Parthenolide

Name	AC	CK
Colorectal Cancer	10	17
Breast Cancer	12	13
Inflammation	9	13
Breast Cancer: Triple Negative	9	10
Lipopolysaccharide-Induced Toxicity	6	9
Lung Cancer	6	9
Cancers: All	7	7
Cancers: Drug Resistant	7	7
Oral Cancer	2	7
Brain Inflammation	3	6
Liver Cancer	4	6
Melanoma	5	6
Periodontitis	2	6
Arthritis	3	5
Endometriosis	3	5
Cervical Cancer	4	4
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Diabetes Mellitus: Type 2	2	4
Fibrosis	2	4
Lymphoma	3	4
Multiple Sclerosis	2	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Obesity	2	4
Sepsis	2	4
Thyroid Cancer	3	4
Acute Myeloid Leukemia	3	3
Acute lymphoblastic leukemia (ALL)	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Cerebral Ischemia	2	3
Diabetic Nephropathy	2	3
Gastric Cancer	3	3
Alzheimer's Disease	1	2
Asthma	1	2
Bone Diseases	1	2
Brain Ischemia	1	2
Cachexia: Cancer	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Colitis	1	2
Colon Surgery	1	2
Colonic Anastomoses	1	2
Coronavirus Infection	2	2
Diabetes: Cognitive Dysfunction	1	2
Gastric Ulcer	1	2
Hepatitis	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Insulin Resistance	1	2
Intracerebral Hemorrhage	1	2
Kidney Damage	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Multiple Myeloma	2	2
Neuropathic Pain	1	2
Neuropathies	1	2
Osteoarthritis: Knee	1	2
Osteoarthrosis	1	2
Prostate Cancer	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Stroke	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Acute T cell Leukemias	1	1
Air Pollution Linked Toxicity	1	1
Cancer Metastasis	1	1
Cataract	1	1
Chronic Myeloid Leukemia	1	1
Cognitive Decline/Dysfunction	1	1
Colon Cancer	1	1
Coronavirus Disease (Covid-19)	1	1
Esophageal Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
Herpes Simplex Virus Type 1	1	1
High Cholesterol	1	1
High Sugar Diet	1	1
Hyperlipidemia	1	1
Hypoxia	1	1
Inflammatory Bowel Diseases	1	1
Kaposi's Sarcoma	1	1
Kidney Cancer	1	1
Leishmaniasis	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: T-cell acute Lymphoblastic	1	1
Liver Fibrosis	1	1
Lung Injury: Acute	1	1
Malaria	1	1
Medulloblastoma	1	1
Muscle Disorders	1	1
Nasopharyngeal Cancer	1	1
Nicotine/Tobacco Toxicity	1	1
Osteoporosis	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1
Oxidative Stress	1	1
Pancreatic Cancer	1	1
Periodontal Diseases	1	1
Plasmodium Infections	1	1
Pseudomonas aeruginosa	1	1
Skin Cancer	1	1
Skin Diseases: Inflammatory	1	1
Spinal Cord Injuries	1	1

Name	AC	CK
Anti-Inflammatory Agents	33	58
Apoptotic	43	57
NF-kappaB Inhibitor	33	50
Antiproliferative	36	48
Tumor Necrosis Factor (TNF) Alpha Inhibitor	16	31
Chemotherapeutic	18	25
Antioxidants	11	17
Interleukin-1 beta downregulation	10	16
Neuroprotective Agents	9	15
Interleukin-6 Downregulation	8	13
Anti-metastatic	6	11
Antineoplastic Agents	9	10
Bcl-2 protein down-regulation	5	9
Chemosensitizer	9	9
Anti-Apoptotic	6	8
Autophagy Up-regulation	6	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	7
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	7
Vascular Endothelial Growth Factor Inhibitors	5	7
Bcl-xL down-regulation	2	6
Cell cycle arrest	5	6
Transforming growth factor beta (TGF-β) inhibitor	4	6
Cyclooxygenase 2 Inhibitors	4	5
Immunomodulatory	3	5
Nrf2 activation	3	5
Wnt/β-catenin pathway down-regulation	1	5
Analgesics	2	4
Chemoprotective Agents	2	4
Cytotoxic	4	4
Postaglandin PGE2 downregulation	2	4
Renoprotective	2	4
Angiogenesis Inhibitors	2	3
Anti-Fibrotic	2	3
Chemopreventive	2	3
Hepatoprotective	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	3
Immunomodulatory: Th17 downregulation	2	3
Anti-Cachexic Agents	1	2
Anti-Ulcer Agents	1	2
Anticarcinogenic Agents	1	2
Antiviral Agents	2	2
Autophagy Inhibitors	2	2
Cyclooxygenase 1 Inhibitor	1	2
Heme oxygenase-1 up-regulation	1	2
Insulin Sensitizers	1	2
Interleukin-17 downregulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-8 downregulation	2	2
Osteoprotective	1	2
Radioprotective	1	2
Radiosensitizer	1	2
SIRT1 Activator	1	2
STAT3 Inhibitor	2	2
Anticholesteremic Agents	1	1
Antimalarials	1	1
Enzyme Inhibitors	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Heat Shock Protein Inducer	1	1
Histone deacetylase inhibitor	1	1
Interleukin-1 alpha downregulation	1	1
Interleukin-10 upregulation	1	1
Interleukin-18 down-regulation	1	1
Interleukin-2 Downregulation	1	1
Leishmanicidal	1	1
Quorum Sensing Inhibition	1	1
Survivin Down-Regulation	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Parthenolide is a strong apoptotic inducer that deserves the further investigations for potential chemotherapeutic agent of human oral cancers.May 31, 2015

