Perilla

Name	AC	CK
Cognitive Decline/Dysfunction	4	24
IgA Nephropathy	1	21
Aging: Brain	2	20
Oxidative Stress	11	15
Inflammation	12	14
Aging	3	13
Athletic Performance	2	11
Cardiovascular Diseases	2	11
Chronic Pain	1	10
Dyspepsia	1	10
Hypertension	1	10
Osteoarthritis	1	10
Asthma	5	9
Lipopolysaccharide-Induced Toxicity	6	9
Alzheimer's Disease	5	8
Colitis	4	8
High Fat Diet	4	8
Obesity	4	7
Depression	4	6
Diabetes Mellitus: Type 2	3	6
Aging Skin	3	5
Cancers: All	4	5
Ultraviolet Radiation Induced Damage	3	5
Allergic Rhinitis	2	4
Breast Cancer	3	4
Insomnia	2	4
Lung Cancer	4	4
Atopic Dermatitis	2	3
Brain Inflammation	2	3
Colorectal Cancer	2	3
Diabetic Nephropathy	2	3
Gastrointestinal Inflammation	2	3
Hair Loss	2	3
Hyperglycemia	3	3
Inflammatory Bowel Diseases	2	3
Lung Damage	1	3
Parkinson's Disease	2	3
Psoriasis	2	3
Acute Respiratory Distress Syndrome	1	2
Air Pollution Linked Toxicity	2	2
Allergic Rhinoconjunctivitis	1	2
Allergies	2	2
Arthritis	1	2
Bacillus subtilis infections	2	2
Brain: Oxidative Stress	2	2
Breast Cancer: Triple Negative	2	2
Chemotherapy	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chronic Obstructive Pulmonary Disease	1	2
Colon Cancer	1	2
Coronavirus Disease (Covid-19)	2	2
Dementia	1	2
Diabetes: Oxidative Stress	1	2
Dioxin Toxicity	1	2
Dysbiosis	1	2
Dyslipidemias	1	2
Furan Toxicity	1	2
Gastric Ulcer	1	2
HIV Infections	2	2
Helicobacter Pylori Infection	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperlipidemia	1	2
Hypersensitivity: Immediate	1	2
Hyperuricemia	2	2
Ileitis	1	2
Kidney Fibrosis	1	2
Lipid Peroxidation	1	2
Liver Cancer	1	2
Memory Disorders: Sleep Deprivation Induced	1	2
Osteoporosis	2	2
Photooxidative Stress	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thrombosis	1	2
Ulcerative Colitis	1	2
Advanced Glycation End products (AGE)	1	1
Alopecia: Androgenic	1	1
Cancer Metastasis	1	1
Central Nervous System Diseases	1	1
Chemically-Induced Liver Damage	1	1
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	1
Coronavirus Infection	1	1
Cough	1	1
Covid: Long	1	1
DNA damage	1	1
Diabetic Retinopathy	1	1
Ebola	1	1
Escherichia coli Infections	1	1
Fatigue	1	1
Fungal Infection	1	1
Gram-Negative Bacterial Infections	1	1
Hepatoma	1	1
Herpes Simplex Virus Type 1	1	1
Influenza	1	1
Leukemia	1	1
Listeria Infections	1	1
Lung Inflammation	1	1
Lung Injury: Acute	1	1
Neurodegenerative Diseases	1	1
Oral Cancer	1	1
Periodontitis	1	1
Pseudomonas aeruginosa	1	1
Respiratory Diseases	1	1
Salmonella Infections	1	1
Severe Acute Respiratory Syndrome	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1
Trichophytosis	1	1

