Sinomenine

Name	AC	CK
Inflammation	19	33
Rheumatoid Arthritis	12	30
Oxidative Stress	13	25
Arthritis	8	22
Diabetic Nephropathy	3	22
Spondylitis: Ankylosing	2	22
Lipopolysaccharide-Induced Toxicity	8	11
Arthritis: Rheumatoid	1	10
Lung Cancer	6	9
Neuropathic Pain	4	8
Colitis	4	6
Lung Injury: Acute	3	6
Atherosclerosis	3	5
Breast Cancer	4	5
Cardiac Hypertrophy	2	5
Cardiomegaly	2	5
Degenerative Disk Disease	2	5
Ulcerative Colitis	3	5
Acetaminophen (Tylenol) Toxicity	2	4
Brain Injury: Traumatic	2	4
Depression	2	4
Liver Cancer	3	4
Liver Damage: Drug-Induced	2	4
Liver Injury: Ischemia/reperfusion	2	4
Morphine Tolerance/Dependence	2	4
Myocardial Ischemia	2	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Sepsis	2	4
Spinal Cord Injuries	2	4
Alzheimer's Disease	2	3
Brain Inflammation	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Glioblastoma	2	3
Hypoxia	2	3
Multiple Sclerosis	2	3
Osteoarthritis	2	3
Allergic Rhinitis	1	2
Atopic Dermatitis	1	2
Bone Cancer	1	2
Brain: Oxidative Stress	1	2
Cancer: Pain	1	2
Colorectal Cancer	1	2
Dermatitis	1	2
Diabetes Mellitus: Type 2	1	2
Diabetes: Cognitive Dysfunction	1	2
Dry Eye Syndromes	1	2
Endometriosis	1	2
Endotoxemia	1	2
Epilepsy	1	2
Escherichia coli Infections	1	2
Gastric Cancer	2	2
Gestational Diabetes	1	2
High Fat Diet	1	2
Hyperalgesia	1	2
Neurodegenerative Diseases	1	2
Ovarian Cancer	2	2
Parkinson's Disease	1	2
Psoriasis	1	2
Pulmonary Fibrosis	1	2
Sciatica	1	2
Stroke: Ischemic	1	2
Subarachnoid hemorrhage	1	2
Thyroid Cancer	2	2
Wound Healing	1	2
Asthma	1	1
Bladder Cancer	1	1
Cancer Metastasis	1	1
Cancers: All	1	1
Cancers: Drug Resistant	1	1
Cardiac Arrhythmias	1	1
Cardiovascular Diseases	1	1
Cervical Cancer	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Chronic Pain	1	1
Colon Cancer	1	1
Esophageal Cancer	1	1
Glioma	1	1
Heart Failure	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hypertension	1	1
IgA Nephropathy	1	1
Kidney Cancer	1	1
Kidney Fibrosis	1	1
Leukemia	1	1
Lung Damage	1	1
Lymphoma	1	1
Mastitis	1	1
Melanoma	1	1
Pneumonia	1	1
Prostate Cancer	1	1
Prostatic Hyperplasia: Benign	1	1
Retinoblastoma	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1

