Phycocyanin

Name	AC	CK
Oxidative Stress	39	57
Inflammation	23	36
Lipid Peroxidation	9	12
Chemotherapy-Induced Toxicity: Cisplatin	5	10
Chronic Pain	1	10
Colitis	5	10
Lipopolysaccharide-Induced Toxicity	6	10
Menstrual Migraine	1	10
Alzheimer's Disease	7	9
Colon Cancer	4	9
Parkinson's Disease	6	8
Wound Healing	6	8
Breast Cancer	4	7
Diabetes Mellitus: Type 2	4	7
Obesity	4	7
Cancers: All	5	6
Carcinoma: Non-Small-Cell Lung	6	6
Cataract	3	6
Infertility: Female	3	6
Lung Cancer	6	6
Ovarian Cancer	2	6
Allergies	3	5
Brain Ischemia	3	5
Chemotherapy-Induced Kidney Damage	2	5
Melanoma	4	5
Multiple Sclerosis	3	5
Myocardial Infarction	2	5
Radiation	3	5
Skin Cancer	3	5
Chemically-Induced Liver Damage	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Endotoxemia	2	4
Liver Cancer	4	4
Liver Injury: Ischemia/reperfusion	2	4
Advanced Glycation End products (AGE)	2	3
Aging	2	3
Brain Cancer	1	3
Cancers: Drug Resistant	3	3
Endometrial Cancer	1	3
Hyperoxaluria	2	3
Mitochondrial Dysfunction	3	3
Neurodegenerative Diseases	3	3
Non-Small-Cell Lung Carcinoma	1	3
Nonalcoholic fatty liver disease (NAFLD)	1	3
Pancreatic Cancer	2	3
Pulmonary Fibrosis	2	3
Ultraviolet Radiation Induced Damage	2	3
Anxiety	1	2
Asthma	1	2
Brain: Microglial Activation	1	2
Breast Cancer: Triple Negative	2	2
Cancer Metastasis	1	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chronic Kidney Disease (CKD)	1	2
Colorectal Cancer	1	2
Cryptosporidiosis	1	2
Cystitis	1	2
Depression	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Complications	2	2
Diabetic Nephropathy	1	2
Diabetic Retinopathy	1	2
Diabetic Ulcer	1	2
Endothelial Dysfunction	1	2
Esophageal Cancer	1	2
Gram-Negative Bacterial Infections	1	2
Gram-Positive Bacterial Infections	1	2
Heart Disease	1	2
High Fat Diet	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hypertension	1	2
IgE-Mediated Hypersensitivity	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Liver Damage	1	2
Myocardial Ischemia	1	2
Osteoarthritis	2	2
Ovarian hyperstimulation syndrome (OHSS)	1	2
Polycystic Ovary Syndrome	1	2
Pre-Eclampsia	1	2
Prostate Cancer	2	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Staphylococcus aureus infection	2	2
Tinnitus	1	2
Uranium Poisoning	1	2
Alcohol Toxicity	1	1
Arthritis	1	1
Aspirin-Induced Toxicity	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Albicans	1	1
Chronic Myeloid Leukemia	1	1
Copper Toxicity	1	1
Coronavirus Disease (Covid-19)	1	1
Diabetes: Cognitive Dysfunction	1	1
Endometritis	1	1
Gastric Cancer	1	1
Gastric Ulcer	1	1
Glioblastoma	1	1
HIV	1	1
Helicobacter Pylori Infection	1	1
Hyperalgesia	1	1
Iron Overload	1	1
Kidney Damage	1	1
Kidney Diseases	1	1
Leukemia	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Metabolic Syndrome X	1	1
Oral Cancer	1	1
Pseudomonas aeruginosa	1	1
Salmonella Infections	1	1
Squamous cell carcinoma	1	1
Steptococcus Mutans Infections	1	1
Urolithiasis	1	1

