Red Sage

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83 Diseases Researched for Red Sage
NameACCKFocus
C-Reactive Protein110Locked
Cerebral Stroke110Locked
Chronic Fatigue Syndrome110Locked
Coronary Artery Disease110Locked
Hepatitis B 110Locked
Inflammation610Locked
Oligohydramnios110Locked
Osteonecrosis110Locked
Oxidative Stress510Locked
Pancreatitis110Locked
Stroke: Prevention 110Locked
Myocardial Infarction59Locked
Lipopolysaccharide-Induced Toxicity47Locked
Aneurysm: Aortic36Locked
Breast Cancer35Locked
Bone Fractures24Locked
Cerebral Ischemia24Locked
Ischemia24Locked
Lung Injury: Acute24Locked
Sepsis24Locked
Lung Cancer33Locked
Acid Reflux12Locked
Alcoholic Liver Disease12Locked
Alzheimer's Disease12Locked
Anxiety12Locked
Aortic Aneurysm12Locked
Brain Ischemia12Locked
Cardiac Arrhythmias12Locked
Cardiac Mortality 12Locked
Chemotherapy-Induced Toxicity: Adriamycin12Locked
Chemotherapy-Induced Toxicity: Bleomycin12Locked
Chemotherapy-Induced Toxicity: Doxorubicin12Locked
Dementia12Locked
Depression12Locked
Diabetes: Kidney Function 12Locked
Fatty Liver12Locked
Gastric Ulcer12Locked
Herniated Disc12Locked
High Fat Diet12Locked
Hypertension12Locked
Hypertension: Pulmonary12Locked
Hyperthyroidism12Locked
Hypoxia12Locked
Interstitial Lung Diseases12Locked
Intervertebral Disk Displacement12Locked
Lipid Peroxidation12Locked
Liver Cancer22Locked
Liver Damage12Locked
Liver Fibrosis12Locked
Myocardial Fibrosis 12Locked
Myocardial Ischemia12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Organ Transplantation: Liver12Locked
Pulmonary Fibrosis22Locked
Pulmonary Hypertension12Locked
Restenosis12Locked
Right Ventricular Hypertrophy12Locked
Spinal Cord Injuries12Locked
Stroke12Locked
Stroke: Attenuation/Recovery 12Locked
Subarachnoid hemorrhage12Locked
Acute Myeloid Leukemia11Locked
Asthma11Locked
Cancers: Drug Resistant11Locked
Central Nervous System Diseases11Locked
Cervical Cancer11Locked
Colorectal Cancer11Locked
Coronavirus Disease (Covid-19)11Locked
Coronavirus Infection11Locked
Diabetic Nephropathy11Locked
Dopamine Deficiency11Locked
Endometriosis11Locked
Glioma11Locked
HIV Infections11Locked
Leukemia11Locked
Oral Cancer11Locked
Osteosarcoma11Locked
Parkinson's Disease11Locked
Prostate Cancer11Locked
Scleroderma11Locked
Scleroderma: Systemic 11Locked
Squamous cell carcinoma11Locked
Stem Cell Transplant11Locked
47 Pharmacological Actions Researched for Red Sage
NameACCKFocus
Tumor Necrosis Factor (TNF) Alpha Inhibitor1332Locked
Interleukin-6 Downregulation1128Locked
Anti-Inflammatory Agents1119Locked
Antioxidants1119Locked
Interleukin-8 downregulation212Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor611Locked
Antiproliferative 910Locked
Cardioprotective510Locked
Apoptotic89Locked
Interleukin-1 beta downregulation59Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor48Locked
Neuroprotective Agents48Locked
Anti-Apoptotic36Locked
Nrf2 activation35Locked
Renoprotective35Locked
Anti-Fibrotic24Locked
Cyclooxygenase 2 Inhibitors23Locked
Angiogenesis Inducing Agents12Locked
Anti-Anxiety Agents12Locked
Anti-Ulcer Agents12Locked
Anti-metastatic22Locked
Antidepressive Agents12Locked
Antihypertensive Agents12Locked
Calcium Channel Blockers12Locked
Chemoprotective Agents12Locked
Hepatoprotective12Locked
Interleukin-10 downregulation12Locked
NF-kappaB Inhibitor12Locked
Neuritogenic12Locked
Nitric Oxide Inhibitor12Locked
Proton Pump Inhibitor12Locked
Vascular Endothelial Growth Factor A Inhibitor12Locked
Vascular Endothelial Growth Factor Regulator12Locked
Vasodilator Agents12Locked
Anti-Retroviral Agents11Locked
Antiviral Agents11Locked
Brain-derived neurotrophic factor modulator11Locked
Caspase-3 Activation11Locked
Chemosensitizer11Locked
Chemotherapeutic11Locked
Dopaminergic11Locked
Fibrinolytic Agents11Locked
Interleukin-4 downregulation11Locked
Interleukin-5 downregulation11Locked
Multidrug Resistance Gene Modulators11Locked
Telomerase Inhibitor11Locked
interleukin-13 down-regulation11Locked

