Psilocybin

Name	AC	CK
Depression	97	565
Anxiety	23	154
Cancers: All	8	74
Mood Disorders	7	52
Depression	3	50
Psychiatric Disorders	8	46
Post-Traumatic Stress Disorders (PTSD)	7	45
Obsessive-Compulsive Disorder	10	43
Suicidal Ideation	3	41
Anxiety: End of Life	5	33
Alcohol Addiction	5	23
Anxiety Disorders	4	22
Cancers: Psychological Stress	4	22
Lyme Disease	2	20
Chronic Pain	3	13
Anorexia	3	12
Dysmorphophobia	2	11
Parkinson's Disease	2	11
Smoking Cessation	2	11
Alcohol Toxicity	1	10
Binge Eating	1	10
Cluster Headache	1	10
Drug Abuse	1	10
Phantom Limb	1	10
Psychological Distress	1	10
Suicidal Behavior	1	10
Inflammation	5	7
Aging	3	4
Cognitive Decline/Dysfunction	2	4
Lipopolysaccharide-Induced Toxicity	2	4
Obesity	2	4
Alzheimer's Disease	3	3
Anosmia	1	3
Lupus-Like Syndrome	1	3
Neuropathic Pain	2	3
Neurosis: Obsessive-Compulsive	1	3
Brain Inflammation	1	2
Diabetes Mellitus: Type 2	1	2
Fragile X Syndrome	1	2
Insulin Resistance	1	2
Liver Damage	1	2
Neurodegenerative Diseases	2	2
Psychiatric Disorder: Conditioned Fear	1	2
Sarcopenia	1	2
Substance Abuse	2	2
Tobacco Addiction/Withdrawal	2	2
Traumatic Brain Injury	1	2
Aging Skin	1	1
Borderline Personality Disorder	1	1
Brain Injury: Traumatic	1	1
Depressive Disorder	1	1
Drug Addiction	1	1
Drug Dependence	1	1
Eating Disorders	1	1
Neurological Conditions	1	1
Oxidative Stress	1	1
Substance Use Disorders	1	1

Name	AC	CK
Antidepressive Agents	99	614
Anti-Anxiety Agents	31	190
Neuroprotective Agents	14	62
Anti-Inflammatory Agents	10	32
Analgesics	7	29
Chemotherapeutic	1	21
Anxiolytic	1	20
Neuromodulatory	1	20
Interleukin-6 Downregulation	5	16
Interleukin-1 beta downregulation	4	14
Immunomodulatory	2	11
Neuroplasticity enhancement	7	9
Neurogenesis	3	5
Cyclooxygenase 2 Inhibitors	3	4
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	4
Brain-derived neurotrophic factor modulator	2	2
Hepatoprotective	1	2
Hypoglycemic Agents	1	2
Insulin Sensitizers	1	2
Prophylactic Agents	1	2
Anti-Apoptotic	1	1
Antioxidants	1	1
Monoamine Oxidase Inhibitors	1	1
Telomere Protective	1	1

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Psychoactive Drugs. 2019 Feb 26:1-12. Epub 2019 Feb 26. PMID: 30905276

Article Published Date : Feb 25, 2019

Study Type : Human Study

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Substances : Psilocybin

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A single administration of psilocybin with psychological support was associated with rapid, large-magnitude, and durable reductions in suicidal ideation and depressive symptoms.May 12, 2026

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Pubmed Data : J Clin Psychiatry. 2026 May 13 ;87(2). Epub 2026 May 13. PMID: 42138588

Article Published Date : May 12, 2026

Study Type : Human Study

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Substances : Psilocybin

Diseases : Depression, Suicidal Ideation

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Significant Treatment Outcome

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A single dose psilocybin produced rapid and enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress.Nov 30, 2016

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Pubmed Data : J Psychopharmacol. 2016 Dec ;30(12):1165-1180. PMID: 27909164

