Papaya

Name	AC	CK
Dengue	11	62
Oxidative Stress	17	33
Thalassemia	2	20
Thrombocytopenia	4	16
Chemically-Induced Liver Damage	7	14
Coronavirus Infection	3	12
Parasitic Diseases	3	12
Inflammation	8	11
Steptococcus Mutans Infections	2	11
Breast Cancer: Prevention	1	10
Cervical Dysplasia	1	10
Diabetes Mellitus: Type 2	6	10
Gingivitis	1	10
Periodontal Diseases	1	10
Skin Ulcer	1	10
Wound Healing	6	10
Cancers: All	5	9
DNA damage	3	6
High Fat Diet	3	6
Breast Cancer	4	5
Obesity	2	4
Burns	2	3
Candida Infection	3	3
Chemotherapy	1	3
Diabetic Complications	2	3
Diabetic Ulcer	2	3
Kidney Damage: Chemically-Induced	2	3
Leukemia	1	3
Liver Cancer	2	3
Prostate Cancer	3	3
Pseudomonas aeruginosa	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging: Brain	1	2
Alcohol Toxicity	1	2
Arsenic Poisoning	1	2
Bacterial Infections and Mycoses	2	2
Benzo[a]pyrene-induced Toxicity	1	2
Chikungunya Virus	2	2
Cognitive Decline/Dysfunction	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Epidural Associated Complications	1	2
Fatty Liver	1	2
Fungal Infection	2	2
Gastric Ulcer	1	2
High Fructose Diet	1	2
Hypercholesterolemia	1	2
Hyperlipidemia	1	2
Hypertension	1	2
Infections	1	2
Iron Overload	1	2
Malaria	1	2
Parasitic Intestinal Diseases	3	2
Pesticide Toxicity	1	2
Prostatic Hyperplasia	1	2
Salmonella Infections	1	2
Uterus: Contraction/Expulsion Disorders	1	2
Wound Healing: Delayed	1	2
Allergies	1	1
Alzheimer's Disease	1	1
Animal Diseases: Infectious	1	1
Bacterial Infections	1	1
Candida Albicans	1	1
Candida Glabrata	1	1
Cardiovascular Diseases	1	1
Casein Intolerance	1	1
Cholangiocarcinoma	1	1
Colon Cancer	1	1
Dengue Fever	1	1
Endothelial Damage	1	1
Endothelial Dysfunction	1	1
Escherichia coli Infections	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Gluten Sensitivity	1	1
Gram-Positive Bacterial Infections	1	1
HIV Infections	1	1
Hyperglycemia	1	1
Immune Dysregulation: TH1/TH2 imbalance	1	1
Influenza	1	1
Ischemia	1	1
Low Disorders: Low TH1	1	1
Lung Cancer	1	1
Metabolic Diseases	1	1
Neurodegenerative Diseases	1	1
Non-Celiac Gluten Sensitivity (NCGS)	1	1
Non-celiac gluten sensitivity (NCGS)	1	1
Organ Transplantation	1	1
Promyelocytic leukemia	1	1
Prostatic Hyperplasia: Benign	1	1
Pseudomonas Infections	1	1
Shigellosis	1	1
Squamous cell carcinoma	1	1
Staphylococcal Infections	1	1
Staphylococcus aureus infection	1	1
Tumors	1	1

Name	AC	CK
Antioxidants	27	73
Antiviral Agents	15	64
Anti-Inflammatory Agents	15	21
Chemopreventive	5	17
Hepatoprotective	7	14
Antiparasitic Agents	4	13
Immunomodulatory	9	13
Interleukin-6 Downregulation	3	13
Antimicrobial	3	12
Contraceptive Agents: Male	1	10
Interleukin-8 downregulation	1	10
Nitric Oxide Inhibitor	1	10
Anti-Bacterial Agents	8	9
Antiproliferative	7	8
Neuroprotective Agents	5	8
Hypolipidemic	4	7
Antineoplastic Agents	2	6
Renoprotective	3	5
Anticarcinogenic Agents	2	4
Cardioprotective	3	4
Chemotherapeutic	2	4
Hypoglycemic Agents	4	4
NF-kappaB Inhibitor	4	4
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	4
Antifungal Agents	3	3
Chemoprotective Agents	1	3
Adrenergic alpha-Agonists	1	2
Alpha-amylase inhibitor	1	2
Alpha-glucosidase inhibitor	1	2
Antimalarials	1	2
Apoptotic	2	2
Cyclooxygenase 2 Inhibitors	1	2
Cytotoxic	2	2
Gastroprotective	1	2
Genoprotective	1	2
Insecticidal	1	2
Interleukin-1 beta downregulation	1	2
Iron Chelating Agents	1	2
MicroRNA modulator	1	2
Prophylactic Agents	1	2
Uterotonic	1	2
Anti-Allergic Agents	1	1
Anti-Angiogenic	1	1
Anti-Apoptotic	1	1
Anti-Ulcer Agents	1	1
Anti-metastatic	1	1
Antihypertensive Agents	1	1
Antimutagenic Agents	1	1
Bcl-2 protein down-regulation	1	1
Cell cycle arrest	1	1
Enzyme Inhibitors	1	1
Immunostimulatory	1	1
Insect Repellents	1	1
Insecticides	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

