Piperlongumine

Name	AC	CK
Cancers: All	9	12
Breast Cancer	8	9
Liver Cancer	7	9
Lung Cancer	8	9
Colon Cancer	6	8
Inflammation	5	8
Breast Cancer: Triple Negative	5	7
Cancers: Drug Resistant	6	7
Retinoblastoma	3	7
Colorectal Cancer	5	6
Gastric Cancer	3	6
Lipopolysaccharide-Induced Toxicity	3	6
Oxidative Stress	4	6
Carcinoma: Non-Small-Cell Lung	4	5
Glioblastoma	3	5
Lung Damage	3	5
Cholangiocarcinoma	4	4
Oral Cancer	3	4
Osteoarthritis	2	4
Pancreatic Cancer	3	4
Alzheimer's Disease	2	3
Head and Neck Cancer	2	3
Lung Inflammation	2	3
Myocardial Fibrosis	2	3
Osteosarcoma	3	3
Prostate Cancer	3	3
Squamous cell carcinoma	2	3
Thyroid Cancer	2	3
Bladder Cancer	2	2
Cancers: Radiation-Resistant	1	2
Cardiac Hypertrophy	1	2
Cerebral Ischemia	1	2
Cervical Cancer	2	2
Chemotherapy and Radiation Toxicity	1	2
Chronic Pain	1	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Depression	1	2
Endotoxemia	1	2
Hyperglycemia	1	2
Ischemia	1	2
Kidney Damage	1	2
Kidney Fibrosis	1	2
Liver Fibrosis	1	2
Multiple Myeloma	1	2
Multiple Sclerosis	1	2
Mycobacterium Tuberculosis	1	2
Neuroblastoma	1	2
Ovarian Cancer	1	2
Pancreatitis	1	2
Parkinson's Disease	1	2
Pheochromocytoma	1	2
Schistosomiasis	1	2
Sepsis	1	2
Titanium Toxicity	1	2
Acute Myeloid Leukemia	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Arterial Calcification	1	1
Asthma	1	1
Atherosclerosis	1	1
Cancer Metastasis	1	1
Candida Albicans	1	1
Chronic Obstructive Pulmonary Disease	1	1
Gallbladder Cancer	1	1
Hypertension: Pulmonary	1	1
Intestinal Cancer	1	1
Kidney Cancer	1	1
Leishmaniasis	1	1
Leukemia	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Lung Injury: Smoke-Induced	1	1
Malignant Melanoma	1	1
Melanoma	1	1
Myocardial Ischemia	1	1
Neurodegenerative Diseases	1	1
Pseudomonas aeruginosa	1	1
Psoriasis	1	1
Rheumatoid Arthritis	1	1
Staphylococcus aureus infection	1	1
Uveitis	1	1
Zika Virus	1	1

Name	AC	CK
Antiproliferative	39	51
Apoptotic	39	51
Anti-Inflammatory Agents	20	33
Anti-metastatic	14	18
NF-kappaB Inhibitor	11	18
Chemosensitizer	15	17
Cell cycle arrest	11	13
Chemotherapeutic	11	12
Antioxidants	6	10
Interleukin-6 Downregulation	5	8
Anti-Fibrotic	4	7
Chemopreventive	4	7
STAT3 Inhibitor	5	7
Interleukin-1 beta downregulation	3	6
Antineoplastic Agents	5	5
Cyclooxygenase 2 Inhibitors	4	5
Multidrug Resistance Gene Modulators	1	5
Neuroprotective Agents	3	5
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	5
Anti-Apoptotic	2	4
Autophagy Up-regulation	4	4
Cardioprotective	3	4
Cytotoxic	3	4
Renoprotective	2	4
Immunomodulatory	2	3
Radiosensitizer	2	3
Tumor Suppressor Protein p53 Upregulation	2	3
Analgesics	1	2
Angiogenesis Inhibitors	1	2
Anti-Tumor	1	2
Antidepressive Agents	1	2
Antiparasitic Agents	1	2
Chemoprotective Agents	1	2
Chondroprotective	1	2
Cyclin D1 Down-Regulation	1	2
Hepatoprotective	1	2
MicroRNA modulator	2	2
Osteoprotective	1	2
Radioprotective	1	2
Transforming growth factor beta (TGF-β) inhibitor	1	2
Vasoprotective	2	2
Wnt/β-catenin signaling pathway modulation	2	2
Acetylcholinesterase Inhibitor	1	1
Anti-Asthmatic Agents	1	1
Anticarcinogenic Agents	1	1
Antimicrobial	1	1
Antiviral Agents	1	1
Bcl-2 protein down-regulation	1	1
Caspase-3 Activation	1	1
E-cadherin down-regulation	1	1
Heme oxygenase-1 up-regulation	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Immunomodulatory: Th17 downregulation	1	1
Immunosuppressive Agents	1	1
Leishmanicidal	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
P21 Activation	1	1
Survivin Down-Regulation	1	1
TRAIL sensitizer	1	1

