Polyunsaturated Fatty Acids (PUFAs)

Views 1714
Download the GMI DOC on this Topic

Sign in to Purchase/Download Documents

Sign in / Register

Focus Your Research

Click any topic below to filter + focus research
71 Diseases Researched for Polyunsaturated Fatty Acids (PUFAs)
NameACCKFocus
Depression636Locked
Nonalcoholic fatty liver disease (NAFLD)230Locked
Alzheimer's Disease523Locked
Hypertension221Locked
Asthma220Locked
Childhood Cognitive Disorders120Locked
Cognitive Decline/Dysfunction220Locked
Hepatic Steatosis120Locked
Insulin Resistance120Locked
Obesity516Locked
Cardiovascular Diseases413Locked
Inflammation1013Locked
Aging212Locked
Cardiovascular Disease: Prevention211Locked
All-Cause Mortality110Locked
Amyotrophic Lateral Sclerosis110Locked
Apraxias110Locked
Autism Spectrum Disorders110Locked
Barrett Esophagus110Locked
COPD110Locked
Cerebrovascular Disorders110Locked
Coronary Bypass Surgery110Locked
Coronavirus Disease (Covid-19)110Locked
Coronavirus Infection110Locked
Diabetic Retinopathy110Locked
Dry Eye Syndromes110Locked
Esophageal Cancer110Locked
Fatigue110Locked
Hypercholesterolemia110Locked
Lung Cancer110Locked
Schizophrenia110Locked
Smoking110Locked
Wheezing: Infants110Locked
Brain Inflammation 35Locked
Aneurysm: Aortic24Locked
High Fat Diet24Locked
Multiple Sclerosis34Locked
Autoimmune Diseases33Locked
Colorectal Cancer23Locked
Lipopolysaccharide-Induced Toxicity23Locked
Aging: Brain 12Locked
Air Pollution Linked Toxicity12Locked
Breast Cancer22Locked
Cancers: All22Locked
Demyelinating Diseases12Locked
Diabetes Mellitus: Type 122Locked
Diabetes Mellitus: Type 2: Prevention12Locked
Endometrial Cancer12Locked
HIV Infections12Locked
Hepatitis B 12Locked
Hepatitis C12Locked
Liver Fibrosis12Locked
Memory Disorders12Locked
Metabolic Diseases12Locked
Neurodegenerative Diseases22Locked
Neurologic Disorders12Locked
Oxidative Stress12Locked
Parkinson's Disease22Locked
Testicular Cancer12Locked
Tumors12Locked
Colitis11Locked
Colon Cancer11Locked
Colorectal Cancer: Prevention 11Locked
Encephalomyelitis11Locked
Endocannabinoid Disorders11Locked
Glioblastoma11Locked
Hyperlipidemia11Locked
Osteoporosis11Locked
Polycystic Ovary Syndrome11Locked
Rheumatoid Arthritis11Locked
Systemic Lupus Erythematosus11Locked
45 Pharmacological Actions Researched for Polyunsaturated Fatty Acids (PUFAs)
NameACCKFocus
Hepatoprotective434Locked
Antihypertensive Agents331Locked
Anti-Inflammatory Agents1722Locked
Antioxidants619Locked
Immunomodulatory717Locked
Chemopreventive415Locked
Cardioprotective312Locked
Hypolipidemic312Locked
Glucagon Like peptide 1 (GLP-1) Up-regulation211Locked
Anti-Asthmatic Agents110Locked
Anticholesteremic Agents110Locked
Antiviral Agents110Locked
Cardiovascular Agents110Locked
Cholecystokinin (CCK) Up-regulation110Locked
Ghrelin Down-Regulation110Locked
Apoptotic46Locked
Antidepressive Agents35Locked
Anticarcinogenic Agents34Locked
Antiproliferative 23Locked
Cyclooxygenase 2 Inhibitors23Locked
Gastrointestinal Agents23Locked
MicroRNA modulator23Locked
Neuroprotective Agents33Locked
Anti-Fibrotic12Locked
Caspase-3 Activation12Locked
Caspase-7 Activation 12Locked
Interleukin-10 downregulation12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor12Locked
Pancreato Protective Agents12Locked
Prostaglandin PGE2 downregulation12Locked
Tumor Suppressor Protein p53 Upregulation12Locked
12-lipoxygenase (12-LOX) Inhibitor11Locked
Anti-Angiogenic11Locked
Antimutagenic Agents11Locked
Bcl-2 protein down-regulation11Locked
Chemoprotective Agents11Locked
Chemotherapeutic11Locked
Cyclooxygenase Inhibitors11Locked
Interleukin-10 upregulation11Locked
Interleukin-6 Downregulation11Locked
NF-kappaB Inhibitor11Locked
Osteoprotective 11Locked
Survivin Down-Regulation11Locked
Vitamin D Receptor (VDR) Modulator11Locked