Name	AC	CK
Antioxidants	64	99
Anti-Inflammatory Agents	51	81
Apoptotic	29	39
Antiproliferative	28	34
Neuroprotective Agents	20	30
Tumor Necrosis Factor (TNF) Alpha Inhibitor	18	27
Anti-Apoptotic	16	24
Cyclooxygenase 2 Inhibitors	12	19
Hepatoprotective	5	18
Interleukin-6 Downregulation	11	18
Antineoplastic Agents	13	17
Chemoprotective Agents	8	16
Malondialdehyde Down-regulation	8	16
NF-kappaB Inhibitor	10	14
Nrf2 activation	9	14
Superoxide Dismutase Up-regulation	7	14
Anti-metastatic	9	13
Renoprotective	7	13
Prophylactic Agents	2	12
Analgesics	2	11
Cardioprotective	5	11
Cell cycle arrest	7	11
Anticoagulants	1	10
Heme oxygenase-1 up-regulation	6	9
Anti-Bacterial Agents	5	6
Fertility Agents: Female	3	6
Gastrointestinal Agents	3	6
Immunomodulatory	4	6
Interferon Gamma Reducer	3	6
Tumor Suppressor Protein p53 Upregulation	3	6
Bcl-2 protein down-regulation	4	5
Hypoglycemic Agents	3	5
Interleukin-1 beta downregulation	3	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	5
Postaglandin PGE2 downregulation	3	5
Radioprotective	3	5
Anti-Allergic Agents	2	3
Autophagy Inhibitors	3	3
Chemotherapeutic	1	3
Cyclin D1 Down-Regulation	3	3
Interleukin-10 upregulation	2	3
Radiosensitizer	1	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Anti-Fibrotic	1	2
Anti-Glycation Agents	1	2
Anticarcinogenic Agents	1	2
Antihypertensive Agents	1	2
Catalase Up-Regulation	1	2
Chemopreventive	1	2
Chemosensitizer	2	2
Cyclooxygenase Inhibitors	2	2
Fertility Agents: Male	1	2
Gastroprotective	2	2
Interleukin-17 downregulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	2
Pancreato Protective Agents	1	2
Photoprotective	1	2
interleukin-13 down-regulation	1	2
Angiogenesis Inducing Agents	1	1
Antifungal Agents	1	1
Antimicrobial	1	1
Antiviral Agents	1	1
Chondroprotective	1	1
Enzyme Inhibitors	1	1
Interleukin-10 downregulation	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
Nitric Oxide Inhibitor	1	1

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Consumption of ACE showed safety regarding markers pertaining to anticoagulant activity and platelet activation status.Jun 30, 2016

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Pubmed Data : J Med Food. 2016 Jul ;19(7):645-53. Epub 2016 Jun 30. PMID: 27362442

Article Published Date : Jun 30, 2016

Study Type : Human Study

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Substances : Phycocyanin

Diseases : Chronic Pain

Pharmacological Actions : Analgesics, Anticoagulants, Hepatoprotective

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Perimenstrual supplementation with phycocyanin and palmitoylethanolamide was associated with reduced severity, duration, and perimenstrual frequency of menstrual migraine attacks.Apr 09, 2026

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Pubmed Data : Free Radic Biol Med. 2025 Sep ;237:160-175. Epub 2025 May 30. PMID: 40451467

Article Published Date : Aug 31, 2025

Study Type : Animal Study, In Vitro Study

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Substances : Phycocyanin

Diseases : Myocardial Infarction, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

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The synergistic activity of betaine and C-PC on A549 cells growth observed in vitro.Dec 31, 2015

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Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway.Jul 18, 2017

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Therapeutic efficacy of natural product 'C-phycocyanin' in alleviating streptozotocin-induced diabetes via the inhibition of glycation reaction.Nov 16, 2022

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Pubmed Data : Int J Mol Sci. 2022 Nov 17 ;23(22). Epub 2022 Nov 17. PMID: 36430714

Article Published Date : Nov 16, 2022

Study Type : Animal Study

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Substances : Phycocyanin

Diseases : Advanced Glycation End products (AGE), Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Glycation Agents, Hypoglycemic Agents

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Therapeutic potential of phycocyanin in attenuating uranium-induced neurophysiological alterations.Mar 31, 2026

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Pubmed Data : J Appl Toxicol. 2026 Apr ;46(4):1207-1221. Epub 2025 Oct 7. PMID: 41057273

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Pubmed Data : Nutrients. 2022 Dec 1 ;14(23). Epub 2022 Dec 1. PMID: 36501143

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Pubmed Data : Eur J Pharmacol. 2010 Dec 15 ;649(1-3):74-83. Epub 2010 Sep 19. PMID: 20858479

C-Phycocyanin-derived phycocyanobilin as a potential nutraceutical approach for major neurodegenerative disorders and COVID-19- induced damage.Dec 31, 2020

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Pubmed Data : Biotechnol Appl Biochem. 2006 Mar ;43(Pt 3):155-64. PMID: 16316316

