Progesterone

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33 Diseases Researched for Progesterone
NameACCKFocus
Amyotrophic Lateral Sclerosis415Locked
Endometriosis211Locked
Preterm Birth: Prevention 211Locked
Human Growth Hormone: Enhancement110Locked
Inappropriate Growth Hormone Secretion Syndrome110Locked
Inappropriate TSH Secretion Syndrome110Locked
Low Human Growth Hormone110Locked
Postmenopausal Disorders110Locked
TSH: Elevated110Locked
Breast Cancer34Locked
Demyelinating Diseases23Locked
Motor Neuron Disease23Locked
Spinal Cord Injuries23Locked
Aging12Locked
Complex Regional Pain Syndrome: Type II12Locked
Convulsions12Locked
Generalized Anxiety Disorder12Locked
Seizures12Locked
Arrhythmias: Cardiac11Locked
Bisphenol Toxicity11Locked
Breast Cancer: Drug Resistant11Locked
Cancers: Drug Resistant11Locked
Dysmenorrhea11Locked
Fibroid Tumor11Locked
Fibroids: Uterine11Locked
Hormone Insufficency11Locked
Infertility: Female11Locked
Leiomyoma11Locked
Motor Neuron Disease: Amyotrophic Lateral Sclerosis11Locked
Osteoporosis11Locked
Ovarian Cancer11Locked
Progesterone: Low11Locked
Prostate Cancer11Locked
15 Pharmacological Actions Researched for Progesterone
NameACCKFocus
Neuroprotective Agents415Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor211Locked
Interleukin-10 downregulation110Locked
Secretagogue110Locked
Enzyme Inhibitors24Locked
Anesthetics12Locked
Anticonvulsants12Locked
Anxiolytic12Locked
Vasopressin Inhibitor12Locked
5-alpha reductase inhibitor11Locked
Anti-Proliferative11Locked
Apoptotic11Locked
Breast cancer resistance protein (BCRP) down-regulation11Locked
Cardioprotective11Locked
Interleukin-6 Downregulation11Locked

View the Evidence:
27 Abstracts with Progesterone Research

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Low levels of progesterone in the follicular phase could be responsible for the progression of endometriosis and related pain. Mar 01, 2010

Pubmed Data : J Mol Med. 2010 Mar;88(3):267-78. Epub 2009 Nov 8. PMID: 19898767
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Substances : Progesterone
Diseases : Endometriosis
Pharmacological Actions : Interleukin-10 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Progesterone is associated with a reduction in the risk of preterm birth and low infant birthweight. Jan 25, 2006

Pubmed Data : Cochrane Database Syst Rev. 2006 Jan 25;(1):CD004947. PMID: 16437505
Article Published Date : Jan 25, 2006
Study Type : Human Study
Additional Links
Substances : Progesterone
Diseases : Preterm Birth: Prevention
[+]

Progesterone levels correlate positively with survival and prognosis in ALS patients.Jan 01, 2011

Pubmed Data : Acta Neurol Scand. 2011 Jan;123(1):60-7. PMID: 20545634
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Progesterone
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women.Feb 02, 2011

Pubmed Data : J Clin Endocrinol Metab. 2011 Feb 2. Epub 2011 Feb 2. PMID: 21289261
Article Published Date : Feb 02, 2011
Study Type : Human Study
Additional Links
Substances : Progesterone
Diseases : Human Growth Hormone: Enhancement, Inappropriate Growth Hormone Secretion Syndrome, Inappropriate TSH Secretion Syndrome, Low Human Growth Hormone, Postmenopausal Disorders, TSH: Elevated
Pharmacological Actions : Secretagogue
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Progesterone demonstrates neuroprotective and promyelinating effects in lesions of the peripheral and central nervous system.Jan 01, 2006

Pubmed Data : J Mol Neurosci. 2006;28(1):3-15. PMID: 16632872
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Demyelinating Diseases, Spinal Cord Injuries
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Progesterone has anticonvulsant activity in mice. Jul 01, 2004

