Shiitake Mushroom

Name	AC	CK
Cancers: All	4	14
Inflammation	2	11
C-Reactive Protein	1	10
Quality of Life: Poor	1	10
Breast Cancer	5	6
Colon Cancer	3	5
Chemically-Induced Liver Damage	2	4
Hypercholesterolemia	2	4
Triglycerides: Elevated	2	4
HIV Infections	3	3
Leukemia	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging	1	2
Animal Cancers	1	2
Arteriosclerosis	1	2
Arthritis	1	2
Atopic Dermatitis	1	2
Breast Cancer: Triple Negative	1	2
Diabetes Mellitus: Type 1	1	2
Hepatitis C	1	2
High Fat Diet	1	2
Hyperlipidemia	1	2
Influenza	1	2
Klebsiella Infections	1	2
Liver Cancer	1	2
Liver Disease	1	2
Lung Cancer	2	2
Osteoporosis	1	2
Sepsis	1	2
Skin Cancer	1	2
Tumors	1	2
Ulcerative Colitis	1	2
Atherosclerosis	1	1
Bacterial Infections and Mycoses	1	1
Cervical Cancer	1	1
Clotting	1	1
DNA damage	1	1
Diabetes: Oxidative Stress	1	1
Fungal Infection	1	1
Gastric Cancer	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Immune Disorders: Low Immune Function	1	1
Kidney Cancer	1	1
Laryngeal Cancer	1	1
Larynx Neoplasms	1	1
Lipopolysaccharide-Induced Toxicity	1	1
Lymphoma	1	1
Multiple Myeloma	1	1
Osteosarcoma	1	1

Name	AC	CK
Immunomodulatory	11	25
Anti-Inflammatory Agents	6	19
Immunostimulatory	4	16
Apoptotic	7	11
Interferon-gamma (IFN-gamma) inducer	1	10
Interleukin-10 upregulation	1	10
Interleukin-4 upregulation	1	10
Antiproliferative	7	9
Antioxidants	4	6
Hepatoprotective	3	6
Hypolipidemic	3	6
Anticholesteremic Agents	2	4
Cell cycle arrest	3	4
Interleukin-6 Downregulation	2	4
Anti-Bacterial Agents	2	3
Antifungal Agents	3	3
Angiogenesis Inhibitors	1	2
Anti-HIV Agents	2	2
Anti-atherogenic	1	2
Anti-metastatic	1	2
Bax/Bcl2 ratio: Increase	1	2
Bcl-2 protein down-regulation	1	2
Caspase-3 Activation	1	2
Chemosensitizer	1	2
Chemotherapeutic	1	2
Cyclooxygenase 2 Inhibitors	1	2
Cytotoxic	2	2
Hypoglycemic Agents	1	2
Interleukin-1 beta downregulation	1	2
NF-kappaB Inhibitor	1	2
Nitric Oxide Inhibitor	1	2
Osteogenic	1	2
Osteoprotective	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Antimicrobial	1	1
Autophagy Up-regulation	1	1
Cardioprotective	1	1
Genoprotective	1	1
Pancreato Protective Agents	1	1
Platelet Aggregation Inhibitors	1	1

[+]

AGM possibly improves insulin sensitivity and β-cell function and reduces liver damage and inflammation in prediabetic adults.Jul 04, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Foods. 2021 Jul 5 ;10(7). Epub 2021 Jul 5. PMID: 34359426

Article Published Date : Jul 04, 2021

Study Type : Human Study

Additional Links

Substances : Chokeberry, Ginseng, Nattokinase, Shiitake Mushroom

Diseases : Prediabetes

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

[+]

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

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Pubmed Data : J Am Coll Nutr. 2015 ;34(6):478-87. Epub 2015 Apr 11. PMID: 25866155

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Shiitake Mushroom

Diseases : C-Reactive Protein, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Immunostimulatory, Interleukin-10 upregulation, Interleukin-4 upregulation

[+]

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27888812

Article Published Date : Nov 20, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, NF-kappaB Inhibitor

Additional Keywords : Polysaccharides

[+]

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice. Mar 18, 2005

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Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684

Article Published Date : Mar 18, 2005

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Skin Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest

Additional Keywords : Antiproliferative, Selective Cytotoxicity

[+]

Diets containing shiitake mushroom reduce serum lipids and serum lipophilic antioxidant capacity in rats.Nov 30, 2016

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Pubmed Data : J Nutr. 2016 Dec ;146(12):2491-2496. Epub 2016 Oct 19. PMID: 27798348

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Hyperlipidemia, Triglycerides: Elevated

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

[+]

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes.Mar 06, 2022

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Pubmed Data : Food Funct. 2022 Mar 7 ;13(5):3036-3049. Epub 2022 Mar 7. PMID: 35199807

Article Published Date : Mar 06, 2022

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hypoglycemic Agents, Nrf2 activation

Additional Keywords : Polysaccharides

[+]

Immunomodulating glucans from Maitake and Shiitake mushrooms strongly stimulated both the cellular and humoral branch of immune reactions.Jan 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Transl Med. 2014 Feb ;2(2):14. PMID: 25332990

Article Published Date : Jan 31, 2014

Study Type : Animal Study

Additional Links

Substances : Maitake Mushroom, Shiitake Mushroom

Pharmacological Actions : Immunostimulatory

Additional Keywords : Plant Extracts

[+]

L. edodes extract may have therapeutic potential in the treatment of atopic dermatitis attributable to its immunomodulatory effects.Jul 28, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2016 Jul 29 ;21(8). Epub 2016 Jul 29. PMID: 27483228

Article Published Date : Jul 28, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Atopic Dermatitis

Pharmacological Actions : Immunomodulatory

[+]

Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans.Mar 30, 2022

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Pubmed Data : Int J Biol Macromol. 2022 Mar 31 ;202:286-295. Epub 2022 Jan 15. PMID: 35041882

Article Published Date : Mar 30, 2022

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Polysaccharides

[+]

Lentinan from shiitake mushrooms (Lentinus edodes) inhibits of human colon cancer cells. Oct 01, 2002

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2002 Oct;8(5):581-9. PMID: 12470439

Article Published Date : Oct 01, 2002

Study Type : Animal Study

Additional Links

Substances : Beta-glucan, Lentinan, Shiitake Mushroom

Diseases : Colon Cancer

Additional Keywords : Antineoplastic Agents

[+]

Lentinan has a significantly synergistic anti-tumor effect with oxaliplatin against HepG2 cells in vitro and in H22 tumor-bearing mice.Jul 27, 2016

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Pubmed Data : Cancer Lett. 2016 Jul 28 ;377(2):117-25. Epub 2016 Apr 26. PMID: 27130669

Article Published Date : Jul 27, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Liver Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin, Polysaccharides

[+]

Mixed polysaccharides derived from Shiitake mushroom, Poriacocos, Ginger, and Tangerine peel enhanced protective immune responses in mice induced by inactivated influenza vaccine.Mar 11, 2020

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Pubmed Data : Biomed Pharmacother. 2020 Mar 12 ;126:110049. Epub 2020 Mar 12. PMID: 32172063

Article Published Date : Mar 11, 2020

Study Type : Animal Study

Additional Links

Substances : Fruit Peel, Ginger, Medicinal Mushrooms, Shiitake Mushroom

Diseases : Influenza

Pharmacological Actions : Immunomodulatory, Immunostimulatory

[+]

Mushroom extracts decrease bone resorption and improve bone formation.Dec 31, 2015

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Pubmed Data : Int J Med Mushrooms. 2016 ;18(7):559-69. PMID: 27649725

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Maitake Mushroom, Oyster Mushroom, Shiitake Mushroom

Diseases : Osteoporosis

Pharmacological Actions : Osteogenic, Osteoprotective

Additional Keywords : Plant Extracts

[+]

Novel medicinal mushroom blend as a promising supplement in integrative oncology.May 13, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 May 14 ;21(10). Epub 2020 May 14. PMID: 32423132

Article Published Date : May 13, 2020

Study Type : Animal Study

Additional Links

Substances : Agaricus Blazei, Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation

[+]

Purified β-glucans from the Shiitake mushroom ameliorates antibiotic-resistant Klebsiella pneumoniae-induced pulmonary sepsis.Sep 30, 2020

