Silymarin

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54 Diseases Researched for Silymarin
NameACCKFocus
Nonalcoholic fatty liver disease (NAFLD) 756Locked
Breast Milk: Inadequate/Poor Quality230Locked
Hepatitis C220Locked
Liver Cancer312Locked
Liver Damage: Drug-Induced212Locked
Liver Disease212Locked
Colorectal Cancer211Locked
AST: Elevated110Locked
Anxiety Disorders110Locked
Coronary Bypass Surgery110Locked
Depression110Locked
Diabetes Mellitus: Type 2110Locked
Elevated: ALT110Locked
Prostate Cancer: Surgery110Locked
Radiation Induced Illness: Mucositis110Locked
Radiodermatitis110Locked
Thalassemia110Locked
Tuberculosis110Locked
Oxidative Stress47Locked
Chemically-Induced Liver Damage36Locked
Liver Damage36Locked
Inflammation15Locked
Depression24Locked
Tuberculosis Drug Induced Toxicity 24Locked
Alcohol Toxicity 12Locked
Bisphenol Toxicity12Locked
Cancers: Drug Resistant22Locked
Chemotherapy and Radiation Toxicity12Locked
Chemotherapy-Induced Toxicity: Cisplatin12Locked
Chemotherapy-Induced Toxicity: Gentamicin12Locked
Chemotherapy-Induced Toxicity: Irinotecan12Locked
Insulin Resistance12Locked
Liver Cirrhosis12Locked
Liver Fibrosis12Locked
Lung Cancer12Locked
Metabolic Diseases12Locked
Obesity12Locked
Pesticide Toxicity 12Locked
Traumatic Brain Injury12Locked
Acrylamide-induced toxicity11Locked
Aging11Locked
Breast Cancer11Locked
Breast Cancer: Triple Negative 11Locked
Candida Albicans11Locked
Chikungunya Virus11Locked
Colon Cancer11Locked
Diabetic Complications11Locked
Escherichia coli Infections11Locked
Human Papillomavirus (HPV)11Locked
Leukemia11Locked
Liver Diseases11Locked
Pseudomonas aeruginosa11Locked
Staphylococcus aureus infection11Locked
Uranium Poisoning11Locked
39 Pharmacological Actions Researched for Silymarin
NameACCKFocus
Antioxidants1154Locked
Hepatoprotective1036Locked
Galactogogue230Locked
Radioprotective423Locked
Anti-Inflammatory Agents819Locked
Hypolipidemic314Locked
Antiviral Agents312Locked
Superoxide Dismutase Up-regulation212Locked
Anti-Fibrotic110Locked
Anticarcinogenic Agents110Locked
Hypoglycemic Agents110Locked
Insulin-Like Growth Factor Inhibition/Downregulation110Locked
Iron Chelating Agents110Locked
Prophylactic Agents110Locked
Antiproliferative 45Locked
Malondialdehyde Down-regulation35Locked
MicroRNA modulator15Locked
Antidepressive Agents24Locked
Chemoprotective Agents24Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor24Locked
Apoptotic33Locked
Chemopreventive33Locked
Neuroprotective Agents23Locked
Nrf2 activation23Locked
Brain-derived neurotrophic factor modulator12Locked
Chemotherapeutic12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-6 Downregulation12Locked
Regenerative12Locked
Renoprotective12Locked
Telomerase Inhibitor22Locked
Antimicrobial11Locked
Antineoplastic Agents11Locked
Chemosensitizer11Locked
Glutathione Upregulation 11Locked
Radiosensitizer11Locked
Telomerase Upregulation11Locked
Vascular Endothelial Growth Factor Inhibitors11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
110 Abstracts with Silymarin Research

[+]

Impact of silymarin in individuals with nonalcoholic fatty liver disease.Dec 31, 2020

Pubmed Data : Nutrition. 2021 03 ;83:111092. Epub 2020 Nov 25. PMID: 33418491
Article Published Date : Dec 31, 2020
Study Type : Meta Analysis, Review
Additional Links
Substances : Silymarin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Silymarin has positive efficacy to reduce transaminases levels in NAFLD patients.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2017 Dec ;96(49):e9061. PMID: 29245314
Article Published Date : Nov 30, 2017
Study Type : Meta Analysis
Additional Links
Substances : Silymarin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants
Additional Keywords : Antioxidants, Nonalcoholic fatty liver disease (NAFLD), Phytotherapy, SILYMARIN
[+]

Silymarin supplementation in combination with other treatments had a favorable effect on blood lipids.Mar 04, 2019

Pubmed Data : Phytother Res. 2019 Mar 5. Epub 2019 Mar 5. PMID: 30834633
Article Published Date : Mar 04, 2019
Study Type : Meta Analysis, Review
Additional Links
Substances : Silymarin
Diseases : Hyperlipidemia
Pharmacological Actions : Hypolipidemic
[+]

