Saffron

Name	AC	CK
Depression	28	294
Diabetes Mellitus: Type 2	9	56
Anxiety	6	53
Erectile Dysfunction	4	40
Alzheimer's Disease	13	33
Obesity	3	32
Overweight	3	30
Liver Damage	3	24
Macular Degeneration	6	24
Cardiovascular Diseases	4	23
Hyperglycemia	3	23
Hyperlipidemia	2	21
Depression: Postpartum	2	20
Sexual Dysfunction: SSRI-induced	2	20
Anxiety Disorders	4	18
Hypertension	5	16
Glaucoma	5	15
Depressive Disorder	3	12
Diabetic Complications	2	12
Oxidative Stress	7	11
Premenstrual syndrome	2	11
Stroke: Ischemic	2	11
Appetite Disorders	1	10
Attention Deficit Hyperactivity Disorder	1	10
Dysmenorrhea	1	10
Fibromyalgia	1	10
High Cholesterol	1	10
Hot Flash	1	10
Lower Urinary Tract Symptoms	1	10
Maculopathy: Age-Related	1	10
Menopausal Syndrome	1	10
Mood Disorders	1	10
Prediabetes	1	10
Premenstrual Dysphoric Disorder	1	10
Psoriasis	1	10
Sexual Arousal Disorder	1	10
Weight Probems: Appetite	1	10
Breast Cancer	6	8
Inflammation	5	8
Cancers: All	7	7
Cerebral Ischemia	3	6
Atherosclerosis	4	5
Neurodegenerative Diseases	4	5
Neuropathic Pain	3	5
Parkinson's Disease	3	5
Alcohol Toxicity	2	4
Burns	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Cognitive Decline/Dysfunction	3	4
Colorectal Cancer	3	4
Liver Cancer	3	4
Liver Damage: Drug-Induced	2	4
Middle Cerebral Artery Occlusion (MCAO)	2	4
Multiple Sclerosis	3	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Wound Healing	2	4
Diabetic Retinopathy	2	3
Eye Diseases	3	3
Ischemia	2	3
Metabolic Syndrome X	3	3
Pesticide Toxicity	2	3
Respiratory Diseases	2	3
Aging: Liver	1	2
Alcohol Withdrawal	1	2
Aluminum Toxicity	2	2
Anorexia: Stress-Induced	1	2
Anxiety: Generalized	1	2
Asthma	2	2
Athletic Performance	1	2
Brain: Oxidative Stress	1	2
Breast Cancer: Triple Negative	1	2
Cardiac Hypertrophy	1	2
Cervical Cancer	2	2
Chemically-Induced Liver Damage	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Liver Toxicity	1	2
Chemotherapy-Induced Toxicity	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Coronavirus Infection	2	2
DNA damage	1	2
Delayed Sleep Phase Disorder	1	2
Dementia	2	2
Diabetes Mellitus: Type 1	1	2
Diabetic Neuropathy	1	2
Drug Toxicity: Isoprenaline	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Excitotoxicity	1	2
Hypothyroidism	1	2
Insomnia	1	2
Insulin Resistance	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Leishmaniasis	2	2
Leukemia	2	2
Lipopolysaccharide-Induced Toxicity	1	2
Low Libido	1	2
Memory Disorders	2	2
Obsessive-Compulsive Disorder	1	2
Opiate Addiction/Withdrawal	1	2
Pancreatic Cancer	2	2
Sleep Disorders	1	2
Tremor	1	2
Triglycerides: Elevated	1	2
Tuberculosis Drug Induced Toxicity	1	2
Acetaminophen (Tylenol) Toxicity	1	1
Arthritis	1	1
Autoimmune Diseases	1	1
Bronchitis	1	1
Cadmium Poisoning	1	1
Cancer Metastasis	1	1
Candida Infection	1	1
Cardiovascular Disease	1	1
Central Nervous System Diseases	1	1
Chemical Poisoning: Accumulated Environmental Toxins	1	1
Colon Cancer	1	1
Common Cold	1	1
Coronary Artery Disease	1	1
Dermatitis	1	1
Dyslipidemias	1	1
Endothelial Damage	1	1
Fever	1	1
Glioma	1	1
Helicobacter Pylori Infection	1	1
Infertility	1	1
Inflammatory Bowel Diseases	1	1
Learning disorders	1	1
Lung Cancer	1	1
Maculopathy	1	1
Melanoma	1	1
Myocardial Ischemia	1	1
Oral Cancer	1	1
Osteoarthritis	1	1
Osteosarcoma	1	1
Plasmodium Infections	1	1
Retinitis Pigmentosa	1	1
Schizophrenia	1	1
Seizures	1	1
Skin Cancer	1	1
Squamous cell carcinoma	1	1
Asthenozoospermia	1	0
Infertility: Male	1	0

