Reishi Mushroom

Name	AC	CK
Cancers: All	17	47
Inflammation	23	41
Oxidative Stress	15	40
Breast Cancer	20	30
Lung Cancer	16	24
Diabetes Mellitus: Type 2	12	21
Liver Cancer	15	21
Alzheimer's Disease	11	20
Herpes Zoster	2	20
Shingles	2	20
Breast Cancer: Triple Negative	12	18
Atherosclerosis	5	16
High Fat Diet	8	16
Colorectal Cancer	11	15
Depression	8	14
Lipopolysaccharide-Induced Toxicity	11	13
Radiation Induced Illness	2	12
Brain Inflammation	7	11
Cancer Metastasis	6	11
Prostatic Hyperplasia: Benign	2	11
Chemically-Induced Liver Damage	5	10
Chemotherapy-Induced Toxicity	1	10
Cold Sore	1	10
Endothelial Dysfunction	1	10
Focal segmental glomerulosclerosis (FSGS)	1	10
HSV-2	1	10
Herpes Genitalis	1	10
Macular Degeneration	1	10
Obesity	5	10
Osteopenia	1	10
Post-Herpetic Neuralgia	1	10
Chemotherapy-Induced Toxicity: Cisplatin	5	9
Colitis	5	9
Hyperlipidemia	5	9
Neurodegenerative Diseases	7	9
Alcoholic Liver Disease	4	8
Colon Cancer	4	8
Rheumatoid Arthritis	5	8
Aging	5	7
Arthritis	4	7
Cervical Cancer	5	7
Cognitive Decline/Dysfunction	4	7
Dyslipidemias	3	6
Hypercholesterolemia	3	6
Insulin Resistance	2	6
Melanoma	4	6
Prostate Cancer	6	6
Alcohol Toxicity	3	5
Cardiovascular Diseases	4	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Cholangiocarcinoma	1	5
Crohn's Disease	1	5
Dysbiosis	3	5
Gastric Cancer	3	5
Leukemia	4	5
Liver Fibrosis	3	5
Nonalcoholic fatty liver disease (NAFLD)	3	5
Cadmium Poisoning	2	4
Chemotherapy and Radiation Toxicity	2	4
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	4
Chemotherapy-Induced Toxicity: 5-fluorouracil	2	4
DNA damage	3	4
Diabetic Nephropathy	2	4
Epstein-Barr Virus Infections	3	4
Fatigue	2	4
Glioma	3	4
Hydrogen Peroxide Induced Toxicity	3	4
Pancreatitis	2	4
Polycystic Kidney Diseases	2	4
Sepsis	2	4
Wound Healing	2	4
Anxiety	2	3
Bladder Cancer	3	3
Coronavirus Disease (Covid-19)	2	3
Dengue	3	3
Diabetes Mellitus: Type 1	2	3
Diabetic Complications	2	3
Epilepsy	3	3
Glioblastoma	2	3
Hyperglycemia	2	3
Ischemia	2	3
Liver Damage	2	3
Lymphoma	2	3
Muscle Atrophy	1	3
Osteoporosis	2	3
Parkinson's Disease	2	3
Periodontitis	1	3
Pseudomonas aeruginosa	3	3
Sarcoidosis	1	3
Skin Cancer	2	3
Androgen-Induced Diseases	2	2
Asthma	1	2
Brain: Microglial Activation	1	2
Breast Cancer: Inflammatory	1	2
Cancers: Drug Resistant	2	2
Cancers: Multi-Drug Resistant	2	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Cerebral Hypoperfusion	1	2
Cerebral Ischemia	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Coronavirus Infection	1	2
Cysts	1	2
Duodenal Ulcer	1	2
Erectile Dysfunction	1	2
Esophageal Cancer	2	2
Formaldehyde Toxicity	1	2
Fungal Infection	1	2
Gastric Ulcer	1	2
Gastric Ulcers	1	2
Gastrointestinal Inflammation	1	2
Gestational Diabetes	1	2
HIV Infections	2	2
Hepatitis B	1	2
Hyperuricemia	1	2
Hypoxia	1	2
Ischemia: Myocardial	1	2
Kidney Cancer	2	2
Kidney Damage: Chemically-Induced	1	2
Lead Poisoning	1	2
Lipid Peroxidation	1	2
Liver Cancer: Prevention	1	2
Lung Damage	1	2
Lung Injury: Acute	1	2
Multi-Organ Failure	1	2
Mycobacterium Tuberculosis	1	2
Myocardial Ischemia	1	2
Osteosarcoma	2	2
Ovarian Cancer	2	2
Pneumonia	1	2
Polycystic Ovary Syndrome	1	2
Pulmonary Cancer	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Sleep Disorders	1	2
Staphylococcus epidermidis	2	2
Stroke: Attenuation/Recovery	1	2
Systemic Lupus Erythematosus	1	2
Ulcerative Colitis	1	2
Ultraviolet Radiation Induced Damage	2	2
Acetaminophen (Tylenol) Toxicity	1	1
Acute Myeloid Leukemia	1	1
Advanced Glycation End products (AGE)	1	1
Arthritis: Rheumatoid	2	1
Brain: Oxidative Stress	1	1
Breast Cancer: Drug Resistant	1	1
Breast Cancer: Lung Metastasis	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Carcinoma: Small Cell Lung	1	1
Cataract	1	1
Central Nervous System Diseases	1	1
Chronic Kidney Disease (CKD)	1	1
Coxsackievirus Infections	1	1
Degenerative Disk Disease	1	1
Diabetes: Oxidative Stress	1	1
Endometrial Cancer	1	1
Escherichia coli Infections	1	1
Gastrointestinal Diseases	1	1
Hepatoma: Multidrug Resistant	1	1
Influenza	1	1
Influenza A	1	1
Influenza B	1	1
Kidney Damage	1	1
Laryngeal Cancer	1	1
Leukemia: T-cell prolymphocytic leukemia (T-PLL)	1	1
Liver Damage: Drug-Induced	1	1
Lyme Disease	1	1
Metabolic Diseases	1	1
Multiple Myeloma	1	1
Neurological Disorders	1	1
Neutropenia: Chemotherapy Induced	1	1
Oral Cancer	1	1
Pancreatic Cancer	1	1
Radiation Disaster Associated Toxicity	1	1
Respiratory Infections	1	1
Rhinovirus Infection	1	1
Salmonella Infections	1	1
Schistosomiasis	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Stroke	1	1
Testosterone-Induced	1	1
Tongue Cancer	1	1
Toxoplasma gondii Infection	1	1