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Pubmed Data : Oral Oncol. 2015 Jun ;51(6):602-9. Epub 2015 Mar 26. PMID: 25817195

Article Published Date : May 31, 2015

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Parthenolide

Diseases : Oral Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic

[+]

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Pubmed Data : Mol Cell Biochem. 2017 Aug 12. Epub 2017 Aug 12. PMID: 28801714

Article Published Date : Aug 11, 2017

Study Type : Animal Study

Additional Links

Substances : Parthenolide

Diseases : Oral Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Apoptotic, Chemopreventive

[+]

Parthenolide administration alleviated some of the pathological changes in asthma.Jan 31, 2017

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Pubmed Data : Allergol Immunopathol (Madr). 2017 Jan - Feb;45(1):63-68. Epub 2016 Oct 4. PMID: 27717727

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Pubmed Data : Int Immunopharmacol. 2016 Sep ;38:132-8. Epub 2016 Jun 4. PMID: 27270078

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 ;46(sup3):S931-S942. Epub 2018 Oct 11. PMID: 30307334

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides, Parthenolide

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Parthenolide and resveratrol significantly improved healing and mechanical stability of colonic anastomoses in rats during the early postoperative period.Feb 11, 2010

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Pubmed Data : J Surg Res. 2010 Feb 11. Epub 2010 Feb 11. PMID: 20605167

Article Published Date : Feb 11, 2010

Study Type : Animal Study

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Substances : Parthenolide, Resveratrol

Diseases : Colon Surgery, Colonic Anastomoses

Pharmacological Actions : NF-kappaB Inhibitor

[+]

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Pubmed Data : Int Immunopharmacol. 2023 Jun ;119:110229. Epub 2023 May 9. PMID: 37167640

Article Published Date : May 31, 2023

Study Type : Animal Study

Additional Links

Substances : Parthenolide

Diseases : Colitis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue.Nov 07, 2023

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Pubmed Data : Chem Biol Interact. 2023 Nov 8 ;387:110793. Epub 2023 Nov 8. PMID: 37949423

Article Published Date : Nov 07, 2023

Study Type : Animal Study

Additional Links

Substances : Parthenolide

Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2015 Sep ;388(9):921-30. Epub 2015 May 15. PMID: 25971793

Article Published Date : Aug 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Lipopolysaccharide-Induced Toxicity, Skin Diseases: Inflammatory

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Parthenolide as cooperating agent for anti-cancer treatment of various malignancies.Aug 13, 2020

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Pubmed Data : Intervirology. 2018 Jul 12:1-9. Epub 2018 Jul 12. PMID: 30001535

Article Published Date : Jul 11, 2018

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Herpes Simplex Virus Type 1

Pharmacological Actions : Antiviral Agents

[+]

Parthenolide exerts cytotoxic effects on breast cancer stem-like cells.Apr 13, 2016

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Pubmed Data : Mol Cancer. 2017 Jan 30 ;16(1):13. Epub 2017 Jan 30. PMID: 28137265

Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells.Dec 31, 2014

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Pubmed Data : Theranostics. 2015 ;5(3):302-21. Epub 2015 Jan 1. PMID: 25553117

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

Additional Keywords : Cancer Stem Cells

[+]

