Phyllanthus niruri (Stonebreaker)

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31 Diseases Researched for Phyllanthus niruri (Stonebreaker)
NameACCKFocus
Osteoarthritis: Knee220Locked
Alcohol Toxicity 110Locked
Hangover110Locked
Pharyngitis110Locked
Tonsillitis110Locked
Lipopolysaccharide-Induced Toxicity46Locked
HIV Infections45Locked
Kidney Stones24Locked
Melanoma24Locked
Prostate Cancer24Locked
Arthritis12Locked
Brain Inflammation 12Locked
Cognitive Decline/Dysfunction12Locked
Dengue12Locked
Lung Cancer12Locked
Melanoma: Metastatic12Locked
Memory Disorders12Locked
Prostate Cancer: Metastatic12Locked
Radiation Induced Illness12Locked
Skin Cancer12Locked
Urolithiasis12Locked
Aluminum Toxicity 11Locked
Asthma11Locked
Cancers: All11Locked
Cervical Cancer11Locked
Infection: Antibiotic Resistant11Locked
Inflammation11Locked
Neuropathic Pain11Locked
Staphylococcus aureus infection11Locked
Virus Infections: Drug Resistant11Locked
Hyperuricemia10Locked
33 Pharmacological Actions Researched for Phyllanthus niruri (Stonebreaker)
NameACCKFocus
Anti-Inflammatory Agents938Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor414Locked
Nitric Oxide Inhibitor212Locked
Immunomodulatory110Locked
Interleukin-10 upregulation110Locked
Interleukin-8 upregulation110Locked
Apoptotic47Locked
Anti-metastatic36Locked
Neuroprotective Agents35Locked
Angiogenesis Inhibitors24Locked
Anti-HIV Agents34Locked
Antiproliferative 24Locked
Interleukin-1 beta downregulation34Locked
Matrix Metalloproteinase-7 (MMP-7) Inhibitor24Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor24Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor24Locked
NF-kappaB Inhibitor34Locked
Antiviral Agents23Locked
Chemopreventive12Locked
HIV Protease Inhibitors12Locked
Radioprotective12Locked
Reverse Transcriptase Inhibitors22Locked
Analgesics11Locked
Anti-Bacterial Agents11Locked
Antimicrobial11Locked
Antinoceceptive 11Locked
Antioxidants11Locked
Cyclooxygenase 2 Inhibitors11Locked
Heme oxygenase-1 up-regulation11Locked
P21 Activation11Locked
Transforming growth factor beta (TGF-β) inhibitor11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
28 Abstracts with Phyllanthus niruri (Stonebreaker) Research

[+]

Beneficial effects of Phyllanthus amarus leaves on hangover symptoms.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):145-153. PMID: 30922154
Article Published Date : Nov 30, 2019
Study Type : Human Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Alcohol Toxicity , Hangover
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-8 upregulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Black cumin (Nigella sativa) and Phyllanthus niruri provide symptomatic relief in the treatment of acute tonsillo-pharyngitis patients.Jun 01, 2008

Pubmed Data : Int J Clin Pharmacol Ther. 2008 Jun;46(6):295-306. PMID: 18541126
Article Published Date : Jun 01, 2008
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Phyllanthus niruri (Stonebreaker)
Diseases : Pharyngitis, Tonsillitis
Additional Keywords : Plant Extracts
[+]

Phonophoresis of Phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis.Dec 31, 2019

Pubmed Data : J Bodyw Mov Ther. 2020 Jan ;24(1):15-18. Epub 2019 May 4. PMID: 31987536
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Significant Treatment Outcome
[+]

Phyllanthus amarus could alleviate knee pain and significantly reduce systemic anti-inflammatory effects in knee osteoarthritis patients.Aug 31, 2019

Pubmed Data : Chin J Integr Med. 2019 Sep ;25(9):691-695. Epub 2019 Oct 24. PMID: 31650487
Article Published Date : Aug 31, 2019
Study Type : Human Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hibiscus sabdariffa and Phyllanthus amaraus inhibit calcium oxalate stone formation in the rats.Nov 13, 2010