Name	AC	CK
Anti-Inflammatory Agents	56	129
Tumor Necrosis Factor (TNF) Alpha Inhibitor	19	60
Interleukin-1 beta downregulation	19	59
Antioxidants	24	47
Interleukin-6 Downregulation	17	45
Antiproliferative	28	34
NF-kappaB Inhibitor	18	32
Nrf2 activation	11	24
Apoptotic	18	20
Neuroprotective Agents	11	20
Analgesics	6	11
Anti-Apoptotic	7	10
Cardioprotective	5	10
Interleukin-1 alpha downregulation	1	10
Interleukin-12 downregulation	1	10
Anti-metastatic	7	8
Heme oxygenase-1 up-regulation	4	8
Anti-Fibrotic	4	6
Antineoplastic Agents	4	6
Hepatoprotective	3	6
Anticonvulsants	2	4
Antidepressive Agents	2	4
Chemotherapeutic	3	4
Gastrointestinal Agents	2	4
Malondialdehyde Down-regulation	2	4
Superoxide Dismutase Up-regulation	2	4
Autophagy Up-regulation	2	3
Chemoprotective Agents	2	3
Chemosensitizer	3	3
Immunomodulatory	2	3
Interleukin-8 downregulation	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	3
MicroRNA modulator	3	3
Postaglandin PGE2 downregulation	2	3
Radiosensitizer	3	3
Renoprotective	3	3
Anti-Angiogenic	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Bcl-2 protein down-regulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Cell cycle arrest	2	2
Cyclin D1 Down-Regulation	1	2
Cyclooxygenase 2 Inhibitors	1	2
Immunosuppressive Agents	1	2
Interleukin-10 upregulation	1	2
Interleukin-4 downregulation	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Osteoprotective	1	2
Protein Kinase Inhibitors	1	2
Transforming growth factor beta (TGF-β) upregulation	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Anti-Bacterial Agents	1	1
Bax/Bcl2 Ratio: Decrease	1	1
Chemopreventive	1	1
Hypolipidemic	1	1
Interleukin-18 down-regulation	1	1
P21 Activation	1	1
Wnt/β-catenin signaling pathway modulation	1	1

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Efficacy and safety of sinomenine for diabetic kidney diseases.Dec 28, 2023

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Pubmed Data : Curr Issues Mol Biol. 2024 Jan 21 ;46(1):923-933. Epub 2024 Jan 21. PMID: 38275673

Article Published Date : Jan 20, 2024

Study Type : Animal Study

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Substances : Sinomenine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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High-dose sinomenine attenuates ischemia/reperfusion-induced hepatic inflammation and oxidative stress.May 31, 2024

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Pubmed Data : Exp Ther Med. 2021 Jun ;21(6):647. Epub 2021 Apr 18. PMID: 33968178

Article Published Date : May 31, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Sinomenine

Diseases : Stroke: Ischemic

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation

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Sinomenine alleviates dextran sulfate sodium‑induced colitis.Sep 30, 2018

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Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2023 Aug ;39(8):721-728. PMID: 37515339

Article Published Date : Jul 31, 2023

Study Type : Animal Study

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Substances : Sinomenine

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

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Sinomenine ameliorates bleomycin-induced pulmonary fibrosis.Jul 14, 2024

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Pubmed Data : Molecules. 2018 Sep 17 ;23(9). Epub 2018 Sep 17. PMID: 30227624

Article Published Date : Sep 16, 2018

Study Type : Animal Study

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Substances : Sinomenine

Diseases : Morphine Tolerance/Dependence

Additional Keywords : Exosomes

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Sinomenine protects bone from destruction to ameliorate arthritis.Feb 28, 2021

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Pubmed Data : Food Sci Biotechnol. 2023 Jan ;32(1):83-90. Epub 2022 Sep 21. PMID: 36606087

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Pubmed Data : Neuromolecular Med. 2023 Dec ;25(4):545-562. Epub 2023 Sep 21. PMID: 37735290

Article Published Date : Nov 30, 2023

Study Type : In Vitro Study

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Substances : Sinomenine

Diseases : Multiple Sclerosis, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis.Jun 30, 2023

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Pubmed Data : J Chemother. 2023 Jul ;35(4):357-366. Epub 2022 Sep 19. PMID: 36120905

Sinomenine hydrochloride can ameliorate benign prostatic hyperplasia.Jan 12, 2023

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Pubmed Data : Molecules. 2023 Jan 13 ;28(2). Epub 2023 Jan 13. PMID: 36677863

Article Published Date : Jan 12, 2023

Study Type : In Vitro Study

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Substances : Sinomenine

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

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Sinomenine hydrochloride exerts antitumor outcome in ovarian cancer cells by inhibition of long non-coding RNA HOST2 expression.Nov 30, 2019

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Pubmed Data : Int J Mol Sci. 2018 Mar 14 ;19(3). Epub 2018 Mar 14. PMID: 29538296

