Piceatannol

Name	AC	CK
Insulin Resistance	3	12
Dry Skin	1	10
Fatigue	1	10
Obesity	7	10
Overweight	1	10
Breast Cancer	8	8
Oxidative Stress	5	7
Cancers: All	5	6
Lipopolysaccharide-Induced Toxicity	4	5
Colon Cancer	4	4
Inflammation	4	4
Liver Damage	2	4
Prostate Cancer	4	4
Colitis	2	3
Endothelial Dysfunction	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Hyperlipidemia	2	3
Liver Cancer	2	3
Parkinson's Disease	2	3
Streptococcus Infections	1	3
Atrial Arrhythmias	1	2
Atrial Fibrillation	1	2
Cancer Metastasis	1	2
Cardiac Hypertrophy	1	2
Cervical Cancer	2	2
Colorectal Cancer	2	2
Diabetes Mellitus: Type 2	1	2
Diabetic Nephropathy	1	2
Endotoxemia	1	2
Inflammatory Bowel Diseases	1	2
Kidney Fibrosis	1	2
Leukemia: Acute myelogenous leukemia (AML)	2	2
Lipid Peroxidation	1	2
Lung Injury: Acute	1	2
Macular Degeneration	2	2
Melanoma	2	2
Nephropathy	1	2
Osteoarthritis	1	2
Pancreatic Cancer	1	2
Promyelocytic leukemia	2	2
Prostatic Hyperplasia: Benign	1	2
Steptococcus Mutans Infections	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Acne	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Aging Skin	1	1
Allergies	1	1
Alzheimer's Disease	1	1
Bladder Cancer	1	1
Bone Diseases	1	1
Brain Cancer	1	1
Brain: Microglial Activation	1	1
Brain: Oxidative Stress	1	1
Burkitt Lymphoma	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cardiomyopathy	1	1
Cardiovascular Diseases	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Chronic Disease	1	1
Diabetic Complications	1	1
Hyperglycemia	1	1
Hypoglycemia	1	1
Leishmaniasis	1	1
Leukemia: Monocytic	1	1
Lung Cancer	1	1
Multiple Myeloma	1	1
Osteoporosis	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1
Periodontal Diseases	1	1
Pseudomonas aeruginosa	1	1
Rheumatoid Arthritis	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Antioxidants	23	40
Anti-Inflammatory Agents	16	31
Apoptotic	20	21
Antiproliferative	14	15
NF-kappaB Inhibitor	10	14
Antihypertensive Agents	2	12
Nrf2 activation	6	9
Interleukin-6 Downregulation	6	8
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	8
Chemopreventive	7	7
Heme oxygenase-1 up-regulation	5	7
Neuroprotective Agents	6	7
Anti-Bacterial Agents	3	6
Anti-metastatic	5	6
Cardioprotective	4	6
Cell cycle arrest	6	6
Anti-Apoptotic	4	4
Antineoplastic Agents	4	4
Cyclooxygenase 2 Inhibitors	3	4
Hepatoprotective	2	4
Hypoglycemic Agents	3	4
Interleukin-1 beta downregulation	2	4
Angiogenesis Inhibitors	2	3
Bcl-2 protein down-regulation	3	3
Anti-Fibrotic	1	2
Anticarcinogenic Agents	2	2
Chemosensitizer	1	2
Chemotherapeutic	1	2
Extracellular Signal-Regulated Kinases Modulator	1	2
Gastrointestinal Agents	1	2
Heme oxygenase-1 inducer	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	2
MicroRNA modulator	2	2
Nitric Oxide Inhibitor	1	2
Photoprotective	2	2
Prostaglandin PGE2 downregulation	1	2
Renoprotective	1	2
STAT3 Inhibitor	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Vasoprotective	1	2
Alpha-glucosidase inhibitor	1	1
Anti-Allergic Agents	1	1
Cytoprotective	1	1
Hypolipidemic	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Interleukin-8 downregulation	1	1
Leishmanicidal	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Osteoprotective	1	1
Vasodilator Agents	1	1
Wnt/β-catenin signaling pathway modulation	1	1

