Silymarin

Name	AC	CK
Nonalcoholic fatty liver disease (NAFLD)	10	107
Breast Milk: Inadequate/Poor Quality	2	30
Liver Damage: Drug-Induced	6	28
Hyperlipidemia	2	22
Colorectal Cancer	3	21
Hepatitis C	3	21
Thalassemia	2	20
Liver Damage	6	19
Oxidative Stress	10	18
Inflammation	2	15
Liver Disease	4	15
Liver Cancer	4	14
Chemically-Induced Liver Damage	6	12
Prostatic Hyperplasia: Benign	2	12
Melasma	2	11
AST: Elevated	1	10
Acne	1	10
Antibiotic Toxicity	1	10
Anxiety Disorders	1	10
Coronary Bypass Surgery	1	10
Depression	1	10
Diabetes Mellitus: Type 2	1	10
Elevated: ALT	1	10
Endometriosis	1	10
Hypoxia	1	10
Kidney Damage: Drug-Induced	1	10
Prostate Cancer: Surgery	1	10
Radiation Induced Illness: Mucositis	1	10
Radiodermatitis	1	10
Tuberculosis	1	10
Acetaminophen (Tylenol) Toxicity	4	8
Depression	3	6
Aging Skin	1	5
Ischemia	3	5
Ultraviolet Radiation Induced Damage	1	5
Anxiety	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Kidney Damage: Chemically-Induced	2	4
Tuberculosis Drug Induced Toxicity	2	4
Chikungunya Virus	3	3
Insulin Resistance	2	3
Alcohol Toxicity	1	2
Aluminum Toxicity	1	2
Bisphenol Toxicity	1	2
Brain Ischemia	1	2
Cancers: Drug Resistant	2	2
Candida Albicans	2	2
Cerebral Ischemia	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chemotherapy-Induced Toxicity: Irinotecan	1	2
Dengue	2	2
Drug Toxicity: Methotrexate	1	2
Intestinal Polyps	1	2
Liver Cirrhosis	1	2
Liver Fibrosis	1	2
Lung Cancer	1	2
Metabolic Diseases	1	2
Obesity	1	2
Pancreatitis	1	2
Parkinson's Disease	1	2
Pesticide Toxicity	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Schizophrenia	1	2
Traumatic Brain Injury	1	2
Acrylamide-induced toxicity	1	1
Aging	1	1
Allergies	1	1
Alzheimer's Disease	1	1
Autoimmune Diseases	1	1
Breast Cancer	1	1
Breast Cancer: Triple Negative	1	1
Cancers: All	1	1
Candida Infection	1	1
Chronic Kidney Disease (CKD)	1	1
Colon Cancer	1	1
Coronavirus Infection	1	1
Diabetic Complications	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Escherichia coli Infections	1	1
Fibrosis	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
HIV Infections	1	1
Hepatitis B	1	1
Human Papillomavirus (HPV)	1	1
Influenza	1	1
Leukemia	1	1
Liver Diseases	1	1
Multiple Sclerosis	1	1
Polycystic Ovary Syndrome	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Pulmonary Fibrosis	1	1
Staphylococcus aureus infection	1	1
Uranium Poisoning	1	1

Name	AC	CK
Hepatoprotective	24	115
Antioxidants	29	105
Anti-Inflammatory Agents	20	54
Hypolipidemic	4	34
Galactogogue	2	30
Interleukin-6 Downregulation	4	24
Radioprotective	4	23
Renoprotective	6	20
Chemoprotective Agents	4	16
Antiviral Agents	6	15
Antiproliferative	10	13
Anti-Fibrotic	3	12
Superoxide Dismutase Up-regulation	2	12
Gastroprotective	2	11
Anticarcinogenic Agents	1	10
Apoptotic	8	10
Enzyme Inhibitors	1	10
Hypoglycemic Agents	1	10
Insulin-Like Growth Factor Inhibition/Downregulation	1	10
Interleukin-10 upregulation	1	10
Iron Chelating Agents	1	10
Neuroprotective Agents	6	10
Prophylactic Agents	1	10
Malondialdehyde Down-regulation	4	7
Antidepressive Agents	3	6
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	6
Chemopreventive	4	5
MicroRNA modulator	1	5
Photoprotective	1	5
Brain-derived neurotrophic factor modulator	2	4
Interleukin-1 beta downregulation	2	4
Nrf2 activation	3	4
NF-kappaB Inhibitor	2	3
Regenerative	2	3
Anti-Anxiety Agents	1	2
Anti-Apoptotic	1	2
Anti-metastatic	1	2
Antipsychotic Agents	1	2
Cardioprotective	1	2
Chemotherapeutic	1	2
Immunomodulatory	2	2
Pancreato Protective Agents	1	2
Telomerase Inhibitor	2	2
Anti-Bacterial Agents	1	1
Antimicrobial	1	1
Antineoplastic Agents	1	1
Chemosensitizer	1	1
Glutathione Upregulation	1	1
Insulin Sensitizers	1	1
Radiosensitizer	1	1
Telomerase Upregulation	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

The effectiveness of curcumin, resveratrol, and silymarin on MASLD.Nov 30, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Nutr. 2024 Dec ;12(12):10010-10029. Epub 2024 Nov 14. PMID: 39723101

Article Published Date : Nov 30, 2024

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin, Resveratrol, Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

Impact of silymarin in individuals with nonalcoholic fatty liver disease.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : Nutrition. 2021 03 ;83:111092. Epub 2020 Nov 25. PMID: 33418491

Article Published Date : Dec 31, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

Silymarin has positive efficacy to reduce transaminases levels in NAFLD patients.Nov 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicine (Baltimore). 2017 Dec ;96(49):e9061. PMID: 29245314

Article Published Date : Nov 30, 2017

Study Type : Meta Analysis

Additional Links

Substances : Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants

Additional Keywords : Antioxidants, Nonalcoholic fatty liver disease (NAFLD), Phytotherapy, SILYMARIN

[+]

Silymarin supplementation in combination with other treatments had a favorable effect on blood lipids.Mar 04, 2019

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2019 Mar 5. Epub 2019 Mar 5. PMID: 30834633

Article Published Date : Mar 04, 2019

Study Type : Meta Analysis, Review

Additional Links

Substances : Silymarin

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

[+]

Systematic review of the efficacy of herbal galactogogues.Apr 30, 2013

Click here to read the entire abstract

Pubmed Data : J Hum Lact. 2013 May ;29(2):154-62. Epub 2013 Mar 6. PMID: 23468043

