phytoestrogens

Name	AC	CK
Breast Cancer	35	79
Prostate Cancer	21	72
Postmenopausal Disorders	9	67
Osteoporosis	12	62
Osteopenia	7	46
Insulin Resistance	7	42
Hot Flash	5	41
Prostate Cancer: Prevention	2	40
Ovarian Cancer	8	30
Obesity	12	27
Endothelial Dysfunction	4	26
Menopausal Syndrome	6	26
Cancers: Drug Resistant	6	25
Endometrial Cancer	4	22
Fibroids: Uterine	3	22
Asthma	3	21
Cholesterol: Oxidation	2	21
Alzheimer's Disease	15	20
Cardiac Mortality	1	20
Coronary Artery Disease	1	20
Hemodialysis	1	20
Postmenopausal Complications	1	20
Fatty Liver	4	18
Hypothyroidism	3	18
Breast Cancer: Prevention	3	15
Nonalcoholic fatty liver disease (NAFLD)	4	15
Aging	3	14
Diabetes Mellitus: Type 2	3	14
Estrogen Dominance	5	14
Liver Cancer	13	14
Pancreatic Cancer	12	14
Aging Skin	3	13
Cancers: All	13	13
Colon Cancer	7	13
Cardiovascular Diseases	3	12
Endotoxemia	2	12
Infertility: Female	2	12
Hepatic Steatosis	2	11
Bladder Cancer	5	10
Breast Cancer: Triple Negative	5	10
Chemotherapy Induced Myelotoxicity	1	10
Chronic Obstructive Pulmonary Disease	1	10
Cognitive Decline/Dysfunction	5	10
Diabetic Complications	6	10
Hyperlipidemia	1	10
Liver: Fatty	1	10
Lower Urinary Tract Symptoms	1	10
Mastalgia	1	10
Memory Loss	1	10
Premenstrual syndrome	1	10
Prostate: PSA Doubling	1	10
Prostatic Hyperplasia: Benign	1	10
Brain Inflammation	5	9
Cervical Cancer	8	9
Neurodegenerative Diseases	6	9
High Fat Diet	4	8
Lipopolysaccharide-Induced Toxicity	6	8
Oxidative Stress	7	8
Cystic Fibrosis	7	7
Ischemia	4	7
Low Testosterone	2	7
Lung Cancer	7	7
Hyperglycemia	3	6
Hypertension	3	6
Metabolic Syndrome X	2	6
Parkinson's Disease	4	6
Radiation Induced Illness	3	6
Cancer Metastasis	4	5
Diabetes Mellitus: Type 1	3	5
Glioblastoma	4	5
Hyperpigmentation	1	5
Inflammation	4	5
Stroke	2	5
Amyotrophic Lateral Sclerosis	1	4
Autoimmune Diseases	2	4
Bone Fractures	2	4
Breast Cancer: Chemically-Induced	2	4
Cerebral Ischemia	2	4
Chemically-Induced Liver Damage	2	4
Choriocarcinoma	3	4
Coronavirus Infection	3	4
Corticosteroid-Induced Toxicity	2	4
High Cholesterol	1	4
Incontinence: Urinary	1	4
Lupus Erythematosus: Systemic	2	4
Melanoma	4	4
Memory Impairment: Hormone Deficiency Induced	2	4
Prostatitis: Acute	1	4
Prostatitis: Chronic	1	4
Pulmonary Hypertension	2	4
Seizures	2	4
Stroke: Attenuation/Recovery	1	4
Advanced Glycation End products (AGE)	2	3
Arenaviral Hemorrhagic Fever	2	3
Atherosclerosis	2	3
Bisphenol-A Toxicity	2	3
Cancers: Multi-Drug Resistant	2	3
Chemotherapy-Induced Toxicity: Cisplatin	3	3
Chemotherapy-Induced Toxicity: Doxorubicin	2	3
Depression	2	3
Human Papillomavirus (HPV)	2	3
Hypoxia	2	3
Kidney Cancer	2	3
Liver Cancer: Metastatic	2	3
Lymphoma	3	3
Mucopolysaccharidoses	2	3
Multiple Sclerosis	2	3
Osteoarthritis	2	3
Pituitary Tumours	2	3
Rheumatoid Arthritis	2	3
Spinal Cord Injuries	2	3
Squamous cell carcinoma	2	3
Wound Healing	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Alcohol Toxicity	1	2
Amyotrophic lateral sclerosis (ALS)	1	2
Androgen Deficiency	1	2
Aneurysm: Aortic	1	2
B-cell prolymphocytic leukemia (B-PLL)	1	2
BRCA1/BRCA2: Prevalence	1	2
Brain Edema	1	2
Burns	1	2
Cancer Stem Cells	2	2
Colon Cancer: Prevention	1	2