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Piperlongumine could reverse chemotherapy resistance of retinoblastoma cancer cells in a dose-dependent manner. Dec 31, 2014

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Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(3):2525-34. Epub 2015 Mar 1. PMID: 26045758

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

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Substances : Piperlongumine

Diseases : Retinoblastoma

Pharmacological Actions : Multidrug Resistance Gene Modulators

Additional Keywords : Dose Response

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Allosteric antagonist modulation of TRPV2 by piperlongumine impairs glioblastoma progression.May 25, 2021

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Pubmed Data : ACS Cent Sci. 2021 May 26 ;7(5):868-881. Epub 2021 Apr 14. PMID: 34079902

Article Published Date : May 25, 2021

Study Type : Animal Study

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Substances : Piperlongumine

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative

[+]

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Pubmed Data : Oncotarget. 2016 May 26. Epub 2016 May 26. PMID: 27244895

Article Published Date : May 25, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Piperlongumine

Diseases : Cancers: All, Liver Cancer, Neuroblastoma, Pheochromocytoma

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Selective Cytotoxicity

[+]

Piperlongumine as a neuro-protectant in chemotherapy induced cognitive impairment.Feb 10, 2022

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Pubmed Data : J Exp Clin Cancer Res. 2023 May 10 ;42(1):118. Epub 2023 May 10. PMID: 37161450

Article Published Date : May 09, 2023

Study Type : Animal Study

Additional Links

Substances : Piperlongumine

Diseases : Cancers: Drug Resistant, Cancers: Radiation-Resistant, Glioblastoma, Oxidative Stress

Pharmacological Actions : Chemosensitizer, Immunomodulatory, Radiosensitizer

Additional Keywords : Tumor Microenvironment

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Piperlongumine could be used to overcome bortezomib resistance in multiple myeloma.Nov 07, 2016

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Pubmed Data : Neuromolecular Med. 2018 May 25. Epub 2018 May 25. PMID: 29802525

Article Published Date : May 24, 2018

Study Type : Animal Study

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Substances : Piperlongumine

Diseases : Alzheimer's Disease, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

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Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1462-1477. Epub 2018 Nov 13. PMID: 30551398

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Piperlongumine

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

[+]

Piperlongumine may serve as an effective therapeutic agent for oral cancer.Jan 31, 2018

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Pubmed Data : Biomed Pharmacother. 2020 Aug ;128:110243. Epub 2020 May 27. PMID: 32470748

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Pubmed Data : Sci Rep. 2015 ;5:9987. Epub 2015 May 18. PMID: 25984950

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Breast Cancer: Triple Negative , Colon Cancer, Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, TRAIL sensitizer

Additional Keywords : Natural Substance Synergy

[+]

Piperlongumine attenuates high calcium/phosphate-induced arterial calcification.Dec 31, 2019

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Pubmed Data : J Ethnopharmacol. 2022 Oct 8 ;301:115815. Epub 2022 Oct 8. PMID: 36220508

