Proanthocyanidins

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57 Diseases Researched for Proanthocyanidins
NameACCKFocus
Arteriosclerosis110Locked
Diabetic Retinopathy110Locked
Hypercholesterolemia110Locked
Hypertension110Locked
Lipid Peroxidation110Locked
Menopausal Syndrome110Locked
Obesity47Locked
Kidney Damage36Locked
Oxidative Stress36Locked
Circadian Dysregulation24Locked
Ischemia24Locked
Diabetes Mellitus: Type 223Locked
Ovarian Cancer33Locked
Blood Sugar Problems12Locked
Brain Ischemia12Locked
Cancers: Drug Resistant22Locked
Cervical Cancer12Locked
Colorectal Cancer22Locked
DNA damage12Locked
Ehrlich carcinoma12Locked
Gastrointestinal Inflammation12Locked
Glyphosate Toxicity12Locked
High Fat Diet12Locked
Hyperglycemia12Locked
Hyperinsulinism12Locked
Hyperlipidemia12Locked
Liver Damage12Locked
Norovirus22Locked
Prostate Cancer12Locked
Spinal Cord Injuries12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Ulcerative Colitis12Locked
Acute T cell Leukemias11Locked
Alzheimer's Disease11Locked
Animal Diseases: Canine Distemper Virus11Locked
Bladder Cancer11Locked
Breast Cancer: Bone Metastasis11Locked
Breast Cancer: Triple Negative 11Locked
Carcinoma: Non-Small-Cell Lung11Locked
Coronavirus Disease (Covid-19)11Locked
Coronavirus Infection11Locked
Escherichia coli Infections11Locked
Gastric Cancer11Locked
Head and Neck Cancer11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Infection: Antibiotic Resistant11Locked
Inflammation11Locked
Inflammatory Bowel Diseases11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Mitochondrial Dysfunction 11Locked
Nicotine/Tobacco Toxicity 11Locked
Periodontal Diseases11Locked
Radiation11Locked
Retinal Degeneration: Light-Induced11Locked
Urinary Tract Infections11Locked
40 Pharmacological Actions Researched for Proanthocyanidins
NameACCKFocus
Antioxidants1133Locked
Malondialdehyde Down-regulation314Locked
Antiproliferative 1113Locked
Anticholesteremic Agents110Locked
Antihypertensive Agents110Locked
Apoptotic79Locked
Gastrointestinal Agents59Locked
Anti-Apoptotic58Locked
Cell cycle arrest68Locked
Anti-Inflammatory Agents35Locked
Antiviral Agents55Locked
Neuroprotective Agents35Locked
Nrf2 activation24Locked
Renoprotective24Locked
Anti-metastatic33Locked
NF-kappaB Inhibitor23Locked
Angiogenesis Inhibitors22Locked
Bax/Bcl2 ratio: Increase12Locked
Bcl-2 protein down-regulation12Locked
Chemoprotective Agents12Locked
Heme oxygenase-1 up-regulation12Locked
Hepatoprotective12Locked
Hypolipidemic12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-6 Downregulation12Locked
Nitric Oxide Inhibitor12Locked
Prophylactic Agents12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Alpha-amylase inhibitor11Locked
Alpha-glucosidase inhibitor 11Locked
Angiotensin-Converting Enzyme Inhibitors11Locked
Anti-Angiogenic11Locked
Anti-Bacterial Agents11Locked
Chemosensitizer11Locked
Epidermal growth factor receptor (EGFR) inhibitor11Locked
Gastroprotective11Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor11Locked
Radioprotective11Locked
Vascular Endothelial Growth Factor Inhibitors11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
51 Abstracts with Proanthocyanidins Research

[+]

Association of total flavonoid intake with hypo-HDL-cholesterolemia among Korean adults: effect modification by polyunsaturated fatty acid intake.Jan 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jan 10 ;12(1). Epub 2020 Jan 10. PMID: 31936778
Article Published Date : Jan 09, 2020
Study Type : Human Study
Additional Links
Substances : Flavonoids, Polyunsaturated Fatty Acids (PUFAs), Proanthocyanidins
Diseases : Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents
[+]

