Paeonol

Name	AC	CK	Focus
Arthritis	1	2
Inflammation	1	2

Name	AC	CK
Anti-Inflammatory Agents	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-6 Downregulation	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2

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Pubmed Data : Phytother Res. 2018 Sep ;32(9):1741-1749. Epub 2018 May 10. PMID: 29748977

Article Published Date : Aug 31, 2018

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Pubmed Data : Ann Vasc Surg. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34411666

Article Published Date : Aug 15, 2021

Study Type : Animal Study

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Substances : Paeonol

Diseases : Aneurysm: Aortic

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

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Paeonol ameliorates glucose and lipid metabolism in experimental diabetes by activating Akt.Dec 31, 2018

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Pubmed Data : Planta Med. 2009 Jan ;75(1):7-11. Epub 2008 Nov 10. PMID: 19003727

Article Published Date : Dec 31, 2008

Study Type : Animal Study

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Substances : Paeonol

Diseases : Atherosclerosis, C-Reactive Protein, High Fat Diet

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p.Dec 17, 2019

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Pubmed Data : Biol Pharm Bull. 2009 Jul ;32(7):1142-7. PMID: 19571375

Article Published Date : Jun 30, 2009

Study Type : Animal Study, In Vitro Study

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Substances : Paeonol

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Pubmed Data : Inflamm Res. 2017 Jul ;66(7):603-610. Epub 2017 Apr 11. PMID: 28401267

Article Published Date : Jun 30, 2017

Study Type : Animal Study

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Substances : Paeonol

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Oncotarget. 2017 Apr 18 ;8(16):27093-27104. PMID: 28404919

Article Published Date : Apr 17, 2017

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Pubmed Data : Pharmazie. 2019 02 1 ;74(2):101-106. PMID: 30782259

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Paeonol

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute

Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2020 Dec 31 ;66(8):33-40. Epub 2020 Dec 31. PMID: 34174974

Article Published Date : Dec 30, 2020

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

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Influence of paeonol on expression of COX-2 and p27 in HT-29 cells.Sep 20, 2009

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Pubmed Data : World J Gastroenterol. 2009 Sep 21 ;15(35):4410-4. PMID: 19764092

Article Published Date : Sep 20, 2009

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors

Additional Keywords : Dose Response

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Neuroprotective effects of paeonol in a cell model of Parkinson disease.Dec 31, 2014

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Pubmed Data : Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Jan ;44(1):30-6. PMID: 25851972

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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Paeonol attenuated inflammatory response of endothelial cells via stimulating monocytes-derived exosomal microRNA-223.Dec 31, 2017

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Pubmed Data : Front Pharmacol. 2018 ;9:1105. Epub 2018 Nov 20. PMID: 30515094

Paeonol reduces lipopolysaccharide-induced endothelial dysfunction and apoptosis.Dec 31, 2017

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Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:413-421. Epub 2019 Apr 25. PMID: 31030097

Article Published Date : Jun 30, 2019

Study Type : Review

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Substances : Paeonol

Diseases : Cancers: All, Cardiovascular Diseases, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Neuroprotective Agents

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Pubmed Data : PeerJ. 2021 ;9:e11278. Epub 2021 May 25. PMID: 34113484

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents

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These findings revealed that paeonol could suppress proliferation and inhibit migration and invasion in Panc-1 and Capan-1 cells.Dec 31, 2019

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View the Evidence: 115 Abstracts with Paeonol Research

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Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis.Jun 28, 2020

Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells.Jul 19, 2020

Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis Aug 06, 2020

Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.Apr 30, 2017

Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis.Dec 31, 2017

Chronic treatment with paeonol improves endothelial function in mice.Dec 31, 2016

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects.Dec 31, 2016

Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.Apr 19, 2012

Effect of paeonol on blood pressure and blood flow in artery of spontaneously hypertensive rats and its mechanisms related on vasomotion.Nov 30, 2015

Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats.Apr 30, 2019

Paeonol a promising botanical in protecting skin from UVB-induced photoaging.Aug 31, 2018

Paeonol administration exhibited significant antidepressant-like effects in mice with LPS-induced depression.Apr 29, 2016

Paeonol alleviated acute alcohol-induced liver injury.May 31, 2018

Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways.Jan 14, 2017

Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis.Oct 31, 2017

Paeonol ameliorated ovalbumin-induced asthma through the TLR4/NF-κB and mitogen-activated protein kinase signalling.Dec 31, 2017

Paeonol ameliorates abdominal aortic aneurysm progression by the NF-κB pathway.Aug 15, 2021

Paeonol ameliorates glucose and lipid metabolism in experimental diabetes by activating Akt.Dec 31, 2018

Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-κB-mediated proinflammatory cytokine production.Oct 31, 2019

Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway.Mar 03, 2020

Paeonol attenuated chronic unpredictable mild stress-induced depression-like behaviours.Jun 30, 2018

Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock.Jul 31, 2018

Paeonol attenuates Cisplatin-induced nephrotoxicity in mice.Dec 31, 2012

Paeonol attenuates high-fat-diet-induced atherosclerosis by its anti-inflammatory activity.Dec 31, 2008

Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p.Dec 17, 2019

Paeonol can protect the endothelial cells of diabetic rats.Mar 31, 2009

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

Paeonol exerts anti-angiogenic and anti-metastatic activities.Jun 30, 2009

Paeonol exhibited protective effects against DMBA induced oral carcinogenesis.Dec 31, 2018

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Paeonol has significantly growth-inhibitory and apoptosis-inducing effects in gastric cancer cells both in vitro and in vivo.Sep 20, 2010

Paeonol impeded cell viability, migration and invasion and triggered apoptosis by regulating miR-21-5p/KLF6 axis in HCC cells.Dec 31, 2019

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.May 03, 2011

Paeonol induces protective autophagy in retinal photoreceptor cells.Dec 31, 2020

Paeonol inhibited the excretion of the inflammatory factors by P. gingivalis-induced bone marrow-derived macrophage in a dose-dependent manner.Mar 31, 2017

Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo.Sep 30, 2015

Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells.Jun 30, 2013

Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway.Jun 23, 2008

Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis.Dec 31, 2020

Paeonol may be a potent therapeutic treatment for psoriasis.Apr 30, 2017

Paeonol may be a potential therapeutic agent in the treatment of osteoarthritis.Sep 30, 2017

Paeonol may be considered as effective option for management of diabetic neuropathy.Apr 14, 2021

Paeonol pretreatment attenuates cerebral ischemic injury.Sep 30, 2014

Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium.Oct 31, 2019

Paeonol protects against myocardial ischemia/reperfusion-induced injuryDec 31, 2019

Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes.Jun 30, 2017

Paeonol protects memory after ischemic stroke via inhibiting β-secretase and apoptosis.Dec 31, 2011

Paeonol represents a potential novel therapeutic approach for the treatment of pulmonary hypertension.Sep 04, 2018

Paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway.Jun 30, 2015

Paeonol reverses adriamycin induced cardiac pathological remodeling.Jul 15, 2019

Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model.Jul 31, 2019

Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase.Apr 17, 2017

Pre-treatment with paeonol might be an effective therapeutic intervention against inflammatory diseases including colitis.Jan 31, 2016

Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.Dec 31, 2016

Protection of paeonol against epirubicin-induced hepatotoxicity.Jul 21, 2019

Protective effects of paeonol on subacute/chronic brain injury during cerebral ischemia.Mar 31, 2018

The present study demonstrates paeonol has a protective ability against acetaminophen-induced hepatotoxicity.Dec 31, 2015

The protective effects of paeonol against epirubicin-induced hepatotoxicity.Jan 24, 2016

These collective results indicated that paeonol might be a promising therapeutic agent for alleviating rheumatoid arthritis progress.Aug 09, 2017

These data demonstrated that paeonol could alleviate carbon tetrachloride-induced liver fibrosis.May 31, 2019

These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of diabetic encephalopathy.Aug 08, 2013

These obtained findings evidently designate neuroprotective property of paeonol in 6-OHDA murine model of Parkinson's disease.Dec 31, 2020

These results indicated that paeonol has protective effects on endotoxin-induced kidney injury.Jun 27, 2016

These results showed that paeonol protected against periodontitis-aggravated osteoclastogenesis and alveolar bone lesion.Dec 31, 2018

These results suggest that paeonol possesses anti-aging efficacy and may have potential in treatment of neurodegenerative diseases.Feb 14, 2009

These results suggested that paeonol might have a protective potential on gingival tissue inflammation and alveolar bone loss during the process of periodontitis.Dec 31, 2013

This study provides evidence for the application of paeonol in treating acute lung injury.Dec 31, 2018

This study provides new insights into the anti-atherosclerosis activity of paeonol.Dec 31, 2016

A review of the beneficial effects exerted by paeonol in the management of atherosclerosis.Dec 31, 2017

Antibacterial and anti-biofilm activities of paeonol against Klebsiella pneumoniae and Enterobacter cloacae.Jun 30, 2021

Antiproliferation and apoptosis induction of paeonol in HepG2 cells.Jan 13, 2007

Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells.Mar 31, 2008

Paeonol

View the Evidence:
115 Abstracts with Paeonol Research