Name	AC	CK
Antioxidants	66	135
Anti-Inflammatory Agents	80	134
Antiproliferative	53	68
Apoptotic	47	59
Tumor Necrosis Factor (TNF) Alpha Inhibitor	26	53
Gastrointestinal Agents	21	46
Hepatoprotective	20	45
Interleukin-6 Downregulation	22	41
Immunomodulatory	23	40
Chemotherapeutic	14	39
Neuroprotective Agents	26	38
NF-kappaB Inhibitor	19	37
Hypolipidemic	16	30
Anti-Apoptotic	17	24
Anti-metastatic	17	24
Antineoplastic Agents	12	22
Interleukin-1 beta downregulation	14	22
Cardioprotective	11	18
Chemopreventive	11	17
Chemoprotective Agents	10	17
Hypoglycemic Agents	11	16
Cell cycle arrest	11	15
Antidepressive Agents	8	14
Anti-Fibrotic	7	13
Antiviral Agents	11	13
Osteoprotective	3	13
Analgesics	2	11
Chemosensitizer	7	11
Cyclooxygenase 2 Inhibitors	9	11
Malondialdehyde Down-regulation	6	10
Renoprotective	6	10
Superoxide Dismutase Up-regulation	6	10
Anticarcinogenic Agents	4	7
Bcl-2 protein down-regulation	4	7
Cyclin D1 Down-Regulation	4	7
MicroRNA modulator	5	7
Anti-Bacterial Agents	6	6
Cytotoxic	4	5
Gastroprotective	3	5
Radioprotective	3	5
Anti-atherogenic	2	4
Anticholesteremic Agents	2	4
Autophagy Up-regulation	2	4
Glutathione Upregulation	2	4
Interleukin-10 upregulation	2	4
Transforming growth factor beta (TGF-β) upregulation	2	4
Anti-Anxiety Agents	2	3
Antiparasitic Agents	3	3
Insulin Sensitizers	1	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	3
Neurogenesis	2	3
Nitric Oxide Inhibitor	2	3
Prophylactic Agents	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
5-alpha reductase inhibitor	2	2
Angiogenesis Inhibitors	2	2
Anti-Tumor	1	2
Anti-Ulcer Agents	1	2
Antihypertensive Agents	2	2
Bcl-xL down-regulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Catalase Up-Regulation	1	2
Enzyme Inhibitors	1	2
Genoprotective	2	2
Interleukin-1 alpha downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-8 downregulation	2	2
Nrf2 activation	2	2
P21 Activation	1	2
Protein tyrosine phosphatase 1B (PTP1B) modulator	1	2
SIRT1 Activator	1	2
Topoisomerase I inhibitor	1	2
Topoisomerase II Inhibitor	1	2
Transforming growth factor beta (TGF-β) inhibitor	1	2
Uricosuric Agents	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Angiogenic	1	1
Anti-Glycation Agents	1	1
Anticholinergic	1	1
Anticonvulsants	1	1
Antimicrobial	1	1
Antinoceceptive	1	1
Chondroprotective	1	1
Estrogen Receptor Modulators	1	1
Gene Protective	1	1
HIV Protease Inhibitors	1	1
Heme oxygenase-1 up-regulation	1	1
Hypnotics and Sedatives	1	1
Immunostimulatory	1	1
Interleukin-10 downregulation	1	1
Interleukin-12 upregulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Pancreato Protective Agents	1	1
Photoprotective	1	1
Radiosensitizer	1	1
STAT3 Inhibitor	1	1
Telomerase Inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Vasoprotective	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

