Pine Bark Extract

Name	AC	CK
Hypertension	9	92
Inflammation	7	55
Oxidative Stress	11	54
Erectile Dysfunction	5	50
Osteoarthritis	6	44
Diabetes Mellitus: Type 2	6	42
Cognitive Decline/Dysfunction	4	31
Melasma	3	31
Aging Skin	3	30
C-Reactive Protein	2	30
Coronavirus Infection	3	30
Glaucoma	3	30
Asthma	3	23
Atherosclerosis	3	22
Asthma: Bronchial	1	20
Athletic Performance	2	20
Athletic Performance: Recovery	2	20
Attention Deficit Disorder with Hyperactivity	3	20
Chronic Venous Insufficency	2	20
Deep Vein Thrombosis	2	20
Diabetic Microangiopathy	2	20
Halitosis	1	20
Headache: Migraine	2	20
Hemorrhoids	2	20
Lower Urinary Tract Symptoms	2	20
Metabolic Diseases	1	20
Metabolic Syndrome X	1	20
Sperm Count: Low	2	20
Diabetes: Cardiovascular Illness	2	14
Sperm Quality: Low	3	14
Lipid Peroxidation	2	12
Prostatic Hyperplasia: Benign	2	12
Psoriasis	2	12
Radiation Induced Illness	2	12
Cardiovascular Diseases	2	11
Cervical Cancer	8	11
Endothelial Dysfunction	2	11
Fibrosarcoma	2	11
Attention Deficit Hyperactivity Disorder	1	10
Behcet Syndrome	1	10
Bladder Dysfunction	1	10
Brain Edema	1	10
CRP	1	10
Cardiovascular Disease	1	10
Cardiovascular Disease: Prevention	1	10
Chemotherapy	1	10
Common Cold	1	10
Dysmenorrhea	1	10
Edema	1	10
Elevated CRP	1	10
Endothelial Damage	1	10
Fibrinogen: Elevated	1	10
Fibromyalgia	1	10
Gulf War Syndrome	1	10
Headache	1	10
Homocysteine: Elevated	1	10
Hot Flash	1	10
Hypoglycemia	1	10
Hypothyroidism	1	10
Intermittent Claudication	1	10
Intraocular hypertension	1	10
Irritable Bowel Syndrome	1	10
Jet Lag	1	10
Kidney Diseases	1	10
Learning disorders	1	10
Lupus Erythematosus: Systemic	1	10
Lupus-Like Syndrome	1	10
Menopausal Syndrome	1	10
Microangiopathy	1	10
Migraine Disorders	1	10
Osteoarthritis: Knee	1	10
Parkinson's Disease	1	10
Perimenopausal Syndrome	1	10
Peripheral Arterial Disease	1	10
Post-Thrombotic Syndrome	1	10
Postmenopausal Disorders	1	10
Premenopausal Disorders	1	10
Pulmonary Fibrosis	1	10
Raynaud Disease	1	10
Sjogren's Syndrome	1	10
Skin Diseases	1	10
Smoking: Cardiovascular Disease	1	10
Thromboembolism	1	10
Thrombophlebitis	1	10
Urinary Tract Infections	1	10
Varicose Veins: Postpartum	1	10
Vasculitis	1	10
Venous Thrombosis	1	10
Chemotherapy-Induced Toxicity: Cisplatin	5	9
Diabetes Mellitus: Type 1	3	5
Obesity	3	5
Aging	1	4
Alzheimer's Disease	2	4
Chronic Obstructive Pulmonary Disease	2	4
DNA damage	2	4
Diabetic Amyotrophy	1	4
Diabetic Ulcer	1	4
Hepatic Steatosis	2	4
Hepatitis C	3	4
Hyperglycemia	2	4
Lipopolysaccharide-Induced Toxicity	3	4
Thrombosis	1	4
Brain Injury: Traumatic	2	3
Breast Cancer	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Allergic Conjunctivitis	1	2
Allergic Rhinitis	1	2
Allergies	2	2
Androgen Deficiency	1	2
Atopic Dermatitis	1	2
Candida Infection	1	2
Cataract	1	2
Cerebral Ischemia	1	2
Chemically-Induced Liver Damage	1	2
Depression	1	2
Dermatitis	1	2
Epilepsy	1	2
Fluoride Toxicity	1	2
Hydrogen Peroxide Induced Toxicity	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Kidney Damage: Drug-Induced	1	2