Name	AC	CK
Antidepressive Agents	29	313
Hypoglycemic Agents	14	84
Antioxidants	31	67
Anti-Anxiety Agents	9	61
Neuroprotective Agents	27	48
Anti-Inflammatory Agents	24	37
Antihypertensive Agents	7	35
Hepatoprotective	9	35
Cardioprotective	10	33
Hypolipidemic	8	31
Anticholesteremic Agents	3	22
Enzyme Inhibitors	1	20
Antiproliferative	11	14
Chemopreventive	10	13
Anti-Apoptotic	6	10
Ergogenic	1	10
Interleukin-6 Downregulation	5	8
Apoptotic	6	7
Malondialdehyde Down-regulation	4	7
Anti-metastatic	5	6
Chemotherapeutic	5	6
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	6
Immunomodulatory	4	5
Cyclooxygenase 2 Inhibitors	3	4
Interleukin-1 beta downregulation	3	4
Superoxide Dismutase Up-regulation	2	4
Analgesics	2	3
Antinoceceptive	2	3
Chemoprotective Agents	2	3
Insulin Sensitizers	2	3
Nitric Oxide Inhibitor	2	3
Prophylactic Agents	2	3
Adiponectin upregulation	1	2
Anti-atherogenic	1	2
Anticarcinogenic Agents	2	2
Antiviral Agents	2	2
Aphrodisiac	1	2
Autophagy Up-regulation	2	2
Bronchodilator Agents	1	2
Calcium Channel Blockers	1	2
Cardiovascular Agents	1	2
Catalase Up-Regulation	1	2
Cell cycle arrest	2	2
Cyclooxygenase Inhibitors	1	2
Excitatory Amino Acid Agonists	1	2
Gastroprotective	1	2
Glutathione Upregulation	1	2
Hypnotics and Sedatives	1	2
Hypotensive	1	2
Interleukin-10 upregulation	1	2
Interleukin-17 downregulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Prostaglandin Antagonists	1	2
Radioprotective	1	2
Renoprotective	1	2
Acetylcholinesterase Inhibitor	1	1
Anti-Angiogenic	1	1
Anti-Bacterial Agents	1	1
Anticonvulsants	1	1
Antimicrobial	1	1
Antimutagenic Agents	1	1
Antiparasitic Agents	1	1
Brain-derived neurotrophic factor modulator	1	1
Chemosensitizer	1	1
Cytoprotective	1	1
Interleukin-12 downregulation	1	1
Leishmanicidal	1	1
NF-kappaB Inhibitor	1	1
Nootropic Agents	1	1
Phase II Detoxification Enzyme Inducer	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Vasodilator Agents	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Effect of Crocus sativus and crocin in the treatment of patients with type-2 diabetes mellitus.Sep 28, 2023

Meta-analysis: Saffron (Crocus sativus L.) has value in treating major depressive disorder.Oct 31, 2013

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Pubmed Data : J Integr Med. 2013 Nov ;11(6):377-83. PMID: 24299602

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Pubmed Data : Neuropsychiatr Dis Treat. 2018 ;14:1297-1305. Epub 2018 May 21. PMID: 29849461

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Pubmed Data : Psychol Res Behav Manag. 2019 ;12:297-305. Epub 2019 Apr 23. PMID: 31118846

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Saffron

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Fluoxetine (trade name Prozac)

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The present meta-analysis suggests that saffron might be beneficial in several outcomes related with cardiovascular disease.Nov 27, 2018

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Pubmed Data : Pharmacol Res. 2018 Nov 28 ;139:348-359. Epub 2018 Nov 28. PMID: 30502528

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Pubmed Data : J Evid Based Complementary Altern Med. 2015 May 6. Epub 2015 May 6. PMID: 25948674

Article Published Date : May 05, 2015

Study Type : Human Study

Additional Links

Substances : Saffron

Diseases : Diabetic Complications, Erectile Dysfunction

Additional Keywords : Significant Treatment Outcome

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Crocus sativus compares favorably in the treatment of mild to moderate depression. Feb 27, 2005

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Pubmed Data : J Ethnopharmacol. 2005 Feb 28 ;97(2):281-4. Epub 2005 Jan 6. PMID: 15707766

