SAMe (S-adenosylmethionine)

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15 Diseases Researched for SAMe (S-adenosylmethionine)

Name	AC	CK
Depression	2	30
Osteoarthritis	3	30
Alzheimer's Disease	3	22
Fibromyalgia	1	10
Parkinson's Disease	1	10
Schizophrenia	1	10
Alcohol Toxicity	1	2
Alzheimer's Disease: Homocysteine Associated	1	2
Fatty Liver	1	2
Hemochromatosis	1	2
Liver Cancer	2	2
Vitamin B Deficiency	1	2
Demyelinating Diseases	1	1
Multiple Sclerosis	1	1
Postpartum Depression	1	1

6 Pharmacological Actions Researched for SAMe (S-adenosylmethionine)

Name	AC	CK
Antidepressive Agents	1	20
Hepatoprotective	1	2
Neuroprotective Agents	1	2
Antiproliferative	1	1
Apoptotic	1	1
Chemopreventive	1	1

Research Articles 20
Cumulative Knowledge Score 32
Overall Research Rating GOOD

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20 Abstracts with SAMe (S-adenosylmethionine) Research

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View the Evidence: 20 Abstracts with SAMe (S-adenosylmethionine) Research

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Current evidence supports adjunctive use of SAMe, methylfolate, omega-3, and vitamin D with antidepressants to reduce depressive symptoms.Apr 25, 2016

A multi-vitamin/nutrient formula has therapeutic value in early-stage Alzheimer's diease. Dec 01, 2008

A multi-vitamin/nutrient formula has therapeutic value in moderate-stage to later-stage Alzheimer's diease. Feb 01, 2009

Sam-e appears to be well tolerated and effect in the treatment of depression in Parkinson's disease.Nov 01, 2000

Sam-e improves symptoms in primary fibromyalgia.Jan 01, 1991

Sam-e significantly improves osteoarthritis symptoms and depression.Nov 20, 1987

Sam-e supplementation reduces aggressive behavior and improves quality of life in patients with schizophrenia. Jan 01, 2009

Sam-e works as good as Piroxicam, but sustained clinical improvement longer.Nov 20, 1987

Sam-e works like NSAIDs against inflammation in osteoarthritis, but is more tolerable.Nov 20, 1987

S-adenosylmethionine attenuates hepatic lipid synthesis in pigs fed alchohol with a folate deficient diet. Jul 01, 2007

S-adenosylmethionine may have a therapeutic role in the treatment of hemochromatosis.Feb 01, 2004

S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice.Jun 30, 2012

SAM plays a neuroprotective role by increasing the expression of endogenous BDNF and could be a potential target for AD therapy.Mar 31, 2016

A number of complementary/alternative therapies may have therapeutic potential in treating postpartum depression. Jan 01, 2009

Arginine and S-adenosylmethionine may contribute to nerve regeneration. Jun 01, 2008

Deficiency of dietary sources of methyl groups (e.g. methionine, choline, b12, folate, sam-e) reduce DNA methylation in the liver which leads to liver cancer.Aug 01, 2003

S-Adenosylmethionine is an attractive agent for both chemoprevention and treatment of liver cancer. Mar 01, 2008

Sam-e's potential to encourage remyelination may be of value in Multiple Sclerosis.Aug 01, 1994

Sam-e protects against azoxymethane-induced colonic abberations and suppresseshuman colon cancer cells.Jan 01, 2008

Sam-e treats depression in postmeopausal women.Jan 01, 1993

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SAMe (S-adenosylmethionine)

View the Evidence:
20 Abstracts with SAMe (S-adenosylmethionine) Research