25, 2021

Paeoniflorin alleviates H2O2-Induced oxidative injury through down-regulation of microRNA-135a in HT-22 cells.Nov 13, 2019

Paeoniflorin alleviates inflammatory response in IBS-D mouse model.Nov 30, 2022

Paeoniflorin alleviates lipopolysaccharide-induced disseminated intravascular coagulation.May 31, 2020

Paeoniflorin alleviates liver injury in hypercholesterolemia.Dec 31, 2021

Paeoniflorin alleviates non-alcoholic steatohepatitis.Aug 31, 2016

Paeoniflorin alleviates skeletal muscle atrophy in ovariectomized mice.Mar 22, 2022

Paeoniflorin alleviates the progression of retinal vein occlusion.Apr 30, 2022

Paeoniflorin ameliorates acute myocardial infarction.Aug 31, 2015

Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitis‑induced acute renal injury.Jul 31, 2016

Paeoniflorin ameliorates Adriamycin-induced nephrotic syndrome.Nov 30, 2017

Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice.Oct 29, 2021

Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia.Jul 14, 2020

Paeoniflorin ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension.Dec 31, 2019

Paeoniflorin ameliorates chronic stress-induced depression-like behavior.Jan 11, 2021

Paeoniflorin ameliorates chronic stress-induced depression-like behaviours and neuronal damages.Dec 31, 2017

Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling.Feb 28, 2022

Paeoniflorin ameliorates colonic fibrosis in rats with postinfectious irritable bowel syndrome.Dec 31, 2021

Paeoniflorin ameliorates experimental autoimmune encephalomyelitis.Jan 05, 2017

Paeoniflorin ameliorates fructose-induced insulin resistance and hepatic steatosis.Aug 04, 2018

Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviours.Jan 30, 2017

Paeoniflorin ameliorates ischemic injury.May 10, 2021

Paeoniflorin ameliorates lipopolysaccharide-induced acute liver injury.May 15, 2022

Paeoniflorin ameliorates liver injury of MRL/lpr mice through inhibition of NF-κB pathway.Oct 31, 2017

Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors.Apr 30, 2021

Paeoniflorin ameliorates oxidase stress in Glutamate-stimulated SY5Y and prenatally stressed female offspring.Jul 16, 2021

Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression.Dec 31, 2015

Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17/Treg balanceMay 28, 2020

Paeoniflorin and albiflorin are potential therapeutic agents for neuropathic pain, which merit further investigation.Dec 31, 2015

Paeoniflorin and albiflorin may promote the recovery of bone marrow hemopoietic function in a myelosuppression model.Dec 31, 2015

Paeoniflorin and astragaloside IV alleviate ischemic brain edema.Aug 31, 2017

Paeoniflorin as a promising therapeutic agent for treating diabetic nephropathy.Dec 31, 2018

Paeoniflorin attenuated oxidative stress in a COPD model induced by cigarette smoke.Dec 31, 2015

Paeoniflorin attenuates cerebral ischemia-induced injury.Feb 26, 2017

Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage.May 16, 2006

Paeoniflorin attenuates depressive behaviors in systemic lupus erythematosus.Jun 30, 2018

Paeoniflorin attenuates dexamethasone-induced apoptosis of osteoblast cells and promotes bone formation.Dec 31, 2020

Paeoniflorin attenuates dextran sulfate sodium-induced ulcerative colitis in mice by inhibiting TLR5 expression and T cell activation.Jul 31, 2020

Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome.Feb 25, 2021

Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage.Apr 02, 2020

Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia.Nov 30, 2016

Paeoniflorin attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response.Jul 31, 2013

Paeoniflorin attenuates myocardial fibrosis in isoprenaline-induced chronic heart failure.Mar 31, 2020

Paeoniflorin attenuates postoperative pain by suppressing matrix metalloproteinase-9/2 in mice.Dec 31, 2017

Paeoniflorin attenuates pressure overload-induced cardiac remodeling.May 31, 2013

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View the Evidence:
311 Abstracts with Paeoniflorin Research