Article Published Date : Feb 27, 2005

Study Type : Human Study

Additional Links

Substances : Saffron

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substances Versus Drugs, Phytotherapy, Plant Extracts

Problem Substances : Fluoxetine (trade name Prozac)

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Crocus sativus in the treatment of female sexual dysfunction.Apr 30, 2022

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Saffron hydroalcoholic extract may improve blood glucose control by reducing fasting blood sugar in T2D patients.Dec 31, 2017

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Pubmed Data : Arch Gynecol Obstet. 2018 03 ;297(3):717-724. Epub 2018 Jan 13. PMID: 29332222

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Saffron

Diseases : Depression, Hot Flash

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Phytotherapy, Plant Extracts

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Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction.Sep 30, 2012

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Pubmed Data : Psychopharmacology (Berl). 2012 Oct ;223(4):381-8. Epub 2012 May 3. PMID: 22552758

Article Published Date : Sep 30, 2012

Pubmed Data : Clin Nutr ESPEN. 2019 Dec ;34:130-136. Epub 2019 Aug 16. PMID: 31677703

Pubmed Data : J Affect Disord. 2015 Mar 15 ;174:51-6. Epub 2014 Nov 26. PMID: 25484177

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Pubmed Data : J Food Biochem. 2020 Jul 21:e13391. Epub 2020 Jul 21. PMID: 32696531

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Pubmed Data : Phytother Res. 2009 Jun;23(6):768-74. PMID: 19142981

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Pubmed Data : J Food Biochem. 2019 Aug ;43(8):e12946. Epub 2019 Jun 20. PMID: 31368566

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Saffron

Diseases : Athletic Performance

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Saffron extract attenuates anxiogenic effect and improves cognitive behavior in an model of traumatic brain injury.Sep 30, 2022

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Pubmed Data : Int J Mol Sci. 2022 Oct 1 ;23(19). Epub 2022 Oct 1. PMID: 36232902

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Pubmed Data : Z Naturforsch C. 2014 Nov-Dec;69(11-12):459-70. PMID: 25854766

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Pubmed Data : Neurotoxicology. 2015 Dec 17 ;52:230-242. Epub 2015 Dec 17. PMID: 26705857

Article Published Date : Dec 16, 2015

Study Type : Insect Study

Additional Links

Substances : Crocin, Saffron

Diseases : Neurodegenerative Diseases, Oxidative Stress, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity.Oct 31, 2021

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Pubmed Data : Rep Biochem Mol Biol. 2021 Jan ;9(4):426-434. PMID: 33969136

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These findings indicated that C. sativus L. had a protective effect against intestinal injury.Nov 30, 2016

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Pubmed Data : Mol Med Rep. 2016 Dec ;14(6):5601-5606. Epub 2016 Nov 15. PMID: 27878268

Article Published Date : Nov 30, 2016

Study Type : Insect Study

Additional Links

Substances : Saffron

Pharmacological Actions : Gastroprotective

[+]

These results validate the use of saffron as a treatment against diabetes mellitus and its vascular complications.Mar 31, 2017

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Pubmed Data : Antioxidants (Basel). 2020 Nov 9 ;9(11). Epub 2020 Nov 9. PMID: 33182461

Article Published Date : Nov 08, 2020

Study Type : In Vitro Study

Additional Links

Substances : Saffron

Diseases : Cardiovascular Diseases

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Anti-cancer effects of traditional medicinal herbs on oral squamous cell carcinoma.Jan 31, 2020

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[+]

Crocus sativus causes a non apoptotic calpain dependent death in C6 rat glioma cells, exhibiting a synergistic effect with temozolomide.Dec 31, 2018

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Pubmed Data : Nutr Cancer. 2019 ;71(3):491-507. Epub 2018 Oct 1. PMID: 30273051

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Pubmed Data : Biomed Res Int. 2022 ;2022:4740246. Epub 2022 Jun 10. PMID: 35722462

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Saffron

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

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Current Knowledge of the antidepressant activity of chemical compounds from Crocus sativus.Dec 29, 2022

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Findings from initial clinical trials suggest that saffron may improve the symptoms and the effects of depression, premenstrual syndrome, sexual dysfunction and infertility, and excessive snacking behaviors.Jun 30, 2015

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Pubmed Data : Med Sci Sports Exerc. 2020 Jul ;52(7):1470-1476. PMID: 31977642

