Red Clover

Name	AC	CK
Menopausal Syndrome	11	78
Hot Flash	4	60
Postmenopausal Disorders	3	50
Perimenopausal Syndrome	2	40
Osteoporosis	2	20
Hyperglycemia	1	10
Inflammation	5	8
Breast Cancer	5	6
Diabetes Mellitus: Type 2	3	5
Hyperpigmentation	1	5
Lipopolysaccharide-Induced Toxicity	3	4
Breast Cancer: Triple Negative	2	3
Metabolic Syndrome X	2	3
Neurodegenerative Diseases	2	3
Wound Healing	2	3
Cancers: All	1	2
Diabetic Complications	1	2
Dyslipidemias	1	2
Infertility: Male	1	2
Obesity	1	2
Parkinson's Disease	1	2
Prostate Cancer	2	2
Sunburn	1	2
Acne	1	1
Aging Skin	1	1
Alopecia	1	1
Ammonia: Elevated	1	1
Atherosclerosis	1	1
Brain Cancer	1	1
Cancer Metastasis	1	1
Cardiovascular Diseases	1	1
Eczema	1	1
Glioblastoma	1	1
Glioblastoma Multiforme	1	1
Hair Loss	1	1
Hypoglycemia	1	1
Osteoarthritis	1	1
Oxidative Stress	1	1
Postmenopausal Complications	1	1
Prostatic Hyperplasia: Benign	1	1
Psoriasis	1	1
Rashes	1	1

Name	AC	CK
Hypolipidemic	4	44
Osteoprotective	3	21
Hypoglycemic Agents	3	12
Anticholesteremic Agents	1	10
Antioxidants	6	9
Anti-Inflammatory Agents	6	8
Antiproliferative	5	6
Apoptotic	5	6
Cyclooxygenase 2 Inhibitors	4	5
Neuroprotective Agents	3	5
Antimicrobial	2	3
Chemosensitizer	2	3
Interleukin-1 beta downregulation	2	3
Interleukin-6 Downregulation	2	3
Tumor Necrosis Factor (TNF) Alpha Inhibitor	2	3
Alpha-glucosidase inhibitor	1	2
Angiogenesis Inhibitors	1	2
Anti-Angiogenic	1	2
Anti-metastatic	2	2
Autophagy Up-regulation	2	2
Chemopreventive	1	2
Insulin Sensitizers	1	2
Prophylactic Agents	1	2
Anti-Apoptotic	1	1
Aromatase Inhibitors	1	1
Chondroprotective	1	1
Interleukin-10 upregulation	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
NF-kappaB Inhibitor	1	1
Nrf2 activation	1	1
Pancreato Protective Agents	1	1
Postaglandin PGE2 downregulation	1	1
Vasoprotective	1	1

[+]

Effects of red clover isoflavones on the lipid profile of perimenopausal and postmenopausal women.Jan 31, 2020

Click here to read the entire abstract

Pubmed Data : Maturitas. 2020 Feb ;132:7-16. Epub 2019 Nov 10. PMID: 31883666

Article Published Date : Jan 31, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Red Clover

Diseases : Perimenopausal Syndrome, Postmenopausal Disorders

Pharmacological Actions : Hypolipidemic

[+]

Red clover may have a beneficial effect on the lipid profile of perimenopausal and postmenopausal women.Jan 09, 2018

Click here to read the entire abstract

Pubmed Data : Climacteric. 2018 10 ;21(5):446-453. PMID: 30269660

Article Published Date : Jan 09, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Postmenopausal Disorders

Pharmacological Actions : Hypolipidemic

Additional Keywords : Phytotherapy

[+]

The effect of red clover extract on menopausal symptoms showed a statistically moderate relationship with the reduction in the daily frequency of hot flushes.Apr 10, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2021 Apr 11 ;13(4). Epub 2021 Apr 11. PMID: 33920485

Article Published Date : Apr 10, 2021

Study Type : Meta Analysis, Review

Additional Links

Substances : Red Clover

Diseases : Hot Flash, Menopausal Syndrome

Additional Keywords : Significant Treatment Outcome

[+]

A combination of standardized extracts of black cohosh, dong quai, milk thistle, red clover, American ginseng, chaste-tree berry can be safe and effective for the relief of menopausal symptoms in pre- and postmenopausal women when used for 3 months..Feb 01, 2007