Colorectal Cancer	1	2
Coronavirus Disease	1	2
Cortisol: High	1	2
Cortisone Toxicity	1	2
DNA damage	2	2
Diabetes	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Eye Disease	1	2
Diabetic Neuropathies	1	2
Diabetic Retinopathy	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Encephalomyelitis	1	2
Endometriosis	2	2
Esophageal Cancer	1	2
Gastrointestinal Inflammation	1	2
Glioma	2	2
HIV Infections	2	2
Heart Failure	1	2
Hemorrhagic Fevers: Viral	1	2
Infertility: Aging Associated	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Kidney Damage	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leiomyoma	2	2
Leukemia: B-Cell	1	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	2
Liver Damage	1	2
Liver Damage: Drug-Induced	1	2
Liver Disease	1	2
Liver Fibrosis	1	2
Low DHEA	1	2
Malaria	1	2
Myocardial Infarction	1	2
Neuroblastoma	2	2
Nicotine/Tobacco Toxicity	1	2
Obsessive-Compulsive Disorder	1	2
Osteonecrosis	1	2
Osteoporosis: Male	1	2
Osteoporosis: Steroid-Induced	1	2
Osteosarcoma	2	2
Ovariectomy Associated Adverse Changes	1	2
Overactive Bladder	1	2
Phthalate Toxicity	1	2
Polycystic Ovary Syndrome	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Radiation Induced Illness: Thoracic	1	2
Right Ventricular Hypertrophy	1	2
Sanfilippo Syndrome	1	2
Schistosomiasis	1	2
Sciatica	1	2
Septic Shock	1	2
Shock: Septic	1	2
Skin Cancer	2	2
Sleep Disorders	1	2
Steroid-Induced Toxicity	1	2
Stroke: Ischemic	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thyroid Cancer	2	2
Traumatic Brain Injury	1	2
Urinary Tract Cancer	1	2
Abdominal Obesity (Midsection Fat)	1	1
Adenoviridae Infections	1	1
Aluminum Toxicity	1	1
Anxiety	1	1
Aortic Stenosis	1	1
Arteriosclerosis	1	1
Asthma: Bronchial	1	1
Benzene Toxicity	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Brain Cancer	1	1
Brain: Microglial Activation	1	1
Breast Cancer: BRCA1	1	1
Breast Cancer: Estrogen	1	1
Breast Cancer: estrogen receptor alpha-positive	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cytomegalovirus Infections	1	1
Dengue	1	1
Diabetes: Cataract	1	1
Diabetic Nephropathy	1	1
Dialysis: Renal	1	1
Ebola Virus Infections	1	1
Estrogen Deficiency	1	1
Fibroid Tumor	1	1
Fluoride Toxicity	1	1
Gallbladder Cancer	1	1
Glioblastoma Multiforme	1	1
HSV-1	1	1
HSV-2	1	1
Head and Neck Cancer	1	1
Herpes Simplex Virus Type 2	1	1
High Cortisol	1	1
Intestinal Permeability	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leukemia	1	1
Lymphoma: Burkitt	1	1
Mastocytoma	1	1
Multiple Myeloma	1	1
Myocarditis	1	1
Nanoparticle Toxicity: Polystyrene	1	1
Nasopharyngeal Cancer	1	1
Neurological Conditions	1	1
Oligomenorrhea	1	1
Optic Nerve Diseases	1	1
Ovarian Cancer: Estrogen Induced	1	1
Periodontal Diseases	1	1
Pesticide Toxicity	1	1
Prolactin: Low	1	1
Psoriasis	1	1
Radiotherapy	1	1
Retinoblastoma	1	1
Rotavirus Infections	1	1
Salivary Gland Adenoid Cystic Carcinoma.	1	1
Salivary Gland Diseases	1	1
Skin Diseases: Photo-Aging	1	1
Smoking	1	1
Staphylococcal Infections	1	1
Stomach Cancer	1	1
Testicular Cancer	1	1
Testicular Cancer Stem Cells	1	1
Trophoblastic Neoplasms	1	1
Trophoblastic Tumor	1	1
Vascular Calcification	1	1

