Polyunsaturated Fatty Acids (PUFAs)

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71 Diseases Researched for Polyunsaturated Fatty Acids (PUFAs)
NameACCKFocus
Depression636Locked
Nonalcoholic fatty liver disease (NAFLD)230Locked
Alzheimer's Disease523Locked
Hypertension221Locked
Asthma220Locked
Childhood Cognitive Disorders120Locked
Cognitive Decline/Dysfunction220Locked
Hepatic Steatosis120Locked
Insulin Resistance120Locked
Obesity516Locked
Cardiovascular Diseases413Locked
Inflammation1013Locked
Aging212Locked
Cardiovascular Disease: Prevention211Locked
All-Cause Mortality110Locked
Amyotrophic Lateral Sclerosis110Locked
Apraxias110Locked
Autism Spectrum Disorders110Locked
Barrett Esophagus110Locked
COPD110Locked
Cerebrovascular Disorders110Locked
Coronary Bypass Surgery110Locked
Coronavirus Disease (Covid-19)110Locked
Coronavirus Infection110Locked
Diabetic Retinopathy110Locked
Dry Eye Syndromes110Locked
Esophageal Cancer110Locked
Fatigue110Locked
Hypercholesterolemia110Locked
Lung Cancer110Locked
Schizophrenia110Locked
Smoking110Locked
Wheezing: Infants110Locked
Brain Inflammation 35Locked
Aneurysm: Aortic24Locked
High Fat Diet24Locked
Multiple Sclerosis34Locked
Autoimmune Diseases33Locked
Colorectal Cancer23Locked
Lipopolysaccharide-Induced Toxicity23Locked
Aging: Brain 12Locked
Air Pollution Linked Toxicity12Locked
Breast Cancer22Locked
Cancers: All22Locked
Demyelinating Diseases12Locked
Diabetes Mellitus: Type 122Locked
Diabetes Mellitus: Type 2: Prevention12Locked
Endometrial Cancer12Locked
HIV Infections12Locked
Hepatitis B 12Locked
Hepatitis C12Locked
Liver Fibrosis12Locked
Memory Disorders12Locked
Metabolic Diseases12Locked
Neurodegenerative Diseases22Locked
Neurologic Disorders12Locked
Oxidative Stress12Locked
Parkinson's Disease22Locked
Testicular Cancer12Locked
Tumors12Locked
Colitis11Locked
Colon Cancer11Locked
Colorectal Cancer: Prevention 11Locked
Encephalomyelitis11Locked
Endocannabinoid Disorders11Locked
Glioblastoma11Locked
Hyperlipidemia11Locked
Osteoporosis11Locked
Polycystic Ovary Syndrome11Locked
Rheumatoid Arthritis11Locked
Systemic Lupus Erythematosus11Locked
45 Pharmacological Actions Researched for Polyunsaturated Fatty Acids (PUFAs)
NameACCKFocus
Hepatoprotective434Locked
Antihypertensive Agents331Locked
Anti-Inflammatory Agents1722Locked
Antioxidants619Locked
Immunomodulatory717Locked
Chemopreventive415Locked
Cardioprotective312Locked
Hypolipidemic312Locked
Glucagon Like peptide 1 (GLP-1) Up-regulation211Locked
Anti-Asthmatic Agents110Locked
Anticholesteremic Agents110Locked
Antiviral Agents110Locked
Cardiovascular Agents110Locked
Cholecystokinin (CCK) Up-regulation110Locked
Ghrelin Down-Regulation110Locked
Apoptotic46Locked
Antidepressive Agents35Locked
Anticarcinogenic Agents34Locked
Antiproliferative 23Locked
Cyclooxygenase 2 Inhibitors23Locked
Gastrointestinal Agents23Locked
MicroRNA modulator23Locked
Neuroprotective Agents33Locked
Anti-Fibrotic12Locked
Caspase-3 Activation12Locked
Caspase-7 Activation 12Locked
Interleukin-10 downregulation12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor12Locked
Pancreato Protective Agents12Locked
Prostaglandin PGE2 downregulation12Locked
Tumor Suppressor Protein p53 Upregulation12Locked
12-lipoxygenase (12-LOX) Inhibitor11Locked
Anti-Angiogenic11Locked
Antimutagenic Agents11Locked
Bcl-2 protein down-regulation11Locked
Chemoprotective Agents11Locked
Chemotherapeutic11Locked
Cyclooxygenase Inhibitors11Locked
Interleukin-10 upregulation11Locked
Interleukin-6 Downregulation11Locked
NF-kappaB Inhibitor11Locked
Osteoprotective 11Locked
Survivin Down-Regulation11Locked
Vitamin D Receptor (VDR) Modulator11Locked