C. versicolor and G. lucidum related natural products might have potential benefits on the overall survival and quality of life in cancer patients.Dec 31, 2018

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Pubmed Data : Front Pharmacol. 2019 ;10:703. Epub 2019 Jul 3. PMID: 31333449

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis

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Substances : Coriolus versicolor, Reishi Mushroom

Diseases : Cancers: All

Pharmacological Actions : Chemotherapeutic

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A combination of geranium extract, Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis, improve the condition of cancer patients receiving chemotherapy/radiotherapy. Jun 01, 2009

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Pubmed Data : Phytother Res. 2009 Jun;23(6):785-90. PMID: 19145638

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Pubmed Data : Food Funct. 2021 Feb 1. Epub 2021 Feb 1. PMID: 33521800

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Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.Dec 31, 2021

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Pubmed Data : Am J Cancer Res. 2022 ;12(3):1282-1294. Epub 2022 Mar 15. PMID: 35411244

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Pubmed Data : Exp Gerontol. 2023 May ;175:112147. Epub 2023 Mar 28. PMID: 36925084

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Pubmed Data : Int J Oncol. 2017 May ;50(5):1541-1554. Epub 2017 Mar 29. PMID: 28358412

Article Published Date : Apr 30, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Reishi Mushroom

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Plant Extracts

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A water-soluble extract of Reishi mushroom inhibits the development of lung tumors in rats. Dec 01, 2006

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Pubmed Data : Oncol Rep. 2006 Dec;16(6):1181-7. PMID: 17089035

Article Published Date : Dec 01, 2006

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Lung Cancer, Pulmonary Cancer

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Pubmed Data : BMC Complement Altern Med. 2016 Dec 3 ;16(1):500. Epub 2016 Dec 3. PMID: 27912745

Article Published Date : Dec 02, 2016

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : High Fat Diet, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

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Pubmed Data : Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID: 25221864

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

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Substances : Antrodia camphorata, Chaga Mushroom (Inonotus obliquus), Phellinus Linteus, Reishi Mushroom

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation

Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs

[+]

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Pubmed Data : J Affect Disord. 2024 May 7 ;358:270-282. Epub 2024 May 7. PMID: 38723681

Article Published Date : May 06, 2024

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet.Mar 31, 2022

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Ganoderma lucidum fruiting body extracts inhibit colorectal cancer.Dec 31, 2019

Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs.Jan 25, 2020

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[+]

Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease.Dec 31, 2023

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Pubmed Data : J Food Biochem. 2020 Jan ;44(1):e13109. Epub 2019 Dec 3. PMID: 31793675

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : High Fat Diet, Hyperlipidemia

Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic

Additional Keywords : Polysaccharides

[+]

[+]

Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice.Jan 14, 2019

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Pubmed Data : Food Chem. 2019 Jan 15 ;271:148-156. Epub 2018 Jul 18. PMID: 30236660

Article Published Date : Jan 14, 2019

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Alcoholic Liver Disease, Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

[+]

