Paeonol

Name	AC	CK
Inflammation	15	26
Lipopolysaccharide-Induced Toxicity	13	20
Atherosclerosis	12	16
Oxidative Stress	6	11
Ulcerative Colitis	5	11
Liver Cancer	7	9
Chemotherapy-Induced Toxicity: Epirubicin	4	7
Alzheimer's Disease	4	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	6
Colitis	3	6
Diabetic Complications	3	6
Drug Toxicity: Methotrexate	3	6
Endothelial Dysfunction	4	6
Gastric Cancer	5	6
Hypoxia	3	6
Liver Damage: Drug-Induced	3	6
Liver Fibrosis	3	6
Osteoarthritis	3	6
Cardiovascular Diseases	5	5
Chemically-Induced Liver Damage	3	5
Heart Failure	3	5
Rheumatoid Arthritis	3	5
Alcoholic Liver Disease	2	4
Brain Inflammation	3	4
Breast Cancer	3	4
Cancers: All	3	4
Candida Albicans	3	4
Chemotherapy-Induced Kidney Damage	2	4
Depression	2	4
Diabetic Nephropathy	2	4
Fibrosis	2	4
Hypertension	2	4
Lipid Peroxidation	3	4
Lung Cancer	3	4
Lung Injury: Acute	2	4
Myocardial Ischemia	2	4
Pancreatitis	2	4
Parkinson's Disease	3	4
Periodontitis	2	4
Pseudomonas aeruginosa	2	4
Stroke: Ischemic	2	4
Ultraviolet Radiation Induced Damage	2	4
Cancers: Drug Resistant	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Cardiomegaly	2	3
Endotoxemia	2	3
Hyperlipidemia	2	3
Melanoma	2	3
Myocardial Infarction	1	3
Neurodegenerative Diseases	2	3
Psoriasis	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Aeromonas hydrophila	1	2
Aging Skin	1	2
Aging: Brain	1	2
Aneurysm: Aortic	1	2
Arthritis	1	2
Asthma	1	2
Bladder Cancer	1	2
Brain Hemorrhage: Cerebral	1	2
Brain: Microglial Activation	2	2
C-Reactive Protein	1	2
Cancer Metastasis	1	2
Cardiac Hypertrophy	1	2
Cerebral Ischemia	1	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Cholesterol: Oxidation	2	2
Cognitive Decline/Dysfunction	1	2
Colorectal Cancer	2	2
Dementia	1	2
Diabetes Mellitus: Type 2	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetic Ulcer	1	2
Diarrhea: Antibiotic-Associated	1	2
Dry Skin	1	2
Dysbiosis	1	2
Encephalopathy	1	2
Epilepsy	1	2
Erectile Dysfunction	1	2
Gastric Ulcer	1	2
High Fat Diet	1	2
Hypertension: Pulmonary	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Fibrosis	1	2
Liver Cirrhosis	1	2
Liver Failure: Acute	1	2
Liver Injury: Ischemia/reperfusion	1	2
Lung Inflammation	1	2
Memory Disorders	1	2
Migraines	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Oral Cancer	1	2
Osteoporosis	1	2
Ovarian Cancer	2	2
Porphyromonas gingivalis	1	2
Pre-Eclampsia	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Retinal Diseases	1	2
Schizophrenia	1	2
Spinal Cord Injuries	1	2
Amyotrophic lateral sclerosis (ALS)	1	1
Brain: Oxidative Stress	1	1
Cadmium Poisoning	1	1
Candidiasis	1	1
Cardiomyopathy	1	1
Cryptococcosis	1	1
Endometriosis	1	1
Enterobacteriaceae Infections	1	1
Esophageal Cancer	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hyperalgesia	1	1
Hyperglycemia	1	1
Kidney Cancer	1	1
Klebsiella Infections	1	1
Listeria Infections	1	1
Lupus Nephritis	1	1
Multiple Sclerosis	1	1
Neuropathic Pain	1	1
Obesity	1	1
Pancreatic Cancer	1	1
Prostate Cancer	1	1
Staphylococcus aureus infection	1	1