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Pubmed Data : Phytother Res. 2008 Jun;22(6):820-8. PMID: 18384199

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Jun 10. Epub 2021 Jun 10. PMID: 34109525

Article Published Date : Jun 09, 2021

Study Type : Animal Study

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Substances : Papaya

Diseases : Diabetes Mellitus: Type 2, Epidural Associated Complications

Pharmacological Actions : Cardioprotective

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Papain ameliorates lipid accumulation and inflammation in high-fat diet-induced obesity.Sep 13, 2021

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Pubmed Data : Inflammopharmacology. 2008 Aug;16(4):168-73. PMID: 18759075

Article Published Date : Aug 01, 2008

Study Type : Animal Study

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Substances : Papaya

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

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Papaya promotes significant wound healing in diabetic rats.Aug 01, 2007

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Pubmed Data : Indian J Exp Biol. 2007 Aug;45(8):739-43. PMID: 17877152

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Pubmed Data : J Biomed Biotechnol. 2010;2010:197898. Epub 2010 May 20. PMID: 20508844

Article Published Date : Jan 01, 2010

Study Type : Animal Study

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Substances : Papaya

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The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl 4-induced liver injury in male rats.Dec 29, 2021

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Pubmed Data : Nutrients. 2023 Apr 17 ;15(8). Epub 2023 Apr 17. PMID: 37111148

Article Published Date : Apr 16, 2023

Study Type : Animal Study

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Substances : Papaya, Polyphenols

Diseases : Diabetic Complications, Wound Healing

Additional Keywords : Plant Extracts

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Unripe papaya fruit may be beneficial in gastric ulcer.Dec 01, 2004

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Pubmed Data : Int J Oncol. 2004 Dec;25(6):1809-15. PMID: 20041780

Article Published Date : Dec 01, 2004

Study Type : Animal Study

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Substances : Papaya

Diseases : Gastric Ulcer

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A computational essential dynamics approach to investigate structural influences of ligand binding on Papain like protease from SARS-CoV-2.Jun 27, 2022

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Pubmed Data : BMC Complement Med Ther. 2023 Mar 18 ;23(1):82. Epub 2023 Mar 18. PMID: 36934258

Article Published Date : Mar 17, 2023

Study Type : In Vitro Study

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Substances : Papaya, Pomegranate

Diseases : HIV Infections

Pharmacological Actions : Antioxidants, Antiviral Agents

Additional Keywords : Plant Extracts

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Beneficial role of Carica papaya extracts and phytochemicals on oxidative stress and related diseases.Mar 31, 2021

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Pubmed Data : Appl Biochem Biotechnol. 2023 Mar 29. Epub 2023 Mar 29. PMID: 36988843

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Pubmed Data : J Helminthol. 2007 Dec ;81(4):353-60. Epub 2007 Nov 16. PMID: 18005461

Article Published Date : Nov 30, 2007

Study Type : In Vitro Study

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Substances : Papaya

Diseases : Parasitic Diseases

Pharmacological Actions : Antiparasitic Agents

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Pubmed Data : Ann Med Health Sci Res. 2014 May ;4(3):320-4. PMID: 24971201

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Pubmed Data : J Agric Food Chem. 2007 May 30;55(11):4407-13. Epub 2007 May 1. PMID: 17469845

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Pubmed Data : Br J Nutr. 2002 Aug;88(2):199-203. PMID: 12144723

Article Published Date : Aug 01, 2002

Study Type : Review

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Substances : Papaya

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The potential of papain and alcalase enzymes and process optimizations to reduce allergenic gliadins in wheat flour.Mar 31, 2016

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Pubmed Data : Food Chem. 2016 Apr 1 ;196:1338-45. Epub 2015 Oct 19. PMID: 26593625

