Poria cocos

Name	AC	CK
Diabetes Mellitus: Type 2	1	21
Inflammation	11	15
Sleep Disorders	2	12
Gastric Cancer	6	8
Depression	4	7
Hyperlipidemia	3	7
Lipopolysaccharide-Induced Toxicity	6	7
Chemotherapy-Induced Toxicity: Doxorubicin	3	6
Diarrhea: Antibiotic-Associated	3	6
Oxidative Stress	5	6
Alzheimer's Disease	3	5
Lung Cancer	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Aging	2	4
Breast Cancer	4	4
Chronic Kidney Disease (CKD)	2	4
Fatty Liver	2	4
Hepatic Steatosis	3	4
High Fat Diet	2	4
Kidney Cancer	2	4
Kidney Damage	2	4
Kidney Fibrosis	2	4
Liver Damage: Drug-Induced	2	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Sepsis	2	4
Acute lymphoblastic leukemia (ALL)	1	3
Alcoholic Liver Disease	2	3
Brain Ischemia	2	3
Cancer Metastasis	3	3
Cancers: All	3	3
Chemotherapy-Induced Kidney Damage	2	3
Diabetic Nephropathy	2	3
Irritable Bowel Syndrome	2	3
Liver Cancer	3	3
Myocardial Infarction	2	3
Neurodegenerative Diseases	2	3
Aluminum Toxicity	1	2
Androgenic Alopecia	1	2
Anxiety	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Bacterial Prostatitis	1	2
Cardiomegaly	1	2
Cervical Cancer	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Colitis	1	2
Dyspepsia	1	2
Epilepsy	1	2
Female	1	2
Fibrosis	1	2
Food Allergies	1	2
Gastrointestinal Complaints	1	2
Gastrointestinal Diseases	1	2
Gastrointestinal Inflammation	1	2
Heart Failure	1	2
Hemorrhagic Shock	1	2
Hyperglycemia	1	2
Hypertension: Pulmonary	1	2
Inflammatory Bowel Diseases	1	2
Insomnia	1	2
Kidney Damage: Drug-Induced	1	2
Lead Poisoning	1	2
Liver Injury: Ischemia/reperfusion	1	2
Lung Damage	1	2
Myocardial Ischemia	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Obesity	1	2
Osteoarthritis	1	2
Pancreatic Cancer	2	2
Pneumonia	1	2
Polycystic Ovary Syndrome	1	2
Progesterone: Low	1	2
Prostatitis: Chronic	1	2
Ulcerative Colitis	1	2
Adenoviridae Infections	1	1
Atherosclerosis	1	1
Bladder Cancer	1	1
Breast Cancer: Triple Negative	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Chemically-Induced Liver Damage	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cognitive Decline/Dysfunction	1	1
Coronavirus Disease (Covid-19)	1	1
Coronavirus Infection	1	1
Covid: Long	1	1
Gallbladder Cancer	1	1
HIV Infections	1	1
Hyperuricemia	1	1
Hypoglycemia	1	1
Influenza	1	1
Lymphoma	1	1
Nasopharyngeal Cancer	1	1
Ovarian Cancer	1	1
Pancreatic Fibrosis	1	1
Rhinovirus Infection	1	1
Wound Healing	1	1