View the Evidence:
76 Abstracts with Red Sage Research

[+]

Astralagus and Red Sage (Salvia miltiorrhiza) significantly decreased fatigue in Chronic Fatigue Syndrome. Jun 01, 2009

Pubmed Data : Complement Ther Med. 2009 Jun;17(3):141-6. Epub 2009 Jan 23. PMID: 19398067
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Substances : Astragalus, Red Sage
Diseases : Chronic Fatigue Syndrome
Additional Keywords : Controlled Pilot Study, Double-Blind
[+]

Combined therapy of Red sage (S. miltiorrhizae) and Zhu Ling (P. umbellatus) polysaccharide has therapeutic value in the treatment of chronic hepatitis B.Sep 01, 1993

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Sep;13(9):533-5, 516-7. PMID: 8111209
Article Published Date : Sep 01, 1993
Study Type : Human Study
Additional Links
Substances : Red Sage, Zhu Ling Mushroom
Diseases : Hepatitis B
Additional Keywords : Plant Extracts
[+]

Red sage (S. mitiorrhiza) and kudzu (Pueraria lobata) improve vascular function and structure in coronary patients. Apr 01, 2009

Pubmed Data : J Altern Complement Med. 2009 Apr;15(4):415-21. PMID: 19388864
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : Kudzu, Red Sage
Diseases : Coronary Artery Disease
[+]

Red Sage (Salvia miltiorrhiza) decreases blood c-reactive protein and prevents ischemic stroke recurrence. May 15, 2009

Pubmed Data : Phytother Res. 2009 May 15. PMID: 19449344
Article Published Date : May 15, 2009
Study Type : Human Study
Additional Links
Substances : Red Sage
Diseases : C-Reactive Protein, Cerebral Stroke, Stroke: Prevention
[+]

Salvia miltiorrhiza (red sage) has a therapeutic effect in the treatment of oligohydramnios. Feb 01, 2008

Pubmed Data : Ther Clin Risk Manag. 2008 Feb;4(1):287-90. PMID: 18728717
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Substances : Red Sage
Diseases : Oligohydramnios
[+]

Salvia miltiorrhiza mitigates severe acute pancreatitis.Jan 01, 2007

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):28-31. PMID: 17214932
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Substances : Red Sage
Diseases : Pancreatitis
Pharmacological Actions : Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The injection of Red Sage (Danshen) through Chinese medical techniques may have a therapeutic role in the treatment of osteonecrosis. Feb 01, 2009

Pubmed Data : Zhen Ci Yan Jiu. 2009 Feb;34(1):57-60. PMID: 19526810
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Substances : Red Sage
Diseases : Osteonecrosis
[+]

A Chinese herbal formula containing Red Sage, Cordyceps and Peach kernel is superior to methylprednisone against experimental pulmonary fibrosis. May 01, 2007

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):835-9. PMID: 17639988
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

A combination of Red Sage (Salviae Miltiorrhiza), Panax notoginseny and Dyroblanops aromatica may prevent alcoholic fatty liver disease. Dec 01, 2009

Pubmed Data : Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009 Dec;44(6):636-48. PMID: 20077758
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Dryobalanops aromatica, Panax Notoginseng, Red Sage
Diseases : Alcoholic Liver Disease, Fatty Liver
[+]