Pubmed Data : J Urol. 2010 Nov 13. Epub 2010 Nov 13. PMID: 21075390
Article Published Date : Nov 13, 2010
Study Type : Animal Study
Additional Links
Substances : Hibiscus sabdariffa , Phyllanthus amarus
Diseases : Kidney Stones
[+]

Phyllanthus amarus has radioprotective properties. Jan 01, 2009

Pubmed Data : Ann Oncol. 2009 Jan;20(1):160-5. Epub 2008 Jul 31. PMID: 19461166
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Phyllanthus amarus , Polyphenols
Diseases : Radiation Induced Illness
Pharmacological Actions : Radioprotective
Additional Keywords : Plant Extracts
[+]

Phyllanthus amarus protects against spatial memory impairment induced by lipopolysaccharide in mice.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioinformation. 2019 ;15(8):535-541. Epub 2019 Aug 31. PMID: 31719762
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Phyllanthus niruri (syn. P. amarus) inhibits HIV replication in vitro and in vivo. Nov 01, 2004

Pubmed Data : Antiviral Res. 2004 Nov;64(2):93-102. PMID: 15498604
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Substances : Phyllanthus niruri (Stonebreaker)
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents, HIV Protease Inhibitors
Additional Keywords : Plant Extracts
[+]

Phyllanthus niruri inhibits crystal growth in renal stone formation. Jun 01, 2002

Pubmed Data : BJU Int. 2002 Jun;89(9):829-34. PMID: 12010223
Article Published Date : Jun 01, 2002
Study Type : Animal Study
Additional Links
Substances : Phyllanthus niruri (Stonebreaker)
Diseases : Kidney Stones, Urolithiasis
[+]

Protective effects of Phyllanthus amarus against lipopolysaccharide-induced neuroinflammation and cognitive impairment.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:632. Epub 2019 Jun 4. PMID: 31231221
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Brain Inflammation , Cognitive Decline/Dysfunction, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Suppressive effects of the standardized extract of Phyllanthus amarus on type II collagen-induced rheumatoid arthritis.Dec 31, 2017

Pubmed Data : Curr Pharm Biotechnol. 2018 ;19(14):1156-1169. PMID: 30539691
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

A review of medicinal herbs in the treatment of neuropathic pain.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2018 Apr ;21(4):347-358. PMID: 29796216
Article Published Date : Mar 31, 2018
Study Type : Review
Additional Links
Substances : Acorus calamus, Bitter Apple, Bitter Melon, Ginkgo biloba, Holy Basil, Kratom, Olive, Palash, Phyllanthus amarus , Saffron, Sage, Tarragon, Turmeric
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
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Anti-inflammatory effects of Phyllanthus amarus.Jul 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jul 25 ;18(1):224. Epub 2018 Jul 25. PMID: 30045725
Article Published Date : Jul 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Antimicrobial activity of Phyllanthus amarus and inhibition of the NorA efflux pump of Staphylococcus aureus by Phyllanthin.Apr 30, 2019

Pubmed Data : Microb Pathog. 2019 May ;130:242-246. Epub 2019 Mar 12. PMID: 30876871
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Infection: Antibiotic Resistant, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial
Additional Keywords : Multidrug Resistance
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Effect of Andrographis paniculata and Phyllanthus amarus leaf extracts on selected biochemical indices in Drosophila melanogaster model of neurotoxicity.Jan 02, 2020

Pubmed Data : Drug Chem Toxicol. 2020 Jan 3:1-10. Epub 2020 Jan 3. PMID: 31899970
Article Published Date : Jan 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Aluminum Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum
Adverse Pharmacological Actions : Neurotoxic
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Lignan enriched fraction of Phyllanthus amarus promotes apoptotic cell death in human cervical cancer cells in vitro.Oct 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Oct 18 ;9(1):14950. Epub 2019 Oct 18. PMID: 31628385
Article Published Date : Oct 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma.Jan 31, 2019

Pubmed Data : Immunopharmacol Immunotoxicol. 2019 Feb ;41(1):55-67. Epub 2018 Dec 12. PMID: 30541359
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phyllanthin holds a great promise as a potential anti-inflammatory agent to treat various inflammatory diseases.Sep 19, 2018