Lupus Erythematosus: Cutaneous	1	2
Myocardial Ischemia	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Periodontitis	1	2
Radiation Induced Illness: Enteritis	1	2
Scars	1	2
Sepsis	1	2
Skin Cancer: Prevention	1	2
Spinal Cord Injuries	1	2
Stress	1	2
Sunburn	1	2
Venous Ulcer	1	2
Wound Healing	1	2
Wound Healing: Delayed	1	2
Aging: Brain	1	1
Anaphylaxis	1	1
Anemia: Hemolytic	1	1
Bacterial Infections	1	1
Brain Inflammation	1	1
Brain: Microglial Activation	1	1
Cancer Metastasis	1	1
Cancers: All	1	1
Colon Cancer	1	1
Dry Eye Syndromes	1	1
Endometriosis	1	1
Enterococcus Infections	1	1
Epstein-Barr Virus Infections	1	1
Escherichia coli Infections	1	1
Eye Diseases	1	1
Gastric Cancer	1	1
Gingivitis	1	1
Glucosephosphate Dehydrogenase Deficiency	1	1
Gout	1	1
HIV Infections	1	1
Hyperpigmentation	1	1
Liver Cancer	1	1
Low Human Growth Hormone	1	1
Lung Cancer	1	1
Oral Cancer	1	1
Ovarian Cancer	1	1
Pancreatic Cancer	1	1
Peroxynitrite Toxicity	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Sickle Cell Anemia	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Antioxidants	39	174
Anti-Inflammatory Agents	24	115
Antihypertensive Agents	7	82
Hypoglycemic Agents	7	72
Neuroprotective Agents	11	43
Platelet Aggregation Inhibitors	4	40
Anti-Bacterial Agents	5	34
Analgesics	3	30
Anticholesteremic Agents	2	30
Prophylactic Agents	3	30
Hypolipidemic	4	23
Antineoplastic Agents	3	21
Fertility Agents: Male	2	20
Apoptotic	10	19
Antiproliferative	6	15
NF-kappaB Inhibitor	5	15
Cardioprotective	3	13
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	13
Heme oxygenase-1 up-regulation	2	11
Anti-Fibrotic	1	10
Calcium Channel Blockers	1	10
Catalase Up-Regulation	1	10
Interleukin-6 Downregulation	1	10
Osteoprotective	1	10
Chemoprotective Agents	5	9
Hepatoprotective	5	9
Malondialdehyde Down-regulation	4	8
Antiviral Agents	4	5
Cytoprotective	1	5
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	5
Anti-Apoptotic	2	4
Anti-thrombotic	1	4
Glutathione Upregulation	2	4
Immunomodulatory	2	4
Interleukin-4 downregulation	2	4
Renoprotective	2	4
Alpha-glucosidase inhibitor	2	3
Anti-metastatic	3	3
Cell cycle arrest	3	3
Chemopreventive	2	3
Alpha-amylase inhibitor	1	2
Anti-Allergic Agents	2	2
Anti-Ulcer Agents	1	2
Anti-atherogenic	1	2
Anticarcinogenic Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Bcl-2 protein down-regulation	2	2
Chemotherapeutic	2	2
Chondroprotective	1	2
DNA Repair Up-regulation	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-10 downregulation	1	2
Interleukin-5 downregulation	1	2
MicroRNA modulator	1	2
Radioprotective	1	2
Superoxide Dismutase Up-regulation	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
interleukin-13 down-regulation	1	2
Anti-Angiogenic	1	1
Anti-HIV Agents	1	1
Antimicrobial	1	1
Chemosensitizer	1	1
Cytotoxic	1	1
Enzyme Inhibitors	1	1
Gastrointestinal Agents	1	1
Histamine Antagonists	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Nitric Oxide Inhibitor	1	1
Photoprotective	1	1
Secretagogue	1	1
Xanthine oxidase inhibitor	1	1

