Shikonin

Name	AC	CK
Lung Cancer	15	26
Breast Cancer	13	17
Colon Cancer	13	17
Lipopolysaccharide-Induced Toxicity	11	16
Colorectal Cancer	11	14
Breast Cancer: Triple Negative	10	12
Cancers: All	9	12
Cancers: Drug Resistant	11	12
Rheumatoid Arthritis	8	12
Squamous cell carcinoma	2	11
Carcinoma: Non-Small-Cell Lung	9	9
Liver Cancer	9	9
Ovarian Cancer	7	9
Glioblastoma	3	8
Inflammation	7	8
Psoriasis	7	8
Wound Healing	4	8
Acute Myeloid Leukemia	3	7
Glioma	6	7
Arthritis	3	6
Asthma	3	6
Gastric Cancer	5	6
Leukemia	2	6
Liver Fibrosis	3	6
Esophageal Cancer	4	5
Nasopharyngeal Cancer	3	5
Non-Small-Cell Lung Carcinoma	3	5
Osteoporosis	3	5
Oxidative Stress	4	5
Pancreatic Cancer	3	5
Brain Inflammation	2	4
Burns	2	4
Cognitive Decline/Dysfunction	2	4
Heart Failure	2	4
Lung Injury: Acute	2	4
Melanoma	4	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Osteosarcoma	4	4
Scars	3	4
Spinal Cord Injuries	2	4
Acetaminophen (Tylenol) Toxicity	2	3
Alzheimer's Disease	2	3
Atherosclerosis	2	3
Bladder Cancer	3	3
Candida Albicans	3	3
Cervical Cancer	3	3
Cholangiocarcinoma	3	3
Chronic Myeloid Leukemia	3	3
Colitis	2	3
Kidney Cancer	3	3
Leukemia: Acute myelogenous leukemia (AML)	1	3
Osteoarthritis	2	3
Parkinson's Disease	2	3
Periodontal Diseases	3	3
Allergic Rhinitis	1	2
Anemia: Aplastic	1	2
Anxiety	1	2
Benzene Toxicity	1	2
Breast Cancer: Metastatic	1	2
Burkitt Lymphoma	1	2
Cancer Metastasis	1	2
Cerebral Hemorrhage	1	2
Cerebral Hypoperfusion	1	2
Cerebral Ischemia	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Depression	1	2
Diabetic Retinopathy	1	2
Gallbladder Cancer	1	2
Heat Stroke	1	2
Hepatic Steatosis	1	2
High Fat Diet	1	2
Hypertension: Pulmonary	1	2
Liver Damage	1	2
Liver Damage: Drug-Induced	1	2
Liver Injury: Ischemia/reperfusion	1	2
Lung Damage	1	2
Mastitis	1	2
Multiple Sclerosis	2	2
Myocardial Infarction	1	2
Oral Cancer	2	2
Pain	1	2
Rotavirus Infections	1	2
Sepsis	1	2
Skin Cancer	1	2
Skin Cancer: Prevention	1	2
Staphylococcus aureus infection	2	2
Testicular Injury: Chemical/Metal Induced	1	2
Ulcerative Colitis	1	2
Acne	1	1
Air Pollution Linked Toxicity	1	1
Aspergillosis	1	1
Atopic Dermatitis	1	1
Breast Cancer: Drug Resistant	1	1
Breast Cancer: estrogen receptor alpha-positive	1	1
Burns: Severe	1	1
Candida Infection	1	1
Chronic Obstructive Pulmonary Disease	1	1
Coronavirus Infection	1	1
Endometrial Cancer	1	1
Epstein-Barr Virus Infections	1	1
Escherichia coli Infections	1	1
Glioblastoma Multiforme	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Inflammatory Bowel Diseases	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lipid Peroxidation	1	1
Lymphoma	1	1
Macular Degeneration	1	1
Multiple Myeloma	1	1
Mycobacterium Tuberculosis	1	1
Myocardial Ischemia	1	1
Periodontal Wound Healing	1	1
Periodontitis	1	1
Pneumonia	1	1
Pregnancy Complications	1	1
Primary Effusion Lymphoma	1	1
Promyelocytic leukemia	1	1
Prostate Cancer	1	1
Retinoblastoma	1	1
Skin Cancer: Squamous Cell	1	1
Skin Diseases: Inflammatory	1	1
Stomach Cancer	1	1
Systemic Lupus Erythematosus	1	1
Testicular Cancer	1	1
Thyroid Cancer	1	1