High-pressure supercritical CO2 extracts of Ganoderma lucidum fruiting body and their anti-hepatoma effects.Dec 31, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Aug ;26(23):23967-23980. Epub 2019 Jun 20. PMID: 31222655

Article Published Date : Jul 31, 2019

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Cadmium Poisoning , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Problem Substances : Cadmium

[+]

Quercetin synergistically inhibit Epstein-Barr virus-associated gastric carcinoma with Ganoderma lucidum extracts.Oct 23, 2019

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Pubmed Data : Molecules. 2019 Oct 24 ;24(21). Epub 2019 Oct 24. PMID: 31653035

Article Published Date : Oct 23, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Quercetin, Reishi Mushroom

Diseases : Epstein-Barr Virus Infections, Gastric Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance Synergy, Plant Extracts, Risk Reduction

[+]

Regulatory effects of Ganoderma lucidum, Grifola frondosa, and American ginseng extract formulation on gut microbiota and fecal metabolomics.Oct 16, 2023

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Pubmed Data : Biosci Biotechnol Biochem. 2017 Jun 29:1-9. Epub 2017 Jun 29. PMID: 28661219

Article Published Date : Jun 28, 2017

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Chemopreventive, Gastrointestinal Agents

Additional Keywords : Microbiota

[+]

Reishi may have therapeutic value in the treatment of Sjogren's syndrome.Mar 05, 2009

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Pubmed Data : Chin Med J (Engl). 2009 Mar 5;122(5):556-60. PMID: 19323907

Article Published Date : Mar 05, 2009

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Pharmacological Actions : Apoptotic

[+]

Reishi mushroom extract demonstrated cardioprotective properties through antioxidant effects. Mar 31, 2015

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Pubmed Data : Bull Exp Biol Med. 2015 Apr ;158(6):739-41. Epub 2015 Apr 22. PMID: 25896590

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Pubmed Data : Molecules. 2024 May 16 ;29(10). Epub 2024 May 16. PMID: 38792209

Article Published Date : May 15, 2024

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Colon Cancer, Liver Cancer, Lung Cancer

Pharmacological Actions : Antineoplastic Agents

Additional Keywords : Polysaccharides

[+]

Suppression of cisplatin-induced hepatic injury in rats through alarmin high-mobility group box-1 pathway by Ganoderma lucidum.Dec 31, 2019

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Pubmed Data : Drug Des Devel Ther. 2020 ;14:2335-2353. Epub 2020 Jun 11. PMID: 32606602

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum.Mar 14, 2021

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Pubmed Data : Carbohydr Polym. 2021 Mar 15 ;256:117594. Epub 2021 Jan 4. PMID: 33483079

Article Published Date : Mar 14, 2021

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents

[+]

The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.May 29, 2024

The present study indicated the protective efficacy of Ganoderma lucidum pharmacopuncture against ethanol induced gastric ulcer in SD rats.Feb 28, 2015

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Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:9703682. Epub 2021 Feb 3. PMID: 33613827

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Multi-Organ Failure

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Polysaccharides

[+]

Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice.Mar 04, 2016

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Pubmed Data : Chem Biol Interact. 2016 Mar 5 ;247:30-8. Epub 2016 Jan 27. PMID: 26826268

Article Published Date : Mar 04, 2016

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Pancreatitis

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

[+]

Triterpene-loaded microemulsion using adlay seed extract as oil phase for enhanced antitumor efficacy.Dec 31, 2013

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Pubmed Data : J Food Sci Technol. 2017 Oct ;54(11):3724-3730. Epub 2017 Sep 7. PMID: 29051668

Article Published Date : Sep 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Pseudomonas aeruginosa, Staphylococcus epidermidis

Pharmacological Actions : Alpha-amylase inhibitor, Anti-Bacterial Agents, Antioxidants

[+]

A glucose-enriched polysaccharide from Ganoderma lucidum suppresses tongue cancer cells.Nov 02, 2021

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Pubmed Data : Int J Biol Macromol. 2021 Nov 3. Epub 2021 Nov 3. PMID: 34742847

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Pubmed Data : Biosci Biotechnol Biochem. 2020 Aug 16:1-8. Epub 2020 Aug 16. PMID: 32799731

Article Published Date : Aug 15, 2020

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Apoptotic, Pancreato Protective Agents

[+]

A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer.Aug 27, 2023

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Pubmed Data : Int J Mol Sci. 2023 Jun 14 ;24(12). Epub 2023 Jun 14. PMID: 37373268

