Panax Notoginseng

Name	AC	CK
Cerebral Ischemia	2	22
Diabetic Nephropathy	2	22
Osteoarthritis	3	13
Hydrogen Peroxide Induced Toxicity	2	11
Cerebral Hemorrhage	1	10
DNA damage	1	10
Osteoarthritis: Knee	1	10
Oxidative Stress	6	10
Chemotherapy-Induced Toxicity: Cisplatin	4	8
Alcoholic Liver Disease	3	6
Inflammation	4	6
Lipopolysaccharide-Induced Toxicity	4	6
Alzheimer's Disease	3	5
Brain Ischemia	3	5
Cancers: Drug Resistant	1	5
Nonalcoholic fatty liver disease (NAFLD)	3	5
Ovarian Cancer	1	5
Cardiovascular Diseases	3	4
Fibrosis	2	4
Myocardial Ischemia	2	4
Stroke	2	4
Breast Cancer	2	3
Colorectal Cancer	3	3
Depression	2	3
Diabetic Complications	2	3
Hyperglycemia	2	3
Inflammatory Bowel Diseases	2	3
Liver Cancer	2	3
Lung Cancer	2	3
Osteoporosis	2	3
Ulcerative Colitis	2	3
Wound Healing	2	3
Aging: Heart	1	2
Alcohol Toxicity	1	2
Aspirin-Induced Toxicity	1	2
Brain Injury: Traumatic	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Colitis	1	2
Coxsackievirus Infections	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Fatty Liver	1	2
Hemorrhagic Shock	1	2
Herbicide Toxicity	1	2
Hypertension	1	2
Influenza	1	2
Insulin Resistance	1	2
Liver Cirrhosis	1	2
Liver Damage	1	2
Liver Diseases	1	2
Liver Fibrosis	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocardial Infarction	2	2
Myocarditis: Viral	1	2
Neurodegenerative Diseases	1	2
Pancreatitis	1	2
Pulmonary Fibrosis	1	2
Spinal Cord Injuries	1	2
Stroke: Attenuation/Recovery	1	2
Aging	1	1
Anxiety	1	1
Atherosclerosis	1	1
Bone Fractures	1	1
Candida Albicans	1	1
Cervical Cancer	1	1
Chronic Myeloid Leukemia	1	1
Coronary Artery Disease	1	1
Crohn's Disease	1	1
Encephalopathy	1	1
Escherichia coli Infections	1	1
Heart Failure	1	1
Helicobacter Pylori Infection	1	1
Neuroblastoma	1	1
Obesity	1	1
Pseudomonas aeruginosa	1	1
Radiation Induced Illness	1	1
Staphylococcus aureus infection	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Neuroprotective Agents	19	59
Anti-Inflammatory Agents	18	26
Renoprotective	4	26
Antioxidants	12	25
Hypolipidemic	3	22
Tumor Necrosis Factor (TNF) Alpha Inhibitor	10	19
Interleukin-6 Downregulation	9	17
Cardioprotective	10	16
Hepatoprotective	6	11
Genoprotective	1	10
Anti-Apoptotic	6	9
Antiproliferative	7	8
Chemoprotective Agents	4	8
Chemosensitizer	2	7
Interleukin-1 beta downregulation	4	7
Malondialdehyde Down-regulation	4	7
MicroRNA modulator	4	7
Nrf2 activation	5	7
Anti-metastatic	5	6
Apoptotic	5	5
Wnt/β-catenin pathway down-regulation	1	5
Gastroprotective	2	4
Interleukin-10 upregulation	2	4
Interleukin-4 upregulation	2	4
NF-kappaB Inhibitor	3	4
Superoxide Dismutase Up-regulation	2	4
Angiogenesis Inhibitors	2	3
Antidepressive Agents	2	3
Wnt/β-catenin signaling pathway modulation	2	3
Anti-Fibrotic	1	2
Antihypertensive Agents	1	2
Antineoplastic Agents	2	2
Autophagy Inhibitors	1	2
Brain-derived neurotrophic factor modulator	1	2
Cell cycle arrest	2	2
Enzyme Inhibitors: Pancreatic Amylase	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Hypoglycemic Agents	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Immunostimulatory	1	2
Insulin Sensitizers	1	2
Interleukin-10 downregulation	1	2
Interleukin-8 downregulation	1	2
Nitric Oxide Inhibitor	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Regenerative	1	2
Anti-Adipogenic	1	1
Anti-Anxiety Agents	1	1
Anti-atherogenic	1	1
Antimicrobial	1	1
Autophagy Up-regulation	1	1
Chondroprotective	1	1
Cyclooxygenase 2 Inhibitors	1	1
Heme oxygenase-1 inducer	1	1
Immunomodulatory: Th17 downregulation	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Neurogenesis	1	1
Photoprotective	1	1
Radioprotective	1	1

