Pomegranate

Name	AC	CK
Oxidative Stress	31	126
Diabetes Mellitus: Type 2	11	84
Hypertension	10	59
Lipid Peroxidation	11	54
Inflammation	18	53
Hemodialysis	4	50
Prostate Cancer	12	48
Cardiovascular Diseases	4	41
Endothelial Dysfunction	4	36
Obesity	12	34
Polycystic Ovary Syndrome	3	30
Atherosclerosis	7	28
Breast Cancer	16	27
Rheumatoid Arthritis	6	26
Triglycerides: Elevated	4	24
Lipopolysaccharide-Induced Toxicity	4	22
Endotoxemia	2	20
Insulin Resistance	2	20
Intima Media Thickening	2	20
Nonalcoholic fatty liver disease (NAFLD)	7	20
Overweight	2	20
Prostate: PSA Doubling	2	20
Hyperglycemia	6	18
Diabetes: Oxidative Stress	4	16
Menopausal Syndrome	4	16
Chemically-Induced Liver Damage	7	15
Dysbiosis	4	15
Wound Healing	9	15
Alzheimer's Disease	9	14
Cognitive Decline/Dysfunction	3	14
Colorectal Cancer	3	14
Memory Disorders	3	14
Ulcerative Colitis	3	14
Aging Skin	3	13
Diabetic Complications	7	13
Neurodegenerative Diseases	7	13
Osteoarthritis	6	13
Arteriosclerosis	2	12
Chemotherapy and Radiation Toxicity	2	12
High Fat Diet	5	12
Liver Fibrosis	5	12
Lung Injury: Smoke-Induced	3	12
Metabolic Syndrome X	2	12
Myocardial Ischemia	2	12
Osteoarthritis: Knee	2	12
Periodontal Diseases	2	12
Streptococcus Infections	3	12
Ultraviolet Radiation Induced Damage	2	12
Athletic Performance	2	11
Athletic Performance: Recovery	2	11
Hyperlipidemia	6	11
Metabolic Diseases	2	11
Periodontitis	2	11
Staphylococcus aureus infection	11	11
Aging: Brain	1	10
Angina Pectoris	1	10
Arterial Thickening	1	10
C-Reactive Protein	1	10
Carotid Artery Narrowing	1	10
Carotid Stenosis	1	10
Chemotherapy-Induced Toxicity: Gentamicin	5	10
Cholesterol: Oxidation	1	10
Chronic Kidney Disease (CKD)	1	10
Dyslipidemias	1	10
Head and Neck Cancer	1	10
High Cholesterol	1	10
Kidney Failure	1	10
Memory Loss	1	10
Muscle Damage	1	10
Muscle Damage: Exercise-Induced	1	10
Muscle Soreness: Exercise-Induced	1	10
Nicotine/Tobacco Toxicity	1	10
Prenatal Chemical Exposures	1	10
Radiation Induced Illness: Mucositis	1	10
Smoking Cessation: Nicotine Addiction	1	10
Stroke: Attenuation/Recovery	1	10
Wrinkles	1	10
Cancers: All	9	9
Candidiasis	3	9
Liver Cancer	6	9
Osteoporosis	5	9
Chemotherapy-Induced Toxicity: Cisplatin	5	8
Kidney Damage	4	8
Escherichia coli Infections	7	7
Aluminum Toxicity	2	6
Colitis	3	6
Colon Cancer	5	6
Drug Toxicity: Methotrexate	2	6
Hepatic Steatosis	3	6
Lung Cancer	5	6
Multiple Myeloma	2	6
Benzo[a]pyrene-induced Toxicity	3	5
Coronary Artery Disease	3	5
Salmonella Infections	4	5
Staphylococcus epidermidis	4	5
Tobacco Toxicity	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Aging	2	4
Barium Toxicity	2	4
Bladder Cancer	2	4
Brain Hypoxia	2	4
Brain Ischemia	2	4
Brain: Oxidative Stress	2	4
Burns	2	4
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	4
Chemotherapy-Induced Toxicity: 5-fluorouracil	3	4
Citrobacter Infection	2	4
DNA damage	2	4
Depression: Postmenopausal	2	4
Fungal Infection	3	4
Hypoglycemia	3	4
Infertility: Male	2	4
Inflammatory Bowel Diseases	3	4
Ischemia	2	4
Kidney Damage: Chemically-Induced	2	4
Klebsiella Infections	3	4
Liver Damage	2	4
Malaria	2	4
Pseudomonas aeruginosa	4	4
Acne	2	3
Advanced Glycation End products (AGE)	2	3
Breast Cancer: Triple Negative	3	3
Cancer Metastasis	2	3
Candida Albicans	2	3
Cervical Cancer	2	3
Diabetes	2	3
Diabetes: Cognitive Dysfunction	2	3
Estrogen Deficiency	2	3
Kidney Stones	2	3
Leishmaniasis	2	3
Listeria Infections	3	3
Ovarian Cancer	2	3
Parasitic Diseases	2	3
Skin Diseases: Photo-Aging	3	3
Steptococcus Mutans Infections	3	3