Name	AC	CK
Anti-Inflammatory Agents	48	86
Antioxidants	24	41
Neuroprotective Agents	14	39
Gastrointestinal Agents	5	26
Interleukin-6 Downregulation	14	26
Renoprotective	2	23
Tumor Necrosis Factor (TNF) Alpha Inhibitor	9	16
NF-kappaB Inhibitor	8	14
Cardioprotective	3	12
Osteoprotective	3	12
Antihypertensive Agents	2	11
Interleukin-1 beta downregulation	6	11
Analgesics	1	10
Antiproliferative	8	10
Cyclooxygenase 2 Inhibitors	6	10
Anti-Allergic Agents	4	6
Antidepressive Agents	4	6
Hypoglycemic Agents	4	6
Alpha-glucosidase inhibitor	4	5
Anti-Bacterial Agents	4	5
Chemoprotective Agents	3	5
Malondialdehyde Down-regulation	3	5
Nitric Oxide Inhibitor	3	5
Anti-Apoptotic	2	4
Anti-Asthmatic Agents	2	4
Antiviral Agents	4	4
Apoptotic	4	4
Gastroprotective	2	4
Hypnotics and Sedatives	2	4
Interleukin-8 downregulation	2	4
Photoprotective	2	4
Anti-metastatic	3	3
Brain-derived neurotrophic factor modulator	2	3
Cell cycle arrest	3	3
Immunomodulatory	2	3
Acetylcholinesterase Inhibitor	1	2
Alpha-amylase inhibitor	2	2
Anti-Fibrotic	1	2
Anti-thrombotic	1	2
Antimicrobial	2	2
Antitussive Agents	1	2
Chemotherapeutic	1	2
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	2
Hypolipidemic	1	2
Interferon Gamma Reducer	1	2
Interleukin-1 alpha downregulation	1	2
Interleukin-23 Downregulation	1	2
Interleukin-6 upregulation	1	2
Leukotriene Antagonists	1	2
STAT3 Inhibitor	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Tyrosinase inhibitors	1	2
Anti-Glycation Agents	1	1
Antifungal Agents	1	1
Chemopreventive	1	1
Chemosensitizer	1	1
Hepatoprotective	1	1
Immunomodulatory: Th17 downregulation	1	1
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
P21 Activation	1	1
Reverse Transcriptase Inhibitors	1	1
Xanthine oxidase inhibitor	1	1

Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals.Feb 15, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Funct. 2022 Feb 16. Epub 2022 Feb 16. PMID: 35171190

Article Published Date : Feb 15, 2022

Study Type : Human Study

Additional Links

Substances : Nobiletin , Perilla

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

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Perilla frutescens leaf extracts alleviate acute lung injury in mice by inhibiting KAT2A.Jan 09, 2025

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Pubmed Data : J Ethnopharmacol. 2025 Jan 10 ;336:118730. Epub 2024 Aug 23. PMID: 39181280

Pubmed Data : Fukuoka Igaku Zasshi. 1999 May;90(5):171-83. PMID: 10396873

Article Published Date : May 01, 1999

Study Type : Animal Study

Additional Links

Substances : Broccoli, Cabbage, Chives, Kale, Onion, Perilla , Spinach, Vegetables: All

Diseases : Dioxin Toxicity , Furan Toxicity

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Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra.Oct 27, 2020

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Cold-pressed perilla seed oil: Investigating its protective influence on the gut-brain axis in mice with rotenone-induced Parkinson's disease.Aug 31, 2024

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Pubmed Data : Food Sci Nutr. 2024 Sep ;12(9):6259-6283. Epub 2024 Jun 14. PMID: 39554352

Article Published Date : Aug 31, 2024

Study Type : Animal Study

Additional Links

Substances : Perilla

Diseases : Parkinson's Disease

Pharmacological Actions : Gastrointestinal Agents, Neuroprotective Agents

Additional Keywords : Gut-brain Axis

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Effects of Perilla frutescens var. acuta in amyloid β toxicity and Alzheimer's disease-like pathology in 5XFAD mice.Feb 28, 2022

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Pubmed Data : Food Chem Toxicol. 2022 Mar ;161:112847. Epub 2022 Feb 7. PMID: 35143918

