Sesamol

Name	AC	CK
Oxidative Stress	21	35
Lipid Peroxidation	14	25
Inflammation	9	13
Lipopolysaccharide-Induced Toxicity	6	11
High Fat Diet	5	10
Obesity	4	8
Chemically-Induced Liver Damage	3	6
Chemotherapy and Radiation Toxicity	3	6
Cognitive Decline/Dysfunction	3	6
Kidney Damage	3	6
Liver Damage	3	6
Brain Inflammation	2	4
Diabetes: Cognitive Dysfunction	2	4
Huntington Disease	2	4
Hyperlipidemia	2	4
Hypertension	2	4
Inflammatory Bowel Diseases	2	4
Memory Disorders	2	4
Brain: Oxidative Stress	2	3
Chemotherapy-Induced Toxicity: Doxorubicin	2	3
Colon Cancer	2	3
DNA damage	2	3
Radiation Induced Illness	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging	1	2
Aluminum Toxicity	1	2
Arthritis	1	2
Asthma	1	2
Atherosclerosis	1	2
Blood-Brain-Barrier Disorders	1	2
Brain Damage	1	2
Candida Albicans	2	2
Cataract	1	2
Cerebral Ischemia	1	2
Colitis	1	2
Depression	1	2
Diabetic Neuropathies	1	2
Endothelial Dysfunction	1	2
Endotoxemia	1	2
Enterocolitis: Necrotiziing	1	2
Epilepsy	1	2
Gastric Ulcer	1	2
Heavy Metal Toxicity	1	2
Hepatic Steatosis	1	2
High Fructose Diet	1	2
Hyperpigmentation	1	2
Ischemia	1	2
Kidney Damage: Chemically-Induced	1	2
Lung Infection	1	2
Lung Injury: Acute	1	2
Memory Impairment: Hormone Deficiency Induced	1	2
Menopausal Syndrome	1	2
Mitochondrial Dysfunction	1	2
Myocardial Infarction	1	2
Myocardial Infarction: Prevention	1	2
Neurodegenerative Diseases	1	2
Neuropathic Pain	1	2
Pancreatitis	1	2
Parkinson's Disease	1	2
Postmenopausal Disorders: Memory Impairment	1	2
Radiation Disaster Associated Toxicity	1	2
Respiratory Infections	1	2
Sepsis	1	2
Sinusoidal obstruction syndrome	1	2
Skin Cancer	1	2
Stroke: Ischemic	1	2
Triglycerides: Elevated	1	2
Ultraviolet Radiation Induced Damage	1	2
Wound Healing	1	2
Anemia	1	1
Cancers: All	1	1
Candida Infection	1	1
Cardiovascular Diseases	1	1
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	1
Freckles	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Liver Cancer	1	1
Lung Cancer	1	1
Melanoma	1	1
Melasma	1	1
Osteoporosis	1	1
Progesterone: Low	1	1
Skin Diseases: Photo-Aging	1	1
Staphylococcus aureus infection	1	1
Statin-Induced Pathologies	1	1
Streptococcus pneumoniae infection	1	1
Testicular Cancer	1	1
Tuberculosis: Drug Resistant	1	1

Name	AC	CK
Antioxidants	38	67
Neuroprotective Agents	14	27
Anti-Inflammatory Agents	15	26
Tumor Necrosis Factor (TNF) Alpha Inhibitor	10	17
Hepatoprotective	6	12
Radioprotective	6	11
Apoptotic	8	10
Renoprotective	5	10
Gastroprotective	4	8
Glutathione Upregulation	4	8
Interleukin-1 beta downregulation	5	7
Anti-Apoptotic	3	6
NF-kappaB Inhibitor	4	6
Cardioprotective	3	5
Cyclooxygenase 2 Inhibitors	3	5
Interleukin-6 Downregulation	3	5
Chemopreventive	2	4
Chemoprotective Agents	3	4
Hypolipidemic	2	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	4
Nrf2 activation	3	4
Anti-Adipogenic	2	3
Antiproliferative	3	3
Nitric Oxide Inhibitor	2	3
Prostaglandin PGE2 downregulation	2	3
Superoxide Dismutase Up-regulation	2	3
Anti-atherogenic	1	2
Anticarcinogenic Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Antifungal Agents	2	2
Antihypertensive Agents	1	2
Bcl-2 protein down-regulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Caspase-3 Inhibition	1	2
Catalase Up-Regulation	1	2
Chondroprotective	1	2
Cyclooxygenase Inhibitors	1	2
Enzyme Inhibitors	1	2
Malondialdehyde Down-regulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Mitochondrial Superoxide Dismutase Upregulation	1	2
Photoprotective	1	2
Anti-Bacterial Agents	1	1
Antimicrobial	1	1
Antineoplastic Agents	1	1
Autophagy Inhibitors	1	1
Cell cycle arrest	1	1
Lipoxygenase Inhibitors	1	1
Pancreato Protective Agents	1	1
Secretagogue	1	1
Steroidogenesis	1	1
Tyrosinase Inhibition	1	1

