Perilla

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17 Diseases Researched for Perilla
NameACCKFocus
Asthma24Locked
Allergic Rhinitis12Locked
Allergic Rhinoconjunctivitis12Locked
Cognitive Decline/Dysfunction12Locked
Depression12Locked
Dioxin Toxicity 12Locked
Dyslipidemias12Locked
Furan Toxicity 12Locked
Ileitis12Locked
Obesity12Locked
Fungal Infection11Locked
Gram-Negative Bacterial Infections11Locked
HIV Infections11Locked
Hepatoma11Locked
Leukemia11Locked
Pseudomonas aeruginosa11Locked
Trichophytosis11Locked
18 Pharmacological Actions Researched for Perilla
NameACCKFocus
Anti-Inflammatory Agents36Locked
Anti-Allergic Agents12Locked
Antidepressive Agents12Locked
Apoptotic22Locked
Cyclooxygenase 2 Inhibitors12Locked
Glucagon Like peptide 1 (GLP-1) Up-regulation12Locked
Immunomodulatory12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-6 Downregulation12Locked
Interleukin-6 upregulation12Locked
Leukotriene Antagonists12Locked
NF-kappaB Inhibitor12Locked
Neuroprotective Agents12Locked
Anti-Bacterial Agents11Locked
Antifungal Agents11Locked
Antiproliferative 11Locked
Cell cycle arrest11Locked
Reverse Transcriptase Inhibitors11Locked

View the Evidence:
40 Abstracts with Perilla Research

[+]

Effectiveness of a nutraceutical supplement containing highly standardized perilla and ginger extracts in patients with functional dyspepsia.Feb 29, 2020

Pubmed Data : Minerva Gastroenterol Dietol. 2020 Mar ;66(1):35-40. PMID: 32283883
Article Published Date : Feb 29, 2020
Study Type : Human Study
Additional Links
Substances : Ginger, Perilla
Diseases : Dyspepsia
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Plant Extracts
[+]

Perilla frutescens leaf powder intake may be an effective intervention to prevent cardiovascular diseases.Apr 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Apr 30 ;25(9). Epub 2020 Apr 30. PMID: 32365849
Article Published Date : Apr 29, 2020
Study Type : Human Study
Additional Links
Substances : Alpha Linolenic Acid, Perilla
Diseases : Cardiovascular Diseases, Hypertension
Pharmacological Actions : Antihypertensive Agents, Cardioprotective
[+]

A diet containing P. frutescens extract effectively reversed learning and memory impairment induced by trimethyltin chloride.Oct 26, 2015

Pubmed Data : J Med Food. 2015 Oct 27. Epub 2015 Oct 27. PMID: 26505950
Article Published Date : Oct 26, 2015
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

A flavanone derivative Perilla frutescens potently suppresses IgE-mediated immediate hypersensitivity reactions.Jan 28, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 01 29 ;483(1):674-679. Epub 2016 Dec 13. PMID: 27986566
Article Published Date : Jan 28, 2017
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Allergic Rhinitis, Hypersensitivity: Immediate
Pharmacological Actions : Anti-Allergic Agents
[+]

A variety of vegetables reduce the absorption and enhance excretion of dioxin and furan toxins. May 01, 1999

Pubmed Data : Fukuoka Igaku Zasshi. 1999 May;90(5):171-83. PMID: 10396873
Article Published Date : May 01, 1999
Study Type : Animal Study
Additional Links
Substances : Broccoli, Cabbage, Chives, Kale, Onion, Perilla , Spinach, Vegetables: All
Diseases : Dioxin Toxicity , Furan Toxicity
[+]

Cold-pressed perilla oil has therapeutic potential in terms of protecting against skin photo-aging.Feb 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Feb 22 ;25(4). Epub 2020 Feb 22. PMID: 32098445
Article Published Date : Feb 21, 2020
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Aging Skin, Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
Additional Keywords : Plant Oils
[+]

Essential oil of P. frutescens administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression.Sep 30, 2014

Pubmed Data : Chin J Nat Med. 2014 Oct ;12(10):753-9. Epub 2014 Oct 31. PMID: 25443368
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
Additional Keywords : Essential Oils
[+]

Omega-3 fatty acids (fish and perilla oil) are beneficial for small intestine inflammation associated with ileitis. Dec 01, 2009

Pubmed Data : Clin Exp Immunol. 2009 Dec;158(3):325-33. Epub 2009 Sep 30. PMID: 19793338
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Omega-3 Fatty Acids, Perilla
Diseases : Ileitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 upregulation
[+]

Perilla frutescens and its active compound rosmarinic acid have beneficial effects on cognitive improvement and may help prevent Alzheimer's disease.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2016 Jun ;10(3):274-81. Epub 2016 Apr 1. PMID: 27247723
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Perilla , Rosmarinic acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor
[+]