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Pubmed Data : Lett Appl Microbiol. 2020 Oct ;71(4):405-412. Epub 2020 Aug 14. PMID: 32706908

Article Published Date : Sep 30, 2020

Study Type : Animal Study

Additional Links

Substances : Beta-glucan, Shiitake Mushroom

Diseases : Klebsiella Infections, Sepsis

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Plant Extracts

[+]

Shiitake and medium-chain triglyceride-rich plant oil work together to reduce lipid profiles and lecithin-cholesterol acyltransferase activity in serum.Apr 26, 2018

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Pubmed Data : J Diet Suppl. 2018 Apr 27:1-12. Epub 2018 Apr 27. PMID: 29701491

Article Published Date : Apr 26, 2018

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : High Fat Diet

Pharmacological Actions : Hypolipidemic

Additional Keywords : Plant Oils

[+]

Shiitake contains compounds with hypoglycemic activity in a rat model of type 1 diabetes. May 01, 2002

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Pubmed Data : Biosci Biotechnol Biochem. 2002 May;66(5):937-42. PMID: 12092843

Article Published Date : May 01, 2002

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Diabetes Mellitus: Type 1, Triglycerides: Elevated

Pharmacological Actions : Hypoglycemic Agents

[+]

Shiitake extract inhibits cancer cell proliferation possibly through a reduction in Natural Killer cell cytotoxicity. Oct 01, 2003

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Pubmed Data : Actas Urol Esp. 2003 Oct;27(9):732-4. PMID: 19059811

Article Published Date : Oct 01, 2003

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Cancers: All

Additional Keywords : Antineoplastic Agents

[+]

Shiitake extract significantly inhibits atherosclerosis development in a rabbit model. Jan 01, 2002

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Pubmed Data : J Atheroscler Thromb. 2002;9(3):149-56. PMID: 12226557

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Arteriosclerosis

Pharmacological Actions : Anti-atherogenic

[+]

Shiitake has antioxidant and liver-protective effects against paracetamol-induced liver damage.Jun 01, 2010

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Pubmed Data : Molecules. 2010 Jun;15(6):4478-89. Epub 2010 Jun 23. PMID: 20657455

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

[+]

Shiitake may serve as a potent therapeutic agent against inflammatory bowel disease.Mar 31, 2022

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Pubmed Data : Arq Gastroenterol. 2022 Apr-Jun;59(2):288-295. PMID: 35830043

Article Published Date : Mar 31, 2022

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Polysaccharides

[+]

Shiitake mushroom derived polysaccharide can partly reverse the age-altered composition of gut microbiota.Jul 31, 2015

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Pubmed Data : Food Funct. 2015 Aug ;6(8):2653-63. Epub 2015 Jul 2. PMID: 26135107

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Aging

Pharmacological Actions : Immunomodulatory

Additional Keywords : Microbiota, Plant Extracts

[+]

Shiitake polysaccharide enhanced systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice.May 31, 2015

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Pubmed Data : Food Funct. 2015 Jun ;6(6):2068-80. PMID: 26034783

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Pharmacological Actions : Immunomodulatory, Immunostimulatory

Additional Keywords : Gene Expression Regulation, Microbiota

[+]

Shiitake supplementation modulated the transcriptional profile of some genes involved in the cholesterol metabolism similarly to simvastatin.Mar 08, 2016

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Pubmed Data : J Agric Food Chem. 2016 Mar 9 ;64(9):1910-20. Epub 2016 Mar 1. PMID: 26877235

Article Published Date : Mar 08, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Hypercholesterolemia

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation, Natural Substances Versus Drugs

[+]

The results show the immunomodulatory, hepatoprotective, and antioxidant activities of L. edodes supplementation in hypercholesterolemia.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Int J Med Mushrooms. 2017 ;19(11):981-990. PMID: 29345560

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Hypercholesterolemia

Pharmacological Actions : Antioxidants, Hepatoprotective, Immunomodulatory

[+]

The results suggest that the elm tree bark bioprocessed with mycelia of shiitake mushrooms has the potential to prevent and treat allergic asthma.Feb 02, 2016

