Piperine

Name	AC	CK
Diabetes Mellitus: Type 2	5	26
Oxidative Stress	6	19
Fibrosis	2	12
Vitiligo	2	12
Alzheimer's Disease	7	10
High Fat Diet	5	10
Metabolic Diseases	1	10
Muscle Damage: Exercise-Induced	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Ultraviolet Radiation Induced Damage	2	10
Lung Cancer	4	9
Depression	4	8
Lipopolysaccharide-Induced Toxicity	5	8
Obesity	4	8
Parkinson's Disease	5	8
Cadmium Poisoning	2	7
Inflammation	5	7
Cancers: All	6	6
Cervical Cancer	2	6
Cognitive Decline/Dysfunction	3	6
Brain Inflammation	3	5
Colorectal Cancer	4	5
Osteosarcoma	1	5
Breast Cancer	4	4
Cerebral Ischemia	2	4
Colon Cancer	4	4
Diabetes: Cognitive Dysfunction	2	4
Epilepsy	2	4
Kidney Damage	2	4
Liver Cancer	3	4
Staphylococcus aureus infection	3	4
Breast Cancer: Triple Negative	3	3
Candida Albicans	3	3
Helicobacter Pylori Infection	2	3
Leishmaniasis	2	3
Myocardial Fibrosis	2	3
Neurodegenerative Diseases	2	3
Pancreatitis	2	3
Triglycerides: Elevated	2	3
Atopic Dermatitis	1	2
Bacterial Infections	1	2
Cataract	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chronic Myeloid Leukemia	2	2
Colitis	1	2
Copper Toxicity	1	2
Coronavirus Infection	2	2
DNA damage	1	2
Depressive Disorder	1	2
Diabetic Complications	1	2
Encephalomyelitis	1	2
Endometritis	1	2
Endotoxemia	1	2
Epilepsy: Drug-Induced	1	2
Escherichia coli Infections	2	2
Fat Malabsorption	1	2
Gallstones	1	2
Gastritis	1	2
HPA Axis Dysregulation	1	2
Hyperlipidemia	1	2
Indigestion: Fats	1	2
Inflammatory Bowel Diseases	1	2
Insulin Resistance	1	2
Ischemia	1	2
Lead Poisoning	1	2
Leptin Resistance	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Lupus Nephritis	1	2
Lupus-Like Syndrome	1	2
Malabsorption Syndrome	1	2
Mastitis	1	2
Memory Disorders	1	2
Metabolic Syndrome X	1	2
Microvilli atrophy	1	2
Multiple Sclerosis	1	2
Myelotoxicity	1	2
Myocardial Ischemia	1	2
Ovarian Cancer	2	2
Periodontitis	1	2
Prostate Cancer	2	2
Sepsis	2	2
Steatorrhea	1	2
Stress	1	2
Aspergillosis	1	1
Atherosclerosis	1	1
Autism	1	1
Autoimmune Diseases	1	1
Cancer Stem Cells	1	1
Cancers: Drug Resistant	1	1
Cancers: Radiation-Resistant	1	1
Dental Implantation	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Gastric Cancer	1	1
Glioma	1	1
High Cholesterol	1	1
Huntington Disease	1	1
Hyperglycemia	1	1
Malaria	1	1
Oral Cancer	1	1
Organ Transplantation	1	1
Osteoclastoma	1	1
Pseudomonas aeruginosa	1	1
Radiation	1	1
Seizures	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Systemic Lupus Erythematosus	1	1
Thyroid Cancer	1	1
Traumatic Brain Injury	1	1