Perilla frutescens and rosmarinic acid may play a role in ameliorating allergy diseases.Jan 01, 2011

Pubmed Data : Exp Biol Med (Maywood). 2011 Jan;236(1):99-106. PMID: 21239739
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Perilla , Rosmarinic acid
Diseases : Allergic Rhinitis, Allergic Rhinoconjunctivitis
Pharmacological Actions : Anti-Allergic Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Perilla frutescens extracts protects against dextran sulfate sodium-induced murine colitis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:482. Epub 2017 Aug 8. PMID: 28848431
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, STAT3 Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Perilla frutescens leaf could be a potential therapeutic agent and food supplement for NSAID-induced gastric injuries.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:9514703. Epub 2019 Mar 4. PMID: 30949513
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Perilla , Rosemaric Acid
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Gastroprotective
Problem Substances : Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Perilla frutescens leaves attenuate dextran sulfate sodium-induced acute colitis.Dec 31, 2019

Pubmed Data : Food Sci Biotechnol. 2020 Jan ;29(1):131-140. Epub 2019 Nov 25. PMID: 31976135
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Perilla frutescens leaves extract ameliorates ultraviolet radiation-induced extracellular matrix damage.Jan 03, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jan 4 ;195:334-342. Epub 2016 Nov 22. PMID: 27888134
Article Published Date : Jan 03, 2017
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Perilla frutescens sprout displays beneficial effects in the prevention and treatment of type 2 diabetes.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2018 Feb ;12(1):20-28. Epub 2018 Jan 12. PMID: 29399293
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Perilla frutescens sprout extract may be useful for the prevention or treatment of diabetic nephropathy.Feb 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Feb 8 ;11(2). Epub 2019 Feb 8. PMID: 30744045
Article Published Date : Feb 07, 2019
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Perilla increases glucagon-like peptide secretion.May 01, 2008

Pubmed Data : Biol Pharm Bull. 2008 May;31(5):1021-3. PMID: 18451539
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Perilla
Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation
[+]

Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet.Dec 01, 2009

Pubmed Data : Phytother Res. 2009 Dec;23(12):1685-90. PMID: 19444921
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Dyslipidemias, Obesity
[+]

Perilla leaf extract prevents atopic dermatitis induced by an extract of Dermatophagoides farinae in NC/Nga mice.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Allergy Immunol. 2016 Dec ;34(4):272-277. PMID: 27001658
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Perilla seed oil demonstrates anti-asthmatic effects. Jan 01, 2007

Pubmed Data : Planta Med. 2007 Jan;73(1):53-8. PMID: 17315310
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Asthma
Pharmacological Actions : Leukotriene Antagonists
[+]

Purple perilla showed lipid lowering in adipocyte cells and prevented body weight gain in mice.Aug 31, 2018

Pubmed Data : J Food Sci. 2018 Sep ;83(9):2384-2393. Epub 2018 Aug 2. PMID: 30070698
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Perilla , Rosmarinic acid
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Hypolipidemic
Additional Keywords : Anti-Obesity Agents, Phytotherapy, Plant Extracts
[+]

The promotion of hair regrowth by topical application of a Perilla frutescens extract.Dec 31, 2017

Pubmed Data : J Nat Med. 2018 Jan ;72(1):96-105. Epub 2017 Sep 13. PMID: 28905175
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Hair Loss
Additional Keywords : Hair Regeneration
[+]

Water extracts of perilla leaves could significantly suppress Th2 responses and airway inflammation in allergic murine model of asthma.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:324265. Epub 2015 Apr 20. PMID: 26064160
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
Additional Keywords : Plant Extracts
[+]

A methoxyflavanone derivative from Perilla frutescens induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma.Jul 13, 2017

Pubmed Data : Cytotechnology. 2017 Jul 14. Epub 2017 Jul 14. PMID: 28710570
Article Published Date : Jul 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells.Sep 30, 2018

Pubmed Data : Fitoterapia. 2018 Oct ;130:61-65. Epub 2018 Aug 16. PMID: 30121232
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-inflammatory effects of Perilla frutescens in activated human neutrophils.Dec 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 Dec 14 ;5:18204. Epub 2015 Dec 14. PMID: 26659126
Article Published Date : Dec 13, 2015
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Co-administration with nilotinib and perilla-derived methoxyflavanone significantly suppressed in vivo tumorigenicity of A549 cells in mice.Jul 28, 2017

Pubmed Data : Cytotechnology. 2017 Jul 29. Epub 2017 Jul 29. PMID: 28756527
Article Published Date : Jul 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
[+]

Drying the leaves of Perilla frutescens increases their content of anticancer nutraceuticals.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2019 Apr ;7(4):1494-1501. Epub 2019 Mar 18. PMID: 31024723
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Luteolin, Perilla
Diseases : Cancers: All
[+]