Air Pollution Linked Toxicity	2	2
Alcohol Toxicity	1	2
Antibiotic Toxicity	1	2
Anxiety	1	2
Anxiety Disorders	1	2
Arthritis	1	2
Aspirin-Induced Toxicity	1	2
Bacillus Cereus infection	2	2
Biliary Obstruction	1	2
Blood Sugar Problems	1	2
Brain Inflammation	2	2
Brain: Microglial Activation	1	2
Breast Cancer Stem Cells	2	2
Cachexia	1	2
Cancer: Prostate	1	2
Candida Infection	2	2
Carcinoma: Non-Small-Cell Lung	2	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Cerebral Ischemia	1	2
Chemical Exposure	1	2
Chemotherapy-Induced Liver Toxicity	1	2
Chemotherapy-Induced Toxicity	1	2
Chronic Obstructive Pulmonary Disease	1	2
Clogged Arteries	1	2
Colitis: Ulcerative	1	2
Coronavirus Infection	2	2
Creutzfeldt-Jakob disease	1	2
Cystitis: Hemorrhagic	1	2
Dementia	1	2
Depression	1	2
Dermatitis: Contact	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetic Retinopathy	1	2
Diarrhea	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Encephalomyelitis	1	2
Erectile Dysfunction	1	2
Fetal Origin of Adult Disease	1	2
Fibrosis: Liver	1	2
Fluoride Toxicity	1	2
Gastric Ulcer	1	2
Gastrointestinal Inflammation	1	2
Gestational Diabetes	1	2
HIV Infections	2	2
Hearing Loss	1	2
Hepatitis: Autoimmune	1	2
High Fructose Diet	1	2
Hypercholesterolemia	1	2
Hyperpigmentation	2	2
Hypoxia	1	2
Immune Disorders: Low Immune Function	1	2
Infertility	1	2
Influenza	2	2
Influenza A	2	2
Jaundice	1	2
Jaundice: Post-Hepatic/Obstructive	1	2
Kidney Failure: Acute	1	2
Lead Poisoning	1	2
Leukemia	2	2
Lung Cancer: Metastatic	1	2
Lung Cancer: Prevention	1	2
Lung Injury: Acute	1	2
Melanoma	1	2
Memory Disorders: Drug-Induced	1	2
Mycobacterium tuberculosis	2	2
NSAID-induced toxicity	1	2
Oral Cancer	2	2
Pancreatic Cancer	2	2
Pancreatitis	1	2
Parkinson's Disease	1	2
Pesticide Toxicity	1	2
Porphyromonas gingivalis	1	2
Pregnancy Complications	1	2
Prion Diseases	1	2
Prostate Cancer: Prevention	1	2
Radiation Induced Illness	1	2
Respiratory Infections	1	2
Sepsis	1	2
Skin Cancer: Prevention	1	2
Smoking	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stress	1	2
Subarachnoid hemorrhage	1	2
Tapeworm Infection	1	2
Tuberculosis	1	2
Tuberculosis: Drug Resistant	1	2
Uterus: Contraction/Expulsion Disorders	1	2
Vaginal Atrophy	1	2
Wound Healing: Delayed	1	2
Adenoviridae Infections	1	1
Aflatoxicosis	1	1
Avian Influenza	1	1
Bacillus subtilis infections	1	1
Breast Cancer: Chemically-Induced	1	1
Breast Cancer: Estrogen	1	1
Breast Cancer: Metastatic	1	1
Breast Cancer: Prevention	1	1
Campylobacter Infections	1	1
Cancer Stem Cells	1	1
Candida Glabrata	1	1
Chemotherapy-Induced Kidney Damage	1	1
Cholera	1	1
Chronic Disease	1	1
Chronic Myeloid Leukemia	1	1
Clostridium Infections	1	1
Common Cold	1	1
Coronavirus Disease	1	1
Dental Caries	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Enterobacteriaceae Infections	1	1
Enveloped Viruses	1	1
Estrogen Dominance	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
H3N2 Infection	1	1
Helicobacter Pylori Infection	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
Herpes family viruses	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Infection: Antibiotic Resistant	1	1
MRSA	1	1
Mucositis	1	1
Mycotoxin Toxicity	1	1
Oral Candidosis	1	1
Oral Infection	1	1
Poxviruses	1	1
Pseudomonas Infections	1	1
SARS	1	1
Shigellosis	1	1
Skin Cancer	1	1
Squamous cell carcinoma	1	1
Staphylococcal Infections	1	1
Streptococcus pyogenes	1	1
Typhoid Fever	1	1
Vaccinia virus	1	1
Vibrio Infections	1	1
Viral Infections	1	1
Zika Virus	1	1