View the Evidence:
73 Abstracts with Polyunsaturated Fatty Acids (PUFAs) Research

[+]

In trials of 6 weeks there was a significant improvement in insulin resistance in women.Sep 27, 2016

Pubmed Data : Am J Clin Nutr. 2016 Sep 28. Epub 2016 Sep 28. PMID: 27680989
Article Published Date : Sep 27, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Insulin Resistance
[+]

n-3 PUFA supplements may significantly improve cognitive development in infants but do not improve cognitive performance in children.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Clin Nutr. 2014 Dec ;100(6):1422-36. Epub 2014 Oct 15. PMID: 25411277
Article Published Date : Nov 30, 2014
Study Type : Meta Analysis
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Childhood Cognitive Disorders
Additional Keywords : Cognitive Skills
[+]

Omega-3 PUFA are associated with significant improvement in vascular function and lowering of BP.Jul 25, 2016

Pubmed Data : Nutr Metab Cardiovasc Dis. 2016 Jul 26. Epub 2016 Aug 26. PMID: 27692558
Article Published Date : Jul 25, 2016
Study Type : Meta Analysis
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Polyunsaturated fatty acids supplementation can improve liver steatosis and liver functions.Dec 22, 2016

Pubmed Data : Clin Nutr. 2016 Dec 23. Epub 2016 Dec 23. PMID: 28040302
Article Published Date : Dec 22, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Hepatic Steatosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

The present analysis supports the hypothesis that dietary n-3 PUFA intake are associated with lower risk of depression.Aug 15, 2016

Pubmed Data : J Affect Disord. 2016 Aug 16 ;205:269-281. Epub 2016 Aug 16. PMID: 27544316
Article Published Date : Aug 15, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Polyunsaturated Fatty Acids (PUFAs)
Diseases : Depression
Additional Keywords : Risk Reduction
[+]

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

Pubmed Data : J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):367-71. Epub 2006 Apr 28. PMID: 16648143
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin E
Diseases : Amyotrophic Lateral Sclerosis
[+]

Association of total flavonoid intake with hypo-HDL-cholesterolemia among Korean adults: effect modification by polyunsaturated fatty acid intake.Jan 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jan 10 ;12(1). Epub 2020 Jan 10. PMID: 31936778
Article Published Date : Jan 09, 2020
Study Type : Human Study
Additional Links
Substances : Flavonoids, Polyunsaturated Fatty Acids (PUFAs), Proanthocyanidins
Diseases : Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents
[+]

Combination of vitamin C and n-3 PUFA effectively reduces post-operative fatigue among patients who undergo coronary artery bypass graft surgery.Aug 20, 2019

Pubmed Data : J Complement Integr Med. 2019 Aug 21. Epub 2019 Aug 21. PMID: 31433781
Article Published Date : Aug 20, 2019
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin C
Diseases : Coronary Bypass Surgery, Fatigue
[+]

Dietary intake of isoflavones and polyunsaturated fatty acids associated with a Japanese diet reduce lung dysfunction, breathlessness and the prevalence of chronic obstructive pulmonary disease. Jan 28, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Jan 28. Epub 2010 Jan 28. PMID: 20112297
Article Published Date : Jan 28, 2010
Study Type : Human Study
Additional Links
Substances : Isoflavones, Polyunsaturated Fatty Acids (PUFAs)
Diseases : COPD, Smoking
Therapeutic Actions : Dietary Modification: Traditional Japanese Diet
[+]

Dietary n-3 polyunsaturated fatty acids, fish intake and healthy ageing.Sep 27, 2019

Pubmed Data : Int J Epidemiol. 2019 Sep 28. Epub 2019 Sep 28. PMID: 31563961
Article Published Date : Sep 27, 2019
Study Type : Human Study
Additional Links
Substances : Fish, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Aging
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

Dietary polyunsaturated fatty acids intake, air pollution, and the risk of lung cancer.Jul 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Total Environ. 2023 Jul 15 ;882:163552. Epub 2023 Apr 23. PMID: 37094679
Article Published Date : Jul 14, 2023
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Omega-6 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Lung Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Risk Reduction
[+]

