Soy

Name	AC	CK
Breast Cancer	52	202
Prostate Cancer	34	145
Postmenopausal Disorders	16	127
Osteoporosis	20	120
Diabetes Mellitus: Type 2	13	81
Endothelial Dysfunction	9	81
Aging Skin	10	68
Lung Cancer	11	68
Hypothyroidism	4	64
C-Reactive Protein	7	62
Hypertension	10	60
Inflammation	15	56
Coronary Artery Disease	3	52
Osteopenia	9	50
Prostate: PSA Doubling	5	50
Insulin Resistance	11	49
Cardiovascular Diseases	10	48
Obesity	18	47
Cardiac Mortality	2	42
Alzheimer's Disease	21	40
Hyperlipidemia	4	40
Ovarian Cancer	9	39
Breast Cancer: Prevention	7	38
Cancers: All	13	33
Cholesterol: Oxidation	3	31
Endometrial Cancer	4	31
Hot Flash	4	31
Hemodialysis	2	30
Metabolic Syndrome X	6	30
Oxidative Stress	16	30
Prostate Cancer: Prevention	3	30
Proteinuria	3	30
Colon Cancer	14	29
Cancers: Drug Resistant	6	25
Menopausal Syndrome	5	25
Asthma	4	24
Depression	4	23
Estrogen Dominance	5	23
Diabetes: Cardiovascular Illness	3	22
Fatty Liver	5	21
Prostatic Hyperplasia: Benign	2	21
Allergic Rhinitis	2	20
Depression: Postmenopausal	2	20
Gluten Sensitivity	1	20
Kidney Transplant	2	20
Lower Urinary Tract Symptoms	1	20
Non-Small-Cell Lung Carcinoma	1	20
Osteoarthritis	9	20
Osteoarthritis: Hip	2	20
Postmenopausal Complications	1	20
Sexual Development: Dysfunctions and Abnormalities	2	20
Aging	6	19
Nonalcoholic fatty liver disease (NAFLD)	6	19
Estrogen Deficiency	5	17
Liver Cancer	15	17
Radiation Induced Illness	5	17
Androgen-Induced Diseases	3	14
High Cholesterol	2	14
High Fat Diet	7	14
Abdominal Obesity (Midsection Fat)	3	13
Adiponectin: Low Levels	3	13
Pancreatic Cancer	11	13
Psoriasis	3	13
Bone Fractures	2	12
Cervical Cancer	10	12
Colorectal Cancer	3	12
Endotoxemia	2	12
Fibroids: Uterine	3	12
Hepatic Steatosis	3	12
Infertility: Male	2	12
Myocardial Infarction	2	12
Osteoarthritis: Knee	2	12
Perimenopausal Syndrome	2	12
Prenatal Nutrition	2	12
Rotavirus Infections	3	12
Brain Inflammation	6	11
Breast Cancer: Triple Negative	6	11
Chronic Obstructive Pulmonary Disease	2	11
Lipopolysaccharide-Induced Toxicity	8	11
Periodontal Diseases	2	11
Skin Diseases: Photo-Aging	2	11
Thrombosis	2	11
Acute Myeloid Leukemia	1	10
Acute lymphoblastic leukemia (ALL)	1	10
Addison's Disease	1	10
Aneurysm	1	10
Aneurysm: Cerebral	1	10
Athletic Performance	1	10
Atrophic Vaginitis (Vaginal Atrophy)	1	10
COPD	1	10
Cerebral Aneurysm	1	10
Chemotherapy Induced Myelotoxicity	1	10
Cognitive Decline/Dysfunction	5	10
Colorectal Cancer: Prevention	1	10
Diabetes Mellitus: Type 2: Prevention	1	10
Diabetic Complications	6	10
Dry Skin	1	10
Endocrine Cancer	1	10
Estradiol: Too High	1	10
Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios	1	10
Fibrocystic Breast Disease	1	10
Gastroesophageal Reflux	1	10
Heart Rate Variability: Increased	1	10
Hip Fracture	1	10
Hormone Imbalances	1	10
Hypercholesterolemia	1	10
Hyperglycemia	5	10
Infant Infections	1	10
Ischemic Heart Disease	1	10
Liver: Fatty	1	10
Memory Loss	1	10
Menarche: Early Onset	1	10
Multiple Myeloma: Prevention	1	10
Neurodegenerative Diseases	7	10