View the Evidence:
73 Abstracts with Polyunsaturated Fatty Acids (PUFAs) Research

[+]

In trials of 6 weeks there was a significant improvement in insulin resistance in women.Sep 27, 2016

Pubmed Data : Am J Clin Nutr. 2016 Sep 28. Epub 2016 Sep 28. PMID: 27680989
Article Published Date : Sep 27, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Insulin Resistance
[+]

n-3 PUFA supplements may significantly improve cognitive development in infants but do not improve cognitive performance in children.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Clin Nutr. 2014 Dec ;100(6):1422-36. Epub 2014 Oct 15. PMID: 25411277
Article Published Date : Nov 30, 2014
Study Type : Meta Analysis
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Childhood Cognitive Disorders
Additional Keywords : Cognitive Skills
[+]

Omega-3 PUFA are associated with significant improvement in vascular function and lowering of BP.Jul 25, 2016

Pubmed Data : Nutr Metab Cardiovasc Dis. 2016 Jul 26. Epub 2016 Aug 26. PMID: 27692558
Article Published Date : Jul 25, 2016
Study Type : Meta Analysis
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Polyunsaturated fatty acids supplementation can improve liver steatosis and liver functions.Dec 22, 2016

Pubmed Data : Clin Nutr. 2016 Dec 23. Epub 2016 Dec 23. PMID: 28040302
Article Published Date : Dec 22, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Hepatic Steatosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

The present analysis supports the hypothesis that dietary n-3 PUFA intake are associated with lower risk of depression.Aug 15, 2016

Pubmed Data : J Affect Disord. 2016 Aug 16 ;205:269-281. Epub 2016 Aug 16. PMID: 27544316
Article Published Date : Aug 15, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Polyunsaturated Fatty Acids (PUFAs)
Diseases : Depression
Additional Keywords : Risk Reduction
[+]

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

Pubmed Data : J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):367-71. Epub 2006 Apr 28. PMID: 16648143
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin E
Diseases : Amyotrophic Lateral Sclerosis
[+]

Association of total flavonoid intake with hypo-HDL-cholesterolemia among Korean adults: effect modification by polyunsaturated fatty acid intake.Jan 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jan 10 ;12(1). Epub 2020 Jan 10. PMID: 31936778
Article Published Date : Jan 09, 2020
Study Type : Human Study
Additional Links
Substances : Flavonoids, Polyunsaturated Fatty Acids (PUFAs), Proanthocyanidins
Diseases : Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents
[+]

Combination of vitamin C and n-3 PUFA effectively reduces post-operative fatigue among patients who undergo coronary artery bypass graft surgery.Aug 20, 2019

Pubmed Data : J Complement Integr Med. 2019 Aug 21. Epub 2019 Aug 21. PMID: 31433781
Article Published Date : Aug 20, 2019
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin C
Diseases : Coronary Bypass Surgery, Fatigue
[+]

Dietary intake of isoflavones and polyunsaturated fatty acids associated with a Japanese diet reduce lung dysfunction, breathlessness and the prevalence of chronic obstructive pulmonary disease. Jan 28, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Jan 28. Epub 2010 Jan 28. PMID: 20112297
Article Published Date : Jan 28, 2010
Study Type : Human Study
Additional Links
Substances : Isoflavones, Polyunsaturated Fatty Acids (PUFAs)
Diseases : COPD, Smoking
Therapeutic Actions : Dietary Modification: Traditional Japanese Diet
[+]

