Piperine

Name	AC	CK
Diabetes Mellitus: Type 2	5	26
Oxidative Stress	6	19
Fibrosis	2	12
Vitiligo	2	12
Alzheimer's Disease	7	10
High Fat Diet	5	10
Metabolic Diseases	1	10
Muscle Damage: Exercise-Induced	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Ultraviolet Radiation Induced Damage	2	10
Lung Cancer	4	9
Depression	4	8
Lipopolysaccharide-Induced Toxicity	5	8
Obesity	4	8
Parkinson's Disease	5	8
Cadmium Poisoning	2	7
Inflammation	5	7
Cancers: All	6	6
Cervical Cancer	2	6
Cognitive Decline/Dysfunction	3	6
Brain Inflammation	3	5
Colorectal Cancer	4	5
Osteosarcoma	1	5
Breast Cancer	4	4
Cerebral Ischemia	2	4
Colon Cancer	4	4
Diabetes: Cognitive Dysfunction	2	4
Epilepsy	2	4
Kidney Damage	2	4
Liver Cancer	3	4
Staphylococcus aureus infection	3	4
Breast Cancer: Triple Negative	3	3
Candida Albicans	3	3
Helicobacter Pylori Infection	2	3
Leishmaniasis	2	3
Myocardial Fibrosis	2	3
Neurodegenerative Diseases	2	3
Pancreatitis	2	3
Triglycerides: Elevated	2	3
Atopic Dermatitis	1	2
Bacterial Infections	1	2
Cataract	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chronic Myeloid Leukemia	2	2
Colitis	1	2
Copper Toxicity	1	2
Coronavirus Infection	2	2
DNA damage	1	2
Depressive Disorder	1	2
Diabetic Complications	1	2
Encephalomyelitis	1	2
Endometritis	1	2
Endotoxemia	1	2
Epilepsy: Drug-Induced	1	2
Escherichia coli Infections	2	2
Fat Malabsorption	1	2
Gallstones	1	2
Gastritis	1	2
HPA Axis Dysregulation	1	2
Hyperlipidemia	1	2
Indigestion: Fats	1	2
Inflammatory Bowel Diseases	1	2
Insulin Resistance	1	2
Ischemia	1	2
Lead Poisoning	1	2
Leptin Resistance	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Lupus Nephritis	1	2
Lupus-Like Syndrome	1	2
Malabsorption Syndrome	1	2
Mastitis	1	2
Memory Disorders	1	2
Metabolic Syndrome X	1	2
Microvilli atrophy	1	2
Multiple Sclerosis	1	2
Myelotoxicity	1	2
Myocardial Ischemia	1	2
Ovarian Cancer	2	2
Periodontitis	1	2
Prostate Cancer	2	2
Sepsis	2	2
Steatorrhea	1	2
Stress	1	2
Aspergillosis	1	1
Atherosclerosis	1	1
Autism	1	1
Autoimmune Diseases	1	1
Cancer Stem Cells	1	1
Cancers: Drug Resistant	1	1
Cancers: Radiation-Resistant	1	1
Dental Implantation	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Gastric Cancer	1	1
Glioma	1	1
High Cholesterol	1	1
Huntington Disease	1	1
Hyperglycemia	1	1
Malaria	1	1
Oral Cancer	1	1
Organ Transplantation	1	1
Osteoclastoma	1	1
Pseudomonas aeruginosa	1	1
Radiation	1	1
Seizures	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Systemic Lupus Erythematosus	1	1
Thyroid Cancer	1	1
Traumatic Brain Injury	1	1