[+]

Sesamol attenuates renal inflammation and arrests reactive-oxygen-species-mediated IL-1β secretion.Dec 13, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2022 Dec 14 ;11(12). Epub 2022 Dec 14. PMID: 36552668

Article Published Date : Dec 13, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sesamol

Diseases : Chronic Kidney Disease (CKD)

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective

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ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders.Jun 04, 2019

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Pubmed Data : J Agric Food Chem. 2019 Jun 5 ;67(22):6190-6201. Epub 2019 May 28. PMID: 31117496

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Pubmed Data : Mol Nutr Food Res. 2010 Sep ;54(9):1340-50. PMID: 20306475

Article Published Date : Sep 01, 2010

Study Type : Animal Study

Additional Links

Substances : Lignans, Sesamol

Diseases : Atherosclerosis, Endothelial Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice.Mar 31, 2020

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Pubmed Data : Food Funct. 2022 Mar 7 ;13(5):2865-2883. Epub 2022 Mar 7. PMID: 35179534

Article Published Date : Mar 06, 2022

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Anxiety, Colitis, Depression

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents, Antioxidants, Gastrointestinal Agents

Additional Keywords : Gut-brain Axis

[+]

Sesamol ameliorates diet-induced obesity in C57BL/6J mice.Dec 23, 2016

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Pubmed Data : Mol Nutr Food Res. 2016 Dec 24. Epub 2016 Dec 24. PMID: 28012248

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Pubmed Data : Free Radic Res. 2015 ;49(11):1344-61. Epub 2015 Aug 12. PMID: 26156438

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Radioprotective

[+]

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Pubmed Data : Cell Physiol Biochem. 2011 ;27(3-4):273-80. Epub 2011 Apr 1. PMID: 21471716

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Hypertension, Myocardial Infarction

Pharmacological Actions : Antioxidants, Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Sesamol attenuates lipopolysaccharide induced hypotension by regulating the circulating inflammatory response.Dec 31, 2014

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Pubmed Data : Shock. 2006 May ;25(5):528-32. PMID: 16680019

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Lipid Peroxidation, Liver Damage, Oxidative Stress

Pharmacological Actions : Hepatoprotective

[+]

Sesamol exerts ameliorative effects in the experimental model of epilepsy.Jan 31, 2014

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Pubmed Data : Eur J Pharmacol. 2011 Jun 1 ;659(2-3):177-86. Epub 2011 Apr 2. PMID: 21463622

Article Published Date : Jun 01, 2011

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Brain Damage, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Sesamol has protective effects on mucosal in Inflammatory bowel disease.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Tylenol

Adverse Pharmacological Actions : Hepatotoxic, Oxidant

[+]

Sesamol protects against aluminum oxide nanoparticles-induced hepatorenal toxicity.Apr 10, 2022

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Pubmed Data : Environ Toxicol. 2022 Apr 11. Epub 2022 Apr 11. PMID: 35403826

[+]

Sesamol reverses myofiber-type conversion in obese states.Feb 22, 2022

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Pubmed Data : J Agric Food Chem. 2022 Feb 23 ;70(7):2253-2264. Epub 2022 Feb 15. PMID: 35166533

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Pubmed Data : J Clin Biochem Nutr. 2014 Mar ;54(2):95-101. Epub 2014 Feb 19. PMID: 24688218

Article Published Date : Feb 28, 2014

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Colon Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Sesamol suppresses neuropathic pain associated with diabetes.Oct 01, 2010

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Pubmed Data : J Pain. 2010 Oct ;11(10):950-7. Epub 2010 Apr 24. PMID: 20418182

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Pubmed Data : Pharmacol Rep. 2013 ;65(3):658-65. PMID: 23950588

