Paeonol

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2 Diseases Researched for Paeonol
NameACCKFocus
Arthritis12Locked
Inflammation12Locked
4 Pharmacological Actions Researched for Paeonol
NameACCKFocus
Anti-Inflammatory Agents12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-6 Downregulation12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked

View the Evidence:
122 Abstracts with Paeonol Research

[+]

Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis.Jun 28, 2020

Pubmed Data : Med Mycol. 2020 Jun 29. Epub 2020 Jun 29. PMID: 32598443
Article Published Date : Jun 28, 2020
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Candida Albicans, Colitis, Dysbiosis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells.Jul 19, 2020

Pubmed Data : Clin Transl Oncol. 2020 Jul 20. Epub 2020 Jul 20. PMID: 32691366
Article Published Date : Jul 19, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis Aug 06, 2020

Pubmed Data : Mol Cell Biochem. 2020 Aug 7. Epub 2020 Aug 7. PMID: 32770325
Article Published Date : Aug 06, 2020
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis
Pharmacological Actions : MicroRNA modulator
[+]

Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.Apr 30, 2017

Pubmed Data : Int Immunopharmacol. 2017 May ;46:124-132. Epub 2017 Mar 7. PMID: 28282576
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Failure: Acute
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor
[+]

Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 ;46(sup1):324-335. Epub 2018 Jan 9. PMID: 29316822
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Chronic treatment with paeonol improves endothelial function in mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(5):e0178365. Epub 2017 May 31. PMID: 28562691
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Endothelial Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Nanomedicine. 2017 ;12:6605-6616. Epub 2017 Sep 7. PMID: 28924345
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.Apr 19, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2012 Apr 20 ;17(4):4672-83. Epub 2012 Apr 20. PMID: 22522397
Article Published Date : Apr 19, 2012
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Antioxidants, Immunomodulatory
[+]

Effect of paeonol on blood pressure and blood flow in artery of spontaneously hypertensive rats and its mechanisms related on vasomotion.Nov 30, 2015

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2015 Dec ;40(24):4903-7. PMID: 27245041
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents
[+]

Mechanism of paeonol combined with paeoniflorin against myocardial ischemia injury.Jul 31, 2021

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2021 Aug ;46(15):3943-3948. PMID: 34472271
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin, Paeonol
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective
[+]

Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats.Apr 30, 2019

Pubmed Data : Hum Exp Toxicol. 2019 May ;38(5):510-518. Epub 2018 Dec 24. PMID: 30580614
Article Published Date : Apr 30, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation
Problem Substances : Indomethacin
[+]

Paeonol a promising botanical in protecting skin from UVB-induced photoaging.Aug 31, 2018

Pubmed Data : Phytother Res. 2018 Sep ;32(9):1741-1749. Epub 2018 May 10. PMID: 29748977
Article Published Date : Aug 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Photoprotective
Additional Keywords : Plant Extracts
[+]

Paeonol administration exhibited significant antidepressant-like effects in mice with LPS-induced depression.Apr 29, 2016

Pubmed Data : Psychiatry Res. 2016 Apr 30 ;238:116-121. Epub 2016 Feb 17. PMID: 27086220
Article Published Date : Apr 29, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Depression, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antidepressive Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol alleviated acute alcohol-induced liver injury.May 31, 2018

Pubmed Data : Environ Toxicol Pharmacol. 2018 Jun ;60:110-117. Epub 2018 Apr 22. PMID: 29704732
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Alcoholic Liver Disease, Chemically-Induced Liver Damage, Lipid Peroxidation
Pharmacological Actions : Heme oxygenase-1 up-regulation, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways.Jan 14, 2017

Pubmed Data : Eur J Pharmacol. 2017 Jan 15 ;795:84-93. Epub 2016 Dec 6. PMID: 27940053
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Epirubicin
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis.Oct 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Nov ;95:914-921. Epub 2017 Sep 10. PMID: 28910961
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Paeonol ameliorated ovalbumin-induced asthma through the TLR4/NF-κB and mitogen-activated protein kinase signalling.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:3063145. Epub 2018 Aug 15. PMID: 30186353
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents
[+]