Additional Keywords : Tumor Microenvironment

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Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

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Piceatannol could be used to limit several obesity complications.Aug 31, 2016

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Pubmed Data : J Physiol Biochem. 2016 Sep ;72(3):567-82. Epub 2016 Jan 20. PMID: 26792656

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Substances : Piceatannol

Diseases : Hyperlipidemia, Obesity

Pharmacological Actions : Antioxidants

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Albumin nano-encapsulation of piceatannol enhances its anticancer potential in colon cancer.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2020 01 1 ;12(1). Epub 2020 Jan 1. PMID: 31906321

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Colitis, Colon Cancer

Pharmacological Actions : Chemopreventive, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

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Antidiabetic, antiglycation, and antioxidant activities of ethanolic seed extract of Passiflora edulis and piceatannolJun 23, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Int J Oncol. 2018 Oct ;53(4):1469-1480. Epub 2018 Aug 1. PMID: 30066852

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

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Substances : Piceatannol , Resveratrol

Diseases : Breast Cancer, Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy

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Effects of wine components in inflammatory bowel diseases.Sep 27, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2022 Dec 5 ;23(23). Epub 2022 Dec 5. PMID: 36499677

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Pubmed Data : Biol Pharm Bull. 2013 ;36(5):845-9. PMID: 23649341

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Pubmed Data : Biochem Biophys Res Commun. 2014 Sep 26 ;452(3):775-81. Epub 2014 Sep 8. PMID: 25218158

Article Published Date : Sep 25, 2014

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, MicroRNA modulator

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Piceatannol can enhance the cytotoxic effects of gemcitabine.Dec 31, 2013

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Pubmed Data : Oncol Res. 2014 ;22(4):213-7. PMID: 26351210

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Pubmed Data : Int Immunopharmacol. 2022 Oct ;111:109107. Epub 2022 Aug 3. PMID: 35932616

Article Published Date : Sep 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants

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Piceatannol enhances cisplatin sensitivity in ovarian cancer.Aug 15, 2013

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Pubmed Data : J Biol Chem. 2013 Aug 16 ;288(33):23740-50. Epub 2013 Jul 5. PMID: 23833193

Article Published Date : Aug 15, 2013

Study Type : In Vitro Study

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Substances : Piceatannol

Diseases : Cancers: Drug Resistant, Chemotherapy-Induced Toxicity: Cisplatin, Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation

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Diseases : Obesity

Additional Keywords : Anti-Obesity Agents

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Piceatannol may attenuate the pathologic inflammation triggered by adipose tissues.Dec 31, 2016

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Pubmed Data : Food Sci Nutr. 2017 Jan ;5(1):76-85. Epub 2016 May 16. PMID: 28070318

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Inflammation, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Piceatannol may support conventional chemotherapy of human malignancies.Sep 30, 2008

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Pubmed Data : Int J Oncol. 2008 Oct ;33(4):887-92. PMID: 18813804

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2013 Oct ;32(4):775-84. Epub 2013 Jul 18. PMID: 23877152

Article Published Date : Sep 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Piceatannol suppresses the proliferation and induced apoptosis of osteosarcoma cells.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Antioxidants (Basel). 2020 May 13 ;9(5). Epub 2020 May 13. PMID: 32414040

Article Published Date : May 12, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

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Piceatannol: A natural stilbene for the prevention and treatment of cancer.Jan 07, 2020

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Pubmed Data : Pharmacol Res. 2020 Jan 8 ;153:104635. Epub 2020 Jan 8. PMID: 31926274

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Pubmed Data : Int J Mol Sci. 2021 Sep 30 ;22(19). Epub 2021 Sep 30. PMID: 34638937

Article Published Date : Sep 29, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Apoptotic, Chemotherapeutic

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These results suggested the potential of piceatannol in improving chronic inflammatory condition and insulin sensitivity in obese adipose tissues.Jun 13, 2017