Article Published Date : Apr 30, 2013

Study Type : Meta Analysis

Additional Links

Substances : Fenugreek, Silymarin

Diseases : Breast Milk: Inadequate/Poor Quality

Pharmacological Actions : Galactogogue

[+]

"Protective effect of silymarin during coronary artery bypass grafting surgery."Dec 31, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Clin Cardiol. 2012 ;17(1):34-8. PMID: 23204899

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Coronary Bypass Surgery

[+]

A silymarin-based cream may be a promising and effective treatment for the prevention of acute skin lesions caused by radiotherapy of breast cancer patients.Aug 01, 2011

Click here to read the entire abstract

Pubmed Data : Strahlenther Onkol. 2011 Aug ;187(8):485-91. Epub 2011 Jul 22. PMID: 21786113

Article Published Date : Aug 01, 2011

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Radiodermatitis

Pharmacological Actions : Radioprotective

Additional Keywords : Plant Extracts

[+]

Combined iron-chelation and silymarin therapy was effective for improving the iron-burden status in patients with β-thalassemia major.Dec 12, 2017

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Pubmed Data : Phytother Res. 2017 Dec 13. Epub 2017 Dec 13. PMID: 29235162

Article Published Date : Dec 12, 2017

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Thalassemia

Pharmacological Actions : Iron Chelating Agents

[+]

Efficacy and safety of topical silymarin versus low fluence 1064-nm Q switched Nd:YAG laser in the treatment of melasma.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Lasers Surg Med. 2021 Dec ;53(10):1341-1347. Epub 2021 Jun 8. PMID: 34101206

Article Published Date : Nov 30, 2021

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Melasma

Therapeutic Actions : Photobiomodulation

[+]

Evaluation of efficacy of cholecalciferol and silymarin in improving lower urinary tract symptoms of benign prostatic hyperplasia.Sep 01, 2024

Click here to read the entire abstract

Pubmed Data : Urologia. 2024 Sep 2:3915603241274467. Epub 2024 Sep 2. PMID: 39221555

Article Published Date : Sep 01, 2024

Study Type : Human Study

Additional Links

Substances : Silymarin, Vitamin D

Diseases : Prostatic Hyperplasia: Benign

[+]

Investigating the impact of silymarin on liver oxidative injury.Feb 29, 2020

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Pubmed Data : J Family Med Prim Care. 2020 Mar ;9(3):1707-1711. Epub 2020 Mar 26. PMID: 32509676

Article Published Date : Feb 29, 2020

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Hypoxia, Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

[+]

Oral silibinin, an IGF-1 binder, may result in lowered IGF-1 levels in liver and colorectal cancer patients as indicated by its accumulation in blood and tissue samples. May 01, 2006

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Pubmed Data : Clin Cancer Res. 2006 May 1;12(9):2944-50. PMID: 16675592

Article Published Date : May 01, 2006

Study Type : Human Study

Additional Links

Substances : Milk Thistle, Silibinin, Silymarin

Diseases : Colorectal Cancer, Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Insulin-Like Growth Factor Inhibition/Downregulation

[+]

Prophylactic administration of conventional form of silymarin tablets could significantly reduce the severity of radiotherapy induced mucositis.Aug 22, 2016

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27555604

Article Published Date : Aug 22, 2016

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Radiation Induced Illness: Mucositis

Pharmacological Actions : Prophylactic Agents, Radioprotective

Additional Keywords : Significant Treatment Outcome

[+]

Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients.Sep 22, 2024

Click here to read the entire abstract

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep 23. Epub 2024 Sep 23. PMID: 39311921

Article Published Date : Sep 22, 2024

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Antibiotic Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Antibiotics

[+]

Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety.Nov 14, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Psychiatry. 2016 Nov 15 ;16(1):398. Epub 2016 Nov 15. PMID: 27842532

Article Published Date : Nov 14, 2016

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Anxiety Disorders, Depression, Hepatitis C

Pharmacological Actions : Antioxidants, Antiviral Agents

Additional Keywords : Antioxidants, Antiviral Agents, Anxiety Disorders, Depression, hepatitis C, SILYMARIN

[+]

Silymarin and selenium are safe and effective in reducing two markers of lipid metabolism associated with prostate cancer progression after radical prostatectomy.Sep 01, 2010

Click here to read the entire abstract

Pubmed Data : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Sep;154(3):239-44. PMID: 21048810

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Selenium, Silymarin

Diseases : Prostate Cancer: Surgery

[+]

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):334. Epub 2015 Sep 23. PMID: 26400476

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Liver Damage: Drug-Induced, Tuberculosis

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

[+]

Silymarin in high dose is a good choice for improvement of liver biochemical profile and QoL in chronic hepatitis C virus cirrhotic patients.Oct 31, 2017

Click here to read the entire abstract

Pubmed Data : J Interferon Cytokine Res. 2017 Nov ;37(11):480-487. PMID: 29135373

Article Published Date : Oct 31, 2017

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Hepatitis C, Liver Disease

Pharmacological Actions : Hepatoprotective

[+]

Silymarin in non-cirrhotics with non-alcoholic steatohepatitis.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2019 ;14(9):e0221683. Epub 2019 Sep 19. PMID: 31536511

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants

[+]

Silymarin is a potential effective supplementation for reducing toxicities in mCRC patients undergoing first-line FOLFIRI plus bevacizumab.Sep 06, 2021

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Pubmed Data : Oncol Res. 2021 Sep 7 ;28(7):801-809. Epub 2021 May 24. PMID: 34030768

Article Published Date : Sep 06, 2021

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Colorectal Cancer

Pharmacological Actions : Chemoprotective Agents, Gastroprotective

[+]

Silymarin is effective in reduced ALT and AST in NAFLD.Jul 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Hepat Mon. 2012 Aug ;12(8):e6099. Epub 2012 Aug 3. PMID: 23087748

Article Published Date : Jul 31, 2012

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : AST: Elevated, Elevated: ALT, Nonalcoholic fatty liver disease (NAFLD)

[+]

Silymarin may reduce liver fibrosis.Apr 14, 2017

Click here to read the entire abstract

Pubmed Data : Clin Gastroenterol Hepatol. 2017 Apr 15. Epub 2017 Apr 15. PMID: 28419855

Article Published Date : Apr 14, 2017

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Fibrotic

[+]