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

This preclinical data promised the potential to consider sesamol as a metabolic modulator of HFD-induced obesity.Dec 31, 2020

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Pubmed Data : Food Nutr Res. 2021 ;65. Epub 2021 May 10. PMID: 34262421

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Pubmed Data : Molecules. 2019 Oct 27 ;24(21). Epub 2019 Oct 27. PMID: 31717859

Article Published Date : Oct 26, 2019

Study Type : In Vitro Study

Additional Links

Substances : Sesamol

Diseases : Melanoma

Pharmacological Actions : Antiproliferative

Additional Keywords : Selective Cytotoxicity

[+]

Sesame seed extract has antimicrobial properties. Jan 01, 2007

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Pubmed Data : Afr J Tradit Complement Altern Med. 2007 ;4(4):427-33. Epub 2007 Jun 10. PMID: 20161911

Article Published Date : Jan 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Sesame Seeds, Sesamol

Diseases : Candida Infection , Staphylococcus aureus infection, Streptococcus pneumoniae infection

Pharmacological Actions : Antimicrobial

Additional Keywords : Science Confirms Tradition

[+]

Sesame seed oil does not contain significant quantities of sesamol. Sep 01, 1987

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Pubmed Data : Contact Dermatitis. 1987 Sep ;17(3):133-5. PMID: 3677654

Article Published Date : Sep 01, 1987

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesamol

[+]

Sesame seeds essential oil and sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response.Dec 31, 2017

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Pubmed Data : Biochem Biophys Res Commun. 2016 Jan 1 ;469(1):49-54. Epub 2015 Nov 23. PMID: 26616060

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Pubmed Data : J Pharm Pharmacol. 2013 Jul ;65(7):1083-93. Epub 2013 Apr 22. PMID: 23738736

Article Published Date : Jun 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : Sesamol

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemoprotective Agents

Additional Keywords : Drug: Doxorubicin

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View the Evidence: 122 Abstracts with Sesamol Research

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Sesamol attenuates renal inflammation and arrests reactive-oxygen-species-mediated IL-1β secretion.Dec 13, 2022

ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders.Jun 04, 2019

Both free and encapsulated sesamol demonstrated inhibition of tumor progression by inducing skin cell apoptosis via bcl-2/bax mediated pathway.Aug 18, 2016

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.Dec 31, 2021

Elevated levels of cholesterol and triacylglycerol were significantly reversed by the sesamol.May 31, 2013

In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy.Aug 31, 2021

Neuroprotective effect of sesamol against aluminum nanoparticle-induced toxicity.May 25, 2021

Neuroprotective effects of some nutraceuticals against manganese-induced parkinson's disease.Dec 13, 2022

Oral supplementation of sesamol and sesamin beneficially modulated the inflammatory and oxidative stress markers.Feb 28, 2017

Preventive effects of sesamol on deep-frying oil-induced liver metabolism disorders.Feb 18, 2022

Protective effects of sesamol against liver oxidative stress and inflammation in high-fat diet-induced hepatic steatosis.Dec 14, 2021

Sesamin may prevent the development of atherosclerosis and inflammatory responsesSep 01, 2010

Sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice.Mar 31, 2020

Sesamol alleviates chronic intermittent hypoxia-induced cognitive deficits via inhibiting oxidative stress and inflammation in rats.Jan 12, 2021

Sesamol alleviates obesity-related hepatic steatosis via activating hepatic PKA pathway.Jan 25, 2020

Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis.Mar 06, 2022

Sesamol ameliorates diet-induced obesity in C57BL/6J mice.Dec 23, 2016

Sesamol ameliorates high-fat and high-fructose induced cognitive defects.Jan 18, 2017

Sesamol ameliorates renal injury-mediated atherosclerosis.Sep 23, 2021

Sesamol as a single prophylactic dose protects hematopoietic and gastrointestinal systems against γ-radiation-induced injury in mice.Dec 31, 2014

Sesamol attenuates aeuroinflammation by regulating the AMPK/SIRT1/NF- κB signaling pathway after spinal cord injury.Dec 31, 2021

Sesamol attenuates amyloid peptide accumulation and cognitive deficits.Nov 02, 2021

Sesamol attenuates diabetes-associated cognitive decline in rats. Mar 01, 2008

Sesamol attenuates diclofenac-induced acute gastric mucosal injury.Oct 01, 2008

Sesamol attenuates experimentally induced Huntington-like changes in an animal model. Jan 01, 2009