Click here to read the entire abstract

Pubmed Data : Gynecol Endocrinol. 2007 Feb ;23(2):117-22. PMID: 17454163

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Dong Quai, Milk Thistle, Red Clover

Diseases : Hot Flash, Menopausal Syndrome

Additional Keywords : Menopause, Phytotherapy, Plant Extracts

[+]

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women.Aug 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Clin Nutr. 2017 Sep ;106(3):909-920. Epub 2017 Aug 2. PMID: 28768651

Article Published Date : Aug 31, 2017

Study Type : Human Study

Additional Links

Substances : Isoflavones, Probiotics, Red Clover

Diseases : Osteoporosis, Postmenopausal Disorders

Pharmacological Actions : Osteoprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Combined red clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(6):e0176590. Epub 2017 Jun 7. PMID: 28591133

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Isoflavones, Probiotics, Red Clover

Diseases : Menopausal Syndrome

[+]

Effects of isoflavone-rich red clover extract on blood glucose level.Mar 31, 2021

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Pubmed Data : J Food Sci. 2021 Apr ;86(4):1393-1399. Epub 2021 Mar 24. PMID: 33761143

Article Published Date : Mar 31, 2021

Study Type : Human Study

Additional Links

Substances : Formononetin, Isoflavones, Red Clover

Diseases : Hyperglycemia

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Plant Extracts

[+]

Isoflavones attenuate bone loss and have a potentially protective effect on the lumbar spine in womenFeb 01, 2004

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Pubmed Data : Am J Clin Nutr. 2004 Feb;79(2):326-33. PMID: 14749241

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Osteoporosis

[+]

Red clover extract had positive effect on bone health in healthy menopausal women.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:689138. Epub 2015 Jul 21. PMID: 26265926

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Red Clover

Diseases : Menopausal Syndrome

Pharmacological Actions : Osteoprotective

[+]

Red clover isoflavones enriched with formononetin lowers serum LDL cholesterol.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Clin Nutr. 2015 Jan ;69(1):134-42. Epub 2014 Nov 5. PMID: 25369831

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Menopausal Syndrome

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Plant Extracts

[+]

Red clover isoflavones significantly reduce menopausal hot flush symptoms. Jul 25, 2002

Click here to read the entire abstract

Pubmed Data : Maturitas. 2002 Jul 25;42(3):187-93. PMID: 12161042

Article Published Date : Jul 25, 2002

Study Type : Human Study

Additional Links

Substances : Red Clover

Diseases : Hot Flash

[+]

Red Clover significantly decreases menopausal symptoms in postmenopausal women. Nov 01, 2005

Click here to read the entire abstract

Pubmed Data : Gynecol Endocrinol. 2005 Nov;21(5):257-64. PMID: 16373244

Article Published Date : Nov 01, 2005

Study Type : Human Study

Additional Links

Substances : Red Clover

Diseases : Menopausal Syndrome

[+]

Biochanin A from red clover inhibits melanogenesis and may be helpful for hyperpigmentation disorders.Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : Biosci Biotechnol Biochem. 2011 ;75(5):914-8. Epub 2011 May 20. PMID: 21597196

Article Published Date : Jan 01, 2011

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Biochanin A, Genistein, Red Clover

Diseases : Hyperpigmentation

[+]

Irilone from red clover potentiates progesterone signaling.Jan 28, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nat Prod. 2018 09 28 ;81(9):1962-1967. Epub 2018 Sep 10. PMID: 30199256

Article Published Date : Jan 28, 2018

Study Type : Human In Vitro

Additional Links

Substances : Isoflavones, Red Clover

Additional Keywords : Drug Synergy, Plant Extracts

[+]

Biochanin A ameliorates histological changes of renal and cutaneous tissue related to ovariectomy and/or anastrozole treatment.May 15, 2018

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Pubmed Data : Life Sci. 2018 May 15 ;201:9-16. Epub 2018 Mar 19. PMID: 29567078

Article Published Date : May 15, 2018

Study Type : Animal Study

Additional Links

Substances : Biochanin A, Genistein, Red Clover

Diseases : Menopausal Syndrome

Pharmacological Actions : Antioxidants

Additional Keywords : Ovariectomy-Induced Changes

[+]

Combination of red clover and hops extract improved menopause symptoms.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:7941391. Epub 2020 May 23. PMID: 32595737