Silymarin monotherapy can be a therapeutic option for the treatment of acne vulgaris.Oct 02, 2019

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Pubmed Data : Dermatol Ther. 2019 Oct 3:e13095. Epub 2019 Oct 3. PMID: 31579978

Article Published Date : Oct 02, 2019

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Acne

Pharmacological Actions : Antioxidants

[+]

Silymarin plus vitamin E could be beneficial in patients with non-alcoholic fatty liver disease.Jul 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2015 Aug ;19(16):3118-3124. PMID: 26367736

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Substances : Silymarin, Vitamin E

Diseases : Nonalcoholic fatty liver disease (NAFLD)

[+]

Silymarin significantly reduced interleukin-6 levels, sizes of endometrioma lesions, and pain-related symptoms.Oct 19, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2022 Oct 20 ;12(1):17549. Epub 2022 Oct 20. PMID: 36266431

Article Published Date : Oct 19, 2022

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Endometriosis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

Additional Keywords : Significant Treatment Outcome

[+]

Silymarin-phosphatidylserine and galega increased milk production in mothers of preterm infants.Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : Eur J Clin Nutr. 2016 Oct ;70(10):1151-1154. Epub 2016 Jun 1. PMID: 27245206

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Breast Milk: Inadequate/Poor Quality

Pharmacological Actions : Galactogogue

[+]

The combination of iron chelation therapy with silymarin can improve inflammatory status in patients with β-thalassemia major.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : Complement Med Res. 2021 ;28(2):123-130. Epub 2020 Sep 24. PMID: 32971524

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Inflammation, Thalassemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation

[+]

The effect of silymarin on liver enzymes in patients taking isotretinoin.Feb 29, 2020

Click here to read the entire abstract

Pubmed Data : Dermatol Ther. 2020 Mar ;33(2):e13236. Epub 2020 Feb 10. PMID: 31997509

Article Published Date : Feb 29, 2020

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Enzyme Inhibitors, Hepatoprotective

Problem Substances : Isotretinoin

[+]

This study showed a potential antihyperglycemic and triglyceride lowering effect of the herbal formulation.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : J Evid Based Complementary Altern Med. 2017 Jan 1:2156587217696929. Epub 2017 Jan 1. PMID: 29228792

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Nettle, Olibanum, Silymarin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

[+]

Silymarin suppresses cellular inflammation by inducing reparative stress signaling.Aug 27, 2015

Click here to read the entire abstract

Pubmed Data : J Nat Prod. 2015 Aug 28 ;78(8):1990-2000. Epub 2015 Jul 17. PMID: 26186142

Article Published Date : Aug 27, 2015

Study Type : Human In Vitro

Additional Links

Substances : Silymarin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator

[+]

Skin protective activity of silymarin and its flavonolignans.Mar 13, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2019 Mar 14 ;24(6). Epub 2019 Mar 14. PMID: 30875758

Article Published Date : Mar 13, 2019

Study Type : Human In Vitro

Additional Links

Substances : Silymarin

Diseases : Aging Skin, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Photoprotective

[+]

Administration of silymarin significantly prevented acute liver injury induced by restraint stress.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2016 ;21(4). Epub 2016 Apr 1. PMID: 27043523

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Antioxidant actions of thymoquinone, silymarin, and curcumin on experimental aortic ischemia-reperfusion.Jun 02, 2022

Click here to read the entire abstract

Pubmed Data : Braz J Cardiovasc Surg. 2022 Jun 3. Epub 2022 Jun 3. PMID: 35657313

Article Published Date : Jun 02, 2022

Study Type : Animal Study

Additional Links

Substances : Curcumin, Silymarin, Thymoquinone

Diseases : Ischemia

Pharmacological Actions : Antioxidants

[+]

Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(2):e0147745. Epub 2016 Feb 16. PMID: 26881746

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Bisdemethoxycurcumin, Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Comparative study of the protective effects of citral, thymoquinone, and silymarin on methotrexate-induced cardiotoxicity.Sep 29, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacopuncture. 2024 Sep 30 ;27(3):245-252. PMID: 39350925

Article Published Date : Sep 29, 2024

Study Type : Animal Study

Additional Links

Substances : Citral, Silymarin, Thymoquinone

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Cardioprotective

[+]

Comparison of the effects of thymoquinone and silymarin on the brain of rats having ischemia-reperfusion in the lower extremities.Nov 18, 2019

Click here to read the entire abstract

Pubmed Data : Ann Ital Chir. 2019 Nov 19 ;8. Epub 2019 Nov 19. PMID: 31769414

Article Published Date : Nov 18, 2019

Study Type : Animal Study

Additional Links

Substances : Silymarin, Thymoquinone

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

Curcumin, silymarin and N-acetylcysteine protect against antitubercular drug-induced hepatotoxicity. Feb 08, 2012

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2012 Feb 8. Epub 2012 Feb 8. PMID: 22318308

Article Published Date : Feb 08, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, NAC (N-acetyl-L-cysteine), Silymarin

Diseases : Tuberculosis Drug Induced Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Tubercular Drugs

[+]

Effective action of silymarin against ketamine-induced schizophrenia.Sep 11, 2024

Click here to read the entire abstract

Pubmed Data : J Psychiatr Res. 2024 Sep 12 ;179:141-155. Epub 2024 Sep 12. PMID: 39293119

Article Published Date : Sep 11, 2024

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Schizophrenia

Pharmacological Actions : Antipsychotic Agents

[+]

Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity.Jan 06, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Med Ther. 2021 Jan 7 ;21(1):19. Epub 2021 Jan 7. PMID: 33413326

Article Published Date : Jan 06, 2021

Study Type : Animal Study

Additional Links

Substances : Coffee: Green/Unroasted, Silymarin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity.Nov 17, 2019

Click here to read the entire abstract

Pubmed Data : J Immunoassay Immunochem. 2019 Nov 18:1-13. Epub 2019 Nov 18. PMID: 31739724

Article Published Date : Nov 17, 2019

Study Type : Animal Study

Additional Links

Substances : Artichoke, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Gastroenterology Res. 2012 Oct ;5(5):190-194. Epub 2012 Sep 20. PMID: 27785204

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine), Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum-induced oxidative stress, hyperlipidemia, and genotoxicity.May 31, 2024

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2024 Jun ;39(6):3746-3759. Epub 2024 Mar 28. PMID: 38546352