Parthenolide inhibits hydrogen peroxide-induced apoptosis in human lens epithelial cells.Dec 31, 2017

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Parthenolide may influence the biological behavior of human thyroid cancer cells.Apr 01, 2022

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Pubmed Data : Toxicol Lett. 2013 Aug 14 ;221(2):73-82. Epub 2013 Jun 20. PMID: 23792430

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Pubmed Data : Cell Oncol (Dordr). 2017 Jun ;40(3):263-279. Epub 2017 Apr 20. PMID: 28429280

Article Published Date : May 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Medulloblastoma

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Phytochemicals may serve as novel therapeutic agents for breast cancer treatment.Sep 30, 2016

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Pubmed Data : Semin Cancer Biol. 2016 Oct ;40-41:192-208. Epub 2016 Sep 5. PMID: 27609747

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Pubmed Data : J Cell Physiol. 2015 Jun ;230(6):1276-89. PMID: 25370819

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Pubmed Data : Iran J Basic Med Sci. 2020 May ;23(5):616-622. PMID: 32742599

Article Published Date : Apr 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Acute T cell Leukemias, Lymphoma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Targeting thioredoxin reductase by parthenolide contributes to inducing apoptosis of HeLa cells.May 05, 2016

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Pubmed Data : Front Pharmacol. 2023 ;14:1111218. Epub 2023 Mar 9. PMID: 37033622

Article Published Date : Dec 31, 2022

Study Type : Review

Additional Links

Substances : Parthenolide

Diseases : Arthritis, Cancers: All, Coronavirus Disease (Covid-19), Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Storm

[+]

These data offer fundamental evidence supporting the potential use of parthenolide in periodontitis treatment.Dec 31, 2013

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View the Evidence: 142 Abstracts with Parthenolide Research

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Parthenolide is a potential novel therapeutic agent for aggressive colorectal cancer treatment.Mar 31, 2017

Parthenolide is a strong apoptotic inducer that deserves the further investigations for potential chemotherapeutic agent of human oral cancers.May 31, 2015

Parthenolide may be a promising component for bone regeneration in periodontitis treatment.Aug 21, 2017

Parthenolide suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability.Sep 22, 2023

A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.Dec 31, 2019

Anticancer activities of parthenolide in primary effusion lymphoma preclinical models.Jun 07, 2021

Assessing the effects of parthenolide on inflammation, bone loss, and glial cells within a collagen antibody-induced arthritis model.Dec 31, 2019

Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice.Feb 28, 2022

Nano parthenolide improves intestinal barrier function of sepsis.Dec 31, 2022

Oral administration of parthenolide completely prevented tumor formation and significantly reduced the severity of histopathological changes.Aug 11, 2017

Parthenolide administration alleviated some of the pathological changes in asthma.Jan 31, 2017

Parthenolide alleviates indomethacin-induced gastric ulcerMay 03, 2024

Parthenolide alleviates microglia-mediated neuroinflammation.Jun 30, 2023

Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation.Nov 30, 2022

Parthenolide alleviates peritoneal fibrosis.Dec 11, 2019

Parthenolide ameliorates Concanavalin A-induced acute hepatitis.Aug 31, 2016

Parthenolide ameliorates diabetes-induced behavioural deficit, neurotransmitter imbalance and neuroinflammation in type 2 diabetes rat model.Feb 28, 2017

Parthenolide ameliorates intracerebral hemorrhage-induced brain injury in rats.Sep 08, 2019

Parthenolide ameliorates neurological deficits and neuroinflammation in traumatic brain injury.Jun 30, 2022

Parthenolide ameliorates obesity and obesity-induced inflammatory responses.Jun 30, 2019

Parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis.Dec 31, 2017

Parthenolide and resveratrol significantly improved healing and mechanical stability of colonic anastomoses in rats during the early postoperative period.Feb 11, 2010

Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain.Nov 30, 2023

Parthenolide attenuated bleomycin-induced pulmonary fibrosis.Jan 04, 2018

Parthenolide attenuates sepsis-induced acute kidney injury.Dec 31, 2022

Parthenolide complements the cell death-inducing activity of doxorubicin in melanoma cells.Jul 31, 2013

Parthenolide could down-regulate the blood IL-1beta and TNF-alpha concentrations in model of knee osteoarthritis. Sep 30, 2013

Parthenolide directly or indirectly attenuates neuropathy symptoms and promotes M2 microglia/macrophages polarization.Dec 31, 2014