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Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease.Nov 30, 2020

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Feb;27(2):159-62. PMID: 17343007

Article Published Date : Feb 01, 2007

Study Type : Human Study

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Substances : Panax Notoginseng

Diseases : Cerebral Hemorrhage

Pharmacological Actions : Neuroprotective Agents

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Panax notoginseng supplementation reduces the H2O2-induced DNA damage in the lymphocytes.Sep 30, 2014

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Pubmed Data : J Intercult Ethnopharmacol. 2014 Oct-Dec;3(4):155-8. Epub 2014 Aug 26. PMID: 26401366

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Pubmed Data : Redox Biol. 2022 Jun 24 ;54:102384. Epub 2022 Jun 24. PMID: 35777198

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Pubmed Data : Front Pharmacol. 2021 ;12:615998. Epub 2021 May 7. PMID: 34025400

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Panax Notoginseng

Diseases : Cerebral Ischemia

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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Notoginsenoside R1 may be a potential candidate for Alzheimer's disease treatment.Dec 31, 2014

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Pubmed Data : CNS Neurol Disord Drug Targets. 2015 ;14(3):360-9. PMID: 25714973

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Ginsenosides, Panax Notoginseng

Pharmacological Actions : Neuroprotective Agents

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Notoginsenoside R1 regulates ischemic myocardial lipid metabolism.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:905092. Epub 2022 Jun 22. PMID: 35814216

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides, Panax Notoginseng

Diseases : Heart Disease

Pharmacological Actions : Cardioprotective

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Notoginsenoside R1 reverses abnormal autophagy in hippocampal neurons of mice with sleep deprivation.Dec 31, 2020

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Pubmed Data : Chin J Integr Med. 2021 Jan 15. Epub 2021 Jan 15. PMID: 33449280

Article Published Date : Jan 14, 2021

Study Type : Animal Study

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Substances : Panax Notoginseng

Diseases : Drug-Induced Toxicity: Gastrointestinal

Pharmacological Actions : Gastroprotective

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Panax notoginseng saponin promotes bone regeneration in distraction osteogenesis.Dec 31, 2020

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:2895659. Epub 2021 Oct 21. PMID: 34721625

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Panax Notoginseng

Diseases : Bone Diseases

Pharmacological Actions : Regenerative

Additional Keywords : Bone Regeneration

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Panax notoginseng saponin protects against diabetic cardiomyopathy through lipid metabolism modulation.Feb 14, 2022

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Pubmed Data : J Ethnopharmacol. 2016 Nov 4 ;192:423-430. Epub 2016 Aug 13. PMID: 27620662

Article Published Date : Nov 03, 2016

Study Type : Animal Study

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Substances : Panax Notoginseng

Diseases : Cardiovascular Diseases

Pharmacological Actions : Cardioprotective, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : arteries, Cardiovascular Disease, Heart Health

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Panax notoginseng saponins and two of its main components exert vasodilating effects through the NO and COX pathways.Nov 30, 2016

Article Published Date : Dec 03, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Panax Notoginseng

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , MicroRNA modulator

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Panax notoginseng saponins attenuates cisplatin-induced nephrotoxicity.Dec 31, 2013

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Pubmed Data : Front Pharmacol. 2021 ;12:720368. Epub 2021 Oct 7. PMID: 34690763

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Panax Notoginseng

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative

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Panax notoginseng saponins is capable of improving peritoneal function in subjects with peritoneal dialysis.Dec 31, 2014

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Pubmed Data : Menopause. 2015 Dec ;22(12):1343-50. PMID: 26035148