Beneficial effects of grape seed extract on malondialdehyde-modified LDL.Mar 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2007 Apr ;53(2):174-82. PMID: 17616006
Article Published Date : Mar 31, 2007
Study Type : Human Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Arteriosclerosis, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure.Aug 31, 2014

Pubmed Data : Menopause. 2014 Sep ;21(9):990-6. PMID: 24518152
Article Published Date : Aug 31, 2014
Study Type : Human Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Hypertension, Menopausal Syndrome
Pharmacological Actions : Antihypertensive Agents, Antioxidants
Additional Keywords : Significant Treatment Outcome
[+]

Oral grape seed proanthocyanidin extract therapy for 1 year improved hard exudates in patients with non-proliferative diabetic retinopathy.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2019 May ;98(21):e15515. PMID: 31124931
Article Published Date : Apr 30, 2019
Study Type : Human Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Diabetic Retinopathy
[+]

Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia.Sep 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Cir Bras. 2020 Sep 4 ;35(8):e202000802. Epub 2020 Sep 4. PMID: 32901679
Article Published Date : Sep 03, 2020
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Ischemia, Kidney Damage, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Proanthocyanidins
[+]

Grape seed proanthocyanidin alleviates intestinal inflammation through gut microbiota-bile acid crosstalk.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2021 ;8:786682. Epub 2022 Jan 28. PMID: 35155513
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Grape seed proanthocyanidin extract treatment maintained nocturnal melatonin levels and altered the oscillations of some metabolites in plasma.Apr 30, 2015

Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID: 25677201
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Melatonin, Proanthocyanidins
Diseases : Circadian Dysregulation
Additional Keywords : Chronobiotic, Circadian Clock Proteins, Plant Extracts
[+]

Grape seed proanthocyanidins exert a neuroprotective effect by regulating microglial M1/M2 polarisation in rats with spinal cord injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2022 ;2022:2579003. Epub 2022 Aug 4. PMID: 35966334
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, NF-kappaB Inhibitor
Additional Keywords : Proanthocyanidins
[+]

Grape seed proanthocyanidins is superior to metformin to promote insulin signaling in rats fed high calorie diet.Sep 11, 2013

Pubmed Data : J Cell Commun Signal. 2013 Sep 12. Epub 2013 Sep 12. PMID: 24026800
Article Published Date : Sep 11, 2013
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Blood Sugar Problems, Diabetes Mellitus: Type 2, Hyperglycemia, Hyperinsulinism
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
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Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jul ;115:108908. Epub 2019 May 17. PMID: 31108378
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : DNA damage, Ehrlich carcinoma, Kidney Damage
Pharmacological Actions : Renoprotective
[+]

Lipophilic grape seed proanthocyanidin exerts anti-cervical cancer effects.Feb 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Feb 19 ;11(2). Epub 2022 Feb 19. PMID: 35204304
Article Published Date : Feb 18, 2022
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest
[+]

Lipophilic grape seed proanthocyanidin inhibited the growth of PC3-derived mouse xenografts by inhibiting tumor cell proliferation and inducing apoptosis.Jan 08, 2019

Pubmed Data : J Agric Food Chem. 2019 Jan 9 ;67(1):229-235. Epub 2018 Dec 28. PMID: 30562012
Article Published Date : Jan 08, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Lotus seed procyanidins prevent oxidative stress by extremely low frequency electromagnetic fields in mice.Aug 01, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:640-8. Epub 2016 Jun 13. PMID: 27470407
Article Published Date : Aug 01, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Oxidant
[+]

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Dec 31, 2018

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Jan 1 ;51(1):31-40. PMID: 30544155
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury.Jul 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2022 Jul 11 ;13(7):594. Epub 2022 Jul 11. PMID: 35821123
Article Published Date : Jul 10, 2022
Study Type : Animal Study
Additional Links
Substances : Proanthocyanidins
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Prophylactic Agents
[+]