Article Published Date : Jun 13, 2023

Study Type : Review

Additional Links

Substances : Cordyceps Militaris, Cordyceps sinensis, Oyster Mushroom, Reishi Mushroom, Shiitake Mushroom , Turkey Tail Mushroom

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents

[+]

Anti-inflammatory effects of Ganoderma lucidum sterols via attenuation of the p38 MAPK and NF-κB pathways in LPS-induced RAW 264.7 macrophages.Feb 21, 2021

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Pubmed Data : Food Chem Toxicol. 2021 Feb 22:112073. Epub 2021 Feb 22. PMID: 33631283

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Pubmed Data : Int J Med Mushrooms. 2018 ;20(12):1173-1183. PMID: 30806298

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Biosynthesis Consideration: Reishi mushroom as a potent elicitor. Sep 08, 2010

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Pubmed Data : J Agric Food Chem. 2010 Sep 8;58(17):9518-22. PMID: 20687553

Article Published Date : Sep 08, 2010

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom, Resveratrol

Additional Keywords : Stilbenes

[+]

Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.Aug 14, 2019

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Pubmed Data : Int J Biol Macromol. 2019 Aug 15 ;135:706-716. Epub 2019 May 23. PMID: 31129213

Article Published Date : Aug 14, 2019

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Hyperlipidemia

Pharmacological Actions : Antioxidants, Hypolipidemic, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Polysaccharides

[+]

Chlorella and Ganoderma lucidum exhibited highly synergistic effects in most of the examined antioxidant and anti-inflammatory parameters.May 09, 2018

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Pubmed Data : Pharmazie. 2016 Jun ;71(6):340-4. PMID: 27455554

Article Published Date : May 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Epilepsy

Pharmacological Actions : Anti-Apoptotic, Anticonvulsants, Neuroprotective Agents

[+]

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Pubmed Data : J Pharm Pharmacol. 2024 Apr 3 ;76(4):354-367. PMID: 38330446

Pubmed Data : Acta Pharmacol Sin. 2008 May;29(5):620-7. PMID: 18430371

Article Published Date : May 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Cancers: Multi-Drug Resistant, Leukemia

[+]

Ganoderma lucidum could be a potential cardioprotective agent.Dec 31, 2015

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Pubmed Data : Oncoscience. 2016 ;3(7-8):203-207. Epub 2016 Aug 28. PMID: 27713910

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Pubmed Data : J Cancer. 2016 ;7(5):500-11. Epub 2016 Feb 5. PMID: 26958085

Ganoderma polysaccharides treatment may serve as a novel strategy for antiphotoaging.Dec 31, 2016

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Additional Keywords : Gene Expression Regulation

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Immunostimulatory effects of a subcritical water extract of Ganoderma.Dec 31, 2022

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Pubmed Data : Biomed Rep. 2023 Jan ;18(1):1. Epub 2022 Nov 9. PMID: 36544853

Article Published Date : Dec 31, 2022

Study Type : In Vitro Study

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Substances : Reishi Mushroom

Pharmacological Actions : Immunostimulatory

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Improvement of Echinacea purpurea and Ganoderma lucidum extracts with cell model on influenza A/B infection.Jul 29, 2024

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Pubmed Data : Molecules. 2024 Jul 30 ;29(15). Epub 2024 Jul 30. PMID: 39125012

Article Published Date : Jul 29, 2024

Study Type : In Vitro Study

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Substances : Echinacea, Reishi Mushroom

Diseases : Influenza A, Influenza B

Pharmacological Actions : Antiviral Agents

Additional Keywords : Plant Extracts

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In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts.May 17, 2023

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Pubmed Data : Semin Cancer Biol. 2015 Apr 9. Epub 2015 Apr 9. PMID: 25865774

Article Published Date : Apr 08, 2015

Study Type : Review

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Substances : Agaricus Blazei, Cordyceps Militaris, Medicinal Mushrooms, Milk Thistle, Poria cocos, Reishi Mushroom

Diseases : Cancer Metastasis, Cancers: All

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Meroterpenoid dimers from Ganoderma mushrooms and their biological activities against triple negative breast cancer cells.Dec 31, 2021

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Pubmed Data : Front Chem. 2022 ;10:888371. Epub 2022 May 3. PMID: 35592305