Name	AC	CK
Antioxidants	39	111
Apoptotic	67	105
Anti-Inflammatory Agents	38	78
Antiproliferative	59	75
Chemopreventive	22	66
Neuroprotective Agents	35	60
Antineoplastic Agents	15	54
Tumor Necrosis Factor (TNF) Alpha Inhibitor	13	54
NF-kappaB Inhibitor	20	46
Cell cycle arrest	23	39
Anticarcinogenic Agents	14	38
Hypoglycemic Agents	6	38
Interleukin-6 Downregulation	11	25
Chemosensitizer	15	22
Malondialdehyde Down-regulation	2	20
Anti-Apoptotic	11	19
Enzyme Inhibitors	6	17
Chemotherapeutic	11	16
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	16
Anticholesteremic Agents	3	15
Immunomodulatory	9	15
Insulin-Like Growth Factor Inhibition/Downregulation	3	15
Hepatoprotective	8	14
MicroRNA modulator	10	13
Cardioprotective	7	12
Gastrointestinal Agents	2	12
Insulin Sensitizers	2	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	12
Vasodilator Agents	2	12
Anti-metastatic	9	11
Antiviral Agents	9	11
Mitogen-activated protein kinase kinase 4 (MEK4)	1	10
Vascular Cell Adhesion Molecule-1 Inhibitor	1	10
Angiogenesis Inhibitors	6	9
Nrf2 activation	5	8
Cyclooxygenase 2 Inhibitors	5	7
Secretagogue	2	7
Anti-Angiogenic	2	6
Gastroprotective	3	6
Interleukin-1 beta downregulation	3	6
Radiosensitizer	6	6
Steroidogenesis	1	6
Histone deacetylase inhibitor	4	5
Pancreato Protective Agents	3	5
Radioprotective	3	5
Chemoprotective Agents	3	4
Interleukin-8 downregulation	3	4
Nitric Oxide Enhancer	2	4
Vascular Endothelial Growth Factor A Inhibitor	3	4
Vascular Endothelial Growth Factor Inhibitors	3	4
Anti-Adipogenic	3	3
Anti-Anxiety Agents	2	3
Anti-Fibrotic	2	3
Anti-Glycation Agents	2	3
Aromatase Inhibitors	3	3
Cyclin D1 Down-Regulation	3	3
Heme oxygenase-1 up-regulation	2	3
Hypolipidemic	2	3
Osteoprotective	2	3
Renoprotective	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
Antidepressive Agents	1	2
Cell Differentiation Inducer	2	2
Cytoprotective	1	2
Estradiol 3-glucuronide enhancer	2	2
Estrogen Receptor Modulators	2	2
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	2
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation	1	2
Heme oxygenase-1 inducer	1	2
Hypotensive	1	2
Insulinotrophic	1	2
Interleukin-10 downregulation	1	2
Interleukin-10 upregulation	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Neocardiogenic	1	2
P21 Activation	2	2
Prophylactic Agents	1	2
Protein Kinase Inhibitors	1	2
Regenerative	1	2
SIRT1 Activator	1	2
STAT3 Inhibitor	1	2
Spermatogenic	1	2
Stearoyl coenzyme A desaturase-1 modulator	1	2
Superoxide Dismutase Up-regulation	1	2
Anti-Bacterial Agents	1	1
Antimutagenic Agents	1	1
Arginase 1 (Arg1) up-regulation	1	1
Bax/Bcl2 ratio: Increase	1	1
Bcl-2 protein down-regulation	1	1
Bcl-xL down-regulation	1	1
Cytotoxicity	1	1
Drug synergy	1	1
Emmenagogue	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Estrogen Receptor Agonist	1	1
Glucose transporter-1 (GLUT1) expression down-regulation	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Interleukin-23 Downregulation	1	1
Neuritogenic	1	1
Phase II Detoxification Enzyme Inducer	1	1
Postaglandin PGE2 downregulation	1	1
Proteasome Inhibitors	1	1
Secretagogues: Prolactin Up-Regulation	1	1
Tyrosinase inhibitors	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin pathway down-regulation	1	1
Wnt/β-catenin signaling pathway modulation	1	1
apoptosis	1	1