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Tradit Complement Med. 2017 Jan ;7(1):117-120. Epub 2016 Jun 11. PMID: 28053897

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : L-arginine, Pycnogenol (Pine Bark)

Diseases : Bladder Dysfunction , Lower Urinary Tract Symptoms

[+]

Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary open-angle glaucoma.Dec 31, 2020

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Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2018 ;64(3):185-191. PMID: 29962429

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Pine Bark Extract, Pycnogenol (Pine Bark)

Diseases : Halitosis

Pharmacological Actions : Anti-Bacterial Agents

[+]

Pine bark extract significantly lowers pain medication requirement in dysmenorrhea.Aug 01, 2009

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Pubmed Data : Prev Med. 2009 Aug-Sep;49(2-3):184-9. Epub 2009 Jun 23. PMID: 18567279

Pubmed Data : Biomed Pharmacother. 2006 Jan;60(1):5-9. Epub 2005 Oct 26. PMID: 16330178

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Pine Bark Extract, Pycnogenol (Pine Bark)

Diseases : Inflammation

[+]

Pinebark reduces urinary catecholamines (excitatory neurotransmitters) and reduces hyperactivity in children with ADHD. Jun 01, 2007

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Pubmed Data : Nutr Neurosci. 2007 Jun-Aug;10(3-4):151-7. PMID: 18019397

Article Published Date : Jun 01, 2007

Study Type : Human Study

Additional Links

Substances : Pine Bark Extract

Diseases : Attention Deficit Disorder with Hyperactivity

[+]

Pinus radiata bark extract and vitamin C led to a 50% reduction of frequency and severity of headaches.Feb 28, 2013

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Pubmed Data : Acta Neurol Taiwan. 2013 Mar ;22(1):13-21. PMID: 23479241

Article Published Date : Feb 28, 2013

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Pubmed Data : Arch Ital Urol Androl. 2015 Sep ;87(3):190-3. Epub 2015 Sep 30. PMID: 26428638

Article Published Date : Aug 31, 2015

Study Type : Human Study

Additional Links

Substances : Arginine, Pycnogenol (Pine Bark)

Diseases : Erectile Dysfunction, Sperm Count: Low, Sperm Quality: Low

Pharmacological Actions : Antioxidants, Fertility Agents: Male

Additional Keywords : Plant Extracts

[+]

Pycnogenol appears to be an effective and safe supplementary management in healthy subjects with idiopathic back pain.Nov 30, 2021

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Pubmed Data : Panminerva Med. 2021 Dec ;63(4):472-477. PMID: 34915691

Pycnogenol improves endothelial function of hypertensive patients.Jan 02, 2004

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Pubmed Data : Life Sci. 2004 Jan 2;74(7):855-62. PMID: 14659974

Article Published Date : Jan 02, 2004

Study Type : Human Study

Additional Links

Substances : Flavonoids, Pycnogenol (Pine Bark)

Diseases : Endothelial Dysfunction, Hypertension

Pharmacological Actions : Platelet Aggregation Inhibitors

Additional Keywords : Plant Extracts

[+]

Pycnogenol improves the signs and symptoms of postpartum varicose veins.Feb 28, 2017

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Pubmed Data : Int J Angiol. 2017 Mar ;26(1):12-19. Epub 2014 May 29. PMID: 28255210

Pubmed Data : Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18927527

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Flavonoids, Pycnogenol (Pine Bark)