Article Published Date : Nov 30, 2015

Study Type : Animal Study

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Substances : Panax Notoginseng

Diseases : Osteoarthritis

Additional Keywords : Ovariectomy-Induced Changes

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Panax notoginseng saponins modulate the inflammatory response and improve IBD-like symptoms.Apr 06, 2021

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Pubmed Data : Am J Chin Med. 2021 Apr 7:1-15. Epub 2021 Apr 7. PMID: 33829964

Article Published Date : Apr 06, 2021

Study Type : Animal Study

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Substances : Panax Notoginseng

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor

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Panax notoginseng saponins prevent bone loss by promoting angiogenesis in an osteoporotic mouse model.Dec 31, 2019

Pubmed Data : J Ethnopharmacol. 2016 Aug 22 ;190:301-12. Epub 2016 Jun 8. PMID: 27288754

Article Published Date : Aug 21, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Panax Notoginseng

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Panax notoginseng saponins show renal protection and antioxidative stress effects in diabetic nephropathy.Dec 31, 2021

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Pubmed Data : J Integr Neurosci. 2022 Jun 7 ;21(4):109. PMID: 35864761

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Pubmed Data : Molecules. 2018 Apr 17 ;23(4). Epub 2018 Apr 17. PMID: 29673237

Article Published Date : Apr 16, 2018

Study Type : Review

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Substances : Panax Notoginseng

Diseases : Anxiety, Depression

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents

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A review of Panax notoginseng saponins for treating coronary artery disease.Dec 31, 2016

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Pubmed Data : Front Pharmacol. 2017 ;8:702. Epub 2017 Oct 17. PMID: 29089889

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Panax Notoginseng

Diseases : Coronary Artery Disease

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic

Additional Keywords : Anti-Inflammatory Agents, Coronary Artery Disease, Hypolipidemic, Panax Notoginseng

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A review of protective effects of Panax notoginseng saponins on cardiovascular diseases.Dec 31, 2013

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Effects of panax notoginseng saponins on the osteogenic differentiation of rabbit bone mesenchymal stem cells through TGF-β1 signaling pathwayAug 25, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Aug 26 ;16(1):319. Epub 2016 Aug 26. PMID: 27561678

Article Published Date : Aug 25, 2016

Study Type : In Vitro Study

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Substances : Panax Notoginseng

Diseases : Bone Fractures

Additional Keywords : Mesenchymal Stem Cells, Plant Extracts

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Exploring the mechanism of Panax notoginseng saponins against Alzheimer's disease.Dec 31, 2020

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Pubmed Data : Carbohydr Polym. 2022 Jan 15 ;276:118772. Epub 2021 Oct 18. PMID: 34823789

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Pubmed Data : Am J Chin Med. 2016 ;44(4):851-70. Epub 2016 May 24. PMID: 27222068

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Panax Notoginseng

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic

[+]

Panax notoginseng flower demonstrated a potential herb to treat rats with myocardial infarction.Dec 31, 2018

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Pubmed Data : Cardiol Res Pract. 2019 ;2019:8723076. Epub 2019 May 2. PMID: 31192006

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Panax Notoginseng

Diseases : Myocardial Infarction

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Apoptotic, Cardioprotective

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Additional Keywords : Plant Extracts

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Panax Notoginseng saponins protect cardiac myocytes against endoplasmic reticulum stress and associated apoptosis.Dec 31, 2018

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Pubmed Data : Biomed Res Int. 2018 ;2018:9239354. Epub 2018 Jul 30. PMID: 30151392

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Panax Notoginseng

Diseases : Hyperglycemia

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Panax Notoginseng saponins regulate transforming growth factor- β 1 through MAPK and snail/TWIST1 signaling pathway to inhibit epithelial-mesenchymal transition of pulmonary fibrosis.Dec 31, 2021

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Role of bioactive constituents of Panax notoginseng in the modulation of tumorigenesis.Dec 31, 2020

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Pubmed Data : Front Pharmacol. 2021 ;12:738914. Epub 2021 Oct 27. PMID: 34776959