Article Published Date : May 31, 2024

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Aluminum Toxicity , Hyperlipidemia, Kidney Damage: Chemically-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Aluminum Chloride

[+]

Palmitoylethanolamide and silymarin treatment attenuated the degree of renal inflammation.Sep 04, 2015

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2015 Sep 5 ;762:136-49. Epub 2015 May 14. PMID: 25981305

Article Published Date : Sep 04, 2015

Study Type : Animal Study

Additional Links

Substances : Palmitoylethanolamide , Silymarin

Diseases : Ischemia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective

[+]

Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity.Mar 11, 2019

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2019 Mar 12:1-7. Epub 2019 Mar 12. PMID: 30862206

Article Published Date : Mar 11, 2019

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Renoprotective

Problem Substances : Vancomycin

[+]

Pretreatment with silymarin 2 h before cisplatin significantly decreased the pathological changes induced by cisplatin and appeared highly protective.May 14, 2010

Click here to read the entire abstract

Pubmed Data : Pak J Biol Sci. 2010 May 15 ;13(10):463-79. PMID: 21848071

Article Published Date : May 14, 2010

Study Type : Animal Study

Additional Links

Substances : Milk Thistle, Silymarin

Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Chemotherapeutic

[+]

Protective effect of silymarin and gallic acid against cisplatin-induced nephrotoxicity and hepatotoxicity.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Clin Pract. 2022 ;2022:6541026. Epub 2022 Apr 16. PMID: 35685593

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Gallic Acid, Silymarin

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, Renoprotective

[+]

Protective effects of combined β-caryophyllene and silymarin against ketoprofen-induced hepatotoxicity.Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2016 Jul ;94(7):739-44. Epub 2016 Mar 9. PMID: 27124106

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Beta-Caryophyllene, Silymarin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Beta-Caryophyllene, Hepatoprotective, Liver Damage: Drug-Induced, Plant Extracts, SILYMARIN

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity.Sep 04, 2019

Click here to read the entire abstract

Pubmed Data : Gene. 2019 Sep 5 ;712:143966. Epub 2019 Jul 4. PMID: 31279711

Article Published Date : Sep 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance Synergy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Radioprotective effects of Silymarin on the sperm parameters of NMRI mice irradiated with γ-rays.Dec 05, 2017

Click here to read the entire abstract

Pubmed Data : J Photochem Photobiol B. 2017 Dec 6 ;178:489-495. Epub 2017 Dec 6. PMID: 29232573

Article Published Date : Dec 05, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Radioprotective

[+]

Silybin is an effective component of silymarin for treating metabolic syndrome by stimulating FXR signalling.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2016 ;7:345. Epub 2016 Aug 28. PMID: 27733832

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Metabolic Diseases, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic

[+]

Silymarin and melatonin can attenuate renal injury in rats treated with gentamicin.Dec 22, 2015

Click here to read the entire abstract

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26703224

Article Published Date : Dec 22, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin, Silymarin

Diseases : Chemotherapy-Induced Toxicity: Gentamicin

Pharmacological Actions : Malondialdehyde Down-regulation, Renoprotective

[+]

Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers.Feb 14, 2017

Click here to read the entire abstract

Pubmed Data : Pathophysiology. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28254270

Article Published Date : Feb 14, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Aspartame

[+]

Silymarin can significantly reduce anxiety and depression-like symptoms, and neuroinflammation after mild traumatic brain injury.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2018 Jan 1 ;338:159-173. Epub 2017 Nov 22. PMID: 29175455

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Depression, Traumatic Brain Injury

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Fluoxetine (trade name Prozac)

[+]

Silymarin could attenuate hepatic steatosis in a mouse model of NAFLD through regulation of lipid metabolism and oxidative stress.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2016 ;8(2):1073-81. Epub 2016 Feb 15. PMID: 27158393

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD), Oxidative Stress

Pharmacological Actions : Antioxidants, Hypolipidemic

[+]

Silymarin may exert protective effects against paraquat induced lung injury.Jul 13, 2015

Click here to read the entire abstract

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 Jul 14. Epub 2015 Jul 14. PMID: 26173462

Article Published Date : Jul 13, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Oxidative Stress, Pesticide Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

[+]

Silymarin prevents memory impairments, anxiety, and depressive-like symptoms in a model of post-traumatic stress disorder.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Planta Med. 2019 Jan ;85(1):32-40. Epub 2018 Aug 28. PMID: 30153692

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Anxiety, Depression, Post-Traumatic Stress Disorders (PTSD)

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents

[+]

Silymarin showed a dual effect on liver damage induced by irinotecan.Apr 24, 2017

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2017 Apr 25. Epub 2017 Apr 25. PMID: 28454924

Article Published Date : Apr 24, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

Problem Substances : Irinotecan

[+]

Silymarin showed a significant anti-proliferative and pro-apoptotic role in benign prostatic hyperplasia.Jan 03, 2020

Click here to read the entire abstract

Pubmed Data : Pathol Oncol Res. 2020 Jan 4. Epub 2020 Jan 4. PMID: 31902118

Article Published Date : Jan 03, 2020

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Silymarin suppressed lung cancer growth in mice via inhibiting myeloid-derived suppressor cells.Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Jul ;81:460-7. Epub 2016 Apr 29. PMID: 27261626

Article Published Date : Jun 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative

[+]

Silymarin suppresses HepG2 hepatocarcinoma cell progression.Jan 31, 2020

Click here to read the entire abstract

Pubmed Data : Pharmacol Rep. 2020 Feb ;72(1):199-207. Epub 2020 Jan 8. PMID: 32016841

Article Published Date : Jan 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Dose Response

[+]

Silymarin was sufficient to induce a protective effect against structural and ultrastructural injuries induced by BPA.Feb 28, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2017 Mar ;13(3):821-828. Epub 2017 Jan 20. PMID: 28450905

Article Published Date : Feb 28, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Bisphenol A

[+]

Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps.Apr 13, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2020 Apr 14 ;26(14):1601-1612. PMID: 32327909

Article Published Date : Apr 13, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin, Frankincense, Silymarin

Diseases : Intestinal Polyps

Pharmacological Actions : Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Silymarin’s alleviation of inflammatory responses could be responsible for its benefits against liver damage and insulin resistance.Jul 07, 2016

Click here to read the entire abstract

Pubmed Data : Pharm Biol. 2016 Jul 8:1-6. Epub 2016 Jul 8. PMID: 27387273

Article Published Date : Jul 07, 2016

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Insulin Resistance, Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Synergistic effects of citicoline and silymarin nanomicelles in restraint stress-exposed mice.Apr 26, 2024

