Safranal

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38 Diseases Researched for Safranal
NameACCKFocus
Oxidative Stress56Locked
Alzheimer's Disease23Locked
Allodynia12Locked
Asthma12Locked
Brain: Oxidative Stress12Locked
Cerebral Ischemia12Locked
Chemically-Induced Liver Damage12Locked
Chronic Pain12Locked
Depression12Locked
Diabetes Mellitus: Type 112Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetic Nephropathy12Locked
Epilepsy12Locked
Excitotoxicity 12Locked
Huntington Disease12Locked
Hypertension12Locked
Hyperthyroidism12Locked
Inflammation12Locked
Myocardial Ischemia12Locked
Neuropathic Pain12Locked
Parkinson's Disease12Locked
Prostate Cancer12Locked
Schizophrenia12Locked
Stroke: Attenuation/Recovery 12Locked
Cancers: All11Locked
Cervical Cancer11Locked
Colitis11Locked
Endothelial Damage11Locked
Escherichia coli Infections11Locked
Helicobacter Pylori Infection11Locked
Immune Dysregulation: TH1/TH2 imbalance11Locked
Leishmaniasis11Locked
Liver Cancer11Locked
Multiple Sclerosis11Locked
Oral Cancer11Locked
Photooxidative Stress11Locked
Plasmodium Infections11Locked
Squamous cell carcinoma11Locked
32 Pharmacological Actions Researched for Safranal
NameACCKFocus
Antioxidants1219Locked
Neuroprotective Agents713Locked
Anti-Inflammatory Agents59Locked
Anti-Apoptotic46Locked
Antiproliferative 23Locked
Chemopreventive23Locked
Interleukin-6 Downregulation23Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor23Locked
Anti-Asthmatic Agents12Locked
Anti-Bacterial Agents22Locked
Anticholesteremic Agents12Locked
Anticonvulsants12Locked
Antidepressive Agents12Locked
Antihypertensive Agents12Locked
Antinoceceptive 12Locked
Apoptotic22Locked
Cardioprotective12Locked
Excitatory Amino Acid Agonists12Locked
Hepatoprotective12Locked
Hypoglycemic Agents12Locked
Interleukin-1 beta downregulation12Locked
NF-kappaB Inhibitor12Locked
Nitric Oxide Inhibitor12Locked
Nrf2 activation12Locked
P21 Activation12Locked
Vasodilator Agents12Locked
Antiparasitic Agents11Locked
Cell cycle arrest11Locked
Immunomodulatory11Locked
Interferon-gamma (IFN-gamma) inducer11Locked
Interleukin-4 upregulation11Locked
Malondialdehyde Down-regulation11Locked

View the Evidence:
41 Abstracts with Safranal Research

[+]

Findings of blood and tissue analysis concluded that safranal can be a good choice in the management and cure of NAFLD.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm Res. 2022 ;15:1293-1316. Epub 2022 Feb 24. PMID: 35241921
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Hepatic Steatosis, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

It is recommended that safranal be considered for diabetes management.Aug 05, 2018

Pubmed Data : Biomed Pharmacother. 2018 Aug 6 ;107:203-211. Epub 2018 Aug 6. PMID: 30092399
Article Published Date : Aug 05, 2018
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

N-Acetylcysteine and Safranal prevented the brain damage induced by hyperthyroidism.Apr 06, 2020

Pubmed Data : Nutr Neurosci. 2020 Apr 7:1-15. Epub 2020 Apr 7. PMID: 32264788
Article Published Date : Apr 06, 2020
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Safranal
Diseases : Hyperthyroidism
Pharmacological Actions : Neuroprotective Agents
[+]

Safrana l prevents prostate cancer recurrence.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2020 ;8:598620. Epub 2020 Dec 16. PMID: 33392189
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Safranal
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, NF-kappaB Inhibitor, P21 Activation
[+]

Safranal alleviated OVA-induced asthma model and inhibits mast cell activation. Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2021 ;12:585595. Epub 2021 May 20. PMID: 34093515
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Safranal ameliorates myocardial ischemia.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2020 Jul ;143(3):156-164. Epub 2020 Mar 23. PMID: 32278466
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Safranal attenuates cognitive deficits in amyloid β-induced rat model of Alzheimer's disease.Aug 16, 2019

Pubmed Data : Metab Brain Dis. 2019 Aug 17. Epub 2019 Aug 17. PMID: 31422512
Article Published Date : Aug 16, 2019
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice.Jan 01, 2018