Name	AC	CK
Anti-Inflammatory Agents	30	58
Antioxidants	21	46
Neuroprotective Agents	24	42
Antiproliferative	20	26
Apoptotic	19	26
Cell cycle arrest	8	17
Hepatoprotective	4	16
Tumor Necrosis Factor (TNF) Alpha Inhibitor	10	16
Hypoglycemic Agents	4	15
Interleukin-1 beta downregulation	9	15
Hypolipidemic	3	14
Anti-Fibrotic	3	13
Cardioprotective	7	13
NF-kappaB Inhibitor	8	13
Anti-metastatic	8	12
Adiponectin upregulation	1	10
Antidepressive Agents	5	10
Bcl-2 protein down-regulation	2	10
Photoprotective	2	10
Anti-Apoptotic	5	8
Chemopreventive	6	8
Chemosensitizer	4	8
Interleukin-6 Downregulation	5	8
Anticonvulsants	3	6
Chemotherapeutic	4	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	6
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	6
Anticarcinogenic Agents	3	5
Bax/Bcl2 ratio: Increase	1	5
Caspase-3 Activation	1	5
Caspase-9 Activation	1	5
Pancreato Protective Agents	3	5
Tumor Suppressor Protein p53 Upregulation	1	5
Chemoprotective Agents	2	4
Immunomodulatory	3	4
Renoprotective	2	4
Anticholesteremic Agents	2	3
Gastroprotective	2	3
Leishmanicidal	2	3
Multidrug Resistance Gene Modulators	3	3
Angiogenesis Inhibitors	2	2
Anti-Bacterial Agents	2	2
Antihypertensive Agents	1	2
Antimicrobial	2	2
Antimutagenic Agents	1	2
Antiviral Agents	2	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Genoprotective	1	2
Immunostimulatory	1	2
Insecticides	1	2
Monoamine Oxidase Inhibitors	1	2
Prophylactic Agents	1	2
Serotonergic	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-atherogenic	1	1
Antimalarials	1	1
Cyclooxygenase 2 Inhibitors	1	1
Insecticidal	1	1
Interleukin-8 downregulation	1	1
MicroRNA modulator	1	1
Nitric Oxide Inhibitor	1	1
Nrf2 activation	1	1
Prostaglandin PGE2 downregulation	1	1
Radioprotective	1	1
Radiosensitizer	1	1
STAT3 Activation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2022 Oct 1 ;23(10):3507-3515. Epub 2022 Oct 1. PMID: 36308377

Article Published Date : Sep 30, 2022

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative

Additional Keywords : Cancer Stem Cells

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Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

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Pubmed Data : Front Pharmacol. 2021 ;12:669362. Epub 2021 May 28. PMID: 34122090

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Coronavirus Infection

Additional Keywords : Morbidity, Mortality, Risk Reduction

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Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

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Pubmed Data : Clin Nutr. 2015 Jan 7. Epub 2015 Jan 7. PMID: 25618800

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

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Pubmed Data : Int Immunopharmacol. 2015 Jan ;24(1):50-8. Epub 2014 Nov 20. PMID: 25479727

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

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Substances : Piperine

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

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Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201

Article Published Date : Mar 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Cytotoxicity

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Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain.Oct 22, 2022

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Pubmed Data : Chin Med. 2022 Oct 23 ;17(1):119. Epub 2022 Oct 23. PMID: 36274168

Article Published Date : Oct 22, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Chronic Pain

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive

Additional Keywords : Natural Substance Synergy

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Formulation of piperine nanoparticles: in vitro breast cancer cell line and in vivo evaluation.Mar 25, 2022

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Pubmed Data : Cutan Ocul Toxicol. 2019 Mar 1:1-8. Epub 2019 Mar 1. PMID: 30678496

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Cataract

Pharmacological Actions : Antioxidants

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Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

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Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

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Pubmed Data : Exp Ther Med. 2014 Jul ;8(1):260-266. Epub 2014 May 16. PMID: 24944632

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : High Fat Diet, Hyperlipidemia, Triglycerides: Elevated

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

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Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

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Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

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Pubmed Data : Pharmaceutics. 2022 Aug 26 ;14(9). Epub 2022 Aug 26. PMID: 36145547

Article Published Date : Aug 25, 2022

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

[+]

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

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Additional Keywords : Natural Substance Synergy

[+]

Systemic administration of curcumin or piperine enhances the periodontal repair.Nov 28, 2018

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Pubmed Data : Clin Oral Investig. 2018 Nov 29. Epub 2018 Nov 29. PMID: 30498979