Prospects of saffron and its derivatives in Alzheimer's disease. Feb 28, 2021

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Pubmed Data : Arch Iran Med. 2021 Mar 1 ;24(3):233-252. Epub 2021 Mar 1. PMID: 33878882

Article Published Date : Feb 28, 2021

Study Type : Review

Additional Links

Substances : Saffron

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Click here to read the entire abstract

Pubmed Data : Rev Invest Clin. 2002 Sep-Oct;54(5):430-6. PMID: 12587418

Article Published Date : Sep 01, 2002

Study Type : Commentary

Additional Links

Substances : Saffron

Diseases : Cancers: All

Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, Chemopreventive

[+]

Saffron extract has protective effects against aluminum-induced apoptosis and oxidative stress.Dec 31, 2019

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Pubmed Data : Iran J Med Sci. 2020 Jan ;45(1):59-66. PMID: 32038060

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Saffron

Diseases : Aluminum Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

Problem Substances : Aluminum

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Saffron has an extensive spectrum of protective properties against toxicities induced by either natural or chemical toxins.Dec 31, 2014

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Pubmed Data : Urol J. 2008 Fall;5(4):255-9. PMID: 19101900

Article Published Date : Sep 01, 2008

Additional Links

Substances : Saffron

Diseases : Asthenozoospermia, Infertility: Male

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View the Evidence: 261 Abstracts with Saffron Research

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Effect of Crocus sativus and crocin in the treatment of patients with type-2 diabetes mellitus.Sep 28, 2023

Effect of saffron and fenugreek on lowering blood glucose.Apr 30, 2023

Effects of saffron on anthropometric and cardiometabolic indices in overweight and obese patients.Jul 21, 2022

Effect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.Oct 11, 2021

Effect of saffron supplementation on oxidative stress parameters.Sep 30, 2021

Meta-analysis: Saffron (Crocus sativus L.) has value in treating major depressive disorder.Oct 31, 2013

Saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.Feb 03, 2020

Saffron could be an effective intervention for symptoms of depression and anxiety.May 27, 2019

Saffron could be considered as an alternative to synthetic antidepressants in the treatment of mild to moderate depression.Mar 31, 2020

Saffron could be considered as an alternative to synthetic antidepressants in the treatment of mild to moderate depression.Jan 06, 2020

Saffron has a significant effect on the severity of depression.Jul 22, 2018

Saffron supplementation can reduce ALT serum concentrations without significant effects on other liver function indicators.Mar 15, 2021

Saffron supplementation may significantly improve both systolic and diastolic blood pressure in adults.Aug 08, 2021

Saffron was effective in the treatment of major depressive disorder and had comparable efficacy to synthetic antidepressants.Dec 31, 2017

Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis.Oct 28, 2021

The available evidence indicates that saffron is a safe plant for administration as a medicine and can improve diverse clinical outcomes.Aug 07, 2021

The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism.Feb 29, 2020

The findings of this study showed that saffron administration was well comparable with fluoxetine and placebo.Dec 31, 2018

The present meta-analysis suggests that saffron might be beneficial in several outcomes related with cardiovascular disease.Nov 27, 2018

These results provide further validation of the sleep-enhancing effects of 28-days of saffron supplementation in adults with unsatisfactory sleep.Aug 10, 2021

A Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.May 01, 2010

A hydroalcoholic Saffron extract has beneficial effects in patients with type 2 diabetes mellitus.Apr 02, 2019

Administration of saffron capsules was comparable with memantine in reducing cognitive decline in patients with moderate to severe AD.Jun 30, 2014

An Edgar Cayce fashioned diet may prove effective in the treatment of psoriasis,Sep 01, 2004

An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults.Dec 31, 2021

An herbal combination of saffron, celery seed and anise is more effective than the drug mefenamic acid (NSAID) in relieving menstrual pain. Sep 01, 2009

Compared to placebo, the prepared saffron gel could significantly improve erectile dysfunction in diabetic patientsMay 05, 2015

Crocus sativus compares favorably in the treatment of mild to moderate depression. Feb 27, 2005

Crocus sativus in the treatment of female sexual dysfunction.Apr 30, 2022

Impact of saffron supplementation and resistance training on markers implicated in depression and happiness levels.Feb 05, 2021

Improvement of inflammatory status following saffron and resistance training in elderly hypertensive men.May 31, 2022

It seems saffron may safely and effectively improve some of the fluoxetine-induced sexual problems including arousal, lubrication, and pain.Dec 31, 2012

