Poria cocos

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7 Diseases Researched for Poria cocos
NameACCKFocus
Progesterone: Low12Locked
Alzheimer's Disease11Locked
Breast Cancer11Locked
Cancer Metastasis11Locked
Cancers: All11Locked
Neurodegenerative Diseases11Locked
Oxidative Stress11Locked
7 Pharmacological Actions Researched for Poria cocos
NameACCKFocus
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Secretagogue12Locked
Anti-Apoptotic11Locked
Anti-metastatic11Locked
Antioxidants11Locked
NF-kappaB Inhibitor11Locked
Neuroprotective Agents11Locked
Related Topics

Poria cocos is a Sub of the following Topic

View the Evidence:
32 Abstracts with Poria cocos Research

[+]

16α-hydroxytrametenolic acid from Poria cocos improves intestinal barrier function.Oct 01, 2019

Pubmed Data : J Agric Food Chem. 2019 Oct 2 ;67(39):10871-10879. Epub 2019 Sep 23. PMID: 31517482
Article Published Date : Oct 01, 2019
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Gastrointestinal Diseases, Gastrointestinal Inflammation, Irritable Bowel Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

A mixture of asian herbs increases progesterone secretion in female rats.Jan 01, 1991

Pubmed Data : Am J Chin Med. 1991;19(1):57-60. PMID: 1897491
Article Published Date : Jan 01, 1991
Study Type : Animal Study
Additional Links
Substances : Angelica, Cnidium , Peony, Poria cocos
Diseases : Progesterone: Low
Pharmacological Actions : Secretagogue
[+]

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

Pubmed Data : J Cell Biochem. 2019 May ;120(5):7482-7488. Epub 2018 Oct 30. PMID: 30378160
Article Published Date : Apr 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Effect of Poria cocos hydroethanolic extract on treating adriamycin-induced rat model of nephrotic syndrome.Nov 30, 2017

Pubmed Data : Chin J Integr Med. 2017 Dec ;23(12):916-922. Epub 2016 Dec 29. PMID: 28035538
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.Jul 14, 2018

Pubmed Data : Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139
Article Published Date : Jul 14, 2018
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Polysaccharides
Problem Substances : Acetaminophen, Paracetamol
[+]

Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-κB signaling in vitro and in vivo.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Apr ;112:108709. Epub 2019 Mar 1. PMID: 30970514
Article Published Date : Mar 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Lung Cancer
Pharmacological Actions : Antineoplastic Agents, NF-kappaB Inhibitor
[+]

P. cocos may be considered as a traditional herbal potential medicine for the treatment of depression.Jan 08, 2020

Pubmed Data : J Ethnopharmacol. 2020 Jan 9. Epub 2020 Jan 9. PMID: 31926986
Article Published Date : Jan 08, 2020
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms, Poria cocos
Diseases : Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

P. cocos modulates gut microbiota to improve hyperglycemia and hyperlipidemia.Dec 31, 2018

Pubmed Data : Chin J Nat Med. 2019 Jan ;17(1):3-14. PMID: 30704621
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Fatty Liver, Hepatic Steatosis, Hyperglycemia, Hyperlipidemia
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Polysaccharides
[+]

Poria cocos bark extract has potential as an oral immune suppressor for the treatment of atopic dermatitis and food allergy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2016 ;2016:3472608. Epub 2016 Jun 29. PMID: 27445434
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Atopic Dermatitis, Female, Food Allergies
Pharmacological Actions : Immunomodulatory, Immunosuppressive Agents
Additional Keywords : Plant Extracts
[+]

The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism.Nov 13, 2018

Pubmed Data : Food Funct. 2018 Nov 14 ;9(11):5936-5949. PMID: 30378628
Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation
Additional Keywords : Polysaccharides
[+]

Total triterpenes extracted from P. cocos possessed potential antiepileptic properties.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2016 Nov ;54(11):2528-2535. Epub 2016 May 9. PMID: 27159135
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury.Jul 08, 2013

Pubmed Data : J Ethnopharmacol. 2013 Jul 9 ;148(2):403-10. Epub 2013 Apr 21. PMID: 23612421
Article Published Date : Jul 08, 2013
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Chronic Kidney Disease (CKD)
Pharmacological Actions : Renoprotective
[+]

Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos.Nov 30, 2018

Pubmed Data : Int J Biol Macromol. 2018 Dec ;120(Pt B):1696-1704. Epub 2018 Sep 26. PMID: 30267822
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Immunosuppressive Agents, Neuroprotective Agents
[+]

Antioxidant property of water-soluble polysaccharides from Poria cocos Wolf using different extraction methods.Jan 31, 2016

Pubmed Data : Int J Biol Macromol. 2016 Feb ;83:103-10. Epub 2015 Nov 19. PMID: 26601761
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Polysaccharides
[+]

Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.Dec 31, 2016

Pubmed Data : Bioorg Chem. 2017 02 ;70:94-99. Epub 2016 Nov 23. PMID: 27912907
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Co-delivery of Poria cocos extract and doxorubicin as an 'all-in-one' nanocarrier to combat breast cancer multidrug resistance during chemotherapy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nanomedicine. 2020 Jan ;23:102095. Epub 2019 Oct 25. PMID: 31669856
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Breast Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Coconut water extract protects neuronal cells from beta amyloid-induced cell death through antioxidant and antiapoptic funtions.Nov 01, 2009

Pubmed Data : Pharmazie. 2009 Nov;64(11):760-4. PMID: 20099523
Article Published Date : Nov 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Cytotoxic constituents from the sclerotia of Poria cocos against human lung adenocarcinoma cells by inducing mitochondrial apoptosis.Aug 23, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2018 Aug 24 ;7(9). Epub 2018 Aug 24. PMID: 30149516
Article Published Date : Aug 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic
[+]

Hepatoprotective activity of an herbal composition, MAP, a standardized blend comprising Myristica fragrans, Astragalus membranaceus, and Poria cocos.Sep 30, 2016

Pubmed Data : J Med Food. 2016 Oct ;19(10):952-960. Epub 2016 Aug 26. PMID: 27564381
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Astragalus, Nutmeg, Poria cocos
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Induction of apoptosis by an ethanol extract of Poria cocos Wolf. in human leukemia U937 cells.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2015 Nov ;34(5):2533-40. Epub 2015 Sep 8. PMID: 26353048
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Lymphoma
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Isolation of homogeneous polysaccharide from Poria cocos and effect of its sulfated derivatives on migration of human breast cancer MDA-MB-231 cells.Jun 30, 2019

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2019 Jul ;44(13):2835-2840. PMID: 31359698
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Polysaccharides
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Medical mushrooms and phytochemicals represent useful approaches to target tissue invasion and metastasis as well as other hallmark areas of cancer.Apr 08, 2015

Pubmed Data : Semin Cancer Biol. 2015 Apr 9. Epub 2015 Apr 9. PMID: 25865774
Article Published Date : Apr 08, 2015
Study Type : Review
Additional Links
Substances : Agaricus Blazei, Cordyceps Militaris, Medicinal Mushrooms, Milk Thistle, Poria cocos, Reishi Mushroom
Diseases : Cancer Metastasis, Cancers: All
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Molecular basis for Poria cocos mushroom polysaccharide used as an antitumor drug in China.Dec 31, 2018

Pubmed Data : Prog Mol Biol Transl Sci. 2019 ;163:263-296. Epub 2019 Apr 1. PMID: 31030751
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Poria cocos
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
Additional Keywords : Polysaccharides
[+]

Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 01 ;23(1):4-20. Epub 2018 Nov 15. PMID: 30444050
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Poria cocos
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic, Immunomodulatory
Additional Keywords : Polysaccharides
[+]

Molecular mechanism of Poria cocos combined with oxaliplatin on the inhibition of epithelial-mesenchymal transition in gastric cancer cells.May 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun ;102:865-873. Epub 2018 Apr 5. PMID: 29710543
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Cancer Metastasis, Gastric Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

P. cocos is a traditional herbal medicine for treatment of inflammation and its associated disorders.Mar 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 Mar 15 ;14:101. Epub 2014 Mar 15. PMID: 24628870
Article Published Date : Mar 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy
[+]

Pachymic acid, a triterpenoid derived from coconut, impairs breast cancer cell invasion.Jun 03, 2010

Pubmed Data : Breast Cancer Res Treat. 2010 Jun 3. Epub 2010 Jun 3. PMID: 20521099
Article Published Date : Jun 03, 2010
Study Type : In Vitro Study
Additional Links
Substances : Pachymic acid, Poria cocos
Diseases : Breast Cancer
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Poria cocos polysaccharides may be a promising candidate for the therapy of atherosclerosis.Jan 12, 2020

Pubmed Data : Int Immunopharmacol. 2020 Jan 13 ;80:106173. Epub 2020 Jan 13. PMID: 31945610
Article Published Date : Jan 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Protective effect of lanostane triterpenoids from the sclerotia of Poria cocos Wolf against cisplatin-induced apoptosis in LLC-PK1 cells.Dec 31, 2016

Pubmed Data : Bioorg Med Chem Lett. 2017 07 1 ;27(13):2881-2885. Epub 2017 Apr 27. PMID: 28487074
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca2+/PKC/p38/NF-κB signaling pathway in macrophages.Jun 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:252-257. Epub 2019 Apr 16. PMID: 31003002
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Immunomodulatory
Additional Keywords : Polysaccharides
[+]

This suggested that Poria cocos Wolf can be potentially used for the treatment of hepatic steatosis.Sep 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Sep 27 ;20(19). Epub 2019 Sep 27. PMID: 31569635
Article Published Date : Sep 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Hepatic Steatosis
Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective, Hypolipidemic
[+]

Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.May 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2013 Jun ;42(6):1869-74. Epub 2013 Apr 16. PMID: 23588713
Article Published Date : May 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix Metalloproteinase-7 (MMP-7) Inhibitor

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