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Pubmed Data : J Agric Food Chem. 2017 Jun 14 ;65(23):4634-4641. Epub 2017 Jun 5. PMID: 28535046

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View the Evidence: 111 Abstracts with Piceatannol Research

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Supplementation with piceatannol can improve metabolic health, including insulin sensitivity, blood pressure and heart rate, in overweight men.Oct 17, 2017

The oral intake of passion fruit seed extract that is rich in piceatannol could improve the moisture of dry skin and reduce fatigue.Dec 31, 2017

Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer.Oct 19, 2022

Piceatannol prevents colon cancer progression.May 25, 2022

Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes.Dec 31, 2021

Acute electrophysiologic effects of the polyphenols resveratrol and piceatannol in rabbit atria.Jun 28, 2018

Antifibrotic mechanism of piceatannol in bleomycin-induced pulmonary fibrosis in mice.Dec 31, 2021

Antioxidants inhibit neuronal toxicity in leucine-rich repeat kinase-2-linked Parkinson's disease. Mar 31, 2016

Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinoma by piceatannol and/or cisplatin: the interplay between nuclear factor (Erythroid Derived 2)-like 2 and redox status.Oct 31, 2022

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis.Oct 21, 2021

Inhibitory effect of piceatannol on Streptococcus suis infection both in vitro and in vivo Dec 31, 2019

Long-term oral administration of piceatannol attenuates colon tumor growth induced by azoxymethane.Oct 07, 2021

Piceatannol alleviate ROS-mediated PC-12 cells damage and mitochondrial dysfunction.Jun 15, 2021

Piceatannol altered the composition of the gut microbiota by increasing Firmicutes and Lactobacillus and decreasing Bacteroidetes.Oct 24, 2016

Piceatannol ameliorates behavioural, biochemical and histological aspects in cisplatin-induced peripheral neuropathy.Aug 12, 2021

Piceatannol attenuates atopic dermatitis by targeting Janus kinase 1.Feb 11, 2022

Piceatannol attenuates testosterone-induced benign prostatic hyperplasia.Dec 31, 2019

Piceatannol could be used to limit several obesity complications.Aug 31, 2016

Piceatannol exerts anti-angiogenic efficiencies by blockage of vascular endothelial growth factor binding to its receptor.Aug 18, 2020

Piceatannol exhibits a potential protective effect against Indo-induced gastric ulcers.Feb 27, 2022

Piceatannol inhibited S. mutans colonization in an in vivo drosophila model and a rat model of dental caries.Jul 30, 2018

Piceatannol is a promising treatment for preventing acute liver failure.Aug 29, 2018

Piceatannol lowers the blood glucose level in diabetic mice.Dec 31, 2014

Piceatannol may be a beneficial therapeutic agent for treating renal fibrosis.Dec 31, 2015

Piceatannol may be a novel therapeutic agent for the prevention of cardiac hypertrophy.May 01, 2014

Piceatannol may be a potential therapeutic agent for osteoarthritis.Nov 14, 2017

Piceatannol may be a useful anticancer natural product.Dec 31, 2011

Piceatannol mediated modulation of oxidative stress and regeneration in the liver of endotoxemic mice.Mar 14, 2019

Piceatannol protects rat neuron cells from oxygen-glucose deprivation reperfusion injury.Nov 24, 2022

Piceatannol provides remarkable renoprotection in diabetes by abrogating oxidative stress and NF-kB activation.Nov 25, 2016

Piceatannol treatment results in significant protection against cadmium-induced testicular dysfunctions.Dec 31, 2018

Potential renoprotective effects of piceatannol in ameliorating the early-stage nephropathy associated with obesity.Aug 31, 2016

Protective effect of piceatannol against acute lung injury.Dec 31, 2018

Protective effect of piceatannol against cerebral ischaemia-reperfusion injury.Jun 30, 2021

Protective effects of piceatannol against selenite-induced cataract and oxidative damage.Dec 31, 2021