Article Published Date : Mar 13, 2018

Study Type : In Vitro Study

Additional Links

Substances : Sinomenine

Diseases : Glioblastoma

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Sinomenine hydrochloride inhibits the progression of plasma cell mastitis.Mar 31, 2020

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Pubmed Data : Int Immunopharmacol. 2020 Apr ;81:106025. Epub 2019 Dec 4. PMID: 31810886

Article Published Date : Mar 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Sinomenine

Diseases : Mastitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Sinomenine hydrochloride promotes TSHR-dependent redifferentiation in papillary thyroid cancer. Sep 13, 2022

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Pubmed Data : Transl Cancer Res. 2023 Sep 30 ;12(9):2393-2404. Epub 2023 Aug 15. PMID: 37859743

Article Published Date : Sep 29, 2023

Study Type : Review

Additional Links

Substances : Sinomenine

Diseases : Cancers: All

Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer, Radiosensitizer

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The pro-apoptosis effect of sinomenine in renal carcinoma.Dec 31, 2017

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Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:1269-1274. Epub 2017 Nov 14. PMID: 29145153

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Sinomenine

Diseases : Kidney Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation

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View the Evidence: 125 Abstracts with Sinomenine Research

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Efficacy and safety of sinomenine for diabetic kidney diseases.Dec 28, 2023

Efficacy and safety of sinomenine preparation for ankylosing spondylitis.Dec 31, 2019

Effects of sinomenine on the proliferation, cytokine production, and regulatory T-cell frequency in peripheral blood mononuclear cells of rheumatoid arthritis patients.Mar 31, 2021

Sinomenine inhibits the progression of rheumatoid arthritis.Dec 31, 2017

Sinomenine alleviates diabetic peripheral neuropathic pain.Feb 28, 2023

Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway.Nov 30, 2021

Sinomenine ameliorates IL-1β-induced intervertebral disc degeneration.Dec 31, 2022

Acupoint application of sinomenine at ST 36 has potential for use in patients with RA by enabling enhanced and prolonged treatment effects.Dec 31, 2018

Anti-depressant-like effect of sinomenine on chronic unpredictable mild stress-induced depression.Oct 25, 2018

Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury.May 31, 2022

Cognitive protection of sinomenine in type 2 diabetes mellitus.Jul 31, 2023

Combing sinomenine and gabapentin or ligustrazine hydrochloride could be highly beneficial in neuropathic pain therapies.Jul 04, 2019

Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury.Jan 09, 2020

Effect of sinomenine on the morphine-dependence and related neural mechanisms in mice.Nov 30, 2017

Effects of sinomenine on a rat orthotopic liver carcinoma model.May 31, 2024

Evaluation of the reparative effect of sinomenine in an acetaminophen-induced liver injury model.Jan 20, 2024

High-dose sinomenine attenuates ischemia/reperfusion-induced hepatic inflammation and oxidative stress.May 31, 2024

Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer.Mar 14, 2024

Immunosuppressive effect of sinomenine in an allergic rhinitis mouse model.Apr 30, 2017

Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor.Dec 31, 2020

Investigating the therapeutic potential of sinomenine in rheumatoid arthritis: anti-inflammatory, antioxidant, and immunomodulatory mechanisms.May 31, 2024

Multifunctional nanoparticles of sinomenine hydrochloride for treat-to-target therapy of rheumatoid arthritis.Jul 31, 2022

Network pharmacology-based approach to explore the underlying mechanism of sinomenine on sepsis-induced myocardial injury.Dec 31, 2022

Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy.Jan 09, 2020

Protective effect of sinomenine against inflammation and oxidative stress in gestational diabetes mellitus.Oct 31, 2021

Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice.Aug 31, 2021

Protective effects of sinomenine against ankylosing spondylitis.May 30, 2018

Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis.May 31, 2024

Protective effects of sinomenine against LPS-induced inflammation.Aug 31, 2017

Repeated sinomenine administration alleviates chronic neuropathic pain-like behaviours.Sep 30, 2014