Article Published Date : Nov 28, 2018

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Periodontitis

Additional Keywords : Bodily Tissue Regeneration, Bone Regeneration

[+]

The anticonvulsant effects of piperine ameliorate memory impairment, inflammation and oxidative stress in a rat model of pilocarpine-induced epilepsy.Jan 31, 2017

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Pubmed Data : Exp Ther Med. 2017 Feb ;13(2):695-700. Epub 2016 Dec 27. PMID: 28352353

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Epilepsy: Drug-Induced

Pharmacological Actions : Anticonvulsants, Antioxidants

[+]

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance Synergy, Natural Substances Versus Drugs

[+]

Combinatorial therapeutic effect of resveratrol and piperine on murine model of systemic lupus erythematosus.Mar 31, 2020

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Pubmed Data : Inflammopharmacology. 2020 Apr ;28(2):401-424. Epub 2019 Nov 15. PMID: 31732838

Article Published Date : Mar 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine, Resveratrol

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:6288742. Epub 2022 May 12. PMID: 35600948

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Cholangiocarcinoma

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Herbal-based nano systems have promising proficiency in treatment of neurodegenerative disorders.Dec 31, 2019

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Pubmed Data : Comput Biol Med. 2021 Aug 28 ;137:104818. Epub 2021 Aug 28. PMID: 34481181

Article Published Date : Aug 27, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

In this review, they have summarized the recent progress on dietary nutraceuticals in reversing multidrug resistance.Dec 31, 2014

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(16):6831-9. PMID: 26514453

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : beta-Carotene, Bitter Melon, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Fruit: All, Fucoxanthin , Gingerol , Grape Seed Extract, Indole-3-Carbinol, Piperine, Quercetin, Resveratrol, Vegetables: All

Diseases : Cancers: All

Pharmacological Actions : Multidrug Resistance Gene Modulators

Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy

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Oxidative stress induced by piperine leads to apoptosis in Candida albicans.Jul 12, 2020

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Pubmed Data : Med Mycol. 2020 Jul 13. Epub 2020 Jul 13. PMID: 32658959

Article Published Date : Jul 12, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Candida Albicans

Pharmacological Actions : Anti-Bacterial Agents, Apoptotic

[+]

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Pubmed Data : Biotechnol Lett. 2020 Jun 4. Epub 2020 Jun 4. PMID: 32500474

Article Published Date : Jun 03, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, STAT3 Activation

[+]

Piperine derived from Piper nigrum L. inhibits LPS-induced inflammation.Sep 25, 2022

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Pubmed Data : Arch Microbiol. 2021 Dec 23 ;204(1):59. Epub 2021 Dec 23. PMID: 34940904

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Pubmed Data : Pharm Biol. 2022 Dec ;60(1):96-107. PMID: 34962450

Article Published Date : Nov 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

The influence of piperine on the radioprotective effect of curcumin in irradiated human lymphocytes.Aug 31, 2019

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Pubmed Data : Iran J Public Health. 2021 May ;50(5):1037-1047. PMID: 34183962

Article Published Date : Apr 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

The use of phytochemicals may be a true therapeutic strategy for eradicating cancer through the elimination of CSCs.Dec 31, 2014

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Pubmed Data : Int J Mol Sci. 2015 ;16(7):15727-42. Epub 2015 Jul 10. PMID: 26184171

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Pubmed Data : Semin Cancer Biol. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25865775

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Pubmed Data : J Nutr. 2004 Aug;134(8):1948-52.C PMID: 15284381

Article Published Date : Aug 01, 2004

Additional Links

Substances : EGCG (Epigallocatechin gallate), Piperine

Additional Keywords : Increased Bioavailability

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View the Evidence: 201 Abstracts with Piperine Research

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Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.Jan 02, 2018

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19.Dec 31, 2020

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

Simultaneous use of narrowband ultraviolet B and topical piperine has a remarkable effect on treatment of vitiligo.May 20, 2018

The use of piperine-added Curcuma longa L. was effective in the glycaemic and TG control of patients with type 2 diabetes.Feb 13, 2021