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Pubmed Data : J Agric Food Chem. 2016 Feb 3 ;64(4):773-84. Epub 2016 Jan 25. PMID: 26807923

Article Published Date : Feb 02, 2016

Study Type : Animal Study

Additional Links

Substances : Elm tree, Shiitake Mushroom

Diseases : Asthma

Pharmacological Actions : Anti-Asthmatic Agents, Prophylactic Agents

Additional Keywords : Plant Extracts

[+]

Vitamin D-enriched Shiitake mushroom exerts a synergistic anti-inflammatory effect in an immune-mediated hepatitis model.Mar 29, 2016

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Pubmed Data : J Med Food. 2016 Mar 30. Epub 2016 Mar 30. PMID: 27027234

Article Published Date : Mar 29, 2016

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom , Vitamin D

Diseases : Chemically-Induced Liver Damage, Hepatitis C, Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance Synergy, Plant Extracts

Problem Substances : Concanavalin A

[+]

White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis mice.Jan 01, 2011

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Pubmed Data : J Nutr. 2011 Jan;141(1):131-6. Epub 2010 Nov 24. PMID: 21106932

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom , White Button Mushroom

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

β-glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers.Oct 16, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Oct 17 ;8(49):86693-86709. Epub 2017 Sep 30. PMID: 29156828

Article Published Date : Oct 16, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Antiproliferative, Apoptotic, Breast Cancer, Shiitake Mushroom

[+]

β-glucans from Lentinus edodes could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.Nov 08, 2016

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Pubmed Data : Food Funct. 2016 Nov 9 ;7(11):4614-4627. PMID: 27747357

Article Published Date : Nov 08, 2016

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

β-glucans from Lentinus edodes inhibited angiogenesis by suppressing VEGF expression, leading to slow progression of tumors.Jun 28, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Jun 29 ;6:28802. Epub 2016 Jun 29. PMID: 27353254

Article Published Date : Jun 28, 2016

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Animal Cancers, Tumors

Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Bcl-2 protein down-regulation

[+]

A derivative of Lentinula edodes C 91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G 1 phase in breast cancer cells.Nov 30, 2020

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Pubmed Data : Appl Microbiol Biotechnol. 2020 Dec ;104(23):10165-10179. Epub 2020 Oct 12. PMID: 33044599

Article Published Date : Nov 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest

[+]

A proprietary shitake/rice bran extract, encourages human leukemic cells to programmed cell death.Nov 10, 2003

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Pubmed Data : Cancer Lett. 2003 Nov 10;201(1):41-9. PMID: 14580685

Article Published Date : Nov 10, 2003

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3), Shiitake Mushroom

Diseases : Leukemia

[+]

A shiitake/rice bran combination known as MGN-3 has potent anti-HIV activity. Feb 04, 1998

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Pubmed Data : Biochem Biophys Res Commun. 1998 Feb 4;243(1):25-9. PMID: 9473473

Article Published Date : Feb 04, 1998

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3), Rice Bran, Shiitake Mushroom

Diseases : HIV Infections

Pharmacological Actions : Anti-HIV Agents

[+]

Antigenotoxic and antioxidant potential of medicinal mushrooms against DNA damage induced by free radicals-an in vitro study.Aug 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mutat Res. 2019 Sep ;845:403078. Epub 2019 Aug 1. PMID: 31561902

Article Published Date : Aug 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Agaricus Blazei, Cordyceps sinensis, Medicinal Mushrooms, Reishi Mushroom, Shiitake Mushroom , Turkey Tail Mushroom

Diseases : DNA damage, Hydrogen Peroxide Induced Toxicity

Pharmacological Actions : Genoprotective

[+]

Antimicrobial, cytotoxic, anti-inflammatory, and antioxidant activity of culinary processed Shiitake medicinal mushroom.Dec 31, 2017

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Pubmed Data : Int J Med Mushrooms. 2018 ;20(2):165-175. PMID: 29773008

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Antioxidants, Cytotoxic

[+]

Extracts from medicinal basidiomycetes mushrooms had anti-tumor activity against cancer cell lines. Dec 31, 2015