Jollab beverage has significant positive effects on reducing fatigue in women with breast cancer.Dec 31, 2021

Oral aqueous saffron extract seems to exert an ocular hypotensive effect in primary open-angle glaucoma.Oct 14, 2014

Pine Bark Extract, Saffron, Saw Palmetto for three months significantly improved sexual function, urinary symptoms.Aug 31, 2016

Role of aromatic herbs and spices in salty perception of patients with hyposmia.Nov 22, 2022

Saffron (at least in the short term) is both safe and effective in mild to moderate AD. Oct 01, 2010

Saffron and duloxetine demonstrated comparable efficacy in treatment of fibromyalgia symptoms.Oct 31, 2018

Saffron appears to be a powerful antidepressant for older people, who might be more reluctant to the use of synthetic drugs.Oct 11, 2019

Saffron appears to have a significant impact in the treatment of anxiety and depression disorders.May 31, 2016

Saffron capsules may help reduce the symptoms of depression in patients who experience mild or moderate depression and are overweight.Oct 09, 2019

Saffron capsules showed the same antidepressant efficacy compared with fluoxetine in patients with a prior history of PCI who were suffering from depression.Jan 31, 2014

Saffron compares favorably to donepezil in the treatment of mild-to-moderate Alzhemier's disease.Jan 01, 2010

Saffron could be a safe alternative medication for improving depressive symptoms of postpartum depression.Feb 28, 2017

Saffron extract appears to improve subclinical depressive symptoms in healthy individuals.Dec 31, 2019

Saffron extract could be a natural and safe nutritional strategy to improve sleep duration and quality.Apr 26, 2021

Saffron has a positive effect on sexual function in patients with ED. Aug 01, 2009

Saffron has beneficial effects on depression and homocysteine level in patients with major depression.Dec 31, 2017

Saffron hydroalcoholic extract may improve blood glucose control by reducing fasting blood sugar in T2D patients.Dec 31, 2017

Saffron improves life and sleep quality, glycaemic status, lipid profile and liver function in diabetic patients.May 06, 2021

Saffron in combination with resistance training reduced blood pressure in the elderly hypertensive men.Jan 25, 2021

Saffron is a safe and effective treatment in improving hot flashes and depressive symptoms in post-menopausal healthy women.Dec 31, 2017

Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction.Sep 30, 2012

Saffron is efficacious in the treatment of premenstrual syndrome. Dec 01, 2005

Saffron may be of therapeutic benefit in the treatment of mild to moderate depression and has similar efficacy as the drug imipramine. Sep 02, 2004

Saffron may change some hematological and biochemical parameters, but is generally safe and tolerable in healthy adults. Oct 01, 2009

Saffron supplementation could improve glycemic and antioxidant indices in overweight/obese individuals with prediabetes.Nov 30, 2019

Saffron supplementation improves retinal flicker sensitivity in early AMD.Nov 30, 2010

Saffron supplementation was also possibly responsible for improvement of muscle blood perfusion and facilitation in the oxygen transport.Dec 31, 2015

Saffron was an efficacious herbal agent for the treatment of premenstrual dysphoric disorder with minimal adverse effects.Dec 31, 2019

Saffron was beneficial in women with postpartum depression.Nov 30, 2017

Short-term therapy with saffron capsule showed the same efficacy compared with methylphenidate in patients with attention-deficit/hyperactivity disorder.Mar 31, 2019

The administration of a standardised saffron extract may improve anxiety and depressive symptoms.Dec 31, 2017

The anti-dyslipidemia property of saffron petal hydroalcoholicextract in cardiovascular patients.May 31, 2023

The combination of rhodiola and saffron could be useful for the management of mild-moderate depression and improve depressive and anxiety symptoms.Dec 31, 2017

The effects of saffron in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers.Jan 08, 2022

The herbal remedies examined had significantly beneficial effects on cholesterol in T2D patients.Aug 31, 2014

The results indicate the beneficial effect of saffron on the mild to moderate comorbid depression- anxiety in type 2 diabetic patients.Nov 30, 2018

The results of the study demonstrate that the Aphrodit capsule was effective in reducing menopausal symptoms.Feb 28, 2017

The results of this study confirmed the short and long-term neuroprotective effects of aqueous extract of saffron on ischemic stroke in humans.Mar 22, 2019

The use of a food product containing Daucus carota improved all domains of sexual function in females.Mar 31, 2018

Saffron

View the Evidence:
261 Abstracts with Saffron Research