Paeonol ameliorates abdominal aortic aneurysm progression by the NF-κB pathway.Aug 15, 2021

Pubmed Data : Ann Vasc Surg. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34411666
Article Published Date : Aug 15, 2021
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Aneurysm: Aortic
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
[+]

Paeonol ameliorates glucose and lipid metabolism in experimental diabetes by activating Akt.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:261. Epub 2019 Mar 19. PMID: 30941042
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-κB-mediated proinflammatory cytokine production.Oct 31, 2019

Pubmed Data : Phytother Res. 2019 Nov ;33(11):2971-2978. Epub 2019 Aug 12. PMID: 31407455
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Arthritis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway.Mar 03, 2020

Pubmed Data : J Leukoc Biol. 2020 Mar 4. Epub 2020 Mar 4. PMID: 32129526
Article Published Date : Mar 03, 2020
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation
[+]

Paeonol attenuated chronic unpredictable mild stress-induced depression-like behaviours.Jun 30, 2018

Pubmed Data : Psychopharmacology (Berl). 2018 Jul ;235(7):2177-2191. Epub 2018 May 12. PMID: 29752492
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
[+]

Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock.Jul 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Aug ;61:169-177. Epub 2018 Jun 5. PMID: 29883962
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol attenuates Cisplatin-induced nephrotoxicity in mice.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:310989. Epub 2013 Sep 19. PMID: 24171038
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Paeonol attenuates high-fat-diet-induced atherosclerosis by its anti-inflammatory activity.Dec 31, 2008

Pubmed Data : Planta Med. 2009 Jan ;75(1):7-11. Epub 2008 Nov 10. PMID: 19003727
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis, C-Reactive Protein, High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p.Dec 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Dec 18 ;9(1):19370. Epub 2019 Dec 18. PMID: 31852965
Article Published Date : Dec 17, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol can protect the endothelial cells of diabetic rats.Mar 31, 2009

Pubmed Data : Zhong Yao Cai. 2009 Apr ;32(4):564-7. PMID: 19645243
Article Published Date : Mar 31, 2009
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Diabetic Complications, Endothelial Dysfunction
Pharmacological Actions : Antioxidants
[+]

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:512. Epub 2018 May 18. PMID: 29867511
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation, SIRT1 Activator
[+]

Paeonol exerts anti-angiogenic and anti-metastatic activities.Jun 30, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2009 Jul ;32(7):1142-7. PMID: 19571375
Article Published Date : Jun 30, 2009
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cancers: All
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Paeonol exhibited protective effects against DMBA induced oral carcinogenesis.Dec 31, 2018

Pubmed Data : Biotech Histochem. 2019 Jan ;94(1):10-25. Epub 2018 Aug 13. PMID: 30101628
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Oral Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antineoplastic Agents, Antioxidants
[+]

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Pubmed Data : Mediators Inflamm. 2020 ;2020:8641026. Epub 2020 Feb 10. PMID: 32104151
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Methotrexate
[+]

Paeonol has significantly growth-inhibitory and apoptosis-inducing effects in gastric cancer cells both in vitro and in vivo.Sep 20, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2010 Sep 21 ;16(35):4483-90. PMID: 20845518
Article Published Date : Sep 20, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Paeonol impeded cell viability, migration and invasion and triggered apoptosis by regulating miR-21-5p/KLF6 axis in HCC cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Manag Res. 2020 ;12:5931-5943. Epub 2020 Jul 17. PMID: 32765094
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator
[+]

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.May 03, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Res. 2011 May 4 ;1388:141-7. Epub 2011 Mar 4. PMID: 21377451
Article Published Date : May 03, 2011
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Paeonol induces protective autophagy in retinal photoreceptor cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:667959. Epub 2021 May 26. PMID: 34122088
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Retinal Diseases
Pharmacological Actions : Antiproliferative
[+]

Paeonol inhibited the excretion of the inflammatory factors by P. gingivalis-induced bone marrow-derived macrophage in a dose-dependent manner.Mar 31, 2017

Pubmed Data : Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr 1 ;35(2):139-144. PMID: 28682542
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Porphyromonas gingivalis
Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Macrophage Colony-Stimulating Factor
[+]

Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo.Sep 30, 2015

Pubmed Data : IUBMB Life. 2015 Oct ;67(10):778-88. Epub 2015 Oct 10. PMID: 26452780
Article Published Date : Sep 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Apoptotic, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells.Jun 30, 2013

Pubmed Data : J Gastroenterol Hepatol. 2013 Jul ;28(7):1223-33. PMID: 23425217
Article Published Date : Jun 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, NF-kappaB Inhibitor
Additional Keywords : Phytotherapy
[+]

Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway.Jun 23, 2008

Pubmed Data : Eur J Pharmacol. 2008 Jun 24 ;588(1):124-33. Epub 2008 Apr 16. PMID: 18495114
Article Published Date : Jun 23, 2008
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Osteoporosis
Pharmacological Actions : NF-kappaB Inhibitor, Osteoprotective
Additional Keywords : Ovariectomy-Induced Changes
[+]

Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ASN Neuro. 2021 Jan-Dec;13:17590914211010647. PMID: 33906483
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Brain Hemorrhage: Cerebral
Pharmacological Actions : Neuroprotective Agents
[+]

Paeonol may be a potent therapeutic treatment for psoriasis.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 May ;39(5):1101-1110. Epub 2017 Mar 21. PMID: 28339016
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-23 Downregulation, MicroRNA modulator
[+]

Paeonol may be a potential therapeutic agent in the treatment of osteoarthritis.Sep 30, 2017

Pubmed Data : Inflammation. 2017 Oct ;40(5):1698-1706. PMID: 28695367
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Osteoarthritis
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Paeonol may be considered as effective option for management of diabetic neuropathy.Apr 14, 2021

Pubmed Data : Life Sci. 2021 Apr 15 ;271:119202. Epub 2021 Feb 9. PMID: 33577853
Article Published Date : Apr 14, 2021
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Diabetic Nephropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Paeonol pretreatment attenuates cerebral ischemic injury.Sep 30, 2014

Pubmed Data : Brain Res Bull. 2014 Oct ;109:61-7. Epub 2014 Oct 5. PMID: 25286445
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium.Oct 31, 2019

Pubmed Data : Biosci Biotechnol Biochem. 2019 Nov ;83(11):1992-1999. Epub 2019 Jul 31. PMID: 31362597
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Paeonol protects against myocardial ischemia/reperfusion-induced injuryDec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:586498. Epub 2021 Jan 21. PMID: 33551799
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes.Jun 30, 2017

Pubmed Data : Inflamm Res. 2017 Jul ;66(7):603-610. Epub 2017 Apr 11. PMID: 28401267
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol protects memory after ischemic stroke via inhibiting β-secretase and apoptosis.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:932823. Epub 2012 Mar 13. PMID: 22474531
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Dementia, Memory Disorders, Stroke: Ischemic
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Paeonol represents a potential novel therapeutic approach for the treatment of pulmonary hypertension.Sep 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Sep 5 ;834:257-265. Epub 2018 Jul 25. PMID: 30053410
Article Published Date : Sep 04, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Hypertension: Pulmonary, Hypoxia
Pharmacological Actions : Antihypertensive Agents
[+]

Paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jul ;12(1):1506-14. Epub 2015 Mar 11. PMID: 25760096
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Paeonol reverses adriamycin induced cardiac pathological remodeling.Jul 15, 2019

Pubmed Data : Chem Res Toxicol. 2019 Jul 16. Epub 2019 Jul 16. PMID: 31307187
Article Published Date : Jul 15, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model.Jul 31, 2019

Pubmed Data : J Cell Physiol. 2019 Aug ;234(8):14351-14363. Epub 2019 Feb 4. PMID: 30714138
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase.Apr 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Apr 18 ;8(16):27093-27104. PMID: 28404919
Article Published Date : Apr 17, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Inflammation, Ultraviolet Radiation Induced Damage
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Pre-treatment with paeonol might be an effective therapeutic intervention against inflammatory diseases including colitis.Jan 31, 2016