Dietary n-3 polyunsaturated fatty acids, fish intake and healthy ageing.Sep 27, 2019

Pubmed Data : Int J Epidemiol. 2019 Sep 28. Epub 2019 Sep 28. PMID: 31563961
Article Published Date : Sep 27, 2019
Study Type : Human Study
Additional Links
Substances : Fish, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Aging
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

Dietary polyunsaturated fatty acids intake, air pollution, and the risk of lung cancer.Jul 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Total Environ. 2023 Jul 15 ;882:163552. Epub 2023 Apr 23. PMID: 37094679
Article Published Date : Jul 14, 2023
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Omega-6 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Lung Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Risk Reduction
[+]

Dietary unsaturated fatty acids increase plasma glucagon-like peptide-1 and cholecystokinin and may decrease premeal ghrelin in lactating dairy cows.Apr 01, 2008

Pubmed Data : J Dairy Sci. 2008 Apr;91(4):1443-50. PMID: 18349237
Article Published Date : Apr 01, 2008
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Pharmacological Actions : Cholecystokinin (CCK) Up-regulation, Ghrelin Down-Regulation, Glucagon Like peptide 1 (GLP-1) Up-regulation
[+]

Fish consumption might be associated with resilience to depression.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2015 ;14(1):51. Epub 2015 May 26. PMID: 26007632
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Fish, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Depression
Additional Keywords : Risk Reduction
[+]

High intake of polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) reduce the risk of cognitive decline and dementia associated with Alzheimer's disease and/or vascular dsyfunction. Apr 01, 2005

Pubmed Data : Exp Gerontol. 2005 Apr;40(4):257-70. PMID: 15820606
Article Published Date : Apr 01, 2005
Study Type : Human Study
Additional Links
Substances : Monounsaturated fatty acids, Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Cerebrovascular Disorders
Additional Keywords : Risk Reduction
[+]

High monounsaturated fatty and polyunsaturated fatty acid intake associated with a typical Mediterranean diet protects against age-related cognitive decline. Nov 01, 2006

Pubmed Data : Neurobiol Aging. 2006 Nov;27(11):1694-704. Epub 2005 Oct 26. PMID: 16256248
Article Published Date : Nov 01, 2006
Study Type : Human Study
Additional Links
Substances : Monounsaturated fatty acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cognitive Decline/Dysfunction
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

Higher intake of polyunsaturated fatty acids (PUFA) and fish oil was associated with better semantic memory and global cognitive function. Jul 01, 2008

Pubmed Data : Int J Geriatr Psychiatry. 2008 Jul;23(7):741-7. PMID: 18188871
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
[+]

Immune activity against coronavirus infections are improved by omega-6 polyunsaturated fatty acids in turkeys.Sep 01, 1997

Pubmed Data : Br Poult Sci. 1997 Sep ;38(4):342-8. PMID: 9347140
Article Published Date : Sep 01, 1997
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Coronavirus Disease (Covid-19), Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunomodulatory
[+]

Intake of dietary LCω3PUFA is associated with a decreased risk of sight-threatening diabetic retinopathy.Aug 17, 2016

Pubmed Data : JAMA Ophthalmol. 2016 Aug 18. Epub 2016 Aug 18. PMID: 27541690
Article Published Date : Aug 17, 2016
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Diabetic Retinopathy
Additional Keywords : Risk Reduction
[+]

MUFAs or n-6 PUFAs had beneficial effects on serum lipid biomarkers, blood pressure, and E-selectin offering a potential public health strategy for CVD risk reduction.May 26, 2015