Diseases : Chemotherapy, Deep Vein Thrombosis, Radiation Induced Illness

Pharmacological Actions : Antineoplastic Agents

Additional Keywords : Drug Side Effect Attenuation

[+]

Pycnogenol may be a useful supplementation for the management of Behçet syndrome.Jul 31, 2018

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Pubmed Data : Minerva Cardioangiol. 2018 Aug ;66(4):386-390. PMID: 29975020

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Pubmed Data : Minerva Endocrinol. 2019 Mar ;44(1):97-101. PMID: 30561176

Article Published Date : Feb 28, 2019

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

Additional Keywords : Medication Reduction

[+]

Pycnogenol prevents damage in the microcirculation of hypertensive patients, and allows the dose of anti-hypertensive drugs to be reduced in most patients.Oct 01, 2006

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Pubmed Data : Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4. PMID: 17000888

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Pubmed Data : J Neurosurg Sci. 2022 Aug ;66(4):371-377. PMID: 36153882

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Pubmed Data : Panminerva Med. 2019 Dec ;61(4):457-463. PMID: 32043843

Article Published Date : Nov 30, 2019

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Athletic Performance

Therapeutic Actions : Exercise, Exercise: Running

[+]

Restless legs syndrome: prevention with Pycnogenol and improvement of the venoarteriolar response.May 31, 2022

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Pubmed Data : Panminerva Med. 2022 Jun ;64(2):253-258. PMID: 35815767

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Pubmed Data : Minerva Ginecol. 2017 Feb ;69(1):29-34. PMID: 28116886

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Pubmed Data : Complement Ther Med. 2021 Feb 18 ;58:102689. Epub 2021 Feb 18. PMID: 33610726

Article Published Date : Feb 17, 2021

Study Type : Human Study

Additional Links

Substances : Pine Bark Extract

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

[+]

These results indicate the efficacy of Pycnogenol supplementation in improving control of the most common clinical aspects of psoriasis.Feb 28, 2014

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Pubmed Data : Panminerva Med. 2014 Mar ;56(1):41-8. PMID: 24637472

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Pubmed Data : Int J Environ Res Public Health. 2021 03 3 ;18(5). Epub 2021 Mar 3. PMID: 33802272

Article Published Date : Jan 02, 2021

Study Type : Human Study

Additional Links

Substances : Curcumin, Frankincense, Pine Bark Extract

Diseases : Gulf War Syndrome

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

[+]

Xerostomia and prevention of dryness with a Pycnogenol mouth spray.May 09, 2023

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Pubmed Data : Minerva Gastroenterol (Torino). 2023 May 10. Epub 2023 May 10. PMID: 37162467

Article Published Date : May 09, 2023

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Xerostomia

[+]

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Pubmed Data : Antiviral Res. 2014 Nov 20 ;113C:93-102. Epub 2014 Nov 20. PMID: 25446333

Article Published Date : Nov 19, 2014

Study Type : Transgenic Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Hepatitis C

Pharmacological Actions : Antiviral Agents

[+]

Neuroprotective and anti-inflammatory effects of Pinus densiflora bark extract.Jul 28, 2021

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Pubmed Data : Molecules. 2021 Jul 29 ;26(15). Epub 2021 Jul 29. PMID: 34361744

Article Published Date : Jul 28, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Pine Bark Extract, Polyphenols

Diseases : Brain Ischemia, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Orally administered pycnogenol may serve to prevent NASH-induced liver damage.Sep 30, 2012

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Pubmed Data : Phytother Res. 2012 Oct ;26(10):1572-4. Epub 2012 Feb 1. PMID: 22294490

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Hepatic Steatosis, Nonalcoholic fatty liver disease (NAFLD)

[+]

Pine bark and needle extract have blood-sugar lowering properties. Jun 01, 2005

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Pubmed Data : Nutrition. 2005 Jun;21(6):756-61. PMID: 15925302