Sesamol attenuates experimentally induced myocardial infarction. Jan 01, 2011

Sesamol attenuates lipopolysaccharide induced hypotension by regulating the circulating inflammatory response.Dec 31, 2014

Sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome.Jun 17, 2011

Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats.Mar 31, 2012

Sesamol attenuates scopolamine-induced cholinergic disorders, neuroinflammation, and cognitive deficits.Oct 25, 2022

Sesamol attenuates the renoinflammatory cascade in experimental model of diabetic nephropathy. Jul 22, 2009

sesamol could be a potential neuroprotective agent during aging process due to its beneficial effects on liver-brain axis.Nov 13, 2018

Sesamol delays mortality and attenuates liver injury. May 01, 2006

Sesamol exerts ameliorative effects in the experimental model of epilepsy.Jan 31, 2014

Sesamol exhibits anti-depressant properties.Apr 01, 2011

Sesamol has been shown to protective effect against heavy metals caused cell damage.May 21, 2021

Sesamol has neuroprotective properties. Jun 01, 2011

Sesamol has protective effects on mucosal in Inflammatory bowel disease.Dec 31, 2013

Sesamol has radioprotective properties. Sep 01, 2009

Sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy.Dec 31, 2012

Sesamol has strong potential to protect hematopoietic system by lowering radiation induced DNA damages.Aug 01, 2017

Sesamol has therapeutic value in ovariectomy-induced pathophysiological changes.Sep 26, 2012

Sesamol has wound healing properties.Jan 27, 2011

Sesamol improves blood-brain-barrier function in diabetic rats. Jul 01, 2009

Sesamol improves bone mass in ovary intact growing and adult rats but accelerates bone deterioration in the ovariectomized rats.Aug 31, 2023

Sesamol induced functional improvements during 5 days after middle cerebral artery occlusion.May 31, 2015

Sesamol induced mitochondrial protection in LPS-treated cells by a mechanism involving heme oxigenase-1.Dec 24, 2018

Sesamol inhibits proliferation, migration and invasion of triple negative breast cancer.Nov 30, 2022

Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice.Dec 31, 2018

Sesamol mitigated Lipopolysaccharide induced amyloidogenesis and memory impairment.Nov 14, 2016

Sesamol promotes browning of white adipocytes through liver-adipose crosstalk signal of hepatic fibroblast growth factor 21.Apr 30, 2023

Sesamol protects against acetaminophen-induced injury in animals.Jul 01, 2009

Sesamol protects against aluminum oxide nanoparticles-induced hepatorenal toxicity.Apr 10, 2022

Sesamol protects against chemically-induced acute kidney injury in mice. Aug 01, 2008

Sesamol protects against chemically-induced liver damage in rats. Nov 01, 1994

Sesamol protects against chemically-induced oxidative renal injury in rats. Apr 01, 2009

Sesamol protects against cognitive dysfunction and altered glutathione redox balance. Jul 01, 2010

Sesamol protects against liver fibrosis.Jul 31, 2022

Sesamol protects against myocardial infarction. Jan 01, 2010

Sesamol protects against radiation-induced cytotoxicity in mice. Dec 10, 2006

Sesamol protects testis from ischemia-reperfusion injury.Dec 31, 2019

Sesamol protects the function and structure of rat ovaries against side effects of cyclophosphamide.Jun 30, 2022

Sesamol reduces pulmonary inflammatory response and lung injury in endotoxemic rats.Jul 01, 2010

Sesamol reduces total oxidant status, malondialdehyde levels and inhibits cataract formation.Nov 30, 2017

Sesamol reverses myofiber-type conversion in obese states.Feb 22, 2022

Sesamol supplementation attenuates DSS-induced colitis.Sep 29, 2020

Sesamol supplementation may serve as potent adjuvant in the treatment of focal cerebral ischemia-reperfusion injury.Jun 30, 2017

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

Sesamol suppresses neuropathic pain associated with diabetes.Oct 01, 2010

Sesamol upregulates death receptors and acts as a chemosensitizer in solid ehrlich carcinoma model.Jan 12, 2021

Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats.Mar 31, 2015

Sesamol-loaded PLGA nanosuspension for accelerating wound healing in diabetic foot ulcer in rats.Dec 31, 2019

Sesamol

View the Evidence:
122 Abstracts with Sesamol Research