Palmitoylethanolamide

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2 Diseases Researched for Palmitoylethanolamide
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Cocaine Addiction12Locked
Cocaine Withdrawal12Locked

View the Evidence:
85 Abstracts with Palmitoylethanolamide Research

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Palmitoylethanolamide may be a useful treatment for pain and is generally well tolerated in research populations.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Physician. 2017 Jul ;20(5):353-362. PMID: 28727699
Article Published Date : Jun 30, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Palmitoylethanolamide might represent an exciting, new therapeutic strategy to manage chronic and neuropathic pain associated with neuroinflammation.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Physician. 2016 Feb ;19(2):11-24. PMID: 26815246
Article Published Date : Jan 31, 2016
Study Type : Meta Analysis
Additional Links
Substances : Palmitoylethanolamide
Diseases : Inflammation, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Dietary supplement palmithoylethanolamide/polydatin could a promising natural approach for pain management in irritable bowel syndrome.Dec 31, 2016

Pubmed Data : Aliment Pharmacol Ther. 2017 04 ;45(7):909-922. Epub 2017 Feb 6. PMID: 28164346
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Irritable Bowel Syndrome
Pharmacological Actions : Analgesics
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Effectiveness of palmitoylethanolamide on endothelial dysfunction in ocular hypertensive patients.Jan 31, 2013

Pubmed Data : Invest Ophthalmol Vis Sci. 2013 Feb 1 ;54(2):968-73. Epub 2013 Feb 1. PMID: 23307959
Article Published Date : Jan 31, 2013
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Endothelial Dysfunction
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Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients.Oct 24, 2018

Pubmed Data : Clin Oral Investig. 2018 Oct 25. Epub 2018 Oct 25. PMID: 30361792
Article Published Date : Oct 24, 2018
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Burning Mouth Syndrome
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Micronized palmitoylethanolamide reduces the symptoms of neuropathic pain in diabetic patients.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Res Treat. 2014 ;2014:849623. Epub 2014 Apr 2. PMID: 24804094
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
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Palmitoylethanolamide adjunctive therapy to citalopram can effectively improve symptoms of patients with major depressive disorder.Feb 20, 2018

Pubmed Data : J Affect Disord. 2018 Feb 21 ;232:127-133. Epub 2018 Feb 21. PMID: 29486338
Article Published Date : Feb 20, 2018
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
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Palmitoylethanolamide and Alpha-lipoic acid are beneficial in treating patients with chronic prostatitis/chronic pelvic pain syndrome.Mar 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Ital Urol Androl. 2017 Mar 31 ;89(1):17-21. Epub 2017 Mar 31. PMID: 28403589
Article Published Date : Mar 30, 2017
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid, Palmitoylethanolamide
Diseases : Chronic Pelvic Pain Syndrome, Prostatitis: Chronic
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Palmitoylethanolamide as adjunctive therapy for autism.Jul 31, 2018

Pubmed Data : J Psychiatr Res. 2018 Aug ;103:104-111. Epub 2018 May 1. PMID: 29807317
Article Published Date : Jul 31, 2018
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Autism
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Palmitoylethanolamide may be an innovative therapeutic intervention as add-on therapy to tapentadol for the management of chronic low back pain.Dec 18, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Anesthesiol. 2017 Dec 19 ;17(1):171. Epub 2017 Dec 19. PMID: 29258432
Article Published Date : Dec 18, 2017
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Low Back Pain
Pharmacological Actions : Analgesics
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Palmitoylethanolamide reduces intraocular pressure and improves visual field indices in individuals affected by normal-tension glaucoma.Aug 31, 2014

Pubmed Data : J Med Food. 2014 Sep ;17(9):949-54. Epub 2014 May 14. PMID: 24827384
Article Published Date : Aug 31, 2014
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Glaucoma
Pharmacological Actions : Antihypertensive Agents
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Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy.Nov 30, 2011

