Saikosaponin

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49 Diseases Researched for Saikosaponin
NameACCKFocus
Lipopolysaccharide-Induced Toxicity46Locked
Chemically-Induced Liver Damage35Locked
Liver Cancer55Locked
Oxidative Stress35Locked
Cerebral Ischemia24Locked
Colitis24Locked
Depression24Locked
Hepatitis24Locked
Inflammation34Locked
Pancreatitis24Locked
Breast Cancer: Triple Negative 33Locked
Liver Fibrosis23Locked
Alzheimer's Disease12Locked
Attention Deficit Hyperactivity Disorder12Locked
Breast Cancer22Locked
Carcinoma: Non-Small-Cell Lung22Locked
Chemotherapy-Induced Toxicity: 5-fluorouracil 12Locked
Liver Damage12Locked
Lung Inflammation12Locked
Lung Injury: Acute12Locked
Lung Injury: Smoke-Induced12Locked
Neutropenia: Chemotherapy Induced12Locked
Pancreatic Fibrosis22Locked
Sexual Arousal Disorder12Locked
Spinal Cord Injuries12Locked
Ulcerative Colitis12Locked
Acute Myeloid Leukemia11Locked
Allergic Rhinitis11Locked
Cancers: Drug Resistant11Locked
Cancers: Multi-Drug Resistant11Locked
Coronavirus Disease (Covid-19)11Locked
Coronavirus Infection11Locked
Endometritis11Locked
Enterovirus 7111Locked
Glioblastoma11Locked
Hepatitis B 11Locked
Hepatitis C11Locked
Influenza11Locked
Kidney Cancer11Locked
Kidney Damage: Chemically-Induced11Locked
Kidney Fibrosis11Locked
Lung Cancer11Locked
Melanoma11Locked
Osteoarthritis11Locked
Osteosarcoma11Locked
Pancreatic Cancer11Locked
Pulmonary Fibrosis11Locked
Scars11Locked
Sciatic Nerve Crush Injury11Locked
42 Pharmacological Actions Researched for Saikosaponin
NameACCKFocus
Anti-Inflammatory Agents1929Locked
Interleukin-1 beta downregulation1219Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor916Locked
NF-kappaB Inhibitor1015Locked
Antioxidants712Locked
Antiproliferative 1010Locked
Interleukin-6 Downregulation69Locked
Apoptotic77Locked
Hepatoprotective46Locked
Neuroprotective Agents36Locked
Nrf2 activation46Locked
Anti-Apoptotic35Locked
Anti-Fibrotic55Locked
Antiviral Agents55Locked
Antidepressive Agents24Locked
Brain-derived neurotrophic factor modulator24Locked
Chemosensitizer44Locked
Cyclooxygenase 2 Inhibitors34Locked
Gastrointestinal Agents24Locked
Heme oxygenase-1 up-regulation34Locked
Chemotherapeutic23Locked
STAT3 Inhibitor33Locked
Anti-metastatic22Locked
Antineoplastic Agents22Locked
Chemoprotective Agents12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Radiosensitizer22Locked
Renoprotective22Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Autophagy Inhibitors11Locked
Autophagy Up-regulation11Locked
Cyclin D1 Down-Regulation11Locked
Immunomodulatory11Locked
Interleukin-10 upregulation11Locked
Interleukin-17 downregulation11Locked
Interleukin-18 down-regulation11Locked
Pancreato Protective Agents11Locked
STAT3 Activation11Locked
Transforming growth factor beta (TGF-β) inhibitor11Locked
Transforming growth factor beta (TGF-β) upregulation11Locked

View the Evidence:
52 Abstracts with Saikosaponin Research

[+]

Cognitive improvements and reduction in amyloid plaque deposition by saikosaponin D treatment in a murine model of Alzheimer's disease.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Aug ;20(2):1082-1090. Epub 2020 May 17. PMID: 32742347
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Curcumin and saikosaponin A inhibit chemical-induced liver inflammation and fibrosis in rats.Jul 24, 2007

Pubmed Data : Mol Vis. 2007 Jul 24;13:1291-7. PMID: 20128048
Article Published Date : Jul 24, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin, Saikosaponin
Diseases : Chemically-Induced Liver Damage, Hepatitis, Inflammation, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Inhibition of oxidative stress and NLRP3 inflammasome by Saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2020 Jan-Dec;34:2058738420950593. PMID: 32816567
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Chemically-Induced Liver Damage, Hepatitis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model.Dec 14, 2019

Pubmed Data : Life Sci. 2019 Dec 15 ;239:116888. Epub 2019 Oct 19. PMID: 31639401
Article Published Date : Dec 14, 2019
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective effects and mechanism of saikosaponin A on acute spinal cord injury.Jan 14, 2017

Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 07 15 ;31(7):825-829. PMID: 29798527
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα.Jun 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:131-137. Epub 2019 Apr 10. PMID: 30981078
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saikosaponin a ameliorates LPS-induced acute lung injury. Jan 31, 2018