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Pubmed Data : Int J Med Mushrooms. 2016 ;18(11):955-964. PMID: 28008808

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom

Diseases : Kidney Cancer, Laryngeal Cancer, Lung Cancer

Pharmacological Actions : Cytotoxic, Immunomodulatory

[+]

Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts.Oct 18, 2020

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Pubmed Data : Food Chem. 2020 Oct 19:128344. Epub 2020 Oct 19. PMID: 33268175

Article Published Date : Oct 18, 2020

Study Type : In Vitro Study

Additional Links

Substances : Kombucha Tea, Shiitake Mushroom , Turkey Tail Mushroom

Pharmacological Actions : Immunomodulatory

Additional Keywords : Polysaccharides

[+]

In vitro anti SARS-CoV-2 activity and docking analysis of Pleurotus ostreatus, Lentinula edodes and Agaricus bisporus edible mushrooms.Dec 31, 2021

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Pubmed Data : Infect Drug Resist. 2022 ;15:3459-3475. Epub 2022 Jul 2. PMID: 35813084

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Oyster Mushroom, Shiitake Mushroom , White Button Mushroom

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

L. edodes possesses anti-atherosclerotic bio-functionality that can be applied as functional food-based therapeutics against cardiovascular diseases.Nov 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Saudi J Biol Sci. 2018 Dec ;25(8):1515-1523. Epub 2016 Feb 8. PMID: 30581314

Article Published Date : Nov 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Atherosclerosis

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Lentin, a beta-glucan rich protein from shitake mushroom, demonstrates inhibitory effects on activity of HIV-1 reverse transcriptase and proliferation of leukemia cells.Dec 10, 2009

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Pubmed Data : J Med Chem. 2009 Dec 10;52(23):7887-91. PMID: 19526990

Article Published Date : Dec 10, 2009

Study Type : In Vitro Study

Additional Links

Substances : Beta-glucan, Shiitake Mushroom

Diseases : HIV Infections, Leukemia

Pharmacological Actions : Anti-HIV Agents, Antifungal Agents

[+]

Lentin, a novel and potent antifungal protein from shitake mushroom exhibits inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells.Nov 14, 2003

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Pubmed Data : Life Sci. 2003 Nov 14;73(26):3363-74. PMID: 14572878

Article Published Date : Nov 14, 2003

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Fungal Infection, HIV Infections, Leukemia

Pharmacological Actions : Antifungal Agents

Additional Keywords : Plant Extracts

[+]

Lentinan may be a potential pharmacological agent for preventing pancreatic β‐cell damage caused by oxidative stress.Sep 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cell Mol Med. 2016 Oct ;20(10):1803-12. Epub 2016 Jul 22. PMID: 27444655

Article Published Date : Sep 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Diabetes: Oxidative Stress

Pharmacological Actions : Pancreato Protective Agents

Additional Keywords : Dose Response

Problem Substances : Streptozotocin

[+]

Lentinan up-regulates microRNA-340 to promote apoptosis and autophagy of human osteosarcoma cells.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Clin Exp Pathol. 2018 ;11(8):3876-3883. Epub 2018 Aug 1. PMID: 31949775

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Osteosarcoma

Pharmacological Actions : Apoptotic, Autophagy Up-regulation, MicroRNA modulator

Additional Keywords : Polysaccharides

[+]

Polysaccharides from Lentinus edodes exhibited inhibition of cell proliferation on HCT-116 and HeLa cells in vitro.Nov 30, 2016

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Pubmed Data : Int J Biol Macromol. 2016 Dec ;93(Pt A):136-144. Epub 2016 May 28. PMID: 27246376

Article Published Date : Nov 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Cervical Cancer, Colon Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Polysaccharides

[+]

Shiitake aqueous extracts have demonstrated direct inhibition of the proliferation of human breast cancer cells in vitro and immunostimulatory properties. Jun 01, 2008

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Pubmed Data : Phytomedicine. 2008 Jun;15(6-7):512-9. Epub 2008 Feb 1. PMID: 18242970

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Immunomodulatory

[+]

Shiitake exhibits anti-platelet activity. Jan 01, 2004

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Pubmed Data : Biofactors. 2004;22(1-4):177-9. PMID: 15630278