Resveratrol and piceatannol inhibit inflammation in a mouse model of colitis. Jan 01, 2009

These data suggest Piceatannol as a potential treatment for vascular disease.Dec 31, 2016

A comprehensive review on the chemotherapeutic potential of piceatannol for cancer treatment, with mechanistic insights.Feb 02, 2016

A review of the pharmacological effects of piceatannol on cardiovascular diseases.Oct 31, 2014

A review of the therapeutic potential of piceatannol in metabolic diseases.Apr 30, 2017

Albumin nano-encapsulation of piceatannol enhances its anticancer potential in colon cancer.Dec 31, 2019

Antidiabetic, antiglycation, and antioxidant activities of ethanolic seed extract of Passiflora edulis and piceatannolJun 23, 2022

Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds.Mar 31, 2008

Augmentation of anti-proliferative, pro-apoptotic and oxidant profiles induced by piceatannol in human breast carcinoma MCF-7 cells using zein nanostructures.Mar 04, 2021

Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy.Dec 31, 2021

Benefits of skin application of piceatannol-A mini review.Oct 19, 2022

Cardiovascular protective effects of polyphenols contained in passion fruit seedsSep 19, 2021

Combined treatment with resveratrol and piceatannol also decreased tumor cell survival.Sep 30, 2018

Effects of wine components in inflammatory bowel diseases.Sep 27, 2021

Induction of apoptosis by piceatannol in human leukemic U937 cells.Mar 31, 2008

Inhibition of tumor progression by oral piceatannol in mouse 4T1 mammary cancer is associated with decreased angiogenesis and macrophage infiltration.Oct 31, 2015

Mechanism of synergy between piceatannol and ciprofloxacin against Staphylococcus aureus.Dec 04, 2022

Piceatannol alleviates inflammation and oxidative stress in diabetic cardiomyopathy.Jul 15, 2019

piceatannol and myricetin synergistically induced apoptosis in HL-60 cells.Nov 30, 2012

piceatannol and passion fruit seed extract containing high amounts of piceatannol are potential anti-photoageing cosmetic ingredients.Dec 31, 2012

Piceatannol and pterostilbene have protective effects against Aβ-induced apoptosis in PC12 cells.Jan 12, 2016

Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells.Jun 30, 2008

Piceatannol attenuates lipopolysaccharide-induced NF-kappaB activation and NF-kappaB-related proinflammatory mediators in BV2 microglia.Nov 30, 2006

Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption.May 31, 2019

Piceatannol can be considered to be a promising anticancer agent for colorectal cancer.Sep 25, 2014

Piceatannol can enhance the cytotoxic effects of gemcitabine.Dec 31, 2013

Piceatannol can upregulate PI3K-Akt-eNOS signaling to protect cardiomyocytes from peroxidative injury.Dec 31, 2018

Piceatannol could inhibit α-synuclein fibrillation and toxicity by forming soluble non-toxic α-synuclein/polyphenol oligomers.Jun 14, 2016

Piceatannol could protect against oxidative injury and collagen synthesis during pulmonary fibrosis.Sep 30, 2022

Piceatannol enhances cisplatin sensitivity in ovarian cancer.Aug 15, 2013

Piceatannol enhances TRAIL-induced apoptosis in human leukemia THP-1 cellsMar 31, 2011

Piceatannol exhibits selective toxicity to multiple myeloma cells.Nov 30, 2014

Piceatannol has a superior effect to resveratrol in promoting astrocyte differentiation.Oct 11, 2016

Piceatannol has an anti-cancerogenic effect on PANC-1 and MIA PaCa-2 cells.Oct 18, 2022

Piceatannol induces apoptosis in DU145 human prostate cancer cells. Sep 30, 2009

Piceatannol induces G1 cell cycle arrest in androgen-insensitive DU145 human prostate cancer cells.Nov 27, 2009

Piceatannol

View the Evidence:
111 Abstracts with Piceatannol Research