Pubmed Data : Inflammation. 2016 Feb ;39(1):434-446. PMID: 26433578
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Colitis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2017 ;8:193. Epub 2017 Mar 31. PMID: 28408888
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Protection of paeonol against epirubicin-induced hepatotoxicity.Jul 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Trends. 2019 Jul 22 ;13(3):253-260. Epub 2019 Jun 23. PMID: 31231109
Article Published Date : Jul 21, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Toxicity: Epirubicin, Liver Damage: Drug-Induced
Pharmacological Actions : Chemoprotective Agents, Hepatoprotective
[+]

Protective effects of paeonol on subacute/chronic brain injury during cerebral ischemia.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Apr ;15(4):3836-3846. Epub 2018 Feb 26. PMID: 29563983
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

The present study demonstrates paeonol has a protective ability against acetaminophen-induced hepatotoxicity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0154375. Epub 2016 May 4. PMID: 27144271
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

The protective effects of paeonol against epirubicin-induced hepatotoxicity.Jan 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Jan 25 ;244:1-8. Epub 2015 Dec 2. PMID: 26646421
Article Published Date : Jan 24, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Toxicity: Epirubicin
Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

These collective results indicated that paeonol might be a promising therapeutic agent for alleviating rheumatoid arthritis progress.Aug 09, 2017

Pubmed Data : Inflammopharmacology. 2017 Aug 10. Epub 2017 Aug 10. PMID: 28799079
Article Published Date : Aug 09, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

These data demonstrated that paeonol could alleviate carbon tetrachloride-induced liver fibrosis.May 31, 2019

Pubmed Data : Immunopharmacol Immunotoxicol. 2019 Jun ;41(3):438-445. Epub 2019 May 23. PMID: 31119954
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of diabetic encephalopathy.Aug 08, 2013

Pubmed Data : Neurosci Lett. 2013 Aug 9 ;549:63-8. Epub 2013 Jun 19. PMID: 23791853
Article Published Date : Aug 08, 2013
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Diabetic Complications, Encephalopathy
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

These obtained findings evidently designate neuroprotective property of paeonol in 6-OHDA murine model of Parkinson's disease.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Neurosci. 2021 Jan-Feb;12(1):43-56. Epub 2021 Jan 1. PMID: 33995926
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

These results indicated that paeonol has protective effects on endotoxin-induced kidney injury.Jun 27, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Jun 28 ;7(26):39497-39510. PMID: 27027358
Article Published Date : Jun 27, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Endotoxemia, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
[+]

These results showed that paeonol protected against periodontitis-aggravated osteoclastogenesis and alveolar bone lesion.Dec 31, 2018

Pubmed Data : Biochimie. 2019 Jan ;156:129-137. Epub 2018 Sep 10. PMID: 30213522
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggest that paeonol possesses anti-aging efficacy and may have potential in treatment of neurodegenerative diseases.Feb 14, 2009

Pubmed Data : J Neurol Sci. 2009 Feb 15 ;277(1-2):58-64. Epub 2008 Nov 12. PMID: 19007942
Article Published Date : Feb 14, 2009
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Aging: Brain , Neurodegenerative Diseases
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

These results suggested that paeonol might have a protective potential on gingival tissue inflammation and alveolar bone loss during the process of periodontitis.Dec 31, 2013

Pubmed Data : Am J Chin Med. 2014 ;42(2):361-74. PMID: 24707868
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy
[+]

This study provides evidence for the application of paeonol in treating acute lung injury.Dec 31, 2018

Pubmed Data : Pharmazie. 2019 02 1 ;74(2):101-106. PMID: 30782259
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study provides new insights into the anti-atherosclerosis activity of paeonol.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:948. Epub 2018 Jan 4. PMID: 29354055
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic, Antiproliferative , Autophagy Up-regulation
[+]

A review of the beneficial effects exerted by paeonol in the management of atherosclerosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1098617. Epub 2018 Nov 7. PMID: 30524649
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

Antibacterial and anti-biofilm activities of paeonol against Klebsiella pneumoniae and Enterobacter cloacae.Jun 30, 2021