Pubmed Data : J Pharmacol Exp Ther. 2004 Jul;310(1):230-9. Epub 2004 Feb 24. PMID: 14982969
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Convulsions, Seizures
Pharmacological Actions : Anticonvulsants, Enzyme Inhibitors
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Progesterone has neuroprotective properties in a mouse model of spinal cord motor neuron degeneration disease.Dec 01, 2002

Pubmed Data : Neurobiol Dis. 2002 Dec;11(3):457-68. PMID: 12586554
Article Published Date : Dec 01, 2002
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
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Progesterone is able to decrease anxiety behavior in younger and older mice. Jun 01, 2006

Pubmed Data : Psychopharmacology (Berl). 2006 Jun;186(3):312-22. Epub 2006 Mar 15. PMID: 16538472
Article Published Date : Jun 01, 2006
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Aging, Generalized Anxiety Disorder
Pharmacological Actions : Anxiolytic
[+]

Progesterone strongly inhibits breast tumor formation and growth in mice.Mar 01, 1999

Pubmed Data : J Agric Food Chem. 1999 Mar;47(3):840-4. PMID: 11555606
Article Published Date : Mar 01, 1999
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Breast Cancer
Additional Keywords : ER- and PR-Negative Breast Cancer
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Progesterone treatment of adult male rats suppresses arginine vasopressin expression in the bed nucleus of the stria terminalis and the centromedial amygdala.Mar 01, 2006

Pubmed Data : J Neuroendocrinol. 2006 Mar;18(3):187-94. PMID: 16454802
Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Substances : Progesterone
Pharmacological Actions : Vasopressin Inhibitor
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Progestoterone has anesthetic effects. Feb 01, 2005

Pubmed Data : Brain Res. 2005 Feb 1;1033(1):96-101. PMID: 15680344
Article Published Date : Feb 01, 2005
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Complex Regional Pain Syndrome: Type II
Pharmacological Actions : Anesthetics, Enzyme Inhibitors
[+]

Steroid hormones may have neuroprotective properties in ALS. Jun 01, 2001

Pubmed Data : Cell Mol Neurobiol. 2001 Jun;21(3):237-54. PMID: 11569536
Article Published Date : Jun 01, 2001
Study Type : Animal Study
Additional Links
Substances : Estradiol (E(2)), Progesterone, Testosterone
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Pharmacological Actions : Neuroprotective Agents
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"Photo-induced electron emission from 17beta-estradiol and progesterone and possible biological consequences."Jul 24, 2008

Pubmed Data : J Photochem Photobiol B. 2008 Jul 24 ;92(1):38-41. Epub 2008 Apr 15. PMID: 18499468
Article Published Date : Jul 24, 2008
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2)), Progesterone
Problem Substances : 17beta-estradiol
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"Progesterone Receptor Down-Regulates BCRP Expression via Binding to the Progesterone Response Element in Breast Cancer."Feb 20, 2012

Pubmed Data : Cancer Sci. 2012 Feb 20. Epub 2012 Feb 20. PMID: 22348324
Article Published Date : Feb 20, 2012
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Breast Cancer: Drug Resistant, Cancers: Drug Resistant
Pharmacological Actions : Breast cancer resistance protein (BCRP) down-regulation
[+]

Electrons emitted by testosterone are capable of regenerating progesterone. Dec 01, 2011

Pubmed Data : Gynecol Endocrinol. 2011 Dec ;27(12):1077-83. Epub 2011 Apr 11. PMID: 21480767
Article Published Date : Dec 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Progesterone, Testosterone
Diseases : Hormone Insufficency
Additional Keywords : Hormone Regeneration
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Progesterone demonstrates antiproliferative and pro-apoptoic activity against breast cancer cells.Nov 01, 1998

Pubmed Data : Ann Clin Lab Sci. 1998 Nov-Dec;28(6):360-9. PMID: 9846203
Article Published Date : Nov 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Breast Cancer
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Progesterone demonstrates antiproliferative and pro-apoptoic activity against human ovarian cancer cell lines.Feb 01, 2010