Pubmed Data : Am J Clin Nutr. 2015 May 27. Epub 2015 May 27. PMID: 26016869
Article Published Date : May 26, 2015
Study Type : Human Study
Additional Links
Substances : Monounsaturated fatty acids, Polyunsaturated Fatty Acids (PUFAs), Saturated fatty acids
Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases
Pharmacological Actions : Antihypertensive Agents, Cardioprotective, Cardiovascular Agents, Hypolipidemic
Additional Keywords : Risk Reduction
[+]

n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.Jun 04, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Res Pediatr Endocrinol. 2015 Jun 5 ;7(2):121-7. PMID: 26316434
Article Published Date : Jun 04, 2015
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Hepatoprotective
[+]

Omega-3 polyunsaturated fatty acids may decrease the intensity of symptoms and improve the level of functioning in first-episode schizophrenia patients.Nov 24, 2015

Pubmed Data : J Psychiatr Res. 2015 Nov 25 ;73:34-44. Epub 2015 Nov 25. PMID: 26679763
Article Published Date : Nov 24, 2015
Study Type : Human Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Schizophrenia
[+]

Omega-3 PUFAs may help to reduce all-cause mortality.Sep 12, 2016

Pubmed Data : Nutr Res. 2016 Sep 13. Epub 2016 Aug 13. PMID: 27865614
Article Published Date : Sep 12, 2016
Study Type : Human Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : All-Cause Mortality
Additional Keywords : Risk Reduction
[+]

Polyunsaturated fats alleviate symptoms related to dry eye syndrome. Oct 01, 2006

Pubmed Data : J Fr Ophtalmol. 2006 Oct;29(8):868-73. PMID: 17075501
Article Published Date : Oct 01, 2006
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Dry Eye Syndromes
[+]

Prenatal oxidative balance and risk of asthma and allergic disease in adolescence.Aug 18, 2019

Pubmed Data : J Allergy Clin Immunol. 2019 Aug 19. Epub 2019 Aug 19. PMID: 31437488
Article Published Date : Aug 18, 2019
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin D
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Antioxidants
Additional Keywords : Risk Reduction
[+]

Supplementation with n-3 LCPUFA in the third trimester of pregnancy reduced the absolute risk of persistent wheeze or asthma in offspring.Jan 28, 2016

Pubmed Data : N Engl J Med. 2016 12 29 ;375(26):2530-9. PMID: 28029926
Article Published Date : Jan 28, 2016
Study Type : Human Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Asthma, Wheezing: Infants
Additional Keywords : Risk Reduction
[+]

The consumption of dietary fiber, polyunsaturated fatty acids, fiber, vegetables and fruit is associated with decreased risk of Barett's esophagus.Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(5):607-16. PMID: 19838934
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Fiber, Fruit: All, Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs), Vegetables: All
Diseases : Barrett Esophagus, Esophageal Cancer
Additional Keywords : Risk Reduction
[+]

Vitamin E and polyunsaturated fatty acids are therapeutic in apraxia and perhaps autism spectrum disorders. Jul 01, 2009

Pubmed Data : Altern Ther Health Med. 2009 Jul-Aug;15(4):34-43. PMID: 19623831
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin E
Diseases : Apraxias, Autism Spectrum Disorders
[+]

A high consumption of unsaturated fatty acids is associated with better memory and greater longevityJan 01, 2011

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2011;57(1):36-41. PMID: 21512289
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Polyunsaturated Fatty Acids (PUFAs), Soybean Oil
Diseases : Aging, Aging: Brain , Memory Disorders
[+]

Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization.Jan 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2020 Jan 8 ;19(1):4. Epub 2020 Jan 8. PMID: 31915015
Article Published Date : Jan 07, 2020
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-10 downregulation
[+]

Dietary supplementation with n-3 PUFAs may have protective anti-inflammatory effects mediated through modulation of MMPs and TIMPs.Mar 31, 2015

Pubmed Data : Heart Lung Circ. 2015 Apr ;24(4):377-85. Epub 2014 Nov 20. PMID: 25512019
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Aneurysm: Aortic
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Early dietary supplementation with n-6 and n-3 PUFAs can be powerfully used for protection against metabolic dysfunctions.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Endocrinol. 2016 ;2016:9242319. Epub 2016 Dec 5. PMID: 28050167
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Essential Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Metabolic Diseases, Obesity
Pharmacological Actions : Antioxidants, Pancreato Protective Agents
Problem Substances : Monosodium Glutamate (MSG)
[+]