Article Published Date : Jun 01, 2005

Study Type : Animal Study

Additional Links

Substances : Pine Bark Extract, Pine Needle

Diseases : Hyperglycemia

Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor

Additional Keywords : Plant Extracts

[+]

Pine bark extract could be a therapeutic strategy for controlling COPD progression.May 31, 2017

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Pycnogenol could be a potential prophylaxis or treatment for atherosclerosis in humans.Jun 15, 2016

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Pubmed Data : J Cardiovasc Pharmacol. 2016 Jun 16. Epub 2016 Jun 16. PMID: 27322603

Article Published Date : Jun 15, 2016

Study Type : Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Atherosclerosis

Pharmacological Actions : Anti-atherogenic, Anti-Inflammatory Agents, Antioxidants

[+]

Pycnogenol had a protective effect against acute hepatotoxicity induced by cisplatin.Nov 30, 2014

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Pubmed Data : J Ethnopharmacol. 2016 Oct 7. Epub 2016 Aug 7. PMID: 27725237

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Pubmed Data : J Diabetes Res. 2018 ;2018:9713259. Epub 2018 Jan 17. PMID: 29577045

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Pubmed Data : Gen Physiol Biophys. 2022 Sep ;41(5):473-481. PMID: 36222345

Article Published Date : Aug 31, 2022

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Pubmed Data : Biomed Res Int. 2014 ;2014:942927. Epub 2014 May 13. PMID: 24901001

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Depression, Oxidative Stress, Stress

Pharmacological Actions : Antidepressive Agents, Antioxidants

Additional Keywords : Plant Extracts

[+]

Pycnogenol treatment attenuated α-chlorohydrin-induced spermatotoxicity through antioxidant and antiapoptotic effects.Feb 28, 2014

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Pubmed Data : Phytother Res. 2014 Mar ;28(3):451-7. Epub 2013 Jun 21. PMID: 23788506

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Pubmed Data : Int J Mol Sci. 2016 Dec 9 ;17(12). Epub 2016 Dec 9. PMID: 27941690

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Pubmed Data : Front Pharmacol. 2019 ;10:694. Epub 2019 Jul 3. PMID: 31333448

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Chemical composition and antimicrobial activity of essential oils from the aerial parts of Pinus eldarica.Sep 02, 2019

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Pubmed Data : Curr Rheumatol Rep. 2018 Sep 19 ;20(11):72. Epub 2018 Sep 19. PMID: 30232562

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Pubmed Data : Res Pharm Sci. 2016 Jan-Feb;11(1):58-64. PMID: 27051433

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Pine Bark Extract

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Essential Oils, Plant Extracts

[+]

P. eldarica could be considered as a potential cytotoxic candidate.Nov 30, 2016

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Pubmed Data : Nat Prod Res. 2020 Nov 29:1-5. Epub 2020 Nov 29. PMID: 33251860

Article Published Date : Nov 28, 2020

Study Type : In Vitro Study

Additional Links

Substances : Pine Bark Extract

Diseases : Bacterial Infections

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants

[+]

Pine bark extract could reduce viability and induce apoptosis in HeLa cells.Mar 31, 2014

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Pubmed Data : Rev Med Chir Soc Med Nat Iasi. 2014 Apr-Jun;118(2):551-7. PMID: 25076730

Article Published Date : Mar 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Pine Bark Extract, Polyphenols

Diseases : Cervical Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Plant Extracts, Procyanidins

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Pine bark extract reduces inflammation and may provide therapeutic benefits to those with inflammatory skin disorders.Jan 15, 2000

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Pubmed Data : Free Radic Biol Med. 2000 Jan 15;28(2):219-27. PMID: 11281289

Article Published Date : Jan 15, 2000

Study Type : In Vitro Study

Additional Links

Substances : Pine Bark Extract, Pycnogenol (Pine Bark)

Diseases : Dermatitis, Lupus Erythematosus: Cutaneous, Psoriasis

[+]