Name	AC	CK
Anti-Inflammatory Agents	35	57
Hypoglycemic Agents	3	24
Gastrointestinal Agents	12	23
NF-kappaB Inhibitor	12	21
Apoptotic	15	20
Tumor Necrosis Factor (TNF) Alpha Inhibitor	11	18
Hepatoprotective	10	17
Anti-Apoptotic	10	16
Antioxidants	11	15
Renoprotective	8	14
Antiproliferative	11	13
Anti-Fibrotic	6	11
Anti-metastatic	9	11
Chemoprotective Agents	6	11
Cardioprotective	6	10
Hypolipidemic	5	10
Immunomodulatory	8	10
Interleukin-1 beta downregulation	6	10
Interleukin-6 Downregulation	6	10
Neuroprotective Agents	6	9
Antidepressive Agents	4	7
Nrf2 activation	3	5
Antineoplastic Agents	3	4
Autophagy Up-regulation	3	4
Cell cycle arrest	2	4
Gastroprotective	2	4
Malondialdehyde Down-regulation	2	4
Cyclooxygenase 2 Inhibitors	3	3
Heme oxygenase-1 up-regulation	2	3
Immunosuppressive Agents	2	3
Anti-Anxiety Agents	1	2
Anti-Asthmatic Agents	1	2
Anticonvulsants	1	2
Antihypertensive Agents	1	2
Chelating Agents	1	2
Chemopreventive	2	2
Interleukin-10 upregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-5 downregulation	1	2
Interleukin-8 downregulation	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	2
Prophylactic Agents	1	2
Secretagogue	1	2
Superoxide Dismutase Up-regulation	1	2
Alpha-glucosidase inhibitor	1	1
Angiogenesis Inducing Agents	1	1
Angiogenesis Inhibitors	1	1
Bcl-2 protein down-regulation	1	1
Chemosensitizer	1	1
Chemotherapeutic	1	1
Heat Shock Protein Inducer	1	1
Immunostimulatory	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Neurogenesis	1	1
Pancreato Protective Agents	1	1
Postaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Uricosuric Agents	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1

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Benefits of herbal formulae containing Poria cocos for type 2 diabetes mellitus.Dec 31, 2021

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Pubmed Data : Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139

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Pubmed Data : J Ethnopharmacol. 2020 Jan 9. Epub 2020 Jan 9. PMID: 31926986

Article Published Date : Jan 08, 2020

Study Type : Animal Study

Additional Links

Substances : Medicinal Mushrooms, Poria cocos

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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P. cocos modulates gut microbiota to improve hyperglycemia and hyperlipidemia.Dec 31, 2018

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Pubmed Data : Chin J Nat Med. 2019 Jan ;17(1):3-14. PMID: 30704621

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Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Polysaccharides

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Poria cocos polysaccharides rescue pyroptosis-driven gut vascular barrier disruption in order to alleviates non-alcoholic steatohepatitis.Oct 04, 2022

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Pubmed Data : J Ethnopharmacol. 2022 Oct 5 ;296:115457. Epub 2022 Jun 23. PMID: 35753609

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Pubmed Data : Food Funct. 2018 Nov 14 ;9(11):5936-5949. PMID: 30378628

Article Published Date : Nov 13, 2018

Study Type : Animal Study

Additional Links

Substances : Poria cocos

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation

Additional Keywords : Polysaccharides

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Total triterpenes extracted from P. cocos possessed potential antiepileptic properties.Oct 31, 2016

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Pubmed Data : Pharm Biol. 2016 Nov ;54(11):2528-2535. Epub 2016 May 9. PMID: 27159135

Article Published Date : Oct 31, 2016

Study Type : Animal Study

Additional Links

Substances : Poria cocos

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

Additional Keywords : Plant Extracts

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Pubmed Data : Ultrastruct Pathol. 2017 ;41(3):245-251. Epub 2017 Apr 17. PMID: 28414554

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

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Coconut water extract protects neuronal cells from beta amyloid-induced cell death through antioxidant and antiapoptic funtions.Nov 01, 2009

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Pubmed Data : Pharmazie. 2009 Nov;64(11):760-4. PMID: 20099523

Article Published Date : Nov 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Cytotoxic constituents from the sclerotia of Poria cocos against human lung adenocarcinoma cells by inducing mitochondrial apoptosis.Aug 23, 2018

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2019 Jul ;44(13):2835-2840. PMID: 31359698

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Pubmed Data : Semin Cancer Biol. 2015 Apr 9. Epub 2015 Apr 9. PMID: 25865774

Article Published Date : Apr 08, 2015

Study Type : Review

Additional Links

Substances : Agaricus Blazei, Cordyceps Militaris, Medicinal Mushrooms, Milk Thistle, Poria cocos, Reishi Mushroom

Diseases : Cancer Metastasis, Cancers: All

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Molecular basis for Poria cocos mushroom polysaccharide used as an antitumor drug in China.Dec 31, 2018

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Pubmed Data : Prog Mol Biol Transl Sci. 2019 ;163:263-296. Epub 2019 Apr 1. PMID: 31030751

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Substances : Poria cocos

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Polysaccharides

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Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China.Dec 31, 2018