Name	AC	CK
Antioxidants	121	378
Anti-Inflammatory Agents	74	246
Antihypertensive Agents	10	94
Tumor Necrosis Factor (TNF) Alpha Inhibitor	18	70
Hypoglycemic Agents	15	66
Interleukin-6 Downregulation	14	65
Neuroprotective Agents	22	59
Cardioprotective	7	55
Malondialdehyde Down-regulation	11	53
Gastrointestinal Agents	8	49
Hypolipidemic	12	48
Hepatoprotective	22	44
Chemopreventive	21	43
Anti-Bacterial Agents	25	37
Anti-atherogenic	6	35
Renoprotective	16	30
Antiproliferative	25	29
NF-kappaB Inhibitor	11	29
Antimicrobial	16	28
Chemoprotective Agents	15	25
Apoptotic	15	22
Anti-Apoptotic	9	19
Insulin Sensitizers	3	18
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	16
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	16
Anti-metastatic	13	15
Anticarcinogenic Agents	7	14
Radioprotective	3	14
Cyclooxygenase 2 Inhibitors	8	12
Interleukin-1 beta downregulation	7	12
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	12
Photoprotective	2	12
Antifungal Agents	6	11
Antiviral Agents	11	11
Anti Inflammatory	1	10
Anti-collagenase	1	10
Anticholesteremic Agents	4	10
Cardiotonic Agents	1	10
Cardiovascular Agents	1	10
Cell cycle arrest	6	10
Cytoprotective	4	10
Ergogenic	1	10
Gastroprotective	6	10
Vasodilator Agents	1	10
anti-inflammatory	1	10
Chondroprotective	2	7
Prophylactic Agents	4	7
Anti-Fibrotic	4	6
Antidepressive Agents	3	6
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	6
Immunomodulatory	5	6
MicroRNA modulator	3	6
Tumor Suppressor Protein p53 Upregulation	4	6
Angiotensin-Converting Enzyme Inhibitors	3	5
Chemotherapeutic	5	5
Cyclin D1 Down-Regulation	3	5
Cytotoxic	1	5
Vasoprotective	2	5
Alpha-glucosidase inhibitor	4	4
Anti-Anxiety Agents	2	4
Anti-Ulcer Agents	2	4
Antimutagenic Agents	3	4
Antinoceceptive	2	4
Bax/Bcl2 ratio: Increase	3	4
Chemosensitizer	3	4
Interferon Gamma Reducer	2	4
Nrf2 activation	2	4
Osteoprotective	2	4
Angiogenesis Inhibitors	2	3
Anti-Infective Agents	2	3
Antineoplastic Agents	3	3
Antiparasitic Agents	2	3
Leishmanicidal	2	3
Prostaglandin PGE2 downregulation	2	3
Analgesics	1	2
Anti-Angiogenic	2	2
Antidiarrheals	1	2
Antimalarials	1	2
Antitubercular Agents	1	2
Aromatase Inhibitors	2	2
Bcl-2 protein down-regulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Caspase-3 Activation	1	2
Cholinesterase Inhibitors	1	2
Fertility Agents	1	2
Fertility Agents: Male	1	2
Genoprotective	1	2
Glutathione S-transferase Inhibitor	1	2
Heat Shock Protein Down-Regulation	1	2
Immunostimulatory	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Nitric Oxide Enhancer	1	2
Osteogenic	1	2
Pancreato Protective Agents	1	2
Regenerative	1	2
SGLT1 inducer	1	2
Selective estrogen enzyme modulator (SEEM)	2	2
Superoxide Dismutase Up-regulation	1	2
Uterotonic	1	2
Vascular Endothelial Growth Factor Inhibitors	2	2
Wnt/β-catenin signaling pathway modulation	2	2
apoptosis	1	2
Alpha-amylase inhibitor	1	1
Anti-Proliferative	1	1
Enzyme Inhibitors	1	1
Estrogen Receptor Modulators	1	1
Heme oxygenase-1 up-regulation	1	1
Nitric Oxide Inhibitor	1	1
P21 Activation	1	1
Selective Estrogen Receptor Modulators	1	1
Tyrosinase inhibitors	1	1
Viral Hemagglutinin Inhibitor	1	1