Pubmed Data : Biofouling. 2021 Jul ;37(6):666-679. Epub 2021 Jul 28. PMID: 34320877
Article Published Date : Jun 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Enterobacteriaceae Infections, Klebsiella Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Antiproliferation and apoptosis induction of paeonol in HepG2 cells.Jan 13, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2007 Jan 14 ;13(2):250-6. PMID: 17226904
Article Published Date : Jan 13, 2007
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin
[+]

Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells.Mar 31, 2008

Pubmed Data : Anticancer Drugs. 2008 Apr ;19(4):401-9. PMID: 18454050
Article Published Date : Mar 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Antitumor and apoptosis induction effects of paeonol on mice bearing EMT6 breast carcinoma.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2014 Jul ;22(4):341-6. PMID: 25143814
Article Published Date : Jun 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Biological activities of paeonol in cardiovascular diseases.Aug 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Aug 17 ;26(16). Epub 2021 Aug 17. PMID: 34443563
Article Published Date : Aug 16, 2021
Study Type : Review
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis, Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

Cardioprotective effect of paeonol against epirubicin-induced heart injury.Apr 24, 2018

Pubmed Data : Chem Biol Interact. 2018 Apr 25 ;286:17-25. Epub 2018 Mar 2. PMID: 29505745
Article Published Date : Apr 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Toxicity: Epirubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents, MicroRNA modulator
[+]

Effect of paeonol on proliferation, apoptosis, migration, invasion and glutamine of gastric cancer cells.Dec 30, 2020

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2020 Dec 31 ;66(8):33-40. Epub 2020 Dec 31. PMID: 34174974
Article Published Date : Dec 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Influence of paeonol on expression of COX-2 and p27 in HT-29 cells.Sep 20, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2009 Sep 21 ;15(35):4410-4. PMID: 19764092
Article Published Date : Sep 20, 2009
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Dose Response
[+]

Neuroprotective effects of paeonol in a cell model of Parkinson disease.Dec 31, 2014

Pubmed Data : Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Jan ;44(1):30-6. PMID: 25851972
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Paeonol alleviates lipopolysaccharide‑induced hepatocytes injury through alteration of mitochondrial function and NF‑κB translocation.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2021 11 ;24(5). Epub 2021 Sep 9. PMID: 34498704
Article Published Date : Jan 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

Paeonol alleviates migration and invasion of endometrial stromal cells by reducing HIF-1α-regulated autophagy in endometriosis.Sep 29, 2021

Pubmed Data : Front Biosci (Landmark Ed). 2021 Sep 30 ;26(9):485-495. PMID: 34590461
Article Published Date : Sep 29, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Endometriosis
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.Dec 31, 2020

Pubmed Data : Metab Brain Dis. 2021 02 ;36(2):273-283. Epub 2020 Nov 12. PMID: 33180213
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol assists fluconazole and amphotericin B to inhibit virulence factors and pathogenicity of Candida albicans.Oct 05, 2021

Pubmed Data : Biofouling. 2021 Oct 6:1-16. Epub 2021 Oct 6. PMID: 34615415
Article Published Date : Oct 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Paeonol attenuated inflammatory response of endothelial cells via stimulating monocytes-derived exosomal microRNA-223.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1105. Epub 2018 Nov 20. PMID: 30515094
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, MicroRNA modulator
Additional Keywords : Exosomes
[+]

Paeonol attenuates advanced oxidation protein product-induced oxidative stress injury in THP-1 macrophages.Dec 31, 2013

Pubmed Data : Pharmacology. 2014 ;93(5-6):286-95. Epub 2014 Aug 21. PMID: 25170865
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol attenuates hydrogen peroxide-induced NF-κB-associated amyloid precursor protein expression.Dec 31, 2009

Pubmed Data : Am J Chin Med. 2010 ;38(6):1171-92. PMID: 21061469
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor
[+]

Paeonol attenuates inflammation by confining HMGB1 to the nucleus.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2021 Mar ;25(6):2885-2899. Epub 2021 Feb 3. PMID: 33534963
Article Published Date : Feb 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation.Jun 24, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2013 Jun 25 ;8(18):1637-43. PMID: 25206460
Article Published Date : Jun 24, 2013
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Brain: Microglial Activation, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Paeonol attenuates quorum-sensing regulated virulence and biofilm formation in Pseudomonas aeruginosa.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2021 ;12:692474. Epub 2021 Aug 4. PMID: 34421847
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents, Quorum Sensing Inhibition
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Paeonol could be a promising treatment of hepatocellular carcinoma.Apr 27, 2008