Pubmed Data : Pharmazie. 2018 04 2 ;73(4):207-212. PMID: 29609687
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Safranal has an anti-inflammatory potential and has a strong antioxidative effect.May 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : An Acad Bras Cienc. 2019 May 23 ;91(2):e20181235. Epub 2019 May 23. PMID: 31141017
Article Published Date : May 22, 2019
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Chemically-Induced Liver Damage, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Safranal inhibits angiogenesis via targeting HIF-1α/VEGF machinery.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2021 ;11:789172. Epub 2022 Feb 2. PMID: 35211395
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Safranal
Diseases : Liver Cancer
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Safranal is thought to be used as an effective combination in controlling metabolic complications caused by olanzapine.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Dec ;22(12):1476-1482. PMID: 32133067
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Schizophrenia
Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents
Problem Substances : Olanzapine
[+]

Safranal may serve as a potent and promising therapeutic drug for the treatment of Parkinson's disease.Dec 29, 2016

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2016 Dec 30 ;62(14):11-17. Epub 2016 Dec 30. PMID: 28145852
Article Published Date : Dec 29, 2016
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Safranal might be effective against depressant-like effects induced by chronic stress via modulating brain oxidative response.Aug 29, 2017

Pubmed Data : Neurosci Lett. 2017 Aug 30. Epub 2017 Aug 30. PMID: 28866053
Article Published Date : Aug 29, 2017
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Brain: Oxidative Stress, Depression
Pharmacological Actions : Antidepressive Agents, Antioxidants
[+]

Safranal pretreatment to these allergically inflamed mice lead to a significant decrease in airway hyper-responsiveness and airway cellular infiltration to the lungs.Mar 31, 2015

Pubmed Data : Phytother Res. 2015 Apr ;29(4):617-27. Epub 2015 Mar 10. PMID: 25756352
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Asthma
Pharmacological Actions : Anti-Apoptotic, Anti-Asthmatic Agents, Nitric Oxide Inhibitor
[+]

Safranal prevented the motor dysfunction induced by 3-NP in animal model of Huntington's disease.Feb 20, 2021

Pubmed Data : Neurochem Res. 2021 Feb 21. Epub 2021 Feb 21. PMID: 33611726
Article Published Date : Feb 20, 2021
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Huntington Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:777500. Epub 2022 Feb 1. PMID: 35177980
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Safranal vasodilation is mediated by the inhibition of calcium influx from extracellular space through L-type Ca2+ channels.Jun 29, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jun 30 ;27(13). Epub 2022 Jun 30. PMID: 35807473
Article Published Date : Jun 29, 2022
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Endothelial Dysfunction
Pharmacological Actions : Vasodilator Agents
[+]

Safranal, a constituent of Saffron, reduces kainic Acid treatment-induced glutamate and aspartate concentrations in the rat hippocampus. Oct 01, 2008

Pubmed Data : Planta Med. 2008 Oct;74(12):1441-5. Epub 2008 Sep 24. PMID: 18816431
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Saffron, Safranal
Diseases : Excitotoxicity
Pharmacological Actions : Excitatory Amino Acid Agonists
[+]

The relaxant activity of safranal is mediated predominantly through an endothelium independent mechanism.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2016 Dec ;19(4):329-335. PMID: 28097042
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Hypertension
Pharmacological Actions : Vasodilator Agents
[+]

The results of the present study showed neuroprotective effects of crocin, safranal and insulin in a rat model of diabetic neuropathy.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2015 Sep-Oct;5(5):469-78. PMID: 26468467
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Crocin, Safranal
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Neuroprotective Agents
[+]

This study concluded that safranal had protective effects on ischemic reperfusion injury in the rat model of stroke.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Neuropathol. 2017 ;55(3):206-213. PMID: 28984113
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Cerebral Ischemia, Stroke: Attenuation/Recovery
Pharmacological Actions : Neuroprotective Agents
[+]

This study confirmed the antiallodynia effect of safranal, main volatile fraction of saffron, in a neuropathic pain model induced by spinal nerve transaction.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2014 ;7(12):4990-6. Epub 2014 Dec 15. PMID: 25663997
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Allodynia, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents
[+]

TRPA1 mediates the antinociceptive properties of safranal.Jan 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Jan 12. Epub 2019 Jan 12. PMID: 30636360
Article Published Date : Jan 11, 2019
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

Anticancer activity of safranal against colon carcinoma is due to induction of apoptosis and G2/M cell cycle arrest.Dec 31, 2020

Pubmed Data : J BUON. 2021 Jan-Feb;26(1):297. PMID: 33721482
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Comprehensive proteomics and sialiomics of the anti-proliferative activity of safranal on triple negative MDA-MB-231 breast cancer cell lines.Feb 27, 2022