Name	AC	CK
Anti-Inflammatory Agents	68	119
Tumor Necrosis Factor (TNF) Alpha Inhibitor	34	58
Interleukin-1 beta downregulation	30	51
NF-kappaB Inhibitor	26	46
Antioxidants	27	45
Interleukin-6 Downregulation	22	38
Antiproliferative	26	33
Neuroprotective Agents	20	33
Anti-Apoptotic	19	32
Apoptotic	24	29
Cardioprotective	18	29
Hepatoprotective	12	23
MicroRNA modulator	12	18
Chemoprotective Agents	9	16
Gastrointestinal Agents	7	14
Nrf2 activation	7	13
Anti-Fibrotic	6	12
Anti-Bacterial Agents	7	11
Anti-metastatic	9	11
Renoprotective	5	9
Antineoplastic Agents	6	8
Heme oxygenase-1 up-regulation	4	8
Malondialdehyde Down-regulation	4	8
Superoxide Dismutase Up-regulation	4	8
Antihypertensive Agents	3	6
Hypolipidemic	3	5
Immunomodulatory	3	5
Transforming growth factor beta (TGF-β) inhibitor	3	5
Anti-Ulcer Agents	2	4
Antidepressive Agents	2	4
Bcl-2 protein down-regulation	4	4
Cyclooxygenase 2 Inhibitors	3	4
Quorum Sensing Inhibition	2	4
Anti-atherogenic	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	3
Postaglandin PGE2 downregulation	2	3
STAT3 Inhibitor	2	3
Analgesics	2	2
Anti-Angiogenic	1	2
Anti-Asthmatic Agents	1	2
Anticarcinogenic Agents	1	2
Antifungal Agents	2	2
Autophagy Up-regulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Cell cycle arrest	2	2
Chemosensitizer	1	2
Gastroprotective	1	2
Hypoglycemic Agents	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Interferon Gamma Reducer	1	2
Interleukin-10 upregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-23 Downregulation	1	2
Interleukin-4 upregulation	1	2
Nitric Oxide Inhibitor	1	2
Osteoprotective	1	2
Photoprotective	1	2
SIRT1 Activator	1	2
Vasodilator Agents	1	2
5-Lipoxygenase Inhibitor	1	1
Angiogenesis Inhibitors	1	1
Autophagy Inhibitors	1	1
Interleukin-10 downregulation	1	1
Interleukin-12 downregulation	1	1
Radiosensitizer	1	1
STAT3 Activation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Vasoprotective	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Paeonol alleviates ulcerative colitis by modulating PPAR-γ and nuclear factor-κB activation.Aug 07, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Nutr. 2022 ;9:846684. Epub 2022 Apr 13. PMID: 35495936

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Ulcerative Colitis

Pharmacological Actions : Gastrointestinal Agents, Gastroprotective, Transforming growth factor beta (TGF-β) inhibitor

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Paeonol a promising botanical in protecting skin from UVB-induced photoaging.Aug 31, 2018

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Pubmed Data : Phytother Res. 2018 Sep ;32(9):1741-1749. Epub 2018 May 10. PMID: 29748977

Paeonol exerts anti-angiogenic and anti-metastatic activities.Jun 30, 2009

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Pubmed Data : Biol Pharm Bull. 2009 Jul ;32(7):1142-7. PMID: 19571375

Article Published Date : Jun 30, 2009

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy.Jun 15, 2022

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Pubmed Data : J Chem Neuroanat. 2022 Jun 16 ;124:102121. Epub 2022 Jun 16. PMID: 35718291

Article Published Date : Jun 15, 2022

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Epilepsy

Pharmacological Actions : Neuroprotective Agents

[+]

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Pubmed Data : Chin J Nat Med. 2023 Oct ;21(10):759-774. PMID: 37879794

Article Published Date : Sep 30, 2023

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Atherosclerosis, Inflammation

Pharmacological Actions : Gastrointestinal Agents

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Pubmed Data : Oncotarget. 2017 Apr 18 ;8(16):27093-27104. PMID: 28404919

Article Published Date : Apr 17, 2017

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Pubmed Data : Biofouling. 2021 Jul ;37(6):666-679. Epub 2021 Jul 28. PMID: 34320877

