Piperine

Name	AC	CK
Oxidative Stress	13	68
Inflammation	15	59
Diabetes Mellitus: Type 2	6	36
C-Reactive Protein	3	30
Coronavirus Infection	7	25
Inflammatory Bowel Diseases	3	22
Vitiligo	3	22
Depression	6	20
Multiple Myeloma	1	15
Rheumatoid Arthritis	1	15
Breast Cancer	11	14
Alzheimer's Disease	10	13
Lipopolysaccharide-Induced Toxicity	8	13
Obesity	7	13
Fibrosis	2	12
High Fat Diet	6	12
Parkinson's Disease	8	12
Liver Cancer	6	11
Allergic Rhinitis	1	10
Allergies	1	10
Anxiety	1	10
Diabetic Retinopathy	1	10
Dysmenorrhea	1	10
Hemodialysis	1	10
Hypertension	1	10
Lung Cancer	5	10
Lupus Erythematosus: Cutaneous	1	10
Metabolic Diseases	1	10
Muscle Damage: Exercise-Induced	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Premenstrual syndrome	1	10
Stroke: Ischemic	1	10
Ultraviolet Radiation Induced Damage	2	10
Cancers: All	8	8
Colorectal Cancer	7	8
Neurodegenerative Diseases	6	8
Osteosarcoma	2	8
Cadmium Poisoning	2	7
Cervical Cancer	3	7
Candida Albicans	6	6
Chemically-Induced Liver Damage	3	6
Cognitive Decline/Dysfunction	3	6
Colon Cancer	6	6
Liver Fibrosis	3	6
Brain Inflammation	3	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Insulin Resistance	3	5
Malaria	4	5
Radiation	3	5
Staphylococcus aureus infection	4	5
Cerebral Ischemia	2	4
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetic Complications	2	4
Epilepsy	2	4
Kidney Damage	2	4
Leishmaniasis	3	4
Liver Damage: Drug-Induced	2	4
Sepsis	3	4
Arthritis	2	3
Breast Cancer: Triple Negative	3	3
Chronic Pain	1	3
Diarrhea	2	3
Escherichia coli Infections	3	3
Gastritis	2	3
Helicobacter Pylori Infection	2	3
Hepatitis C	1	3
Lung Inflammation	1	3
Myocardial Fibrosis	2	3
Oral Cancer	2	3
Pancreatitis	2	3
Prostate Cancer	3	3
Pseudomonas aeruginosa	3	3
Smoking	1	3
Squamous cell carcinoma	2	3
Triglycerides: Elevated	2	3
Wound Healing	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging	1	2
Alcohol Toxicity	1	2
Atopic Dermatitis	1	2
Bacterial Infections	1	2
Bisphenol Toxicity	1	2
Bladder Cancer	1	2
Brain Injury: Traumatic	1	2
Cataract	1	2
Chemobrain	1	2
Chronic Myeloid Leukemia	2	2
Colitis	1	2
Copper Toxicity	1	2
DNA damage	1	2
Depressive Disorder	1	2
Encephalomyelitis	1	2
Encephalopathy	1	2
Endometritis	1	2
Endotoxemia	1	2
Epilepsy: Drug-Induced	1	2
Fat Malabsorption	1	2
Gallstones	1	2
Gastric Cancer	2	2
Gastric Ulcer	1	2
HPA Axis Dysregulation	1	2
Hepatic Steatosis	1	2
Huntington Disease	2	2
Hyperlipidemia	1	2
Indigestion: Fats	1	2
Ischemia	1	2
Lead Poisoning	1	2
Leptin Resistance	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Lung Damage	1	2
Lupus Nephritis	1	2
Lupus-Like Syndrome	1	2
Malabsorption Syndrome	1	2
Mastitis	1	2
Memory Disorders	1	2
Metabolic Syndrome X	1	2
Microvilli atrophy	1	2
Multiple Sclerosis	1	2
Myelotoxicity	1	2
Myocardial Ischemia	1	2
Nephropathy	1	2
Ovarian Cancer	2	2
Periodontitis	1	2
Pesticide Toxicity	1	2
Sciatica	1	2
Steatorrhea	1	2
Stress	1	2
Stroke	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Aflatoxicosis	1	1
Aspergillosis	1	1
Atherosclerosis	1	1
Autism	1	1
Autoimmune Diseases	1	1
Bronchitis	1	1
Cancer Stem Cells	1	1
Cancers: Drug Resistant	1	1
Cancers: Radiation-Resistant	1	1
Candida Glabrata	1	1
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	1
Cholangiocarcinoma	1	1
Cholera	1	1
Dental Implantation	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Glioblastoma	1	1
Glioblastoma Multiforme	1	1
Glioma	1	1
Head and Neck Cancer	1	1
High Cholesterol	1	1
Hyperglycemia	1	1
Infection: Antibiotic Resistant	1	1
Klebsiella Infections	1	1
Liver Injury: Ischemia/reperfusion	1	1
Myocardial Infarction	1	1
Organ Transplantation	1	1
Osteoclastoma	1	1
Polycystic Ovary Syndrome	1	1
Psoriasis	1	1
Salmonella Infections	1	1
Seizures	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Steroid-Induced Toxicity	1	1
Systemic Lupus Erythematosus	1	1
Thyroid Cancer	1	1
Toxoplasma gondii Infection	1	1
Traumatic Brain Injury	1	1