Name	AC	CK
Anti-Inflammatory Agents	30	58
Antioxidants	21	46
Neuroprotective Agents	24	42
Antiproliferative	20	26
Apoptotic	19	26
Cell cycle arrest	8	17
Hepatoprotective	4	16
Tumor Necrosis Factor (TNF) Alpha Inhibitor	10	16
Hypoglycemic Agents	4	15
Interleukin-1 beta downregulation	9	15
Hypolipidemic	3	14
Anti-Fibrotic	3	13
Cardioprotective	7	13
NF-kappaB Inhibitor	8	13
Anti-metastatic	8	12
Adiponectin upregulation	1	10
Antidepressive Agents	5	10
Bcl-2 protein down-regulation	2	10
Photoprotective	2	10
Anti-Apoptotic	5	8
Chemopreventive	6	8
Chemosensitizer	4	8
Interleukin-6 Downregulation	5	8
Anticonvulsants	3	6
Chemotherapeutic	4	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	6
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	6
Anticarcinogenic Agents	3	5
Bax/Bcl2 ratio: Increase	1	5
Caspase-3 Activation	1	5
Caspase-9 Activation	1	5
Pancreato Protective Agents	3	5
Tumor Suppressor Protein p53 Upregulation	1	5
Chemoprotective Agents	2	4
Immunomodulatory	3	4
Renoprotective	2	4
Anticholesteremic Agents	2	3
Gastroprotective	2	3
Leishmanicidal	2	3
Multidrug Resistance Gene Modulators	3	3
Angiogenesis Inhibitors	2	2
Anti-Bacterial Agents	2	2
Antihypertensive Agents	1	2
Antimicrobial	2	2
Antimutagenic Agents	1	2
Antiviral Agents	2	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Genoprotective	1	2
Immunostimulatory	1	2
Insecticides	1	2
Monoamine Oxidase Inhibitors	1	2
Prophylactic Agents	1	2
Serotonergic	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-atherogenic	1	1
Antimalarials	1	1
Cyclooxygenase 2 Inhibitors	1	1
Insecticidal	1	1
Interleukin-8 downregulation	1	1
MicroRNA modulator	1	1
Nitric Oxide Inhibitor	1	1
Nrf2 activation	1	1
Prostaglandin PGE2 downregulation	1	1
Radioprotective	1	1
Radiosensitizer	1	1
STAT3 Activation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

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Pubmed Data : Front Pharmacol. 2021 ;12:669362. Epub 2021 May 28. PMID: 34122090

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Coronavirus Infection

Additional Keywords : Morbidity, Mortality, Risk Reduction

[+]

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

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Pubmed Data : Clin Nutr. 2015 Jan 7. Epub 2015 Jan 7. PMID: 25618800

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

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Pubmed Data : Int Immunopharmacol. 2015 Jan ;24(1):50-8. Epub 2014 Nov 20. PMID: 25479727

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

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Substances : Piperine

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

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Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201

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Pubmed Data : Cutan Ocul Toxicol. 2019 Mar 1:1-8. Epub 2019 Mar 1. PMID: 30678496

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Cataract

Pharmacological Actions : Antioxidants

[+]

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

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Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

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Pubmed Data : Exp Ther Med. 2014 Jul ;8(1):260-266. Epub 2014 May 16. PMID: 24944632

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : High Fat Diet, Hyperlipidemia, Triglycerides: Elevated

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

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Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

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Pubmed Data : Inflammation. 2016 Jun ;39(3):1025-38. PMID: 26970969

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Neuroprotective Agents

[+]

Piperine enhances the antioxidant and anti-Inflammatory activities of thymoquinone against microcystin-LR-induced hepatotoxicity and neurotoxicity.Dec 31, 2018

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:1309175. Epub 2019 Apr 16. PMID: 31178949

Article Published Date : Dec 31, 2018

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Pubmed Data : Iran J Basic Med Sci. 2017 Nov ;20(11):1227-1231. PMID: 29299200

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Kidney Damage, Lead Poisoning

Pharmacological Actions : Renoprotective

[+]

Piperine has the potential to be used as a bio-enhancing agent in combination with metformin.Dec 31, 2015

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[+]

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

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[+]

The antidepressant-like effect of piperine involves the serotonergic system. Apr 06, 2011

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 6. Epub 2011 Apr 6. PMID: 21477634

Article Published Date : Apr 06, 2011

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Piperine

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Serotonergic

[+]

The antidepressant-like effect of piperine is associated wtih its inhibitory effect on monoamine oxidase.Jul 01, 2005

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Pubmed Data : Chem Pharm Bull (Tokyo). 2005 Jul;53(7):832-5. PMID: 15997146

Article Published Date : Jul 01, 2005

Study Type : Animal Study

Additional Links

Substances : Piperidines, Piperine

Pharmacological Actions : Antidepressive Agents, Monoamine Oxidase Inhibitors

[+]

These findings suggest that long-term piperine supplementation improved streptozotocin-induced cognitive impairment.Jun 10, 2018