Name	AC	CK
Apoptotic	89	109
Antiproliferative	73	103
Anti-Inflammatory Agents	47	75
Anti-metastatic	25	33
Tumor Necrosis Factor (TNF) Alpha Inhibitor	18	29
Chemosensitizer	23	27
Immunomodulatory	12	27
Interleukin-1 beta downregulation	14	25
Chemotherapeutic	18	24
Interleukin-6 Downregulation	12	20
Anti-Apoptotic	10	18
Antioxidants	12	17
Hepatoprotective	9	17
Autophagy Up-regulation	12	16
NF-kappaB Inhibitor	10	15
Neuroprotective Agents	8	15
Cardioprotective	7	12
MicroRNA modulator	10	12
Anti-Bacterial Agents	6	8
Anti-Fibrotic	4	8
Cell cycle arrest	6	8
Chemopreventive	6	8
Cytotoxic	5	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	8
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	8
Antineoplastic Agents	5	6
Cyclooxygenase 2 Inhibitors	3	6
Interleukin-17 downregulation	4	6
Glucose transporter-1 (GLUT1) expression down-regulation	1	5
Interleukin-10 upregulation	2	5
Interleukin-4 downregulation	2	5
Tumor Suppressor Protein p53 Upregulation	5	5
Autophagy Inhibitors	2	4
Chemoprotective Agents	2	4
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	4
Nrf2 activation	3	4
Osteoprotective	3	4
STAT3 Inhibitor	3	4
Anticarcinogenic Agents	2	3
Antimicrobial	3	3
Bcl-2 protein down-regulation	3	3
P21 Activation	2	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Analgesics	1	2
Angiogenesis Inducing Agents	1	2
Anti-Anxiety Agents	1	2
Antidepressive Agents	1	2
Antidiarrheals	1	2
Antihypertensive Agents	1	2
Antinoceceptive	1	2
Antiviral Agents	2	2
Caspase-3 Activation	2	2
Cytotoxicity	2	2
Gastrointestinal Agents	1	2
Gastroprotective	1	2
Heat Shock Protein Inducer	1	2
Heme oxygenase-1 up-regulation	2	2
Interleukin-8 downregulation	2	2
Osteogenic	2	2
Vascular Endothelial Growth Factor Inhibitors	1	2
interleukin-13 down-regulation	1	2
Angiogenesis Inhibitors	1	1
Anti-Angiogenic	1	1
Antifungal Agents	1	1
Caspase-8 activation	1	1
Caspase-9 Activation	1	1
Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation	1	1
Chemotherapeuticm	1	1
Chondroprotective	1	1
Cytoprotective	1	1
Enzyme Inhibitors	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Interferon Gamma Reducer	1	1
Interleukin-10 downregulation	1	1
Interleukin-22 Downregulation	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
Topoisomerase I inhibitor	1	1
Topoisomerase II Inhibitor	1	1
Tumor Suppressor Protein p73 Upregulation	1	1
anti-inflammatory	1	1

Additional Keywords : Anti-metastatic, Antiproliferative, Chemotherapeutic Synergy: Temozolomide, Glioblastoma, Shikonin

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Shikonin induces apoptosis in HL-60 cells without significant effect on primary cells from healthy volunteers.Jul 14, 2016

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Pubmed Data : Cell Physiol Biochem. 2016 Jul 15 ;39(2):604-616. Epub 2016 Jul 15. PMID: 27415599

Article Published Date : Jul 14, 2016

Study Type : Human In Vitro

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Substances : Shikonin

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Apoptotic

Additional Keywords : Dose Response

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PLA-HPG based coating enhanced anti-biofilm and wound healing of Shikonin in MRSA-infected burn wound.Dec 31, 2022

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Pubmed Data : Pak J Pharm Sci. 2020 Nov ;33(6):2527-2533. PMID: 33867326

Article Published Date : Oct 31, 2020

Study Type : Animal Study

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Substances : Shikonin

Diseases : High Fat Diet, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Effects of shikonin on the functions of myeloid dendritic cells in a mouse model of severe aplastic anemia.Dec 31, 2019

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Pubmed Data : Zhongguo Gu Shang. 2024 Jan 25 ;37(1):61-8. PMID: 38286453