Pretreatment of grape seed proanthocyanidin extract exerts neuroprotective effect in murine model of neonatal hypoxic-ischemic brain injury.May 29, 2019

Pubmed Data : Cell Mol Neurobiol. 2019 May 30. Epub 2019 May 30. PMID: 31147852
Article Published Date : May 29, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Brain Ischemia
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2015 Mar ;18(3):280-9. Epub 2015 Jan 8. PMID: 25569813
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Date Seeds, Proanthocyanidins
Diseases : Kidney Damage, Liver Damage
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

Proanthocyanidins from Chinese bayberry leaves reduce obesity and associated metabolic disorders in high-fat diet-induced obesity.Feb 20, 2022

Pubmed Data : Food Funct. 2022 Feb 21 ;13(4):2295-2305. Epub 2022 Feb 21. PMID: 35142317
Article Published Date : Feb 20, 2022
Study Type : Animal Study
Additional Links
Substances : Bayberry, Proanthocyanidins
Diseases : High Fat Diet, Obesity
Additional Keywords : Anti-Obesity Agents
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Proanthocyanidins restore the metabolic diurnal rhythm of subcutaneous white adipose tissue according to time-of-day consumption.May 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 May 27 ;14(11). Epub 2022 May 27. PMID: 35684049
Article Published Date : May 26, 2022
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Circadian Dysregulation, Obesity
Additional Keywords : Anti-Obesity Agents
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The effects of grape seed proanthocyanidins in cafeteria diet-induced obese Fischer 344 rats are influenced by faecal microbiota.Aug 14, 2022

Pubmed Data : Food Funct. 2022 Aug 15 ;13(16):8363-8374. Epub 2022 Aug 15. PMID: 35916585
Article Published Date : Aug 14, 2022
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Obesity
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Anti-Obesity Agents
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The effects of proanthocyanidin on testicular toxicity in rats exposed to a glyphosate-based herbicide.Dec 11, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pol J Vet Sci. 2023 Dec 12 ;26(4):657-666. Epub 2023 Dec 12. PMID: 38088309
Article Published Date : Dec 11, 2023
Study Type : Animal Study
Additional Links
Substances : Proanthocyanidins
Diseases : Glyphosate Toxicity, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants
Problem Substances : Glyphosate
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These findings provide potential mechanisms for grape seed proanthocyanidin intake to improve lipid metabolism.Jun 07, 2019

Pubmed Data : J Nutr. 2019 Jun 8. Epub 2019 Jun 8. PMID: 31175811
Article Published Date : Jun 07, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Hyperlipidemia
Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic
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These findings suggest that grape seed proanthocyanidin extract has a potential protective effect against DSS-induced ulcerative colitis.Jun 08, 2022

Pubmed Data : Curr Drug Metab. 2022 Jun 9. Epub 2022 Jun 9. PMID: 35692132
Article Published Date : Jun 08, 2022
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anthocyanidins inhibit growth and chemosensitize triple-negative breast cancer.Dec 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2021 Dec 13 ;13(24). Epub 2021 Dec 13. PMID: 34944868
Article Published Date : Dec 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Chemosensitizer
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Antitumor effect of proanthocyanidin induced apoptosis in human colorectal cancer (HT-29) cells and its molecular docking studies.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Chem. 2019 Dec ;13(1):21. Epub 2019 Feb 4. PMID: 31384770
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Bayberry leaves proanthocyanidin could be a valuable resource of natural compounds for cancer treatment.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Funct Foods. 2018 Jan ;40:573-581. Epub 2017 Dec 22. PMID: 29576805
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Barberry, Proanthocyanidins
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Cell cycle arrest, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Berberine and oligomeric proanthocyanidins exhibit synergistic efficacy through regulation of PI3K-Akt signaling pathway in colorectal cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2022 ;12:855860. Epub 2022 May 4. PMID: 35600365
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Berberine, Proanthocyanidins
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Natural Substance Synergy
[+]