A compound found within Red Sage, salvianolic acid B, alleviates brain damage and reverses some motor function loss in a rat model of stroke. Jul 01, 2005

Pubmed Data : Curr Eye Res. 2005 Jul;30(7):583-91. PMID: 17882954
Article Published Date : Jul 01, 2005
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Brain Ischemia, Cerebral Ischemia, Stroke, Stroke: Attenuation/Recovery
Pharmacological Actions : Neuritogenic
Additional Keywords : Nerve Regeneration, Regenerative Substances, Stroke: Recovery
[+]

Components of Salvia miltiorrhiza Bunge, could inhibit the development of elastase-induced experimental abdominal aortic aneurysms.Nov 30, 2012

Pubmed Data : J Surg Res. 2012 Dec ;178(2):1029-37. Epub 2012 May 17. PMID: 22640888
Article Published Date : Nov 30, 2012
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Aneurysm: Aortic, Hypertension, Oxidative Stress
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Decrease in the generation of Amyloid-β due to Salvianolic acid B by modulating BACE1 activity.Dec 31, 2016

Pubmed Data : Curr Alzheimer Res. 2017 ;14(11):1229-1237. PMID: 28413985
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Dihydrotanshinone I alleviates spinal cord injury.Feb 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2020 Feb 29 ;26:e920738. Epub 2020 Feb 29. PMID: 32112706
Article Published Date : Feb 28, 2020
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mechanism of salvianolic acid B neuroprotection against ischemia/reperfusion induced cerebral injury.Jan 14, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Res. 2018 01 15 ;1679:125-133. Epub 2017 Nov 24. PMID: 29180227
Article Published Date : Jan 14, 2018
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mechanistic insights into tanshinone IIA in the amelioration of post-thyroidectomy hypoparathyroidism.Dec 31, 2023

Pubmed Data : Crit Rev Immunol. 2024 ;44(6):27-36. PMID: 38848291
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Hyperthyroidism
Pharmacological Actions : Angiogenesis Inducing Agents
[+]

Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury.Aug 13, 2015

Pubmed Data : World J Gastroenterol. 2015 Aug 14 ;21(30):9079-92. PMID: 26290634
Article Published Date : Aug 13, 2015
Study Type : Animal Study
Additional Links
Substances : Red Sage, Safflower
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy
[+]

Red sage (764-3) prevents right ventricular collagen deposition induced by hypoxia (low oxygen) and has a therapeutic effect on monocrotaline -induced pulmontary hypertension in rats. Feb 01, 1998

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Feb;18(2):97-100. PMID: 11367654
Article Published Date : Feb 01, 1998
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Pulmonary Hypertension, Right Ventricular Hypertrophy
Pharmacological Actions : Calcium Channel Blockers
Additional Keywords : Plant Extracts
[+]

Red sage (danshen) and magnesium sulfate injection appears to reduce autoimmune sensitivity in rabbits with lumbar intervertebral disc herniation. Oct 01, 2009

Pubmed Data : Zhongguo Gu Shang. 2009 Oct;22(10):773-5. PMID: 19902761
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Magnesium, Magnesium Sulfate, Red Sage
Diseases : Herniated Disc, Intervertebral Disk Displacement
[+]

Red sage (Radix Salviae M.) could affect the procollagens expression to enhance the healing of bone fracture. Apr 01, 2000

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Apr;20(4):269-71. PMID: 11789264
Article Published Date : Apr 01, 2000
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Bone Fractures
[+]

Red sage (Radix Salviae M.) increases the strength of fracture healing site.Jan 05, 2007

Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 11783293
Article Published Date : Jan 05, 2007
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Bone Fractures
[+]

Red sage (S. miltiorrhiza) has a protective effect on adriamycin-induced cardiac and liver toxicity in rats. Dec 01, 2007

Pubmed Data : Phytother Res. 2007 Dec;21(12):1146-52. PMID: 17639557
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Chemotherapy-Induced Toxicity: Adriamycin
[+]

Red sage (Salvia miltiorrhiza) contains a compound which inhibits the gastric proton pump, reducing acid production and lesions. Aug 01, 1990

Pubmed Data : Planta Med. 1990 Aug;56(4):360-3. PMID: 2173008
Article Published Date : Aug 01, 1990
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Acid Reflux, Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Proton Pump Inhibitor
[+]