Click here to read the entire abstract

Pubmed Data : Behav Brain Res. 2024 Apr 27 ;464:114929. Epub 2024 Feb 29. PMID: 38428646

Article Published Date : Apr 26, 2024

Study Type : Animal Study

Additional Links

Substances : Citicoline, Silymarin

Diseases : Anxiety

Pharmacological Actions : Anti-Inflammatory Agents, Brain-derived neurotrophic factor modulator

[+]

Syringic acid and silymarin concurrent administration inhibits sodium valproate-induced liver injury.Aug 31, 2022

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2022 Sep ;37(9):2143-2152. Epub 2022 May 11. PMID: 35543257

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Silymarin, Syringic Acid

Diseases : Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Taurine may be used in combination with silymarin as an additional adjunct therapy to cure liver diseases such as fibrosis, cirrhosis and viral hepatitis.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(12):e0144509. Epub 2015 Dec 11. PMID: 26659465

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Silymarin, Taurine

Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis, Liver Disease, Liver Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

[+]

The antioxidant and hepatoprotective potential of berberine and silymarin on acetaminophen induced toxicity.Jan 23, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Animals (Basel). 2024 Jan 24 ;14(3). Epub 2024 Jan 24. PMID: 38338016

Article Published Date : Jan 23, 2024

Study Type : Animal Study

Additional Links

Substances : Berberine, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

The hydroethanolic extract of Mucuna pruriens leaves possesses hepatoprotective activity.Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Chin J Nat Med. 2014 Apr ;12(4):273-83. PMID: 24863352

Article Published Date : Mar 31, 2014

Study Type : Animal Study

Additional Links

Substances : Mucuna pruriens (aka Velvet Beans), Silymarin

Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Tuberculosis Drug Induced Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

[+]

The results demonstrate that silymarin protects against MPTP-induced changes in autophagy leading to Parkinsonism.Nov 14, 2019

Click here to read the entire abstract

Pubmed Data : J Mol Neurosci. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31732923

Article Published Date : Nov 14, 2019

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behaviour.Nov 30, 2017

Click here to read the entire abstract

Pubmed Data : J Psychopharmacol. 2017 Dec 1:269881117742666. Epub 2017 Dec 1. PMID: 29215318

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator

[+]

These findings suggest that silymarin attenuates the severity of acute pancreatitis.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Pancreas. 2020 Jan ;49(1):89-95. PMID: 31856083

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Pancreatitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Pancreato Protective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

These findings suggest that thymoquinone, silymarin, and N-acetylcysteine have potential for the treatment of diseases causing liver injury.Jul 29, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Jul 30 ;106:1705-1712. Epub 2018 Jul 30. PMID: 30119245

Article Published Date : Jul 29, 2018

Study Type : Animal Study

Additional Links

Substances : Cysteine (see N-Acetylcysteine), Silymarin, Thymoquinone

Diseases : Liver Damage, Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

[+]

This study found that silymarin plays a crucial role in accelerated liver regeneration after partial hepatectomy.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:603529. Epub 2015 Aug 3. PMID: 26339266

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Liver Damage

Pharmacological Actions : Regenerative

[+]

Thymoquinone and silymarin is quite effective in preventing tissue damage in the brain following the ischemia reperfusion.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Ann Ital Chir. 2020 ;91:131-136. PMID: 32180584

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Silymarin, Thymoquinone

Diseases : Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

A number of plant polyphenols have chemosensitizing and radiosensitizing activity. Nov 01, 2005

Click here to read the entire abstract

Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. PMID: 16356126

Article Published Date : Nov 01, 2005

Study Type : Review

Additional Links

Substances : Betulinic acid, Caffeic acid phenethyl ester, Curcumin, Emodin, Flavonoids, Genistein, Green Tea, Polyphenols, Resveratrol, Silymarin, Ursolic Acid

Diseases : Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer, Radiosensitizer

[+]

A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds. Jul 31, 2011

Click here to read the entire abstract

Pubmed Data : Clin J Gastroenterol. 2011 Aug ;4(4):185-97. Epub 2011 Jun 4. PMID: 26189518

Article Published Date : Jul 31, 2011

Study Type : Review

Additional Links

Substances : Caffeine, Capsaicin, Cinnamaldehyde, Curcumin, Diallyl sulfide, EGCG (Epigallocatechin gallate), Genistein, Lycopene, Resveratrol, Silymarin, Sulforaphane, Xanthohumol

Diseases : Liver Cancer

Pharmacological Actions : Chemopreventive

[+]

Antifibrotic effect of silymarin on arecoline-induced fibrosis in primary human buccal fibroblasts.Feb 14, 2024

Click here to read the entire abstract

Pubmed Data : Mol Biol Rep. 2024 Feb 15 ;51(1):303. Epub 2024 Feb 15. PMID: 38356030

Article Published Date : Feb 14, 2024

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antiproliferative

[+]

Antiviral activity of silymarin and baicalein against dengue virus.Oct 26, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2021 Oct 27 ;11(1):21221. Epub 2021 Oct 27. PMID: 34707245

Article Published Date : Oct 26, 2021

Study Type : In Vitro Study

Additional Links

Substances : Baicalein, Silymarin

Diseases : Dengue

Pharmacological Actions : Antiviral Agents

[+]

Antivirals against chikungunya virus: Is the solution in nature?Jan 28, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Viruses. 2020 02 29 ;12(3). Epub 2020 Feb 29. PMID: 32121393

Article Published Date : Jan 28, 2020

Study Type : Review

Additional Links

Substances : Apigenin, Berberine, Chrysin, EGCG (Epigallocatechin gallate), Fisetin, Luteolin, Naringenin , Silibinin, Silymarin, Tannic Acid

Diseases : Chikungunya Virus

Pharmacological Actions : Antiviral Agents

[+]

Beta glucan and silymarin may protect against depleted uranium associated toxicity. Mar 01, 2011

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2011 Mar;30(3):173-81. Epub 2010 Jun 3. PMID: 20522489

Article Published Date : Mar 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Beta-glucan, Silymarin

Diseases : Uranium Poisoning

Pharmacological Actions : Radioprotective

[+]

Combinatorial treatments using phytochemicals are effective against colorectal cancer.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer. 2016 ;7(10):1250-7. Epub 2016 Jun 23. PMID: 27390600