Fish oils and their combination with grape polyphenols could be beneficial against the negative effects of an unhealthy diet.Dec 20, 2016

Pubmed Data : J Nutr Biochem. 2016 Dec 21 ;41:84-97. Epub 2016 Dec 21. PMID: 28064013
Article Published Date : Dec 20, 2016
Study Type : Animal Study
Additional Links
Substances : Grape, Omega-3 Fatty Acids, Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : High Fat Diet
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.Jan 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Jan 10 ;12(1):381. Epub 2022 Jan 10. PMID: 35013389
Article Published Date : Jan 09, 2022
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Gastrointestinal Agents
[+]

Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet.Oct 31, 2020

Pubmed Data : Food Res Int. 2020 Nov ;137:109706. Epub 2020 Sep 18. PMID: 33233280
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Mulberry, Polyunsaturated Fatty Acids (PUFAs)
Diseases : High Fat Diet, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

n-3 Polyunsaturated fatty acids protect against pancreatic β-cell damage due to ER stress and prevent diabetes development.Jun 14, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Jun 15. Epub 2015 Jun 15. PMID: 26080997
Article Published Date : Jun 14, 2015
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Diabetes Mellitus: Type 2: Prevention
[+]

n-3 PUFA content protected the mice against pro-inflammatory and oxidative stress responses following short-term infusion with angiotensin II. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(11):e112816. Epub 2014 Nov 14. PMID: 25398022
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Aneurysm: Aortic, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

n-3 PUFAs attenuated anti-viral CD8+ T cell responses against acute viral infection and could be used to alleviate immunopathology mediated by viral infection.Sep 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Sep 12 ;20(18). Epub 2019 Sep 12. PMID: 31547227
Article Published Date : Sep 11, 2019
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Hepatitis B , Hepatitis C, HIV Infections, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Omega-3 polyunsaturated fatty acids reduces liver fibrosis and promotes liver regeneration.Oct 31, 2019

Pubmed Data : Eur Rev Med Pharmacol Sci. 2019 Nov ;23(22):10151-10160. PMID: 31799687
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Additional Keywords : Liver Regeneration
[+]

Polyunsaturated fatty acid supplementation stimulates differentiation of oligodendroglia cells, indicating their value in neurological repair. Jan 01, 2006

Pubmed Data : Dev Neurosci. 2006;28(3):196-208. PMID: 16679766
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Gamma-Linoleic Acid (GLA) , Polyunsaturated Fatty Acids (PUFAs)
Diseases : Demyelinating Diseases, Multiple Sclerosis, Neurologic Disorders
[+]

Polyunsaturated fatty acids may have a preventive and thereapeutic role in the treatment of testicular cancer. Aug 01, 2009

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:372-6. PMID: 19723078
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Testicular Cancer
Pharmacological Actions : Apoptotic
[+]

Polyunsaturated fatty acids, vitamin E and lycopene alleviate ambient particulate matter organic extracts-induced oxidative stress.Dec 01, 2022

Pubmed Data : Vet Res Commun. 2022 Dec 2. Epub 2022 Dec 2. PMID: 36456856
Article Published Date : Dec 01, 2022
Study Type : Animal Study
Additional Links
Substances : Lycopene, Polyunsaturated Fatty Acids (PUFAs), Vitamin E
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Antioxidants
[+]

The pro-apoptotic effect of FO in Walker 256 tumor is related with specifics cleaved caspases.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2015 ;14(1):94. Epub 2015 Aug 25. PMID: 26303118
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Tumors
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Tumor Suppressor Protein p53 Upregulation
[+]

These findings provide novel insights into the antidepressant action of PUFAs Jan 04, 2017

Pubmed Data : Eur J Nutr. 2017 Jan 5. Epub 2017 Jan 5. PMID: 28058465
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Brain Inflammation , Depression, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Malondialdehyde Down-regulation
[+]

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015;5:14958. Epub 2015 Oct 15. PMID: 26468779
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Endometrial Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Risk Reduction
[+]

