Phloretin

Name	AC	CK
Oxidative Stress	11	20
Acne	2	11
Inflammation	9	11
Aging Skin	1	10
Ulcerative Colitis	5	10
Ultraviolet Radiation Induced Damage	1	10
Insulin Resistance	6	9
Parkinson's Disease	3	9
Endothelial Dysfunction	5	8
Diabetes Mellitus: Type 2	4	7
Liver Cancer	6	7
Melanoma	3	7
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	7
Alzheimer's Disease	3	6
Colorectal Cancer	2	6
Diabetic Complications	3	6
Air Pollution Linked Toxicity	1	5
Brain Inflammation	3	5
Breast Cancer	4	5
Colon Cancer	5	5
Experimental Lung Inflammation	1	5
Advanced Glycation End products (AGE)	3	4
Atherosclerosis	3	4
Hyperuricemia	2	4
Lipopolysaccharide-Induced Toxicity	3	4
Obesity	3	4
Osteoporosis	3	4
Cancers: All	3	3
Cancers: Drug Resistant	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Cardiomyopathy	2	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Chemotherapy-Induced Toxicity: Doxorubicin	1	3
Chronic Obstructive Pulmonary Disease	2	3
Endothelial Damage	1	3
Escherichia coli Infections	2	3
High Fat Diet	2	3
Liver Damage	2	3
Multiple Sclerosis	2	3
Nonalcoholic fatty liver disease (NAFLD)	1	3
Oral Cancer	3	3
Prostatic Hyperplasia: Benign	2	3
Salmonella Infections	3	3
Arsenic Poisoning	1	2
Arthritis	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Brain Ischemia	1	2
Breast Cancer: Triple Negative	1	2
Candida Albicans	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Arsenic Trioxide	2	2
Colitis	1	2
Depression	1	2
Diabetic Nephropathy	1	2
Diabetic Neuropathy	1	2
Gastric Cancer	2	2
Glioblastoma	2	2
Gram-Negative Bacterial Infections	2	2
Heart Failure	1	2
Hepatic Steatosis	1	2
Kidney Damage	1	2
Listeria Infections	2	2
Lung Cancer	2	2
Lung Inflammation	1	2
Memory Disorders	1	2
Mitochondrial Dysfunction	1	2
Myocardial Infarction	1	2
Neurodegenerative Diseases	1	2
Osteoarthritis	1	2
Prostate Cancer	2	2
Sepsis	1	2
Skin Cancer	1	2
Staphylococcus aureus infection	2	2
Bacterial Infections	1	1
Cancer Metastasis	1	1
Cancers: Multi-Drug Resistant	1	1
Cardiovascular Diseases	1	1
Cervical Cancer	1	1
Esophageal Cancer	1	1
Gastrointestinal Inflammation	1	1
Haemophilus influenzae	1	1
Hepatoma	1	1
Hyperglycemia	1	1
Infection: Antibiotic Resistant	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lipid Peroxidation	1	1
Liver Cirrhosis	1	1
Liver Damage: Aflatoxin-Induced	1	1
Liver Fibrosis	1	1
Macular Degeneration	1	1
Pancreatic Cancer	1	1
Pseudomonas aeruginosa	1	1
Rheumatoid Arthritis	1	1
Steptococcus Mutans Infections	1	1
Streptococcus pneumoniae infection	1	1
Streptococcus pyogenes	1	1
Thrombosis	1	1
Traumatic Brain Injury	1	1
Tuberculosis	1	1
Vulvovaginitis: Infectious	1	1