[+]

Exposure to isoflavone-containing soy products may improve endothelial function. Aug 14, 2010

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Aug 14. Epub 2010 Aug 14. PMID: 20709515

Article Published Date : Aug 14, 2010

Study Type : Meta Analysis

Additional Links

Substances : Isoflavones, phytoestrogens, Soy, Soy Protein

Diseases : Cardiac Mortality , Coronary Artery Disease, Endothelial Dysfunction

[+]

Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women.Feb 28, 2017

Click here to read the entire abstract

Pubmed Data : Maturitas. 2017 Mar ;97:44-52. Epub 2016 Dec 28. PMID: 28159061

Article Published Date : Feb 28, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2023 Jul ;163:114821. Epub 2023 May 9. PMID: 37167726

Pubmed Data : J Gastroenterol Hepatol. 2007 Nov;22(11):2009-14. PMID: 17914984

[+]

Soy extract appears to rejuvenate the structure of mature skin.Nov 01, 2004

Click here to read the entire abstract

Pubmed Data : J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):487-92. PMID: 15623355

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2003;47(2):111-7. PMID: 15087261

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones, Soy

Diseases : Prostate Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Soy phytoestrogen has a positive effect on bone turnover indicators in menopausal women with osteopenia. Dec 01, 1999

Click here to read the entire abstract

Pubmed Data : Hum Cell. 1999 Dec;12(4):189-96. PMID: 16255781

Click here to read the entire abstract

Pubmed Data : J Med Food. 2006;9(3):368-72. PMID: 17004900

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones, Soy Protein

Diseases : Cholesterol: Oxidation, Hemodialysis

Pharmacological Actions : Antioxidants

[+]

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetol Metab Syndr. 2019 ;11:111. Epub 2019 Dec 19. PMID: 31890045

Article Published Date : Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Invest Dermatol. 2003 May ;120(5):835-41. PMID: 12713590

Article Published Date : May 01, 2003

Study Type : Human Study

Additional Links

Substances : Genistein, NAC (N-acetyl-L-cysteine)

Diseases : Aging

Pharmacological Actions : Antioxidants

[+]

[+]

Click here to read the entire abstract

Pubmed Data : Life Sci. 2018 May 15 ;201:9-16. Epub 2018 Mar 19. PMID: 29567078

Click here to read the entire abstract

Pubmed Data : Vascul Pharmacol. 2008 Jul;49(1):1-5. Epub 2008 Mar 27. PMID: 18468493

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Diabetes: Cardiovascular Illness

Pharmacological Actions : Cardioprotective, Enzyme Inhibitors

[+]

Coffee contains the isoflavones genistein, daidzein and formononetin.Mar 10, 2010

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2010 Mar 10;58(5):3002-7. PMID: 20131840

Article Published Date : Mar 10, 2010

Study Type : Animal Study

Additional Links

Substances : Coffee, Daidzein, Genistein, Isoflavones

Additional Keywords : Substances that are Linked

[+]

Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis.Jul 27, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2022 Jul 28 ;12(1):12950. Epub 2022 Jul 28. PMID: 35902739

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2008 Aug 27. [Epub ahead of print] PMID: 17554580

Article Published Date : Aug 27, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Osteoporosis: Male

[+]

Effects of genistein and exercise training on brain damage induced by a high-fat high-sucrose diet.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:1560435. Epub 2022 May 17. PMID: 35620577

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Reprod Biomed (Yazd). 2016 Feb ;14(2):95-102. PMID: 27200423

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Infertility: Male

Pharmacological Actions : Spermatogenic

Problem Substances : Morphine

[+]