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Silymarin

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Flavolignans from silymarin as Nrf2 bioactivators and their therapeutic applications. May 13, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomedicines. 2020 May 14 ;8(5). Epub 2020 May 14. PMID: 32423098

Article Published Date : May 13, 2020

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2.Mar 29, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytother Res. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33786876

Article Published Date : Mar 29, 2021

Study Type : Review

Additional Links

Substances : Biochanin A, Diosmin , EGCG (Epigallocatechin gallate), Epicatechin, Flavonoids, Genistein, Hesperidin, Luteolin, Naringenin , Quercetin, Rutin, Silymarin

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Storm

[+]

Flavonoids for treating pulmonary fibrosis: Present status and future prospects.Jul 09, 2024

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2024 Jul 10. Epub 2024 Jul 10. PMID: 38986681

Article Published Date : Jul 09, 2024

Study Type : Review

Additional Links

Substances : Baicalein, Citrus naringin, Flavonoids, Kaempferol, Puerarin, Quercetin, Silymarin

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants

[+]

Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2021 Dec ;43(1):351-361. PMID: 33593237

Article Published Date : Nov 30, 2021

Study Type : Review

Additional Links

Substances : Curcumin, Emodin, Quercetin, Resveratrol, Silymarin

Diseases : Chronic Kidney Disease (CKD)

Pharmacological Actions : Antioxidants

[+]

In a pooled analysis of trials in patients with cirrhosis, silymarin treatment was associated with a significant reduction in liver-related deaths.Feb 17, 2020

Click here to read the entire abstract

Pubmed Data : Adv Ther. 2020 Feb 17. Epub 2020 Feb 17. PMID: 32065376

Article Published Date : Feb 17, 2020

Study Type : Review

Additional Links

Substances : Milk Thistle, Silymarin

Diseases : Liver Disease

Pharmacological Actions : Hepatoprotective, Regenerative

Additional Keywords : Liver Regeneration

[+]

Lycopene, 6-gingerol, and silymarin are able to induce apoptosis and reduction of mitochondrial membrane potential in glioblastoma cells.Dec 29, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Dec 30 ;12(1). Epub 2019 Dec 30. PMID: 31905849

Article Published Date : Dec 29, 2019

Study Type : In Vitro Study

Additional Links

Substances : Gingerol , Lycopene, Silymarin

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Natural polyphenols prevent indomethacin-induced and diclofenac-induced Caco-2 cell death.Jan 09, 2020

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31922618

Article Published Date : Jan 09, 2020

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid, Curcumin, EGCG (Epigallocatechin gallate), Gallic Acid, Naringenin , Piperine, Polyphenols, Quercetin, Rutin, Silymarin

Diseases : Drug-Induced Toxicity: Gastrointestinal, Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Antioxidants, Gastroprotective

Problem Substances : Diclofenac, Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Natural substances such as Aloe vera, cinnamon, green tea, fenugreek, and silymarin can be used as a new supportive care for PCOS.Mar 26, 2020

Click here to read the entire abstract

Pubmed Data : Biomol Concepts. 2020 Mar 26 ;11(1):57-75. Epub 2020 Mar 26. PMID: 32229652

Article Published Date : Mar 26, 2020

Study Type : Review

Additional Links

Substances : Aloe Vera, Cinnamon, Fenugreek, Green Tea, Silymarin

Diseases : Polycystic Ovary Syndrome

[+]

Piperine enhances the bioavailability of silybin.Sep 27, 2018

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2018 Sep 28 ;54:98-108. Epub 2018 Sep 28. PMID: 30668388

Article Published Date : Sep 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperine, Silymarin

Additional Keywords : Food Bioavailability Enhancers

[+]

Silibinin is a good sensitizing agent for rhTRAIL-resistant Triple-negative breast cancer.Jan 11, 2017

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2017 12 ;37(12):6593-6599. PMID: 29187434

Article Published Date : Jan 11, 2017

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Breast Cancer: Triple Negative , Cancers: Drug Resistant

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Silymarin ameliorates diabetes-induced proangiogenic response in brain endothelial cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Diabetes Res. 2017 ;2017:2537216. Epub 2017 Oct 25. PMID: 29209632

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Diabetic Complications

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

[+]

Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2015 ;2015:292797. Epub 2015 Mar 11. PMID: 25866771

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Silibinin, Silymarin

Diseases : Candida Albicans, Escherichia coli Infections, Pseudomonas aeruginosa, Staphylococcus aureus infection

Pharmacological Actions : Antimicrobial

Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy

[+]

Silymarin as an antioxidant therapy in chronic liver diseases.Jul 31, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cureus. 2024 Aug ;16(8):e67083. Epub 2024 Aug 17. PMID: 39286715

Article Published Date : Jul 31, 2024

Study Type : Review

Additional Links

Substances : Silymarin

Diseases : Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Silymarin can effectively alleviate acrylamide induced neurotoxicity in PC12 cells.Mar 31, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Apr ;102:93-101. Epub 2017 Jan 27. PMID: 28137608

Article Published Date : Mar 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Acrylamide-induced toxicity

Pharmacological Actions : Antioxidants, Glutathione Upregulation , Malondialdehyde Down-regulation, Neuroprotective Agents, Nrf2 activation

Problem Substances : Acrylamide

[+]

Silymarin encapsulated nanoliquid crystals for improved activity against beta amyloid induced cytotoxicity.Feb 06, 2020

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2020 Feb 7 ;149:1198-1206. Epub 2020 Feb 7. PMID: 32044368

Article Published Date : Feb 06, 2020

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Silymarin exhibited significant in vitro antiviral activity against chikungunya virus.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2015 ;5:11421. Epub 2015 Jun 16. PMID: 26078201

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Chikungunya Virus

Pharmacological Actions : Antiviral Agents

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Silymarin impacts on immune system as an immunomodulator: One key for many locks.Aug 31, 2017

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Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:194-201. Epub 2017 Jun 30. PMID: 28672215

Article Published Date : Aug 31, 2017

Study Type : Review

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Substances : Silymarin

Diseases : Allergies, Autoimmune Diseases, Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, NF-kappaB Inhibitor

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Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells.Oct 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Rep. 2019 Nov ;42(5):1904-1914. Epub 2019 Aug 28. PMID: 31485597

Article Published Date : Oct 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Silymarin inhibited DU145 cells by activating SLIT2 protein and suppressing expression of CXCR4.Feb 14, 2020