Name	AC	CK
Anti-Inflammatory Agents	37	59
Antioxidants	27	55
Antiproliferative	22	29
Anti-Bacterial Agents	10	24
Cyclooxygenase 2 Inhibitors	7	23
NF-kappaB Inhibitor	12	23
Apoptotic	21	22
Interleukin-6 Downregulation	12	22
Interleukin-1 beta downregulation	9	20
Neuroprotective Agents	8	18
Prostaglandin PGE2 downregulation	4	18
Tumor Necrosis Factor (TNF) Alpha Inhibitor	8	14
Antimicrobial	3	12
Hepatoprotective	7	12
Cardioprotective	5	10
Hypoglycemic Agents	6	10
Photoprotective	1	10
Anti-metastatic	5	9
Chemopreventive	7	9
Immunomodulatory	6	9
Interleukin-8 downregulation	4	9
Nrf2 activation	6	9
Cell cycle arrest	8	8
Chemotherapeutic	2	6
Gastrointestinal Agents	3	6
Hypolipidemic	3	6
Renoprotective	3	6
Tumor Suppressor Protein p53 Upregulation	2	6
Chemoprotective Agents	4	5
Malondialdehyde Down-regulation	3	5
Angiogenesis Inhibitors	3	4
Anti-Apoptotic	3	4
Anti-Fibrotic	2	4
Bcl-2 protein down-regulation	3	4
Prophylactic Agents	3	4
Anti-Glycation Agents	2	3
Anticarcinogenic Agents	2	3
Antineoplastic Agents	3	3
Cytoprotective	3	3
Glucose transporter-2 (GLUT2) expression down-regulation	2	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	3
Osteoprotective	2	3
Superoxide Dismutase Up-regulation	2	3
Acetylcholinesterase Inhibitor	1	2
Adiponectin upregulation	1	2
Aldose reductase inhibitor	1	2
Anti-atherogenic	1	2
Antidepressive Agents	1	2
Autophagy Up-regulation	2	2
Brain-derived neurotrophic factor modulator	1	2
Catalase Up-Regulation	1	2
Chemosensitizer	2	2
Heme oxygenase-1 up-regulation	1	2
Insulin Sensitizers	1	2
Interferon Gamma Reducer	1	2
Interleukin-17 downregulation	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
Nitric Oxide Inhibitor	1	2
Nootropic Agents	1	2
Postaglandin PGE2 downregulation	2	2
STAT3 Inhibitor	1	2
Alpha-glucosidase inhibitor	1	1
Anti-Angiogenic	1	1
Anti-Infective Agents	1	1
Antiviral Agents	1	1
Autophagy Inhibitors	1	1
Heme oxygenase-1 inducer	1	1
Immunosuppressive Agents	1	1
Interleukin-12 downregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
P-glycoprotein Inhibitors	1	1
Phase I Detoxification Enzyme Inducer	1	1
Phase II Detoxification Enzyme Inducer	1	1
Quorum Sensing Inhibition	1	1
Remyelination	1	1
Survivin Down-Regulation	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1

[+]

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

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Pubmed Data : Int J Cosmet Sci. 2016 Feb ;38(1):85-92. Epub 2015 Aug 30. PMID: 26212527

Article Published Date : Jan 31, 2016

Study Type : Human In Vitro, Human Study

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Substances : Phloretin

Diseases : Acne

Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Protective effects of a topical antioxidant mixture against ultraviolet-induced photodamage in human skin.Nov 30, 2008

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Pubmed Data : J Cosmet Dermatol. 2008 Dec ;7(4):290-7. PMID: 19146606

Article Published Date : Nov 30, 2008

Study Type : Human Study

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Substances : Ferulic acid, Phloretin, Vitamin C

Diseases : Aging Skin, Ultraviolet Radiation Induced Damage

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Antioxidants, Photoprotective

[+]

Antioxidant mixtures could prevent the harmful effects of ozone induced oxidative stress in human keratinocytes.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(8):e0131097. Epub 2015 Aug 13. PMID: 26270818

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Pubmed Data : Phytomedicine. 2020 Jan ;66:153111. Epub 2019 Oct 16. PMID: 31790902

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

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Substances : Phloretin

Diseases : Hyperuricemia, Kidney Damage

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Renoprotective

[+]

Phloretin ameliorates testosterone-induced benign prostatic hyperplasia.Jul 25, 2021

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Pubmed Data : Int Immunopharmacol. 2017 Dec 12 ;55:112-119. Epub 2017 Dec 12. PMID: 29245072

Article Published Date : Dec 11, 2017

Study Type : Animal Study

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Substances : Phloretin

Diseases : Chronic Obstructive Pulmonary Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation

[+]

Phloretin is able to inhibit NSCLC A549 cell growth by inducing apoptosis.Nov 30, 2015

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Pubmed Data : Oncol Rep. 2015 Dec ;34(6):2871-9. PMID: 26503828

Article Published Date : Nov 30, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Phloretin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Phloretin may be a potent reagent for hepatocellular carcinoma treatment. Oct 15, 2019

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Pubmed Data : J Nutr Biochem. 2014 Dec ;25(12):1296-308. Epub 2014 Sep 16. PMID: 25283330

Article Published Date : Nov 30, 2014

Study Type : Animal Study

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Substances : Phloretin

Diseases : Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

Problem Substances : Insulin

[+]

Phloretin protects against cardiac damage and remodelling in a streptozotocin-induced diabetic model.May 09, 2019

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Pubmed Data : Phytomedicine. 2014 Sep 15 ;21(10):1208-15. Epub 2014 Jun 2. PMID: 24932975

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2018 Nov 28. Epub 2018 Nov 28. PMID: 30488341

Article Published Date : Nov 27, 2018

Study Type : Animal Study

Additional Links

Substances : Phloretin

Diseases : Alzheimer's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

The present study evidenced strong anti-oxidant and anti-inflammatory effects of phloretin against tissue damage from CLP-induced sepsis.May 05, 2016

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A review of the induced cytoprotective effects of Phloretin on mammalian cells.Dec 31, 2015

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Pubmed Data : Biofactors. 2016 Jan-Feb;42(1):13-40. Epub 2016 Jan 30. PMID: 26826024

Article Published Date : Dec 31, 2015

Study Type : Review

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Substances : Phloretin

Pharmacological Actions : Antioxidants, Cytoprotective

[+]

A systemic review of the pharmacological aspects and potential use of phloretin. Dec 31, 2018

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Pubmed Data : Mini Rev Med Chem. 2019 ;19(13):1060-1067. PMID: 30864525

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Pubmed Data : Eur J Pharmacol. 2015 May 5 ;754:162-72. Epub 2015 Mar 3. PMID: 25746422

Article Published Date : May 04, 2015

Study Type : In Vitro Study

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Substances : Phloretin

Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents

[+]

Phloretin ameliorates succinate-induced liver fibrosis by regulating hepatic stellate cells.Jul 31, 2023

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Pubmed Data : Exp Mol Pathol. 2022 Aug ;127:104814. Epub 2022 Jul 22. PMID: 35878674

Article Published Date : Jul 31, 2022

Study Type : In Vitro Study

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Substances : Phloretin

Diseases : Glioblastoma

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

[+]

Phloretin can enhance the killing effect of γδ T cells on SW-1116 cells.Dec 31, 2012

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Pubmed Data : Int Immunopharmacol. 2013 Jan ;15(1):6-14. Epub 2012 Nov 19. PMID: 23174508

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

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Substances : Phloretin

Diseases : Colon Cancer

Pharmacological Actions : Immunomodulatory

[+]

Phloretin can inhibit BEL-7402 cells' malignant pheotype.Jun 30, 2008

Phloretin has an anti-apoptotic effect on cisplatin-induced apoptosis in HEI-OC1 auditory cells.Dec 31, 2010

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Pubmed Data : Pharmacol Rep. 2011 ;63(3):708-16. PMID: 21857081

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Pubmed Data : Toxicol Int. 2014 May ;21(2):179-85. PMID: 25253928

Article Published Date : Apr 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Oral Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer

[+]

Phloretin in benign prostate hyperplasia and prostate cancer.Jul 10, 2022

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[+]

Phloretin is a promising anti-infective therapeutic for infections caused by L. monocytogenes.Dec 31, 2016

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Pubmed Data : J Cardiovasc Pharmacol. 2015 May ;65(5):444-55. PMID: 25945863

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Atherosclerosis

Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Phloretin may prove beneficial as a promising drug candidate for gastric cancer treatment.Dec 31, 2019

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Pubmed Data : J BUON. 2020 Jan-Feb;25(1):308-313. PMID: 32277647