Pubmed Data : Inflammation. 2018 Feb ;41(1):193-198. PMID: 28986747
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saikosaponin a attenuates hyperlipidemic pancreatitis.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Feb ;19(2):1203-1212. Epub 2019 Dec 13. PMID: 32010290
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Saikosaponin A attenuates neural injury caused by ischemia/reperfusion.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Neurosci. 2020 ;11(1):227-235. Epub 2020 Jul 2. PMID: 33335763
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saikosaponin a contributed to chemotherapy induced neutropenia treatment by promoting neutrophil bactericidal activity.Jan 31, 2021

Pubmed Data : Phytomedicine. 2021 Feb ;82:153444. Epub 2020 Dec 26. PMID: 33421903
Article Published Date : Jan 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Neutropenia: Chemotherapy Induced
Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic
[+]

Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia.Apr 08, 2021

Pubmed Data : Behav Brain Res. 2021 Apr 9 ;403:113138. Epub 2021 Jan 22. PMID: 33493495
Article Published Date : Apr 08, 2021
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Cerebral Ischemia, Depression
Pharmacological Actions : Anti-Apoptotic, Antidepressive Agents, Brain-derived neurotrophic factor modulator
[+]

Saikosaponin a inhibits cigarette smoke-induced oxidant stress and inflammatory responses.Jul 31, 2018

Pubmed Data : Inflammation. 2018 Aug ;41(4):1297-1303. PMID: 29654431
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Lung Inflammation, Lung Injury: Smoke-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saikosaponin A protects against dextran sulfate sodium-induced colitis.Jun 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:454-458. PMID: 31035087
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saikosaponin A-induced gut microbiota changes attenuate severe acute pancreatitis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:9217219. Epub 2020 Nov 1. PMID: 33204401
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Pancreatitis
Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Nrf2 activation
[+]

Saikosaponin D rescues deficits in sexual behavior and ameliorates neurological dysfunction in mice exposed to chronic mild stress.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:625074. Epub 2021 Feb 16. PMID: 33776766
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Depression, Sexual Arousal Disorder
Pharmacological Actions : Antidepressive Agents, Antioxidants
[+]

Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis.Mar 31, 2020

Pubmed Data : Int Immunopharmacol. 2020 Apr ;81:106288. Epub 2020 Feb 13. PMID: 32062075
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Colitis, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, NF-kappaB Inhibitor
[+]

The obtained result suggested that saikosaponin A may be a potential drug for treating ADHD.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:2695903. Epub 2017 Feb 15. PMID: 28293263
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Attention Deficit Hyperactivity Disorder
Pharmacological Actions : Brain-derived neurotrophic factor modulator
[+]

Anti-influenza triterpenoid saponins (saikosaponins) from the roots of Bupleurum marginatum var. stenophyllum.Jan 14, 2017

Pubmed Data : Bioorg Med Chem Lett. 2017 04 15 ;27(8):1654-1659. Epub 2017 Mar 7. PMID: 28314599
Article Published Date : Jan 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
[+]

Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1943-1951. Epub 2019 Jun 13. PMID: 31257464
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Activation
[+]

Antiviral effect of saikosaponin B2 in combination with daclatasvir on NS5A resistance-associated substitutions of hepatitis C virus.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Chin Med Assoc. 2019 May ;82(5):368-374. PMID: 30920421
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antiviral effects of saikosaponins on human coronavirus 229E in vitro.Jul 01, 2006

Pubmed Data : Clin Exp Pharmacol Physiol. 2006 Jul ;33(7):612-6. PMID: 16789928
Article Published Date : Jul 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Coronavirus Disease (Covid-19), Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Chemosensitizing effect of saikosaponin B on B16F10 melanoma cells. Mar 31, 2017

Pubmed Data : Nutr Cancer. 2017 Apr ;69(3):505-511. Epub 2017 Feb 17. PMID: 28287317
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Cancers: Drug Resistant, Melanoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer, NF-kappaB Inhibitor
[+]

Effects of Saikosaponin D on apoptosis in human U87 glioblastoma cells.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Aug ;16(2):1459-1464. Epub 2017 Jun 13. PMID: 28627659
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Saikosaponin a attenuates lead-induced kidney injury through activating Nrf2 signaling pathway.Mar 31, 2021

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr ;242:108945. Epub 2020 Dec 3. PMID: 33278595
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Lead
[+]

Saikosaponin a increases interleukin-10 expression and inhibits scar formation after sciatic nerve injury.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2018 Sep ;13(9):1650-1656. PMID: 30127128
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Scars, Sciatic Nerve Crush Injury
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation
[+]

Saikosaponin A inhibits breast cancer by regulating Th1/Th2 balance. Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:624. Epub 2019 Jun 4. PMID: 31214035
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Breast Cancer
Pharmacological Actions : Immunomodulatory
[+]

Saikosaponin A inhibits lipopolysaccharide-induced endometritis.Jul 31, 2018

Pubmed Data : Inflammation. 2018 Aug ;41(4):1508-1514. PMID: 29748729
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saikosaponin A inhibits the activation of pancreatic stellate cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Aug ;128:110216. Epub 2020 Jun 1. PMID: 32497863
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Pancreatic Fibrosis
Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents
[+]