Article Published Date : Dec 31, 2020

Study Type : Review

Additional Links

Substances : Panax Notoginseng

Diseases : Cancers: All

Pharmacological Actions : Anticarcinogenic Agents

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The antiviral effect of Panax notoginseng polysaccharides by inhibiting PRV adsorption and replication.Feb 12, 2022

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Pubmed Data : CNS Neurol Disord Drug Targets. 2018 ;17(7):547-556. PMID: 29992896

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

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Substances : Panax Notoginseng

Pharmacological Actions : Neurogenesis, Wnt/β-catenin signaling pathway modulation

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View the Evidence: 167 Abstracts with Panax Notoginseng Research

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Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease.Nov 30, 2020

These findings further guide the therapeutic strategy for clinical cerebral ischemic stroke.Dec 31, 2019

A water soluble extract of Panax notoginseng, Rehmannia glutinosa and Eleutherococcus senticosus is safe and effective for symptomatic improvement of pain and physical function in patients with knee osteoarthritis. Feb 01, 2009

Efficacy of the Panax notoginseng suppository in the treatment of patients with ulcerative proctitis.Dec 31, 2021

Panax Notoginseng saponins protect the neuron and promote functional rehabilitation in patients after cerebral hemorrhage. Feb 01, 2007

Panax notoginseng supplementation reduces the H2O2-induced DNA damage in the lymphocytes.Sep 30, 2014

Prevention of deep vein thrombosis by Panax notoginseng saponins combined with low-molecular-weight heparin.Aug 31, 2022

Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells.Nov 03, 2016

Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction.Jun 23, 2022

Panax notoginseng saponins protect brain microvascular endothelial cells against oxygen-glucose deprivation.Oct 31, 2022

Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy.Jan 09, 2023

A combination of Red Sage (Salviae Miltiorrhiza), Panax notoginseny and Dyroblanops aromatica may prevent alcoholic fatty liver disease. Dec 01, 2009

A novel acidic polysaccharide from the residue of Panax notoginseng and its hepatoprotective effect on alcoholic liver damage in mice.Feb 05, 2020

A Panax notoginseng root extract is a promising agent for controlling hyperglycemia by enhancing glucose uptake in skeletal muscle.Oct 23, 2016

Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.Jan 19, 2017

Anti-obesity effect of fermented Panax notoginseng is mediated via modulation of appetite and gut microbial population.Dec 31, 2020

Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide.Aug 31, 2014

Astragalus mongholicus Bunge and Panax notoginseng formula (A&P) improves renal mesangial cell damage in diabetic nephropathy.Jan 19, 2022

Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury.Jan 27, 2020

Cardioprotective effect of stem-leaf saponins from Panax notoginseng on mice With sleep derivation.Dec 31, 2020

Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury.Dec 24, 2020

Components of Astragalus and Panax notoginseng could strengthen the protective effects on cerebral ischemia injury.Dec 31, 2014

Effects of panax notoginseng saponin on the pathological ultrastructure and serum IL-6 and IL-8 in pulmonary fibrosis.Jun 21, 2018

Genes induced by Panax notoginseng in a rodent model of ischemia-reperfusion injury. Dec 31, 2019

Ginsenoside Rd treatment attenuates breast cancer metastasis.Sep 18, 2016

Ginsenoside-Rg1 from Panax notoginseng has a protective effect against lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.Jul 19, 2007

Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats.Aug 01, 2006

Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease.Mar 02, 2021

Hypoglycemic effects of novel Panax notoginseng polysaccharide in mice with diet-induced obesity.Oct 04, 2022

Neutral polysaccharide from Panax notoginseng enhanced cyclophosphamide antitumor efficacy in hepatoma H22-bearing mice.Jan 06, 2021

Notoginsenoside R1 (NG-R1) promoted lymphatic drainage function to ameliorating rheumatoid arthritis.Dec 31, 2020

Notoginsenoside R1 activates the NAMPT-NAD +-SIRT1 cascade to promote postischemic angiogenesis.May 20, 2021

Notoginsenoside R1 alleviates high glucose-induced inflammation and oxidative stress in HUVECs via upregulating miR-147a.Aug 08, 2021

Notoginsenoside R1 alleviates spinal cord injury by inhibiting oxidative stress, neuronal apoptosis, and inflammation.Jan 02, 2022