Pubmed Data : CNS Neurol Disord Drug Targets. 2011 Dec ;10(8):916-20. PMID: 22229320
Article Published Date : Nov 30, 2011
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity, Multiple Myeloma
Pharmacological Actions : Chemoprotective Agents
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Research suggests the efficacy and safety of palmitoylethanolamide in the treatment of pain associated with fibromyalgia.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Ther. 2015 Dec ;4(2):169-78. Epub 2015 Sep 3. PMID: 26334329
Article Published Date : Nov 30, 2015
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Fibromyalgia
Pharmacological Actions : Analgesics
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These data suggest that palmitoylethanolamide is effective in treating temporomandibular joint inflammatory pain.Dec 31, 2011

Pubmed Data : J Orofac Pain. 2012 ;26(2):99-104. PMID: 22558609
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Ibuprofen
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Ultra-micronized palmitoylethanolamide effects on sleep-wake rhythm and neuropathic pain phenotypes in patients with carpal tunnel syndrome.Dec 31, 2017

Pubmed Data : CNS Neurol Disord Drug Targets. 2018 ;17(4):291-298. PMID: 29676237
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Carpal Tunnel Syndrome, Chronic Pain, Neuropathic Pain, Sleep Disorders
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Ultra-micronized palmitoylethanolamide slowed down disease progression and disability in Parkinson's disease patients.Dec 31, 2016

Pubmed Data : CNS Neurol Disord Drug Targets. 2017 ;16(6):705-713. PMID: 28325153
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
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Palmitoylethanolamide and luteolin in combination could have beneficial effects in autism.Dec 31, 2016

Pubmed Data : CNS Neurosci Ther. 2017 Jan ;23(1):87-98. Epub 2016 Oct 4. PMID: 27701827
Article Published Date : Dec 31, 2016
Study Type : Animal Study, Human: Case Report
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Autism Spectrum Disorders
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Palmitoylethanolamide treatment led to an improved clinical picture.Oct 31, 2012

Pubmed Data : CNS Neurol Disord Drug Targets. 2012 Nov 1 ;11(7):933-6. PMID: 22998138
Article Published Date : Oct 31, 2012
Study Type : Human: Case Report
Additional Links
Substances : Palmitoylethanolamide
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents
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A formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models.Aug 01, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Vet Res. 2017 Aug 2 ;13(1):229. Epub 2017 Aug 2. PMID: 28768536
Article Published Date : Aug 01, 2017
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide , Quercetin
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
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Administration of palmitoylethanolamide protects the neurovascular unit and reduces secondary injury after traumatic brain injury.Oct 31, 2012

Pubmed Data : Brain Behav Immun. 2012 Nov ;26(8):1310-21. Epub 2012 Aug 3. PMID: 22884901
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
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Co-ultramicronized palmitoylethanolamide and luteolin promotes neuronal regeneration after spinal cord injury.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:47. Epub 2016 Mar 8. PMID: 27014061
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : regen
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Delay of morphine tolerance by palmitoylethanolamide.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:894732. Epub 2015 Mar 22. PMID: 25874232
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice.May 31, 2012

Pubmed Data : J Leukoc Biol. 2012 Jun ;91(6):911-20. Epub 2012 Apr 2. PMID: 22469754
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Intestinal Ischemia
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models.Dec 31, 2013

Pubmed Data : CNS Neurol Disord Drug Targets. 2014 ;13(9):1530-41. PMID: 25106636
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Brain Inflammation
Pharmacological Actions : Neuroprotective Agents, NF-kappaB Inhibitor
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Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(8):e41880. Epub 2012 Aug 17. PMID: 22912680
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
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Palmitoylethanolamide ameliorates hippocampal damage and behavioural dysfunction after perinatal asphyxia.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2018 ;12:145. Epub 2018 Mar 28. PMID: 29662433
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Asphyxia
Pharmacological Actions : Neuroprotective Agents
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Palmitoylethanolamide and luteolin compounds exerts a significant antidepressant effect a low doses.Oct 31, 2013