Article Published Date : Jan 24, 2024

Study Type : Animal Study

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Substances : Shikonin

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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Natural shikonin potentially alters intestinal flora to alleviate acute inflammation.Aug 22, 2023

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Pubmed Data : Phytomedicine. 2024 Sep 12 ;135:156043. Epub 2024 Sep 12. PMID: 39366155

Article Published Date : Sep 11, 2024

Study Type : Animal Study

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Substances : Shikonin

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Damage

Pharmacological Actions : Anti-Inflammatory Agents

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Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages.Dec 31, 2021

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Pubmed Data : Biomed Pharmacother. 2019 Feb 25 ;112:108704. Epub 2019 Feb 25. PMID: 30818140

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Pubmed Data : Sci Rep. 2016 Dec 1 ;6:38267. Epub 2016 Dec 1. PMID: 27905569

Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation.Jan 05, 2024

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Pubmed Data : Oncol Rep. 2019 Mar ;41(3):2020-2026. Epub 2019 Jan 11. PMID: 30664166

Article Published Date : Feb 28, 2019

Study Type : Animal Study, In Vitro Study

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Substances : Shikonin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic

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Shikonin induces apoptosis and G0/G1 phase arrest of gallbladder cancer cells.Nov 30, 2017

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Pubmed Data : Oncol Rep. 2017 Dec ;38(6):3473-3480. Epub 2017 Oct 17. PMID: 29039581

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Pubmed Data : Sci Rep. 2018 Feb 20 ;8(1):3317. Epub 2018 Feb 20. PMID: 29463831

Article Published Date : Feb 19, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Shikonin

Diseases : Burkitt Lymphoma

Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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Shikonin may be used as an adjuvant to cyclophosphamide in cancer treatment.Nov 03, 2024

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Pubmed Data : J Pharm Pharmacol. 2024 Nov 4 ;76(11):1482-1496. PMID: 39245439

Article Published Date : Nov 03, 2024

Study Type : Animal Study

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Substances : Shikonin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Chemoprotective Agents

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Shikonin relieves osteoporosis of ovariectomized mice.May 26, 2020

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Pubmed Data : Exp Cell Res. 2020 May 27:112115. Epub 2020 May 27. PMID: 32473224

Article Published Date : May 26, 2020

Study Type : Animal Study

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Substances : Shikonin

Diseases : Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Shikonin suppressed chemically induced skin carcinogenesis in this animal study. Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(5):e0126459. Epub 2015 May 11. PMID: 25961580

TEM1-targeting PEGylated PLGA shikonin nanoformulation for immunomodulation and eradication of ovarian cancer.Dec 31, 2021

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Pubmed Data : Phytomedicine. 2021 Feb ;82:153460. Epub 2021 Jan 8. PMID: 33476976

Article Published Date : Jan 31, 2021

Study Type : Animal Study

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Substances : Shikonin

Diseases : Colon Cancer

Pharmacological Actions : Chemopreventive

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Codelivery of Shikonin and siTGF-β for enhanced triple negative breast cancer chemo-immunotherapy.Jan 10, 2022

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Pubmed Data : J Control Release. 2022 Jan 11. Epub 2022 Jan 11. PMID: 35031387

Article Published Date : Jan 10, 2022

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Immunomodulatory

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Combination of shikonin and gefitinib reverses drug resistance in human non-small cell lung cancer and its mechanism.Dec 31, 2023

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2024 Jan ;49(1):175-184. PMID: 38403350

Article Published Date : Dec 31, 2023

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Gefitinib

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Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells.Dec 31, 2018

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Pubmed Data : Emerg Microbes Infect. 2016 ;5(8):e88. Epub 2016 Aug 17. PMID: 27530748

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Pubmed Data : Comput Biol Med. 2022 Aug ;147:105789. Epub 2022 Jun 30. PMID: 35797892

Article Published Date : Jul 31, 2022

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic

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Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.Dec 31, 2020

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Pubmed Data : Am J Cancer Res. 2021 ;11(7):3575-3593. Epub 2021 Jul 15. PMID: 34354861

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative

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Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.Apr 04, 2017

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Pubmed Data : Sci Rep. 2017 Apr 5 ;7:45983. Epub 2017 Apr 5. PMID: 28378811

Article Published Date : Apr 04, 2017

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Antiproliferative, Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin, Dose Response, Shikonin

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Pubmed Data : Front Pharmacol. 2024 ;15:1416781. Epub 2024 Jul 11. PMID: 39076592