Genistein administration might improve liver damages induced by morphine in mice.Jul 04, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Med J (Engl). 2018 Jul 5 ;131(13):1598-1604. PMID: 29941714

Click here to read the entire abstract

Pubmed Data : Oncotarget. 2017 Sep 22 ;8(37):61385-61392. Epub 2017 May 26. PMID: 28977871

Article Published Date : Sep 21, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Genistein

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, NF-kappaB Inhibitor

[+]

Genistein alleviates high-fat diet-induced obesity.Apr 07, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Apr 8 ;14(8). Epub 2022 Apr 8. PMID: 35458112

Click here to read the entire abstract

Pubmed Data : Neurobiol Learn Mem. 2011 Mar;95(3):270-6. Epub 2010 Dec 7. PMID: 21144907

Article Published Date : Mar 01, 2011

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Alzheimer's Disease, Learning disorders, Memory Impairment: Hormone Deficiency Induced

Pharmacological Actions : Neuroprotective Agents

[+]

Genistein ameliorates non-alcoholic fatty liver disease by targeting the thromboxane A2 pathway.May 30, 2018

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Pubmed Data : J Agric Food Chem. 2018 May 31. Epub 2018 May 31. PMID: 29771124

Click here to read the entire abstract

Pubmed Data : Neurotox Res. 2020 Jul 1. Epub 2020 Jul 1. PMID: 32613603

Article Published Date : Jun 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Genistein

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Genistein and moderate intensity exercise were effective in reducing the severity of NASH.May 31, 2020

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Pubmed Data : BMC Complement Med Ther. 2020 Jun 1 ;20(1):162. Epub 2020 Jun 1. PMID: 32482167

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Eur J Pharmacol. 2010 Dec 15;649(1-3):242-8. Epub 2010 Sep 18. PMID: 20854807

Article Published Date : Dec 15, 2010

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Pulmonary Hypertension

Pharmacological Actions : Nitric Oxide Enhancer

[+]

Genistein attenuates renal ischemia-reperfusion injury.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Hum Exp Toxicol. 2023 ;42:9603271231164913. PMID: 36932924

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Ischemia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

[+]

Genistein diet improves body weight, serum glucose and triglyceride levels.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:2011-2021. Epub 2019 Oct 3. PMID: 31686880

Pubmed Data : Urology. 2004 Aug;64(2):389-93. PMID: 15302513

Article Published Date : Aug 01, 2004

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Kidney Cancer

[+]

Genistein Inhibits Clostridioides difficile Infection.Mar 27, 2023

Click here to read the entire abstract

Pubmed Data : J Infect Dis. 2023 Mar 28 ;227(6):806-819. PMID: 36628948

Article Published Date : Mar 27, 2023

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Clostridium Infections

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

[+]

Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BTG2 and adipor1.Feb 29, 2020

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Pubmed Data : Food Funct. 2020 Mar 1 ;11(3):2418-2426. Epub 2020 Mar 4. PMID: 32129363

Click here to read the entire abstract

Pubmed Data : Shock. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31626039

Article Published Date : Oct 14, 2019

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Burns

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Genistein protects against hyperglycemia and fatty liver disease in diet-induced prediabetes.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Neurotoxicology. 2016 Mar ;53:153-164. Epub 2016 Jan 18. PMID: 26797587

Article Published Date : Feb 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Genistein

Diseases : Lead Poisoning, Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation

Problem Substances : Lead

[+]

Genistein reduces hyperglycemia and pancreatic islet cell loss in a rat model of diabetic pancreatic damage.Feb 01, 2007

Genistein supplementation might be a potential therapeutic line for the management and prevention of diabetes-associated OCD.Mar 20, 2018

Click here to read the entire abstract

Pubmed Data : J Basic Clin Physiol Pharmacol. 2018 Mar 21. Epub 2018 Mar 21. PMID: 29561730

Article Published Date : Mar 20, 2018

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Diabetic Complications, Obsessive-Compulsive Disorder

Pharmacological Actions : Neuroprotective Agents

[+]

Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer.Feb 07, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Isoflavone daidzein regulates immune responses in the B6C3F1 and non-obese diabetic (NOD) mice.May 31, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Jun ;71:277-284. Epub 2019 Mar 28. PMID: 30927738

Article Published Date : May 31, 2019

Study Type : Animal Study

Additional Links

Substances : Daidzein

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Immunomodulatory

[+]

Low dose of genistein alleviates phthalate-induced fetal testis disorder.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:4569268. Epub 2020 May 27. PMID: 32566080

Article Published Date : Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Apr 29 ;14(9). Epub 2022 Apr 29. PMID: 35565830

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:772485. Epub 2022 Jan 14. PMID: 35095491

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Daidzein, Kudzu

Diseases : Stroke

Pharmacological Actions : Neuroprotective Agents

[+]

Nrf2/HO-1 mediated protective activity of genistein against doxorubicin-induced cardiac toxicity.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : J Environ Pathol Toxicol Oncol. 2019 ;38(2):143-152. PMID: 31679277

Click here to read the entire abstract

Pubmed Data : BMC Cancer. 2009;9:334. Epub 2009 Sep 18. PMID: 19765307

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : phytoestrogens

Diseases : Pituitary Tumours

Pharmacological Actions : Antiproliferative

[+]

Phytogestrogens suppress cortisol output and increase androstenedione secretion in porcine adrenocortical cells. Sep 01, 2007

Click here to read the entire abstract

Pubmed Data : Acta Vet Hung. 2007 Sep;55(3):359-67. PMID: 17867463

Article Published Date : Sep 01, 2007

Study Type : Animal Study

Additional Links

Substances : phytoestrogens

Diseases : Cortisol: High

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Pretreatment of ECFCs with genistein prior to transplantation can improve the regenerative potential in ischemic tissues.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(5):e96155. Epub 2014 May 15. PMID: 24830850

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Pubmed Data : Exp Biol Med (Maywood). 2007 May;232(5):674-81. PMID: 17463164

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Pubmed Data : Clin Radiol. 2003 Apr;58(4):301-5. PMID: 15778278

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Pubmed Data : Carcinogenesis. 2007 Jun;28(6):1217-23. Epub 2007 Jan 18. PMID: 17234721

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The isoflavone daidzein reduces food intake, weight gain and reduces fat content in the livers of animals on an obesity-generating diet. May 10, 2011

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Pubmed Data : Br J Pharmacol. 2011 May 10. Epub 2011 May 10. PMID: 21557739

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Pubmed Data : Biochem Cell Biol. 2010 Aug;88(4):737-45. PMID: 20651847

Article Published Date : Aug 01, 2010

Study Type : Animal Study

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Substances : Flavonoids, Genistein, Polyphenols, Resveratrol

Diseases : Aging, Infertility: Aging Associated, Infertility: Female

Additional Keywords : Plant Extracts, Stilbenes

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The regulatory effect of genistein on granulosa cell in ovary of rat with polycystic ovarian syndrome.Aug 29, 2018

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Antiviral activity of four types of bioflavonoid against dengue virus type-2.Dec 27, 2011

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Pubmed Data : Virol J. 2011 Dec 28 ;8:560. Epub 2011 Dec 28. PMID: 22201648

Article Published Date : Dec 27, 2011

Study Type : In Vitro Study

Additional Links

Substances : Bioflavonoids, Citrus naringin, Daidzein, Fisetin, Flavonoids, Quercetin

Diseases : Dengue

Pharmacological Actions : Antiviral Agents

Additional Keywords : Phytotherapy

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Baicalein and daidzein had a synergistic effect estrogenic and neuroprotective activities in alzheimer's disease and enhanced the effects of different flavonoids.Dec 31, 2012

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Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:635694. Epub 2013 Aug 24. PMID: 24058373

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Baicalein, Daidzein, Flavonoids

Diseases : Alzheimer's Disease, Neurological Conditions, Parkinson's Disease

Pharmacological Actions : Estrogen Receptor Agonist, Neuroprotective Agents

Additional Keywords : Bioenhancer, Natural Substance Synergy

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Beneficial role of the phytoestrogen genistein on vascular calcification.Aug 23, 2017