Pharmacological Actions : Antihypertensive Agents, Cardioprotective

Additional Keywords : Risk Reduction

[+]

4 weeks treatment with the pomegranate supplement significantly ameliorates the irritating symptoms of menopause.Jan 31, 2022

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Pubmed Data : Complement Ther Clin Pract. 2022 Feb ;46:101544. Epub 2022 Feb 2. PMID: 35134697

Article Published Date : Jan 31, 2022

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Menopausal Syndrome

[+]

A polyphenol-rich whole food supplement significantly effected the rate of PSA progression among men with prostate cancer.Mar 10, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Prostate Cancer Prostatic Dis. 2014 Mar 11. Epub 2014 Mar 11. PMID: 24614693

Article Published Date : Mar 10, 2014

Study Type : Human Study

Additional Links

Substances : Broccoli, Green Tea, Polyphenols, Pomegranate, Turmeric

Diseases : Prostate: PSA Doubling, Prostate Cancer

Additional Keywords : Supplements

[+]

A proprietary blend of standardized Punica granatum fruit rind and Theobroma cocoa seed extracts mitigates aging males' symptoms.Dec 31, 2021

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Pubmed Data : Int J Endocrinol Metab. 2016 Jan ;14(1):e33835. Epub 2016 Jan 30. PMID: 27279834

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Pubmed Data : Nutrition. 2015 Dec 7. Epub 2015 Dec 7. PMID: 26778544

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Pubmed Data : J Int Soc Sports Nutr. 2020 Mar 6 ;17(1):15. Epub 2020 Mar 6. PMID: 32143716

Article Published Date : Mar 05, 2020

Study Type : Human Study

Additional Links

Substances : Polyphenols, Pomegranate

Diseases : Athletic Performance

[+]

Efficacy of pomegranate seed powder on glucose and lipid metabolism in patients with type 2 diabetes.Dec 09, 2020

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Pubmed Data : Complement Med Res. 2020 Dec 10:1-8. Epub 2020 Dec 10. PMID: 33302270

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Pubmed Data : Mult Scler Relat Disord. 2021 Sep ;54:103103. Epub 2021 Jun 27. PMID: 34243101

Article Published Date : Aug 31, 2021

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Cognitive Decline/Dysfunction, Multiple Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

Human volunteers treated with pomegranate seed oil showed substantial amelioration of skin inflammation.Jan 15, 2023

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Pubmed Data : Front Nutr. 2022 ;9:1026343. Epub 2022 Oct 18. PMID: 36330147

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Asthma

Pharmacological Actions : Anti-Asthmatic Agents

[+]

Pomegranate extract consumption may reduce complications linked with obesity.Jan 31, 2016

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Pubmed Data : J Med Food. 2015 Mar 31. Epub 2015 Mar 31. PMID: 25826143

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Pubmed Data : Nutrients. 2017 Jul 29 ;9(8). Epub 2017 Jul 29. PMID: 28758938

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Pubmed Data : BMC Nutr. 2022 May 17 ;8(1):48. Epub 2022 May 17. PMID: 35581639

Article Published Date : May 16, 2022

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance

Therapeutic Actions : Exercise: Aerobic

Pharmacological Actions : Enzyme Inhibitors

[+]

Pomegranate juice intake had a significant beneficial effect, lowering systolic blood pressure and improving the lipid profiles of hemodialysis patients.Dec 31, 2013

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Pubmed Data : Nutr J. 2014 ;13:18. Epub 2014 Mar 4. PMID: 24593225

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Atherosclerosis, Cardiovascular Diseases, Hypertension, Kidney Failure, Oxidative Stress, Triglycerides: Elevated

Pharmacological Actions : Anti-atherogenic, Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Cardiovascular Agents

Additional Keywords : Phytotherapy

[+]

Pomegranate juice prolongs PSA doubling time, inhibits cell proliferation and increases apoptosis in men with prostate cancer. Feb 01, 2007

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Pubmed Data : Forsch Komplementmed. 2007 Feb;14(1):39-44. Epub 2007 Mar 6. PMID: 16818701

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Prostate: PSA Doubling, Prostate Cancer

[+]

Pomegranate juice significantly modulates matrix metalloproteinases 2 and 9 and serum levels of inflammatory factors protecting against exercise induced oxidative injury.Jun 30, 2014

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Pubmed Data : J Pak Med Assoc. 2014 Jul ;64(7):785-90. PMID: 25255587

Article Published Date : Jun 30, 2014

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Oxidative Stress

Pharmacological Actions : Anti Inflammatory, Antioxidants, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Phytotherapy, Prolonged Exercise

[+]

Pomegranate peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease.Aug 21, 2023

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Pubmed Data : Nutr J. 2023 Aug 22 ;22(1):40. Epub 2023 Aug 22. PMID: 37605174

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Pubmed Data : Altern Ther Health Med. 2017 Mar ;23(2):28-34. PMID: 28323626

Article Published Date : Feb 28, 2017

Study Type : Human Study

Additional Links

Substances : Pomegranate Seed

Diseases : Menopausal Syndrome

Additional Keywords : Plant Oils

[+]

Pomegranate supplementation accelerates recovery of muscle damage and soreness and inflammatory markers.Dec 31, 2015

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Pubmed Data : PLoS One. 2016 ;11(10):e0160305. Epub 2016 Aug 20. PMID: 27764091

Article Published Date : Dec 31, 2015

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Pubmed Data : Complement Ther Clin Pract. 2021 May ;43:101383. Epub 2021 Apr 2. PMID: 33862350

Article Published Date : Apr 30, 2021

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Pubmed Data : J Int Soc Sports Nutr. 2018 Jul 24 ;15(1):35. Epub 2018 Jul 24. PMID: 30041701

Article Published Date : Jul 23, 2018

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Oxidative Stress

Therapeutic Actions : Exercise

Pharmacological Actions : Antioxidants

[+]

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

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Pubmed Data : Atherosclerosis. 2014 Jan ;232(1):204-10. Epub 2013 Nov 19. PMID: 24401239