Article Published Date : Dec 31, 2023

Study Type : Review

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Substances : Shikonin

Diseases : Cancers: All, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemopreventive

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RIP1 and RIP3 contribute to shikonin-induced glycolysis suppression in glioma cells.Jun 30, 2018

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Pubmed Data : Cancer Lett. 2018 Jul 1 ;425:31-42. Epub 2018 Mar 30. PMID: 29608987

Shikonin and Alkannin inhibit ATP synthase and impede the cell growth in Escherichia coli.Sep 24, 2023

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Pubmed Data : Int J Biol Macromol. 2023 Sep 25 ;253(Pt 4):127049. Epub 2023 Sep 25. PMID: 37758110

Article Published Date : Sep 24, 2023

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Escherichia coli Infections

Pharmacological Actions : Anti-Bacterial Agents

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Pubmed Data : Pharmacol Res. 2016 Nov 15 ;115:45-55. Epub 2016 Nov 15. PMID: 27864022

Article Published Date : Nov 14, 2016

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Apoptotic

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Shikonin enhances Adriamycin antitumor effects in A549 cells.Sep 30, 2017

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Pubmed Data : Pharmacogn Mag. 2015 Apr-Jun;11(42):250-6. PMID: 25829762

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

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Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

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Shikonin has anti-inflammatory effects on collagen-induced arthritis.Dec 31, 2017

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Pubmed Data : J Pharm Pharmacol. 2024 Apr 23. Epub 2024 Apr 23. PMID: 38652046

Article Published Date : Apr 22, 2024

Study Type : Review

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Substances : Shikonin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Immunomodulatory

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Shikonin induced apoptosis and autophagy in A375 cells.Nov 30, 2019

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Pubmed Data : Biomol Ther (Seoul). 2016 May 31. Epub 2016 May 31. PMID: 27257011

Article Published Date : May 30, 2016

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Stomach Cancer

Pharmacological Actions : Apoptotic, NF-E2-Related Factor-2 (Nrf2) Modulator, Tumor Suppressor Protein p53 Upregulation

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Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.Dec 31, 2021

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Pubmed Data : J Ethnopharmacol. 2020 Jul 11:113059. Epub 2020 Jul 11. PMID: 32663591

Article Published Date : Jul 10, 2020

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Glioma

Pharmacological Actions : Apoptotic

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Shikonin inhibited cell growth and caused cell cycle arrest of the A431 cells through the regulation of apoptosis.Dec 31, 2014

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Pubmed Data : Med Sci Monit. 2018 Feb 1 ;24:661-670. Epub 2018 Feb 1. PMID: 29389913

Article Published Date : Jan 31, 2018

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Thyroid Cancer

Pharmacological Actions : Anti-metastatic

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Shikonin inhibits migration and invasion of triple-negative breast cancer cells.Dec 31, 2020

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Pubmed Data : J Cancer. 2021 ;12(1):76-88. Epub 2021 Jan 1. PMID: 33391404

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic

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Pubmed Data : Molecules. 2016 Jun 16 ;21(6). Epub 2016 Jun 16. PMID: 27322220

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Pubmed Data : Anticancer Res. 2020 Sep ;40(9):5115-5124. PMID: 32878800

Article Published Date : Aug 31, 2020

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Cholangiocarcinoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:620383. Epub 2015 Feb 9. PMID: 25737737

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

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Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Dose Response

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Shikonin promotes apoptosis and attenuates migration and invasion of human esophageal cancer cells.Dec 31, 2020

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Pubmed Data : J Cancer. 2021 ;12(22):6814-6824. Epub 2021 Sep 24. PMID: 34659570

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Bladder Cancer

Pharmacological Actions : Anti-metastatic

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Shikonin triggers GSDME-mediated pyroptosis in tumours.Dec 31, 2022

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Shikonin-mediated up-regulation of miR-34a and miR-202 inhibits retinoblastoma proliferation.Aug 31, 2018

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Pubmed Data : Toxicol Res (Camb). 2018 Sep 1 ;7(5):907-912. Epub 2018 Jun 6. PMID: 30310667

Article Published Date : Aug 31, 2018

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Retinoblastoma

Pharmacological Actions : Antiproliferative , MicroRNA modulator

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Synergistic cytotoxicity of shikonin-silver nanoparticles as an opportunity for lung cancer.Nov 29, 2019