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Pubmed Data : J Nutr Biochem. 2017 Aug 24 ;50:26-37. Epub 2017 Aug 24. PMID: 28968518

Article Published Date : Aug 23, 2017

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Vascular Calcification

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BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.Feb 12, 2006

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Pubmed Data : Biochem Biophys Res Commun. 1997 Apr 28;233(3):692-6. PMID: 9168916

Article Published Date : Apr 28, 1997

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Genistein, Isoflavones

Diseases : Breast Cancer, Pesticide Toxicity

Pharmacological Actions : Antiproliferative

Additional Keywords : Drug-Plant-Vitamin Synergies

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Daidzein and chicory extract arrest the cell cycle via inhibition of cyclin D/CDK4 and cyclin A/CDK2 gene expression in hepatocellular carcinoma.Mar 20, 2022

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, MicroRNA modulator

Additional Keywords : Dietary Concentrations, Plant Extracts

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Dual effects of isoflavonoids from Pueraria lobata roots on estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells.Feb 28, 2019

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Pubmed Data : Bioorg Chem. 2019 Mar ;83:135-144. Epub 2018 Oct 10. PMID: 30352359

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Genistein, Kudzu

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytother Res. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33786876

Article Published Date : Mar 29, 2021

Study Type : Review

Additional Links

Substances : Biochanin A, Diosmin , EGCG (Epigallocatechin gallate), Epicatechin, Flavonoids, Genistein, Hesperidin, Luteolin, Naringenin , Quercetin, Rutin, Silymarin

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Storm

[+]

Flavonoids on diabetic nephropathy: advances and therapeutic opportunities. Aug 06, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Nutr Cancer. 2000;37(1):49-54. PMID: 10965519

Article Published Date : Jan 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Genistein

Diseases : Skin Cancer

Pharmacological Actions : Chemopreventive

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View the Evidence: 484 Abstracts with phytoestrogens Research

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Exposure to isoflavone-containing soy products may improve endothelial function. Aug 14, 2010

Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women.Feb 28, 2017

Beer drinking contributes to higher bone density as a result of the phytoestrogen content (hops) of this alcoholic beverage. Oct 01, 2009

Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users.Sep 01, 2009

Daidzein-rich isoflavone are effective in reducing hot flashes in menopausal women. Apr 24, 2007

Dietary intake of isoflavone is inversely associated with the risk of lower urinary tract symptoms. Dec 01, 2007

Effectiveness of genistein supplementation on metabolic factors and antioxidant Status in postmenopausal women with type 2 diabetes mellitus.Sep 30, 2019

Effects of genistein aglycone in glucocorticoid induced osteoporosis.Jun 30, 2023

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

Genistein and daidzein consumption are associated with a lower risk of prostate cancer. Aug 01, 2009

Genistein and puerarin could inhibit the pathway of NF-kappaB and TNF-alpha in asthma patients.Jan 31, 2010

Genistein appears to have a positive effect on hot flushes without a negative impact on endometrial thickness in early postmenopausal women.Jul 01, 2004

Genistein can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD.May 31, 2017

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.Oct 01, 2002

Genistein has a positive effect on bone metabolism in osteopenic postmenopausal women, without increasing endometrial thickness. Jun 19, 2007

Genistein has favorable effects on some predictors of cardiovascular risk in osteopenic, postmenopausal women.Jan 18, 2010

Genistein has therapeutic value in reducing PSA levels in men with prostate cancer. Feb 01, 2004

Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients.Jun 17, 2022

Genistein inhibits nonalcoholic fatty liver disease.Nov 01, 2007

Genistein is safe and effective in improving bone density without adverse responses in breast density or endometrium thickness in osteopenic, postmenopausal women. Dec 01, 2008

Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression. Aug 19, 2009

Genistein reduces vasomotor symptoms, e.g. hot flush, within postmenopausal women.Jul 01, 2007

Genistein significantly decreases hot flash symptoms in healthy postmenopausal women.Feb 01, 2011

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects. Dec 31, 2019

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer. Mar 21, 2007

Higher concentrations of circulating genistein may reduce the risk of prostate cancer.Jun 02, 2009