Pubmed Data : Eur J Pharmacol. 2008 Apr 28 ;584(2-3):246-52. Epub 2008 Feb 15. PMID: 18329639
Article Published Date : Apr 27, 2008
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol could inhibit IL-1beta and TNF-alpha expression to protect vascular endothelial cells from being injured by lipopolysaccharide.Feb 28, 2014

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2014 Mar ;39(6):1058-63. PMID: 24956851
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Oct ;14(4):3213-3220. Epub 2017 Aug 3. PMID: 28912871
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Ovarian Cancer
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Radiosensitizer, Vascular Endothelial Growth Factor Inhibitors
[+]

Paeonol exerts anti‑tumor activity against colorectal cancer cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2020 Aug ;46(2):675-684. Epub 2020 Jun 4. PMID: 32626954
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):7513-7519. Epub 2017 Sep 21. PMID: 28944890
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Paeonol for the treatment of atherosclerotic cardiovascular disease.Dec 31, 2020

Pubmed Data : Front Cardiovasc Med. 2021 ;8:690116. Epub 2021 Jul 21. PMID: 34368250
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Substances : Paeonol
Diseases : Cardiovascular Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

paeonol has the potential therapeutic development for use in anti-inflammatory and vascular disorders.Oct 31, 2009

Pubmed Data : Phytomedicine. 2009 Nov ;16(11):1027-32. Epub 2009 Jun 21. PMID: 19541467
Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin, Paeonol
Diseases : Atherosclerosis, Cardiovascular Diseases
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords : Plant Extracts
[+]

Paeonol induces apoptosis in human ovarian cancer cells.Sep 30, 2013

Pubmed Data : Acta Histochem. 2013 Oct ;115(8):835-9. Epub 2013 Jun 13. PMID: 23768958
Article Published Date : Sep 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2018 Sep ;42(3):1473-1483. Epub 2018 May 23. PMID: 29845222
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR-126-5p/ZEB2 axis.Oct 11, 2021

Pubmed Data : Drug Dev Res. 2021 Oct 12. Epub 2021 Oct 12. PMID: 34636432
Article Published Date : Oct 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, MicroRNA modulator
[+]

Paeonol may be one of promising candidate for the treatment of atherosclerosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:95. Epub 2018 Feb 8. PMID: 29472864
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Autophagy Inhibitors, MicroRNA modulator
[+]

Paeonol prevents migration and invasion, and promotes apoptosis of cervical cancer cells.May 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2021 Jun ;23(6). Epub 2021 Mar 31. PMID: 33786614
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cervical Cancer
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-metastatic, Antiproliferative , Apoptotic
[+]

Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy.Aug 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2021 Aug 10 ;46:102098. Epub 2021 Aug 10. PMID: 34418601
Article Published Date : Aug 09, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cardiomyopathy
Pharmacological Actions : Antioxidants, Cardioprotective, STAT3 Activation
[+]

Paeonol protects melanocytes against hydrogen peroxide-induced oxidative stress.Jan 23, 2021

Pubmed Data : Drug Dev Res. 2021 Jan 24. Epub 2021 Jan 24. PMID: 33491230
Article Published Date : Jan 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Paeonol protects mitochondrial injury and prevents pulmonary vascular remodeling in hypoxia.Sep 30, 2019

Pubmed Data : Respir Physiol Neurobiol. 2019 Oct ;268:103252. Epub 2019 Jul 10. PMID: 31301382
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Hypoxia
Pharmacological Actions : Cardioprotective
[+]

Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury.Mar 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2014 Apr ;35(4):483-8. Epub 2014 Feb 24. PMID: 24562307
Article Published Date : Mar 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Atherosclerosis, Cholesterol: Oxidation
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol reduces lipopolysaccharide-induced endothelial dysfunction and apoptosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2018 03 ;364(3):420-432. Epub 2017 Dec 19. PMID: 29259041
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Endothelial Dysfunction, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic
[+]

Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock.May 31, 2014

Pubmed Data : Fundam Clin Pharmacol. 2014 Jun ;28(3):268-76. Epub 2013 Feb 17. PMID: 23413967
Article Published Date : May 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol suppresses neuroinflammatory responses in LPS-activated microglia cells.Nov 30, 2016

Pubmed Data : Inflammation. 2016 Dec ;39(6):1904-1917. PMID: 27624059
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation
[+]

Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis.Mar 26, 2013

Pubmed Data : J Ethnopharmacol. 2013 Mar 27 ;146(2):543-51. Epub 2013 Jan 26. PMID: 23357312
Article Published Date : Mar 26, 2013
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cholesterol: Oxidation, Lipid Peroxidation
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor
[+]

Paeonol suppresses proliferation and motility of non-small-cell lung cancer cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:572616. Epub 2020 Nov 12. PMID: 33442382
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, STAT3 Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol triggers apoptosis in HeLa cervical cancer cells: the role of mitochondria-related caspase pathway.Mar 11, 2021

Pubmed Data : Psychopharmacology (Berl). 2021 Mar 12. Epub 2021 Mar 12. PMID: 33710373
Article Published Date : Mar 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic
[+]

Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2019 Feb ;17(2):1761-1767. Epub 2018 Nov 19. PMID: 30675235
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic
[+]

Paeonol: pharmacological effects and mechanisms of action.Jun 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:413-421. Epub 2019 Apr 25. PMID: 31030097
Article Published Date : Jun 30, 2019
Study Type : Review
Additional Links
Substances : Paeonol
Diseases : Cancers: All, Cardiovascular Diseases, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Neuroprotective Agents
[+]

Role of paeonol in an astrocyte model of Parkinson's disease.Oct 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2017 Oct 3 ;23:4740-4748. Epub 2017 Oct 3. PMID: 28972959
Article Published Date : Oct 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis.Apr 06, 2021

Pubmed Data : Pharmacol Res. 2021 Apr 7:105599. Epub 2021 Apr 7. PMID: 33838291
Article Published Date : Apr 06, 2021
Study Type : Review
Additional Links
Substances : Allicin, Apigenin, Blueberry, Capsaicin, Celastrol, EGCG (Epigallocatechin gallate), Ellagic Acid, Folic Acid , Ginsenosides, Kaempferol, Lycopene, Paeoniflorin, Paeonol, Quercetin, Resveratrol
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines.May 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2007 Jun ;28(6):869-78. PMID: 17506946
Article Published Date : May 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Synergistic effect of paeonol and cisplatin on oesophageal cancer cell lines.Jun 30, 2008

Pubmed Data : Dig Liver Dis. 2008 Jul ;40(7):531-9. Epub 2008 Mar 12. PMID: 18339596
Article Published Date : Jun 30, 2008
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

The effects of total glucosides of paeony and paeoniflorin on inflammatory-immune responses in rheumatoid arthritis.Dec 31, 2018

Pubmed Data : Funct Plant Biol. 2019 Jan ;46(2):107-117. PMID: 32172753
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Paeoniflorin, Paeonol
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

The paeonol target gene autophagy-related 5 has a potential therapeutic value in psoriasis treatment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2021 ;9:e11278. Epub 2021 May 25. PMID: 34113484
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

These findings revealed that paeonol could suppress proliferation and inhibit migration and invasion in Panc-1 and Capan-1 cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Manag Res. 2020 ;12:641-651. Epub 2020 Jan 29. PMID: 32099461
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Transforming growth factor beta (TGF-β) inhibitor
[+]

These findings suggest that combination of paeonol and epirubicin is potentially applicable for breast cancer treatment.Aug 31, 2016

Pubmed Data : Tumour Biol. 2016 Sep ;37(9):12301-12313. Epub 2016 Jun 7. PMID: 27272157
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cardioprotective, Chemoprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

These results indicate that paeonol may has the potential to improve learning and memory in Alzheimer's disease.May 14, 2018

Pubmed Data : Eur J Pharmacol. 2018 May 15 ;827:227-237. Epub 2018 Mar 15. PMID: 29550337
Article Published Date : May 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents

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