Pine bark extract selectively inhibits liver cancer cells. Feb 03, 2001

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Pubmed Data : BMJ. 2001 Feb 3;322(7281):266-70. PMID: 15798999

Article Published Date : Feb 03, 2001

Pinus massoniana Lamb bark extract is effective for use in the stabilization of HCV replication and active liver inflammation.Feb 28, 2015

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Pubmed Data : Pharm Biol. 2015 Mar ;53(3):451-6. Epub 2014 Dec 4. PMID: 25471218

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Pine Bark Extract

Diseases : Hepatitis C

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells.Jul 11, 2016

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Pubmed Data : Cell Biol Toxicol. 2016 Jul 12. Epub 2016 Jul 12. PMID: 27400986

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Pubmed Data : In Vivo. 2020 Jul-Aug;34(4):1835-1843. PMID: 32606153

Article Published Date : Jun 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Pine Bark Extract

Diseases : Oxidative Stress, Smoking

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

[+]

Pycnogenol chewing gum minimizes gingival bleeding and plaque formation.Jul 01, 2002

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Pubmed Data : Phytomedicine. 2002 Jul;9(5):410-3. PMID: 12222660

Article Published Date : Jul 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Gingivitis

[+]

Pycnogenol has antidiabetic activity through inhibition of alpha-glucosidase. Jul 01, 2007

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Pubmed Data : Diabetes Res Clin Pract. 2007 Jul;77(1):41-6. Epub 2006 Nov 13. PMID: 17098323

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Pubmed Data : J Clin Biochem Nutr. 2016 Jan ;58(1):40-7. Epub 2015 Dec 8. PMID: 26798196

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Dose Response

[+]

Pycnogenol, a procyanidin-rich extract from French maritime pine, inhibits intracellular replication of HIV-1 as well as its binding to host cells.Jul 01, 2008

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Pubmed Data : Jpn J Infect Dis. 2008 Jul;61(4):279-85. PMID: 18653969

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Pubmed Data : Nutrients. 2022 Apr 12 ;14(8). Epub 2022 Apr 12. PMID: 35458159

Article Published Date : Apr 11, 2022

Study Type : In Vitro Study

Additional Links

Substances : Pine Bark Extract

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor

Additional Keywords : Plant Extracts

[+]

Treatment of melasma: a review of less commonly used antioxidants.Aug 19, 2020

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Pubmed Data : Int J Dermatol. 2020 Aug 20. Epub 2020 Aug 20. PMID: 32815582

Article Published Date : Aug 19, 2020

Study Type : Review

Additional Links

Substances : Ginseng (Korean), Grape Seed Extract, Niacinamide, Parsley, Pycnogenol (Pine Bark), Silymarin, Zinc

Diseases : Melasma

Pharmacological Actions : Antioxidants

[+]

Pine bark extract significantly reduces the symptoms of ADHD in children.Sep 01, 2006

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Pubmed Data : Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35. Epub 2006 May 13. PMID: 16699814

Article Published Date : Sep 01, 2006

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Substances : Pine Bark Extract

Diseases : Attention Deficit Disorder with Hyperactivity

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View the Evidence: 213 Abstracts with Pine Bark Extract Research

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Present systematic review and meta-analysis suggested Pycnogenol consumption can decrease the level of CRP and have anti-inflammatory effect.Mar 31, 2018

This meta-analysis suggests that pycnogenol may have a role in preventing cardiometabolic disease.Sep 30, 2019

This meta-analysis with nine trials provides better evidence that Pycnogenol exerts beneficial effects on blood pressure.May 31, 2018

Projected supportive effects of Pycnogenol Ⓡ in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection.Nov 30, 2020

"Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition."Sep 01, 2011

A combination of bilberry and pycnogenol reduces intraocular hypertension and may lower the risk of symptomatic glaucoma. Jan 01, 2008

A combination of pine bark extract and L-arginine is effective for long-term improvement of erectile function. Feb 22, 2010