Article Published Date : Jun 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Enterobacteriaceae Infections, Klebsiella Infections

Pharmacological Actions : Anti-Bacterial Agents

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Antifungal and antibiofilm efficacy of paeonol treatment against biofilms comprising Candida albicans and Cryptococcus neoformans.Dec 31, 2021

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Pubmed Data : Front Cell Infect Microbiol. 2022 ;12:884793. Epub 2022 May 20. PMID: 35669114

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Candida Albicans, Cryptococcosis

Pharmacological Actions : Antifungal Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

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Antiproliferation and apoptosis induction of paeonol in HepG2 cells.Jan 13, 2007

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2020 Dec 31 ;66(8):33-40. Epub 2020 Dec 31. PMID: 34174974

Article Published Date : Dec 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

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Influence of paeonol on expression of COX-2 and p27 in HT-29 cells.Sep 20, 2009

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Pubmed Data : World J Gastroenterol. 2009 Sep 21 ;15(35):4410-4. PMID: 19764092

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Pubmed Data : Acta Histochem. 2013 Oct ;115(8):835-9. Epub 2013 Jun 13. PMID: 23768958

Article Published Date : Sep 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Ovarian Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

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Pubmed Data : Drug Dev Res. 2021 Jan 24. Epub 2021 Jan 24. PMID: 33491230

Article Published Date : Jan 23, 2021

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Click here to read the entire abstract

Pubmed Data : Chin J Physiol. 2023 ;66(4):248-256. PMID: 37635484

Article Published Date : Dec 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative

[+]

Paeonol suppresses lipid formation and promotes lipid degradation in adipocytes.Dec 31, 2021

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Pubmed Data : Exp Ther Med. 2022 Jan ;23(1):78. Epub 2021 Nov 25. PMID: 34938364

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Pubmed Data : Psychopharmacology (Berl). 2021 Mar 12. Epub 2021 Mar 12. PMID: 33710373

Article Published Date : Mar 11, 2021

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Cervical Cancer

Pharmacological Actions : Apoptotic

[+]

Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway.Jan 31, 2019

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Pubmed Data : Drug Des Devel Ther. 2023 ;17:2193-2208. Epub 2023 Jul 26. PMID: 37525853

Article Published Date : Dec 31, 2022

Study Type : Review

Additional Links

Substances : Paeonol

Diseases : Cardiovascular Diseases, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

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View the Evidence: 178 Abstracts with Paeonol Research

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Paeonol alleviates ulcerative colitis by modulating PPAR-γ and nuclear factor-κB activation.Aug 07, 2024

Paeonol interferes with quorum-sensing in Pseudomonas aeruginosa and modulates inflammatory responses.Dec 31, 2021

The protective effects of Paeonol on myocardial infarction rats and hypoxic H9c2 cells were achieved by up-regulating CKIP-1.May 31, 2024

Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis.Jun 28, 2020

Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells.Jul 19, 2020

Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis Aug 06, 2020

Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.Apr 30, 2017

Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis.Dec 31, 2017

Beneficial effect of paeonol on antibiotic-associated inflammatory response in mice with diarrhea.Nov 02, 2022

Cardioprotective effect of paeonol on chronic heart failure induced by doxorubicin.Dec 31, 2021

Chronic treatment with paeonol improves endothelial function in mice.Dec 31, 2016

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects.Dec 31, 2016

Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.Apr 19, 2012

Effect of paeonol on blood pressure and blood flow in artery of spontaneously hypertensive rats and its mechanisms related on vasomotion.Nov 30, 2015

Hepatoprotective effects of paeonol by suppressing hepatic stellate cell activation.May 31, 2024

Mechanism of paeonol combined with paeoniflorin against myocardial ischemia injury.Jul 31, 2021

Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats.Apr 30, 2019

Modulating effect of Paeonol in ulcerative colitis. Dec 31, 2021

Paeonol a promising botanical in protecting skin from UVB-induced photoaging.Aug 31, 2018

Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats.Aug 31, 2023

Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes.Dec 29, 2021

Paeonol administration exhibited significant antidepressant-like effects in mice with LPS-induced depression.Apr 29, 2016