Red Sage (salviae milltiorrhize) contains a compound with potent activity against pulmonary fibrosis.Aug 01, 1992

Pubmed Data : Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1992 Aug;14(4):250-6. PMID: 1282093
Article Published Date : Aug 01, 1992
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Interstitial Lung Diseases
[+]

Red sage and curcumin exhibit anti-liver fibrotic properties. Sep 01, 2006

Pubmed Data : Chin J Integr Med. 2006 Sep;12(3):207-11. PMID: 17005083
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin, Red Sage
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antiproliferative , Vasodilator Agents
Additional Keywords : Plant Extracts
[+]

Red sage contains a compound salvianolic acid B which compares favorably to benazepril in the treatment of chronic myocardial infarction in rats.Sep 01, 2008

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2008 Sep;378(3):311-22. Epub 2008 May 24. PMID: 18500511
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Myocardial Infarction
Pharmacological Actions : Antioxidants, Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords : Drug: Benazepril, Natural Substance Synergy, Superiority of Natural Substances versus Drugs
[+]

Red sage contains a compound salvianolic acid B which compares favorably to benazepril in the treatment of chronic myocardial infarction in rats. - Article 2. May 01, 2008

Pubmed Data : Pharmacol Rep. 2008 May-Jun;60(3):369-81. PMID: 18622062
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Myocardial Infarction
Pharmacological Actions : Antihypertensive Agents, Vascular Endothelial Growth Factor Regulator
Additional Keywords : Drug: Benazepril, Natural Substance Synergy, Superiority of Natural Substances versus Drugs
[+]

Red sage extract may have therapeutic activity in reducing hypoxia-induced pulmonary hypertension.May 01, 2003

Pubmed Data : Chin Med J (Engl). 2003 May;116(5):757-60. PMID: 12875696
Article Published Date : May 01, 2003
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Hypertension: Pulmonary, Hypoxia
[+]

Red sage may have a protective effect in preventing damage associated with liver transplant. Sep 01, 2010

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Sep;14(9):765-9. PMID: 18504224
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Organ Transplantation: Liver
[+]

Salvia miltiorrhiza (red sage) protects against the lethal toxicity of endotoxin via reduction of tumor necrosis factor alpha release and liver injury. May 01, 2006

Pubmed Data : Int Immunopharmacol. 2006 May;6(5):750-8. Epub 2005 Dec 6. PMID: 16546705
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Sepsis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Salvia miltiorrhiza and Carthamus tinctorius extract prevents cardiac fibrosis and dysfunction after myocardial infarction.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:6479136. Epub 2019 May 30. PMID: 31275414
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Red Sage, Safflower
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Salvianolic acid A attenuates early brain injury after subarachnoid hemorrhage.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(12):5643-5652. Epub 2017 Dec 15. PMID: 29312516
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Salvianolic acid A could be a candidate compound for the prevention of ischemic tissue damage.Jan 30, 2018

Pubmed Data : Am J Physiol Renal Physiol. 2018 Jan 31. Epub 2018 Jan 31. PMID: 29384417
Article Published Date : Jan 30, 2018
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Ischemia
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Salvianolic acid B ameliorates cognitive deficits in a vascular dementia model.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;43(4):1381-1391. Epub 2017 Oct 9. PMID: 28992623
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Salvianolic acid B attenuates lipopolysaccharide induced acute lung injury.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Jul ;14(1):759-764. Epub 2017 Jun 1. PMID: 28672996
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Salvianolic acid B can decrease oxidative stress reaction and play a therapeutic role in the treatment of NASH.Dec 06, 2017

Pubmed Data : Arch Med Res. 2017 Dec 7. Epub 2017 Dec 7. PMID: 29224910
Article Published Date : Dec 06, 2017
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Salvianolic acid B exerted beneficially cardioprotective effects on myocardial ischemia injury rats.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Afr J Tradit Complement Altern Med. 2016 ;13(4):157-161. Epub 2016 Jul 3. PMID: 28852731
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Myocardial Ischemia, Oxidative Stress
Pharmacological Actions : Cardioprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Salvianolic acid B inhibits high-fat diet-induced inflammation by activating the Nrf2 pathway.Jul 31, 2017