A multi-nutrient mixture of marine proteins, alpha-lipoic acid, pine bark extract, vitamins and minerals is safe and efficacious in the treatment of aging symptoms of the skin in women. May 01, 2005

A multi-nutrient mixture of vitamin C, vitamin E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and pycnogenol improves visible signs of ageing in women 45-73 years of age. Jul 01, 2004

A polyphenol-rich supplement from Pinus massoniana bark extract led to a clinically and statistically significant reduction in systolic blood pressure.Oct 20, 2022

Administration of Pycnogenol leads in improvement of erectile function in patients with diabetes.Dec 31, 2018

Antioxidant effects of a polyphenol-rich dietary supplement incorporating Pinus massoniana bark extract.Aug 10, 2022

Antioxidant therapy with pine bark, vitamin C and vitamin E may be beneficial in the treatment of drug-refractory migraine possibly reducing headache frequency and severity.May 01, 2006

Chronic venous insufficiency and venous microangiopathy: management with compression and pycnogenol.Jul 31, 2019

Complementary effects of pine bark extract supplementation on inattention, impulsivity, and antioxidative status in children with ADHD.Feb 07, 2021

Edicare, a supplement containing PAA might be an effective potential therapeutic alternative for elderly patients with LUTS.Dec 31, 2016

Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary open-angle glaucoma.Dec 31, 2020

Episodic primary migraine headache: prophylaxis with Pycnogenol precents attacks and controls oxidative stress.Oct 24, 2019

French maritime pine bark extract (Pycnogenol) displays anti-inflammatory effects in vivo.Jan 01, 2006

French maritime pine bark extract supplements can be used as a preventive strategy for bone loss in postmenopausal osteopenic women.Mar 23, 2019

Idiopathic myalgic pain (fibromyalgia): supportive management and prevention with Pycnogenol.Feb 28, 2021

Individuals using the Army Physical Fitness Test while supplementing with Pycnogenol had a lower increase in oxidative stress with a faster recovery to almost normal levels.Nov 30, 2013

Intake of the ProVens dietary supplement could improve the control of intraocular pressure, particularly in patients with ocular hypertension.Dec 31, 2014

Management of mild, primary Raynaud Syndrome: supplementation with pycnogenol.Sep 30, 2019

Maritime pine extract was effective at affording protection from oxidative stress post-exercise.Mar 18, 2019

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Micronized palmitoylethanolamide, hempseed oil, and maritime pine bark dry extract for pelvic pain.Feb 13, 2023

Oligopin improves lipid cardiovascular profile and represents one of the scarce ways to increase HDL-c in stage-1-hypertensive subjects.Nov 14, 2016

Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.Dec 31, 2011

Oral intake of Pycnogenol might have the potential to reduce hair loss in postmenopausal women.Dec 31, 2022

Pcynogenol has protective effects on kidney flow and function in hypertension and reduces C-reactive protein. Mar 01, 2010

Pcynogenol significantly reduces severity of symptoms in patients with systemic lupus erythematosus. Dec 01, 2001

Pine bark extract chewing gum is effective in reducing oral malodor.Dec 31, 2017

Pine bark extract significantly lowers pain medication requirement in dysmenorrhea.Aug 01, 2009

Pine bark extract significantly prolonged the lag time of LDL oxidation.Dec 31, 2014

Pine bark extract significantly reduces oxidative stress in children with ADHD.Jan 01, 2006

Pine bark extract significantly reduces pain in osteoarthritis.Aug 01, 2008

Pine Bark Extract, Saffron, Saw Palmetto for three months significantly improved sexual function, urinary symptoms.Aug 31, 2016

Pine bark inhibits Cox-1 and Cox-2 enzymes, reducing inflammation.Jan 01, 2006

Pinebark reduces urinary catecholamines (excitatory neurotransmitters) and reduces hyperactivity in children with ADHD. Jun 01, 2007