Systematic review of the efficacy of herbal galactogogues.Apr 30, 2013

Pubmed Data : J Hum Lact. 2013 May ;29(2):154-62. Epub 2013 Mar 6. PMID: 23468043
Article Published Date : Apr 30, 2013
Study Type : Meta Analysis
Additional Links
Substances : Fenugreek, Silymarin
Diseases : Breast Milk: Inadequate/Poor Quality
Pharmacological Actions : Galactogogue
[+]

"Protective effect of silymarin during coronary artery bypass grafting surgery."Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Clin Cardiol. 2012 ;17(1):34-8. PMID: 23204899
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Coronary Bypass Surgery
[+]

A silymarin-based cream may be a promising and effective treatment for the prevention of acute skin lesions caused by radiotherapy of breast cancer patients.Aug 01, 2011

Pubmed Data : Strahlenther Onkol. 2011 Aug ;187(8):485-91. Epub 2011 Jul 22. PMID: 21786113
Article Published Date : Aug 01, 2011
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Radiodermatitis
Pharmacological Actions : Radioprotective
Additional Keywords : Plant Extracts
[+]

Combined iron-chelation and silymarin therapy was effective for improving the iron-burden status in patients with β-thalassemia major.Dec 12, 2017

Pubmed Data : Phytother Res. 2017 Dec 13. Epub 2017 Dec 13. PMID: 29235162
Article Published Date : Dec 12, 2017
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Thalassemia
Pharmacological Actions : Iron Chelating Agents
[+]

Efficacy and safety of topical silymarin versus low fluence 1064-nm Q switched Nd:YAG laser in the treatment of melasma.Nov 30, 2021

Pubmed Data : Lasers Surg Med. 2021 Dec ;53(10):1341-1347. Epub 2021 Jun 8. PMID: 34101206
Article Published Date : Nov 30, 2021
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Melasma
Therapeutic Actions : Photobiomodulation
[+]

Evaluation of efficacy of cholecalciferol and silymarin in improving lower urinary tract symptoms of benign prostatic hyperplasia.Sep 01, 2024

Pubmed Data : Urologia. 2024 Sep 2:3915603241274467. Epub 2024 Sep 2. PMID: 39221555
Article Published Date : Sep 01, 2024
Study Type : Human Study
Additional Links
Substances : Silymarin, Vitamin D
Diseases : Prostatic Hyperplasia: Benign
[+]

Investigating the impact of silymarin on liver oxidative injury.Feb 29, 2020

Pubmed Data : J Family Med Prim Care. 2020 Mar ;9(3):1707-1711. Epub 2020 Mar 26. PMID: 32509676
Article Published Date : Feb 29, 2020
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Hypoxia, Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Oral silibinin, an IGF-1 binder, may result in lowered IGF-1 levels in liver and colorectal cancer patients as indicated by its accumulation in blood and tissue samples. May 01, 2006

Pubmed Data : Clin Cancer Res. 2006 May 1;12(9):2944-50. PMID: 16675592
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Substances : Milk Thistle, Silibinin, Silymarin
Diseases : Colorectal Cancer, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Insulin-Like Growth Factor Inhibition/Downregulation
[+]

Prophylactic administration of conventional form of silymarin tablets could significantly reduce the severity of radiotherapy induced mucositis.Aug 22, 2016

Pubmed Data : Phytother Res. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27555604
Article Published Date : Aug 22, 2016
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Radiation Induced Illness: Mucositis
Pharmacological Actions : Prophylactic Agents, Radioprotective
Additional Keywords : Significant Treatment Outcome
[+]

Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients.Sep 22, 2024

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep 23. Epub 2024 Sep 23. PMID: 39311921
Article Published Date : Sep 22, 2024
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Antibiotic Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Problem Substances : Antibiotics
[+]

Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety.Nov 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Psychiatry. 2016 Nov 15 ;16(1):398. Epub 2016 Nov 15. PMID: 27842532
Article Published Date : Nov 14, 2016
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Anxiety Disorders, Depression, Hepatitis C
Pharmacological Actions : Antioxidants, Antiviral Agents
Additional Keywords : Antioxidants, Antiviral Agents, Anxiety Disorders, Depression, hepatitis C, SILYMARIN
[+]

Silymarin and selenium are safe and effective in reducing two markers of lipid metabolism associated with prostate cancer progression after radical prostatectomy.Sep 01, 2010

Pubmed Data : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Sep;154(3):239-44. PMID: 21048810
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Selenium, Silymarin
Diseases : Prostate Cancer: Surgery
[+]

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):334. Epub 2015 Sep 23. PMID: 26400476
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Liver Damage: Drug-Induced, Tuberculosis
Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation
[+]

Silymarin in high dose is a good choice for improvement of liver biochemical profile and QoL in chronic hepatitis C virus cirrhotic patients.Oct 31, 2017

Pubmed Data : J Interferon Cytokine Res. 2017 Nov ;37(11):480-487. PMID: 29135373
Article Published Date : Oct 31, 2017
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Hepatitis C, Liver Disease
Pharmacological Actions : Hepatoprotective
[+]

Silymarin in non-cirrhotics with non-alcoholic steatohepatitis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(9):e0221683. Epub 2019 Sep 19. PMID: 31536511
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants
[+]