Name	AC	CK
Anti-Inflammatory Agents	55	157
Antioxidants	42	139
Neuroprotective Agents	34	66
Antiproliferative	33	56
Apoptotic	29	39
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	39
Interleukin-1 beta downregulation	13	36
NF-kappaB Inhibitor	11	32
Interleukin-6 Downregulation	10	30
Hepatoprotective	11	28
Hypolipidemic	6	27
Hypoglycemic Agents	6	26
Gastrointestinal Agents	5	24
Antidepressive Agents	7	22
Cell cycle arrest	10	19
Chemosensitizer	10	17
Cyclooxygenase 2 Inhibitors	3	17
Cardioprotective	9	16
Anti-Fibrotic	4	15
Anti-metastatic	10	15
Chemotherapeutic	7	13
Superoxide Dismutase Up-regulation	3	13
Anti-Apoptotic	7	11
Adiponectin upregulation	1	10
Anti-Anxiety Agents	1	10
Bcl-2 protein down-regulation	2	10
Chemopreventive	8	10
Photoprotective	2	10
Gastroprotective	5	9
Nrf2 activation	5	9
Anti-Bacterial Agents	8	8
Antiviral Agents	6	8
Chemoprotective Agents	4	7
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	7
MicroRNA modulator	4	7
Anticarcinogenic Agents	4	6
Anticonvulsants	3	6
Immunomodulatory	5	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	6
Renoprotective	3	6
Antimalarials	4	5
Bax/Bcl2 ratio: Increase	1	5
Caspase-3 Activation	1	5
Caspase-9 Activation	1	5
Pancreato Protective Agents	3	5
Radioprotective	3	5
Tumor Suppressor Protein p53 Upregulation	1	5
Leishmanicidal	3	4
Prophylactic Agents	2	4
Transforming growth factor beta (TGF-β) inhibitor	3	4
Angiogenesis Inhibitors	3	3
Anticholesteremic Agents	2	3
Antifungal Agents	3	3
Antimicrobial	3	3
Antinoceceptive	1	3
Cytotoxic	1	3
Interleukin-10 upregulation	2	3
Multidrug Resistance Gene Modulators	3	3
Antidiarrheals	1	2
Antihypertensive Agents	1	2
Antimutagenic Agents	1	2
Brain-derived neurotrophic factor modulator	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Genoprotective	1	2
Heme oxygenase-1 up-regulation	1	2
Immunostimulatory	1	2
Immunosuppressive Agents	1	2
Insecticides	1	2
Interleukin-8 downregulation	2	2
Monoamine Oxidase Inhibitors	1	2
Neuritogenic	1	2
Radiosensitizer	2	2
Serotonergic	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-atherogenic	1	1
Anti-fungal effects	1	1
Antiparasitic Agents	1	1
Autophagy Up-regulation	1	1
Insecticidal	1	1
Insulin Sensitizers	1	1
Nitric Oxide Inhibitor	1	1
Prostaglandin PGE2 downregulation	1	1
STAT3 Activation	1	1
Survivin Down-Regulation	1	1
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

The effects of curcumin plus piperine co-administration on inflammation and oxidative stress.Mar 28, 2024

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Pubmed Data : Curr Med Chem. 2024 Mar 29. Epub 2024 Mar 29. PMID: 38561618

Article Published Date : Mar 28, 2024

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin, Piperine

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

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Pubmed Data : Asian Pac J Cancer Prev. 2022 Oct 1 ;23(10):3507-3515. Epub 2022 Oct 1. PMID: 36308377

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Click here to read the entire abstract

