Shiitake Mushroom

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62 Diseases Researched for Shiitake Mushroom
NameACCKFocus
Breast Cancer818Locked
Cancers: All414Locked
Inflammation211Locked
C-Reactive Protein110Locked
Chemotherapy110Locked
Pancreatic Cancer110Locked
Prediabetes110Locked
Quality of Life: Poor110Locked
Taste Disorders110Locked
Colon Cancer35Locked
Aging24Locked
Chemically-Induced Liver Damage24Locked
Hypercholesterolemia24Locked
Triglycerides: Elevated24Locked
HIV Infections33Locked
Leukemia33Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Animal Cancers12Locked
Arteriosclerosis12Locked
Arthritis12Locked
Asthma12Locked
Atopic Dermatitis12Locked
Breast Cancer: Triple Negative 12Locked
Colitis12Locked
Diabetes Mellitus: Type 112Locked
Diabetes Mellitus: Type 212Locked
Gastric Cancer22Locked
Hepatitis C12Locked
High Fat Diet12Locked
Hyperlipidemia12Locked
Influenza12Locked
Klebsiella Infections12Locked
Liver Cancer12Locked
Liver Disease12Locked
Liver Injury: Ischemia/reperfusion 12Locked
Lung Cancer22Locked
Osteoporosis12Locked
Osteosarcoma22Locked
Oxidative Stress12Locked
Sepsis12Locked
Skin Cancer12Locked
Tumors12Locked
Ulcerative Colitis12Locked
Advanced Glycation End products (AGE)11Locked
Atherosclerosis11Locked
Bacterial Infections and Mycoses11Locked
Cervical Cancer11Locked
Clotting11Locked
Colorectal Cancer11Locked
Coronavirus Infection11Locked
DNA damage11Locked
Diabetes: Oxidative Stress11Locked
Fungal Infection11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Immune Disorders: Low Immune Function11Locked
Kidney Cancer11Locked
Laryngeal Cancer11Locked
Larynx Neoplasms11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Lymphoma11Locked
Multiple Myeloma11Locked
Obesity11Locked
50 Pharmacological Actions Researched for Shiitake Mushroom
NameACCKFocus
Immunomodulatory1336Locked
Anti-Inflammatory Agents1034Locked
Hepatoprotective518Locked
Immunostimulatory416Locked
Apoptotic812Locked
Chemotherapeutic212Locked
Chemoprotective Agents211Locked
Antioxidants610Locked
Interferon-gamma (IFN-gamma) inducer110Locked
Interleukin-10 upregulation110Locked
Interleukin-4 upregulation110Locked
Antiproliferative 79Locked
Hypolipidemic36Locked
Interleukin-6 Downregulation36Locked
Anticholesteremic Agents24Locked
Cell cycle arrest34Locked
Hypoglycemic Agents24Locked
Interleukin-1 beta downregulation24Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor24Locked
Anti-Bacterial Agents23Locked
Anti-metastatic23Locked
Antifungal Agents33Locked
Angiogenesis Inhibitors12Locked
Anti-Asthmatic Agents12Locked
Anti-HIV Agents22Locked
Anti-atherogenic12Locked
Autophagy Up-regulation22Locked
Bax/Bcl2 ratio: Increase12Locked
Bcl-2 protein down-regulation12Locked
Caspase-3 Activation12Locked
Chemosensitizer12Locked
Cyclooxygenase 2 Inhibitors12Locked
Cytotoxic22Locked
Heme oxygenase-1 up-regulation12Locked
Interferon Gamma Reducer12Locked
NF-kappaB Inhibitor12Locked
Nitric Oxide Inhibitor12Locked
Nrf2 activation12Locked
Osteogenic12Locked
Osteoprotective 12Locked
Prophylactic Agents12Locked
Anti-Glycation Agents11Locked
Antimicrobial11Locked
Antineoplastic Agents11Locked
Antiviral Agents11Locked
Cardioprotective11Locked
Genoprotective11Locked
MicroRNA modulator11Locked
Pancreato Protective Agents11Locked
Platelet Aggregation Inhibitors11Locked
Related Topics

Shiitake Mushroom is a Sub of the following Topic

View the Evidence:
61 Abstracts with Shiitake Mushroom Research

[+]