Silymarin is a potential effective supplementation for reducing toxicities in mCRC patients undergoing first-line FOLFIRI plus bevacizumab.Sep 06, 2021

Pubmed Data : Oncol Res. 2021 Sep 7 ;28(7):801-809. Epub 2021 May 24. PMID: 34030768
Article Published Date : Sep 06, 2021
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemoprotective Agents, Gastroprotective
[+]

Silymarin is effective in reduced ALT and AST in NAFLD.Jul 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Hepat Mon. 2012 Aug ;12(8):e6099. Epub 2012 Aug 3. PMID: 23087748
Article Published Date : Jul 31, 2012
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : AST: Elevated, Elevated: ALT, Nonalcoholic fatty liver disease (NAFLD)
[+]

Silymarin may reduce liver fibrosis.Apr 14, 2017

Pubmed Data : Clin Gastroenterol Hepatol. 2017 Apr 15. Epub 2017 Apr 15. PMID: 28419855
Article Published Date : Apr 14, 2017
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic
[+]

Silymarin monotherapy can be a therapeutic option for the treatment of acne vulgaris.Oct 02, 2019

Pubmed Data : Dermatol Ther. 2019 Oct 3:e13095. Epub 2019 Oct 3. PMID: 31579978
Article Published Date : Oct 02, 2019
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Acne
Pharmacological Actions : Antioxidants
[+]

Silymarin plus vitamin E could be beneficial in patients with non-alcoholic fatty liver disease.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2015 Aug ;19(16):3118-3124. PMID: 26367736
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Substances : Silymarin, Vitamin E
Diseases : Nonalcoholic fatty liver disease (NAFLD)
[+]

Silymarin significantly reduced interleukin-6 levels, sizes of endometrioma lesions, and pain-related symptoms.Oct 19, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Oct 20 ;12(1):17549. Epub 2022 Oct 20. PMID: 36266431
Article Published Date : Oct 19, 2022
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation
Additional Keywords : Significant Treatment Outcome
[+]

Silymarin-phosphatidylserine and galega increased milk production in mothers of preterm infants.Sep 30, 2016

Pubmed Data : Eur J Clin Nutr. 2016 Oct ;70(10):1151-1154. Epub 2016 Jun 1. PMID: 27245206
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Breast Milk: Inadequate/Poor Quality
Pharmacological Actions : Galactogogue
[+]

The combination of iron chelation therapy with silymarin can improve inflammatory status in patients with β-thalassemia major.Dec 31, 2020

Pubmed Data : Complement Med Res. 2021 ;28(2):123-130. Epub 2020 Sep 24. PMID: 32971524
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Inflammation, Thalassemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation
[+]

The effect of silymarin on liver enzymes in patients taking isotretinoin.Feb 29, 2020

Pubmed Data : Dermatol Ther. 2020 Mar ;33(2):e13236. Epub 2020 Feb 10. PMID: 31997509
Article Published Date : Feb 29, 2020
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Enzyme Inhibitors, Hepatoprotective
Problem Substances : Isotretinoin
[+]

This study showed a potential antihyperglycemic and triglyceride lowering effect of the herbal formulation.Dec 31, 2016

Pubmed Data : J Evid Based Complementary Altern Med. 2017 Jan 1:2156587217696929. Epub 2017 Jan 1. PMID: 29228792
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Nettle, Olibanum, Silymarin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Silymarin suppresses cellular inflammation by inducing reparative stress signaling.Aug 27, 2015

Pubmed Data : J Nat Prod. 2015 Aug 28 ;78(8):1990-2000. Epub 2015 Jul 17. PMID: 26186142
Article Published Date : Aug 27, 2015
Study Type : Human In Vitro
Additional Links
Substances : Silymarin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

Skin protective activity of silymarin and its flavonolignans.Mar 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Mar 14 ;24(6). Epub 2019 Mar 14. PMID: 30875758
Article Published Date : Mar 13, 2019
Study Type : Human In Vitro
Additional Links
Substances : Silymarin
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
[+]

Administration of silymarin significantly prevented acute liver injury induced by restraint stress.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 ;21(4). Epub 2016 Apr 1. PMID: 27043523
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Antioxidant actions of thymoquinone, silymarin, and curcumin on experimental aortic ischemia-reperfusion.Jun 02, 2022

Pubmed Data : Braz J Cardiovasc Surg. 2022 Jun 3. Epub 2022 Jun 3. PMID: 35657313
Article Published Date : Jun 02, 2022
Study Type : Animal Study
Additional Links
Substances : Curcumin, Silymarin, Thymoquinone
Diseases : Ischemia
Pharmacological Actions : Antioxidants
[+]

Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(2):e0147745. Epub 2016 Feb 16. PMID: 26881746
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Bisdemethoxycurcumin, Silymarin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
Additional Keywords : Natural Substance Synergy
[+]