A review of the effectiveness and therapeutic value of phytochemicals in acute pancreatitis.May 02, 2019

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Pubmed Data : Pancreatology. 2019 May 3. Epub 2019 May 3. PMID: 31079933

Article Published Date : May 02, 2019

Study Type : Review

Additional Links

Substances : Berberine, Curcumin, Ellagic Acid, Lycopene, Phyllanthus emblica, Piperine, Resveratrol

Diseases : Pancreatitis

Pharmacological Actions : Anti-Apoptotic, Pancreato Protective Agents

[+]

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

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Pubmed Data : Chem Biol Interact. 2019 Mar 29. Epub 2019 Mar 29. PMID: 30935902

Article Published Date : Mar 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine, Vitamin E

Diseases : Thyroid Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Evaluation of piperine against cancer stem cells of hepatocellular carcinoma.Feb 23, 2021

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Pubmed Data : Bioorg Chem. 2021 Feb 24 ;110:104776. Epub 2021 Feb 24. PMID: 33743225

Article Published Date : Feb 23, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic

Additional Keywords : Cancer Stem Cells

[+]

Herbal-based nano systems have promising proficiency in treatment of neurodegenerative disorders.Dec 31, 2019

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Pubmed Data : Comput Biol Med. 2021 Aug 28 ;137:104818. Epub 2021 Aug 28. PMID: 34481181

Article Published Date : Aug 27, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

In this review, they have summarized the recent progress on dietary nutraceuticals in reversing multidrug resistance.Dec 31, 2014

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(16):6831-9. PMID: 26514453

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : beta-Carotene, Bitter Melon, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Fruit: All, Fucoxanthin , Gingerol , Grape Seed Extract, Indole-3-Carbinol, Piperine, Quercetin, Resveratrol, Vegetables: All

Diseases : Cancers: All

Pharmacological Actions : Multidrug Resistance Gene Modulators

Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy

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[+]

Oxidative stress induced by piperine leads to apoptosis in Candida albicans.Jul 12, 2020

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Pubmed Data : Med Mycol. 2020 Jul 13. Epub 2020 Jul 13. PMID: 32658959

Article Published Date : Jul 12, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Candida Albicans

Pharmacological Actions : Anti-Bacterial Agents, Apoptotic

[+]

Piperine alkaloid induces anticancer and apoptotic effects in cisplatin resistant ovarian carcinoma.Oct 31, 2019

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Pubmed Data : J BUON. 2019 Nov-Dec;24(6):2316-2321. PMID: 31983100

Article Published Date : Oct 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Cancers: Drug Resistant, Ovarian Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Piperine alleviates lipopolysaccharide-induced inflammatory injury.Jun 30, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:947-954. Epub 2018 Apr 24. PMID: 29710511

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor

[+]

Piperine and celecoxib synergistically inhibit colon cancer cell proliferation.Mar 31, 2021

Pubmed Data : Sci Rep. 2016 Dec 20 ;6:39239. Epub 2016 Dec 20. PMID: 27995955

Article Published Date : Dec 19, 2016

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Antiproliferative, Apoptotic, lung cancer, Piperine

[+]

Piperine may become a potential therapeutic agent against bacterial sepsis.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2016 ;7:390. Epub 2016 Oct 20. PMID: 27812336

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Pubmed Data : Sci Pharm. 2017 Jul 3 ;85(3). Epub 2017 Jul 3. PMID: 28671634

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Pubmed Data : Iran J Public Health. 2021 May ;50(5):1037-1047. PMID: 34183962

Article Published Date : Apr 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

The use of phytochemicals may be a true therapeutic strategy for eradicating cancer through the elimination of CSCs.Dec 31, 2014

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Pubmed Data : J Nutr. 2004 Aug;134(8):1948-52.C PMID: 15284381

Article Published Date : Aug 01, 2004

Additional Links

Substances : EGCG (Epigallocatechin gallate), Piperine

Additional Keywords : Increased Bioavailability

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View the Evidence: 168 Abstracts with Piperine Research

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Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.Jan 02, 2018

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19.Dec 31, 2020

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

Simultaneous use of narrowband ultraviolet B and topical piperine has a remarkable effect on treatment of vitiligo.May 20, 2018