A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

Pubmed Data : Altern Ther Health Med. 2016 Jul ;22(4):36-42. PMID: 27548491
Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Cancers: All, Quality of Life: Poor
Pharmacological Actions : Immunomodulatory, Interferon-gamma (IFN-gamma) inducer
[+]

AGM possibly improves insulin sensitivity and β-cell function and reduces liver damage and inflammation in prediabetic adults.Jul 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2021 Jul 5 ;10(7). Epub 2021 Jul 5. PMID: 34359426
Article Published Date : Jul 04, 2021
Study Type : Human Study
Additional Links
Substances : Chokeberry, Ginseng, Nattokinase, Shiitake Mushroom
Diseases : Prediabetes
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy.Dec 31, 2010

Pubmed Data : Am J Chin Med. 2011 ;39(3):451-9. PMID: 21598414
Article Published Date : Dec 31, 2010
Study Type : Human Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic, Immunomodulatory
[+]

Efficacy of Lentinula edodes mycelia extract on chemotherapy-related tasted disorders in pancreatic cancer patients.Dec 31, 2022

Pubmed Data : Nutr Cancer. 2023 ;75(1):236-246. Epub 2022 Aug 11. PMID: 35950537
Article Published Date : Dec 31, 2022
Study Type : Human Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Chemotherapy, Pancreatic Cancer, Taste Disorders
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Plant Extracts
[+]

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

Pubmed Data : J Am Coll Nutr. 2015 ;34(6):478-87. Epub 2015 Apr 11. PMID: 25866155
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Shiitake Mushroom
Diseases : C-Reactive Protein, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Immunostimulatory, Interleukin-10 upregulation, Interleukin-4 upregulation
[+]

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27888812
Article Published Date : Nov 20, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, NF-kappaB Inhibitor
Additional Keywords : Polysaccharides
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An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice. Mar 18, 2005

Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684
Article Published Date : Mar 18, 2005
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Skin Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
Additional Keywords : Antiproliferative, Selective Cytotoxicity
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Diets containing shiitake mushroom reduce serum lipids and serum lipophilic antioxidant capacity in rats.Nov 30, 2016

Pubmed Data : J Nutr. 2016 Dec ;146(12):2491-2496. Epub 2016 Oct 19. PMID: 27798348
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Hyperlipidemia, Triglycerides: Elevated
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
[+]

Hepatoprotection of a standardized extract of cultured Lentinula edodes mycelia against liver Injury induced by ischemia-reperfusion.Jan 13, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Jan 14 ;16(2). Epub 2024 Jan 14. PMID: 38257149
Article Published Date : Jan 13, 2024
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Liver Regeneration
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Hypoglycemic effect of a novel polysaccharide from Lentinus edodes.Mar 06, 2022

Pubmed Data : Food Funct. 2022 Mar 7 ;13(5):3036-3049. Epub 2022 Mar 7. PMID: 35199807
Article Published Date : Mar 06, 2022
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hypoglycemic Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Immunomodulating glucans from Maitake and Shiitake mushrooms strongly stimulated both the cellular and humoral branch of immune reactions.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2014 Feb ;2(2):14. PMID: 25332990
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom, Shiitake Mushroom
Pharmacological Actions : Immunostimulatory
Additional Keywords : Plant Extracts
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L. edodes extract may have therapeutic potential in the treatment of atopic dermatitis attributable to its immunomodulatory effects.Jul 28, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Jul 29 ;21(8). Epub 2016 Jul 29. PMID: 27483228
Article Published Date : Jul 28, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Atopic Dermatitis
Pharmacological Actions : Immunomodulatory
[+]

Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans.Mar 30, 2022

Pubmed Data : Int J Biol Macromol. 2022 Mar 31 ;202:286-295. Epub 2022 Jan 15. PMID: 35041882
Article Published Date : Mar 30, 2022
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Polysaccharides
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Lentinan from shiitake mushrooms (Lentinus edodes) inhibits of human colon cancer cells. Oct 01, 2002

Pubmed Data : J Altern Complement Med. 2002 Oct;8(5):581-9. PMID: 12470439
Article Published Date : Oct 01, 2002
Study Type : Animal Study
Additional Links
Substances : Beta-glucan, Lentinan, Shiitake Mushroom
Diseases : Colon Cancer
Additional Keywords : Antineoplastic Agents
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Lentinan has a significantly synergistic anti-tumor effect with oxaliplatin against HepG2 cells in vitro and in H22 tumor-bearing mice.Jul 27, 2016