Comparative study of the protective effects of citral, thymoquinone, and silymarin on methotrexate-induced cardiotoxicity.Sep 29, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2024 Sep 30 ;27(3):245-252. PMID: 39350925
Article Published Date : Sep 29, 2024
Study Type : Animal Study
Additional Links
Substances : Citral, Silymarin, Thymoquinone
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Cardioprotective
[+]

Comparison of the effects of thymoquinone and silymarin on the brain of rats having ischemia-reperfusion in the lower extremities.Nov 18, 2019

Pubmed Data : Ann Ital Chir. 2019 Nov 19 ;8. Epub 2019 Nov 19. PMID: 31769414
Article Published Date : Nov 18, 2019
Study Type : Animal Study
Additional Links
Substances : Silymarin, Thymoquinone
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Curcumin, silymarin and N-acetylcysteine protect against antitubercular drug-induced hepatotoxicity. Feb 08, 2012

Pubmed Data : Hum Exp Toxicol. 2012 Feb 8. Epub 2012 Feb 8. PMID: 22318308
Article Published Date : Feb 08, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin, NAC (N-acetyl-L-cysteine), Silymarin
Diseases : Tuberculosis Drug Induced Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Tubercular Drugs
[+]

Effective action of silymarin against ketamine-induced schizophrenia.Sep 11, 2024

Pubmed Data : J Psychiatr Res. 2024 Sep 12 ;179:141-155. Epub 2024 Sep 12. PMID: 39293119
Article Published Date : Sep 11, 2024
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Schizophrenia
Pharmacological Actions : Antipsychotic Agents
[+]

Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity.Jan 06, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2021 Jan 7 ;21(1):19. Epub 2021 Jan 7. PMID: 33413326
Article Published Date : Jan 06, 2021
Study Type : Animal Study
Additional Links
Substances : Coffee: Green/Unroasted, Silymarin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity.Nov 17, 2019

Pubmed Data : J Immunoassay Immunochem. 2019 Nov 18:1-13. Epub 2019 Nov 18. PMID: 31739724
Article Published Date : Nov 17, 2019
Study Type : Animal Study
Additional Links
Substances : Artichoke, Silymarin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterology Res. 2012 Oct ;5(5):190-194. Epub 2012 Sep 20. PMID: 27785204
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Silymarin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum-induced oxidative stress, hyperlipidemia, and genotoxicity.May 31, 2024

Pubmed Data : Environ Toxicol. 2024 Jun ;39(6):3746-3759. Epub 2024 Mar 28. PMID: 38546352
Article Published Date : May 31, 2024
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Aluminum Toxicity , Hyperlipidemia, Kidney Damage: Chemically-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Aluminum Chloride
[+]

Palmitoylethanolamide and silymarin treatment attenuated the degree of renal inflammation.Sep 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Sep 5 ;762:136-49. Epub 2015 May 14. PMID: 25981305
Article Published Date : Sep 04, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide , Silymarin
Diseases : Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
[+]

Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity.Mar 11, 2019

Pubmed Data : Drug Chem Toxicol. 2019 Mar 12:1-7. Epub 2019 Mar 12. PMID: 30862206
Article Published Date : Mar 11, 2019
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Renoprotective
Problem Substances : Vancomycin
[+]

Pretreatment with silymarin 2 h before cisplatin significantly decreased the pathological changes induced by cisplatin and appeared highly protective.May 14, 2010

Pubmed Data : Pak J Biol Sci. 2010 May 15 ;13(10):463-79. PMID: 21848071
Article Published Date : May 14, 2010
Study Type : Animal Study
Additional Links
Substances : Milk Thistle, Silymarin
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Chemotherapeutic
[+]

Protective effect of silymarin and gallic acid against cisplatin-induced nephrotoxicity and hepatotoxicity.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Pract. 2022 ;2022:6541026. Epub 2022 Apr 16. PMID: 35685593
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Gallic Acid, Silymarin
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, Renoprotective
[+]

Protective effects of combined β-caryophyllene and silymarin against ketoprofen-induced hepatotoxicity.Jun 30, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Jul ;94(7):739-44. Epub 2016 Mar 9. PMID: 27124106
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Silymarin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Additional Keywords : Beta-Caryophyllene, Hepatoprotective, Liver Damage: Drug-Induced, Plant Extracts, SILYMARIN
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity.Sep 04, 2019

Pubmed Data : Gene. 2019 Sep 5 ;712:143966. Epub 2019 Jul 4. PMID: 31279711
Article Published Date : Sep 04, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin, Silymarin
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Natural Substance Synergy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Radioprotective effects of Silymarin on the sperm parameters of NMRI mice irradiated with γ-rays.Dec 05, 2017

Pubmed Data : J Photochem Photobiol B. 2017 Dec 6 ;178:489-495. Epub 2017 Dec 6. PMID: 29232573
Article Published Date : Dec 05, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Radioprotective
[+]

Silybin is an effective component of silymarin for treating metabolic syndrome by stimulating FXR signalling.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:345. Epub 2016 Aug 28. PMID: 27733832
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Metabolic Diseases, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