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Pubmed Data : Med Oncol. 2020 Feb 15 ;37(3):18. Epub 2020 Feb 15. PMID: 32062757

Article Published Date : Feb 14, 2020

Study Type : In Vitro Study

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Substances : Silymarin

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Silymarin inhibits endothelial progenitor cell aging through telomerase upregulation. Aug 09, 2002

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Pubmed Data : Life Sci. 2002 Aug 9;71(12):1385-96. PMID: 20838231

Article Published Date : Aug 09, 2002

Study Type : In Vitro Study

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Substances : Silymarin

Diseases : Aging

Pharmacological Actions : Telomerase Upregulation

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Silymarin is an ally against insulin resistance: A review.Jun 30, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Hepatol. 2021 Jul-Aug;23:100255. Epub 2020 Sep 17. PMID: 32950646

Article Published Date : Jun 30, 2021

Study Type : Review

Additional Links

Substances : Silymarin

Diseases : Insulin Resistance

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Insulin Sensitizers

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Silymarin restores regulatory T cells (Tregs) function in Multiple sclerosis patients in vitro.Jul 31, 2019

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Pubmed Data : Inflammation. 2019 Aug ;42(4):1203-1214. PMID: 30806958

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Multiple Sclerosis

Pharmacological Actions : Antioxidants, Immunomodulatory

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Silymarin was found to be able to inhibit telomerase activity in HepG2 cells.Feb 28, 2015

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Pubmed Data : J BUON. 2015 Mar-Apr;20(2):555-61. PMID: 26011349

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Milk Thistle, Silymarin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Telomerase Inhibitor

Additional Keywords : Plant Extracts

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Silymarin, a popular dietary supplement shows anti-candida activity.Oct 30, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antibiotics (Basel). 2019 Oct 31 ;8(4). Epub 2019 Oct 31. PMID: 31683548

Article Published Date : Oct 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Candida Albicans, Candida Infection

Pharmacological Actions : Anti-Bacterial Agents

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Silymarin-mediated downregulation of β-catenin and TCF4 may result in the inhibition of Wnt signalling in human colorectal cancer cells.Apr 10, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomol Ther (Seoul). 2016 Apr 11. Epub 2016 Apr 11. PMID: 27068260

Article Published Date : Apr 10, 2016

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Colorectal Cancer

Pharmacological Actions : Wnt/β-catenin signaling pathway modulation

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The objective of this review is to provide information pertaining to various antioxidants found in food that have demonstrated utility in improving liver diseases. Aug 05, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastrointest Pharmacol Ther. 2015 Aug 6 ;6(3):59-72. PMID: 26261734

Article Published Date : Aug 05, 2015

Study Type : Review

Additional Links

Substances : Coffee, Curcumin, Naringenin , Quercetin, Resveratrol, Silymarin

Diseases : Liver Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants

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The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic reviewAug 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2019 Sep ;22(9):968-976. PMID: 31807239

Article Published Date : Aug 31, 2019

Study Type : Review

Additional Links

Substances : Silymarin

Diseases : Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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The treatment of the K562 cells with silymarin resulted in a significant inhibition of cell growth and telomerase activity.May 31, 2012

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Pubmed Data : Planta Med. 2012 Jun ;78(9):899-902. Epub 2012 Apr 24. PMID: 22532022

Article Published Date : May 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Silymarin

Diseases : Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Telomerase Inhibitor

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These natural inhibitors have been shown to block HPV infection and inhibition of HPV oncoproteins. May 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Genomics Inform. 2015 Jun ;13(2):60-7. Epub 2015 Jun 30. PMID: 26175664

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Artemisinin, Berberine, Curcumin, EGCG (Epigallocatechin gallate), Ferulic acid, Gingerol , Indole-3-Carbinol, Resveratrol, Silymarin, Ursolic Acid

Diseases : Human Papillomavirus (HPV)

Pharmacological Actions : Antiviral Agents, Chemopreventive

Additional Keywords : E6 Oncoprotein, Risk Reduction

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This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives,Apr 18, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2019 Apr 19 ;24(8). Epub 2019 Apr 19. PMID: 31010179

Article Published Date : Apr 18, 2019

Study Type : Review

Additional Links

Substances : Silymarin

Diseases : Chikungunya Virus, Dengue, Hepatitis B , Hepatitis C, HIV Infections, Influenza

Pharmacological Actions : Antiviral Agents

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Treatment of melasma: a review of less commonly used antioxidants.Aug 19, 2020

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Pubmed Data : Int J Dermatol. 2020 Aug 20. Epub 2020 Aug 20. PMID: 32815582

Article Published Date : Aug 19, 2020

Study Type : Review

Additional Links

Substances : Ginseng (Korean), Grape Seed Extract, Niacinamide, Parsley, Pycnogenol (Pine Bark), Silymarin, Zinc

Diseases : Melasma

Pharmacological Actions : Antioxidants

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Various plant substances inhibit chemically-induced mammary gland tumor promotion. Mar 01, 2008

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Pubmed Data : Nutr Cancer. 2008 Mar-Apr;60(2):227-34. PMID: 1905902

Article Published Date : Mar 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Beta Sitosterol, Curcumin, D-Limonene, DHEA (Dehydroepiandrosterone), Silymarin

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Chemopreventive

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View the Evidence: 113 Abstracts with Silymarin Research

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The effectiveness of curcumin, resveratrol, and silymarin on MASLD.Nov 30, 2024

Impact of silymarin in individuals with nonalcoholic fatty liver disease.Dec 31, 2020

Silymarin has positive efficacy to reduce transaminases levels in NAFLD patients.Nov 30, 2017

Silymarin supplementation in combination with other treatments had a favorable effect on blood lipids.Mar 04, 2019

Systematic review of the efficacy of herbal galactogogues.Apr 30, 2013

"Protective effect of silymarin during coronary artery bypass grafting surgery."Dec 31, 2011

A silymarin-based cream may be a promising and effective treatment for the prevention of acute skin lesions caused by radiotherapy of breast cancer patients.Aug 01, 2011

Combined iron-chelation and silymarin therapy was effective for improving the iron-burden status in patients with β-thalassemia major.Dec 12, 2017

Efficacy and safety of topical silymarin versus low fluence 1064-nm Q switched Nd:YAG laser in the treatment of melasma.Nov 30, 2021

Evaluation of efficacy of cholecalciferol and silymarin in improving lower urinary tract symptoms of benign prostatic hyperplasia.Sep 01, 2024