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Reishi Mushroom

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Cytotoxic

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Mushroom polysaccharides are efficacious in ameliorating the immune suppression in the tumor microenvironment.Dec 31, 2014

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Pubmed Data : Biomed Res Int. 2015 ;2015:604385. Epub 2015 Jun 17. PMID: 26167490

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Polysaccharide peptide from grass-cultured Ganoderma lucidum induces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line.Mar 31, 2018

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Pubmed Data : Oncol Lett. 2018 Apr ;15(4):4330-4336. Epub 2018 Jan 19. PMID: 29541200

Article Published Date : Mar 31, 2018

Study Type : In Vitro Study

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Substances : Reishi Mushroom

Diseases : Glioma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Polysaccharides

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Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation.Mar 23, 2017

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Pubmed Data : Adv Exp Med Biol. 2019 ;1182:181-199. PMID: 31777019

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Substances : Reishi Mushroom

Diseases : Cardiovascular Diseases

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardioprotective, Hypolipidemic

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Recombinant Ganoderma lucidum immunomodulatory protein improves the treatment for chemotherapy-induced neutropenia.Dec 31, 2019

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Pubmed Data : Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1607-12. PMID: 9810695

Article Published Date : Oct 01, 1998

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : HIV Infections

Pharmacological Actions : HIV Protease Inhibitors

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Reishi (Ganoderma lucidum) has anticancer activity in human urothelial cells. Jan 01, 2008

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Pubmed Data : Nutr Cancer. 2008;60(1):109-19. PMID: 18444142

Article Published Date : Jan 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Bladder Cancer

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View the Evidence: 349 Abstracts with Reishi Mushroom Research

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C. versicolor and G. lucidum related natural products might have potential benefits on the overall survival and quality of life in cancer patients.Dec 31, 2018

A combination of geranium extract, Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis, improve the condition of cancer patients receiving chemotherapy/radiotherapy. Jun 01, 2009

A mushroom formula containing Reishi (Ganoderma) has therapeutic activity against herpes genitalis and labialis.Nov 01, 2007

A mushroom formula containing Reishi (Ganoderma) reduces pain in patients with Herpes zoster.Jan 01, 2005

Beta glucan found in reishi mushroom is a potent antioxidant against pathogenesis of atherosclerosis in stable angina and high risk patients.Oct 01, 2018

Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

Effects of Macuprev® supplementation in age-related macular degeneration.Aug 31, 2019

Fermentation of Pleurotus ostreatus and Ganoderma lucidum mushrooms and their extracts by the gut microbiota of healthy and osteopenic women.Jan 31, 2021

Reishi (Ganoderma lucidum) safely improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Sep 01, 2008

Reishi (Ganoderma) has significant therapeutic value in patients with FSGS. Jan 01, 2004

Reishi reduces pain from postherpetic neuralgia. Mar 01, 2006

The present intervention demonstrated the antioxidation, anti-aging and hepatoprotective nature of Ganoderma lucidum.Nov 30, 2017

This study demonstrates that β-glucans from G. lucidum increase the frequency of immune system cells in the peripheral blood.Dec 31, 2017

An extract of G. lucidum spores suppressed cholangiocarcinoma migration in vitro through inhibition of TGF-β1-induced EMT.May 14, 2016

Ganoderic acids suppress growth and invasive behavior of breast cancer cells.Apr 30, 2008

Triterpene ganoderic acid inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation.May 18, 2015

A patient with annular cutaneous sarcoidosis showed almost complete regression of lesions.Feb 29, 2016

Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum.Aug 07, 2023

Ganoderic acid A enhances tumor suppression function of oxaliplatin via inducing the cytotoxicity of T cells.Dec 31, 2022

Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity.Jun 24, 2018

Ganoderic acid A promotes amyloid-β clearance and ameliorates cognitive deficiency in Alzheimer's disease.May 23, 2021

Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.Dec 31, 2023

Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.Dec 31, 2021

Proteoglycan extracted from Ganoderma lucidum ameliorated diabetes-induced muscle atrophy.Aug 21, 2023

These results provide the evidence for the beneficial effects of G. lucidum on periodontitis.Dec 31, 2023

Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins.Apr 30, 2023

Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1.Sep 23, 2021

A polysaccharide from the mycelia of G. lucidum might be used as functional agent to regulate the intestinal barrier functions.Sep 28, 2016

A proteoglycan isolated from Ganoderma lucidum attenuates diabetic kidney disease.Jun 27, 2023