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Pubmed Data : JAMA Psychiatry. 2026 May 1 ;83(5):448-460. PMID: 41848690

Article Published Date : Apr 30, 2026

Study Type : Human Study

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Substances : Psilocybin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

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Additional Keywords : Risk Reduction

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Long-term efficacy of psilocybin with adjunct psychotherapy in treatment-resistant major depression.May 26, 2026

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Pubmed Data : Psychother Psychosom. 2026 May 27:1-28. Epub 2026 May 27. PMID: 42201843

Article Published Date : May 26, 2026

Study Type : Human Study

Additional Links

Substances : Psilocybin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

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Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults.Oct 05, 2021

Pubmed Data : Sci Rep. 2026 Feb 25 ;16(1). Epub 2026 Feb 25. PMID: 41741501

Article Published Date : Feb 24, 2026

Study Type : Human Study

Additional Links

Substances : Psilocybin

Diseases : Lyme Disease

Pharmacological Actions : Analgesics

Additional Keywords : Significant Treatment Outcome

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Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention.May 22, 2020

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Pubmed Data : Biol Psychiatry. 2020 Jan 13. Epub 2020 Jan 13. PMID: 32111343

Article Published Date : Jan 12, 2020

Study Type : Human Study

Additional Links

Substances : Psilocybin

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Psilocybin may provide an alternative model for the treatment of anxiety and despair that often accompany advanced-stage cancers.Dec 31, 2010

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Pubmed Data : Arch Gen Psychiatry. 2011 Jan ;68(1):71-8. Epub 2010 Sep 6. PMID: 20819978

Article Published Date : Dec 31, 2010

Study Type : Human Study

Additional Links

Substances : Psilocybin

Diseases : Anxiety Disorders, Cancers: Psychological Stress

Pharmacological Actions : Anti-Anxiety Agents

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Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls.Jun 29, 2022

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Pubmed Data : Psychopharmacology (Berl). 2023 Aug 22. Epub 2023 Aug 22. PMID: 37606733

Article Published Date : Aug 21, 2023

Study Type : Human Study

Additional Links

Substances : Psilocybin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

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Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder.Nov 07, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:841648. Epub 2022 Mar 9. PMID: 35355714

Article Published Date : Dec 31, 2021

Study Type : Human Study

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Substances : Psilocybin

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Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations.Jul 31, 2015

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Pubmed Data : J Psychoactive Drugs. 2023 Aug 31:1-8. Epub 2023 Aug 31. PMID: 37650700

Article Published Date : Aug 30, 2023

Study Type : Human: Case Report

Additional Links

Substances : Lysergic Acid Diethylamide (LSD), Psilocybin

Diseases : Anosmia

Pharmacological Actions : Anti-Inflammatory Agents

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Acute psilocybin enhances cognitive flexibility in rats.May 31, 2023

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Pubmed Data : Exp Brain Res. 2013 Aug ;228(4):481-91. Epub 2013 Jun 2. PMID: 23727882

Article Published Date : Jul 31, 2013

Study Type : Animal Study

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Substances : Psilocybin

Diseases : Post-Traumatic Stress Disorders (PTSD)

Pharmacological Actions : Neurogenesis

Additional Keywords : Extinction Of Fear Conditioning

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Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity Mar 29, 2023

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Pubmed Data : Psychopharmacology (Berl). 2023 Jan ;240(1):137-147. Epub 2022 Dec 5. PMID: 36469097

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Psilocybin

Diseases : Cognitive Decline/Dysfunction, Fragile X Syndrome

Pharmacological Actions : Neuroprotective Agents

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Psilocybin restores behavior and 5-HT2A signaling while reducing microglial density after chronic traumatic brain injury in rats.Jun 11, 2026

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Pubmed Data : J Music Ther. 2020 Mar 30. Epub 2020 Mar 30. PMID: 32227084