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Hops, Red Clover

Diseases : Menopausal Syndrome

Pharmacological Actions : Antioxidants, Hypolipidemic

[+]

Ginkgo biloba and red clover in combination was more effective as protective agents compared to each one of them alone.Jul 31, 2016

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Pubmed Data : Food Chem Toxicol. 2016 Aug ;94:112-27. Epub 2016 May 24. PMID: 27234133

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba, Red Clover

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents, Prophylactic Agents

Additional Keywords : Natural Substance Synergy

Problem Substances : Arsenite

[+]

Inhibition of angiogenesis and inflammation by an extract of red clover.Nov 30, 2009

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Pubmed Data : Phytomedicine. 2009 Dec ;16(12):1083-8. Epub 2009 Aug 7. PMID: 19665361

Article Published Date : Nov 30, 2009

Study Type : Animal Study

Additional Links

Substances : Red Clover

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Angiogenic, Chemopreventive

Additional Keywords : Plant Extracts

[+]

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models.Nov 28, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Funct. 2021 Nov 29 ;12(23):11987-12007. Epub 2021 Nov 29. PMID: 34751296

Article Published Date : Nov 28, 2021

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Red clover and pomegranate powder synergically and potently relieve climacterium symptoms, especially obesity and osteoporosis in menopausal females.Mar 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2015 Apr ;7(4):2622-47. Epub 2015 Apr 9. PMID: 25912038

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Pomegranate, Red Clover

Diseases : Menopausal Syndrome, Obesity

Additional Keywords : Anti-Obesity Agents, Natural Substance Synergy

[+]

red clover extract and biochanin A or formononetin significantly ameliorate the lipid profiles of STZ-diabetic mice.May 31, 2012

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2012 Jun ;26(6):860-4. Epub 2011 Nov 14. PMID: 22084061

Article Published Date : May 31, 2012

Study Type : Animal Study

Additional Links

Substances : Biochanin A, Formononetin, Red Clover

Diseases : Diabetes Mellitus: Type 2, Dyslipidemias

Pharmacological Actions : Hypolipidemic

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Red clover extract exerts potential anti-inflammatory effects by suppressing the activation of the NF-κB and MAPK pathways.Oct 14, 2018

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Pubmed Data : Arch Physiol Biochem. 2018 Oct 15:1-8. Epub 2018 Oct 15. PMID: 30320514

Article Published Date : Oct 14, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Red clover has a beneficial role in improving insulin sensitivity.Mar 18, 2020

Click here to read the entire abstract

Pubmed Data : Chem Biodivers. 2020 Mar 18. Epub 2020 Mar 18. PMID: 32187456

Article Published Date : Mar 18, 2020

Study Type : Animal Study

Additional Links

Substances : Red Clover

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Insulin Sensitizers

[+]

Red clover protect against inflammation and immune suppression induced by topical UV radiation.Sep 01, 2001

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Pubmed Data : Photochem Photobiol. 2001 Sep ;74(3):465-70. PMID: 11594062

Article Published Date : Sep 01, 2001

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Inflammation, Sunburn

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Red clover sprout prevents metabolic syndrome.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2020 ;66(1):48-53. PMID: 32115453

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Red Clover

Diseases : Metabolic Syndrome X

Pharmacological Actions : Alpha-glucosidase inhibitor

[+]

The effect of an ointment from Trifolium repens hydroethanolic extract on the acceleration of excisional cutaneous wound healing. Oct 31, 2020

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Pubmed Data : Wounds. 2020 Nov ;32(11):309-318. PMID: 33465043

Article Published Date : Oct 31, 2020

Study Type : Animal Study

Additional Links

Substances : Red Clover

Diseases : Wound Healing

Pharmacological Actions : Antimicrobial

[+]

The key findings indicated the synergistic effects of DOX and T. pratense against TNBC xenografts.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Nutr. 2020 Aug ;8(8):4276-4290. Epub 2020 Jul 6. PMID: 32884708

Article Published Date : Jul 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Trifolium pratense extract increases testosterone and improves sperm characteristics and antioxidant status in diabetic rats.Feb 13, 2022

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Pubmed Data : Biotech Histochem. 2022 Feb 14:1-8. Epub 2022 Feb 14. PMID: 35164615

Article Published Date : Feb 13, 2022

Study Type : Animal Study

Additional Links

Substances : Red Clover

Diseases : Diabetic Complications, Infertility: Male

Pharmacological Actions : Antioxidants

[+]