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways.Jan 14, 2024

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke.May 31, 2021

Sinomenine alleviates dextran sulfate sodium‑induced colitis.Sep 30, 2018

Sinomenine alleviates mechanical hypersensitivity in mice with experimentally induced rheumatoid arthritis.Mar 31, 2015

Sinomenine alleviates murine experimental autoimmune encephalomyelitis model of multiple sclerosis.Jan 31, 2021

Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis.Mar 08, 2023

Sinomenine ameliorates bleomycin A5-induced pulmonary fibrosis.Jul 31, 2023

Sinomenine ameliorates bleomycin-induced pulmonary fibrosis.Jul 14, 2024

Sinomenine ameliorates collagen-induced arthritis.Nov 30, 2023

Sinomenine ameliorates intervertebral disc degeneration.Dec 31, 2018

Sinomenine ameliorates rheumatoid arthritis.Jul 29, 2023

Sinomenine ameliorates septic acute lung injury.Dec 04, 2021

Sinomenine attenuated dextran sulfate sodium-induced inflammatory responses.Feb 28, 2023

Sinomenine attenuates acetaminophen-induced acute liver injury. Dec 31, 2019

Sinomenine attenuates cancer-induced bone pain.Dec 31, 2017

Sinomenine attenuates chronic intermittent hypoxia-induced lung injury.Mar 16, 2018

Sinomenine attenuates septic-associated lung injury through the Nrf2-Keap1 and autophagy.Jan 31, 2020

Sinomenine attenuates traumatic spinal cord injury.Mar 31, 2019

Sinomenine can inhibit the production and activity of TNF-alpha and NF-kappaB to suppress the adhesion, implantation, infiltration and growth of the endometrial cells in the rat model of endometriosis.Aug 01, 2010

Sinomenine confers protection against myocardial ischemia reperfusion injury.Dec 31, 2021

Sinomenine effectively regulated CAP to suppress the activation of TLR4/NF-κB and protect the homeostasis in brain.Jan 31, 2024

Sinomenine exerts a neuroprotective effect on Parkinson's disease.May 31, 2024

Sinomenine exerts anticonvulsant and neuroprotective activity in pentylenetetrazole kindling model of epilepsy.May 17, 2018

Sinomenine exerts antidepressant effects in mice by promoting the hippocampal BDNF signaling pathway.Dec 31, 2017

Sinomenine hydrochloride ameliorates dextran sulfate sodium-induced colitis.Oct 31, 2021

Sinomenine hydrochloride bidirectionally inhibits progression of tumor and autoimmune diseases by regulating AMPK pathway.May 31, 2023

Sinomenine hydrochloride effectively suppressed glioblastoma growth without exhibiting significant toxicity.Sep 10, 2017

Sinomenine hydrochloride-loaded liposomes-in-hydrogel system could effectively inhibit atopic dermatitis.Jul 11, 2024

Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis.Apr 30, 2019

Sinomenine pretreatment alleviates hepatic ischemia/reperfusion injury.Sep 30, 2022

Sinomenine protects against atherosclerosis.Mar 31, 2024

Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-κB pathway.Oct 31, 2018

Sinomenine protects against early brain injury.Apr 24, 2023

Sinomenine protects against morphine dependence.Sep 16, 2018

Sinomenine protects bone from destruction to ameliorate arthritis.Feb 28, 2021

Sinomenine reduces growth and metastasis of breast cancer cells and improves the survival of tumor-bearing mice.Jan 31, 2018

Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury.Dec 31, 2017

Sinomenine suppress the vitamin D3 and high fat induced atherosclerosis.Dec 31, 2020

Sinomenine suppressed keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis.Dec 31, 2021

The data indicate that sinomenine had a protective role in inflammatory pain.Apr 04, 2018

The effect of sinomenine eye drops on experimental dry eye.Nov 30, 2020

These results suggest a new use for sinomenine in the treatment of osteoarthritis.Sep 30, 2019

Sinomenine

View the Evidence:
125 Abstracts with Sinomenine Research