Pubmed Data : Diabetes Care. 2010 Feb;33(2):246-51. Epub 2009 Nov 23. PMID: 11500921
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-Proliferative, Apoptotic
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Progesterone enhances cell death in human breast cancer cells.May 01, 2005

Pubmed Data : Lab Invest. 2005 May;85(5):624-32. PMID: 15778733
Article Published Date : May 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Breast Cancer
[+]

Progesterone has neuroprotective properties in traumatic central nervous system and motor neuron degeneration.Jul 01, 2009

Pubmed Data : Front Neuroendocrinol. 2009 Jul;30(2):173-87. Epub 2009 Mar 24. PMID: 19318112
Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Substances : Progesterone
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Motor Neuron Disease: Amyotrophic Lateral Sclerosis, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Progesterone inhibits cytokine-induced interleukein-6 production associated with endometriosis. Jan 01, 2010

Pubmed Data : J Med Case Reports. 2010;4:76. Epub 2010 Mar 2. PMID: 8943541
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Endometriosis
Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Progesterone inhibits IGF-1 expression in human uterine leiomyoma (fibroid) cells. Apr 01, 2004

Pubmed Data : Hum Reprod. 2004 Apr;19(4):815-21. Epub 2004 Jan 29. PMID: 15033949
Article Published Date : Apr 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma
[+]

Progesterone inhibits prostate cancer cells via inhibition of 5-alpha reductase, reducing the conversion of testosterone into dihydrotestosterone.Jul 01, 1989

Pubmed Data : J Pharm Pharmacol. 1989 Jul;41(7):488-9. PMID: 2570857
Article Published Date : Jul 01, 1989
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Prostate Cancer
Pharmacological Actions : 5-alpha reductase inhibitor
[+]

Progesterone may have a therapeutic role in preventing preterm birth. Jan 01, 2004

Pubmed Data : Drugs. 2004;64(21):2463-74. PMID: 15482003
Article Published Date : Jan 01, 2004
Study Type : Commentary
Additional Links
Substances : Progesterone
Diseases : Preterm Birth: Prevention
[+]

Progesterone may offer a therapeutic option for neuroprotection and myelin repair. Oct 01, 2007

Pubmed Data : Pharmacol Ther. 2007 Oct;116(1):77-106. Epub 2007 Jun 18. PMID: 17659348
Article Published Date : Oct 01, 2007
Study Type : Review
Additional Links
Substances : Progesterone
Diseases : Demyelinating Diseases
Additional Keywords : Myelination, Remyelination
[+]

Progesterone may reverse osteoporosis.Aug 01, 1991

Pubmed Data : Med Hypotheses. 1991 Aug;35(4):316-8. PMID: 1943883
Article Published Date : Aug 01, 1991
Study Type : Commentary
Additional Links
Substances : Progesterone
Diseases : Osteoporosis
Additional Keywords : Disease Reversal
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Progesterone protects against bisphenol A-induced arrhythmias in female rat cardiac myocytes.Mar 31, 2017

Pubmed Data : Endocrinology. 2017 Apr 1 ;158(4):778-790. PMID: 28324061
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Arrhythmias: Cardiac, Bisphenol Toxicity
Pharmacological Actions : Cardioprotective
Problem Substances : Bisphenol A
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These data suggest that cinnamaldehyde selectively induced progesterone production and inhibited production of testosterone and dehydroepiandrosterone in human adrenal cells, which may confirm its traditional use for menstrual pain and infertility. Jun 05, 2010

Pubmed Data : Life Sci. 2010 Jun 5;86(23-24):894-8. Epub 2010 Apr 25. PMID: 20423713
Article Published Date : Jun 05, 2010
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde, DHEA (Dehydroepiandrosterone), Progesterone
Diseases : Dysmenorrhea, Infertility: Female, Progesterone: Low
Additional Keywords : Science Confirms Tradition

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