Dietary unsaturated fatty acids increase plasma glucagon-like peptide-1 and cholecystokinin and may decrease premeal ghrelin in lactating dairy cows.Apr 01, 2008

Pubmed Data : J Dairy Sci. 2008 Apr;91(4):1443-50. PMID: 18349237
Article Published Date : Apr 01, 2008
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Pharmacological Actions : Cholecystokinin (CCK) Up-regulation, Ghrelin Down-Regulation, Glucagon Like peptide 1 (GLP-1) Up-regulation
[+]

Fish consumption might be associated with resilience to depression.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2015 ;14(1):51. Epub 2015 May 26. PMID: 26007632
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Fish, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Depression
Additional Keywords : Risk Reduction
[+]

High intake of polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) reduce the risk of cognitive decline and dementia associated with Alzheimer's disease and/or vascular dsyfunction. Apr 01, 2005

Pubmed Data : Exp Gerontol. 2005 Apr;40(4):257-70. PMID: 15820606
Article Published Date : Apr 01, 2005
Study Type : Human Study
Additional Links
Substances : Monounsaturated fatty acids, Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Cerebrovascular Disorders
Additional Keywords : Risk Reduction
[+]

High monounsaturated fatty and polyunsaturated fatty acid intake associated with a typical Mediterranean diet protects against age-related cognitive decline. Nov 01, 2006

Pubmed Data : Neurobiol Aging. 2006 Nov;27(11):1694-704. Epub 2005 Oct 26. PMID: 16256248
Article Published Date : Nov 01, 2006
Study Type : Human Study
Additional Links
Substances : Monounsaturated fatty acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cognitive Decline/Dysfunction
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

Higher intake of polyunsaturated fatty acids (PUFA) and fish oil was associated with better semantic memory and global cognitive function. Jul 01, 2008

Pubmed Data : Int J Geriatr Psychiatry. 2008 Jul;23(7):741-7. PMID: 18188871
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
[+]

Immune activity against coronavirus infections are improved by omega-6 polyunsaturated fatty acids in turkeys.Sep 01, 1997

Pubmed Data : Br Poult Sci. 1997 Sep ;38(4):342-8. PMID: 9347140
Article Published Date : Sep 01, 1997
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Coronavirus Disease (Covid-19), Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunomodulatory
[+]

Intake of dietary LCω3PUFA is associated with a decreased risk of sight-threatening diabetic retinopathy.Aug 17, 2016

Pubmed Data : JAMA Ophthalmol. 2016 Aug 18. Epub 2016 Aug 18. PMID: 27541690
Article Published Date : Aug 17, 2016
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Diabetic Retinopathy
Additional Keywords : Risk Reduction
[+]

MUFAs or n-6 PUFAs had beneficial effects on serum lipid biomarkers, blood pressure, and E-selectin offering a potential public health strategy for CVD risk reduction.May 26, 2015

Pubmed Data : Am J Clin Nutr. 2015 May 27. Epub 2015 May 27. PMID: 26016869
Article Published Date : May 26, 2015
Study Type : Human Study
Additional Links
Substances : Monounsaturated fatty acids, Polyunsaturated Fatty Acids (PUFAs), Saturated fatty acids
Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases
Pharmacological Actions : Antihypertensive Agents, Cardioprotective, Cardiovascular Agents, Hypolipidemic
Additional Keywords : Risk Reduction
[+]

n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.Jun 04, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Res Pediatr Endocrinol. 2015 Jun 5 ;7(2):121-7. PMID: 26316434
Article Published Date : Jun 04, 2015
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Hepatoprotective
[+]

Omega-3 polyunsaturated fatty acids may decrease the intensity of symptoms and improve the level of functioning in first-episode schizophrenia patients.Nov 24, 2015

Pubmed Data : J Psychiatr Res. 2015 Nov 25 ;73:34-44. Epub 2015 Nov 25. PMID: 26679763
Article Published Date : Nov 24, 2015
Study Type : Human Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Schizophrenia
[+]

Omega-3 PUFAs may help to reduce all-cause mortality.Sep 12, 2016

Pubmed Data : Nutr Res. 2016 Sep 13. Epub 2016 Aug 13. PMID: 27865614
Article Published Date : Sep 12, 2016
Study Type : Human Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : All-Cause Mortality
Additional Keywords : Risk Reduction
[+]

Polyunsaturated fats alleviate symptoms related to dry eye syndrome. Oct 01, 2006