Bilberry and lingonberry containing anthocyanidins, procyanidin, and resveratrol exert protective effects against blue LED light-induced retinal photoreceptor cell damage.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14:120. Epub 2014 Apr 2. PMID: 24690313
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Bilberry, Lingonberry, Polyphenols, Proanthocyanidins, Resveratrol
Diseases : Retinal Degeneration: Light-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, NF-kappaB Inhibitor
Additional Keywords : Light-Emitting Diodes (LEDs), Phytotherapy, Plant Extracts
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Blueberry proanthocyanidins have potential as preventive and therapeutic options for foodborne viral illnesses.Apr 30, 2017

Pubmed Data : Food Microbiol. 2017 May ;63:263-267. Epub 2016 Nov 30. PMID: 28040178
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Blueberry, Proanthocyanidins
Diseases : Norovirus
Pharmacological Actions : Antiviral Agents
[+]

Cranberry proanthocyanidins may have therapeutic value in periodontal disease.Nov 14, 2011

Pubmed Data : J Agric Food Chem. 2011 Nov 14. Epub 2011 Nov 14. PMID: 22082264
Article Published Date : Nov 14, 2011
Study Type : Review
Additional Links
Substances : Cranberry, Proanthocyanidins
Diseases : Periodontal Diseases
[+]

Cranberry proanthrocyanidins have anti-ovarian cell activity. Sep 12, 2011

Pubmed Data : Int J Oncol. 2011 Sep 12. Epub 2011 Sep 12. PMID: 21922132
Article Published Date : Sep 12, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cranberry, Proanthocyanidins
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-Angiogenic
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Dietary compound proanthocyanidins from Chinese bayberry leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits.Jan 23, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Funct. 2018 Jan 24 ;9(1):525-533. PMID: 29256569
Article Published Date : Jan 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Barberry, Proanthocyanidins
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells, Plant Extracts
[+]

Grape seed proanthocyanidin (GSP) enhances the anti cancer effect of interferon on T24 human bladder carcinoma cellsJan 01, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2012 ;3:107-12. Epub 2012 Mar 1. PMID: 22393334
Article Published Date : Jan 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Grape seed proanthocyanidins prevent H2O2-induced mitochondrial dysfunction and apoptosisJan 13, 2020

Pubmed Data : J Food Biochem. 2020 Jan 14:e13147. Epub 2020 Jan 14. PMID: 31943241
Article Published Date : Jan 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Hydrogen Peroxide Induced Toxicity, Mitochondrial Dysfunction
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

Grape seed proanthocyanidins, honokiol and EGCG appear to be promising bioactive phytochemicals for the management of head and neck cancer.Nov 23, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Nov 24 ;21(12). Epub 2016 Nov 24. PMID: 27886147
Article Published Date : Nov 23, 2016
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Grape Seed Extract, Honokiol, Proanthocyanidins
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Health-promoting properties of proanthocyanidins for intestinal dysfunction.Jan 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jan 2 ;12(1). Epub 2020 Jan 2. PMID: 31906505
Article Published Date : Jan 01, 2020
Study Type : Review
Additional Links
Substances : Proanthocyanidins
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective
[+]

Inhibition of adult T-cell leukemia cell proliferation.Jan 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2022 Jan 31. Epub 2022 Jan 31. PMID: 35100463
Article Published Date : Jan 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Blueberry, Proanthocyanidins
Diseases : Acute T cell Leukemias
Pharmacological Actions : Antiproliferative
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Inhibition of viral RNA synthesis in canine distemper virus infection by proanthocyanidin A2.Nov 30, 2011

Pubmed Data : Antiviral Res. 2011 Dec ;92(3):447-52. Epub 2011 Oct 13. PMID: 22020306
Article Published Date : Nov 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Animal Diseases: Canine Distemper Virus
Pharmacological Actions : Antiviral Agents
Additional Keywords : Proanthocyanidins
[+]

Inhibition of β-amyloid-induced neurotoxicity by planar analogues of procyanidin B3.Jul 22, 2019