Pubmed Data : Life Sci. 2022 Nov 15 ;309:121023. Epub 2022 Oct 4. PMID: 36202175

Article Published Date : Nov 14, 2022

Study Type : In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Cancers: Drug Resistant, Glioblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Piperlongumine: the amazing amide alkaloid from Piper in the treatment of breast cancer.Nov 12, 2023

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov 13. Epub 2023 Nov 13. PMID: 37955690

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Pubmed Data : Chem Biol Interact. 2019 Feb 25 ;300:40-48. Epub 2019 Jan 3. PMID: 30611789

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Pubmed Data : Cell Death Dis. 2019 Aug 8 ;10(8):600. Epub 2019 Aug 8. PMID: 31395855

View the Evidence: 123 Abstracts with Piperlongumine Research

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Piperlongumine could reverse chemotherapy resistance of retinoblastoma cancer cells in a dose-dependent manner. Dec 31, 2014

Allosteric antagonist modulation of TRPV2 by piperlongumine impairs glioblastoma progression.May 25, 2021

Antiparasitic activity of piplartine in a mouse model of schistosomiasis.Jan 17, 2020

Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.Sep 14, 2015

Effects of piperlonguminine on lung injury in severe acute pancreatitis. Mar 19, 2023

Low-dose piperlongumine rescues impaired function of endothelial progenitor cells and reduces cerebral ischemic injury.Dec 31, 2020

Piperlongumin improves survival in the mouse model of sepsis.Jul 12, 2022

Piperlongumine a promising potential candidate for use as a therapeutic option for patients with PHEO/PGL and SDHB mutations.May 25, 2016

Piperlongumine as a neuro-protectant in chemotherapy induced cognitive impairment.Feb 10, 2022

Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis.Jan 31, 2021

Piperlongumine attenuates bile duct ligation-induced liver fibrosis.Oct 31, 2020

Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetes.Mar 15, 2021

Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer.Mar 31, 2022

Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma.May 09, 2023

Piperlongumine could be used to overcome bortezomib resistance in multiple myeloma.Nov 07, 2016

Piperlongumine could be useful for the treatment for multiple sclerosis.Jan 31, 2017

Piperlongumine could inhibit lung cancer cell growth via inhibition of NF-κB signaling pathway in vitro and in vivo.Dec 31, 2015

Piperlongumine demonstrates potential for the treatment of Alzheimer's disease.May 24, 2018

Piperlongumine exhibits antitumor activity and has the potential for use as a chemotherapeutic agent against thyroid cancer.Aug 23, 2021

Piperlongumine has the potential to treat osteoclast-related diseases.Mar 04, 2022

Piperlongumine induces apoptosis and synergizes with doxorubicin in triple-negative breast cancer.Jun 24, 2019

Piperlongumine inhibits diethylnitrosamine induced hepatocellular carcinoma in rats.Dec 31, 2021

Piperlongumine inhibits head and neck squamous cell carcinoma proliferation by docking to Akt.Aug 14, 2020

Piperlongumine is an NLRP3 inhibitor with anti-inflammatory activity. Dec 31, 2020

Piperlongumine may be an effective chemopreventive agent for colon cancer.Dec 31, 2018

Piperlongumine may serve as an effective therapeutic agent for oral cancer.Jan 31, 2018

Piperlongumine mediates amelioration of osteoarthritis.Nov 07, 2023

Piperlongumine mitigates LPS-induced inflammation and lung injury.Jan 28, 2023

Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells.Sep 05, 2019

Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models.Feb 12, 2018

Piperlongumine restores the balance of autophagy and apoptosis in rotenone-induced Parkinson disease models.Feb 12, 2018

Piperlongumine was a direct STAT3 inhibitor and caused regression of breast cancer cell line xenografts in nude mice.Mar 30, 2014

Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells.Apr 30, 2019

Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6.Sep 14, 2023

Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain.Sep 30, 2016

Protective effect of piperlongumine on inflammation and oxidative stress against kidney ischemia-reperfusion.Dec 31, 2021