Article Published Date : Feb 28, 2022

Study Type : Animal Study

Additional Links

Substances : Perilla

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

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Effects of perilla seed pomace extract on aging-induced cognitive dysfunction.Jun 11, 2025

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Pubmed Data : Nutr Res Pract. 2018 Feb ;12(1):20-28. Epub 2018 Jan 12. PMID: 29399293

Article Published Date : Jan 31, 2018

Study Type : Animal Study

Additional Links

Substances : Perilla

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

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Perilla frutescens sprout extract may be useful for the prevention or treatment of diabetic nephropathy.Feb 07, 2019

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Pubmed Data : Nutrients. 2019 Feb 8 ;11(2). Epub 2019 Feb 8. PMID: 30744045

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Pubmed Data : Arch Esp Urol. 2024 Dec ;77(10):1162-1171. PMID: 39763256

Article Published Date : Nov 30, 2024

Study Type : Animal Study

Additional Links

Substances : Perilla

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, NF-kappaB Inhibitor

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These findings position perilla seed residue crude extract as a promising supplement for the management of diabetes.Aug 21, 2025

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Pubmed Data : Molecules. 2023 Apr 12 ;28(8). Epub 2023 Apr 12. PMID: 37110648

Article Published Date : Apr 11, 2023

Study Type : In Vitro Study

Additional Links

Substances : Perilla

Diseases : Breast Cancer: Triple Negative , Cancer Metastasis

Pharmacological Actions : Anti-metastatic

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Anti-hair loss potential of Perilla seed extracts: In vitro molecular insights from supercritical fluid extraction.Jul 22, 2025

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Pubmed Data : Foods. 2025 Jul 23 ;14(15). Epub 2025 Jul 23. PMID: 40807520

Article Published Date : Jul 22, 2025

Study Type : In Vitro Study

Additional Links

Substances : Perilla

Diseases : Hair Loss

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Antiasthmatic compounds targeting β2-adrenergic receptor from Perilla frutescens improved lung inflammation.Nov 01, 2022

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Pubmed Data : J Nat Prod. 2022 Nov 2. Epub 2022 Nov 2. PMID: 36322828

Article Published Date : Nov 01, 2022

Study Type : In Vitro Study

Additional Links

Substances : Perilla

Diseases : Asthma, Lung Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Antidepressant effect of Perilla frutescens essential oil.Jan 09, 2024

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Pubmed Data : J Ethnopharmacol. 2024 Jan 10 ;318(Pt A):116840. Epub 2023 Jun 23. PMID: 37355083

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Pubmed Data : Med Mycol J. 2021 ;62(4):79-87. PMID: 34853254

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Lemongrass, Perilla

Diseases : Bacillus subtilis infections

Pharmacological Actions : Antimicrobial

Additional Keywords : Essential Oils, Natural Substance Synergy

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Luteolin and Perilla frutescens can modulate the signaling cascades that regulate Spike S1-induced lung inflammation during the incidence of Long-COVID.Dec 31, 2021

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Pubmed Data : Front Med (Lausanne). 2022 ;9:1072056. Epub 2023 Jan 9. PMID: 36698809

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Luteolin, Perilla

Diseases : Coronavirus Disease (Covid-19), Covid: Long

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

Additional Keywords : Long Covid

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Pubmed Data : Biotechnol Appl Biochem. 2021 Sep 7. Epub 2021 Sep 7. PMID: 34490944

Article Published Date : Sep 06, 2021

Study Type : In Vitro Study

Additional Links

Substances : Perilla , Rosmarinic acid

Diseases : Bacillus subtilis infections, Escherichia coli Infections, Salmonella Infections, Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

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The antiviral potential of Perilla frutescens: Advances and perspectives. Jul 14, 2024

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View the Evidence: 117 Abstracts with Perilla Research

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The effects of Perilla frutescens extracts on IgA nephropathy. Jul 09, 2023

Effectiveness of a nutraceutical supplement containing highly standardized perilla and ginger extracts in patients with functional dyspepsia.Feb 29, 2020