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Pubmed Data : Mol Nutr Food Res. 2013 Oct ;57(10):1803-13. Epub 2013 Jun 17. PMID: 23776070

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Pubmed Data : Methods. 2007 Aug;42(4):339-48. PMID: 18158826

Article Published Date : Aug 01, 2007

Study Type : In Vitro Study

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Substances : Apples, Pear, Phloretin

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells.Mar 31, 1999

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Pubmed Data : Oncol Lett. 2022 Sep ;24(3):321. Epub 2022 Jul 19. PMID: 35949608

Article Published Date : Aug 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic

[+]

Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin.Jan 31, 2018

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Pubmed Data : Oncol Lett. 2018 Feb ;15(2):1985-1992. Epub 2017 Nov 23. PMID: 29399200

Article Published Date : Jan 31, 2018

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View the Evidence: 137 Abstracts with Phloretin Research

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Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Protective effects of a topical antioxidant mixture against ultraviolet-induced photodamage in human skin.Nov 30, 2008

Antioxidant mixtures could prevent the harmful effects of ozone induced oxidative stress in human keratinocytes.Dec 31, 2014

Phloretin has neuroprotective effects on rotenone-induced toxicity in human SH-SY5Y neuronal-like cells.Jul 07, 2017

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Phloretin might have a potential application in the development of treatment for MRSA infections.Jul 31, 2015

The apple polyphenol phloretin inhibits colorectal cancer cell growth.Sep 13, 2016

The combination of HSP70 with phloretin could be a novel treatment for efficient immunotherapy of intractable cancers such as skin melanoma.Dec 31, 2015

Phloretin alleviates doxorubicin-induced cardiotoxicity.Oct 31, 2023

Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway.Apr 30, 2022

Phloretin mitigates oxidative injury, inflammation and fibrogenic responses.May 20, 2022

Coenzyme Q10, biochanin A, and phloretin counteracted the neurotoxic effect due to Cr(VI) exposure in scavenging of free radicals.Aug 11, 2022

Hepatotoxicity and endothelial dysfunction induced by high choline diet and the protective effects of phloretin in mice.Jul 31, 2016

Interplay between the gut microbiome and metabolism in ulcerative colitis Mice treated with the dietary ingredient phloretin.Oct 27, 2021

Low-dose phloretin alleviates diabetic atherosclerosis through endothelial KLF2 restoration.Dec 02, 2019

Neuroprotective effect of phloretin in rotenone-induced mice model of Parkinson's disease.Nov 25, 2022

Phloretin also acts as an inhibitor of E. coli O157:H7 biofilm formation as well as an anti-inflammatory agent in inflammatory bowel diseases.Nov 30, 2011

Phloretin ameliorates acetic acid induced colitis.Jan 23, 2020

Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.Nov 01, 2019

Phloretin ameliorates diabetic nephropathy by inhibiting nephrin and podocin reduction through a non-hypoglycemic effect.May 26, 2022

Phloretin ameliorates heart function after myocardial infarction.Aug 31, 2023

Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction.Dec 31, 2019

Phloretin ameliorates testosterone-induced benign prostatic hyperplasia.Jul 25, 2021

Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation.Dec 08, 2020

Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance.May 31, 2023

Phloretin attenuates allergic airway inflammation and oxidative stress in asthmatic mice.Dec 31, 2016

Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice.Jun 24, 2019

Phloretin attenuates the inflammatory and oxidative stress pathways that accompany lung injury in mice.Oct 31, 2016

Phloretin attenuation of hepatic steatosis via an improvement of mitochondrial dysfunction.Dec 12, 2021

Phloretin can be used in a potential combination therapy with metformin for the prevention and rescue of type 2 diabetes.Dec 09, 2019

Phloretin could be a potent and effective antiarthritis agent.Dec 31, 2015

Phloretin could be a potential therapeutic treatment for COPD.Dec 11, 2017

Phloretin could be a promising agent in the management of diabetic neuropathy.Apr 30, 2018

Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression.Dec 31, 2022

Phloretin exhibited neuroprotective effects in cerebral ischemia/reperfusion.Apr 14, 2015