Pubmed Data : J Food Sci. 2017 Aug ;82(8):1953-1960. Epub 2017 Jul 28. PMID: 28753232
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : High Fat Diet, Inflammation, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Salvianolic acid B protects against acute lung injury in a model of sepsis.Dec 31, 2017

Pubmed Data : J Cell Biochem. 2018 Jan ;119(1):701-711. Epub 2017 Aug 2. PMID: 28636082
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Lung Injury: Acute, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Salvianolic acid B protects against doxorubicin induced cardiac apoptosis and endoplasmic reticulum stress.Jul 04, 2017

Pubmed Data : Toxicol Lett. 2017 Jul 5 ;276:21-30. Epub 2017 May 8. PMID: 28495616
Article Published Date : Jul 04, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response.Dec 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2017 Dec 6 ;14(1):239. Epub 2017 Dec 6. PMID: 29212498
Article Published Date : Dec 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Depression, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
[+]

Salvianolic acid C significantly ameliorated the progression of aortic aneurysm in mice.Nov 30, 2016

Pubmed Data : Life Sci. 2016 Dec 1 ;166:75-81. Epub 2016 Sep 20. PMID: 27663582
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Polyphenols, Red Sage
Diseases : Aneurysm: Aortic
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Tanshinone IIA attenuates the development of elastase-induced experimental abdominal aortic aneurysms.Sep 30, 2012

Pubmed Data : Zhonghua Wai Ke Za Zhi. 2012 Oct ;50(10):923-7. PMID: 23302465
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Aneurysm: Aortic
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Tanshinone IIA, a compound found within Red Sage, has potential anti-cancer activity that is stronger than tamoxifen in both ER-positive and ER-negative breast cancers.Dec 01, 2009

Pubmed Data : Int J Mol Med. 2009 Dec;24(6):773-80. PMID: 19885617
Article Published Date : Dec 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Red Sage
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Drug: Tamoxifen, Superiority of Natural Substances versus Drugs
[+]

Tanshinone IIA, a compound found within Red Sage, protects against sudden cardiac death induced by lethal arrhythmias. Nov 01, 2009

Pubmed Data : Br J Pharmacol. 2009 Nov;158(5):1227-35. Epub 2009 Sep 23. PMID: 19775284
Article Published Date : Nov 01, 2009
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Cardiac Arrhythmias, Cardiac Mortality
Pharmacological Actions : Cardioprotective
[+]

Tanshinone, a compound found within Salviae mitiorrhizae (Red Sage), may prevent restenosis after artery injury. Jan 01, 2009

Pubmed Data : Altern Ther Health Med. 2009 Jan-Feb;15(1):60-7. PMID: 16780164
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Restenosis
[+]

Tanshinone, a compound from within Red Sage, protects against experimental diabetic nephropathy. Feb 01, 2009

Pubmed Data : Biol Pharm Bull. 2009 Feb;32(2):220-4. PMID: 19182379
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Diabetes: Kidney Function
[+]

Tanshinone, an extract of Salvia miltiorrhiza, has anticancer activity against estrogen postive and negative breast cancer.Sep 20, 2005

Pubmed Data : Int J Cancer. 2005 Sep 20;116(5):799-807. PMID: 15849732
Article Published Date : Sep 20, 2005
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Breast Cancer
[+]

The combination of salvianolic acid B and ginsenoside Rg1 may provide potential protection against myocardial infarction.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Chin Med Assoc. 2015 Feb ;78(2):114-20. Epub 2014 Dec 1. PMID: 25476150
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Ginsenosides, Red Sage
Diseases : Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

The present study indicate that acute treatment with an extract of S. miltiorrhiza roots exerted robust anxiolytic effects.Dec 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Chin Med Assoc. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29287701
Article Published Date : Dec 25, 2017
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Anxiety
Pharmacological Actions : Anti-Anxiety Agents
Additional Keywords : Plant Extracts
[+]

The renoprotective effect exerted by Salvianolic acid B can be attributed to its antioxidant and anti-inflammatory.May 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2017 May 15 ;50(6):e5954. Epub 2017 May 15. PMID: 28513773
Article Published Date : May 14, 2017
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Inflammation, Ischemia, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results demonstrated that salvianolic acid A held great potential for aortic aneurysm therapy.Sep 14, 2014