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Pubmed Data : J Labelled Comp Radiopharm. 2019 Nov 30. Epub 2019 Nov 30. PMID: 31785206

Article Published Date : Nov 29, 2019

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance Synergy

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Systematic bioinformatics analysis reveals the role of shikonin in blocking colon cancer progression.Dec 31, 2023

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Pubmed Data : Exp Ther Med. 2020 Nov ;20(5):45. Epub 2020 Sep 3. PMID: 32952636

Article Published Date : Oct 31, 2020

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Chronic Obstructive Pulmonary Disease, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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The role of Shikonin in improving 5-aminolevulinic acid-based photodynamic therapy and chemotherapy on glioblastoma stem cells.Jun 25, 2022

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Pubmed Data : Photodiagnosis Photodyn Ther. 2022 Jun 26 ;39:102987. Epub 2022 Jun 26. PMID: 35760350

Article Published Date : Jun 25, 2022

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Glioblastoma

Therapeutic Actions : Photodynamic therapy

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Cancer Stem Cells

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The study reveals for the first time the molecular mechanism in which shikonin mediates colorectal cancer progression.Dec 31, 2021

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Pubmed Data : Cell Physiol Biochem. 2018 May 24 ;47(3):981-993. Epub 2018 May 24. PMID: 29843123

Article Published Date : May 23, 2018

Study Type : In Vitro Study

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Substances : Shikonin

Diseases : Chronic Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Dose Response

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These results provide in-depth insight into the mechanisms of action of shikonin in the treatment of cancer.Jan 31, 2018

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View the Evidence: 261 Abstracts with Shikonin Research

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Shikonin could inhibit the growth of lung cancer and improve the immune function of the body and could be a safe and effective treatment.Sep 30, 1991

Regulation of glucose metabolism could serve as a new tumour suppressor mechanism.Dec 09, 2016

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.Apr 10, 2017

Shikonin induces apoptosis in HL-60 cells without significant effect on primary cells from healthy volunteers.Jul 14, 2016

PLA-HPG based coating enhanced anti-biofilm and wound healing of Shikonin in MRSA-infected burn wound.Dec 31, 2022

Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism.Dec 31, 2023

Shikonin exerts anti-leukemia effects in human CBF-AML cell lines.Sep 30, 2024

Shikonin suppresses rheumatoid arthritis by inducing apoptosis and autophagy.May 31, 2024

Anti-angiogenic effect of shikonin in rheumatoid arthritis.May 31, 2020

Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis.Dec 31, 2020

Effects of shikonin from Zicao on high-fat diet-induced nonalcoholic fatty liver disease in rats.Oct 31, 2020

Effects of shikonin on the functions of myeloid dendritic cells in a mouse model of severe aplastic anemia.Dec 31, 2019

Immune modulation of shikonin in a rat allergic rhinitis modelOct 19, 2016

Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance.Aug 06, 2023

Mechanism of Shikonin on spinal cord injury.Jan 24, 2024

Natural shikonin potentially alters intestinal flora to alleviate acute inflammation.Aug 22, 2023

oral administration of shikonin in a mouse collagen antibody-induced model of RA led to a dose-dependent inhibition of arthritic disease.Dec 31, 2014

Protective effect of shikonin in myocardial ischemia/reperfusion injury.Jan 11, 2022

Regulation of glycolysis and the Warburg effect in wound healing.Sep 02, 2020

Senescence inducer shikonin ROS-dependently suppressed lung cancer progression.Dec 31, 2017

Shikonin acts as a chemopreventive agent in the azoxymethane/dextran sulfate sodium model.Apr 10, 2018

Shikonin alleviates allergic airway remodeling by inhibiting the ERK-NF-κB signaling pathway.Jun 30, 2017

Shikonin alleviates collagen-induced arthritis mice by inhibiting M1 macrophage polarization.Nov 30, 2022

Shikonin alleviates doxorubicin-induced cardiotoxicity.Jan 08, 2024

Shikonin ameliorated LPS-induced acute lung injury.Sep 11, 2024

Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages.Dec 31, 2021

Shikonin ameliorates depressive- and anxiogenic-like behaviors.Aug 09, 2024

Shikonin ameliorates lipoteichoic acid‑induced acute lung injury.Dec 31, 2020

Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF-κB signalling pathways in a model of Parkinson's disease.Jul 31, 2022

Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells.Dec 31, 2019

Shikonin attenuated a high fat diet-induced nonalcoholic fatty liver disease.Apr 16, 2020

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.Mar 20, 2017

Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation.Feb 24, 2019

Shikonin attenuates cerebral ischemia/reperfusion injury.May 31, 2024

Shikonin attenuates chronic cerebral hypoperfusion-induced cognitive impairment.Dec 31, 2020

Shikonin attenuates sympathetic remodeling in chronic heart failure.Oct 07, 2019

Shikonin blocks CAF-induced TNBC metastasis.Jun 26, 2024

Shikonin could be a lead compound in the treatment of rotaviral secretory diarrhoea.Dec 31, 2015

Shikonin could be a novel therapeutic strategy against non-small cell lung cancer.May 30, 2017

Shikonin could be a promising antioxidant candidate for age-associated neurodegenerative diseases.Apr 08, 2020

Shikonin could be developed as a potential pain blocker.Jun 30, 2016

Shikonin enhances the chemotherapeutic sensitivity of gastric cancer cells to 5-fluorouracil and oxaliplatin.Nov 30, 2016

Shikonin exerts anti-inflammatory effects in lipopolysaccharides-induced mastitis.Oct 19, 2018

Shikonin has a significant antitumor effect in the ESCC by suppressing PKM2 mediated aerobic glycolysis and regulating PKM2/STAT3 signal pathway.Dec 31, 2020

Shikonin has been shown to strongly stimulate the induction of tumor immunogenicity.May 26, 2016

Shikonin improved experimental pulmonary arterial hypertension hemodynamics and pulmonary vascular remodeling.Feb 28, 2023

Shikonin improved sepsis induced lung injury by regulation miRNA-140-5p/TLR4.Nov 25, 2019

Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation.Jan 05, 2024

Shikonin induced DNA double-strand breaks in glioma cells.Mar 31, 2017

Shikonin induced the recovery of tissue repair and motor function after spinal cord injury.Dec 31, 2016

Shikonin induces an anti‑tumor effect on murine mammary cancer via p38‑dependent apoptosis.Feb 28, 2019

Shikonin induces apoptosis and G0/G1 phase arrest of gallbladder cancer cells.Nov 30, 2017

Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z.May 31, 2017

Shikonin inhibited immune evasion in pancreatic cancer by inhibiting PD-L1 glycosylation.Mar 31, 2021

Shikonin inhibited the viability, migration and invasion of SW480 cells.Feb 14, 2017

Shikonin inhibits cancer cell cycling by targeting Cdc25s.Jan 06, 2019

Shikonin inhibits cancer through P21 upregulation and apoptosis induction.Dec 31, 2019

shikonin inhibits tumor growth in mice by suppressing PKM2-mediated aerobic glycolysis.Sep 27, 2018

Shikonin is a promising candidate for treatment of postmenopausal osteoporosis.May 31, 2020

Shikonin is effective to ameliorate atherosclerosis in HHcy-ApoE-/- mice.Oct 12, 2019

Shikonin may be a promising candidate as a chemosensitizer to cisplatin-based therapy for cancer treatments.Dec 28, 2015

Shikonin may be an encouraging chemotherapeutic agent in the clinical treatment of Burkitt's lymphoma.Feb 19, 2018

Shikonin may be used as an adjuvant to cyclophosphamide in cancer treatment.Nov 03, 2024

Shikonin may represent a novel agent to treat nasopharyngeal carcinoma.Dec 31, 2018

Shikonin mediates apoptosis through G protein-coupled estrogen receptor of ovarian cancer cells.Dec 31, 2021

Shikonin might serve as a potential novel therapeutic drug in the treatment of human colon cancer.Dec 11, 2017

Shikonin potentiates skin wound healing.Nov 27, 2023

Shikonin pre-treatment attenuates concanavalin A induced acute liver injury by inhibiting apoptosis and autophagy.Dec 31, 2015

Shikonin prevents mice from heat stroke-induced death.Aug 26, 2023

Shikonin protects against D-Galactosamine and lipopolysaccharide-induced acute hepatic injury.Oct 30, 2017

Shikonin reduced the activation and expression of STAT3, FAK and Src in vivo and reduced tumorigenicity, growth and metastasis of 4T1 cells.Dec 31, 2014

Shikonin relieves osteoporosis of ovariectomized mice.May 26, 2020

Shikonin

View the Evidence:
261 Abstracts with Shikonin Research