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Pubmed Data : Tissue Cell. 2024 Jun ;88:102401. Epub 2024 May 3. PMID: 38749116

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Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:252-257. Epub 2019 Apr 16. PMID: 31003002

Article Published Date : Jun 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Immunomodulatory

Additional Keywords : Polysaccharides

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The lanostane triterpenoids in Poria cocos play beneficial roles in immunoregulatory activity.Jan 31, 2021

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Pubmed Data : Int J Oncol. 2013 Jun ;42(6):1869-74. Epub 2013 Apr 16. PMID: 23588713

Article Published Date : May 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Pancreatic Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix Metalloproteinase-7 (MMP-7) Inhibitor

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View the Evidence: 117 Abstracts with Poria cocos Research

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Benefits of herbal formulae containing Poria cocos for type 2 diabetes mellitus.Dec 31, 2021

Efficacy of Poria cocos extract on sleep quality enhancement.Sep 30, 2023

Pachymic acid inhibits growth and induces cell cycle arrest and apoptosis in gastric cancer SGC-7901 cells.Jul 31, 2018

Poria acid inhibit the growth and metastasis of renal cell carcinoma.May 29, 2024

Poricoic acid A (PAA) inhibits T-cell acute lymphoblastic leukemia through inducing autophagic cell death and ferroptosis.Jun 10, 2022

The anti-hyperlipidemic effects of Poria cocos (Schw.) Wolf extract: modulating cholesterol homeostasis in hepatocytes.Feb 29, 2024

16α-hydroxytrametenolic acid from Poria cocos improves intestinal barrier function.Oct 01, 2019

A mixture of asian herbs increases progesterone secretion in female rats.Jan 01, 1991

Alleviation of androgenetic alopecia with aqueous Paeonia lactiflora and Poria cocos extract.Nov 04, 2021

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

Antitumor activity of pachymic acid in cervical cancer.Aug 31, 2022

Effect and mechanism of Poria cocos polysaccharides on myocardial cell apoptosis in rats with myocardial ischemia-reperfusion injury.Nov 30, 2023

Effect of Poria cocos hydroethanolic extract on treating adriamycin-induced rat model of nephrotic syndrome.Nov 30, 2017

Effects of Poria cocos extract and protein powder mixture on glucolipid metabolism and rhythm changes in obese mice.Apr 30, 2023

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease.Dec 31, 2021

Efficacy of Poria cocos and Alismatis rhizoma against diet-induced hyperlipidemia.Oct 14, 2023

Extracts of Poria cocos improve functional dyspepsia via regulating brain-gut peptides, immunity and repairing of gastrointestinal mucosa.Dec 31, 2021

Extracts of Poria cocos polysaccharides improves alcoholic liver disease.Dec 31, 2021

Garlic and Fu-ling play a role in mitigating the toxicity of lead in grass carp.Jun 30, 2021

Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.Jul 14, 2018

Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-κB signaling in vitro and in vivo.Mar 31, 2019

Metabolites of gut microbiota fermenting Poria cocos polysaccharide alleviates chronic nonbacterial prostatitis.Apr 07, 2022

Neuroprotective effects of Poria cocos essential oil on Aβ1-40-induced learning and memory deficits.Dec 31, 2021

P. cocos extract remodels the intrinsic Th1/Th2 response to prevent or alleviate allergy-induced asthma or symptoms.Apr 20, 2021

P. cocos may be considered as a traditional herbal potential medicine for the treatment of depression.Jan 08, 2020

P. cocos modulates gut microbiota to improve hyperglycemia and hyperlipidemia.Dec 31, 2018

Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis.May 09, 2023

Pachymic acid ameliorates pulmonary hypertension.Jan 31, 2022

Pachymic acid ameliorates sepsis-induced acute kidney injury.Mar 31, 2017

Pachymic acid attenuated doxorubicin-induced heart failure.Oct 01, 2021

Pachymic acid improves survival and attenuates acute lung injury in sepsis.Mar 31, 2017

Pachymic acid inhibits ferroptosis of cardiomyocytes.Sep 25, 2023

Pachymic acid inhibits inflammation and cell apoptosis in lipopolysaccharide (LPS)-induced model with pneumonia.Dec 31, 2020