Article Published Date : Jan 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Clotting

Pharmacological Actions : Platelet Aggregation Inhibitors

Additional Keywords : Plant Extracts

[+]

Shiitake inhibits the growth of breast and myeloma tumor cells. Mar 01, 2006

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Pubmed Data : J Altern Complement Med. 2006 Mar;12(2):125-32. PMID: 16566671

Article Published Date : Mar 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Breast Cancer, Cancers: All, Multiple Myeloma

Pharmacological Actions : Apoptotic, Cell cycle arrest

Additional Keywords : Selective Cytotoxicity

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Shiitake polysaccharide fractions exhibited antiproliferative activity against the tested human tumor cell lines in a concentration-dependent manner.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Int J Med Mushrooms. 2017 ;19(5):395-403. PMID: 28845769

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Breast Cancer, Gastric Cancer, Lung Cancer, Lymphoma, Osteosarcoma

Pharmacological Actions : Antiproliferative

Additional Keywords : Dose Response, Polysaccharides

[+]

Shiitake potentiates intestinal immunity. Apr 01, 2007

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Pubmed Data : Biomed Res. 2007 Apr;28(2):71-7. PMID: 17510491

Article Published Date : Apr 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Immune Disorders: Low Immune Function

Pharmacological Actions : Immunomodulatory

Additional Keywords : Plant Extracts

[+]

Shitake has significant antibacterial and antifungal activity. Feb 01, 2009

Click here to read the entire abstract

Pubmed Data : Complement Ther Clin Pract. 2009 Feb;15(1):5-7. Epub 2008 Dec 2. PMID: 19161947

Article Published Date : Feb 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Bacterial Infections and Mycoses

Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents

[+]

Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2019 ;14(11):e0224740. Epub 2019 Nov 7. PMID: 31697749

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Immunomodulatory

Additional Keywords : Natural Substance Synergy

[+]

These findings highlight the mushroom's pharmacological potential in cancer treatment.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Int J Med Mushrooms. 2018 ;20(1):31-46. PMID: 29604911

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Larynx Neoplasms

Pharmacological Actions : Antiproliferative , Apoptotic

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View the Evidence: 54 Abstracts with Shiitake Mushroom Research

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A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

AGM possibly improves insulin sensitivity and β-cell function and reduces liver damage and inflammation in prediabetic adults.Jul 04, 2021

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice. Mar 18, 2005

Diets containing shiitake mushroom reduce serum lipids and serum lipophilic antioxidant capacity in rats.Nov 30, 2016

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes.Mar 06, 2022

Immunomodulating glucans from Maitake and Shiitake mushrooms strongly stimulated both the cellular and humoral branch of immune reactions.Jan 31, 2014

L. edodes extract may have therapeutic potential in the treatment of atopic dermatitis attributable to its immunomodulatory effects.Jul 28, 2016

Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans.Mar 30, 2022

Lentinan from shiitake mushrooms (Lentinus edodes) inhibits of human colon cancer cells. Oct 01, 2002

Lentinan has a significantly synergistic anti-tumor effect with oxaliplatin against HepG2 cells in vitro and in H22 tumor-bearing mice.Jul 27, 2016

Mixed polysaccharides derived from Shiitake mushroom, Poriacocos, Ginger, and Tangerine peel enhanced protective immune responses in mice induced by inactivated influenza vaccine.Mar 11, 2020

Mushroom extracts decrease bone resorption and improve bone formation.Dec 31, 2015

Novel medicinal mushroom blend as a promising supplement in integrative oncology.May 13, 2020

Purified β-glucans from the Shiitake mushroom ameliorates antibiotic-resistant Klebsiella pneumoniae-induced pulmonary sepsis.Sep 30, 2020

Shiitake and medium-chain triglyceride-rich plant oil work together to reduce lipid profiles and lecithin-cholesterol acyltransferase activity in serum.Apr 26, 2018

Shiitake contains compounds with hypoglycemic activity in a rat model of type 1 diabetes. May 01, 2002

Shiitake extract inhibits cancer cell proliferation possibly through a reduction in Natural Killer cell cytotoxicity. Oct 01, 2003