Article Published Date : Feb 28, 2006

Study Type : In Vitro Study

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Substances : Phycocyanin

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells.Oct 22, 2015

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Pubmed Data : Can J Vet Res. 2015 Jul ;79(3):241-9. PMID: 26130858

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Phycocyanin

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

PHY protects Caco-2 cells, preserving intestinal barrier integrity under oxidative and inflammatory stress, and may serve as a natural therapeutic candidate against obesity-related gut dysfunction.Feb 28, 2026

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Transcriptome analysis of phycocyanin-mediated inhibitory functions on non-small cell lung cancer A549 cell growth.Dec 14, 2018

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Pubmed Data : Mar Drugs. 2018 Dec 15 ;16(12). Epub 2018 Dec 15. PMID: 30558318

Article Published Date : Dec 14, 2018

Study Type : In Vitro Study

Additional Links

Substances : Phycocyanin

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative

Additional Keywords : Gene Expression Regulation

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Unraveling the anti-aging properties of phycocyanin from the Cyanobacterium Spirulina.Apr 10, 2024

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Pubmed Data : Int J Mol Sci. 2024 Apr 11 ;25(8). Epub 2024 Apr 11. PMID: 38673801

Article Published Date : Apr 10, 2024

Study Type : In Vitro Study

Additional Links

Substances : Phycocyanin, Spirulina

Diseases : Aging

Pharmacological Actions : Antioxidants

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View the Evidence: 164 Abstracts with Phycocyanin Research

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Consumption of ACE showed safety regarding markers pertaining to anticoagulant activity and platelet activation status.Jun 30, 2016

Perimenstrual supplementation with phycocyanin and palmitoylethanolamide was associated with reduced severity, duration, and perimenstrual frequency of menstrual migraine attacks.Apr 09, 2026

Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells.Sep 25, 2015

Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin.Dec 31, 2009

C-phycocyanin attenuates cisplatin-induced nephrotoxicity in mice.Dec 31, 2011

C-phycocyanin: a natural product with radiosensitizing property for enhancement of colon cancer radiation therapy efficacy.Dec 15, 2019

Packaging cordycepin phycocyanin micelles for the inhibition of brain cancer.Aug 13, 2017

Phycocyanin liposomes for topical anti-inflammatory activity: in-vitro in-vivo studies.Mar 31, 2009

Potential use of C-phycocyanin in non-alcoholic fatty liver disease.Jun 10, 2020

Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer.Jul 31, 2022

The peptide from C- Phycocyanin alleviates myocardial ischemia-reperfusion injury by suppressing ferroptosis via upregulating UCHL3.Aug 31, 2025

The synergistic activity of betaine and C-PC on A549 cells growth observed in vitro.Dec 31, 2015

Ameliorative effects of phycocyanin against gibberellic acid induced hepatotoxicity.Feb 28, 2015

Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats.Dec 31, 1998

Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae.Dec 31, 1997

Beneficial effects of oral administration of C-Phycocyanin and Phycocyanobilin in rodent models of experimental autoimmune encephalomyelitis.Jan 31, 2018

Bioactive C-phycocyanin exerts immunomodulatory and antitumor activity in mice with induced melanoma.Feb 29, 2024

Biomimetic phycocyanin lipid-based nanoparticles ameliorate placental dysfunction and restore angiogenic balance in a pre-eclampsia model.May 06, 2026

C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota-metabolites axis in mice.Dec 31, 2021

C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes.Dec 31, 2005

C-Phycocyanin ameliorates mitochondrial fission and fusion dynamics in ischemic cardiomyocyte damage.Dec 31, 2018

C-Phycocyanin ameliorates ovarian hyperstimulation syndrome by mitigating inflammation and enhances fertility in an OHSS mouse model.Feb 25, 2026

C-Phycocyanin elicited antitumor efficacy via cell-cycle arrest, apoptosis induction, and invasion inhibition in esophageal squamous cell carcinoma.Mar 31, 2019

C-phycocyanin extract modulates thermogenic and inflammatory markers in brown adipose tissue of high-fat diet-fed animals.Jun 09, 2025

C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury.Aug 09, 2011

C-phycocyanin mitigates cognitive impairment in doxorubicin-induced chemobrain.Jan 31, 2021

C-phycocyanin modulates selenite-induced cataractogenesis in rats.Dec 31, 2012

C-phycocyanin partially rescued female reproductive capability which was impaired by D-galactose in mice.Mar 16, 2016