Paeonol alleviated acute alcohol-induced liver injury.May 31, 2018

Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways.Jan 14, 2017

Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis.Oct 31, 2017

Paeonol alleviates placental inflammation and apoptosis in preeclampsia.Aug 23, 2022

Paeonol alleviates ulcerative colitis.Oct 31, 2023

Paeonol ameliorated ovalbumin-induced asthma through the TLR4/NF-κB and mitogen-activated protein kinase signalling.Dec 31, 2017

Paeonol ameliorated schizophrenia-like behaviors.Oct 04, 2023

Paeonol ameliorates abdominal aortic aneurysm progression by the NF-κB pathway.Aug 15, 2021

Paeonol ameliorates chronic itch and spinal astrocytic activation.Dec 31, 2020

Paeonol ameliorates cognitive deficits in streptozotocin murine model of sporadic Alzheimer's disease.Nov 18, 2021

Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF-kB pathway.Jun 08, 2022

Paeonol ameliorates glucose and lipid metabolism in experimental diabetes by activating Akt.Dec 31, 2018

Paeonol ameliorates hyperlipidemia and autophagy.Jun 23, 2024

Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-κB-mediated proinflammatory cytokine production.Oct 31, 2019

Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway.Mar 03, 2020

Paeonol ameliorates ulcerative colitis in mice by modulating the gut microbiota and metabolites.Oct 07, 2022

Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype.Jun 19, 2024

Paeonol attenuated chronic unpredictable mild stress-induced depression-like behaviours.Jun 30, 2018

Paeonol attenuated vascular fibrosis.Dec 31, 2020

Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock.Jul 31, 2018

Paeonol attenuates Cisplatin-induced nephrotoxicity in mice.Dec 31, 2012

Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling.Nov 30, 2022

Paeonol attenuates hepatic ischemia/reperfusion injury.Aug 28, 2022

Paeonol attenuates high-fat-diet-induced atherosclerosis by its anti-inflammatory activity.Dec 31, 2008

Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p.Dec 17, 2019

Paeonol attenuates nonalcoholic steatohepatitis by regulating intestinal flora.Jul 14, 2024

Paeonol can protect the endothelial cells of diabetic rats.Mar 31, 2009

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

Paeonol exerts anti-angiogenic and anti-metastatic activities.Jun 30, 2009

Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy.Jun 15, 2022

Paeonol exhibited protective effects against DMBA induced oral carcinogenesis.Dec 31, 2018

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Paeonol has significantly growth-inhibitory and apoptosis-inducing effects in gastric cancer cells both in vitro and in vivo.Sep 20, 2010

Paeonol impeded cell viability, migration and invasion and triggered apoptosis by regulating miR-21-5p/KLF6 axis in HCC cells.Dec 31, 2019

Paeonol improves angiotensin II-induced cardiac hypertrophy by suppressing ferroptosis.Aug 31, 2023

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.May 03, 2011

Paeonol increases the antioxidant and anti-inflammatory capacity of gibel carp (Carassius auratus gibelio) challenged with Aeromonas hydrophila.Mar 17, 2022

Paeonol induces protective autophagy in retinal photoreceptor cells.Dec 31, 2020

Paeonol inhibited the excretion of the inflammatory factors by P. gingivalis-induced bone marrow-derived macrophage in a dose-dependent manner.Mar 31, 2017

Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo.Sep 30, 2015

Paeonol inhibits chronic constriction injury-induced astrocytic activation and neuroinflammation.Sep 04, 2022

Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells.Jun 30, 2013

Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1.Mar 31, 2022

Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway.Jun 23, 2008

Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis.Dec 31, 2020

Paeonol may be a potent therapeutic treatment for psoriasis.Apr 30, 2017

Paeonol may be a potential therapeutic agent in the treatment of osteoarthritis.Sep 30, 2017

Paeonol may be considered as effective option for management of diabetic neuropathy.Apr 14, 2021

Paeonol pretreatment attenuates cerebral ischemic injury.Sep 30, 2014

Paeonol protects against acute pancreatitis by inhibiting M1 macrophage polarization via the NLRP3 inflammasomes pathway.Feb 07, 2022

Paeonol

View the Evidence:
178 Abstracts with Paeonol Research