A reishi extract ameliorates the colon precancerous lesions induced by AOM and the small-intestinal injury caused by 5-FU.May 31, 2013

A water extract of broken spores of G. lucidum possesses chemopreventive potential in colorectal cancer.Apr 30, 2017

A water-soluble extract of Reishi mushroom inhibits the development of lung tumors in rats. Dec 01, 2006

A. brasiliensis and G. lucidum have pronounced antioxidant properties. Dec 31, 2014

Acetic acid and Reishi mushroom polysaccharide contain lifespan-promoting activity in the nematode. Nov 15, 2009

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.Nov 17, 2022

Administration of medicinal mushrooms under experimental diabetes showed a positive corrective action on the L-arginine/NO system and the ratio between p53 and Bcl-2 proteins.Dec 31, 2014

Alcohol extracts from Ganoderma lucidum delay the progress of Alzheimer's disease.Dec 31, 2018

Amauroderma rude could inhibit cancer cell survival and induce apoptosis, also there were fewer and smaller colonies than the untreated cells.Dec 31, 2012

An ethanol extract of sporoderm-broken spores of G. lucidum suppressed the growth of human lung cancer.Sep 30, 2016

Anti-cancer effects of a neutral triterpene fraction from Ganoderma lucidum and its active constituents on SW620 human colorectal cancer cells.Oct 13, 2019

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum.May 31, 2006

Anti-inflammatory and intestinal microbiota modulation properties of Ganoderma lucidum β-d-glucans.Aug 17, 2023

Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity.Jul 31, 2021

Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.Dec 31, 2012

Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor.Nov 30, 2021

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.Dec 31, 2018

Antitumor and immunomodulatory activities of Ganoderma lucidum polysaccharides in glioma-bearing rats.Feb 28, 2018

Antitumor effects of different Ganoderma lucidum spore powder in cell- and zebrafish-based bioassays.Jan 12, 2021

Beta glucans reduces inflammation in obese mice fed a high-cholesterol diet.Dec 02, 2016

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

Codonopsis pilosula polysaccharide in synergy with dacarbazine inhibits mouse melanoma by repolarizing M2-like tumor-associated macrophages into M1-like tumor-associated macrophages.Aug 08, 2021

Effect of the Lingzi or Reishi medicinal mushroom Ganoderma lucidum on hyperglycemia and dyslipidemia.Dec 31, 2022

Effects and mechanism of Ganoderma lucidum polysaccharides in the treatment of diabetic nephropathy.Dec 31, 2021

Effects of molecular weight on intestinal anti-inflammatory activities of β-D-glucan from Ganoderma lucidum.Dec 31, 2021

G. lucidum aqueous extract protects against some of the deleterious effects of lead ingestion.Dec 31, 2018

G. lucidum could be suggested as a medicotherapeutic agent against Alzheimer's disease. Dec 31, 2019

G. lucidum polysaccharides could serve as a regenerative agent for the treatment of cognitive decline associated with neurodegenerative diseases.Jan 09, 2017

Ganoderic acid A against cyclophosphamide-induced hepatic toxicity. Mar 31, 2019

Ganoderic acid A alleviated the depressive-like behaviors and brain inflammation in post-stroke depression.Dec 31, 2020

Ganoderic acid A alleviates myocardial ischemia-reperfusion injury. Jun 30, 2020

Ganoderic acid A alleviates OVA-induced asthma in mice. Sep 30, 2021

Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms.May 06, 2024

Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet.Mar 31, 2022

Ganoderic acid A attenuates high-fat-diet-induced liver injury.Jun 30, 2020

Ganoderic acid A attenuates lipopolysaccharide-induced lung injury.Jan 30, 2019

Ganoderic acid A exerted antidepressant-like action through FXR modulated NLRP3 inflammasome and synaptic activity.Dec 31, 2020

Ganoderic acid A from G. lucidum has the potential to alleviate lipid metabolic disorders and ameliorate the imbalance of gut microflora in a positive way.Jul 31, 2020

Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury.May 22, 2022

Ganoderic acid A inhibits bleomycin-induced lung fibrosis.Dec 31, 2019

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease.May 31, 2020

Ganoderic acid A To alleviate neuroinflammation of Alzheimer's disease.Nov 30, 2021

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury.Dec 31, 2021

Reishi Mushroom

View the Evidence:
349 Abstracts with Reishi Mushroom Research