Silymarin and melatonin can attenuate renal injury in rats treated with gentamicin.Dec 22, 2015

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26703224
Article Published Date : Dec 22, 2015
Study Type : Animal Study
Additional Links
Substances : Melatonin, Silymarin
Diseases : Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Malondialdehyde Down-regulation, Renoprotective
[+]

Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers.Feb 14, 2017

Pubmed Data : Pathophysiology. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28254270
Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aspartame
[+]

Silymarin can significantly reduce anxiety and depression-like symptoms, and neuroinflammation after mild traumatic brain injury.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 Jan 1 ;338:159-173. Epub 2017 Nov 22. PMID: 29175455
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Depression, Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Fluoxetine (trade name Prozac)
[+]

Silymarin could attenuate hepatic steatosis in a mouse model of NAFLD through regulation of lipid metabolism and oxidative stress.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2016 ;8(2):1073-81. Epub 2016 Feb 15. PMID: 27158393
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Nonalcoholic fatty liver disease (NAFLD), Oxidative Stress
Pharmacological Actions : Antioxidants, Hypolipidemic
[+]

Silymarin may exert protective effects against paraquat induced lung injury.Jul 13, 2015

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 Jul 14. Epub 2015 Jul 14. PMID: 26173462
Article Published Date : Jul 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Silymarin prevents memory impairments, anxiety, and depressive-like symptoms in a model of post-traumatic stress disorder.Dec 31, 2018

Pubmed Data : Planta Med. 2019 Jan ;85(1):32-40. Epub 2018 Aug 28. PMID: 30153692
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Anxiety, Depression, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Silymarin showed a dual effect on liver damage induced by irinotecan.Apr 24, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2017 Apr 25. Epub 2017 Apr 25. PMID: 28454924
Article Published Date : Apr 24, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Chemoprotective Agents, Hepatoprotective
Problem Substances : Irinotecan
[+]

Silymarin showed a significant anti-proliferative and pro-apoptotic role in benign prostatic hyperplasia.Jan 03, 2020

Pubmed Data : Pathol Oncol Res. 2020 Jan 4. Epub 2020 Jan 4. PMID: 31902118
Article Published Date : Jan 03, 2020
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Silymarin suppressed lung cancer growth in mice via inhibiting myeloid-derived suppressor cells.Jun 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jul ;81:460-7. Epub 2016 Apr 29. PMID: 27261626
Article Published Date : Jun 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative
[+]

Silymarin suppresses HepG2 hepatocarcinoma cell progression.Jan 31, 2020

Pubmed Data : Pharmacol Rep. 2020 Feb ;72(1):199-207. Epub 2020 Jan 8. PMID: 32016841
Article Published Date : Jan 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
Additional Keywords : Dose Response
[+]

Silymarin was sufficient to induce a protective effect against structural and ultrastructural injuries induced by BPA.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Mar ;13(3):821-828. Epub 2017 Jan 20. PMID: 28450905
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Bisphenol Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Bisphenol A
[+]

Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps.Apr 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2020 Apr 14 ;26(14):1601-1612. PMID: 32327909
Article Published Date : Apr 13, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin, Frankincense, Silymarin
Diseases : Intestinal Polyps
Pharmacological Actions : Chemopreventive
Additional Keywords : Natural Substance Synergy
[+]

Silymarin’s alleviation of inflammatory responses could be responsible for its benefits against liver damage and insulin resistance.Jul 07, 2016

Pubmed Data : Pharm Biol. 2016 Jul 8:1-6. Epub 2016 Jul 8. PMID: 27387273
Article Published Date : Jul 07, 2016
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Insulin Resistance, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Taurine may be used in combination with silymarin as an additional adjunct therapy to cure liver diseases such as fibrosis, cirrhosis and viral hepatitis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(12):e0144509. Epub 2015 Dec 11. PMID: 26659465
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Silymarin, Taurine
Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis, Liver Disease, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

The antioxidant and hepatoprotective potential of berberine and silymarin on acetaminophen induced toxicity.Jan 23, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Animals (Basel). 2024 Jan 24 ;14(3). Epub 2024 Jan 24. PMID: 38338016
Article Published Date : Jan 23, 2024
Study Type : Animal Study
Additional Links
Substances : Berberine, Silymarin
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

The hydroethanolic extract of Mucuna pruriens leaves possesses hepatoprotective activity.Mar 31, 2014

Pubmed Data : Chin J Nat Med. 2014 Apr ;12(4):273-83. PMID: 24863352
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Mucuna pruriens (aka Velvet Beans), Silymarin
Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Tuberculosis Drug Induced Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

The results demonstrate that silymarin protects against MPTP-induced changes in autophagy leading to Parkinsonism.Nov 14, 2019

Pubmed Data : J Mol Neurosci. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31732923
Article Published Date : Nov 14, 2019
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behaviour.Nov 30, 2017

Pubmed Data : J Psychopharmacol. 2017 Dec 1:269881117742666. Epub 2017 Dec 1. PMID: 29215318
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
[+]

These findings suggest that silymarin attenuates the severity of acute pancreatitis.Dec 31, 2019

