Palmitoylethanolamide

Name	AC	CK	Focus
Cocaine Addiction	1	2
Cocaine Withdrawal	1	2

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Therapeutic effect of palmitoylethanolamide in cognitive decline.Dec 31, 2021

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Pubmed Data : Front Psychiatry. 2022 ;13:1038122. Epub 2022 Oct 28. PMID: 36387000

Article Published Date : Dec 31, 2021

Study Type : Meta Analysis, Review

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Substances : Palmitoylethanolamide

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

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Palmitoylethanolamide may be a useful treatment for pain and is generally well tolerated in research populations.Jun 30, 2017

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Effectiveness of palmitoylethanolamide on endothelial dysfunction in ocular hypertensive patients.Jan 31, 2013

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Pubmed Data : Invest Ophthalmol Vis Sci. 2013 Feb 1 ;54(2):968-73. Epub 2013 Feb 1. PMID: 23307959

Article Published Date : Jan 31, 2013

Study Type : Human Study

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Substances : Palmitoylethanolamide

Diseases : Endothelial Dysfunction

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Effects of ultramicronized palmitoylethanolamide in COVID-19 early stages.Feb 18, 2022

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Pubmed Data : Pharmaceuticals (Basel). 2022 Feb 19 ;15(2). Epub 2022 Feb 19. PMID: 35215365

Article Published Date : Feb 18, 2022

Study Type : Human Study

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Substances : Palmitoylethanolamide

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

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Micronized palmitoylethanolamide-polydatin reduces the painful symptomatology in patients with interstitial cystitis/bladder pain syndrome.Dec 31, 2018

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Pubmed Data : Biomed Res Int. 2019 ;2019:9828397. Epub 2019 Nov 11. PMID: 31828153

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Palmitoylethanolamide may be an innovative therapeutic intervention as add-on therapy to tapentadol for the management of chronic low back pain.Dec 18, 2017

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Pubmed Data : Med Sci (Basel). 2022 Jul 14 ;10(3). Epub 2022 Jul 14. PMID: 35893119

Article Published Date : Jul 13, 2022

Study Type : Human Study

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Substances : Palmitoylethanolamide

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory

Additional Keywords : Cytokine Storm, Long Covid

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These data suggest that palmitoylethanolamide is effective in treating temporomandibular joint inflammatory pain.Dec 31, 2011

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Pubmed Data : J Orofac Pain. 2012 ;26(2):99-104. PMID: 22558609

Article Published Date : Dec 31, 2011

Study Type : Human Study

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Substances : Palmitoylethanolamide

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Ibuprofen

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Ultra-micronized palmitoylethanolamide effects on sleep-wake rhythm and neuropathic pain phenotypes in patients with carpal tunnel syndrome.Dec 31, 2017

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Pubmed Data : CNS Neurol Disord Drug Targets. 2018 ;17(4):291-298. PMID: 29676237

Article Published Date : Dec 31, 2017

Study Type : Human Study

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Substances : Palmitoylethanolamide

Diseases : Carpal Tunnel Syndrome, Chronic Pain, Neuropathic Pain, Sleep Disorders

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Ultra-micronized palmitoylethanolamide slowed down disease progression and disability in Parkinson's disease patients.Dec 31, 2016

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Pubmed Data : Dermatitis. 2021 Mar 4. Epub 2021 Mar 4. PMID: 33654018

Article Published Date : Mar 03, 2021

Study Type : Animal Study

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Substances : Cannabidiol, Palmitoylethanolamide

Diseases : Dermatitis

Pharmacological Actions : Anti-Inflammatory Agents

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Chronic oral palmitoylethanolamide administration rescues cognitive deficit. Feb 04, 2020

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Pubmed Data : J Clin Med. 2020 Feb 5 ;9(2). Epub 2020 Feb 5. PMID: 32033363

Article Published Date : Feb 04, 2020

Study Type : Transgenic Animal Study

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Substances : Palmitoylethanolamide