Investigating the impact of silymarin on liver oxidative injury.Feb 29, 2020

Oral silibinin, an IGF-1 binder, may result in lowered IGF-1 levels in liver and colorectal cancer patients as indicated by its accumulation in blood and tissue samples. May 01, 2006

Prophylactic administration of conventional form of silymarin tablets could significantly reduce the severity of radiotherapy induced mucositis.Aug 22, 2016

Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients.Sep 22, 2024

Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety.Nov 14, 2016

Silymarin and selenium are safe and effective in reducing two markers of lipid metabolism associated with prostate cancer progression after radical prostatectomy.Sep 01, 2010

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

Silymarin in high dose is a good choice for improvement of liver biochemical profile and QoL in chronic hepatitis C virus cirrhotic patients.Oct 31, 2017

Silymarin in non-cirrhotics with non-alcoholic steatohepatitis.Dec 31, 2018

Silymarin is a potential effective supplementation for reducing toxicities in mCRC patients undergoing first-line FOLFIRI plus bevacizumab.Sep 06, 2021

Silymarin is effective in reduced ALT and AST in NAFLD.Jul 31, 2012

Silymarin may reduce liver fibrosis.Apr 14, 2017

Silymarin monotherapy can be a therapeutic option for the treatment of acne vulgaris.Oct 02, 2019

Silymarin plus vitamin E could be beneficial in patients with non-alcoholic fatty liver disease.Jul 31, 2015

Silymarin significantly reduced interleukin-6 levels, sizes of endometrioma lesions, and pain-related symptoms.Oct 19, 2022

Silymarin-phosphatidylserine and galega increased milk production in mothers of preterm infants.Sep 30, 2016

The combination of iron chelation therapy with silymarin can improve inflammatory status in patients with β-thalassemia major.Dec 31, 2020

The effect of silymarin on liver enzymes in patients taking isotretinoin.Feb 29, 2020

This study showed a potential antihyperglycemic and triglyceride lowering effect of the herbal formulation.Dec 31, 2016

Silymarin suppresses cellular inflammation by inducing reparative stress signaling.Aug 27, 2015

Skin protective activity of silymarin and its flavonolignans.Mar 13, 2019

Administration of silymarin significantly prevented acute liver injury induced by restraint stress.Dec 31, 2015

Antioxidant actions of thymoquinone, silymarin, and curcumin on experimental aortic ischemia-reperfusion.Jun 02, 2022

Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.Dec 31, 2015

Comparative study of the protective effects of citral, thymoquinone, and silymarin on methotrexate-induced cardiotoxicity.Sep 29, 2024

Comparison of the effects of thymoquinone and silymarin on the brain of rats having ischemia-reperfusion in the lower extremities.Nov 18, 2019

Curcumin, silymarin and N-acetylcysteine protect against antitubercular drug-induced hepatotoxicity. Feb 08, 2012

Effective action of silymarin against ketamine-induced schizophrenia.Sep 11, 2024

Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity.Jan 06, 2021

Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity.Nov 17, 2019

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum-induced oxidative stress, hyperlipidemia, and genotoxicity.May 31, 2024

Palmitoylethanolamide and silymarin treatment attenuated the degree of renal inflammation.Sep 04, 2015

Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity.Mar 11, 2019

Pretreatment with silymarin 2 h before cisplatin significantly decreased the pathological changes induced by cisplatin and appeared highly protective.May 14, 2010

Protective effect of silymarin and gallic acid against cisplatin-induced nephrotoxicity and hepatotoxicity.Dec 31, 2021

Protective effects of combined β-caryophyllene and silymarin against ketoprofen-induced hepatotoxicity.Jun 30, 2016

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity.Sep 04, 2019

Radioprotective effects of Silymarin on the sperm parameters of NMRI mice irradiated with γ-rays.Dec 05, 2017

Silybin is an effective component of silymarin for treating metabolic syndrome by stimulating FXR signalling.Dec 31, 2015

Silymarin and melatonin can attenuate renal injury in rats treated with gentamicin.Dec 22, 2015

Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers.Feb 14, 2017

Silymarin can significantly reduce anxiety and depression-like symptoms, and neuroinflammation after mild traumatic brain injury.Dec 31, 2017

Silymarin could attenuate hepatic steatosis in a mouse model of NAFLD through regulation of lipid metabolism and oxidative stress.Dec 31, 2015

Silymarin may exert protective effects against paraquat induced lung injury.Jul 13, 2015

Silymarin prevents memory impairments, anxiety, and depressive-like symptoms in a model of post-traumatic stress disorder.Dec 31, 2018

Silymarin showed a dual effect on liver damage induced by irinotecan.Apr 24, 2017

Silymarin showed a significant anti-proliferative and pro-apoptotic role in benign prostatic hyperplasia.Jan 03, 2020

Silymarin suppressed lung cancer growth in mice via inhibiting myeloid-derived suppressor cells.Jun 30, 2016

Silymarin suppresses HepG2 hepatocarcinoma cell progression.Jan 31, 2020

Silymarin was sufficient to induce a protective effect against structural and ultrastructural injuries induced by BPA.Feb 28, 2017

Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps.Apr 13, 2020

Silymarin’s alleviation of inflammatory responses could be responsible for its benefits against liver damage and insulin resistance.Jul 07, 2016

Synergistic effects of citicoline and silymarin nanomicelles in restraint stress-exposed mice.Apr 26, 2024

Syringic acid and silymarin concurrent administration inhibits sodium valproate-induced liver injury.Aug 31, 2022

Taurine may be used in combination with silymarin as an additional adjunct therapy to cure liver diseases such as fibrosis, cirrhosis and viral hepatitis.Dec 31, 2014

The antioxidant and hepatoprotective potential of berberine and silymarin on acetaminophen induced toxicity.Jan 23, 2024

The hydroethanolic extract of Mucuna pruriens leaves possesses hepatoprotective activity.Mar 31, 2014

The results demonstrate that silymarin protects against MPTP-induced changes in autophagy leading to Parkinsonism.Nov 14, 2019

Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behaviour.Nov 30, 2017

These findings suggest that silymarin attenuates the severity of acute pancreatitis.Dec 31, 2019

These findings suggest that thymoquinone, silymarin, and N-acetylcysteine have potential for the treatment of diseases causing liver injury.Jul 29, 2018

Silymarin

View the Evidence:
113 Abstracts with Silymarin Research