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemiaFeb 20, 2013

Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer.Apr 30, 2014

Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells.Oct 30, 2013

Parthenolide has potential therapeutic value for bone destructive disorders that are associated with increased bone resorption.Jul 31, 2014

Parthenolide inhibited the growth and migration of MDA-T32 human papillary thyroid carcinoma cells.Jul 07, 2019

Parthenolide inhibits human lung cancer cell growth.Aug 31, 2020

Parthenolide inhibits the growth of non-small cell lung cancer by targeting epidermal growth factor receptor.Nov 22, 2020

Parthenolide may be useful as a potential alternative or adjunct therapy for inflammatory arthritis.Apr 30, 2015

Parthenolide might be a candidate agent for preventing NAFLD due to its anti-inflammatory and anti-oxidative potency.Jul 31, 2017

Parthenolide modulates cerebral ischemia-induced microglial polarization and alleviates neuroinflammatory injury.Sep 30, 2022

Parthenolide modulates immune response in cells from C57BL/6 mice induced with experimental autoimmune encephalomyelitis.Apr 30, 2017

Parthenolide phytosomes attenuated gentamicin-induced nephrotoxicity.Mar 16, 2023

Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease.Jun 30, 2021

Parthenolide promotes renal tubules albumin uptake in type 2 diabetic nephropathy.Mar 30, 2020

Parthenolide protected the brain from damage caused by middle cerebral artery occlusion.Dec 31, 2012

Parthenolide reduces cell proliferation and prostaglandin E2 [corrected] in human endometriotic stromal cells and inhibits development of endometriosis.Sep 30, 2013

Parthenolide reduces tumor burden and alleviates cachexia symptoms.Aug 14, 2013

Parthenolide repressed endometriosis.Oct 14, 2023

Parthenolide selectively sensitizes prostate tumor tissue to radiotherapy while protecting healthy tissues in vivo.Apr 30, 2017

Parthenolide suppresses T helper 17 and alleviates experimental autoimmune encephalomyelitis.Dec 31, 2021

Parthenolide targets NLRP3 to treat inflammasome-related diseases.May 31, 2023

Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue.Nov 07, 2023

These results demonstrate that parthenolide potentiates the efficacy of balsalazide.Jan 31, 2017

Anticancer and apoptotic activities of parthenolide in combination with epirubicin in mda-mb-468 breast cancer cells.Jul 19, 2020

Cytokine storm in COVID-19 and parthenolide: Preclinical evidence.May 29, 2020

A review of the combined effect of parthenolide and various anti-cancer drugs.Dec 31, 2013

Combination treatment with parthenolide and balsalazide may offer an effective strategy for the induction of apoptosis in HCT116 cells.Jun 30, 2015

First discovery of cholesterol-lowering activity of parthenolide.Sep 22, 2022

It may be possible to achieve greater toxicity to T cell acute lymphoblastic leukemia by combining parthenolide with inhibitors of cystine uptake.May 16, 2018

Novel targeted nano-parthenolide molecule against NF-kB in acute myeloid leukemia.Jun 02, 2019

Overexpression of RIP3 sensitizes MCF-7 and MDA-MB-231 breast cancer cells to parthenolide in vitro.Jun 30, 2014

Parthenolide alleviates cognitive dysfunction and neurotoxicity.Nov 20, 2023

Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner.Dec 31, 2019

Parthenolide ameliorates fibrogenesis and inflammation in hepatic fibrosis.Sep 30, 2021

Parthenolide and its soluble analogues: multitasking compounds with antitumor properties.Feb 20, 2022

Parthenolide appears to attenuate the microbial product-mediated inflammatory skin diseases. Aug 31, 2015

Parthenolide as cooperating agent for anti-cancer treatment of various malignancies.Aug 13, 2020

Parthenolide attenuates cerebral ischemia/reperfusion injury.Apr 30, 2017

parthenolide can be developed as a drug used in combination therapy against melanoma.Feb 22, 2016

Parthenolide can exert anti-cancer effects by inducing cell apoptosis, activating autophagy and inhibiting cell proliferation.Dec 31, 2013

Parthenolide can serve as a potential chemotherapeutic agent for pancreatic cancer.Dec 31, 2016

Parthenolide could be a novel candidate for cancer treatment.Dec 31, 2018

Parthenolide could become a promising and stable drug with anti-inflammatory effects.Dec 31, 2014

Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells.Jul 17, 2019

Parthenolide

View the Evidence:
142 Abstracts with Parthenolide Research