Extracts of Ficus carica and Perilla frutescens have potential for attenuating pathogens.Dec 31, 2013

Pubmed Data : Chemotherapy. 2014 ;60(5-6):379-83. Epub 2015 Oct 24. PMID: 26496663
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Fig, Perilla
Diseases : Gram-Negative Bacterial Infections, Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Gene Expression Regulation, Multidrug Resistance, Plant Extracts
[+]

Isolation, characterization, and xanthine oxidase inhibitory activities of flavonoids from the leaves of Perilla frutescens.Jan 01, 2019

Pubmed Data : Nat Prod Res. 2019 Jan 2:1-7. Epub 2019 Jan 2. PMID: 30600717
Article Published Date : Jan 01, 2019
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Hyperuricemia
Pharmacological Actions : Xanthine oxidase inhibitor
[+]

Melissa, Sweet Basil, Perilla, Prunella vulgaris and Savory has anti-HIV-1 activity. Jan 01, 1986

Pubmed Data : Zh Mikrobiol Epidemiol Immunobiol. 1986 Jan;(1):62-5. PMID: 9743251
Article Published Date : Jan 01, 1986
Study Type : In Vitro Study
Additional Links
Substances : Basil: Sweet, Melissa (Lemonbalm), Perilla , Prunella vulgaris, Savory
Diseases : HIV Infections
Pharmacological Actions : Reverse Transcriptase Inhibitors
Additional Keywords : Plant Extracts
[+]

Neuroprotective effect of Perilla extracts on PC12 cells.Jun 30, 2016

Pubmed Data : J Med Assoc Thai. 2016 Jul ;99 Suppl 4:S256-64. PMID: 29927179
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Alzheimer's Disease, Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Neuroprotective effect of polysaccharide separated from Perilla frutescens.Apr 07, 2018

Pubmed Data : Biosci Biotechnol Biochem. 2018 Apr 8:1-15. Epub 2018 Apr 8. PMID: 29629628
Article Published Date : Apr 07, 2018
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents
Additional Keywords : Polysaccharides
[+]

Perilla leaf extract inhibits growth and induces programmed cell death in human hepatoma cells. Jul 25, 2007

Pubmed Data : J Ethnopharmacol. 2007 Jul 25;112(3):557-67. Epub 2007 May 10. PMID: 17574356
Article Published Date : Jul 25, 2007
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Hepatoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Perilla leaf induces programmed cell death and cell cycle arrest in human leukemia cells. Jun 01, 2009

Pubmed Data : J Med Food. 2009 Jun;12(3):508-17. PMID: 19627198
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Perilla nutlet extracts may have potential to protect endothelium against vascular inflammation.May 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2020 May 29 ;40(5). PMID: 32426811
Article Published Date : May 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Cardiovascular Diseases, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phytochemical and phytopharmacological review of Perilla frutescens L. Sep 30, 2017

Pubmed Data : Food Chem Toxicol. 2017 Oct ;108(Pt B):375-391. Epub 2016 Nov 24. PMID: 27890564
Article Published Date : Sep 30, 2017
Study Type : Review
Additional Links
Substances : Perilla
Diseases : Allergies, Cancers: All, Cough, Depression, Oxidative Stress
Pharmacological Actions : Anti-Allergic Agents, Antidepressive Agents, Antimicrobial, Antioxidants
Additional Keywords : Phytotherapy
[+]

The present review considers the literature on the effects of botanicals on BDNF. Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2017 ;2017:5965371. Epub 2017 Dec 31. PMID: 29464125
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Ashwagandha, Bacopa, Coffee, Ginkgo biloba, Ginseng, Ginseng (Siberian), Grapes, Green Tea, Olive Oil, Perilla , Red Sage, Rhodiola (Tibetan Ginseng), Saffron
Diseases : Central Nervous System Diseases
Pharmacological Actions : Brain-derived neurotrophic factor modulator
[+]

The vapors from Oregano, Perilla, Tea Tree, Lavender, Clove, and Geranium essential oils have antifungal activity against Trichophyton mentagrophytes. Dec 01, 2006

Pubmed Data : J Infect Chemother. 2006 Dec;12(6):349-54. Epub 2007 Jan 18. PMID: 17235639
Article Published Date : Dec 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Clove, Geranium, Lavender, Oregano, Perilla , Tea Tree
Diseases : Fungal Infection, Trichophytosis
Pharmacological Actions : Antifungal Agents
[+]

These findings suggest that P. frutescens var. japonica and rosmarinic acid could prevent the progression of neurodegenerative diseases.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2016 May 1 ;24(3):338-45. PMID: 27133263
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Perilla , Rosmarinic acid
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents

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