The use of piperine-added Curcuma longa L. was effective in the glycaemic and TG control of patients with type 2 diabetes.Feb 13, 2021

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.Aug 31, 2019

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.Jun 30, 2020

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination.Jul 14, 2020

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.May 31, 2020

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.Jan 01, 2010

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

Antioxidant effects of piperine in in-vivo cataract model induced by steroids.Feb 28, 2019

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Black Pepper reduces high-fat diet induced oxidative stress.Jan 01, 2004

Black pepper shows potential as a larvicide for the control of certain malaria vector species.Dec 31, 2015

Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.Dec 31, 2012

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.Dec 31, 2019

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own. Jul 25, 2015

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.Jul 02, 2015

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.Sep 13, 2011

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.Feb 24, 2010

Natural piperine improves lipid metabolic profile of high-fat diet-fed mice.Feb 25, 2021

Neuroprotective effect of quercetin in combination with piperine against rotenone-and iron supplement-induced Parkinson's disease.Oct 24, 2019

Oral administration of Curcuma longa associated with white pepper at doses that can be extrapolated to human exposure upon supplementation improves pro-inflammatory disorders.Dec 31, 2012

P. nigrum is a source of potent and safe antileishmanial compounds.Dec 31, 2014

Piperine alleviates doxorubicin-induced cardiotoxicity.Dec 31, 2018

Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.Nov 30, 2018

Piperine ameliorated the progression of TNBS-induced colitis.Dec 12, 2019

Piperine ameliorates trimellitic anhydride-induced atopic dermatitis-like symptoms.May 06, 2020

Piperine and Curcumin (from Turmeric) attenuates Cadmium induced immunotoxicity.Dec 01, 2008

Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.Oct 31, 2019

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease.Jul 31, 2019

Piperine can be considered as an effective bioactive molecule to suppress of body weight, improve insulin and leptin sensitivity, and regulating obesity.Sep 24, 2014

Piperine can relieve depression in rats by modulating the function of HPA axis.Jul 01, 2009

Piperine enhanced the bioavailability of curcumin and potentiated its protective effects against CUS induced cognitive impairment and associated oxidative damage in mice.Dec 06, 2012

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

Piperine enhances the antioxidant and anti-Inflammatory activities of thymoquinone against microcystin-LR-induced hepatotoxicity and neurotoxicity.Dec 31, 2018

Piperine enhances the protective effect of curcumin against 3-Nitropropionic acid induced neurotoxicity.Jul 31, 2015

Piperine has a blood pressure lowering and vasomodulator effect.Nov 01, 2008

Piperine has anticonvulsant effects in-vivo and in-vitro.Sep 02, 2015

Piperine has protective effects on lead acetate induced-nephrotoxicity in rats.Oct 31, 2017

Piperine has the potential to be used as a bio-enhancing agent in combination with metformin.Dec 31, 2015

Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration.Oct 18, 2017

Piperine may be a potential anti-inflammatory treatment both in endometritis and in other S. aureus-induced diseases.Dec 31, 2015

Piperine may be a promising prooxidant drug for the amelioration of hepatocellular carcinoma.Mar 20, 2017

Piperine may be used as a bioenhancer to improve pharmacological effect of ginsenoside Rh2 when given orally.Jan 31, 2018

Piperine may contribute to prevention or reduction of colonic inflammation.Jun 30, 2015

Piperine may have antimutagenic potential.Oct 01, 2007

Piperine may provide protection to cardiac mitochondria against copper ascorbate induced toxic injury through its antioxidant activities.Aug 31, 2014

Piperine modulates isoproterenol induced myocardial ischemia.Jan 11, 2017

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

Piperine promoted beneficial metabolism during exercise by regulating carbohydrate, fat metabolism and redox signals.Dec 31, 2016

Piperine protects against myocardial ischemia/reperfusion injury by activating the PI3K/AKT signaling pathway.Mar 31, 2021

Piperine protects against pancreatic β-cell dysfunction by alleviating macrophage inflammation in obesity.Mar 01, 2021

Piperine protects lipopolysaccharide-induced mastitis by inhibiting inflammatory response.Jul 20, 2020

Piperine reduces DNA damage and DNA-protein cross links in experimentally induced lung carcinogenesis.Nov 01, 2008

Piperine

View the Evidence:
168 Abstracts with Piperine Research