Pubmed Data : J Proteomics. 2022 Feb 28 ;259:104539. Epub 2022 Feb 28. PMID: 35240313
Article Published Date : Feb 27, 2022
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
[+]

Crocin and safranal exerted apoptotic effects in KB cell line.Jul 17, 2017

Pubmed Data : Nutr Cancer. 2017 Jul 18:1-9. Epub 2017 Jul 18. PMID: 28718677
Article Published Date : Jul 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Safranal
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic
[+]

Protective effects of saffron and its active components against oxidative stress and apoptosis in endothelial cells.Dec 31, 2017

Pubmed Data : Microvasc Res. 2018 07 ;118:82-89. Epub 2018 Mar 7. PMID: 29524452
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carotenoids, Crocin, Saffron, Safranal
Diseases : Endothelial Damage, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Additional Keywords : Plant Extracts
[+]

Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2021 Dec ;22(6):1400. Epub 2021 Oct 1. PMID: 34675994
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Myocardial Infarction
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action.Dec 23, 2020

Pubmed Data : Crit Rev Food Sci Nutr. 2020 Dec 24:1-18. Epub 2020 Dec 24. PMID: 33356506
Article Published Date : Dec 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron, Safranal
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Safranal alleviates dextran sulfate sodium-induced colitis and suppresses macrophage-mediated inflammation.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1281. Epub 2019 Nov 1. PMID: 31736758
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth.Jan 31, 2017

Pubmed Data : Int J Biol Macromol. 2017 Feb ;95:145-152. Epub 2016 Nov 16. PMID: 27865956
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Escherichia coli Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Safranal exhibits oligoprotection potential by means of inhibiting oxidative stress parameters.Nov 20, 2018

Pubmed Data : Drug Res (Stuttg). 2018 Nov 21. Epub 2018 Nov 21. PMID: 30463091
Article Published Date : Nov 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Multiple Sclerosis, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells.Nov 15, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Nov 16 ;8(1):16951. Epub 2018 Nov 16. PMID: 30446676
Article Published Date : Nov 15, 2018
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Safranal inhibits HeLa cell viability by perturbing the reassembly potential of microtubules.Oct 10, 2017

Pubmed Data : Phytother Res. 2017 Oct 11. Epub 2017 Oct 11. PMID: 29024138
Article Published Date : Oct 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative
[+]

Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization.May 17, 2021

Pubmed Data : Toxicol Appl Pharmacol. 2021 May 18 ;423:115582. Epub 2021 May 18. PMID: 34019860
Article Published Date : May 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Safranal may have therapeutic effects in inflammatory diseases associated with Th1/Th2 imbalance.Nov 30, 2016

Pubmed Data : Iran J Immunol. 2016 Dec ;13(4):263-273. PMID: 27999238
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions : Immunomodulatory, Interferon-gamma (IFN-gamma) inducer, Interleukin-4 upregulation
[+]

Safranal protects against ischemia-induced PC12 cell injury through inhibiting oxidative stress and apoptosis.Dec 31, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2021 04 ;394(4):707-716. Epub 2020 Oct 31. PMID: 33128592
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Safranal showed anti-apoptotic and antioxidant effects and may exert promising potential for the prevention of Alzheimer's disease.Nov 05, 2018

Pubmed Data : Metab Brain Dis. 2018 Nov 6. Epub 2018 Nov 6. PMID: 30402809
Article Published Date : Nov 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Safranal
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

The components of crocus sativus have potential anti-bacterial and anti-parasitic effects.Mar 12, 2015

Pubmed Data : J Enzyme Inhib Med Chem. 2015 Mar 13:1-7. Epub 2015 Mar 13. PMID: 25766747
Article Published Date : Mar 12, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Saffron, Safranal
Diseases : Helicobacter Pylori Infection, Leishmaniasis, Plasmodium Infections
Pharmacological Actions : Anti-Bacterial Agents, Antiparasitic Agents
[+]

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2021 Feb ;7(2):e06117. Epub 2021 Feb 10. PMID: 33615006
Article Published Date : Jan 31, 2021
Study Type : Review
Additional Links
Substances : Saffron, Safranal
Diseases : Oxidative Stress, Photooxidative Stress
Pharmacological Actions : Antioxidants
[+]

This review provides a brief insight into the anticancer properties of saffron and its components. Mar 31, 2015

Pubmed Data : J Tradit Complement Med. 2015 Apr ;5(2):81-7. Epub 2015 Jan 28. PMID: 26151016
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Crocetin, Crocin, Saffron, Safranal
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive

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