Pubmed Data : CNS Neurol Disord Drug Targets. 2013 Nov ;12(7):989-1001. PMID: 23844686
Article Published Date : Oct 31, 2013
Study Type : Animal Study
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Antidepressive Agents, Apoptotic
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Palmitoylethanolamide and luteolin may be beneficial in demyelinating disorders such as multiple sclerosis.Aug 17, 2017

Pubmed Data : Mol Neurobiol. 2017 Aug 18. Epub 2017 Aug 18. PMID: 28822061
Article Published Date : Aug 17, 2017
Study Type : Animal Study
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Multiple Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Palmitoylethanolamide and polydatin treatment causes endometriotic lesion regression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:382. Epub 2016 Oct 14. PMID: 27790149
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Endometriosis
Pharmacological Actions : Angiogenesis Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor
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Palmitoylethanolamide and silymarin treatment attenuated the degree of renal inflammation.Sep 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Sep 5 ;762:136-49. Epub 2015 May 14. PMID: 25981305
Article Published Date : Sep 04, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide , Silymarin
Diseases : Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
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Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference.Jan 10, 2018

Pubmed Data : Pharmacol Biochem Behav. 2018 Jan 11 ;166:1-12. Epub 2018 Jan 11. PMID: 29337083
Article Published Date : Jan 10, 2018
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Cocaine Addiction, Cocaine Withdrawal
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Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.Oct 31, 2015

Pubmed Data : Epilepsy Res. 2015 Nov ;117:23-8. Epub 2015 Aug 14. PMID: 26370914
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Cannabinoid Receptors
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Palmitoylethanolamide attenuates the degree of inflammation while preserving the blood-retinal barrier in rats with experimental diabetic retinopathy.Dec 14, 2015

Pubmed Data : Eur J Pharmacol. 2015 Dec 15 ;769:313-23. Epub 2015 Nov 27. PMID: 26607470
Article Published Date : Dec 14, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Diabetic Retinopathy, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
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Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer's disease.Sep 10, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2014 Sep 11 ;5:e1419. Epub 2014 Sep 11. PMID: 25210802
Article Published Date : Sep 10, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Pharmacological Actions : Neuroprotective Agents
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Palmitoylethanolamide could be effective in type 1-diabetic patients not only as pain reliever but also in controlling the development of pathology.Dec 31, 2014

Pubmed Data : CNS Neurol Disord Drug Targets. 2015 ;14(4):452-62. PMID: 25921749
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Analgesics, Pancreato Protective Agents
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Palmitoylethanolamide could represent a novel approach for monitoring pain during trigeminal nerve sensitization.Sep 30, 2018

Pubmed Data : Inflamm Res. 2018 Oct ;67(10):891-901. Epub 2018 Aug 18. PMID: 30121836
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Hyperalgesia, Temporomandibular Joint Disorders
Pharmacological Actions : Analgesics
[+]

Palmitoylethanolamide counteracts autistic-like behaviours in animalsOct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Behav Immun. 2018 Nov ;74:166-175. Epub 2018 Sep 5. PMID: 30193877
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Autism
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Gut-brain Axis
[+]

Palmitoylethanolamide improves colon inflammation.Jul 31, 2014

Pubmed Data : Gut. 2014 Aug ;63(8):1300-12. Epub 2013 Sep 30. PMID: 24082036
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Colitis, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Palmitoylethanolamide improves murine experimental colitis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2015 Jan ;172(1):142-58. Epub 2014 Dec 1. PMID: 25205418
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Cannabinoid Receptors
[+]

Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous inflammation.Feb 14, 2014

Pubmed Data : Eur J Pharmacol. 2014 Feb 15 ;725:64-9. Epub 2014 Jan 16. PMID: 24440533
Article Published Date : Feb 14, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Palmitoylethanolamide may be a potential new treatment for liver fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:709. Epub 2018 Jul 13. PMID: 30057547
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Palmitoylethanolamide may improve inflammation-driven angiogenesis in colonic mucosa.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0156198. Epub 2016 May 24. PMID: 27219328
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Colitis, Colon Cancer: Prevention, Ulcerative Colitis
Pharmacological Actions : Angiogenesis Inhibitors, Chemopreventive, Vascular Endothelial Growth Factor Inhibitors
[+]