C-Phycocyanin prevents acute myocardial infarction-induced oxidative stress, inflammation and cardiac damage.Nov 30, 2022

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress.Jul 31, 2015

C-phycocyanin prevents cisplatin-induced nephrotoxicity through inhibition of oxidative stress.Feb 28, 2014

C-phycocyanin prevents oxidative stress, inflammation, and lung remodeling in an ovalbumin-induced rat asthma.Jun 26, 2024

C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling.Apr 30, 2006

C-phycocyanin protects against obesity-associated type 2 diabetes-induced male fertility dysfunction.Feb 23, 2026

C-phycocyanin relieved symptoms associated with cyclophosphamide-induced cystitis.Dec 31, 2018

Comparative neuroregenerative effects of C-phycocyanin and IFN-beta in a model of Multiple sclerosis.Feb 29, 2016

E@PPH could be an enhancing micelle for delivering therapeutic proteins and promoting protein functional recovery, particularly in addressing the challenges posed by tumor heterogeneity in breast cancer.Nov 10, 2024

Effects of C-phycocyanin and Spirulina on salicylate-induced tinnitus, expression of NMDA receptor and inflammatory genes.Dec 31, 2012

Effects of C-Phycocyanin on the representative genes of tumor development in mouse skin exposed to 12-O-tetradecanoyl-phorbol-13-acetate.Oct 31, 2012

Effects of phycocyanin extract on prostaglandin E2 levels in mouse ear inflammation test.Nov 30, 2000

Effects of phycocyanin extract on tumor necrosis factor-alpha and nitrite levels in serum of mice treated with endotoxin.Aug 31, 2001

Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model.Nov 30, 2020

Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation.Jul 31, 1998

Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty.Aug 18, 1998

Mitigating PCOS progression: The protective effect of C-phycocyanin on ovarian granulosa cell pyroptosis.Jun 25, 2025

Multi-omics analysis reveals the attenuation effect of C-phycocyanin on aging-induced subfertility in female mice.Jun 02, 2025

Neuroprotective effects of C-phycocyanin in chronic unpredictable mild stress.Jan 06, 2026

Novel insights into the molecular mechanisms involved in the neuroprotective effects of C-phycocyanin against brain ischemia.Dec 31, 2021

Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway.Oct 31, 2020

Phycocyanin ameliorates alloxan-induced diabetes mellitus.Mar 04, 2016

Phycocyanin ameliorates colitis-associated colorectal cancer.Apr 08, 2022

Phycocyanin ameliorates mouse colitis.Mar 20, 2022

Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress.Jan 14, 2013

Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway.Jul 18, 2017

Phycocyanin enhances secretary IgA antibody response and suppresses allergic IgE antibody response.Mar 31, 2004

Phycocyanin functionalized selenium nanoparticles for type I photodynamic antibacterial therapy and wound healing.Jul 09, 2025

Phycocyanin improves reproductive ability in obese female mice by restoring ovary and oocyte quality.Dec 31, 2019

Phycocyanin inhibits pancreatic cancer metastasis.Oct 13, 2021

Phycocyanin may suppress D-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways.Nov 22, 2012

Phycocyanin/PEG- b-(PG- g-PEI) attenuated hepatic ischemia/reperfusion-induced pancreatic islet injury and enlarged islet functionality.Dec 31, 2018

Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis.Mar 31, 2012

Preventive effect of phycocyanin from Spirulina platensis on alloxan-injured mice.Oct 31, 2012

Prophylactic role of phycocyanin: a study of oxalate mediated renal cell injury.Aug 09, 2004

Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus.Dec 02, 1999

Protective effects of phycocyanin on ischemia/reperfusion liver injuries.May 31, 2018

Protective role of C-phycocyanin against secondary changes during sodium selenite mediated cataractogenesis.Mar 31, 2014

Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells.Oct 31, 2012

Targeted delivery of phycocyanin for the prevention of colon cancer using electrospun fibers.Apr 16, 2019

Targeting angiogenic pathway for chemoprevention of experimental colon cancer using C-phycocyanin as cyclooxygenase-2 inhibitor.May 31, 2014

The alleviative effect of C-phycocyanin peptides against TNBS-induced inflammatory bowel disease.Jan 31, 2024

The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin.Dec 31, 2022

The antiparasitic effect of C-Phycocyanin nanoparticles on cryptosporidiosis in immunosuppressed mice.Feb 28, 2025

Phycocyanin

View the Evidence:
164 Abstracts with Phycocyanin Research