Pubmed Data : J Fr Ophtalmol. 2006 Oct;29(8):868-73. PMID: 17075501
Article Published Date : Oct 01, 2006
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Dry Eye Syndromes
[+]

Prenatal oxidative balance and risk of asthma and allergic disease in adolescence.Aug 18, 2019

Pubmed Data : J Allergy Clin Immunol. 2019 Aug 19. Epub 2019 Aug 19. PMID: 31437488
Article Published Date : Aug 18, 2019
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin D
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Antioxidants
Additional Keywords : Risk Reduction
[+]

Supplementation with n-3 LCPUFA in the third trimester of pregnancy reduced the absolute risk of persistent wheeze or asthma in offspring.Jan 28, 2016

Pubmed Data : N Engl J Med. 2016 12 29 ;375(26):2530-9. PMID: 28029926
Article Published Date : Jan 28, 2016
Study Type : Human Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Asthma, Wheezing: Infants
Additional Keywords : Risk Reduction
[+]

The consumption of dietary fiber, polyunsaturated fatty acids, fiber, vegetables and fruit is associated with decreased risk of Barett's esophagus.Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(5):607-16. PMID: 19838934
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Fiber, Fruit: All, Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs), Vegetables: All
Diseases : Barrett Esophagus, Esophageal Cancer
Additional Keywords : Risk Reduction
[+]

Vitamin E and polyunsaturated fatty acids are therapeutic in apraxia and perhaps autism spectrum disorders. Jul 01, 2009

Pubmed Data : Altern Ther Health Med. 2009 Jul-Aug;15(4):34-43. PMID: 19623831
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin E
Diseases : Apraxias, Autism Spectrum Disorders
[+]

A high consumption of unsaturated fatty acids is associated with better memory and greater longevityJan 01, 2011

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2011;57(1):36-41. PMID: 21512289
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Polyunsaturated Fatty Acids (PUFAs), Soybean Oil
Diseases : Aging, Aging: Brain , Memory Disorders
[+]

Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization.Jan 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2020 Jan 8 ;19(1):4. Epub 2020 Jan 8. PMID: 31915015
Article Published Date : Jan 07, 2020
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-10 downregulation
[+]

Dietary supplementation with n-3 PUFAs may have protective anti-inflammatory effects mediated through modulation of MMPs and TIMPs.Mar 31, 2015

Pubmed Data : Heart Lung Circ. 2015 Apr ;24(4):377-85. Epub 2014 Nov 20. PMID: 25512019
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Aneurysm: Aortic
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Early dietary supplementation with n-6 and n-3 PUFAs can be powerfully used for protection against metabolic dysfunctions.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Endocrinol. 2016 ;2016:9242319. Epub 2016 Dec 5. PMID: 28050167
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Essential Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Metabolic Diseases, Obesity
Pharmacological Actions : Antioxidants, Pancreato Protective Agents
Problem Substances : Monosodium Glutamate (MSG)
[+]

Fish oils and their combination with grape polyphenols could be beneficial against the negative effects of an unhealthy diet.Dec 20, 2016

Pubmed Data : J Nutr Biochem. 2016 Dec 21 ;41:84-97. Epub 2016 Dec 21. PMID: 28064013
Article Published Date : Dec 20, 2016
Study Type : Animal Study
Additional Links
Substances : Grape, Omega-3 Fatty Acids, Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : High Fat Diet
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.Jan 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Jan 10 ;12(1):381. Epub 2022 Jan 10. PMID: 35013389
Article Published Date : Jan 09, 2022
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Gastrointestinal Agents
[+]

Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet.Oct 31, 2020

Pubmed Data : Food Res Int. 2020 Nov ;137:109706. Epub 2020 Sep 18. PMID: 33233280
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Mulberry, Polyunsaturated Fatty Acids (PUFAs)
Diseases : High Fat Diet, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

n-3 Polyunsaturated fatty acids protect against pancreatic β-cell damage due to ER stress and prevent diabetes development.Jun 14, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Jun 15. Epub 2015 Jun 15. PMID: 26080997
Article Published Date : Jun 14, 2015
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Diabetes Mellitus: Type 2: Prevention
[+]

n-3 PUFA content protected the mice against pro-inflammatory and oxidative stress responses following short-term infusion with angiotensin II. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(11):e112816. Epub 2014 Nov 14. PMID: 25398022
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Aneurysm: Aortic, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

n-3 PUFAs attenuated anti-viral CD8+ T cell responses against acute viral infection and could be used to alleviate immunopathology mediated by viral infection.Sep 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Sep 12 ;20(18). Epub 2019 Sep 12. PMID: 31547227
Article Published Date : Sep 11, 2019
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Hepatitis B , Hepatitis C, HIV Infections, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Omega-3 polyunsaturated fatty acids reduces liver fibrosis and promotes liver regeneration.Oct 31, 2019