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations.Jan 13, 2021

Increased consumption of genistein is associated with better lung function in patients with asthma. Jan 01, 2004

Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.Jul 01, 2008

Isolfavones have therapeutic value in the treatment of cyclical mastalgia. Apr 01, 2002

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.Jul 01, 2009

Phytoestrogens can reverse the deleterius effects of clomiphene citrate and contribute to higher pregnancy rates. Jul 01, 2004

Quercetin and isoflavone intake is associated with a reduced risk for endometrial cancer. Sep 01, 2009

Resveratrol and genistein may be potential drugs candidates for use in the treatment of COPD.Mar 27, 2016

Soy extract appears to rejuvenate the structure of mature skin.Nov 01, 2004

Soy isoflavone consumption reduce symptoms of premenstrual syndrome. May 01, 2005

Soy isoflavones ameliorate the adverse effects of chemotherapy in children.Oct 01, 1996

Soy isoflavones consumed at levels comparable to those in Asian populations may reduce the risk of cancer recurrence in women receiving tamoxifen therapy and moreover, appears not to interfere with tamoxifen efficacy.Nov 01, 2009

Soy isoflavones may benefit some patients with prostate cancer. Jan 01, 2003

Soy phytoestrogen has a positive effect on bone turnover indicators in menopausal women with osteopenia. Dec 01, 1999

Soy phytoestrogens may improve working memory through estrogen-independent mechanisms.Dec 01, 2008

Soy products, fiber, phytoestrogens, vegetable and fruist, and seaweed consumption reduce the risk of endomentrial cancer. Aug 15, 1997

Soy protein reduces cholesterol oxidation in patients on hemodialysis. Jan 01, 2006

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia.Dec 31, 2018

The soy isoflavone genistein does not adversely effect thyroid function in osteopenic, postmenopausal women. Mar 31, 2010

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

This study shows that genistein may have a role in therapeutics to delay the onset of Alzheimer's dementia.Nov 03, 2022

Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo.May 01, 2003

Vaginally administered genistein and hyaluronic acid both improve symptoms of vaginal atrophy in postmenopausal women.May 31, 2011

Biochanin A from red clover inhibits melanogenesis and may be helpful for hyperpigmentation disorders.Jan 01, 2011

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

Genistein attenuates memory impairment in Alzheimer's disease.Aug 02, 2022

Genistein protects against ultraviolet B-induced wrinkling and photoinflammation in in vitro and in vivo models.Feb 23, 2022

Dietary genistein supplementation protects against lipopolysaccharide-induced intestinal injury through altering transcriptomic profile.Jun 30, 2020

Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure.Jul 07, 2020

"Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats."Oct 31, 2012

"Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome."Mar 31, 2006

A soy extract may be more effective than purified genistein in improving tibial trabecular bone quality in ovariectomized mice. Jul 01, 2009

Administration of N- acetylcysteine and genistein have an additive gastroprotective effect in indomethacin induced gastric injury.Jul 15, 2018

Antibacterial and anti-inflammatory effects of genistein in Staphylococcus aureus induced osteomyelitis.Mar 31, 2023

As mono-therapy the natural isoflavone genistein has a powerful therapeutic effect in vivo on A431 and Colo205 tumors.Apr 06, 2016

Biochanin A ameliorates histological changes of renal and cutaneous tissue related to ovariectomy and/or anastrozole treatment.May 15, 2018

Bone strength is improved with genistein treatment in mice with diet-induced obesity.Oct 31, 2019

Chemopreventive and hepatoprotective effects of genistein.Nov 30, 2022

Chronic treatment of diabetic rats with genistein could prevent the abnormal functional changes in vascular reactivity in diabetic rats. Jul 01, 2008

Coffee contains the isoflavones genistein, daidzein and formononetin.Mar 10, 2010

Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis.Jul 27, 2022

Daidzein alleviates doxorubicin-induced heart failure.Sep 21, 2022

Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits.Oct 31, 2017

Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.Jun 30, 2016

Daidzein attenuates urinary bladder dysfunction in streptozotocin-induced diabetes in rats by NOX-4 and RAC-1 inhibition.May 10, 2022

phytoestrogens

View the Evidence:
484 Abstracts with phytoestrogens Research