Article Published Date : Mar 29, 2020

Study Type : Review

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Substances : Ayahuasca, Lysergic Acid Diethylamide (LSD), Psilocybin, Psychedelics:All

Therapeutic Actions : Music

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Psilocybin alleviates high-glucose and high-lipid-induced skin aging in BJ5Ta fibroblasts.Dec 31, 2024

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Pubmed Data : Biochem Cell Biol. 2025 Jan 1 ;103:1-15. PMID: 41105970

Article Published Date : Dec 31, 2024

Study Type : In Vitro Study

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Substances : Psilocybin

Diseases : Aging Skin, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

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Psilocybin and MDMA for the treatment of trauma-related psychopathology.Apr 30, 2021

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Pubmed Data : Discov Ment Health. 2026 Mar 7 ;6(1). Epub 2026 Mar 7. PMID: 41793582

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Pubmed Data : J Inflamm Res. 2021 ;14:3729-3738. Epub 2021 Aug 5. PMID: 34385833

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Psilocybin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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The therapeutic potential of microdosing psychedelics in depression Dec 31, 2019

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View the Evidence: 194 Abstracts with Psilocybin Research

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Breaking the chains of depression: A systematic review and meta-analysis of psilocybin therapy.Mar 14, 2026

Effect of psilocybin therapy on suicidal ideation, attempts.Dec 31, 2024

Psilocybin may reduce depressive symptoms in cancer patients.Jan 01, 2026

A meta-analysis of placebo-controlled trials of psychedelic-assisted therapy.Jun 11, 2020

Classic serotonergic psychedelics for mood and depressive symptoms.Jan 31, 2021

Dose effect of psilocybin on primary and secondary depression.Sep 16, 2021

Psilocybin as a new approach to treat depression and anxiety in the context of life-threatening diseases.Sep 04, 2020

Psilocybin as a Treatment for Psychiatric Illness: A Meta-Analysis.Oct 31, 2022

Psilocybin may rapidly reduce depressive and anxiety symptoms in cancer patients.Apr 24, 2025

Psilocybin-assisted therapy for major depressive disorder.Jul 31, 2026

Systematic review: psychedelics appear to be effective in significantly reducing symptoms of depression and anxiety and are well-tolerated.Jul 29, 2019

The effects of tryptamine psychedelics in the brain: a meta-analysis of functional and review of molecular imaging studies.Dec 31, 2020

The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis.Jan 01, 2020

1 dose of psilocybin with manualized CBT significantly increased long-term abstinence compared with nicotine patch treatment with CBT.Mar 01, 2026

A single administration of psilocybin may be associated with sub-acute enhancement of creative thinking, empathy, and subjective well-being.Feb 25, 2019

A single administration of psilocybin with psychological support was associated with rapid, large-magnitude, and durable reductions in suicidal ideation and depressive symptoms.May 12, 2026

A single dose psilocybin produced rapid and enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress.Nov 30, 2016

A single psilocybin dose is associated with long-term increased mindfulness.Mar 03, 2020

Administration of up to eight doses of psilocybin in a clinical research setting appears to be safe and potentially effective for patients with OCD.Mar 12, 2026

An open-label pilot study of psilocybin-assisted therapy for binge eating disorder.Jan 02, 2026

Decreases in state and trait anxiety post-psilocybin: A naturalistic, observational study among retreat attendees.Dec 31, 2021

Effects of psilocybin therapy on personality structure.Oct 31, 2018

Efficacy and safety of psilocybin in treatment-resistant major depression.Apr 30, 2026

Exploring the use of psilocybin therapy for existential distress.Jul 15, 2021

High dose psilocybin is associated with positive subjective effects in healthy volunteers.May 31, 2018

Investigational psilocybin treatment for post-traumatic stress disorder.Nov 30, 2025

Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals.Jun 29, 2021

Lifetime psilocybin use was associated with lowered odds of lifetime suicidal thinking, planning, and attempts.Dec 18, 2022