Pubmed Data : J Diet Suppl. 2018 Oct 9:1-12. Epub 2018 Oct 9. PMID: 30299203

Article Published Date : Oct 08, 2018

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Cadmium Poisoning

Pharmacological Actions : Antioxidants

Problem Substances : Cadmium

[+]

Curcumin, piperine and taurine combination enhances the efficacy of transarterial chemoembolization therapy.Apr 30, 2024

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Pharmacological Actions : Anti-Apoptotic, Antidepressive Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2014 Jul ;8(1):260-266. Epub 2014 May 16. PMID: 24944632

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : High Fat Diet, Hyperlipidemia, Triglycerides: Elevated

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

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Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Pubmed Data : Molecules. 2023 Jan 5 ;28(2). Epub 2023 Jan 5. PMID: 36677613

Article Published Date : Jan 04, 2023

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Immunosuppression by piperine as a regulator of the NLRP3 inflammasome.Jan 31, 2022

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Pubmed Data : Pharmaceutics. 2022 Aug 26 ;14(9). Epub 2022 Aug 26. PMID: 36145547

Article Published Date : Aug 25, 2022

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

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Pubmed Data : Iran J Basic Med Sci. 2017 Nov ;20(11):1227-1231. PMID: 29299200

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Kidney Damage, Lead Poisoning

Pharmacological Actions : Renoprotective

[+]

Piperine has the potential to be used as a bio-enhancing agent in combination with metformin.Dec 31, 2015

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Pubmed Data : Pharmacognosy Res. 2016 Jan-Mar;8(1):56-60. PMID: 26941537

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Bioenhancer, Medication Reduction, Natural Substance Synergy

[+]

Additional Keywords : Dose Response

[+]

[+]

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

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Protective effects of piperine on ethanol-induced gastric mucosa injury by oxidative stress inhibition.Nov 09, 2022

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Pubmed Data : Ann Med. 2021 Dec ;53(1):2009-2017. PMID: 34751064

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Piperine, Ursolic Acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Synergistic effects of curcumin and piperine in cocrystal form: a breakthrough in bladder cancer therapy.Apr 23, 2025

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Pubmed Data : J Biomater Sci Polym Ed. 2025 Apr 24:1-28. Epub 2025 Apr 24. PMID: 40270345

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance Synergy, Natural Substances Versus Drugs

[+]

Combinatorial therapeutic effect of resveratrol and piperine on murine model of systemic lupus erythematosus.Mar 31, 2020

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Pubmed Data : Inflammopharmacology. 2020 Apr ;28(2):401-424. Epub 2019 Nov 15. PMID: 31732838

Article Published Date : Mar 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine, Resveratrol

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor.May 31, 2020

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Pubmed Data : J Pharm Sci. 2024 Jul 14. Epub 2024 Jul 14. PMID: 39004416

Article Published Date : Jul 13, 2024

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Candida Albicans, Candida Glabrata

Pharmacological Actions : Antifungal Agents, Antimicrobial

[+]

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

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Pubmed Data : Antibiotics (Basel). 2019 May 4 ;8(2). Epub 2019 May 4. PMID: 31060239

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Pubmed Data : Clin Exp Pharmacol Physiol. 2023 Aug 21. Epub 2023 Aug 21. PMID: 37604463

Article Published Date : Aug 20, 2023

Study Type : Review

Additional Links

Substances : Piperine

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Gastrointestinal Agents

[+]

Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins.Mar 31, 2013

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Pubmed Data : J Nat Med. 2013 Apr ;67(2):303-10. Epub 2012 Jun 27. PMID: 22736065

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Pubmed Data : Front Pharmacol. 2023 ;14:1145666. Epub 2023 Apr 26. PMID: 37180710

Article Published Date : Dec 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Cannabinoids , Curcumin, Piperine

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Capsaicin and piperine can overcome multidrug resistance in cancer cells to doxorubicin.Mar 01, 2018

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Pubmed Data : Molecules. 2018 Mar 2 ;23(3). Epub 2018 Mar 2. PMID: 29498663

In vitro anti-parasitic effect of the alkaloids harmaline and piperine on Toxoplasma gondii.Dec 31, 2023

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Pubmed Data : Rev Bras Parasitol Vet. 2024 ;33(3):e001824. Epub 2024 Sep 16. PMID: 39292065

Article Published Date : Dec 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Piperine, Syrian rue

Diseases : Toxoplasma gondii Infection

Pharmacological Actions : Antiparasitic Agents

[+]