Phloretin has nootropic, neuroprotective and neurotrophic activities in scopolamine induced memory impaired mice.Jul 31, 2015

Phloretin has potential as a dietary supplement targeting key therapeutic mechanisms in neurodegenerative disorders.Apr 22, 2018

Phloretin has the potential to be utilized as an alternative therapeutic agent for treating atopic dermatitis.Dec 31, 2019

Phloretin improved glucose and lipid metabolism in rats with STZ-induced diabetes.Dec 31, 2016

Phloretin inhibited the pathogenicity and virulence factors against Candida albicans.Nov 30, 2021

Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.Feb 29, 2012

Phloretin is able to inhibit NSCLC A549 cell growth by inducing apoptosis.Nov 30, 2015

Phloretin may be a potent reagent for hepatocellular carcinoma treatment. Oct 15, 2019

Phloretin may be a potential agent for the treatment of osteoarthritis.Nov 22, 2017

Phloretin might be a promising therapy for hyperuricemia‐related cardiovascular diseases.Sep 30, 2017

Phloretin might be able to increase insulin sensitivity and alleviate the metabolic diseases.Nov 30, 2014

Phloretin protects against cardiac damage and remodelling in a streptozotocin-induced diabetic model.May 09, 2019

Phloretin suppresses intestinal inflammation and maintained epithelial tight junction integrity by modulating cytokines secretion in in vitro model of gut inflammation.Dec 31, 2022

Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages.Jul 03, 2021

Phloretin was effective in preventing estrogen deficiency-induced osteoclastogenic resorption.Sep 14, 2014

Selected dietary components alone or in combination with other therapeutic approaches could prevent diabetes-related complications.Nov 30, 2016

The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation.Dec 31, 2017

The modulatory role of phloretin in Aβ25-35 induced sporadic Alzheimer's disease in rat model.Nov 27, 2018

The present study evidenced strong anti-oxidant and anti-inflammatory effects of phloretin against tissue damage from CLP-induced sepsis.May 05, 2016

The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice.Jan 02, 2019

Therapeutic effects of biochanin A, phloretin, and epigallocatechin-3-gallate in reducing oxidative stress in arsenic-intoxicated mice.Jan 05, 2021

Therapeutic effects of coenzymeQ10, biochanin A and phloretin against arsenic and chromium induced oxidative stress.Apr 30, 2022

These results provide direct evidence to support a possible use of phloretin for mitigation of obesity and maintenance of metabolic homeostasis.Feb 13, 2017

3-OH phloretin inhibits high-fat diet-induced obesity and obesity-induced inflammation.Feb 14, 2023

A review of the induced cytoprotective effects of Phloretin on mammalian cells.Dec 31, 2015

A systemic review of the pharmacological aspects and potential use of phloretin. Dec 31, 2018

An overview of natural plant products in the treatment of hepatocellular carcinoma.Jun 02, 2018

Antimicrobial and anti-Inflammatory activity of apple polyphenol phloretin on respiratory pathogens.Dec 31, 2020

Antimicrobial susceptibility of Staphylococcus aureus strains and effect of phloretin on biofilm formation.Jul 25, 2023

Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment.Dec 08, 2021

Biochemical and antimicrobial activity of phloretin.Sep 30, 2014

Comparison of antioxidant capacity and network pharmacology of phloretin and phlorizin against neuroinflammation in traumatic brain injury.Jan 16, 2023

Flavonoid phloretin inhibits adipogenesis and increases OPG expression in adipocytes derived from human bone-marrow mesenchymal stromal-cells.Nov 21, 2021

In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis.Sep 30, 2020

Inhibition of biofilm formation and virulence factors of cariogenic oral pathogen Streptococcus mutans by natural flavonoid phloretin.Dec 31, 2022

Metabolomics insights of the immunomodulatory activities of phlorizin and phloretin on human THP-1 macrophages.Feb 02, 2021

Phloretin (Ph), a natural product found in apples and pears, inhibits liver cancer cells. May 01, 2009

Phloretin

View the Evidence:
137 Abstracts with Phloretin Research