Saikosaponin A inhibits triple-negative breast cancer growth and metastasis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2019 ;9:1487. Epub 2020 Jan 28. PMID: 32047724
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Saikosaponin A may be used as a therapeutic candidate for allergic rhinitis disease.Jan 04, 2020

Pubmed Data : Chem Biol Interact. 2020 Jan 5 ;315:108874. Epub 2019 Oct 24. PMID: 31669322
Article Published Date : Jan 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Allergic Rhinitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

Saikosaponin B2 attenuates kidney fibrosis via inhibiting the hedgehog pathway.Jan 31, 2020

Pubmed Data : Phytomedicine. 2020 Feb ;67:153163. Epub 2019 Dec 28. PMID: 31901891
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Saikosaponin B2 could be a potential therapeutic application for inflammation-associated diseases.Jan 31, 2019

Pubmed Data : Inflammation. 2019 Feb ;42(1):342-353. PMID: 30251218
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters.Aug 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life Sci. 2019 Aug 15 ;231:116557. Epub 2019 Jun 10. PMID: 31194994
Article Published Date : Aug 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Cancers: Multi-Drug Resistant, Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Chemosensitizer
[+]

Saikosaponin C exerts anti-HBV effects by attenuating HNF1α and HNF4α expression to suppress HBV pgRNA synthesis.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Inflamm Res. 2019 Dec ;68(12):1025-1034. Epub 2019 Sep 17. PMID: 31531682
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Hepatitis B
Pharmacological Actions : Antiviral Agents
[+]

Saikosaponin d ameliorates pancreatic fibrosis.Feb 24, 2019

Pubmed Data : Chem Biol Interact. 2019 Feb 25 ;300:18-26. Epub 2019 Jan 3. PMID: 30611790
Article Published Date : Feb 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Pancreatic Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) upregulation
[+]

Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m 6 A signaling.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Theranostics. 2021 ;11(12):5831-5846. Epub 2021 Mar 31. PMID: 33897884
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Chemotherapeutic
[+]

Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:724-733. Epub 2018 Sep 21. PMID: 30248540
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Saikosaponin D inhibits autophagosome‑lysosome fusion and induces autophagy‑independent apoptosis in MDA‑MB‑231 breast cancer cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Aug ;22(2):1026-1034. Epub 2020 May 18. PMID: 32468000
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Med Res. 2020 Sep ;48(9):300060520937163. PMID: 32962498
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, STAT3 Inhibitor
[+]

Saikosaponin D inhibits proliferation of human osteosarcoma cells via the p53 signaling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jan ;17(1):488-494. Epub 2018 Nov 14. PMID: 30651826
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Saikosaponin D plays an important role in anti-pulmonary fibrosis by regulating TGF-β1/Smads signalling pathway.Feb 28, 2019

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Mar ;35(3):256-261. PMID: 31030720
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Dose Response
[+]

Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Signal Transduct Target Ther. 2019;4:4. Epub 2019 Feb 22. PMID: 30820356
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Enterovirus 71
Pharmacological Actions : Antiviral Agents, Autophagy Inhibitors
[+]

Saikosaponin D was capable of suppressing tumor growth and promoting apoptosis of pancreatic cancer cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2020 ;13:9465-9479. Epub 2020 Sep 24. PMID: 33061432
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Saikosaponin D: A potential therapeutic drug for osteoarthritis.Dec 31, 2019

Pubmed Data : J Tissue Eng Regen Med. 2020 08 ;14(8):1175-1184. Epub 2020 Jul 7. PMID: 32592611
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Saikosaponin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

Saikosaponin-D enhances the sensitivity of human non-small cell lung cancer cells to gefitinib.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2019 ;10(26):6666-6672. Epub 2019 Oct 22. PMID: 31777595
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Chemosensitizer, STAT3 Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Saikosaponin-d increases radiation-induced apoptosis of hepatoma cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2021 ;18(6):1465-1473. Epub 2021 Jan 29. PMID: 33628104
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Liver Cancer
Pharmacological Actions : Autophagy Up-regulation, Radiosensitizer
[+]

Saikosaponin-d increases the radiosensitivity of hepatoma cells by adjusting cell autophagy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2019 ;10(20):4947-4953. Epub 2019 Aug 27. PMID: 31598167
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Radiosensitizer
[+]

Saikosaponin-d inhibits the hepatoma cells and enhances chemosensitivity.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1039. Epub 2019 Sep 20. PMID: 31616295
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer
[+]

Saikosaponin-d protects against liver fibrosis.May 10, 2021

Pubmed Data : Biochem Cell Biol. 2021 May 11. Epub 2021 May 11. PMID: 33974808
Article Published Date : May 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Saikosaponin-d suppresses cell growth in renal cell carcinoma.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neoplasma. 2017;64(4):518-525. PMID: 28485157
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Saikosaponin-d suppresses COX2 through p-STAT3/C/EBPβ signaling pathway in liver cancer.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:623. Epub 2019 May 29. PMID: 31191326
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors
[+]

Saikosaponin‑d alleviates carbon‑tetrachloride induced acute hepatocellular injury.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Jun ;17(6):7939-7946. Epub 2018 Apr 5. PMID: 29620210
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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