Shiitake extract significantly inhibits atherosclerosis development in a rabbit model. Jan 01, 2002

Shiitake has antioxidant and liver-protective effects against paracetamol-induced liver damage.Jun 01, 2010

Shiitake may serve as a potent therapeutic agent against inflammatory bowel disease.Mar 31, 2022

Shiitake mushroom derived polysaccharide can partly reverse the age-altered composition of gut microbiota.Jul 31, 2015

Shiitake polysaccharide enhanced systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice.May 31, 2015

Shiitake supplementation modulated the transcriptional profile of some genes involved in the cholesterol metabolism similarly to simvastatin.Mar 08, 2016

The results show the immunomodulatory, hepatoprotective, and antioxidant activities of L. edodes supplementation in hypercholesterolemia.Dec 31, 2016

The results suggest that the elm tree bark bioprocessed with mycelia of shiitake mushrooms has the potential to prevent and treat allergic asthma.Feb 02, 2016

Vitamin D-enriched Shiitake mushroom exerts a synergistic anti-inflammatory effect in an immune-mediated hepatitis model.Mar 29, 2016

White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis mice.Jan 01, 2011

β-glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers.Oct 16, 2017

β-glucans from Lentinus edodes could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.Nov 08, 2016

β-glucans from Lentinus edodes inhibited angiogenesis by suppressing VEGF expression, leading to slow progression of tumors.Jun 28, 2016

A derivative of Lentinula edodes C 91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G 1 phase in breast cancer cells.Nov 30, 2020

A proprietary shitake/rice bran extract, encourages human leukemic cells to programmed cell death.Nov 10, 2003

A shiitake/rice bran combination known as MGN-3 has potent anti-HIV activity. Feb 04, 1998

Antigenotoxic and antioxidant potential of medicinal mushrooms against DNA damage induced by free radicals-an in vitro study.Aug 31, 2019

Antimicrobial, cytotoxic, anti-inflammatory, and antioxidant activity of culinary processed Shiitake medicinal mushroom.Dec 31, 2017

Extracts from medicinal basidiomycetes mushrooms had anti-tumor activity against cancer cell lines. Dec 31, 2015

Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts.Oct 18, 2020

In vitro anti SARS-CoV-2 activity and docking analysis of Pleurotus ostreatus, Lentinula edodes and Agaricus bisporus edible mushrooms.Dec 31, 2021

L. edodes possesses anti-atherosclerotic bio-functionality that can be applied as functional food-based therapeutics against cardiovascular diseases.Nov 30, 2018

Lentin, a beta-glucan rich protein from shitake mushroom, demonstrates inhibitory effects on activity of HIV-1 reverse transcriptase and proliferation of leukemia cells.Dec 10, 2009

Lentin, a novel and potent antifungal protein from shitake mushroom exhibits inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells.Nov 14, 2003

Lentinan may be a potential pharmacological agent for preventing pancreatic β‐cell damage caused by oxidative stress.Sep 30, 2016

Lentinan up-regulates microRNA-340 to promote apoptosis and autophagy of human osteosarcoma cells.Dec 31, 2017

Polysaccharides from Lentinus edodes exhibited inhibition of cell proliferation on HCT-116 and HeLa cells in vitro.Nov 30, 2016

Shiitake aqueous extracts have demonstrated direct inhibition of the proliferation of human breast cancer cells in vitro and immunostimulatory properties. Jun 01, 2008

Shiitake exhibits anti-platelet activity. Jan 01, 2004

Shiitake inhibits the growth of breast and myeloma tumor cells. Mar 01, 2006

Shiitake polysaccharide fractions exhibited antiproliferative activity against the tested human tumor cell lines in a concentration-dependent manner.Dec 31, 2016

Shiitake potentiates intestinal immunity. Apr 01, 2007

Shitake has significant antibacterial and antifungal activity. Feb 01, 2009

Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake.Dec 31, 2018

These findings highlight the mushroom's pharmacological potential in cancer treatment.Dec 31, 2017

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View the Evidence:
54 Abstracts with Shiitake Mushroom Research