A review evaluating the modulation of miRNAs by dietary agents, which could potentially be exploited for inhibition of mutagenesis and carcinogenesis.Sep 30, 2012

Pubmed Data : Mutat Res. 2012 Oct-Dec;751(2):287-303. Epub 2012 Jun 7. PMID: 22683846
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Isoflavones, Isothiocyanates, Phospholipids, Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, MicroRNA modulator
Additional Keywords : Epigenetic Modification
[+]

Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?Nov 06, 2020

Pubmed Data : Bone. 2020 Nov 7:115736. Epub 2020 Nov 7. PMID: 33171312
Article Published Date : Nov 06, 2020
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Flavonoids and n-3 polyunsaturated fatty acids are strong candidate in preventing neuroinflammation and modulating age-related memory decline.Aug 06, 2015

Pubmed Data : Neurochem Int. 2015 Aug 7. Epub 2015 Aug 7. PMID: 26260547
Article Published Date : Aug 06, 2015
Study Type : Review
Additional Links
Substances : Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Risk Reduction
[+]

Long-term administration of ω-3 PUFAs as a dietary supplement can be used as a strategy either to prevent CAC in patients.Aug 22, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27566583
Article Published Date : Aug 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Survivin Down-Regulation
[+]

Many of the healthspan advantages conferred by 1,25-Dihydroxyvitamin D3 are promulgated by its induction of klotho.Dec 31, 2015

Pubmed Data : Vitam Horm. 2016 ;100:165-230. Epub 2016 Jan 13. PMID: 26827953
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Anthocyanins, Curcumin, Polyunsaturated Fatty Acids (PUFAs), Resveratrol, Vitamin D
Pharmacological Actions : Vitamin D Receptor (VDR) Modulator
Additional Keywords : Gene Expression Regulation
[+]

Melatonin with polyunsaturated fatty acids could exert a synergistic anti-tumor effect on a mammary gland adenocarcinoma.Mar 31, 2015

Pubmed Data : Nutrition. 2015 Apr ;31(4):570-7. Epub 2014 Jun 23. PMID: 25770319
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Melatonin, Polyunsaturated Fatty Acids (PUFAs), Walnut
Diseases : Breast Cancer
Pharmacological Actions : 12-lipoxygenase (12-LOX) Inhibitor, Apoptotic, Cyclooxygenase Inhibitors
Additional Keywords : Natural Substance Synergy
[+]

Modulatory effect of dietary polyunsaturated fatty acids on immunity, represented by phagocytic activity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Vet Sci. 2020 ;7:569939. Epub 2020 Sep 22. PMID: 33195556
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

N-3 fatty acids as preventive and therapeutic agents in attenuating PCOS complications.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2019 ;18:558-575. Epub 2019 Jul 25. PMID: 31611740
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

n-3 polyunsaturated fatty acids in the regulation of adipose tissue browning and thermogenesis in obesity.Dec 28, 2021

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2021 Dec 29 ;177:102388. Epub 2021 Dec 29. PMID: 34995899
Article Published Date : Dec 28, 2021
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Obesity
Pharmacological Actions : Gastrointestinal Agents
[+]

n-3 PUFAs show promise as adjuvants in chemotherapy, enhancing their efficacy while safeguarding hematopoiesis and promoting bone generation.Oct 26, 2023

Pubmed Data : Curr Top Med Chem. 2023 Oct 27. Epub 2023 Oct 27. PMID: 37907485
Article Published Date : Oct 26, 2023
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cancers: All
Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic
[+]

Neurodegenerative disorders such as Parkinson's and Alzheimer's disease appear to exhibit membrane loss of membrane loss of PUFAs.Jun 30, 2000

Pubmed Data : Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):383-99. PMID: 10817922.pdf
Article Published Date : Jun 30, 2000
Study Type : Review
Additional Links
Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Essential Fatty Acids, Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Additional Keywords : Brain Function, Essential Fatty Acids, Membrane Fluidity, omega-3 fatty acids
[+]

Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:3160. Epub 2019 Jan 15. PMID: 30697214
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyunsaturated Fatty Acids (PUFAs), Probiotics, Vitamin D, Vitamin E, Zinc
Diseases : Autoimmune Diseases, Inflammation
Pharmacological Actions : Immunomodulatory
[+]

Omega-3 metabolites may contribute to the beneficial effects against CVDs that are attributed to omega-3 PUFAs.Sep 06, 2015

Pubmed Data : J Cardiol. 2015 Sep 7. Epub 2015 Sep 7. PMID: 26359712
Article Published Date : Sep 06, 2015
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
Additional Keywords : Metabolites
[+]

Omega-3 polyunsaturated fatty acids could be used in the prevention of mood and anxiety disorders.Aug 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Aug 31 ;13(2):129-37. PMID: 26243838
Article Published Date : Aug 30, 2015
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Immunomodulatory
[+]

Polyunsaturated fatty acids (PUFAs) may positively influence the endocannabinoid system.Apr 01, 2002

Pubmed Data : J Nutr. 2002 Apr;132(4):703-7. PMID: 20013888
Article Published Date : Apr 01, 2002
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Endocannabinoid Disorders, Inflammation
[+]

Polyunsaturated fatty acids and DNA methylation in colorectal cancerDec 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Clin Cases. 2019 Dec 26 ;7(24):4172-4185. PMID: 31911898
Article Published Date : Dec 25, 2019
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : DNA Methylation
[+]

Polyunsaturated fatty acids and endocannabinoids in health and disease.Jul 06, 2017

Pubmed Data : Nutr Neurosci. 2017 Jul 7:1-20. Epub 2017 Jul 7. PMID: 28686542
Article Published Date : Jul 06, 2017
Study Type : Review
Additional Links
Substances : Endocannabinoids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Cardiovascular Diseases, Depression, Obesity
Pharmacological Actions : Neuroprotective Agents
[+]

Polyunsaturated fatty acids influence LPS-induced inflammation of fish macrophages.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2020 ;11:559332. Epub 2020 Oct 6. PMID: 33123132
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Polyunsaturated fatty acids may act as ligands for the GLP-1 associated intestinal receptor. Jun 01, 2008

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):515-22. Epub 2008 Mar 5. PMID: 18320172
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation
[+]

PUFAs induced apoptosis of colon cancer cells through a mitochondrial dependent pathway.Oct 11, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Med Sci. 2015 Oct 12 ;11(5):1081-94. PMID: 26528354
Article Published Date : Oct 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic
[+]

The evidence suggests that increased consumption of these compounds might lead to a safe strategy to delay the onset of AD.Dec 31, 2013

Pubmed Data : CNS Neurol Disord Drug Targets. 2014 ;13(7):1175-91. PMID: 25230232
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Catechin , Curcumin, Ginkgo biloba, Green Tea, Polyunsaturated Fatty Acids (PUFAs), Turmeric
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

The growth of tumor cells can be differentially modulated by fatty acids.Dec 31, 2016

Pubmed Data : Arch Med Res. 2017 Jan ;48(1):46-54. PMID: 28577869
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Breast Cancer, Glioblastoma
Pharmacological Actions : Antiproliferative
[+]

Therapeutic potential of ω-3 polyunsaturated fatty acids in human autoimmune diseases.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2019 ;10:2241. Epub 2019 Sep 27. PMID: 31611873
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Autoimmune Diseases, Diabetes Mellitus: Type 1, Multiple Sclerosis, Rheumatoid Arthritis, Systemic Lupus Erythematosus
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

This review describes the differential effects of n-3 and n-6 fatty acids on the immune system, the use of both PUFAs in autoimmunity, and emphasizes the need for a revision to the view that all n-6 fatty acids are pro-inflammatory.Mar 31, 2003

Pubmed Data : Lipids. 2003 Apr ;38(4):323-41. PMID: 12848277
Article Published Date : Mar 31, 2003
Study Type : Review
Additional Links
Substances : Essential Fatty Acids, Omega-3 Fatty Acids, Omega-6 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Autoimmune Diseases, Inflammation
Therapeutic Actions : Dietary Modification: Alteration of Dietary Fat Types and/or Ratios
Additional Keywords : Essential Fatty Acids
[+]