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Pubmed Data : Phytother Res. 2020 Aug 7. Epub 2020 Aug 7. PMID: 32767710

Article Published Date : Aug 06, 2020

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Cardiovascular Diseases, Polycystic Ovary Syndrome

Pharmacological Actions : Antihypertensive Agents

[+]

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Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2016 Sep 27. Epub 2016 Aug 27. PMID: 27697073

Article Published Date : Sep 26, 2016

Study Type : Human In Vitro

Additional Links

Substances : Pomegranate

Diseases : Lung Injury: Smoke-Induced, Tobacco Toxicity

Pharmacological Actions : Cytoprotective

[+]

The minimum inhibitory concentration of peel extract of Punica granatum approximated with that of the clotrimazole.Dec 31, 2016

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Adverse Pharmacological Actions : Nephrotoxic

[+]

A combination of black bean peel and pomegranate peel extracts, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress induced damage to the pancreas.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Pak Med Assoc. 2016 Jul ;66(7):859-63. PMID: 27427136

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

A nanoformulation of pomegranate seed oil can delay disease onset in a mouse model of genetic prion diseases.Jul 31, 2014

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Pubmed Data : Nanomedicine. 2014 Aug ;10(6):1353-63. Epub 2014 Apr 2. PMID: 24704590

Article Published Date : Jul 31, 2014

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Alzheimer's Disease, Creutzfeldt-Jakob disease, Lipid Peroxidation, Neurodegenerative Diseases, Prion Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

A polysaccharide from Punica granatum has an inhibitory effect on metastasis. May 24, 2017

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Pubmed Data : Int J Mol Sci. 2017 Dec 19 ;18(12). Epub 2017 Dec 19. PMID: 29257042

Article Published Date : Dec 18, 2017

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Depression: Postmenopausal

Pharmacological Actions : Antidepressive Agents

[+]

An ellagic acid enriched pomegranates extract promoted cholesterol removal by enhancing fecal bile acid.Feb 28, 2015

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Pubmed Data : Food Funct. 2015 Mar ;6(3):780-7. PMID: 25579987

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Pubmed Data : Nutrients. 2017 Apr 28 ;9(5). Epub 2017 Apr 28. PMID: 28452959

Article Published Date : Apr 27, 2017

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Breast Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation

[+]

Antinociceptive synergism of pomegranate peel extract and acetylsalicylic acid in an animal pain model.Sep 06, 2021

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Consumption of pomegranate peel extract may be effective in preventing the bone loss.Dec 31, 2014

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Pubmed Data : J Nutr Biochem. 2018 Dec 21 ;66:17-28. Epub 2018 Dec 21. PMID: 30708236

Evaluation of the effect of pomegranate seed oil on healing in a rat wound model.Aug 30, 2021

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Pubmed Data : Int J Low Extrem Wounds. 2021 Aug 31:15347346211040593. Epub 2021 Aug 31. PMID: 34463139

Article Published Date : Aug 30, 2021

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Wound Healing

Pharmacological Actions : Antioxidants

[+]

Evaluation of wound healing potential of pomegranate whole fruit extract on skin burn wounds.May 31, 2019

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Pubmed Data : J Adv Vet Anim Res. 2019 Jun ;6(2):202-207. Epub 2019 Apr 14. PMID: 31453192

Article Published Date : May 31, 2019

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Burns, Wound Healing

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antioxidants

[+]

Extracts of pomegranate peels and seeds have protective effects against liver fibrosis induced by carbon tetrachloride.Dec 31, 2014

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Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):389. Epub 2015 Oct 27. PMID: 26508316

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Pomegranate Peel, Pomegranate Seed

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Extracts rich in gallo- and ellagitannins act on different molecular targets in the protection against ulcerative colitis.Mar 28, 2016

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Pubmed Data : Mol Nutr Food Res. 2016 Mar 29. Epub 2016 Mar 29. PMID: 27028006

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Pubmed Data : Molecules. 2022 Jan 28 ;27(3). Epub 2022 Jan 28. PMID: 35164175

Article Published Date : Jan 27, 2022

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Encephalomyelitis, Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Hepatoprotective potential of pomegranate in curbing the incidence of acute liver injury.Dec 31, 2020

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Pubmed Data : Molecules. 2022 Feb 28 ;27(5). Epub 2022 Feb 28. PMID: 35268707

Article Published Date : Feb 27, 2022

Study Type : Animal Study

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Substances : Pomegranate

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin, Ehrlich carcinoma

Pharmacological Actions : Chemoprotective Agents, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis. Nov 01, 2010

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Pubmed Data : Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. Epub 2010 Oct 14. PMID: 20946358

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Pubmed Data : Rev Esp Cardiol (Engl Ed). 2015 Mar ;68(3):216-25. Epub 2014 Oct 23. PMID: 25444379

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Pubmed Data : Mol Med Rep. 2016 Mar 1. Epub 2016 Mar 1. PMID: 26936425

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Regenerative

[+]

Pomegranate extract alleviates hypertension by reducing oxidative stress and improving mitochondrial function. Oct 06, 2016