Pubmed Data : Cancer Lett. 2016 Jul 28 ;377(2):117-25. Epub 2016 Apr 26. PMID: 27130669
Article Published Date : Jul 27, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin, Polysaccharides
[+]

Mixed polysaccharides derived from Shiitake mushroom, Poriacocos, Ginger, and Tangerine peel enhanced protective immune responses in mice induced by inactivated influenza vaccine.Mar 11, 2020

Pubmed Data : Biomed Pharmacother. 2020 Mar 12 ;126:110049. Epub 2020 Mar 12. PMID: 32172063
Article Published Date : Mar 11, 2020
Study Type : Animal Study
Additional Links
Substances : Fruit Peel, Ginger, Medicinal Mushrooms, Shiitake Mushroom
Diseases : Influenza
Pharmacological Actions : Immunomodulatory, Immunostimulatory
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Mushroom extracts decrease bone resorption and improve bone formation.Dec 31, 2015

Pubmed Data : Int J Med Mushrooms. 2016 ;18(7):559-69. PMID: 27649725
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom, Oyster Mushroom, Shiitake Mushroom
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Osteoprotective
Additional Keywords : Plant Extracts
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Novel medicinal mushroom blend as a promising supplement in integrative oncology.May 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 May 14 ;21(10). Epub 2020 May 14. PMID: 32423132
Article Published Date : May 13, 2020
Study Type : Animal Study
Additional Links
Substances : Agaricus Blazei, Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation
[+]

Purified β-glucans from the Shiitake mushroom ameliorates antibiotic-resistant Klebsiella pneumoniae-induced pulmonary sepsis.Sep 30, 2020

Pubmed Data : Lett Appl Microbiol. 2020 Oct ;71(4):405-412. Epub 2020 Aug 14. PMID: 32706908
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-glucan, Shiitake Mushroom
Diseases : Klebsiella Infections, Sepsis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Shiitake and medium-chain triglyceride-rich plant oil work together to reduce lipid profiles and lecithin-cholesterol acyltransferase activity in serum.Apr 26, 2018

Pubmed Data : J Diet Suppl. 2018 Apr 27:1-12. Epub 2018 Apr 27. PMID: 29701491
Article Published Date : Apr 26, 2018
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : High Fat Diet
Pharmacological Actions : Hypolipidemic
Additional Keywords : Plant Oils
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Shiitake contains compounds with hypoglycemic activity in a rat model of type 1 diabetes. May 01, 2002

Pubmed Data : Biosci Biotechnol Biochem. 2002 May;66(5):937-42. PMID: 12092843
Article Published Date : May 01, 2002
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Diabetes Mellitus: Type 1, Triglycerides: Elevated
Pharmacological Actions : Hypoglycemic Agents
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Shiitake extract inhibits cancer cell proliferation possibly through a reduction in Natural Killer cell cytotoxicity. Oct 01, 2003

Pubmed Data : Actas Urol Esp. 2003 Oct;27(9):732-4. PMID: 19059811
Article Published Date : Oct 01, 2003
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Cancers: All
Additional Keywords : Antineoplastic Agents
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Shiitake extract significantly inhibits atherosclerosis development in a rabbit model. Jan 01, 2002

Pubmed Data : J Atheroscler Thromb. 2002;9(3):149-56. PMID: 12226557
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Arteriosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

Shiitake has antioxidant and liver-protective effects against paracetamol-induced liver damage.Jun 01, 2010

Pubmed Data : Molecules. 2010 Jun;15(6):4478-89. Epub 2010 Jun 23. PMID: 20657455
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Shiitake may serve as a potent therapeutic agent against inflammatory bowel disease.Mar 31, 2022

Pubmed Data : Arq Gastroenterol. 2022 Apr-Jun;59(2):288-295. PMID: 35830043
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Shiitake mushroom derived polysaccharide can partly reverse the age-altered composition of gut microbiota.Jul 31, 2015

Pubmed Data : Food Funct. 2015 Aug ;6(8):2653-63. Epub 2015 Jul 2. PMID: 26135107
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Aging
Pharmacological Actions : Immunomodulatory
Additional Keywords : Microbiota, Plant Extracts
[+]