A review of herbal preparations for the treatment of hair loss.Nov 02, 2019

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Pubmed Data : Arch Dermatol Res. 2019 Nov 3. Epub 2019 Nov 3. PMID: 31680216

Article Published Date : Nov 02, 2019

Study Type : Review

Additional Links

Substances : Ginger, Ginseng, Ginseng (Korean), Pumpkin, Red Clover, Saw Palmetto

Diseases : Alopecia, Hair Loss

[+]

Anthocyanins in red clover are the potential candidates to reduce inflammation and oxidative stress.Apr 14, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Apr 15 ;12(4). Epub 2020 Apr 15. PMID: 32326385

Article Published Date : Apr 14, 2020

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Red Clover

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nrf2 activation

[+]

Biochanin A reduces the abundance of proteolytic bacteria and production of ammonia.Feb 25, 2020

Click here to read the entire abstract

Pubmed Data : Animals (Basel). 2020 Feb 25 ;10(3). Epub 2020 Feb 25. PMID: 32106487

Article Published Date : Feb 25, 2020

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A, Red Clover

Diseases : Ammonia: Elevated

Pharmacological Actions : Antimicrobial

[+]

Clinical studies of red clover dietary supplements in menopause: a literature review.Feb 28, 2006

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Pubmed Data : Menopause. 2006 Mar-Apr;13(2):251-64. PMID: 16645539

Article Published Date : Feb 28, 2006

Study Type : Review

Additional Links

Substances : Red Clover

Diseases : Atherosclerosis, Menopausal Syndrome

Pharmacological Actions : Osteoprotective , Vasoprotective

Additional Keywords : Phytotherapy

[+]

Effects of red clover extracts on breast cancer cell migration and invasion.Dec 31, 2011

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Pubmed Data : Gynecol Endocrinol. 2012 Jan ;28(1):29-33. Epub 2011 May 26. PMID: 21615235

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Breast Cancer, Cancer Metastasis, Postmenopausal Complications

Pharmacological Actions : Anti-metastatic

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Extraction, purification, hypoglycemic and antioxidant activities of red clover polysaccharides.Jan 20, 2020

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Pubmed Data : Int J Biol Macromol. 2020 Jan 21 ;148:750-760. Epub 2020 Jan 21. PMID: 31978472

Article Published Date : Jan 20, 2020

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Hypoglycemia, Oxidative Stress

Pharmacological Actions : Antioxidants, Hypoglycemic Agents

Additional Keywords : Polysaccharides

[+]

Formononetin-induced apoptosis of human prostate cancer cells through ERK1/2 mitogen-activated protein kinase inactivation.Mar 31, 2012

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Pubmed Data : Horm Metab Res. 2012 Apr ;44(4):263-7. Epub 2012 Feb 10. PMID: 22328166

Article Published Date : Mar 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

[+]

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen-isoflavones.May 31, 2023

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Pubmed Data : Phytother Res. 2023 Jun ;37(6):2693-2737. Epub 2023 May 17. PMID: 37195042

Article Published Date : May 31, 2023

Study Type : Review

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Perspectives on the combined effects of Ocimum basilicum and Trifolium pratense extracts in terms of phytochemical profile and pharmacological effects.Jul 06, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Plants (Basel). 2021 Jul 7 ;10(7). Epub 2021 Jul 7. PMID: 34371593

Article Published Date : Jul 06, 2021

Study Type : Review

Additional Links

Substances : Basil, Red Clover

Diseases : Acne, Aging Skin, Eczema, Psoriasis, Rashes, Wound Healing

Pharmacological Actions : Antioxidants

[+]

Red clover as a dietary supplement can be beneficial for some patients with breast cancer who receive conventional chemotherapy.Dec 31, 2018

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Pubmed Data : Nutr Cancer. 2019 ;71(1):128-140. Epub 2018 Dec 29. PMID: 30596276

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Autophagy Up-regulation, Chemosensitizer

Additional Keywords : Dose Response, Synergy with Tamoxifen

[+]

Red clover demonstrates aromatase inhibition activity, which may reduce the risk of estrogen receptor positive breast cancer.Feb 01, 2008

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Pubmed Data : Br J Nutr. 2008 Feb;99(2):303-10. Epub 2007 Aug 29. PMID: 17761019

Article Published Date : Feb 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A, Red Clover