Palmitoylethanolamide may play an important role in the mechanisms underlying neonatal anoxia-ischemia.Sep 30, 2018

Pubmed Data : Psychopharmacology (Berl). 2018 Oct ;235(10):2929-2945. Epub 2018 Jul 29. PMID: 30058012
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Anoxia: Brain, Stroke: Neonatal
Pharmacological Actions : Neuroprotective Agents
[+]

Palmitoylethanolamide might be effective in relieving inflammatory and neuropathic pain, especially pain induced by mechanical hyperalgesia.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Anesthesiol. 2017 Oct ;70(5):561-566. Epub 2017 Jul 13. PMID: 29046777
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Inflammation, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Palmitoylethanolamide possesses potential to treat peripheral neuropathy in cancer patients undergoing chemotherapy.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2016 Nov ;359(2):310-318. Epub 2016 Sep 8. PMID: 27608657
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy, Hyperalgesia
Pharmacological Actions : Chemoprotective Agents
[+]

Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats.Mar 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Endocrinology. 2014 Apr ;155(4):1291-301. Epub 2014 Jan 15. PMID: 24428531
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Alcohol Toxicity , Obesity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Ovariectomy-Induced Changes
[+]

Palmitoylethanolamide prevents Parkinsonian phenotypes in aged mice.Mar 18, 2018

Pubmed Data : Mol Neurobiol. 2018 Mar 19. Epub 2018 Mar 19. PMID: 29552727
Article Published Date : Mar 18, 2018
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Neuroprotective Agents, Palmitoylethanolamide, Parkinson's disease
[+]

Palmitoylethanolamide promotes a proresolving macrophage phenotype and attenuates atherosclerotic plaque formation.Oct 31, 2018

Pubmed Data : Arterioscler Thromb Vasc Biol. 2018 Nov ;38(11):2562-2575. PMID: 30354245
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Palmitoylethanolamide protects against the amyloid-β25-35-induced learning and memory impairment.May 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychopharmacology. 2012 Jun ;37(7):1784-92. Epub 2012 Mar 14. PMID: 22414817
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Lipid Peroxidation, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stressOct 31, 2016

Pubmed Data : Pharmacol Res. 2016 Nov ;113(Pt A):276-289. Epub 2016 Sep 8. PMID: 27616549
Article Published Date : Oct 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Neurodegenerative Diseases, Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation
[+]

Palmitoylethanolamide reduces early renal dysfunction and injury caused by experimental ischemia and reperfusion.Sep 30, 2012

Pubmed Data : Shock. 2012 Oct ;38(4):356-66. PMID: 22772472
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.Nov 14, 2016

Pubmed Data : Eur J Pharmacol. 2016 Nov 15 ;791:669-674. Epub 2016 Oct 5. PMID: 27720681
Article Published Date : Nov 14, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Dermatitis: Contact, Inflammation
Pharmacological Actions : Angiogenesis Inhibitors
[+]

Palmitoylethanolamide reduces neuropsychiatric behaviours by restoring cortical electrophysiological activity in a model of mild traumatic brain injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:95. Epub 2017 Mar 6. PMID: 28321191
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice.Aug 11, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Brain. 2015 Aug 12 ;8:47. Epub 2015 Aug 12. PMID: 26260027
Article Published Date : Aug 11, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Palmitoylethanolamide reduces the degree of ocular inflammation in a rat model of endotoxin-induced uveitis.Aug 14, 2015

Pubmed Data : Eur J Pharmacol. 2015 Aug 15 ;761:28-35. Epub 2015 Apr 28. PMID: 25934566
Article Published Date : Aug 14, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Lipid Peroxidation, Lipopolysaccharide-Induced Toxicity, Uveitis
Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Palmitoylethanolamide reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis.Aug 31, 2016