Pubmed Data : Phytomedicine. 2014 Sep 15 ;21(10):1137-45. Epub 2014 Jun 7. PMID: 24916705
Article Published Date : Sep 14, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Aortic Aneurysm
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

A botanical extract inhibits cell proliferation, induces apoptosis, and suppresses CCL5 in human endometriotic stromal cells.Aug 01, 2009

Pubmed Data : Biol Reprod. 2009 Aug;81(2):371-7. Epub 2009 Apr 29. PMID: 19403929
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Angelica, Boswellia, Cinnamon, Corydalis Yanhusuo, Licorice, Peony, Red Sage
Diseases : Endometriosis
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

A compound within Red Sage (tanshinone) induces programmed cell death in monocyte leukemia cells.Jan 01, 2010

Pubmed Data : Int J Mol Sci. 2010;11(6):2267-80. Epub 2010 May 26. PMID: 20640151
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Telomerase Inhibitor
[+]

Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza roots.Aug 09, 2018

Pubmed Data : J Ethnopharmacol. 2018 Aug 10 ;222:201-207. Epub 2018 May 9. PMID: 29751125
Article Published Date : Aug 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ligustrazine, an alkaloid found within Ligusticum, and Red Sage (saliva m.) are more effective than hydrocortisone in reducing collagengene expression in rat pulmonary fibrosis. Jan 01, 1999

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jan;22(1):43-5. PMID: 11812356
Article Published Date : Jan 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Ligusticum wallichii , Red Sage
Diseases : Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Oxazole-containing diterpenoids from cell cultures of Salvia miltiorrhiza and their anti-HIV-1 activities.Dec 21, 2017

Pubmed Data : J Nat Prod. 2017 Dec 22 ;80(12):3241-3246. Epub 2017 Nov 29. PMID: 29185738
Article Published Date : Dec 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : HIV Infections
Pharmacological Actions : Anti-Retroviral Agents
[+]

Present data demonstrated that treatment with Salvia miltiorrhiza ligustrazine was able to reverse the DOX resistance of SHG44/DOX cells.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Oct ;14(4):4708-4714. Epub 2017 Aug 18. PMID: 29085470
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Cancers: Drug Resistant, Glioma
Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Multidrug Resistance Gene Modulators
[+]

Red sage (Salvia miltiorrhiza) inhibits proliferation of breast cancer cells. Jul 16, 2009

Pubmed Data : Phytother Res. 2009 Jul 16. PMID: 19610045
Article Published Date : Jul 16, 2009
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
[+]

Red sage contains compounds with antifibrotic activity that may prove useful in the treatment of systemic sclerosis. Sep 11, 2007

Pubmed Data : : Zhonghua Yi Xue Za Zhi. 2007 Sep 11;87(34):2426-8. PMID: 18036324
Article Published Date : Sep 11, 2007
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Scleroderma, Scleroderma: Systemic
Pharmacological Actions : Fibrinolytic Agents
[+]

Red sage increases dopamine release in an in vitro study. Mar 01, 2006

Pubmed Data : Phytother Res. 2006 Mar;20(3):191-9. PMID: 16521109
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Dopamine Deficiency, Parkinson's Disease
Pharmacological Actions : Dopaminergic
[+]

Salvia miltiorrhiza and Panax Ginseng could be as a potential option for lung cancer treatment.Nov 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 24 ;8(60):101599-101613. Epub 2017 Sep 28. PMID: 29254189
Article Published Date : Nov 23, 2017
Study Type : In Vitro Study
Additional Links
Substances : Panax Ginseng, Red Sage
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Salvianolic acid A inhibits the invasion and migration of oral squamous cell carcinoma.Jan 30, 2018

Pubmed Data : Environ Toxicol. 2018 Jan 31. Epub 2018 Jan 31. PMID: 29385302
Article Published Date : Jan 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Salvianolic Acid A is a novel anti-cancer candidate through targeting ETAR.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(8). Epub 2016 Aug 2. PMID: 27490540
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Cervical Cancer, Lung Cancer, Prostate Cancer
Pharmacological Actions : Antiproliferative
[+]