Pubmed Data : Pancreas. 2020 Jan ;49(1):89-95. PMID: 31856083
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Pancreato Protective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings suggest that thymoquinone, silymarin, and N-acetylcysteine have potential for the treatment of diseases causing liver injury.Jul 29, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jul 30 ;106:1705-1712. Epub 2018 Jul 30. PMID: 30119245
Article Published Date : Jul 29, 2018
Study Type : Animal Study
Additional Links
Substances : Cysteine (see N-Acetylcysteine), Silymarin, Thymoquinone
Diseases : Liver Damage, Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

This study found that silymarin plays a crucial role in accelerated liver regeneration after partial hepatectomy.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:603529. Epub 2015 Aug 3. PMID: 26339266
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Liver Damage
Pharmacological Actions : Regenerative
[+]

Thymoquinone and silymarin is quite effective in preventing tissue damage in the brain following the ischemia reperfusion.Dec 31, 2019

Pubmed Data : Ann Ital Chir. 2020 ;91:131-136. PMID: 32180584
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Silymarin, Thymoquinone
Diseases : Brain Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

A number of plant polyphenols have chemosensitizing and radiosensitizing activity. Nov 01, 2005

Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. PMID: 16356126
Article Published Date : Nov 01, 2005
Study Type : Review
Additional Links
Substances : Betulinic acid, Caffeic acid phenethyl ester, Curcumin, Emodin, Flavonoids, Genistein, Green Tea, Polyphenols, Resveratrol, Silymarin, Ursolic Acid
Diseases : Cancers: Drug Resistant
Pharmacological Actions : Chemosensitizer, Radiosensitizer
[+]

A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds. Jul 31, 2011

Pubmed Data : Clin J Gastroenterol. 2011 Aug ;4(4):185-97. Epub 2011 Jun 4. PMID: 26189518
Article Published Date : Jul 31, 2011
Study Type : Review
Additional Links
Substances : Caffeine, Capsaicin, Cinnamaldehyde, Curcumin, Diallyl sulfide, EGCG (Epigallocatechin gallate), Genistein, Lycopene, Resveratrol, Silymarin, Sulforaphane, Xanthohumol
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

Antifibrotic effect of silymarin on arecoline-induced fibrosis in primary human buccal fibroblasts.Feb 14, 2024

Pubmed Data : Mol Biol Rep. 2024 Feb 15 ;51(1):303. Epub 2024 Feb 15. PMID: 38356030
Article Published Date : Feb 14, 2024
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antiproliferative
[+]

Antiviral activity of silymarin and baicalein against dengue virus.Oct 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Oct 27 ;11(1):21221. Epub 2021 Oct 27. PMID: 34707245
Article Published Date : Oct 26, 2021
Study Type : In Vitro Study
Additional Links
Substances : Baicalein, Silymarin
Diseases : Dengue
Pharmacological Actions : Antiviral Agents
[+]

Antivirals against chikungunya virus: Is the solution in nature?Jan 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Viruses. 2020 02 29 ;12(3). Epub 2020 Feb 29. PMID: 32121393
Article Published Date : Jan 28, 2020
Study Type : Review
Additional Links
Substances : Apigenin, Berberine, Chrysin, EGCG (Epigallocatechin gallate), Fisetin, Luteolin, Naringenin , Silibinin, Silymarin, Tannic Acid
Diseases : Chikungunya Virus
Pharmacological Actions : Antiviral Agents
[+]

Beta glucan and silymarin may protect against depleted uranium associated toxicity. Mar 01, 2011

Pubmed Data : Hum Exp Toxicol. 2011 Mar;30(3):173-81. Epub 2010 Jun 3. PMID: 20522489
Article Published Date : Mar 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Beta-glucan, Silymarin
Diseases : Uranium Poisoning
Pharmacological Actions : Radioprotective
[+]

Combinatorial treatments using phytochemicals are effective against colorectal cancer.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2016 ;7(10):1250-7. Epub 2016 Jun 23. PMID: 27390600
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Silymarin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Flavolignans from silymarin as Nrf2 bioactivators and their therapeutic applications. May 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2020 May 14 ;8(5). Epub 2020 May 14. PMID: 32423098
Article Published Date : May 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2.Mar 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33786876
Article Published Date : Mar 29, 2021
Study Type : Review
Additional Links
Substances : Biochanin A, Diosmin , EGCG (Epigallocatechin gallate), Epicatechin, Flavonoids, Genistein, Hesperidin, Luteolin, Naringenin , Quercetin, Rutin, Silymarin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Cytokine Storm
[+]

Flavonoids for treating pulmonary fibrosis: Present status and future prospects.Jul 09, 2024

Pubmed Data : Phytother Res. 2024 Jul 10. Epub 2024 Jul 10. PMID: 38986681
Article Published Date : Jul 09, 2024
Study Type : Review
Additional Links
Substances : Baicalein, Citrus naringin, Flavonoids, Kaempferol, Puerarin, Quercetin, Silymarin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications.Nov 30, 2021