Organ Transplantation: Kidney	1	10
Overweight	1	10
Premenstrual syndrome	1	10
Prostatic intraepithelial neoplasia (PIN)	1	10
Sarcopenia	1	10
Stroke: Prevention	1	10
Testosterone: Too High	1	10
Urogenital Symptoms	1	10
Vaginal Atrophy	1	10
Vaginal Diseases	1	10
Vaginal Dryness	1	10
Weight Probems: Appetite	1	10
Bladder Cancer	6	8
Chemically-Induced Liver Damage	3	8
Prenatal Nutrition: Health of the Offspring	3	8
Arteriosclerosis	4	7
Chemotherapy-Induced Toxicity: Cisplatin	3	7
Cystic Fibrosis	7	7
Ischemia	4	7
Kidney Diseases	4	7
Cancer Metastasis	5	6
Melanoma	5	6
Memory Impairment: Hormone Deficiency Induced	3	6
Seizures	2	6
Glioblastoma	4	5
Hyperpigmentation	1	5
Parkinson's Disease	3	5
Advanced Glycation End products (AGE)	3	4
Aging: Immunosenecence	2	4
Alcohol Toxicity	2	4
Autoimmune Diseases	2	4
Cerebral Ischemia	2	4
Cholesterol: High	1	4
Colitis	2	4
Coronavirus Infection	3	4
Corticosteroid-Induced Toxicity	2	4
Diabetic Nephropathy	3	4
Inflammatory Bowel Diseases	2	4
Intima Media Thickening	2	4
Learning disorders	2	4
Liver Damage	2	4
Liver Disease	1	4
Low Testosterone	2	4
Lupus Erythematosus: Systemic	2	4
Neurotoxicity	1	4
Osteoporosis: Male	2	4
Ovariectomy Associated Adverse Changes	2	4
Overactive Bladder	1	4
Polycystic Ovary Syndrome	2	4
Prostatitis: Acute	1	4
Prostatitis: Chronic	1	4
Pulmonary Hypertension	2	4
Rheumatoid Arthritis	4	4
Triglycerides: Elevated	1	4
Wound Healing	3	4
Alcoholic Liver Disease	2	3
Arenaviral Hemorrhagic Fever	2	3
Atherosclerosis	2	3
Bisphenol-A Toxicity	2	3
Breast Cancer: Chemically-Induced	2	3
Chemotherapy-Induced Toxicity: Doxorubicin	2	3
Congenital Hypothyroidism	1	3
DNA damage	3	3
Diabetes Mellitus: Type 1	2	3
Endometriosis	2	3
Glioma	3	3
HIV Infections	3	3
Human Papillomavirus (HPV)	2	3
Hypoxia	2	3
Kidney Cancer	2	3
Liver Cancer: Metastatic	2	3
Lymphoma	3	3
Mucopolysaccharidoses	2	3
Multiple Sclerosis	2	3
Neuroblastoma	3	3
Osteonecrosis	2	3
Squamous cell carcinoma	2	3
Thyroid Cancer	2	3
Ultraviolet Radiation Induced Damage	1	3
Acetaminophen (Tylenol) Toxicity	1	2
Acrylamide-induced toxicity	1	2
Allergies	1	2
Amyotrophic Lateral Sclerosis	1	2
Amyotrophic lateral sclerosis (ALS)	1	2
Androgen Deficiency	1	2
Arterial Plaque	1	2
Asthma: Bronchial	1	2
Atopic Dermatitis	1	2
B-cell prolymphocytic leukemia (B-PLL)	1	2
BRCA1/BRCA2: Prevalence	1	2
Bisphenol Toxicity	1	2
Brain Edema	1	2
Brain Ischemia	1	2
Breast Cancer: Metastatic	1	2
Burns	1	2
Cancer Stem Cells	2	2
Cancers: Multi-Drug Resistant	2	2
Cardiomyopathy	1	2
Clostridium Infections	1	2
Colon Cancer: Prevention	1	2
Coronavirus Disease (Covid-19)	1	2
Cortisone Toxicity	1	2
Dementia	1	2
Diabetes	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetes: Eye Disease	1	2
Diabetic Neuropathies	1	2
Diabetic Retinopathy	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Dyslipidemias	1	2
Encephalomyelitis	1	2
Escherichia coli Infections	1	2
Esophageal Cancer	1	2
Gallbladder Cancer	2	2
Gastric Ulcer	1	2
Gastrointestinal Inflammation	1	2
Heart Disease	1	2
Heart Failure	1	2