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.Aug 31, 2019

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain.Oct 22, 2022

Formulation of piperine nanoparticles: in vitro breast cancer cell line and in vivo evaluation.Mar 25, 2022

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.Jun 30, 2020

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination.Jul 14, 2020

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.May 31, 2020

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.Jan 01, 2010

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

Antioxidant effects of piperine in in-vivo cataract model induced by steroids.Feb 28, 2019

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Black Pepper reduces high-fat diet induced oxidative stress.Jan 01, 2004

Black pepper shows potential as a larvicide for the control of certain malaria vector species.Dec 31, 2015

Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.Dec 31, 2012

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.Dec 31, 2019

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own. Jul 25, 2015

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.Jul 02, 2015

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.Sep 13, 2011

Dietary piperine suppresses obesity-associated breast cancer growth and metastasis.Dec 28, 2021

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.Feb 24, 2010

Immunosuppression by piperine as a regulator of the NLRP3 inflammasome.Jan 31, 2022

Natural piperine improves lipid metabolic profile of high-fat diet-fed mice.Feb 25, 2021

Neuroprotective effect of quercetin in combination with piperine against rotenone-and iron supplement-induced Parkinson's disease.Oct 24, 2019

Oral administration of Curcuma longa associated with white pepper at doses that can be extrapolated to human exposure upon supplementation improves pro-inflammatory disorders.Dec 31, 2012

P. nigrum is a source of potent and safe antileishmanial compounds.Dec 31, 2014

Piperine alleviates doxorubicin-induced cardiotoxicity.Dec 31, 2018

Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.Nov 30, 2018

Piperine ameliorated the progression of TNBS-induced colitis.Dec 12, 2019

Piperine ameliorates ischemic stroke-induced brain injury.Sep 14, 2022

Piperine ameliorates trimellitic anhydride-induced atopic dermatitis-like symptoms.May 06, 2020

Piperine and Curcumin (from Turmeric) attenuates Cadmium induced immunotoxicity.Dec 01, 2008

Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.Oct 31, 2019

Piperine as therapeutic agent in paracetamol-induced hepatotoxicity.Aug 25, 2022

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease.Jul 31, 2019

Piperine can be considered as an effective bioactive molecule to suppress of body weight, improve insulin and leptin sensitivity, and regulating obesity.Sep 24, 2014

Piperine can relieve depression in rats by modulating the function of HPA axis.Jul 01, 2009

Piperine enhanced the bioavailability of curcumin and potentiated its protective effects against CUS induced cognitive impairment and associated oxidative damage in mice.Dec 06, 2012

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

Piperine enhances the antimalarial activity of curcumin in Plasmodium berghei.Dec 31, 2021

Piperine enhances the antioxidant and anti-Inflammatory activities of thymoquinone against microcystin-LR-induced hepatotoxicity and neurotoxicity.Dec 31, 2018

Piperine enhances the protective effect of curcumin against 3-Nitropropionic acid induced neurotoxicity.Jul 31, 2015

Piperine has a blood pressure lowering and vasomodulator effect.Nov 01, 2008

Piperine has anticonvulsant effects in-vivo and in-vitro.Sep 02, 2015

Piperine has protective effects on lead acetate induced-nephrotoxicity in rats.Oct 31, 2017

Piperine has the potential to be used as a bio-enhancing agent in combination with metformin.Dec 31, 2015

Piperine improves obesity by inhibiting fatty acid absorption and repairing intestinal barrier function.Sep 29, 2021

Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration.Oct 18, 2017

Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis.Nov 14, 2021

Piperine may be a potential anti-inflammatory treatment both in endometritis and in other S. aureus-induced diseases.Dec 31, 2015

Piperine may be a promising prooxidant drug for the amelioration of hepatocellular carcinoma.Mar 20, 2017

Piperine may be used as a bioenhancer to improve pharmacological effect of ginsenoside Rh2 when given orally.Jan 31, 2018

Piperine

View the Evidence:
201 Abstracts with Piperine Research