Diseases : Alzheimer's Disease, Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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Co-ultramicronized palmitoylethanolamide and luteolin promotes neuronal regeneration after spinal cord injury.Dec 31, 2015

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Pubmed Data : Front Neurosci. 2018 ;12:145. Epub 2018 Mar 28. PMID: 29662433

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Palmitoylethanolamide

Diseases : Asphyxia

Pharmacological Actions : Neuroprotective Agents

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Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain.Dec 31, 2020

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Pubmed Data : Pharmacol Res. 2021 05 ;167:105545. Epub 2021 Mar 12. PMID: 33722712

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Pubmed Data : Front Pharmacol. 2016 ;7:382. Epub 2016 Oct 14. PMID: 27790149

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Palmitoylethanolamide

Diseases : Endometriosis

Pharmacological Actions : Angiogenesis Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Additional Keywords : Gut-brain Axis

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Pubmed Data : Front Pharmacol. 2018 ;9:709. Epub 2018 Jul 13. PMID: 30057547

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Palmitoylethanolamide

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

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Palmitoylethanolamide may improve inflammation-driven angiogenesis in colonic mucosa.Dec 31, 2015

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Pubmed Data : J Pharmacol Exp Ther. 2016 Nov ;359(2):310-318. Epub 2016 Sep 8. PMID: 27608657

Article Published Date : Oct 31, 2016

Study Type : Animal Study

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Substances : Palmitoylethanolamide

Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy, Hyperalgesia

Pharmacological Actions : Chemoprotective Agents

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Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats.Mar 31, 2014

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Pubmed Data : Endocrinology. 2014 Apr ;155(4):1291-301. Epub 2014 Jan 15. PMID: 24428531

Article Published Date : Mar 31, 2014

Study Type : Animal Study

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Substances : Palmitoylethanolamide

Diseases : Alcohol Toxicity , Obesity

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Ovariectomy-Induced Changes

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Palmitoylethanolamide prevents Parkinsonian phenotypes in aged mice.Mar 18, 2018

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Pubmed Data : Mol Neurobiol. 2018 Mar 19. Epub 2018 Mar 19. PMID: 29552727

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Pubmed Data : CNS Neurol Disord Drug Targets. 2015 ;14(10):1350-65. PMID: 26295827

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

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Substances : Luteolin, Palmitoylethanolamide

Diseases : Brain Inflammation , Parkinson's Disease

Pharmacological Actions : anti-inflammatory, Autophagy Up-regulation, Neuroprotective Agents

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These findings provide novel proofs on the effects of um-palmitoylethanolamide in colon carcinogenesis.Apr 15, 2021

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Pubmed Data : Transl Psychiatry. 2018 Jan 31 ;8(1):32. Epub 2018 Jan 31. PMID: 29382825

Article Published Date : Jan 30, 2018

Study Type : Transgenic Animal Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents

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A review of palmitoylethanolamide in central nervous system health and disease.Jul 31, 2014

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Pubmed Data : Pharmacol Res. 2014 Aug ;86:32-41. Epub 2014 May 17. PMID: 24844438

Article Published Date : Jul 31, 2014

Study Type : Review

Additional Links

Substances : Palmitoylethanolamide

Diseases : Inflammation, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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An update of palmitoylethanolamide and luteolin effects in preclinical and clinical studies of neuroinflammatory events.Mar 04, 2020

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Pubmed Data : J Pain Res. 2015 ;8:729-34. Epub 2015 Oct 23. PMID: 26604814

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Palmitoylethanolamide

Diseases : Carpal Tunnel Syndrome, Nerve Compression Syndromes

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

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Palmitoylethanolamide-either by decreasing its degradation or exogenous administration-is able to keep neuroinflammation within its physiological limits.Dec 14, 2020

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Pubmed Data : Int J Mol Sci. 2020 Dec 15 ;21(24). Epub 2020 Dec 15. PMID: 33333772

Article Published Date : Dec 14, 2020

Study Type : Review

Additional Links

Substances : Palmitoylethanolamide

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

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Click here to read the entire abstract