Pubmed Data : Eur Rev Med Pharmacol Sci. 2019 Nov ;23(22):10151-10160. PMID: 31799687
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Additional Keywords : Liver Regeneration
[+]

Polyunsaturated fatty acid supplementation stimulates differentiation of oligodendroglia cells, indicating their value in neurological repair. Jan 01, 2006

Pubmed Data : Dev Neurosci. 2006;28(3):196-208. PMID: 16679766
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Gamma-Linoleic Acid (GLA) , Polyunsaturated Fatty Acids (PUFAs)
Diseases : Demyelinating Diseases, Multiple Sclerosis, Neurologic Disorders
[+]

Polyunsaturated fatty acids may have a preventive and thereapeutic role in the treatment of testicular cancer. Aug 01, 2009

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:372-6. PMID: 19723078
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Testicular Cancer
Pharmacological Actions : Apoptotic
[+]

Polyunsaturated fatty acids, vitamin E and lycopene alleviate ambient particulate matter organic extracts-induced oxidative stress.Dec 01, 2022

Pubmed Data : Vet Res Commun. 2022 Dec 2. Epub 2022 Dec 2. PMID: 36456856
Article Published Date : Dec 01, 2022
Study Type : Animal Study
Additional Links
Substances : Lycopene, Polyunsaturated Fatty Acids (PUFAs), Vitamin E
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Antioxidants
[+]

The pro-apoptotic effect of FO in Walker 256 tumor is related with specifics cleaved caspases.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2015 ;14(1):94. Epub 2015 Aug 25. PMID: 26303118
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Tumors
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Tumor Suppressor Protein p53 Upregulation
[+]

These findings provide novel insights into the antidepressant action of PUFAs Jan 04, 2017

Pubmed Data : Eur J Nutr. 2017 Jan 5. Epub 2017 Jan 5. PMID: 28058465
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Brain Inflammation , Depression, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Malondialdehyde Down-regulation
[+]

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015;5:14958. Epub 2015 Oct 15. PMID: 26468779
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Endometrial Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Risk Reduction
[+]

A review evaluating the modulation of miRNAs by dietary agents, which could potentially be exploited for inhibition of mutagenesis and carcinogenesis.Sep 30, 2012

Pubmed Data : Mutat Res. 2012 Oct-Dec;751(2):287-303. Epub 2012 Jun 7. PMID: 22683846
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Isoflavones, Isothiocyanates, Phospholipids, Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, MicroRNA modulator
Additional Keywords : Epigenetic Modification
[+]

Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?Nov 06, 2020

Pubmed Data : Bone. 2020 Nov 7:115736. Epub 2020 Nov 7. PMID: 33171312
Article Published Date : Nov 06, 2020
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Flavonoids and n-3 polyunsaturated fatty acids are strong candidate in preventing neuroinflammation and modulating age-related memory decline.Aug 06, 2015

Pubmed Data : Neurochem Int. 2015 Aug 7. Epub 2015 Aug 7. PMID: 26260547
Article Published Date : Aug 06, 2015
Study Type : Review
Additional Links
Substances : Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Risk Reduction
[+]

Long-term administration of ω-3 PUFAs as a dietary supplement can be used as a strategy either to prevent CAC in patients.Aug 22, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27566583
Article Published Date : Aug 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Survivin Down-Regulation
[+]

Many of the healthspan advantages conferred by 1,25-Dihydroxyvitamin D3 are promulgated by its induction of klotho.Dec 31, 2015

Pubmed Data : Vitam Horm. 2016 ;100:165-230. Epub 2016 Jan 13. PMID: 26827953
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Anthocyanins, Curcumin, Polyunsaturated Fatty Acids (PUFAs), Resveratrol, Vitamin D
Pharmacological Actions : Vitamin D Receptor (VDR) Modulator
Additional Keywords : Gene Expression Regulation
[+]

Melatonin with polyunsaturated fatty acids could exert a synergistic anti-tumor effect on a mammary gland adenocarcinoma.Mar 31, 2015