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Pubmed Data : Sci Rep. 2016 Oct 7 ;6:34246. Epub 2016 Aug 7. PMID: 27713551

Article Published Date : Oct 06, 2016

Study Type : Animal Study

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Substances : Pomegranate

Diseases : Hypertension, Oxidative Stress

Pharmacological Actions : Antihypertensive Agents, Antioxidants

[+]

Pomegranate extract ameliorates renal ischemia/reperfusion injury.Nov 30, 2021

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Pubmed Data : Hum Exp Toxicol. 2021 Dec ;40(12_suppl):S573-S582. Epub 2021 Nov 20. PMID: 34802289

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Ischemia, Kidney Damage

Pharmacological Actions : Renoprotective

[+]

pomegranate extract and beta-sitosterol may be a useful uterine stimulant.Mar 01, 2010

Pomegranate extract protects against alcohol and aspirin-induced gastric mucosal injury.Jan 04, 2005

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Pubmed Data : J Ethnopharmacol. 2005 Jan 4;96(1-2):171-6. PMID: 15588667

Article Published Date : Jan 04, 2005

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Alcohol Toxicity , Aspirin-Induced Toxicity , Gastric Ulcer, NSAID-induced toxicity , Oxidative Stress

Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Gastroprotective

Additional Keywords : Plant Extracts

[+]

Pomegranate extract reduced aortic sinus and coronary artery atherosclerosis in SR-BI/apoE dKO mice.Apr 30, 2013

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Pubmed Data : Atherosclerosis. 2013 May ;228(1):80-9. Epub 2013 Mar 7. PMID: 23528829

Article Published Date : Apr 30, 2013

Study Type : Animal Study

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Substances : Pomegranate

Diseases : Atherosclerosis, Clogged Arteries, Coronary Artery Disease

[+]

Pomegranate extracts and exercise may be additively effective in improving immune function in HFD-fed rats.Feb 27, 2016

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Pubmed Data : J Nutr Biochem. 2016 Feb 28 ;32:20-28. Epub 2016 Feb 28. PMID: 27142733

Article Published Date : Feb 27, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : High Fat Diet, Inflammation, Oxidative Stress

Therapeutic Actions : Exercise, Integrative Medicine

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts

[+]

Pomegranate extracts can accelerate the wound healing process.Feb 28, 2018

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Pubmed Data : Vet World. 2018 Mar ;11(3):321-326. Epub 2018 Mar 17. PMID: 29657424

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid, Pomegranate

Diseases : Wound Healing

[+]

Pomegranate extracts were effective in the treatment of drug induced nephrotoxicity.Oct 31, 2016

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Pubmed Data : Vet World. 2016 Nov ;9(11):1269-1274. Epub 2016 Nov 17. PMID: 27956780

Article Published Date : Oct 31, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Antibiotic Toxicity , Chemotherapy-Induced Toxicity: Gentamicin, Kidney Failure: Acute

Pharmacological Actions : Chemoprotective Agents, Renoprotective

Additional Keywords : Plant Extracts

[+]

Pomegranate flower polyphenols prevents high fat diet-induced obesity in Apo E-/- mice.Dec 31, 2016

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Pubmed Data : Cancer Res. 2007 Apr 1 ;67(7):3475-82. Epub 2007 Mar 27. PMID: 17389758

Article Published Date : Mar 31, 2007

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, NF-kappaB Inhibitor

Additional Keywords : Anticarcinogenic Agents, Chemopreventive, lung cancer, NF-kappaB Inhibitor, Phytotherapy, Plant Extracts, pomegranate

Problem Substances : Benzo(a)pyrene

[+]

Pomegranate fruit juice suppressed androgen dependent prostate carcinogenesis.Oct 03, 2014

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Pubmed Data : J Ethnopharmacol. 2004 May;92(1):93-101. PMID: 15099854

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Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease.Nov 30, 2006

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Pubmed Data : Neurobiol Dis. 2006 Dec ;24(3):506-15. Epub 2006 Sep 28. PMID: 17010630

Article Published Date : Nov 30, 2006

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Polyphenols, Pomegranate

Pharmacological Actions : Antioxidants

[+]

Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in a Parkinson's disease model. Apr 30, 2014

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Pubmed Data : Neurobiol Aging. 2014 May ;35(5):1162-76. Epub 2013 Oct 21. PMID: 24315037

Article Published Date : Apr 30, 2014

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Pomegranate juice extract ameliorated polycystic ovary syndrome accompanying endometrial histological alterations.May 18, 2021

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Pubmed Data : Morphologie. 2021 May 19. Epub 2021 May 19. PMID: 34023214

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Pubmed Data : Int J Nanomedicine. 2019 ;14:8905-8922. Epub 2019 Nov 15. PMID: 31814719

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Pubmed Data : Prev Nutr Food Sci. 2016 Mar ;21(1):14-23. Epub 2016 Mar 31. PMID: 27069901