Pubmed Data : Bioorg Med Chem Lett. 2019 Jul 23. Epub 2019 Jul 23. PMID: 31371134
Article Published Date : Jul 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Insights into the mechanisms of action of proanthocyanidins and anthocyanins in the treatment of nicotine-induced non-small cell lung cancer.Jul 17, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Jul 18 ;23(14). Epub 2022 Jul 18. PMID: 35887251
Article Published Date : Jul 17, 2022
Study Type : Review
Additional Links
Substances : Anthocyanins, Proanthocyanidins
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Nicotine/Tobacco Toxicity
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic
[+]

Phenolic compounds present in fruit extracts of Malus spp. show antioxidative and pro-apoptotic effects on human gastric cancer cell lines.Aug 31, 2019

Pubmed Data : J Food Biochem. 2019 Sep 1:e13028. Epub 2019 Sep 1. PMID: 31475373
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple, Proanthocyanidins
Diseases : Gastric Cancer
Pharmacological Actions : Antioxidants, Apoptotic
[+]

PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.May 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2019 May 17 ;38(1):204. Epub 2019 May 17. PMID: 31101057
Article Published Date : May 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Proanthocyanidin inhibits the adherence of multi-drug resistant E. coli. Jun 19, 2011

Pubmed Data : Urol Res. 2011 Jun 19. Epub 2011 Jun 19. PMID: 21688109
Article Published Date : Jun 19, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cranberry, Proanthocyanidins
Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Urinary Tract Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Proanthocyanidins are the major anti-diabetic components of cinnamon water extract.Mar 06, 2013

Pubmed Data : Food Chem Toxicol. 2013 Mar 7 ;56C:398-405. Epub 2013 Mar 7. PMID: 23499750
Article Published Date : Mar 06, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon, Proanthocyanidins
Diseases : Diabetes Mellitus: Type 2
[+]

Proanthocyanidins at the gastrointestinal tract: mechanisms involved in their capacity to mitigate obesity-associated metabolic disorders.Aug 08, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Crit Rev Food Sci Nutr. 2022 Aug 9:1-21. Epub 2022 Aug 9. PMID: 35943169
Article Published Date : Aug 08, 2022
Study Type : Review
Additional Links
Substances : Proanthocyanidins
Diseases : Obesity
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor
[+]

Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation.Oct 21, 2019

Pubmed Data : Anticancer Drugs. 2019 Oct 22. Epub 2019 Oct 22. PMID: 31651438
Article Published Date : Oct 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Breast Cancer: Bone Metastasis
Pharmacological Actions : Anti-metastatic
[+]

Proanthocyanidins components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection.Apr 19, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Res Commun. 2022 Apr 20 ;615:56-62. Epub 2022 Apr 20. PMID: 35605406
Article Published Date : Apr 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Blueberry, Proanthocyanidins
Diseases : Coronavirus Infection
Pharmacological Actions : Angiotensin-Converting Enzyme Inhibitors, Antiviral Agents
[+]

Screening of natural extracts with anti-norovirus effects and analysis of this mechanism in grape seed extract.Dec 31, 2022

Pubmed Data : J Microorg Control. 2023 ;28(3):83-92. PMID: 37866900
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Norovirus
Pharmacological Actions : Antiviral Agents
[+]

Synergistic anti-inflammatory effects of lipophilic grape seed proanthocyanidin and camellia oil combination in LPS-stimulated RAW264.7 cells.Jan 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Jan 31 ;11(2). Epub 2022 Jan 31. PMID: 35204172
Article Published Date : Jan 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2.Aug 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Elife. 2023 Aug 29 ;12. Epub 2023 Aug 29. PMID: 37642993
Article Published Date : Aug 28, 2023
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins, Punicalagin
Diseases : Coronavirus Disease (Covid-19)
Pharmacological Actions : Antioxidants, Antiviral Agents
[+]

These results indicate that grape seed proanthocyanidins are expected to be a safe and effective radioprotective drug.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2021 ;8:836528. Epub 2022 Jan 24. PMID: 35141259
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Radiation
Pharmacological Actions : Antioxidants, Radioprotective

Copyright: radiantskies / 123RF Stock Photo

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