Pubmed Data : Pharmacol Res. 2016 Sep ;111:405-412. Epub 2016 Jul 8. PMID: 27402190
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Palmitoylethanolamide regulates development of intestinal radiation injury in a mast cell-dependent manner.Oct 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dig Dis Sci. 2014 Nov ;59(11):2693-703. Epub 2014 May 22. PMID: 24848354
Article Published Date : Oct 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Radiation Induced Illness: Mucositis
Pharmacological Actions : Radioprotective
[+]

Palmitoylethanolamide supplementation has the potential to prevent the development of asthma-like features.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:857. Epub 2017 Dec 12. PMID: 29311913
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Asthma, Asthma: Prevention
Pharmacological Actions : Anti-Asthmatic Agents
Additional Keywords : Risk Reduction
[+]

Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(5):e0123602. Epub 2015 May 7. PMID: 25951330
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Prophylactic palmitoylethanolamide prolongs survival and decreases detrimental inflammation in aged mice with bacterial meningitis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:2671. Epub 2018 Nov 16. PMID: 30505308
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Meningitis: Bacterial
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Protective effects of ultramicronized palmitoylethanolamide in myocardial ischaemia and reperfusion injury.Dec 31, 2015

Pubmed Data : Shock. 2016 08 ;46(2):202-13. PMID: 26844976
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Myocardial Ischemia
Pharmacological Actions : Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective role of palmitoylethanolamide in contact allergic dermatitis.May 31, 2010

Pubmed Data : Allergy. 2010 Jun 1 ;65(6):698-711. Epub 2009 Nov 11. PMID: 19909294
Article Published Date : May 31, 2010
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Dermatitis: Contact, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats.Oct 04, 2012

Pubmed Data : Brain Res. 2012 Oct 5 ;1477:45-58. Epub 2012 Aug 13. PMID: 23046519
Article Published Date : Oct 04, 2012
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Safety of micronized palmitoylethanolamide and lack of toxicity and genotoxic potential.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2017 Mar ;5(2):292-309. Epub 2016 Jun 15. PMID: 28265364
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Additional Keywords : Safety of Natural Substances
[+]

Subchronic administration of palmitoylethanolamide significantly alleviates seizure intensity, promotes neuroprotection.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Neurosci. 2018 ;11:67. Epub 2018 Mar 14. PMID: 29593494
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

The association of palmitoylethanolamide with luteolin decreases neuroinflammation and stimulates autophagy in Parkinson's disease.Dec 31, 2014

Pubmed Data : CNS Neurol Disord Drug Targets. 2015 ;14(10):1350-65. PMID: 26295827
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Brain Inflammation , Parkinson's Disease
Pharmacological Actions : anti-inflammatory, Autophagy Up-regulation, Neuroprotective Agents
[+]

These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic neuropathic pain.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:711. Epub 2019 Jun 27. PMID: 31316381
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Carnosic Acid, Myrrh, Palmitoylethanolamide
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Ultramicronized palmitoylethanolamide is able to preventing contrast-induced nephropathy in diabetic rats.Jan 04, 2016

Pubmed Data : Toxicol Lett. 2016 Jan 5 ;240(1):10-21. Epub 2015 Oct 21. PMID: 26474837
Article Published Date : Jan 04, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Nephropathy
Pharmacological Actions : Analgesics
[+]

Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease.Jan 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Psychiatry. 2018 Jan 31 ;8(1):32. Epub 2018 Jan 31. PMID: 29382825
Article Published Date : Jan 30, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents
[+]

A review of palmitoylethanolamide in central nervous system health and disease.Jul 31, 2014

Pubmed Data : Pharmacol Res. 2014 Aug ;86:32-41. Epub 2014 May 17. PMID: 24844438
Article Published Date : Jul 31, 2014
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Inflammation, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Palmitoylethanolamide and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia.Dec 31, 2015