Shiitake polysaccharide enhanced systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice.May 31, 2015

Pubmed Data : Food Funct. 2015 Jun ;6(6):2068-80. PMID: 26034783
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Pharmacological Actions : Immunomodulatory, Immunostimulatory
Additional Keywords : Gene Expression Regulation, Microbiota
[+]

Shiitake supplementation modulated the transcriptional profile of some genes involved in the cholesterol metabolism similarly to simvastatin.Mar 08, 2016

Pubmed Data : J Agric Food Chem. 2016 Mar 9 ;64(9):1910-20. Epub 2016 Mar 1. PMID: 26877235
Article Published Date : Mar 08, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
Additional Keywords : Gene Expression Regulation, Natural Substances Versus Drugs
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The results show the immunomodulatory, hepatoprotective, and antioxidant activities of L. edodes supplementation in hypercholesterolemia.Dec 31, 2016

Pubmed Data : Int J Med Mushrooms. 2017 ;19(11):981-990. PMID: 29345560
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Hypercholesterolemia
Pharmacological Actions : Antioxidants, Hepatoprotective, Immunomodulatory
[+]

The results suggest that the elm tree bark bioprocessed with mycelia of shiitake mushrooms has the potential to prevent and treat allergic asthma.Feb 02, 2016

Pubmed Data : J Agric Food Chem. 2016 Feb 3 ;64(4):773-84. Epub 2016 Jan 25. PMID: 26807923
Article Published Date : Feb 02, 2016
Study Type : Animal Study
Additional Links
Substances : Elm tree, Shiitake Mushroom
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Prophylactic Agents
Additional Keywords : Plant Extracts
[+]

Vitamin D-enriched Shiitake mushroom exerts a synergistic anti-inflammatory effect in an immune-mediated hepatitis model.Mar 29, 2016

Pubmed Data : J Med Food. 2016 Mar 30. Epub 2016 Mar 30. PMID: 27027234
Article Published Date : Mar 29, 2016
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom , Vitamin D
Diseases : Chemically-Induced Liver Damage, Hepatitis C, Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Natural Substance Synergy, Plant Extracts
Problem Substances : Concanavalin A
[+]

White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis mice.Jan 01, 2011

Pubmed Data : J Nutr. 2011 Jan;141(1):131-6. Epub 2010 Nov 24. PMID: 21106932
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom , White Button Mushroom
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

β-glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers.Oct 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Oct 17 ;8(49):86693-86709. Epub 2017 Sep 30. PMID: 29156828
Article Published Date : Oct 16, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Antiproliferative, Apoptotic, Breast Cancer, Shiitake Mushroom
[+]

β-glucans from Lentinus edodes could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.Nov 08, 2016

Pubmed Data : Food Funct. 2016 Nov 9 ;7(11):4614-4627. PMID: 27747357
Article Published Date : Nov 08, 2016
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

β-glucans from Lentinus edodes inhibited angiogenesis by suppressing VEGF expression, leading to slow progression of tumors.Jun 28, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Jun 29 ;6:28802. Epub 2016 Jun 29. PMID: 27353254
Article Published Date : Jun 28, 2016
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Animal Cancers, Tumors
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Bcl-2 protein down-regulation
[+]

A derivative of Lentinula edodes C 91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G 1 phase in breast cancer cells.Nov 30, 2020

Pubmed Data : Appl Microbiol Biotechnol. 2020 Dec ;104(23):10165-10179. Epub 2020 Oct 12. PMID: 33044599
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest
[+]

A proprietary shitake/rice bran extract, encourages human leukemic cells to programmed cell death.Nov 10, 2003

Pubmed Data : Cancer Lett. 2003 Nov 10;201(1):41-9. PMID: 14580685
Article Published Date : Nov 10, 2003
Study Type : In Vitro Study
Additional Links
Substances : Modified Arabinoxylan Rice Bran (MGN-3), Shiitake Mushroom
Diseases : Leukemia
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A shiitake/rice bran combination known as MGN-3 has potent anti-HIV activity. Feb 04, 1998

Pubmed Data : Biochem Biophys Res Commun. 1998 Feb 4;243(1):25-9. PMID: 9473473
Article Published Date : Feb 04, 1998
Study Type : In Vitro Study
Additional Links
Substances : Modified Arabinoxylan Rice Bran (MGN-3), Rice Bran, Shiitake Mushroom
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
[+]