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Pubmed Data : CNS Neurol Disord Drug Targets. 2013 Feb 1 ;12(1):62-9. PMID: 23394526

Article Published Date : Jan 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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View the Evidence: 139 Abstracts with Palmitoylethanolamide Research

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Therapeutic effect of palmitoylethanolamide in cognitive decline.Dec 31, 2021

Palmitoylethanolamide may be a useful treatment for pain and is generally well tolerated in research populations.Jun 30, 2017

Palmitoylethanolamide might represent an exciting, new therapeutic strategy to manage chronic and neuropathic pain associated with neuroinflammation.Jan 31, 2016

A phase-2 pilot study of a therapeutic combination of Δ 9-tetrahydracannabinol and palmitoylethanolamide for adults with Tourette's syndrome.Aug 02, 2021

Adjuvant palmitoylethanolamide therapy with risperidone improves negative symptoms in patients with schizophrenia.Sep 30, 2022

Combination of rehabilitative therapy with ultramicronized palmitoylethanolamide for chronic low back pain.May 31, 2020

Dietary supplement palmithoylethanolamide/polydatin could a promising natural approach for pain management in irritable bowel syndrome.Dec 31, 2016

Effect of palmitoylethanolamide on inner retinal function in glaucoma.Jan 25, 2020

Effect of ultra-micronized palmitoylethanolamide and luteolin on olfaction and memory in patients with long covid.Aug 16, 2022

Effectiveness of palmitoylethanolamide on endothelial dysfunction in ocular hypertensive patients.Jan 31, 2013

Effects of ultramicronized palmitoylethanolamide in COVID-19 early stages.Feb 18, 2022

Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania.Sep 30, 2022

Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients.Oct 24, 2018

Micronized palmitoylethanolamide reduces the symptoms of neuropathic pain in diabetic patients.Dec 31, 2013

Micronized palmitoylethanolamide, hempseed oil, and maritime pine bark dry extract for pelvic pain.Feb 13, 2023

Micronized palmitoylethanolamide-polydatin reduces the painful symptomatology in patients with interstitial cystitis/bladder pain syndrome.Dec 31, 2018

Olfactory rehabilitation and Palmitoylethanolamide +Luteolin oral supplement might prevent SARS-CoV-2 associated olfactory impairment.Dec 31, 2020

Palmitoylethanolamide adjunctive therapy to citalopram can effectively improve symptoms of patients with major depressive disorder.Feb 20, 2018

Palmitoylethanolamide and Alpha-lipoic acid are beneficial in treating patients with chronic prostatitis/chronic pelvic pain syndrome.Mar 30, 2017

Palmitoylethanolamide and cannabidiol prevent inflammation-induced hyperpermeability of the human gut.Jan 03, 2019

Palmitoylethanolamide as adjunctive therapy for autism.Jul 31, 2018

Palmitoylethanolamide could be a potentially effective nutraceutical to treat long-COVID.Dec 31, 2021

Palmitoylethanolamide may be an innovative therapeutic intervention as add-on therapy to tapentadol for the management of chronic low back pain.Dec 18, 2017

Palmitoylethanolamide nutraceuticals could be useful in migraine prevention.Jun 30, 2022

Palmitoylethanolamide reduces intraocular pressure and improves visual field indices in individuals affected by normal-tension glaucoma.Aug 31, 2014

Palmitoylethanolamide reduces proinflammatory markers in unvaccinated adults recently diagnosed with COVID-19.Oct 05, 2022

Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy.Nov 30, 2011

Research suggests the efficacy and safety of palmitoylethanolamide in the treatment of pain associated with fibromyalgia.Nov 30, 2015

The effect of palmitoylethanolamide on pain intensity, central and peripheral sensitization, and pain modulation in healthy volunteers.Sep 30, 2022

The use of palmitoylethanolamide in the treatment of long COVID.Jul 13, 2022

These data suggest that palmitoylethanolamide is effective in treating temporomandibular joint inflammatory pain.Dec 31, 2011