Pachymic acid prevents hemorrhagic shock-induced cardiac injury.Dec 31, 2022

Pachymic acid promotes induction of autophagy related to IGF-1 signaling pathway in WI-38 cells.Nov 30, 2017

Pachymic acid protects against bleomycin-induced pulmonary fibrosis.Aug 30, 2023

Pachymic acid protects against cerebral ischemia/reperfusion injury.Mar 31, 2020

Pachymic acid protects against Crohn's disease-like intestinal barrier injury and colitis.Jun 19, 2023

Pachymic acid protects hepatic cells against oxygen-glucose deprivation/reperfusion injury.Dec 31, 2022

Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome.Oct 28, 2020

Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis.Aug 29, 2023

Poria cocos bark extract has potential as an oral immune suppressor for the treatment of atopic dermatitis and food allergy.Dec 31, 2015

Poria cocos polysaccharide alleviates dextran sulphate sodium-induced ulcerative colitis.Nov 30, 2024

Poria cocos polysaccharide ameliorated antibiotic-associated diarrhea.Jan 10, 2023

Poria cocos polysaccharide attenuates damage of nervus in Alzheimer's disease.Jan 18, 2021

Poria cocos polysaccharide improves intestinal barrier function and maintains intestinal homeostasis.Sep 29, 2023

Poria cocos polysaccharides attenuate chronic nonbacterial prostatitis by targeting the gut microbiota.Oct 30, 2021

Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU.Oct 02, 2022

Poria cocos polysaccharides rescue pyroptosis-driven gut vascular barrier disruption in order to alleviates non-alcoholic steatohepatitis.Oct 04, 2022

Poria cocos triterpenoids extract promotes collagen and hyaluronic acid production in D-galactose-induced aging rats.Oct 27, 2023

Poria cocos water-soluble polysaccharide modulates anxiety-like behavior induced by sleep deprivatio.Jun 19, 2022

Poricoic acid A attenuates renal fibrosis by inhibiting endoplasmic reticulum stress-mediated apoptosis.Dec 31, 2023

Poricoic acid A induces mitophagy to ameliorate podocyte injury in diabetic kidney disease.Sep 13, 2023

Poricoic acid A inhibits the NF- κ B/MAPK pathway to alleviate renal fibrosis.Dec 31, 2021

Poricoic acid A suppresses renal fibroblast activation and interstitial fibrosis.Apr 30, 2023

Potential therapeutic efficacy of pachymic acid in chronic kidney disease.Jan 04, 2022

Probiotic powder with polysaccharides from Wolfiporia cocos alleviates antibiotic-associated diarrhea.Nov 30, 2024

Regulation of gut microbiota and intestinal metabolites by Poria cocos oligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fed mice.Aug 31, 2022

Structural characteristics and potential antidepressant mechanism of a water-insoluble β-1,3-glucan from an edible fungus Wolfiporia cocos.Jan 14, 2025

The positive effects of Poria cocos extract on quality of sleep in insomnia models.Jan 28, 2022

The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism.Nov 13, 2018

Total triterpenes extracted from P. cocos possessed potential antiepileptic properties.Oct 31, 2016

Total triterpenes of Wolfiporia cocos (Schwein.) Ryvarden & Gilb exerts antidepressant-like effects.Dec 31, 2021

Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury.Jul 08, 2013

Water-insoluble polysaccharide extracted from Poria cocos alleviates antibiotic-associated diarrhea.Aug 15, 2023

Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos.Nov 30, 2018

Antioxidant property of water-soluble polysaccharides from Poria cocos Wolf using different extraction methods.Jan 31, 2016

Antitumor activity of the pachymic acid in nasopharyngeal carcinoma cells.Dec 31, 2016

Bioactive compounds and signaling pathways of Wolfiporia extensa in suppressing inflammatory response.Mar 26, 2023

Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.Dec 31, 2016

Characteristics and properties of a polysaccharide isolated from Wolfiporia cocos as potential dietary supplement for IBS.Dec 31, 2022

Co-delivery of Poria cocos extract and doxorubicin as an 'all-in-one' nanocarrier to combat breast cancer multidrug resistance during chemotherapy.Dec 31, 2019

Poria cocos

View the Evidence:
117 Abstracts with Poria cocos Research