Hemorrhagic Fevers: Viral	1	2
Hepatoma	1	2
High Cortisol	1	2
High Fructose Diet	1	2
High Sugar Diet	1	2
Hormone Replacement Therapy	1	2
Hyperalgesia	1	2
Hypermethioninemia	1	2
Incontinence: Urinary	1	2
Infant Nutrition	1	2
Infertility: Aging Associated	1	2
Infertility: Female	1	2
Kidney Damage	1	2
Lead Poisoning	1	2
Leiomyoma	2	2
Leukemia: B-Cell	1	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	2
Lipid Peroxidation	1	2
Liver Cirrhosis	1	2
Liver Damage: Drug-Induced	1	2
Liver Fibrosis	1	2
Low DHEA	1	2
Lupus Nephritis	1	2
Malaria	1	2
Mitochondrial Dysfunction	1	2
Muscle Atrophy	1	2
Nicotine/Tobacco Toxicity	1	2
Obsessive-Compulsive Disorder	1	2
Osteomyelitis	1	2
Osteoporosis: Inflammation Induced	1	2
Osteoporosis: Steroid-Induced	1	2
Osteosarcoma	2	2
Pancreatitis	1	2
Phthalate Toxicity	1	2
Polycystic Kidney Diseases	1	2
Portacaval Shunt	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postmenopausal Disorders: Weight Gain/Obesity	1	2
Prediabetes	1	2
Prenatal Chemical Exposures	1	2
Radiation Induced Illness: Thoracic	1	2
Right Ventricular Hypertrophy	1	2
Sanfilippo Syndrome	1	2
Schistosomiasis	1	2
Sciatica	1	2
Septic Shock	1	2
Shock: Septic	1	2
Skin Cancer	2	2
Sleep Disorders	1	2
Spinal Cord Injuries	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	2
Steroid-Induced Toxicity	1	2
Stroke	1	2
Stroke: Attenuation/Recovery	1	2
Stroke: Ischemic	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Traumatic Brain Injury	1	2
Tumors	1	2
Ulcerative Colitis	1	2
Urinary Tract Cancer	1	2
5alpha-dihydrotestosterone (DHT): Elevated Levels/Activity	1	1
Adenoviridae Infections	1	1
Aluminum Toxicity	1	1
Anxiety	1	1
Aortic Stenosis	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Brain: Microglial Activation	1	1
Breast Cancer: BRCA1	1	1
Breast Cancer: Estrogen	1	1
Breast Cancer: estrogen receptor alpha-positive	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cytomegalovirus Infections	1	1
Degenerative Disk Disease	1	1
Diabetes: Cataract	1	1
Diabetes: Glycation/A1C	1	1
Dialysis: Renal	1	1
Dysbiosis	1	1
Ebola Virus Infections	1	1
Fibroid Tumor	1	1
Fluoride Toxicity	1	1
Glioblastoma Multiforme	1	1
HIV Drug-Induced Toxicity	1	1
HSV-1	1	1
HSV-2	1	1
Head and Neck Cancer	1	1
Hemorrhagic Shock	1	1
Herpes Simplex Virus Type 2	1	1
Intestinal Permeability	1	1
Iron Overload	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leukemia	1	1
Lymphoma: Burkitt	1	1
Mastocytoma	1	1
Memory Disorders	1	1
Multiple Myeloma	1	1
Myocardial Ischemia	1	1
Myocarditis	1	1
Nanoparticle Toxicity: Polystyrene	1	1
Nasopharyngeal Cancer	1	1
Ovarian Cancer: Estrogen Induced	1	1
Pesticide Toxicity	1	1
Pituitary Tumours	1	1
Radiation Induced Toxicity: Polonium-120	1	1
Radiation-Induced Illness: Radioiodine (Iodine-131)	1	1
Radiotherapy	1	1
Retinoblastoma	1	1
Salivary Gland Adenoid Cystic Carcinoma.	1	1
Salivary Gland Diseases	1	1
Smoking	1	1
Staphylococcal Infections	1	1
Stomach Cancer	1	1
Testicular Cancer	1	1
Vascular Calcification	1	1

Name	AC	CK
Chemopreventive	55	350