Pubmed Data : Nutrition. 2015 Apr ;31(4):570-7. Epub 2014 Jun 23. PMID: 25770319
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Melatonin, Polyunsaturated Fatty Acids (PUFAs), Walnut
Diseases : Breast Cancer
Pharmacological Actions : 12-lipoxygenase (12-LOX) Inhibitor, Apoptotic, Cyclooxygenase Inhibitors
Additional Keywords : Natural Substance Synergy
[+]

Modulatory effect of dietary polyunsaturated fatty acids on immunity, represented by phagocytic activity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Vet Sci. 2020 ;7:569939. Epub 2020 Sep 22. PMID: 33195556
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

N-3 fatty acids as preventive and therapeutic agents in attenuating PCOS complications.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2019 ;18:558-575. Epub 2019 Jul 25. PMID: 31611740
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

n-3 polyunsaturated fatty acids in the regulation of adipose tissue browning and thermogenesis in obesity.Dec 28, 2021

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2021 Dec 29 ;177:102388. Epub 2021 Dec 29. PMID: 34995899
Article Published Date : Dec 28, 2021
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Obesity
Pharmacological Actions : Gastrointestinal Agents
[+]

n-3 PUFAs show promise as adjuvants in chemotherapy, enhancing their efficacy while safeguarding hematopoiesis and promoting bone generation.Oct 26, 2023

Pubmed Data : Curr Top Med Chem. 2023 Oct 27. Epub 2023 Oct 27. PMID: 37907485
Article Published Date : Oct 26, 2023
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cancers: All
Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic
[+]

Neurodegenerative disorders such as Parkinson's and Alzheimer's disease appear to exhibit membrane loss of membrane loss of PUFAs.Jun 30, 2000

Pubmed Data : Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):383-99. PMID: 10817922.pdf
Article Published Date : Jun 30, 2000
Study Type : Review
Additional Links
Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Essential Fatty Acids, Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Additional Keywords : Brain Function, Essential Fatty Acids, Membrane Fluidity, omega-3 fatty acids
[+]

Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:3160. Epub 2019 Jan 15. PMID: 30697214
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyunsaturated Fatty Acids (PUFAs), Probiotics, Vitamin D, Vitamin E, Zinc
Diseases : Autoimmune Diseases, Inflammation
Pharmacological Actions : Immunomodulatory
[+]

Omega-3 metabolites may contribute to the beneficial effects against CVDs that are attributed to omega-3 PUFAs.Sep 06, 2015

Pubmed Data : J Cardiol. 2015 Sep 7. Epub 2015 Sep 7. PMID: 26359712
Article Published Date : Sep 06, 2015
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
Additional Keywords : Metabolites
[+]

Omega-3 polyunsaturated fatty acids could be used in the prevention of mood and anxiety disorders.Aug 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Aug 31 ;13(2):129-37. PMID: 26243838
Article Published Date : Aug 30, 2015
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Immunomodulatory
[+]

Polyunsaturated fatty acids (PUFAs) may positively influence the endocannabinoid system.Apr 01, 2002

Pubmed Data : J Nutr. 2002 Apr;132(4):703-7. PMID: 20013888
Article Published Date : Apr 01, 2002
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Endocannabinoid Disorders, Inflammation
[+]

Polyunsaturated fatty acids and DNA methylation in colorectal cancerDec 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Clin Cases. 2019 Dec 26 ;7(24):4172-4185. PMID: 31911898
Article Published Date : Dec 25, 2019
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : DNA Methylation
[+]

Polyunsaturated fatty acids and endocannabinoids in health and disease.Jul 06, 2017

Pubmed Data : Nutr Neurosci. 2017 Jul 7:1-20. Epub 2017 Jul 7. PMID: 28686542
Article Published Date : Jul 06, 2017
Study Type : Review
Additional Links
Substances : Endocannabinoids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Alzheimer's Disease, Cardiovascular Diseases, Depression, Obesity
Pharmacological Actions : Neuroprotective Agents
[+]

Polyunsaturated fatty acids influence LPS-induced inflammation of fish macrophages.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2020 ;11:559332. Epub 2020 Oct 6. PMID: 33123132
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Polyunsaturated fatty acids may act as ligands for the GLP-1 associated intestinal receptor. Jun 01, 2008

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):515-22. Epub 2008 Mar 5. PMID: 18320172
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation
[+]

