Paeonol

Name	AC	CK	Focus
Arthritis	1	2
Inflammation	1	2

Name	AC	CK
Anti-Inflammatory Agents	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-6 Downregulation	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2

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Pubmed Data : Front Nutr. 2022 ;9:846684. Epub 2022 Apr 13. PMID: 35495936

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Paeonol

Diseases : Ulcerative Colitis

Pharmacological Actions : Gastrointestinal Agents, Gastroprotective, Transforming growth factor beta (TGF-β) inhibitor

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Paeonol a promising botanical in protecting skin from UVB-induced photoaging.Aug 31, 2018

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Pubmed Data : Phytother Res. 2018 Sep ;32(9):1741-1749. Epub 2018 May 10. PMID: 29748977

Article Published Date : Aug 31, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Paeonol

Diseases : Aging Skin, Ultraviolet Radiation Induced Damage

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Photoprotective

Additional Keywords : Plant Extracts

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Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes.Dec 29, 2021

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Pubmed Data : Ann Vasc Surg. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34411666

Article Published Date : Aug 15, 2021

Study Type : Animal Study

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Substances : Paeonol

Diseases : Aneurysm: Aortic

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

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Paeonol ameliorates chronic itch and spinal astrocytic activation.Dec 31, 2020

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Pubmed Data : J Chem Neuroanat. 2022 Jun 16 ;124:102121. Epub 2022 Jun 16. PMID: 35718291

Article Published Date : Jun 15, 2022

Study Type : Animal Study

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Substances : Paeonol

Diseases : Epilepsy

Pharmacological Actions : Neuroprotective Agents

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Pubmed Data : Oncotarget. 2017 Apr 18 ;8(16):27093-27104. PMID: 28404919

Article Published Date : Apr 17, 2017

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Pubmed Data : Biofouling. 2021 Jul ;37(6):666-679. Epub 2021 Jul 28. PMID: 34320877

Article Published Date : Jun 30, 2021

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Enterobacteriaceae Infections, Klebsiella Infections

Pharmacological Actions : Anti-Bacterial Agents

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Antifungal and antibiofilm efficacy of paeonol treatment against biofilms comprising Candida albicans and Cryptococcus neoformans.Dec 31, 2021

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Pubmed Data : Front Cell Infect Microbiol. 2022 ;12:884793. Epub 2022 May 20. PMID: 35669114

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Candida Albicans, Cryptococcosis

Pharmacological Actions : Antifungal Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

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Antiproliferation and apoptosis induction of paeonol in HepG2 cells.Jan 13, 2007

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2020 Dec 31 ;66(8):33-40. Epub 2020 Dec 31. PMID: 34174974

Article Published Date : Dec 30, 2020

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

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Influence of paeonol on expression of COX-2 and p27 in HT-29 cells.Sep 20, 2009

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Pubmed Data : World J Gastroenterol. 2009 Sep 21 ;15(35):4410-4. PMID: 19764092

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Pubmed Data : Front Pharmacol. 2018 ;9:1105. Epub 2018 Nov 20. PMID: 30515094

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Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):7513-7519. Epub 2017 Sep 21. PMID: 28944890

Article Published Date : Oct 31, 2017

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Paeonol exhibits neuroprotective activity via a carrier-mediated transport system.Jul 17, 2022

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Pubmed Data : Acta Histochem. 2013 Oct ;115(8):835-9. Epub 2013 Jun 13. PMID: 23768958

Article Published Date : Sep 30, 2013

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Ovarian Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

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Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line.Aug 31, 2018

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Pubmed Data : Mol Med Rep. 2021 Jun ;23(6). Epub 2021 Mar 31. PMID: 33786614

Article Published Date : May 31, 2021

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Cervical Cancer

Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-metastatic, Antiproliferative , Apoptotic

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Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy.Aug 09, 2021

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Pubmed Data : Psychopharmacology (Berl). 2021 Mar 12. Epub 2021 Mar 12. PMID: 33710373

Article Published Date : Mar 11, 2021

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Cervical Cancer

Pharmacological Actions : Apoptotic

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Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway.Jan 31, 2019

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Pubmed Data : Oncol Lett. 2019 Feb ;17(2):1761-1767. Epub 2018 Nov 19. PMID: 30675235

Article Published Date : Jan 31, 2019

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic

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Paeonol: pharmacological effects and mechanisms of action.Jun 30, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:413-421. Epub 2019 Apr 25. PMID: 31030097

Article Published Date : Jun 30, 2019

Study Type : Review

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Substances : Paeonol

Diseases : Cancers: All, Cardiovascular Diseases, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Neuroprotective Agents

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Pubmed Data : PeerJ. 2021 ;9:e11278. Epub 2021 May 25. PMID: 34113484

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Paeonol

Diseases : Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents

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These findings revealed that paeonol could suppress proliferation and inhibit migration and invasion in Panc-1 and Capan-1 cells.Dec 31, 2019

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View the Evidence: 148 Abstracts with Paeonol Research

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Paeonol interferes with quorum-sensing in Pseudomonas aeruginosa and modulates inflammatory responses.Dec 31, 2021

Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis.Jun 28, 2020

Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells.Jul 19, 2020

Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis Aug 06, 2020

Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.Apr 30, 2017

Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis.Dec 31, 2017

Cardioprotective effect of paeonol on chronic heart failure induced by doxorubicin.Dec 31, 2021

Chronic treatment with paeonol improves endothelial function in mice.Dec 31, 2016

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects.Dec 31, 2016

Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.Apr 19, 2012

Effect of paeonol on blood pressure and blood flow in artery of spontaneously hypertensive rats and its mechanisms related on vasomotion.Nov 30, 2015

Mechanism of paeonol combined with paeoniflorin against myocardial ischemia injury.Jul 31, 2021

Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats.Apr 30, 2019

Modulating effect of Paeonol in ulcerative colitis. Dec 31, 2021

Paeonol a promising botanical in protecting skin from UVB-induced photoaging.Aug 31, 2018

Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes.Dec 29, 2021

Paeonol administration exhibited significant antidepressant-like effects in mice with LPS-induced depression.Apr 29, 2016

Paeonol alleviated acute alcohol-induced liver injury.May 31, 2018

Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways.Jan 14, 2017

Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis.Oct 31, 2017

Paeonol ameliorated ovalbumin-induced asthma through the TLR4/NF-κB and mitogen-activated protein kinase signalling.Dec 31, 2017

Paeonol ameliorates abdominal aortic aneurysm progression by the NF-κB pathway.Aug 15, 2021

Paeonol ameliorates chronic itch and spinal astrocytic activation.Dec 31, 2020

Paeonol ameliorates cognitive deficits in streptozotocin murine model of sporadic Alzheimer's disease.Nov 18, 2021

Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF-kB pathway.Jun 08, 2022

Paeonol ameliorates glucose and lipid metabolism in experimental diabetes by activating Akt.Dec 31, 2018

Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-κB-mediated proinflammatory cytokine production.Oct 31, 2019

Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway.Mar 03, 2020

Paeonol attenuated chronic unpredictable mild stress-induced depression-like behaviours.Jun 30, 2018

Paeonol attenuated vascular fibrosis.Dec 31, 2020

Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock.Jul 31, 2018

Paeonol attenuates Cisplatin-induced nephrotoxicity in mice.Dec 31, 2012

Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling.Nov 30, 2022

Paeonol attenuates high-fat-diet-induced atherosclerosis by its anti-inflammatory activity.Dec 31, 2008

Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p.Dec 17, 2019

Paeonol can protect the endothelial cells of diabetic rats.Mar 31, 2009

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

Paeonol exerts anti-angiogenic and anti-metastatic activities.Jun 30, 2009

Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy.Jun 15, 2022

Paeonol exhibited protective effects against DMBA induced oral carcinogenesis.Dec 31, 2018

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Paeonol has significantly growth-inhibitory and apoptosis-inducing effects in gastric cancer cells both in vitro and in vivo.Sep 20, 2010

Paeonol impeded cell viability, migration and invasion and triggered apoptosis by regulating miR-21-5p/KLF6 axis in HCC cells.Dec 31, 2019

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.May 03, 2011

Paeonol increases the antioxidant and anti-inflammatory capacity of gibel carp (Carassius auratus gibelio) challenged with Aeromonas hydrophila.Mar 17, 2022

Paeonol induces protective autophagy in retinal photoreceptor cells.Dec 31, 2020

Paeonol inhibited the excretion of the inflammatory factors by P. gingivalis-induced bone marrow-derived macrophage in a dose-dependent manner.Mar 31, 2017

Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo.Sep 30, 2015

Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells.Jun 30, 2013

Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1.Mar 31, 2022

Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway.Jun 23, 2008

Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis.Dec 31, 2020

Paeonol may be a potent therapeutic treatment for psoriasis.Apr 30, 2017

Paeonol may be a potential therapeutic agent in the treatment of osteoarthritis.Sep 30, 2017

Paeonol may be considered as effective option for management of diabetic neuropathy.Apr 14, 2021

Paeonol pretreatment attenuates cerebral ischemic injury.Sep 30, 2014

Paeonol protects against acute pancreatitis by inhibiting M1 macrophage polarization via the NLRP3 inflammasomes pathway.Feb 07, 2022

Paeonol protects against doxorubicin-induced cardiotoxicity.Jul 13, 2022

Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium.Oct 31, 2019

Paeonol protects against methotrexate-induced nephrotoxicity.Dec 31, 2021

Paeonol protects against myocardial ischemia/reperfusion-induced injuryDec 31, 2019

Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes.Jun 30, 2017

Paeonol protects memory after ischemic stroke via inhibiting β-secretase and apoptosis.Dec 31, 2011

Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury.Mar 17, 2022

Paeonol represents a potential novel therapeutic approach for the treatment of pulmonary hypertension.Sep 04, 2018

Paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway.Jun 30, 2015

Paeonol reverses adriamycin induced cardiac pathological remodeling.Jul 15, 2019

Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model.Jul 31, 2019

Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase.Apr 17, 2017

Pre-treatment with paeonol might be an effective therapeutic intervention against inflammatory diseases including colitis.Jan 31, 2016

Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.Dec 31, 2016

Protection of paeonol against epirubicin-induced hepatotoxicity.Jul 21, 2019

Paeonol

View the Evidence:
148 Abstracts with Paeonol Research