Anti-cancer potential of edible/medicinal mushrooms in breast cancer. Jun 13, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Jun 14 ;24(12). Epub 2023 Jun 14. PMID: 37373268
Article Published Date : Jun 13, 2023
Study Type : Review
Additional Links
Substances : Cordyceps Militaris, Cordyceps sinensis, Oyster Mushroom, Reishi Mushroom, Shiitake Mushroom , Turkey Tail Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents
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Antigenotoxic and antioxidant potential of medicinal mushrooms against DNA damage induced by free radicals-an in vitro study.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mutat Res. 2019 Sep ;845:403078. Epub 2019 Aug 1. PMID: 31561902
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Agaricus Blazei, Cordyceps sinensis, Medicinal Mushrooms, Reishi Mushroom, Shiitake Mushroom , Turkey Tail Mushroom
Diseases : DNA damage, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Genoprotective
[+]

Antimicrobial, cytotoxic, anti-inflammatory, and antioxidant activity of culinary processed Shiitake medicinal mushroom.Dec 31, 2017

Pubmed Data : Int J Med Mushrooms. 2018 ;20(2):165-175. PMID: 29773008
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Antioxidants, Cytotoxic
[+]

Extracts from medicinal basidiomycetes mushrooms had anti-tumor activity against cancer cell lines. Dec 31, 2015

Pubmed Data : Int J Med Mushrooms. 2016 ;18(11):955-964. PMID: 28008808
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom
Diseases : Kidney Cancer, Laryngeal Cancer, Lung Cancer
Pharmacological Actions : Cytotoxic, Immunomodulatory
[+]

Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts.Oct 18, 2020

Pubmed Data : Food Chem. 2020 Oct 19:128344. Epub 2020 Oct 19. PMID: 33268175
Article Published Date : Oct 18, 2020
Study Type : In Vitro Study
Additional Links
Substances : Kombucha Tea, Shiitake Mushroom , Turkey Tail Mushroom
Pharmacological Actions : Immunomodulatory
Additional Keywords : Polysaccharides
[+]

In vitro anti SARS-CoV-2 activity and docking analysis of Pleurotus ostreatus, Lentinula edodes and Agaricus bisporus edible mushrooms.Dec 31, 2021

Pubmed Data : Infect Drug Resist. 2022 ;15:3459-3475. Epub 2022 Jul 2. PMID: 35813084
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Oyster Mushroom, Shiitake Mushroom , White Button Mushroom
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

L. edodes possesses anti-atherosclerotic bio-functionality that can be applied as functional food-based therapeutics against cardiovascular diseases.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2018 Dec ;25(8):1515-1523. Epub 2016 Feb 8. PMID: 30581314
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Atherosclerosis
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Lentin, a beta-glucan rich protein from shitake mushroom, demonstrates inhibitory effects on activity of HIV-1 reverse transcriptase and proliferation of leukemia cells.Dec 10, 2009

Pubmed Data : J Med Chem. 2009 Dec 10;52(23):7887-91. PMID: 19526990
Article Published Date : Dec 10, 2009
Study Type : In Vitro Study
Additional Links
Substances : Beta-glucan, Shiitake Mushroom
Diseases : HIV Infections, Leukemia
Pharmacological Actions : Anti-HIV Agents, Antifungal Agents
[+]

Lentin, a novel and potent antifungal protein from shitake mushroom exhibits inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells.Nov 14, 2003

Pubmed Data : Life Sci. 2003 Nov 14;73(26):3363-74. PMID: 14572878
Article Published Date : Nov 14, 2003
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Fungal Infection, HIV Infections, Leukemia
Pharmacological Actions : Antifungal Agents
Additional Keywords : Plant Extracts
[+]

Lentinan may be a potential pharmacological agent for preventing pancreatic β‐cell damage caused by oxidative stress.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2016 Oct ;20(10):1803-12. Epub 2016 Jul 22. PMID: 27444655
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Diabetes: Oxidative Stress
Pharmacological Actions : Pancreato Protective Agents
Additional Keywords : Dose Response
Problem Substances : Streptozotocin
[+]