Diseases : Breast Cancer

Pharmacological Actions : Aromatase Inhibitors

[+]

Red clover extract has a chondroprotective effect on inflammation and may be a potential preventative agent for osteoarthritis progression.Dec 31, 2017

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Pubmed Data : Cells Tissues Organs. 2018 ;206(1-2):95-105. Epub 2019 Jan 31. PMID: 30703768

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Postaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Red clover extract may provide a simultaneous treatment for menopausal disorders and the metabolic syndrome.Nov 01, 2008

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Pubmed Data : Menopause. 2008 Nov-Dec;15(6):1120-31. PMID: 18724264

Article Published Date : Nov 01, 2008

Study Type : Commentary

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Menopausal Syndrome, Metabolic Syndrome X

Additional Keywords : Plant Extracts

[+]

Red Clover isoflavones induce programmed cell death in human prostate cells.Dec 01, 2002

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1689-96. PMID: 12496063

Article Published Date : Dec 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic

[+]

Red clover isoflavones inhibit the proliferation and promote programmed cell death of benign prostatic hyperplasia stromal cellsJan 01, 2010

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Pubmed Data : Zhonghua Nan Ke Xue. 2010 Jan;16(1):34-9. PMID: 20180402

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Apoptotic

[+]

Red clover may reduce inflammation associated with cardiovascular disease by ameliorating lipopolysaccharide-induced toxicity. Feb 05, 2010

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Pubmed Data : Menopause. 2010 Feb 5. Epub 2010 Feb 5. PMID: 20142789

Article Published Date : Feb 05, 2010

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Cardiovascular Diseases, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

T. pratense not only has anti-diabetic actions on β cells but also enhances their viability.Jul 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Res Pharm Sci. 2018 Aug ;13(4):324-331. PMID: 30065765

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Apoptotic, Hypoglycemic Agents, Pancreato Protective Agents

[+]

T. pratense showed anti-cancer properties via induction of apoptosis and autophagy cell death.Sep 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell J. 2018 Oct ;20(3):412-421. Epub 2018 May 15. PMID: 29845796

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

[+]

T. pratense sprouts can be considered a potent dietary supplement with anti-cancer and anti-invasion properties.Jan 18, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Jan 19 ;12(1). Epub 2020 Jan 19. PMID: 31963833

Article Published Date : Jan 18, 2020

Study Type : In Vitro Study

Additional Links

Substances : Red Clover

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

The isoflavones genistein and biochanin A found in soy and red clover, respectively, inhibit human glioblastoma cells. Sep 01, 2006

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Pubmed Data : J Neurooncol. 2006 Sep;79(2):135-42. Epub 2006 Apr 6. PMID: 16598420

Article Published Date : Sep 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Genistein, Isoflavones, Red Clover

Diseases : Brain Cancer, Glioblastoma

[+]

This is the first report of the presence of potent cyclooxygenase-2 inhibitors in Trifolium pratense L. extracts.Feb 28, 2019

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Pubmed Data : J Sep Sci. 2019 Mar ;42(6):1133-1143. Epub 2019 Feb 25. PMID: 30620132

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A, Daidzein, Formononetin, Genistein, Isoflavones, Red Clover

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Plant Extracts

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A standardised extract of red clover isoflavones had a statistical and clinically significant benefit for treating hot flushes in menopausal women.Jan 14, 2017

Effects of red clover isoflavones on the lipid profile of perimenopausal and postmenopausal women.Jan 31, 2020

Red clover may have a beneficial effect on the lipid profile of perimenopausal and postmenopausal women.Jan 09, 2018

The effect of red clover extract on menopausal symptoms showed a statistically moderate relationship with the reduction in the daily frequency of hot flushes.Apr 10, 2021

A combination of standardized extracts of black cohosh, dong quai, milk thistle, red clover, American ginseng, chaste-tree berry can be safe and effective for the relief of menopausal symptoms in pre- and postmenopausal women when used for 3 months..Feb 01, 2007

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women.Aug 31, 2017

Combined red clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.Dec 31, 2016

Effects of isoflavone-rich red clover extract on blood glucose level.Mar 31, 2021

Isoflavones attenuate bone loss and have a potentially protective effect on the lumbar spine in womenFeb 01, 2004

Red clover extract had positive effect on bone health in healthy menopausal women.Dec 31, 2014