PUFAs induced apoptosis of colon cancer cells through a mitochondrial dependent pathway.Oct 11, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Med Sci. 2015 Oct 12 ;11(5):1081-94. PMID: 26528354
Article Published Date : Oct 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic
[+]

The evidence suggests that increased consumption of these compounds might lead to a safe strategy to delay the onset of AD.Dec 31, 2013

Pubmed Data : CNS Neurol Disord Drug Targets. 2014 ;13(7):1175-91. PMID: 25230232
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Catechin , Curcumin, Ginkgo biloba, Green Tea, Polyunsaturated Fatty Acids (PUFAs), Turmeric
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

The growth of tumor cells can be differentially modulated by fatty acids.Dec 31, 2016

Pubmed Data : Arch Med Res. 2017 Jan ;48(1):46-54. PMID: 28577869
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Breast Cancer, Glioblastoma
Pharmacological Actions : Antiproliferative
[+]

Therapeutic potential of ω-3 polyunsaturated fatty acids in human autoimmune diseases.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2019 ;10:2241. Epub 2019 Sep 27. PMID: 31611873
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Autoimmune Diseases, Diabetes Mellitus: Type 1, Multiple Sclerosis, Rheumatoid Arthritis, Systemic Lupus Erythematosus
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

This review describes the differential effects of n-3 and n-6 fatty acids on the immune system, the use of both PUFAs in autoimmunity, and emphasizes the need for a revision to the view that all n-6 fatty acids are pro-inflammatory.Mar 31, 2003

Pubmed Data : Lipids. 2003 Apr ;38(4):323-41. PMID: 12848277
Article Published Date : Mar 31, 2003
Study Type : Review
Additional Links
Substances : Essential Fatty Acids, Omega-3 Fatty Acids, Omega-6 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Autoimmune Diseases, Inflammation
Therapeutic Actions : Dietary Modification: Alteration of Dietary Fat Types and/or Ratios
Additional Keywords : Essential Fatty Acids
[+]

This review provides evidence that nutrition and natural compounds can help in prevention and treatment of this neuroinflammatory disease. Mar 31, 2015

Pubmed Data : Pharmacol Ther. 2015 Apr ;148:85-113. Epub 2014 Nov 27. PMID: 25435020
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Broccoli, Curcumin, EGCG (Epigallocatechin gallate), Polyunsaturated Fatty Acids (PUFAs), Sulforaphane, Vitamin A, Vitamin D, Vitamin E
Diseases : Encephalomyelitis, Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
Additional Keywords : Dietary Modification, Natural Substance Synergy, Significant Treatment Outcome
[+]

This review summarizes recent knowledge about the impact of common nutraceuticals for the regulation of blood pressure.Jan 31, 2020

Pubmed Data : Food Res Int. 2020 Feb ;128:108749. Epub 2019 Nov 7. PMID: 31955788
Article Published Date : Jan 31, 2020
Study Type : Review
Additional Links
Substances : Calcium, Cocoa, Coenzyme Q10, Culinary Herbs and Spices, Flavonoids, Lycopene, Magnesium, Polyunsaturated Fatty Acids (PUFAs), Prebiotics, Vitamin C, Vitamin E
Diseases : Cardiovascular Diseases, Hyperlipidemia, Hypertension, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Cardioprotective, Hypolipidemic
Additional Keywords : Risk Reduction
[+]

Vitamin D and omega-3 polyunsaturated fatty acids in type 1 diabetes modulation.Jan 02, 2022

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2022 Jan 3. Epub 2022 Jan 3. PMID: 34979894
Article Published Date : Jan 02, 2022
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin D
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Vitamin E requirement will increase with an increase in PUFA consumption and with the degree of unsaturation of the PUFA in the diet.Aug 20, 2015

Pubmed Data : Br J Nutr. 2015 Aug 21:1-10. Epub 2015 Aug 21. PMID: 26291567
Article Published Date : Aug 20, 2015
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin E
[+]

ω-3 endocannabinoid epoxides have anti-inflammatory effects. Jul 06, 2017

Pubmed Data : Proc Natl Acad Sci U S A. 2017 Jul 7. Epub 2017 Jul 7. PMID: 28687674
Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Brain Inflammation , Inflammation
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation
Additional Keywords : Cannabinoid Receptors, Dose Response, Endocannabinoid Epoxides

Copyright: tln / 123RF Stock Photo

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