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats. Sep 01, 2007

Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury.Dec 31, 2006

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Pubmed Data : Dev Neurosci. 2007 ;29(4-5):363-72. PMID: 17762204

Pomegranate seed oil demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury.Nov 30, 2018

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Pubmed Data : Iran J Basic Med Sci. 2018 Dec ;21(12):1262-1268. PMID: 30627370

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Pomegranate Seed

Diseases : Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Pomegranate seed oil extract has therapeutic effects on osteoporosis.Dec 31, 2016

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Pubmed Data : J Nutr Health Aging. 2017 ;21(10):1299-1306. PMID: 29188893

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Pubmed Data : Avicenna J Phytomed. 2017 Jul-Aug;7(4):317-333. PMID: 28884082

Punica granatum peel extract modulates levofloxacin-induced oxidative stress and testicular damage.Nov 30, 2023

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Pubmed Data : Tissue Cell. 2023 Dec ;85:102227. Epub 2023 Sep 27. PMID: 37793207

Article Published Date : Nov 30, 2023

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Antibiotic Toxicity , Oxidative Stress, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

Problem Substances : Antibiotics

[+]

Punica granatum peel extract pre-treatment alleviates fenpropathrin-induced testicular injury.Jun 02, 2023

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Pubmed Data : J Med Food. 2011 Jul-Aug;14(7-8):695-701. Epub 2011 Jun 1. PMID: 21631359

Article Published Date : Jun 30, 2011

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Brain: Oxidative Stress, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords :

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View the Evidence: 535 Abstracts with Pomegranate Research

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The effects of pomegranate consumption on inflammatory and oxidative stress.Sep 30, 2023

The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction.Feb 29, 2020

The present meta-analysis suggests consistent benefits of pomegranate juice consumption on blood pressure.Nov 22, 2016

This review provides support for the use of polyphenol-rich interventions for improving cardiovascular risk markers in haemodialysis patients.Dec 10, 2017

4 weeks treatment with the pomegranate supplement significantly ameliorates the irritating symptoms of menopause.Jan 31, 2022

A polyphenol-rich whole food supplement significantly effected the rate of PSA progression among men with prostate cancer.Mar 10, 2014

A proprietary blend of standardized Punica granatum fruit rind and Theobroma cocoa seed extracts mitigates aging males' symptoms.Dec 31, 2021

Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients.Jul 31, 2023

Antenatal intake of pomegranate may limit placental injury and thereby may confer protection to the exposed fetus.Feb 28, 2012

Comparison of antifungal efficacy of ethanolic extracts of Woodfordia fruticosa leaf and Punica granatum peel in uncontrolled diabetic patients wearing removable dentures.Aug 31, 2020

Concentrated pomegranate juice appeared to have favourable effects on certain markers of subclinical inflammation in diabetic patients.Dec 31, 2015

Concentrated pomegranate juice could effectively improve testosterone levels in overweight and obese women with polycystic ovary syndrome.May 31, 2023

Consuming daily synbiotic pomegranate juice improved metabolic, oxidative, inflammatory, and blood pressure outcomes in females with PCOS.Nov 10, 2019

Consumption of fruits that are high in antioxidants could represent a useful means to improve the antioxidant status of NAFLD.Jul 13, 2016

Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia.May 16, 2018

Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis.Aug 01, 2011

Consumption of pomegranate extract decreased endotoxemia in overweight-obese individuals by reshaping the gut microbiota.May 31, 2018

Consumption of pomegranate juice improved MDA levels and carbonyls, and thus decreased the oxidative damage caused by exercise.Dec 06, 2015

Consumption of pomegranate peel extract in combination with vitamin E enhanced the inflammatory status and endothelial function in hemodialysis patients.Aug 24, 2020

Consumption of watermelon juice enriched in I-citrulline and pomegranate ellagitannins enhanced metabolism during physical exercise.Jun 06, 2017

Daily consumption of pomegranate juice may stabilize the ability to learn visual information over a 12-month period.Nov 11, 2019

Daily oral pomegranate consumption may lead to enhanced protection from ultraviolet photodamage.Oct 09, 2019

Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises.Mar 05, 2020

Efficacy of pomegranate seed powder on glucose and lipid metabolism in patients with type 2 diabetes.Dec 09, 2020

Extracts of gotu kola and pomegranate improve clinical symptoms of chronic periodontitis. Jul 01, 2005

Fresh pomegranate juice decreases fasting serum erythropoietin in patients with type 2 diabetes.Dec 31, 2018

GranaGard administration to MS patients might improve/stabilize cognitive disability.Aug 31, 2021

Human volunteers treated with pomegranate seed oil showed substantial amelioration of skin inflammation.Jan 15, 2023

in the form of a new beverage can improve insulin resistance, insulin, testosterone level, BMI, weight and waist circumference in PCOS. Dec 31, 2018

In UA producers, the genera Butyrivibrio, Enterobacter, Escherichia, Lactobacillus, Prevotella, Serratia and Veillonella were increased and Collinsella decreased significantly at week 4 compared to baseline.Jul 19, 2015