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain.Dec 31, 2022

Perilla frutescens leaf powder intake may be an effective intervention to prevent cardiovascular diseases.Apr 29, 2020

Perilla oil intake may improve gut function and microbiota in athletes.Jun 15, 2022

Perilla seed oil enhances cognitive function and mental health in healthy elderly Japanese individuals by enhancing the biological antioxidant potential.May 18, 2021

Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults.Jan 12, 2023

Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals.Feb 15, 2022

Perilla frutescens leaf extracts alleviate acute lung injury in mice by inhibiting KAT2A.Jan 09, 2025

A diet containing P. frutescens extract effectively reversed learning and memory impairment induced by trimethyltin chloride.Oct 26, 2015

A flavanone derivative Perilla frutescens potently suppresses IgE-mediated immediate hypersensitivity reactions.Jan 28, 2017

A variety of vegetables reduce the absorption and enhance excretion of dioxin and furan toxins. May 01, 1999

Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra.Oct 27, 2020

Anti-inflammatory and antioxidative effects of Perilla frutescens-derived extracellular vesicles: Insights from Zebrafish models.May 31, 2025

Anti-inflammatory effect of Perilla frutescens seed oil rich in omega-3 fatty acid on dextran sodium sulfate-induced colitis in mice.Sep 30, 2021

Anti-neuroinflammation effect of standardized ethanol extract of leaves of Perilla frutescens var. acuta on Aβ-Induced Alzheimer's disease.Aug 11, 2025

Cold-pressed extraction of perilla seed oil enriched with alpha-linolenic acid mitigates tumour progression and restores gut microbial homeostasis.Dec 31, 2023

Cold-pressed perilla oil has therapeutic potential in terms of protecting against skin photo-aging.Feb 21, 2020

Cold-pressed perilla seed oil: Investigating its protective influence on the gut-brain axis in mice with rotenone-induced Parkinson's disease.Aug 31, 2024

Effects of Perilla frutescens var. acuta in amyloid β toxicity and Alzheimer's disease-like pathology in 5XFAD mice.Feb 28, 2022

Effects of perilla seed pomace extract on aging-induced cognitive dysfunction.Jun 11, 2025

Essential oil of P. frutescens administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression.Sep 30, 2014

Fermented Perilla frutescens ameliorates depression-like behavior in sleep-deprivation-induced stress model.Dec 29, 2022

Fermented Perilla frutescens may have beneficial effects on SD-induced cognitive impairment by protecting against oxidative stress and increasing BDNF expression.Dec 05, 2024

Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice.Sep 30, 2022

Nanogel loaded with Perilla frutescens leaf-derived exosome-like nanovesicles and indomethacin for the treatment of inflammatory arthritis.Jul 31, 2025

Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf.Jan 14, 2024

Omega-3 fatty acids (fish and perilla oil) are beneficial for small intestine inflammation associated with ileitis. Dec 01, 2009

P. frutescens leaf exhibits excellent hypoglycemic activity in vitro and in vivo.Feb 02, 2021

Perilla fruit water extract can be a potential drug to assist the treatment of airway respiratory distress syndrome.Dec 31, 2021

Perilla frutescens and its active compound rosmarinic acid have beneficial effects on cognitive improvement and may help prevent Alzheimer's disease.May 31, 2016

Perilla frutescens and rosmarinic acid may play a role in ameliorating allergy diseases.Jan 01, 2011

Perilla frutescens exerts a protective effect against testicular damage by attenuating oxidative stress induced by busulfan.Sep 30, 2024

Perilla frutescens extracts protects against dextran sulfate sodium-induced murine colitis.Dec 31, 2016

Perilla frutescens leaf could be a potential therapeutic agent and food supplement for NSAID-induced gastric injuries.Dec 31, 2018

Perilla frutescens leaves attenuate dextran sulfate sodium-induced acute colitis.Dec 31, 2019