Lifetime use of MDMA/ecstasy and psilocybin is associated with reduced odds of major depressive episodes.Dec 31, 2021

Long-term efficacy of psilocybin with adjunct psychotherapy in treatment-resistant major depression.May 26, 2026

Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults.Oct 05, 2021

Microdosing psilocybin for chronic pain: a case series.Sep 04, 2022

Microdosing psychedelics: personality, mental health, and creativity differences in microdosers.Jan 31, 2019

Natural speech algorithm applied to baseline interview data can predict which patients will respond to psilocybin for treatment-resistant depression.Dec 31, 2017

Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing.Dec 31, 2022

Pilot study of psilocybin in patients with post-treatment lyme disease.Feb 24, 2026

Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention.May 22, 2020

Psilocybin and LSD led to beneficial responses in cluster headaches.Jun 26, 2006

Psilocybin could prove to be revolutionary in treating depression and become an alternative medication to SSRIs.Feb 28, 2024

Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication.Aug 31, 2023

Psilocybin has distinct effects on social cognition by enhancing emotional empathy.Aug 31, 2017

Psilocybin in alcohol use disorder and comorbid depressive symptoms.Jul 23, 2025

Psilocybin induces acute and persisting alterations in immune status in healthy volunteers.Oct 31, 2023

Psilocybin induces time-dependent changes in global functional connectivity.Jan 12, 2020

Psilocybin may provide an alternative model for the treatment of anxiety and despair that often accompany advanced-stage cancers.Dec 31, 2010

Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls.Jun 29, 2022

Psilocybin modulated effective connectivity within the visual-limbic-prefrontal network during threat processing.Dec 31, 2015

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer.Nov 30, 2016

Psilocybin represents a promising paradigm for unresponsive depression.Nov 07, 2017

Psilocybin therapy for females with anorexia nervosa: a phase 1, open-label feasibility study.Jul 31, 2023

Psilocybin therapy for mood dysfunction in Parkinson's disease.Jun 30, 2025

Psilocybin therapy for treatment resistant depression.Aug 21, 2023

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder.Nov 07, 2021

Psilocybin treatment led to significant decreases in alcohol craving and increased the abstinence from alcohol. Feb 28, 2015

Psilocybin treatment was associated with a clinically significant sustained reduction in depressive symptoms and functional disability.Sep 04, 2023

Psilocybin with psychological support is a treatment approach that potentially revives emotional responsiveness in depression.Dec 26, 2017

Psilocybin with psychological support was associated with improvements in anxiety, quality of life, functioning, and PTSD symptoms.Jun 03, 2026

Psilocybin with psychotherapeutic support for treatment-resistant depression.Dec 31, 2024

Psilocybin-assisted group therapy and attachment: observed reduction in attachment anxiety.Apr 08, 2021

Psilocybin-assisted group therapy in patients with cancer diagnosed with a major depressive disorder.Mar 31, 2024

Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects.Apr 05, 2019

Psilocybin-assisted psychotherapy appears safe and may offer durable relief from depression and anxiety in individuals with a life-threatening illness.Dec 31, 2024

Psilocybin-assisted psychotherapy for treatment resistant depression.Mar 07, 2024

Psilocybin-assisted therapy for major depressive disorder.Mar 19, 2023

Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience.Jul 07, 2021

Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report.Dec 31, 2021

Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report.Dec 31, 2021

Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations.Jul 31, 2015

Psilocybin-occasioned mystical-type experience in combination with meditation and spiritual practices produces enduring positive changes.Aug 31, 2017

Psychedelic microdosing benefits and challenges: an empirical codebook.Jul 09, 2019

Relief from intractable phantom pain by combining psilocybin and mirror visual-feedback Mar 31, 2018

Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder.Oct 31, 2006

Psilocybin

View the Evidence:
194 Abstracts with Psilocybin Research