Salvianolic acid A might be a promising therapeutic agent for the treatment of diabetic nephropathy.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;44(6):2378-2394. Epub 2017 Dec 18. PMID: 29262395
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Salvianolic acid B improves airway hyperresponsiveness.Jan 30, 2018

Pubmed Data : Eur J Pharmacol. 2018 Jan 31 ;824:30-39. Epub 2018 Jan 31. PMID: 29382534
Article Published Date : Jan 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 downregulation
[+]

Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis.Dec 31, 2017

Pubmed Data : Biochem Biophys Res Commun. 2018 01 1 ;495(1):325-331. Epub 2017 Nov 4. PMID: 29108993
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Feb ;15(2):2679-2685. Epub 2017 Dec 13. PMID: 29434992
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Salvianolic acid B, a compound found within red sage, and vitamin C work synergistically to enhance embyronic stem cell differentiation into cardiomyocytes.Oct 02, 2009

Pubmed Data : Biochem Biophys Res Commun. 2009 Oct 2;387(4):723-8. Epub 2009 Jul 28. PMID: 19643081
Article Published Date : Oct 02, 2009
Study Type : In Vitro Study
Additional Links
Substances : Red Sage, Vitamin C
Diseases : Myocardial Infarction, Stem Cell Transplant
Additional Keywords : Drug Synergy, myocardial regeneration
[+]

Salvianolic acid induces cell apoptosis and suppresses tumor growth in acute myeloid leukemia.Nov 21, 2017

Pubmed Data : Leuk Lymphoma. 2017 Nov 22:1-9. Epub 2017 Nov 22. PMID: 29164984
Article Published Date : Nov 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Tanshinones from red sage are strong inhibitors of SARS-coronavirus infection and replication.Oct 01, 2012

Pubmed Data : Bioorg Med Chem. 2012 Oct 1 ;20(19):5928-35. Epub 2012 Aug 2. PMID: 22884354
Article Published Date : Oct 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Coronavirus Disease (Covid-19), Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Tanshinones, an extract of Salvia miltiorrhiza, has anticancer activity against human lung cancer cell lines.Nov 01, 2008

Pubmed Data : Mol Cancer Ther. 2008 Nov;7(11):3527-38. PMID: 19001436
Article Published Date : Nov 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Lung Cancer
[+]

Tanshione IIA, a compound found within Red Sage, inhibits cell growth and induces programmed cell death in human hepatoma cell lines. Feb 21, 2007

Pubmed Data : World J Gastroenterol. 2007 Feb 21;13(7):1112-8. PMID: 17344596
Article Published Date : Feb 21, 2007
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

The present review considers the literature on the effects of botanicals on BDNF. Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2017 ;2017:5965371. Epub 2017 Dec 31. PMID: 29464125
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Ashwagandha, Bacopa, Coffee, Ginkgo biloba, Ginseng, Ginseng (Siberian), Grapes, Green Tea, Olive Oil, Perilla , Red Sage, Rhodiola (Tibetan Ginseng), Saffron
Diseases : Central Nervous System Diseases
Pharmacological Actions : Brain-derived neurotrophic factor modulator
[+]

These findings for the first time reveal the potential anti-tumor mechanism of Salvia miltiorrhiza Bunge polysaccharides.Feb 28, 2018

Pubmed Data : Int J Biol Macromol. 2018 Mar ;108:625-634. Epub 2017 Dec 9. PMID: 29233711
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Colorectal Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
Additional Keywords : Polysaccharides
[+]

This study preliminarily proved the protective effect of Salvia miltiorrhiza polysaccharides on LPS-induced RAW264.7 macrophage.Dec 31, 2017

Pubmed Data : J Interferon Cytokine Res. 2018 Jan ;38(1):29-37. PMID: 29328882
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

This study shows the potential of sage extracts to be used in the prevention or treatment of liver cancer.Dec 04, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec 5 ;85:57-67. Epub 2016 Dec 5. PMID: 27930987
Article Published Date : Dec 04, 2016
Study Type : In Vitro Study
Additional Links
Substances : Red Sage, Sage
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response, Plant Extracts

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