Ultra-micronized palmitoylethanolamide effects on sleep-wake rhythm and neuropathic pain phenotypes in patients with carpal tunnel syndrome.Dec 31, 2017

Ultra-micronized palmitoylethanolamide slowed down disease progression and disability in Parkinson's disease patients.Dec 31, 2016

Palmitoylethanolamide ameliorates neuroinflammation.Jun 10, 2022

Palmitoylethanolamide and luteolin in combination could have beneficial effects in autism.Dec 31, 2016

Palmitoylethanolamide demonstrated effective pain relief within 48 hours at an administered daily dose of 900 mg.Jul 20, 2021

Palmitoylethanolamide mitigates paclitaxel toxicity in primary dorsal root ganglion neurons.Dec 13, 2022

Palmitoylethanolamide treatment led to an improved clinical picture.Oct 31, 2012

A formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models.Aug 01, 2017

A palmitoylethanolamide producing Lactobacillus paracasei improves Clostridium difficile toxin A-induced colitis.Dec 31, 2020

Administration of palmitoylethanolamide protects the neurovascular unit and reduces secondary injury after traumatic brain injury.Oct 31, 2012

Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate.Aug 31, 2021

Cannabinoid formulations have therapeutic promise for dermatitis. Mar 03, 2021

Chronic oral palmitoylethanolamide administration rescues cognitive deficit. Feb 04, 2020

Co-ultramicronized palmitoylethanolamide and luteolin promotes neuronal regeneration after spinal cord injury.Dec 31, 2015

Delay of morphine tolerance by palmitoylethanolamide.Dec 31, 2014

Effect of ultra-Micronized-palmitoylethanolamide and acetyl-l-carnitine on experimental model of inflammatory pain.Feb 16, 2021

Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice.May 31, 2012

Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain function.Dec 31, 2018

Management of acute lung injury: palmitoylethanolamide as a new approach.May 23, 2021

Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models.Dec 31, 2013

Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease.Dec 31, 2011

Palmitoylethanolamide ameliorates hippocampal damage and behavioural dysfunction after perinatal asphyxia.Dec 31, 2017

Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain.Dec 31, 2020

Palmitoylethanolamide and luteolin compounds exerts a significant antidepressant effect a low doses.Oct 31, 2013

Palmitoylethanolamide and luteolin may be beneficial in demyelinating disorders such as multiple sclerosis.Aug 17, 2017

Palmitoylethanolamide and polydatin are capable of decreasing inflammatory bowel disease.Mar 15, 2021

Palmitoylethanolamide and polydatin treatment causes endometriotic lesion regression.Dec 31, 2015

Palmitoylethanolamide and silymarin treatment attenuated the degree of renal inflammation.Sep 04, 2015

Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference.Jan 10, 2018

Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.Oct 31, 2015

Palmitoylethanolamide attenuates the degree of inflammation while preserving the blood-retinal barrier in rats with experimental diabetic retinopathy.Dec 14, 2015

Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer's disease.Sep 10, 2014

Palmitoylethanolamide could be effective in type 1-diabetic patients not only as pain reliever but also in controlling the development of pathology.Dec 31, 2014

Palmitoylethanolamide could represent a novel approach for monitoring pain during trigeminal nerve sensitization.Sep 30, 2018

Palmitoylethanolamide counteracts autistic-like behaviours in animalsOct 31, 2018

Palmitoylethanolamide counteracts enteric inflammation and bowel motor dysfunctions in a mouse model of Alzheimer's disease.Dec 31, 2020

Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet-induced obese mice.Dec 31, 2019

Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice.Apr 30, 2022

Palmitoylethanolamide improves colon inflammation.Jul 31, 2014

Palmitoylethanolamide improves murine experimental colitis.Dec 31, 2014

Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous inflammation.Feb 14, 2014

Palmitoylethanolamide

View the Evidence:
139 Abstracts with Palmitoylethanolamide Research