Pinus radiata bark extract and vitamin C led to a 50% reduction of frequency and severity of headaches.Feb 28, 2013

Prevention of recurrent venous thrombosis and post-thrombotic syndrome.May 31, 2018

Pycnogenol and Centella Asiatica reduce the progression of arterial plaques and the progression to clinical stages.Oct 26, 2015

Pycnogenol and L-arginine combination is helpful for infertile men to ameliorate simultaneously quality of sperms as well as erectile functions.Aug 31, 2015

Pycnogenol appears to be an effective and safe supplementary management in healthy subjects with idiopathic back pain.Nov 30, 2021

Pycnogenol appears to positively affect hemorrhoid signs and symptoms in the months after pregnancy.Jan 31, 2014

Pycnogenol has antidiabetic action in patients with type 2 diabetes. Oct 08, 2004

Pycnogenol has shown a large number of positive effects in subjects with initial cognitive impairment.May 31, 2018

Pycnogenol has therapeutic value in the prevention of jet lag in healthy and hypertensive patients. Oct 01, 2008

Pycnogenol improves diabetes control, lowers cardiovascular disease risk factors, and reduces the need for hypertension medication in type diabetic patients. May 01, 2008

Pycnogenol improves endothelial function of hypertensive patients.Jan 02, 2004

Pycnogenol improves the signs and symptoms of postpartum varicose veins.Feb 28, 2017

Pycnogenol is efficacious as an adjunct in the management of mild-to-moderate childhood asthma. Dec 01, 1998

Pycnogenol is well-tolerated and increases the effectiveness of broad-spectrum sunscreen and the triple combination in the treatment of facial melasma in women.Aug 24, 2020

Pycnogenol may alleviate adverse effects in oncologic treatment, e.g. deep vein thrombosis.Jan 01, 2008

Pycnogenol may be a useful supplementation for the management of Behçet syndrome.Jul 31, 2018

Pycnogenol may be an important option for self-management of benign prostatic hyperthrophy in otherwise healthy men.Jul 31, 2018

Pycnogenol may exert anti-inflammatory activity in osteoarthritic joints. Jan 01, 2008

Pycnogenol may offer a significant option for managing some of the signs and symptoms associated with post-COVID-19 syndrome.Dec 31, 2020

Pycnogenol patch was effective in controlling mild to moderate pain and inflammations and its related symptoms in subjects with knee osteoarthritis.Feb 28, 2019

Pycnogenol prevents damage in the microcirculation of hypertensive patients, and allows the dose of anti-hypertensive drugs to be reduced in most patients.Oct 01, 2006

Pycnogenol prevents oxidative stress and side effects in patients with hypothyroidism during levothyroxine treatment.May 31, 2019

Pycnogenol prevents venous thrombosis and thrombophlebitis in long-haul flights.Oct 01, 2004

Pycnogenol rapidly reduces clinical symptoms in patients with chronic venous insufficiency and venous microangiopathy. Oct 01, 2006

Pycnogenol reduces cramps and muscular pain common in diabetics and claudicants. Jun 18, 2007

Pycnogenol reduces smoking-induced platelet aggregation as effectively as aspirin, with longer duration of action and with far less prolongation of bleeding time.Aug 15, 1999

Pycnogenol supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment.Jul 31, 2022

Pycnogenol supplementation appears to make regression faster for all symptoms in comparison with controls.Dec 31, 2013

Pycnogenol supplementation for 12 months appears to improve cognitive function and oxidative stress.Nov 30, 2015

Pycnogenol supplementation for 12 weeks appears to improve cognitive function and oxidative stress in healthy professionals.Nov 30, 2014

Pycnogenol supplementation improves cognitive function, attention and mental performance in students.Sep 01, 2011

Pycnogenol supplementation improves the control of irritable bowel syndrome symptoms.May 31, 2018

Pine Bark Extract

View the Evidence:
213 Abstracts with Pine Bark Extract Research