Red clover isoflavones enriched with formononetin lowers serum LDL cholesterol.Dec 31, 2014

Red clover isoflavones significantly reduce menopausal hot flush symptoms. Jul 25, 2002

Red Clover significantly decreases menopausal symptoms in postmenopausal women. Nov 01, 2005

Biochanin A from red clover inhibits melanogenesis and may be helpful for hyperpigmentation disorders.Jan 01, 2011

Irilone from red clover potentiates progesterone signaling.Jan 28, 2018

Biochanin A ameliorates histological changes of renal and cutaneous tissue related to ovariectomy and/or anastrozole treatment.May 15, 2018

Combination of red clover and hops extract improved menopause symptoms.Dec 31, 2019

Ginkgo biloba and red clover in combination was more effective as protective agents compared to each one of them alone.Jul 31, 2016

Inhibition of angiogenesis and inflammation by an extract of red clover.Nov 30, 2009

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models.Nov 28, 2021

Red clover and pomegranate powder synergically and potently relieve climacterium symptoms, especially obesity and osteoporosis in menopausal females.Mar 31, 2015

red clover extract and biochanin A or formononetin significantly ameliorate the lipid profiles of STZ-diabetic mice.May 31, 2012

Red clover extract exerts potential anti-inflammatory effects by suppressing the activation of the NF-κB and MAPK pathways.Oct 14, 2018

Red clover has a beneficial role in improving insulin sensitivity.Mar 18, 2020

Red clover protect against inflammation and immune suppression induced by topical UV radiation.Sep 01, 2001

Red clover sprout prevents metabolic syndrome.Dec 31, 2019

The effect of an ointment from Trifolium repens hydroethanolic extract on the acceleration of excisional cutaneous wound healing. Oct 31, 2020

The key findings indicated the synergistic effects of DOX and T. pratense against TNBC xenografts.Jul 31, 2020

Trifolium pratense extract increases testosterone and improves sperm characteristics and antioxidant status in diabetic rats.Feb 13, 2022

A review of herbal preparations for the treatment of hair loss.Nov 02, 2019

Anthocyanins in red clover are the potential candidates to reduce inflammation and oxidative stress.Apr 14, 2020

Biochanin A reduces the abundance of proteolytic bacteria and production of ammonia.Feb 25, 2020

Clinical studies of red clover dietary supplements in menopause: a literature review.Feb 28, 2006

Effects of red clover extracts on breast cancer cell migration and invasion.Dec 31, 2011

Extraction, purification, hypoglycemic and antioxidant activities of red clover polysaccharides.Jan 20, 2020

Formononetin-induced apoptosis of human prostate cancer cells through ERK1/2 mitogen-activated protein kinase inactivation.Mar 31, 2012

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen-isoflavones.May 31, 2023

Perspectives on the combined effects of Ocimum basilicum and Trifolium pratense extracts in terms of phytochemical profile and pharmacological effects.Jul 06, 2021

Red clover as a dietary supplement can be beneficial for some patients with breast cancer who receive conventional chemotherapy.Dec 31, 2018

Red clover demonstrates aromatase inhibition activity, which may reduce the risk of estrogen receptor positive breast cancer.Feb 01, 2008

Red clover extract has a chondroprotective effect on inflammation and may be a potential preventative agent for osteoarthritis progression.Dec 31, 2017

Red clover extract may provide a simultaneous treatment for menopausal disorders and the metabolic syndrome.Nov 01, 2008

Red Clover isoflavones induce programmed cell death in human prostate cells.Dec 01, 2002

Red clover isoflavones inhibit the proliferation and promote programmed cell death of benign prostatic hyperplasia stromal cellsJan 01, 2010

Red clover may reduce inflammation associated with cardiovascular disease by ameliorating lipopolysaccharide-induced toxicity. Feb 05, 2010

T. pratense not only has anti-diabetic actions on β cells but also enhances their viability.Jul 31, 2018

T. pratense showed anti-cancer properties via induction of apoptosis and autophagy cell death.Sep 30, 2018

T. pratense sprouts can be considered a potent dietary supplement with anti-cancer and anti-invasion properties.Jan 18, 2020

The isoflavones genistein and biochanin A found in soy and red clover, respectively, inhibit human glioblastoma cells. Sep 01, 2006

This is the first report of the presence of potent cyclooxygenase-2 inhibitors in Trifolium pratense L. extracts.Feb 28, 2019

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