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Papaya

Diseases : Non-Celiac Gluten Sensitivity (NCGS)

Problem Substances : Gliadin

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The review clearly demonstrates the successful medical evidence for the use of papaya leaf extracts in the healthcare system.Dec 31, 2021

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:2451733. Epub 2022 Jun 9. PMID: 35720184

Article Published Date : Dec 31, 2021

Study Type : Review

Additional Links

Substances : Papaya

Diseases : Cancers: All, Dengue, Diabetes Mellitus: Type 2, Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Antiproliferative , Antiviral Agents, Hypoglycemic Agents, Immunomodulatory, Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

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Therapeutic application of Carica papaya leaf extract in the management of human diseases. May 04, 2020

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Pubmed Data : Wien Klin Wochenschr. 2005 Aug;117(15-16):558-60. PMID: 15808797

Article Published Date : Aug 01, 2005

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Substances : Papain

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Papaya seeds are effective in the treatment of intestinal parasitosis.Mar 01, 2007

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Pubmed Data : J Med Food. 2007 Mar;10(1):194-6. PMID: 17472487

Article Published Date : Mar 01, 2007

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Substances : Papaya

Diseases : Parasitic Intestinal Diseases

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View the Evidence: 123 Abstracts with Papaya Research

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C. papaya leaf extract can be considered as a potential candidate for increase in platelet count in patients of dengue.Sep 30, 2016

Carica papaya extract in dengue: a systematic review and meta-analysis.Oct 10, 2019

A toothpaste/mouthwash containing Carica papaya leaf extract has beneficial effects on interdental gingival bleeding.Jan 26, 2018

Carica papaya could be an alternative mouthrinse for the inhibition of Streptococcus mutans.Sep 30, 2021

Carica papaya leaf extract increases the platelet count in dengue fever without any side effect and prevents the complication of thrombocytopenia.Dec 31, 2015

Carica papaya seed extract slows human sperm.Sep 14, 2019

Dietary consumption of fruits high in antioxidant nutrients reduce the risk of incident cervical intraepithelial neoplasia.Sep 01, 2010

Fermented Carica papaya and Morinda citrifolia as perspective food supplements for the treatment of post-COVID symptoms.May 24, 2022

Fermented papaya alleviates symptoms associated with oxidative stress in severe forms of thalassemia.Jun 01, 2008

Fermented papaya ameliorates oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia . Feb 01, 2010

Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women.Jul 01, 2009

Papaya seed fortified porridge had a significant effect on reduction of Ascaris lumbricoides burden. Dec 06, 2018

Topical papaya may be effective in treating chronic skin ulcers.Mar 01, 2000

A case study using papaya leaf extract to reverse chemotherapy-induced thrombocytopenia.Dec 31, 2021

The use of natural health products especially papaya leaf extract and dandelion root extract in previously untreated chronic myelomonocytic leukemia.Dec 31, 2017

A comparative study of anti-aging effects of Carica papaya (pulp and seeds) on D-galactose-induced brain aging.Oct 30, 2022

A selenium enriched papaya extract improved wound repair by increasing fibroblasts recruitment.Dec 31, 2014

Alkaloidal extract from Carica papaya seeds ameliorates CCl 4-induced hepatocellular carcinoma.Jul 31, 2021

Ameliorative effect of ethanolic extract of Carica papaya leaves on hyper-cholesterolemic rats.May 31, 2023

Ameliorative effects of Carica papaya extracts against type II diabetes-induced myocardial pathology and dysfunction.Jun 09, 2021

Antioxidant activity of Carica papaya & Persea americana fruits against cadmium induced neurotoxicity, nephrotoxicity, and hepatotoxicity.Nov 01, 2023

Aqueous C. papaya roots preparations might have therapeutic potential as a supplement that can be applied in arsenic poisoning.Mar 31, 2018

Aqueous extracts of C. papaya may be useful in preventing carbon tetrachloride and acetaminophen induced liver toxicities.Dec 31, 2015

C. papaya leaves possesses significant preventive and curative properties against thrombocytopenia.May 31, 2022

C. papaya put back the altered effects in fatty tissue of type 2 diabetic rats by restoring the adipocytokines and the gene expression.Jan 17, 2023

C. papaya was capable of restoring the altered levels in the hepatic tissues of T2DM rats.Feb 28, 2023

Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity.Oct 31, 2023

Carica papaya augments anti-malarial efficacy of artesunate in Plasmodium berghei parasitized mice.Dec 31, 2020

