Piperidines

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41 Diseases Researched for Piperidines

Name	AC	CK
Nonalcoholic fatty liver disease (NAFLD)	3	23
Liver Cirrhosis	2	13
Alzheimer's Disease	2	12
Anxiety Disorders	1	10
Coronavirus Infection	1	10
Dementia	1	10
Depression	1	10
Depressive Disorder	1	10
Oxidative Stress	3	6
Hyperlipidemia	2	4
Lung Cancer	2	4
Inflammation	1	3
Benzo[a]pyrene-induced Toxicity	1	2
Brain: Oxidative Stress	1	2
Cadmium Poisoning	1	2
Cancer Stem Cells	2	2
Chemotherapy-Induced Toxicity	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Complex Regional Pain Syndrome: Type I	1	2
Drug-Induced Toxicity: Epilepsy Drugs	1	2
Epilepsy	1	2
Heavy Metal Toxicity	1	2
Hyperalgesia	1	2
Hypertension	1	2
Hyperthyroidism	1	2
Oral Cancer	1	2
Squamous cell carcinoma	1	2
Thyroid Diseases	1	2
Tumors	2	2
Breast Cancer	1	1
Cancers: Drug Resistant	1	1
Cancers: Radiation-Resistant	1	1
Candida Albicans	1	1
Colon Cancer	1	1
Immune Disorders: Low Immune Function	1	1
Leishmaniasis	1	1
Low Immune Function: Splenic Dysfunction	1	1
Melanoma	1	1
Ovarian Cancer	1	1
Triglycerides: Elevated	1	1
Vitiligo	1	1

27 Pharmacological Actions Researched for Piperidines

Name	AC	CK
Hepatoprotective	3	23
Antidepressive Agents	2	12
Hypoglycemic Agents	1	10
Antioxidants	5	9
Antiproliferative	7	8
Anticarcinogenic Agents	5	7
Apoptotic	5	7
Antineoplastic Agents	3	5
Neuroprotective Agents	2	4
Anti-Inflammatory Agents	1	3
NF-kappaB Inhibitor	1	3
Analgesics	1	2
Chemopreventive	1	2
Hypotensive	1	2
Malondialdehyde Down-regulation	1	2
Monoamine Oxidase Inhibitors	1	2
Neuritogenic	1	2
Superoxide Dismutase Up-regulation	1	2
Antifungal Agents	1	1
Antimutagenic Agents	1	1
Chemosensitizer	1	1
Enzyme Inhibitors	1	1
GABA Modulators	1	1
Immunomodulatory	1	1
Leishmanicidal	1	1
Nitric Oxide Inhibitor	1	1
Radiosensitizer	1	1

Research Articles 31
Cumulative Knowledge Score 50
Overall Research Rating GOOD

View the Evidence:
31 Abstracts with Piperidines Research

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View the Evidence: 31 Abstracts with Piperidines Research

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Bioavailability Study: Piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.May 01, 1998

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Gingko biloba compares favorably to the drug Aricept (donepezil) for the treatment of Alzheimer's dementia.Sep 01, 2006

Results of this clinical trial suggest that short-term treatment with curcumin plus piperine administration improves NAFLD severity.Dec 31, 2020

The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis.Jan 10, 2024

The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness.Jun 05, 2022

Piperine alleviates nonalcoholic steatohepatitis by inhibiting NF-κB-mediated hepatocyte pyroptosis.Dec 31, 2023

Curcumin and piperine prevents chemically-induced oral cancer. Feb 01, 2009

Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.May 01, 2010

Electroacupuncture induces antihyperalgesic effect through endothelin-B receptor in the chronic phase of a mouse model of complex regional pain syndrome type I.Jan 12, 2018

Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity.Feb 28, 2013

Piperine exhibit chempreventive effects in chemically-induced lung cancer in mice. Mar 01, 2005

Piperine may extend its chemopreventive effect through modulating the protein bound carbohydrate levels, as they are one of the indicators of tumorigenesis.Jan 01, 2006

Piperine protects against cisplatin-induced toxicity in auditory cells.Sep 01, 2007

Piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in high fat fed antithyroid drug treated rats.Nov 01, 2006

Piperine, a major component of black pepper, inhibits cadmium-induced immunsuppression.Aug 14, 2006

Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.Jan 01, 2010

Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats.Sep 01, 2007

The antidepressant-like effect of piperine is associated wtih its inhibitory effect on monoamine oxidase.Jul 01, 2005

A variety of natural compounds may inhibit cancer stem cells. Sep 01, 2011

Black pepper and its pungent principle-piperine: a review of diverse physiological effects.Jan 01, 2007

Black pepper contains pellitorine, a potential anti-cancer lead compound against tumor cell lines.Jan 01, 2010

If UVA radiation is used with piperine in the treatment of vitiligo, application of the compound and irradiation should be staggered to minimize photoisomerization.Nov 01, 2006

Piperine and phenylamide acted synergistically on the leishmania amazonensis parasites.Nov 30, 2011

Piperine can be considered a potential anticancer agent that can increase chemotherapy effectiveness in cancer patients.Apr 18, 2021

Piperine is a GABA modulator.Feb 26, 2010

Piperine suppressed the growth of human melanoma cells.Mar 31, 2019

Piperine, a major component of black pepper, has cyptoprotective and immunomodulating properties.Dec 08, 2007

Preventive compounds curcumin and piperine are capable of targeting breast stem cells. Aug 01, 2010

Resveratrol and piperine enhance radiosensitivity of tumor cells.Mar 31, 2012

Synergistic interaction of piperine and thymol on attenuation of the biofilm formation, hyphal morphogenesis and phenotypic switching in Candida albicans.Dec 31, 2020

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Piperidines

View the Evidence:
31 Abstracts with Piperidines Research