Perilla frutescens leaves extract ameliorates ultraviolet radiation-induced extracellular matrix damage.Jan 03, 2017

Perilla frutescens sprout displays beneficial effects in the prevention and treatment of type 2 diabetes.Jan 31, 2018

Perilla frutescens sprout extract may be useful for the prevention or treatment of diabetic nephropathy.Feb 07, 2019

Perilla increases glucagon-like peptide secretion.May 01, 2008

Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet.Dec 01, 2009

Perilla leaf extract attenuates asthma airway inflammation by blocking the syk pathway.Dec 31, 2020

Perilla leaf extract attenuates COPD airway inflammation.Dec 31, 2020

Perilla leaf extract prevents atopic dermatitis induced by an extract of Dermatophagoides farinae in NC/Nga mice.Nov 30, 2016

Perilla oil alleviates high-fat diet-induced inflammation in the colon. Jul 31, 2020

Perilla oil and α-linolenic acid ameliorated thrombosis.May 31, 2023

Perilla seed oil Alleviates gut dysbiosis, intestinal inflammation and metabolic disturbance.Sep 08, 2021

Perilla seed oil demonstrates anti-asthmatic effects. Jan 01, 2007

Protective effect of perilla oil against dextran sodium sulfate-induced colitis.Oct 31, 2022

Protective effect of perilla seed meal and perilla seed extract against dextran sulfate Sodium-induced ulcerative colitis.Apr 23, 2024

Purple perilla showed lipid lowering in adipocyte cells and prevented body weight gain in mice.Aug 31, 2018

Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway.Nov 23, 2020

Sedative effects of inhaled Perilla frutescens essential oils.Feb 11, 2021

The anti-tussive, anti-inflammatory effects and sub-chronic toxicological evaluation of perilla seed oil.Mar 14, 2021

The essential oil derived from Perilla frutescens attenuates imiquimod-induced psoriasis-like skin lesions.May 06, 2022

The extract of Perilla frutescens seed residue attenuated the progression of aberrant crypt foci in rat colon.Feb 25, 2023

The promotion of hair regrowth by topical application of a Perilla frutescens extract.Dec 31, 2017

The role and mechanism of perilla alcohol in counteracting doxorubicin-induced nephrotic syndrome. Nov 30, 2024

These findings position perilla seed residue crude extract as a promising supplement for the management of diabetes.Aug 21, 2025

These findings suggest that perilla seed oil has the potential to reduce the risk of metabolic syndrome.Apr 16, 2025

This suggests that Perilla frutescens leaf can counteract vascular dementia-associated structural and functional deterioration.Jan 07, 2022

Water extracts of perilla leaves could significantly suppress Th2 responses and airway inflammation in allergic murine model of asthma.Dec 31, 2014

A methoxyflavanone derivative from Perilla frutescens induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma.Jul 13, 2017

A methoxyflavanone from Perilla frutescens induces cellular senescence in A549 human lung adenocarcinoma cells.Aug 17, 2022

An ethanol extract of Perilla frutescens leaves suppresses adrenergic agonist-induced metastatic ability of cancer cells.Apr 11, 2023

Anti-hair loss potential of Perilla seed extracts: In vitro molecular insights from supercritical fluid extraction.Jul 22, 2025

Anti-inflammatory activity of the constituents from the leaves of Perilla frutescens.Nov 27, 2023

Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells.Sep 30, 2018

Anti-inflammatory effects of Perilla frutescens in activated human neutrophils.Dec 13, 2015

Anti-obesity activities of the compounds from Perilla frutescens and chemical profiling of the extract.May 22, 2024

Anti-osteoporosis effect of Perilla frutescens leaf hexane fraction through regulating osteoclast and osteoblast differentiation.Jan 25, 2022

Antiasthmatic compounds targeting β2-adrenergic receptor from Perilla frutescens improved lung inflammation.Nov 01, 2022

Perilla

View the Evidence:
117 Abstracts with Perilla Research