In vitro α- amylase and α- glucosidase enzyme inhibition and antioxidant activity by capsaicin and piperine from Capsicum chinense and Piper nigrum fruits.Jan 03, 2021

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Pubmed Data : J Environ Sci Health B. 2021 Jan 4:1-10. Epub 2021 Jan 4. PMID: 33397190

Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death.Jan 09, 2020

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Pubmed Data : J Pharm Pharmacol. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31922618

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Pubmed Data : Phytomedicine. 2018 Sep 28 ;54:98-108. Epub 2018 Sep 28. PMID: 30668388

Article Published Date : Sep 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperine, Silymarin

Additional Keywords : Food Bioavailability Enhancers

[+]

Piperine exhibits potential antibiofilm activity against Pseudomonas aeruginosa.Dec 28, 2022

Piperine increases pentagamavunon-1 anti-cancer activity on 4T1 breast cancer.Nov 30, 2022

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Pubmed Data : Iran J Pharm Res. 2022 Dec ;21(1):e123820. Epub 2022 Feb 4. PMID: 35765510

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Pubmed Data : Fungal Genet Biol. 2017 Aug 19. Epub 2017 Aug 19. PMID: 28830793

Article Published Date : Aug 18, 2017

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Aspergillosis

Pharmacological Actions : Antioxidants

Problem Substances : Aflatoxin

[+]

Piperine inhibits cell proliferation and induces apoptosis of human gastric cancer cells.Dec 30, 2020

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Piperine may become a potential therapeutic agent against bacterial sepsis.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2016 ;7:390. Epub 2016 Oct 20. PMID: 27812336

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Pubmed Data : Sci Rep. 2020 Jul 15 ;10(1):11681. Epub 2020 Jul 15. PMID: 32669593

Article Published Date : Jul 14, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation

[+]

Piperine synergistically enhances the effect of temozolomide against temozolomide-resistant human glioma cell lines.Jan 11, 2020

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Pubmed Data : Lett Appl Microbiol. 2022 Jan 3. Epub 2022 Jan 3. PMID: 34978719

Article Published Date : Jan 02, 2022

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Cholera, Escherichia coli Infections, Infection: Antibiotic Resistant, Pseudomonas aeruginosa

Pharmacological Actions : Anti-Bacterial Agents

[+]

Results suggest that piperine is a promising bio-pesticide agent for the control of R. ferrugineus Olivier.Mar 20, 2017

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Pubmed Data : Neotrop Entomol. 2017 Mar 21. Epub 2017 Mar 21. PMID: 28326461

Article Published Date : Mar 20, 2017

Study Type : Plant Study

Additional Links

Substances : Black Pepper, Piperine

Pharmacological Actions : Insecticidal

[+]

Resveratrol and piperine enhance radiosensitivity of tumor cells.Mar 31, 2012

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Pubmed Data : BMB Rep. 2012 Apr ;45(4):242-6. PMID: 22531135

Article Published Date : Mar 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Piperidines, Piperine, Resveratrol, Stilbenes

Diseases : Cancers: Radiation-Resistant, Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Radiosensitizer

[+]

The potential use of a curcumin-piperine combination as an antimalarial agent.Dec 31, 2020

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Pubmed Data : J Trop Med. 2021 ;2021:9135617. Epub 2021 Oct 11. PMID: 34671402

Article Published Date : Dec 31, 2020

Study Type : Review

Additional Links

Substances : Curcumin, Piperine

Diseases : Malaria

Pharmacological Actions : Anti-Inflammatory Agents, Antimalarials, Antioxidants

[+]

The present study provides useful insight into the apoptotic potential of piperine.Dec 31, 2018

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Pubmed Data : Semin Cancer Biol. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25865775

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Pubmed Data : BMC Complement Med Ther. 2023 Mar 4 ;23(1):69. Epub 2023 Mar 4. PMID: 36870998

Article Published Date : Mar 03, 2023

Study Type : In Vitro Study

Additional Links

Substances : Piperine, Thymoquinone

Diseases : Breast Cancer, Liver Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Chemothapeutic Synergy: Sorafenib

[+]

Piperine significantly enhances the bioavailability of EGCG in mice.Aug 01, 2004

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Pubmed Data : J Nutr. 2004 Aug;134(8):1948-52.C PMID: 15284381

Article Published Date : Aug 01, 2004

Additional Links

Substances : EGCG (Epigallocatechin gallate), Piperine

Additional Keywords : Increased Bioavailability

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The effects of curcumin plus piperine co-administration on inflammation and oxidative stress.Mar 28, 2024

Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

A standardized Withania somniferra root extract with piperine alleviates the symptoms of anxiety and depression.Oct 24, 2023

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

Curcumin appears to be a complementary treatment option for COVID-19 patients.Dec 31, 2022

Curcumin plus piperine improve body composition in patients with inflammatory bowel disease.Feb 10, 2025

Curcumin-piperine is effective in improving oxidative stress and reducing creatinine in diabetic retinopathy.Dec 31, 2023

Curcumin-piperine might synergise with vitamin D to induce clinical remission in patients with systemic lupus erythematosus.Jan 30, 2024

Curcumin-piperine supplementation can improve serum CRP, triglycerides, and glucose concentrations in patients with T2DM and hypertriglyceridemia.Oct 31, 2024

Curcuminoid-piperine combination improves radical scavenging activity in women with premenstrual syndrome and dysmenorrhea.Apr 30, 2024

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.Jan 02, 2018

Effect of curcumin plus Piperine on redox imbalance, fecal calprotectin and cytokine levels in inflammatory bowel disease patients.Jun 27, 2024

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19.Dec 31, 2020

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

Simultaneous use of narrowband ultraviolet B and topical piperine has a remarkable effect on treatment of vitiligo.May 20, 2018

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke.Dec 10, 2023

The result of the study demonstrates that NSO 250 mg with 2.5 mg piperine is an effective and well-tolerated supplement for the management of AR symptoms.Aug 08, 2024

The use of piperine-added Curcuma longa L. was effective in the glycaemic and TG control of patients with type 2 diabetes.Feb 13, 2021

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.Aug 31, 2019

Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis.Nov 19, 2022

Vitiligo treated with combined piperine-based topical treatment and narrowband ultraviolet B therapyFeb 24, 2024

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

Curcumin, piperine and taurine combination enhances the efficacy of transarterial chemoembolization therapy.Apr 30, 2024

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Alpha-mangostin, piperine and beta-sitosterol as hepatitis C antivirus.Aug 31, 2023

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain.Oct 22, 2022

Formulation of piperine nanoparticles: in vitro breast cancer cell line and in vivo evaluation.Mar 25, 2022

Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition.Nov 24, 2022

Piperine improves the sensitivity of osteosarcoma cells to doxorubicin.Mar 08, 2023

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.Jun 30, 2020

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination.Jul 14, 2020

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.May 31, 2020

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.Jan 01, 2010

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes.Feb 14, 2024

Antioxidant effects of piperine in in-vivo cataract model induced by steroids.Feb 28, 2019

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Black Pepper reduces high-fat diet induced oxidative stress.Jan 01, 2004

Black pepper shows potential as a larvicide for the control of certain malaria vector species.Dec 31, 2015

Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.Dec 31, 2012

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.Dec 31, 2019

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own. Jul 25, 2015

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.Jul 02, 2015

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.Sep 13, 2011

Dietary piperine suppresses obesity-associated breast cancer growth and metastasis.Dec 28, 2021

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.Feb 24, 2010

Enhanced in vivo wound healing efficacy of a novel piperine-containing bioactive hydrogel.Jan 04, 2023

Immunosuppression by piperine as a regulator of the NLRP3 inflammasome.Jan 31, 2022

Nanoemulsion-based piperine to enhance bioavailability for the treatment of LPS-induced depression-like behaviour.Sep 24, 2023

Natural piperine improves lipid metabolic profile of high-fat diet-fed mice.Feb 25, 2021

Neuroprotective effect of quercetin in combination with piperine against rotenone-and iron supplement-induced Parkinson's disease.Oct 24, 2019

Oral administration of Curcuma longa associated with white pepper at doses that can be extrapolated to human exposure upon supplementation improves pro-inflammatory disorders.Dec 31, 2012

P. nigrum is a source of potent and safe antileishmanial compounds.Dec 31, 2014

Piperine alleviates doxorubicin-induced cardiotoxicity.Dec 31, 2018

Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.Nov 30, 2018

Piperine ameliorated the progression of TNBS-induced colitis.Dec 12, 2019

Piperine ameliorates ischemic stroke-induced brain injury.Sep 14, 2022

Piperine ameliorates trimellitic anhydride-induced atopic dermatitis-like symptoms.May 06, 2020

Piperine and Curcumin (from Turmeric) attenuates Cadmium induced immunotoxicity.Dec 01, 2008

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View the Evidence:
265 Abstracts with Piperine Research