Pubmed Data : Ren Fail. 2021 Dec ;43(1):351-361. PMID: 33593237
Article Published Date : Nov 30, 2021
Study Type : Review
Additional Links
Substances : Curcumin, Emodin, Quercetin, Resveratrol, Silymarin
Diseases : Chronic Kidney Disease (CKD)
Pharmacological Actions : Antioxidants
[+]

In a pooled analysis of trials in patients with cirrhosis, silymarin treatment was associated with a significant reduction in liver-related deaths.Feb 17, 2020

Pubmed Data : Adv Ther. 2020 Feb 17. Epub 2020 Feb 17. PMID: 32065376
Article Published Date : Feb 17, 2020
Study Type : Review
Additional Links
Substances : Milk Thistle, Silymarin
Diseases : Liver Disease
Pharmacological Actions : Hepatoprotective, Regenerative
Additional Keywords : Liver Regeneration
[+]

Lycopene, 6-gingerol, and silymarin are able to induce apoptosis and reduction of mitochondrial membrane potential in glioblastoma cells.Dec 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Dec 30 ;12(1). Epub 2019 Dec 30. PMID: 31905849
Article Published Date : Dec 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gingerol , Lycopene, Silymarin
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death.Jan 09, 2020

Pubmed Data : J Pharm Pharmacol. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31922618
Article Published Date : Jan 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid, Curcumin, EGCG (Epigallocatechin gallate), Gallic Acid, Naringenin , Piperine, Polyphenols, Quercetin, Rutin, Silymarin
Diseases : Drug-Induced Toxicity: Gastrointestinal, Drug-Induced Toxicity: Indomethacin
Pharmacological Actions : Antioxidants, Gastroprotective
Problem Substances : Diclofenac, Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Natural substances such as Aloe vera, cinnamon, green tea, fenugreek, and silymarin can be used as a new supportive care for PCOS.Mar 26, 2020

Pubmed Data : Biomol Concepts. 2020 Mar 26 ;11(1):57-75. Epub 2020 Mar 26. PMID: 32229652
Article Published Date : Mar 26, 2020
Study Type : Review
Additional Links
Substances : Aloe Vera, Cinnamon, Fenugreek, Green Tea, Silymarin
Diseases : Polycystic Ovary Syndrome
[+]

Piperine enhances the bioavailability of silybin.Sep 27, 2018

Pubmed Data : Phytomedicine. 2018 Sep 28 ;54:98-108. Epub 2018 Sep 28. PMID: 30668388
Article Published Date : Sep 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Piperine, Silymarin
Additional Keywords : Food Bioavailability Enhancers
[+]

Silibinin is a good sensitizing agent for rhTRAIL-resistant Triple-negative breast cancer.Jan 11, 2017

Pubmed Data : Anticancer Res. 2017 12 ;37(12):6593-6599. PMID: 29187434
Article Published Date : Jan 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Breast Cancer: Triple Negative , Cancers: Drug Resistant
Pharmacological Actions : Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Silymarin ameliorates diabetes-induced proangiogenic response in brain endothelial cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Diabetes Res. 2017 ;2017:2537216. Epub 2017 Oct 25. PMID: 29209632
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Diabetic Complications
Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors
[+]

Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:292797. Epub 2015 Mar 11. PMID: 25866771
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Silibinin, Silymarin
Diseases : Candida Albicans, Escherichia coli Infections, Pseudomonas aeruginosa, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy
[+]

Silymarin as an antioxidant therapy in chronic liver diseases.Jul 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2024 Aug ;16(8):e67083. Epub 2024 Aug 17. PMID: 39286715
Article Published Date : Jul 31, 2024
Study Type : Review
Additional Links
Substances : Silymarin
Diseases : Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Silymarin can effectively alleviate acrylamide induced neurotoxicity in PC12 cells.Mar 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Apr ;102:93-101. Epub 2017 Jan 27. PMID: 28137608
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Acrylamide-induced toxicity
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Malondialdehyde Down-regulation, Neuroprotective Agents, Nrf2 activation
Problem Substances : Acrylamide
[+]

Silymarin encapsulated nanoliquid crystals for improved activity against beta amyloid induced cytotoxicity.Feb 06, 2020

Pubmed Data : Int J Biol Macromol. 2020 Feb 7 ;149:1198-1206. Epub 2020 Feb 7. PMID: 32044368
Article Published Date : Feb 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Silymarin exhibited significant in vitro antiviral activity against chikungunya virus.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:11421. Epub 2015 Jun 16. PMID: 26078201
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Chikungunya Virus
Pharmacological Actions : Antiviral Agents
[+]

Silymarin impacts on immune system as an immunomodulator: One key for many locks.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:194-201. Epub 2017 Jun 30. PMID: 28672215
Article Published Date : Aug 31, 2017
Study Type : Review
Additional Links
Substances : Silymarin
Diseases : Allergies, Autoimmune Diseases, Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, NF-kappaB Inhibitor
[+]

Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2019 Nov ;42(5):1904-1914. Epub 2019 Aug 28. PMID: 31485597
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Silymarin inhibited DU145 cells by activating SLIT2 protein and suppressing expression of CXCR4.Feb 14, 2020

Pubmed Data : Med Oncol. 2020 Feb 15 ;37(3):18. Epub 2020 Feb 15. PMID: 32062757
Article Published Date : Feb 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Silymarin inhibits endothelial progenitor cell aging through telomerase upregulation. Aug 09, 2002

Pubmed Data : Life Sci. 2002 Aug 9;71(12):1385-96. PMID: 20838231
Article Published Date : Aug 09, 2002
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Aging
Pharmacological Actions : Telomerase Upregulation
[+]

Silymarin is an ally against insulin resistance: A review.Jun 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Hepatol. 2021 Jul-Aug;23:100255. Epub 2020 Sep 17. PMID: 32950646
Article Published Date : Jun 30, 2021
Study Type : Review
Additional Links
Substances : Silymarin
Diseases : Insulin Resistance
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Insulin Sensitizers
[+]

Silymarin restores regulatory T cells (Tregs) function in Multiple sclerosis patients in vitro.Jul 31, 2019

Pubmed Data : Inflammation. 2019 Aug ;42(4):1203-1214. PMID: 30806958
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Multiple Sclerosis
Pharmacological Actions : Antioxidants, Immunomodulatory
[+]

Silymarin was found to be able to inhibit telomerase activity in HepG2 cells.Feb 28, 2015

Pubmed Data : J BUON. 2015 Mar-Apr;20(2):555-61. PMID: 26011349
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Milk Thistle, Silymarin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
Additional Keywords : Plant Extracts
[+]

Silymarin, a popular dietary supplement shows anti-candida activity.Oct 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antibiotics (Basel). 2019 Oct 31 ;8(4). Epub 2019 Oct 31. PMID: 31683548
Article Published Date : Oct 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Candida Albicans, Candida Infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Silymarin-mediated downregulation of β-catenin and TCF4 may result in the inhibition of Wnt signalling in human colorectal cancer cells.Apr 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2016 Apr 11. Epub 2016 Apr 11. PMID: 27068260
Article Published Date : Apr 10, 2016
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Colorectal Cancer
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

The objective of this review is to provide information pertaining to various antioxidants found in food that have demonstrated utility in improving liver diseases. Aug 05, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastrointest Pharmacol Ther. 2015 Aug 6 ;6(3):59-72. PMID: 26261734
Article Published Date : Aug 05, 2015
Study Type : Review
Additional Links
Substances : Coffee, Curcumin, Naringenin , Quercetin, Resveratrol, Silymarin
Diseases : Liver Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic reviewAug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Sep ;22(9):968-976. PMID: 31807239
Article Published Date : Aug 31, 2019
Study Type : Review
Additional Links
Substances : Silymarin
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

The treatment of the K562 cells with silymarin resulted in a significant inhibition of cell growth and telomerase activity.May 31, 2012

Pubmed Data : Planta Med. 2012 Jun ;78(9):899-902. Epub 2012 Apr 24. PMID: 22532022
Article Published Date : May 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Telomerase Inhibitor
[+]

These natural inhibitors have been shown to block HPV infection and inhibition of HPV oncoproteins. May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genomics Inform. 2015 Jun ;13(2):60-7. Epub 2015 Jun 30. PMID: 26175664
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Artemisinin, Berberine, Curcumin, EGCG (Epigallocatechin gallate), Ferulic acid, Gingerol , Indole-3-Carbinol, Resveratrol, Silymarin, Ursolic Acid
Diseases : Human Papillomavirus (HPV)
Pharmacological Actions : Antiviral Agents, Chemopreventive
Additional Keywords : E6 Oncoprotein, Risk Reduction
[+]

This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives,Apr 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 19 ;24(8). Epub 2019 Apr 19. PMID: 31010179
Article Published Date : Apr 18, 2019
Study Type : Review
Additional Links
Substances : Silymarin
Diseases : Chikungunya Virus, Dengue, Hepatitis B , Hepatitis C, HIV Infections, Influenza
Pharmacological Actions : Antiviral Agents
[+]

Treatment of melasma: a review of less commonly used antioxidants.Aug 19, 2020

Pubmed Data : Int J Dermatol. 2020 Aug 20. Epub 2020 Aug 20. PMID: 32815582
Article Published Date : Aug 19, 2020
Study Type : Review
Additional Links
Substances : Ginseng (Korean), Grape Seed Extract, Niacinamide, Parsley, Pycnogenol (Pine Bark), Silymarin, Zinc
Diseases : Melasma
Pharmacological Actions : Antioxidants
[+]

Various plant substances inhibit chemically-induced mammary gland tumor promotion. Mar 01, 2008

Pubmed Data : Nutr Cancer. 2008 Mar-Apr;60(2):227-34. PMID: 1905902
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Beta Sitosterol, Curcumin, D-Limonene, DHEA (Dehydroepiandrosterone), Silymarin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Chemopreventive

Copyright: dole / 123RF Stock Photo

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