Notoginsenoside R1 alleviates spinal cord injury.Jun 27, 2022

Notoginsenoside R1 ameliorates cardiac lipotoxicity through AMPK signaling pathway.Dec 31, 2021

Notoginsenoside R1 improves cerebral ischemia/reperfusion injury by promoting neurogenesis.Dec 31, 2020

Notoginsenoside R1 may be a potential candidate for Alzheimer's disease treatment.Dec 31, 2014

Notoginsenoside R1 regulates ischemic myocardial lipid metabolism.Dec 31, 2021

Notoginsenoside R1 reverses abnormal autophagy in hippocampal neurons of mice with sleep deprivation.Dec 31, 2020

Notoginsenoside R1 treatment attenuates BBB permeability, cerebral infarction volume and neurological impairments in rats with acute cerebral ischemia.Aug 31, 2021

Notoginsenoside R2 ameliorated Alzheimer's disease symptoms by reducing neuronal apoptosis and inflammation.Sep 16, 2021

Panax notoginseng alleviates sepsis-induced acute kidney injury.Dec 31, 2021

Panax notoginseng ameliorated albuminuria and podocyte epithelial-mesenchymal transition in diabetic rats.Dec 31, 2019

Panax notoginseng attenuates hypoxia-induced glycolysis in colonic mucosal epithelial cells in DSS-induced colitis.Jan 31, 2022

Panax notoginseng extract and total saponin suppress diet-induced obesity and endoplasmic reticulum stress.Jun 19, 2022

Panax notoginseng extract had protective effects against influenza A virus infection.Dec 31, 2016

Panax Notoginseng has a protective effect against doxorubicin-induced cardiotoxicity in mice. Feb 01, 2008

Panax notoginseng promotes repair of colonic microvascular injury in sprague-dawley rats with experimental colitis.Dec 31, 2017

Panax notoginseng protects the rat brain function from traumatic brain injury.Apr 03, 2021

Panax notoginseng repairs vascular injury in experimental colitis.Dec 20, 2017

Panax notoginseng saponin attenuates gastric mucosal epithelial cell injury induced by dual antiplatelet drugs.Jan 14, 2021

Panax notoginseng saponin promotes bone regeneration in distraction osteogenesis.Dec 31, 2020

Panax notoginseng saponin protects against diabetic cardiomyopathy through lipid metabolism modulation.Feb 14, 2022

Panax notoginseng saponin R1 attenuates allergic rhinitis through AMPK/Drp1 mediated mitochondrial fission.May 23, 2022

Panax notoginseng saponin Rg1 can effectively improve the cognitive function.Dec 31, 2021

Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes.Nov 30, 2022

Panax notoginseng saponins alleviate osteoporosis and joint destruction from antigen-induced arthritis.Oct 31, 2021

Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury.Oct 31, 2022

Panax notoginseng saponins ameliorate Aβ-mediated neurotoxicity in C. elegans through antioxidant activities.Dec 31, 2018

Panax notoginseng saponins ameliorate cisplatin-induced mitochondrial injury via the HIF-1α/mitochondria/ROS pathway.Nov 11, 2019

Panax notoginseng saponins ameliorate impaired arterial vasodilation in rats with metabolic syndrome.Mar 31, 2016

Panax notoginseng saponins ameliorates experimental hepatic fibrosis.Mar 31, 2016

Panax notoginseng saponins and Ginsenoside Rb1 could protect arteries.Nov 03, 2016

Panax notoginseng saponins and two of its main components exert vasodilating effects through the NO and COX pathways.Nov 30, 2016

Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats.Jan 31, 2018

Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice.Nov 30, 2021

Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis.Dec 03, 2016

Panax notoginseng saponins attenuates cisplatin-induced nephrotoxicity.Dec 31, 2013

Panax notoginseng saponins combined with dual antiplatelet drugs potentiates anti-thrombotic effect with alleviated gastric injury.Jul 31, 2022

Panax notoginseng saponins improve recovery after spinal cord transection.Jul 31, 2015

Panax notoginseng saponins improves healing of high glucose-induced wound through the GSK-3β/β-catenin pathway.Apr 05, 2022

Panax Notoginseng

View the Evidence:
167 Abstracts with Panax Notoginseng Research