This review provides evidence that nutrition and natural compounds can help in prevention and treatment of this neuroinflammatory disease. Mar 31, 2015

Pubmed Data : Pharmacol Ther. 2015 Apr ;148:85-113. Epub 2014 Nov 27. PMID: 25435020
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Broccoli, Curcumin, EGCG (Epigallocatechin gallate), Polyunsaturated Fatty Acids (PUFAs), Sulforaphane, Vitamin A, Vitamin D, Vitamin E
Diseases : Encephalomyelitis, Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
Additional Keywords : Dietary Modification, Natural Substance Synergy, Significant Treatment Outcome
[+]

This review summarizes recent knowledge about the impact of common nutraceuticals for the regulation of blood pressure.Jan 31, 2020

Pubmed Data : Food Res Int. 2020 Feb ;128:108749. Epub 2019 Nov 7. PMID: 31955788
Article Published Date : Jan 31, 2020
Study Type : Review
Additional Links
Substances : Calcium, Cocoa, Coenzyme Q10, Culinary Herbs and Spices, Flavonoids, Lycopene, Magnesium, Polyunsaturated Fatty Acids (PUFAs), Prebiotics, Vitamin C, Vitamin E
Diseases : Cardiovascular Diseases, Hyperlipidemia, Hypertension, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Cardioprotective, Hypolipidemic
Additional Keywords : Risk Reduction
[+]

Vitamin D and omega-3 polyunsaturated fatty acids in type 1 diabetes modulation.Jan 02, 2022

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2022 Jan 3. Epub 2022 Jan 3. PMID: 34979894
Article Published Date : Jan 02, 2022
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin D
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Vitamin E requirement will increase with an increase in PUFA consumption and with the degree of unsaturation of the PUFA in the diet.Aug 20, 2015

Pubmed Data : Br J Nutr. 2015 Aug 21:1-10. Epub 2015 Aug 21. PMID: 26291567
Article Published Date : Aug 20, 2015
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin E
[+]

ω-3 endocannabinoid epoxides have anti-inflammatory effects. Jul 06, 2017

Pubmed Data : Proc Natl Acad Sci U S A. 2017 Jul 7. Epub 2017 Jul 7. PMID: 28687674
Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Brain Inflammation , Inflammation
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation
Additional Keywords : Cannabinoid Receptors, Dose Response, Endocannabinoid Epoxides

Copyright: tln / 123RF Stock Photo

Polyunsaturated Fatty Acids (PUFAs) Related Articles

Juicing for Fertility: New Study Reveals Natural Way to Enhance IVF Results
Written by GreenMedInfo Research Group
In the quest for parenthood, could the answer lie in a glass of homemade juice? A groundbreaking new study suggests that a simple blend of beetroot, watermelon, and ginger could significantly improve the success rates of in vitro fertilization (IVF) treatments.
What If The Low-Fat Craze Was Based On Flawed Thinking?
Written by Vic Shayne, Ph.D.
Several decades ago the modern world went crazy with its dietary habits. People were told to stop eating fats because they led to weight gain and heart disease. The government was behind this advice as well as the American Heart Association, hospitals, manufacturers of cholesterol-lowering drugs, food manufacturers, dairies and doctors.
High Fat Healing
Written by Annemarie Colbin, Ph.D.
Our scientific dogma says that the latest research is the closest to the truth; yet as soon as new research comes out, it will be obsolete. This paradigm always ignores context. For example, for the past 15 years it has become assumed truth that a low fat diet is a healthy diet. The same people who thirty years ago used to urge us to eat plenty of meat and cheese, shifted to encourage us towards vegetables and low fat salad dressings
Is Cholesterol Really the Villain We Make it Out to Be?
Written by Julie Daniluk
We have been indoctrinated for years to avoid cholesterol, but what if we have been taught wrong? Cholesterol is, in fact, an essential building block for the body and is key to good health. What it all boils down to is what we include, or leave out, of our diets

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.