Lentinan up-regulates microRNA-340 to promote apoptosis and autophagy of human osteosarcoma cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2018 ;11(8):3876-3883. Epub 2018 Aug 1. PMID: 31949775
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, MicroRNA modulator
Additional Keywords : Polysaccharides
[+]

Lentinus edodes mycelium polysaccharide inhibits AGEs-induced HUVECs pyroptosis.Apr 30, 2024

Pubmed Data : Int J Biol Macromol. 2024 May ;267(Pt 1):131387. Epub 2024 Apr 4. PMID: 38582470
Article Published Date : Apr 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Glycation Agents
Additional Keywords : Polysaccharides
[+]

Polysaccharides from Lentinus edodes exhibited inhibition of cell proliferation on HCT-116 and HeLa cells in vitro.Nov 30, 2016

Pubmed Data : Int J Biol Macromol. 2016 Dec ;93(Pt A):136-144. Epub 2016 May 28. PMID: 27246376
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Cervical Cancer, Colon Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Polysaccharides
[+]

Predicting the bioactive compounds of Lentinula edodes and elucidating its interaction with genes associated to obesity.Mar 14, 2024

Pubmed Data : Heliyon. 2024 Mar 15 ;10(5):e27363. Epub 2024 Mar 5. PMID: 38495166
Article Published Date : Mar 14, 2024
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Shiitake aqueous extracts have demonstrated direct inhibition of the proliferation of human breast cancer cells in vitro and immunostimulatory properties. Jun 01, 2008

Pubmed Data : Phytomedicine. 2008 Jun;15(6-7):512-9. Epub 2008 Feb 1. PMID: 18242970
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Immunomodulatory
[+]

Shiitake exhibits anti-platelet activity. Jan 01, 2004

Pubmed Data : Biofactors. 2004;22(1-4):177-9. PMID: 15630278
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Clotting
Pharmacological Actions : Platelet Aggregation Inhibitors
Additional Keywords : Plant Extracts
[+]

Shiitake inhibits the growth of breast and myeloma tumor cells. Mar 01, 2006

Pubmed Data : J Altern Complement Med. 2006 Mar;12(2):125-32. PMID: 16566671
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Breast Cancer, Cancers: All, Multiple Myeloma
Pharmacological Actions : Apoptotic, Cell cycle arrest
Additional Keywords : Selective Cytotoxicity
[+]

Shiitake polysaccharide fractions exhibited antiproliferative activity against the tested human tumor cell lines in a concentration-dependent manner.Dec 31, 2016

Pubmed Data : Int J Med Mushrooms. 2017 ;19(5):395-403. PMID: 28845769
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Breast Cancer, Gastric Cancer, Lung Cancer, Lymphoma, Osteosarcoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Dose Response, Polysaccharides
[+]

Shiitake potentiates intestinal immunity. Apr 01, 2007

Pubmed Data : Biomed Res. 2007 Apr;28(2):71-7. PMID: 17510491
Article Published Date : Apr 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Immunomodulatory
Additional Keywords : Plant Extracts
[+]

Shitake has significant antibacterial and antifungal activity. Feb 01, 2009

Pubmed Data : Complement Ther Clin Pract. 2009 Feb;15(1):5-7. Epub 2008 Dec 2. PMID: 19161947
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Bacterial Infections and Mycoses
Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents
[+]

Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(11):e0224740. Epub 2019 Nov 7. PMID: 31697749
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Immunomodulatory
Additional Keywords : Natural Substance Synergy
[+]

Therapeutic effects of medicinal mushrooms on gastric, breast, and colorectal cancer.Mar 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 Apr ;15(4):e37574. Epub 2023 Apr 14. PMID: 37193480
Article Published Date : Mar 31, 2023
Study Type : Review
Additional Links
Substances : Medicinal Mushrooms, Shiitake Mushroom , Turkey Tail Mushroom
Diseases : Breast Cancer, Colorectal Cancer, Gastric Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Chemoprotective Agents, Immunomodulatory
[+]

These findings highlight the mushroom's pharmacological potential in cancer treatment.Dec 31, 2017

Pubmed Data : Int J Med Mushrooms. 2018 ;20(1):31-46. PMID: 29604911
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Larynx Neoplasms
Pharmacological Actions : Antiproliferative , Apoptotic

Copyright: toa55 / 123RF Stock Photo

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