Protein regulator of cytokinesis 1 is a novel downstream target of piperlongumine in gastric cancer.Jun 30, 2017

Regular consumption of piperlongumine can be an effective approach in the prevention of colon cancer in humans.Mar 31, 2021

Repression of hexokinases II-mediated glycolysis contributes to piperlongumine-induced tumor suppression in non-small cell lung ccancer cells.Dec 31, 2018

Survivin promotes piperlongumine resistance in ovarian cancer. Dec 31, 2018

The present study demonstrated that piperlongumine exhibits the antidepressant-like effects.Sep 08, 2019

The protective action of piperlongumine against mycobacterial pulmonary tuberculosis.Nov 30, 2021

These data suggested that piperlongumine might be an effective agent in treating colitis and colorectal cancer.Dec 31, 2019

Enhancement of piperlongumine chemosensitivity by silencing heme oxygenase-1 expression in cholangiocarcinoma cell lines.Aug 31, 2020

Piperlongumine increases the apoptotic effect of doxorubicin and paclitaxel in a cervical cancer cell line.Feb 29, 2020

Piperlongumine induces cellular apoptosis and autophagy via the ROS/Akt signaling pathway in human follicular thyroid cancer cells.Apr 27, 2023

Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells.Jul 31, 2020

Piperlonguminine a new mitochondrial aldehyde dehydrogenase activator protects the heart from ischemia/reperfusion injury.Oct 31, 2020

Synergistic effects of piperlongumine and gemcitabine against KRAS mutant lung cancer.Jun 08, 2020

A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing.Jun 30, 2021

A review of targeting oncogenic transcription factors by polyphenols.Jan 03, 2018

A review of the role of phytochemicals in cancer prevention.Oct 08, 2019

Annexin A1 mimetic peptide and piperlongumine: anti-inflammatory profiles in endotoxin-induced uveitis.Jan 14, 2021

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

CD133 increases oxidative glucose metabolism of HT29 cancer cells by mitochondrial uncoupling and its inhibition enhances reactive oxygen species-inducing therapy.May 29, 2022

Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells.Oct 12, 2023

Combining an autophagy inhibitor with piperlongumine treatment can exert effective anticancer properties in oral cancer cells.Aug 31, 2023

Downregulation of FHOD1 inhibits metastatic potential in A549 cells. Dec 31, 2020

Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury.Jan 23, 2020

Harmine and piperlongumine revert TRIB2-mediated drug resistance.Dec 08, 2020

Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2.Jan 14, 2021

Increased expression of FosB through reactive oxygen species accumulation functions as pro-apoptotic protein in piperlongumine treated MCF7 breast cancer cells.Dec 30, 2019

Molecular docking analysis of piperlongumine with different apoptotic proteins involved in Hepatocellular Carcinoma.Dec 31, 2020

Network pharmacology-based anti-colorectal cancer activity of piperlonguminine in the ethanolic root extract of Piper longum.Oct 04, 2023

Parthenolide or piperlongumine that induce almost complete glutathione depletion and severe cell death in AML cells.Nov 21, 2013

Piperlongumine analogs promote A549 cell apoptosis through enhancing ROS generation.May 27, 2021

Piperlongumine and alpha lipoic acid may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.Mar 31, 2016

Piperlongumine and analogues could be beneficial in breast cancer treatment.Jan 04, 2017

Piperlongumine and bortezomib synergically inhibit cholangiocarcinoma.Oct 12, 2022

Piperlongumine and immune cytokine TRAIL synergize to promote tumor death.Dec 31, 2014

Piperlongumine attenuates high calcium/phosphate-induced arterial calcification.Dec 31, 2019

Piperlongumine attenuates vascular remodeling in hypoxic pulmonary hypertension by regulating autophagy.Dec 31, 2021

Piperlongumine

View the Evidence:
123 Abstracts with Piperlongumine Research