Carica papaya leaf extract inhibits prostatitis-associated prostatic hyperplasia.Feb 28, 2021

Comprehensive assessment of antioxidant and anti-inflammatory properties of papaya extracts.Oct 13, 2022

Effect of Carica papaya extract toward incised wound healing process in mice clinically and histologically.Dec 31, 2018

Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection.Feb 10, 2019

Evaluation of anti-dengue activity of Carica papaya aqueous leaf extract and its role in platelet augmentation.Mar 31, 2019

Fermented papaya ameliorates benzo[a]pyrene mediated genotixicity and oxidative damage.Jan 01, 2006

Fermented papaya extracts can protect the mammary glands and other visceral organs from oxidative damage.Dec 31, 2016

Hypolipidaemic effects of papaya juice on rats fed on a high fat and fructose diet.Dec 31, 2022

Immunomodulatory activities of Carica papaya L. leaf juice in a non-lethal, symptomatic dengue mouse model.Apr 20, 2021

In vitro and in vivo inhibitory effects of Carica papaya seed on α-amylase and α-glucosidase enzymesFeb 29, 2020

Modulatory effect of papaya extract against chlorpyrifos-induced oxidative stress, immune suppression, endocrine disruption, and DNA damage.Jan 11, 2022

Papain ameliorates lipid accumulation and inflammation in high-fat diet-induced obesity.Sep 13, 2021

Papaya juice has antioxidant activity comparable in efficacy and safety to vitamin E (alpha-tocopherol). Jul 01, 2006

Papaya juice reduces mean arterial blood pressure more effectively than hydralazine in hypertensive rats. Jun 01, 2000

Papaya latex extract has uterotonic properties.Jun 01, 2000

Papaya latex gel is effective in the treatment of burns.Dec 01, 2005

Papaya latex: a new paradigm to combat against dengue and filariasis vectors Aedes aegypti and Culex quinquefasciatus.Jan 31, 2018

Papaya leaf extract protects against alcohol induced acute gastric damage and blood oxidative stress in rats.Sep 01, 2008

Papaya leaves exhibit anti-inflammatory properties.Aug 01, 2008

Papaya promotes significant wound healing in diabetic rats.Aug 01, 2007

Papaya protects against chemically-induced liver damage.Dec 01, 2002

Papaya seed extract has immunomodulatory properties.Jan 01, 2003

Papaya seed extract inhibits gene transfer from Salmonella typhimurium to Escherichia coli in vitro and in the digestive tract of gnotobiotic mice.Feb 01, 2005

Phytochemical extract from Carica papaya leaves and Punica granatum seeds as therapy against cognitive impairment.Aug 25, 2023

Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity.Nov 16, 2022

Safety Study: Papaya.Jan 01, 2010

The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl 4-induced liver injury in male rats.Dec 29, 2021

The antioxidant effect of fermented papaya preparation involves iron chelation.Mar 31, 2012

Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin.Dec 31, 2022

This study concludes that different parts of the papaya can be beneficial for preventing diabetes and diabetes-related wound healing.Apr 16, 2023

Unripe papaya fruit may be beneficial in gastric ulcer.Dec 01, 2004

A computational essential dynamics approach to investigate structural influences of ligand binding on Papain like protease from SARS-CoV-2.Jun 27, 2022

A review of evolving herbal formulations in management of dengue fever.Aug 31, 2017

A review of phytotherapy in diabetic foot ulcers.Apr 24, 2022

Allergenicity reduction of cow's milk proteins using latex peptidases (from papaya).Jun 29, 2019

Analysis of Phytonutrients, anti-mutagenic and chemopreventive effects of tropical fruit extracts.Oct 26, 2021

Anti-inflammatory and anti-oxidative effects of polysaccharides extracted from unripe Carica papaya.Jul 26, 2023

Antibacterial efficacy of Carica papaya leaf extract, probiotics, kidodent, and placebo mouthwashes.Jun 30, 2021

Anticancer potential of Carica papaya Linn black seed extract against human colon cancer cell line.Jul 28, 2023

Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection.Mar 17, 2023

Beneficial role of Carica papaya extracts and phytochemicals on oxidative stress and related diseases.Mar 31, 2021

Benzyl isothiocyanate is the chief or sole anthelmintic in papaya seed extracts.Jun 01, 2001

Bromelain and papain exhibit anti-flu virion properties.May 01, 2008

Bromelain and papain have cytotoxic effects on human cholangiocarcinoma cell lines.Apr 30, 2016

Papaya

View the Evidence:
123 Abstracts with Papaya Research