Pubmed Data : Brain Res. 2016 10 1 ;1648(Pt A):409-417. Epub 2016 Jul 14. PMID: 27423516
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Brain Ischemia
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

Palmitoylethanolamide blunts amyloid-β42-induced astrocyte activation and improves neuronal survival.Dec 31, 2017

Pubmed Data : J Alzheimers Dis. 2018 ;61(1):389-399. PMID: 29154284
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Palmitoylethanolamide can be explored as a useful tool for preventing or treating the symptoms associated with neuroinflammation in CNS disorders.Mar 22, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 23 ;7(1):375. Epub 2017 Mar 23. PMID: 28336953
Article Published Date : Mar 22, 2017
Study Type : In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Brain Inflammation , Central Nervous System Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Palmitoylethanolamide could be used as a disease-modifying agent for controlling inflammatory responses and related chronic and neuropathic pain.Mar 31, 2014

Pubmed Data : Inflammopharmacology. 2014 Apr ;22(2):79-94. Epub 2013 Nov 1. PMID: 24178954
Article Published Date : Mar 31, 2014
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Inflammation, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Palmitoylethanolamide could be used in the treatment of glaucoma and diabetic retinopathy.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ophthalmol. 2015 ;2015:430596. Epub 2015 Nov 18. PMID: 26664738
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Diabetic Retinopathy, Glaucoma
[+]

Palmitoylethanolamide exerts antiproliferative effect and downregulates VEGF signalling in caco-2 human colon carcinoma cell line.May 31, 2016

Pubmed Data : Phytother Res. 2016 Jun ;30(6):963-70. Epub 2016 Mar 1. PMID: 26929026
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Colon Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors
[+]

Palmitoylethanolamide has potential antidepressant effects alone or in combinations with other classes of antidepressants.Oct 24, 2018

Pubmed Data : J Affect Disord. 2018 Oct 25. Epub 2018 Oct 25. PMID: 30391203
Article Published Date : Oct 24, 2018
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Palmitoylethanolamide in animal model shows potential antidepressant effects.Apr 30, 2014

Pubmed Data : Med Hypotheses. 2014 May ;82(5):507-11. Epub 2014 Mar 3. PMID: 24630855
Article Published Date : Apr 30, 2014
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit.Aug 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2014 Sep ;171(17):4026-37. PMID: 24818658
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Colitis, Inflammation, Irritable Bowel Syndrome
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Palmitoylethanolamide reduces the production of COX-2-derived oxylipins.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res Perspect. 2017 Apr ;5(2):e00300. Epub 2017 Feb 27. PMID: 28357126
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Palmitoylethanolamide should be considered as a new and safe treatment option for nerve compression syndromes.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pain Res. 2015 ;8:729-34. Epub 2015 Oct 23. PMID: 26604814
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Carpal Tunnel Syndrome, Nerve Compression Syndromes
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

Results support the effectiveness and safety of palmitoylethanolamide in flu and respiratory infections.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Inflam. 2013 ;2013:151028. Epub 2013 Aug 27. PMID: 24066256
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Cold: Common, Influenza
Pharmacological Actions : Antiviral Agents
[+]

The available clinical data support the contention that palmitoylethanolamide has analgesic actions.Jan 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Clin Pharmacol. 2016 10 ;82(4):932-42. Epub 2016 Jun 29. PMID: 27220803
Article Published Date : Jan 09, 2016
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

These results show the therapeutic potential of palmitoylethanolamide in models of Alzheimer's disease.Jan 31, 2013

Pubmed Data : CNS Neurol Disord Drug Targets. 2013 Feb 1 ;12(1):62-9. PMID: 23394526
Article Published Date : Jan 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

This review provides an overview of current knowledge of palmitoylethanolamide effect on glial functions in the brain.Jan 31, 2013

Pubmed Data : CNS Neurol Disord Drug Targets. 2013 Feb 1 ;12(1):55-61. PMID: 23394520
Article Published Date : Jan 31, 2013
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Neurodegenerative Diseases, Neuropathic Pain, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents

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