Pubmed Data : Phytother Res. 2018 Sep 20. Epub 2018 Sep 20. PMID: 30238535
Article Published Date : Sep 19, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Phyllanthus amarus exerts various anticancer and anti-inflammatory activities.Jan 31, 2020

Pubmed Data : Inflammopharmacology. 2020 Feb ;28(1):1-18. Epub 2019 Dec 2. PMID: 31792765
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Flavonoids, Oleanolic acid, Phyllanthus amarus , Ursolic Acid
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
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Phyllanthus can interfere with multiple signalling cascades involved in tumorigenesis and be used as a potential therapeutic candidate for treatment of cancer.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:609581. Epub 2013 Apr 16. PMID: 23690850
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus , Phyllanthus niruri (Stonebreaker), Phyllanthus urinaria
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive
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Phyllanthus could be potentially developed as an anti-dengue agent.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2013 ;13:192. Epub 2013 Jul 26. PMID: 23889893
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus , Phyllanthus niruri (Stonebreaker), Phyllanthus urinaria
Diseases : Dengue
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
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Phyllanthus inhibits A549 metastasis by suppressing ERK1/2 and hypoxia pathways that led to suppression of various critical proteins for A549 invasion and migration.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2013 ;13:271. Epub 2013 Oct 20. PMID: 24138815
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus , Phyllanthus niruri (Stonebreaker), Phyllanthus urinaria
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix Metalloproteinase-7 (MMP-7) Inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Plant Extracts
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Phyllanthus niruri (syn. P. amarus) inhibit wild-type HIV virus and reverse reverse transcriptase inhibitor-resistant variants. Sep 01, 2004

Pubmed Data : Biol Pharm Bull. 2004 Sep;27(9):1471-5. PMID: 15340243
Article Published Date : Sep 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus niruri (Stonebreaker)
Diseases : HIV Infections, Virus Infections: Drug Resistant
Pharmacological Actions : Anti-HIV Agents, Reverse Transcriptase Inhibitors
Additional Keywords : Plant Extracts
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Phyllanthus niruri contains the compound nirurisde which has anti-HIV activity. Feb 01, 1996

Pubmed Data : J Nat Prod. 1996 Feb;59(2):196-9. PMID: 8991954
Article Published Date : Feb 01, 1996
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus niruri (Stonebreaker)
Diseases : HIV Infections
Pharmacological Actions : Antiviral Agents, Reverse Transcriptase Inhibitors
Additional Keywords : Plant Extracts
[+]

Phyllanthus niruri inhibits HIV replication. Sep 01, 2003

Pubmed Data : Indian J Med Sci. 2003 Sep;57(9):387-93. PMID: 14515028
Article Published Date : Sep 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus niruri (Stonebreaker)
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
Additional Keywords : Plant Extracts
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Phyllanthus plant has the potential to inhibit tumour metastasis and angiogenesis through the suppression of MMP enzymes.May 20, 2015

Pubmed Data : Nutr Cancer. 2015 May 21:1-13. Epub 2015 May 21. PMID: 25996262
Article Published Date : May 20, 2015
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus , Phyllanthus niruri (Stonebreaker), Phyllanthus urinaria
Diseases : Melanoma, Melanoma: Metastatic, Prostate Cancer, Prostate Cancer: Metastatic
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix Metalloproteinase-7 (MMP-7) Inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Dose Response, Plant Extracts
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This study revealed a comprehensive perspective of the possible mechanism behind the anti-cancer activity of Phyllanthus extracts.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2014 ;11(6):564-77. Epub 2014 Apr 7. PMID: 24782645
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus , Phyllanthus niruri (Stonebreaker), Phyllanthus urinaria
Diseases : Melanoma, Skin Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Phyllanthus niruri has an antihyperuricemic effect. May 03, 2009

Pubmed Data : J Ethnopharmacol. 2009 May 3. PMID: 19397979
Article Published Date : May 03, 2009
Additional Links
Substances : Phyllanthus niruri (Stonebreaker)
Diseases : Hyperuricemia

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