Optimized curcumin, pomegranate extract, and methylsulfonylmethane reduce acute, systemic inflammatory response to a half-marathon race. Jun 30, 2020

Pharmacological therapy determines the gut microbiota modulation by a pomegranate extract nutraceutical in metabolic syndrome.Dec 21, 2021

Polyphenol and methylsulfonylmethane supplementation improves immune, DAMP signaling, and inflammatory responses during recovery from all-out running efforts.Dec 31, 2020

Polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus.Feb 10, 2022

Pomegranate and chamomile plant extracts had antimicrobial and anti-inflammatory properties similar to that of chlorhexidine 0.12%.Jan 31, 2014

Pomegranate and licorice drinks could increase the metabolism rate for nicotine.Sep 27, 2016

Pomegranate consumption can improve physical function and stiffness, decrease breakdown cartilage enzymes and increase antioxidant status.Jan 24, 2016

Pomegranate extract can ameliorate some clinical symptoms and reduce neutrophils, basophils, and eosinophils in allergic asthma patients.Dec 31, 2022

Pomegranate extract can improve lung function parameters and IL-35 expression in mild and moderate allergic asthma.Dec 31, 2021

Pomegranate extract consumption may reduce complications linked with obesity.Jan 31, 2016

Pomegranate extract may be effective in improving performance outcomes at maximal effort and might help to restore force in the damaged muscles.Mar 27, 2019

Pomegranate extract supplementation enhanced vessel diameter and blood flow, suggesting possible exercise performance enhancement.Mar 31, 2017

Pomegranate extract supplementation may reduce BP and increase the antioxidant activity in HD patients.Mar 30, 2015

Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints.Dec 31, 2012

Pomegranate juice confers a lower glycemic response on a high-glycemic index food.Oct 10, 2017

Pomegranate juice consumption appears to slow the progression of the carotid intima-media thickness in subjects with increased oxidative stress and poor blood lipid profiles. Oct 01, 2009

Pomegranate juice consumption could decrease systolic and diastolic blood pressure in patients with diabetes.Jan 31, 2019

Pomegranate juice consumption has potential anti-inflammatory and cardio-protective effects.Jul 31, 2016

Pomegranate juice consumption may delay onset of T2D complications related to oxidative stress.Dec 31, 2014

Pomegranate juice could attenuate oxidative stress following an intensive weightlifting training session.Jul 28, 2017

Pomegranate juice could have favourable effects on oxidative stress in patients with type 2 diabetes.Sep 15, 2016

Pomegranate juice had beneficial effects on hormonal biomarkers of breast cancer risk in this preliminary study.Sep 30, 2015

Pomegranate juice has potent antiatherogenic effects in healthy humans and in atherosclerotic mice that may be attributable to its antioxidative properties.May 01, 2000

Pomegranate juice improves the cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients.Oct 22, 2019

Pomegranate juice increases sirtuin1 protein in peripheral blood mononuclear cell from patients with type 2 diabetes.Jun 28, 2018

Pomegranate juice intake enhances the effects of aerobic training on insulin resistance and liver enzymes in type 2 diabetic men.May 16, 2022

Pomegranate juice intake had a significant beneficial effect, lowering systolic blood pressure and improving the lipid profiles of hemodialysis patients.Dec 31, 2013

Pomegranate juice prolongs PSA doubling time, inhibits cell proliferation and increases apoptosis in men with prostate cancer. Feb 01, 2007

Pomegranate juice significantly modulates matrix metalloproteinases 2 and 9 and serum levels of inflammatory factors protecting against exercise induced oxidative injury.Jun 30, 2014

Pomegranate peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease.Aug 21, 2023

Pomegranate peel extract seems effective in complementary management of ulcerative colitis.Jul 31, 2015

Pomegranate polyphenols enhanced cognitive and functional recovery after stroke.Feb 12, 2018

Pomegranate reduces the intima media thickness size of the artery, while also reducing blood pressure and LDL oxidation.Jun 01, 2004

Pomegranate seed oil increased the GLUT-4 gene expression in diabetic patients without any side effects.Apr 02, 2019

Pomegranate seed oil influenced significant improvements in patients with menopausal symptoms. Feb 28, 2017

Pomegranate supplementation accelerates recovery of muscle damage and soreness and inflammatory markers.Dec 31, 2015

POMx alleviates disease activity and improves some blood biomarkers of inflammation and oxidative stress in rheumatoid arthritis patients.Aug 30, 2016

POMx treatment significantly increased the PSA doubling time by over 6 months in both treatment arms.May 19, 2011

POMx treatment significantly increased the PSA doubling time by over 6 months in men with prostate cancer. Feb 28, 2011

Protective effect of Punica granatum extract in head and neck cancer patients undergoing radiotherapy.Sep 30, 2019

Punica granatum peel extract as adjunct irrigation to nonsurgical treatment of chronic gingivitis.Apr 30, 2021

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View the Evidence:
535 Abstracts with Pomegranate Research