Antioxidants	59	160
Anti-Inflammatory Agents	56	123
Apoptotic	73	115
Antiproliferative	71	101
Neuroprotective Agents	44	87
Tumor Necrosis Factor (TNF) Alpha Inhibitor	20	84
Hypoglycemic Agents	12	56
Interleukin-6 Downregulation	19	56
NF-kappaB Inhibitor	25	52
Antineoplastic Agents	14	50
Anticarcinogenic Agents	18	44
Cell cycle arrest	21	40
Cardioprotective	14	39
Anti-Apoptotic	19	35
Gastrointestinal Agents	7	29
Hepatoprotective	15	28
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	28
Osteoprotective	7	28
Chemosensitizer	15	24
Antidepressive Agents	3	22
Antiviral Agents	11	22
Malondialdehyde Down-regulation	3	22
Vascular Cell Adhesion Molecule-1 Inhibitor	3	22
Gastroprotective	5	18
Hypolipidemic	6	18
MicroRNA modulator	12	17
Chemotherapeutic	12	16
Enzyme Inhibitors	5	16
Anti-metastatic	13	15
Anticholesteremic Agents	3	15
Insulin Sensitizers	4	15
Nrf2 activation	10	15
Vasodilator Agents	3	14
Immunomodulatory	9	13
Insulin-Like Growth Factor Inhibition/Downregulation	3	13
Renoprotective	6	13
Antihypertensive Agents	3	12
Estrogen Receptor Modulators	3	12
Hypotensive	2	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	12
Angiogenesis Inhibitors	7	11
Interleukin-1 beta downregulation	7	11
Ergogenic	1	10
Interleukin-17 downregulation	1	10
Mitogen-activated protein kinase kinase 4 (MEK4)	1	10
Photoprotective	1	10
Pancreato Protective Agents	5	9
Chemoprotective Agents	3	8
Heme oxygenase-1 up-regulation	5	8
Vascular Endothelial Growth Factor A Inhibitor	4	8
Anti-Fibrotic	4	7
Nitric Oxide Enhancer	2	6
Radioprotective	4	6
Radiosensitizer	6	6
Tumor Suppressor Protein p53 Upregulation	4	5
Anti-Angiogenic	2	4
Cyclooxygenase 2 Inhibitors	4	4
Cytoprotective	2	4
Histone deacetylase inhibitor	3	4
Interleukin-10 downregulation	2	4
Interleukin-8 downregulation	3	4
Nitric Oxide Inhibitor	2	4
Secretagogue	2	4
Vascular Endothelial Growth Factor Inhibitors	3	4
Anti-Adipogenic	3	3
Anti-Anxiety Agents	2	3
Anti-Bacterial Agents	2	3
Anti-Glycation Agents	2	3
Bcl-2 protein down-regulation	2	3
Glucagon Like peptide 1 (GLP-1) Up-regulation	2	3
Insulinotrophic	2	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Wnt/β-catenin signaling pathway modulation	2	3
Acetylcholinesterase Down-Regulation	1	2
Alpha-glucosidase inhibitor	1	2
Analgesics	1	2
Cell Differentiation Inducer	2	2
Cyclin D1 Down-Regulation	2	2
Cyclooxygenase Inhibitors	1	2
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation	1	2
Heme oxygenase-1 inducer	1	2
Interleukin-1 alpha downregulation	2	2
Interleukin-10 upregulation	1	2
Lipoxygenase Inhibitors	1	2
Matrix Metalloproteinase-12 (MMP-12) Inhibitor	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Neocardiogenic	1	2
P21 Activation	2	2
Prophylactic Agents	1	2
Prostaglandin Antagonists	2	2
Protein Kinase Inhibitors	1	2
Regenerative	1	2
SIRT1 Activator	1	2
STAT3 Inhibitor	1	2
Spermatogenic	1	2
Steroidogenesis	1	2
Superoxide Dismutase Up-regulation	1	2
Anti-Androgen	1	1
Anti-thrombotic	1	1
Antimutagenic Agents	1	1
Aromatase Inhibitors	1	1
Bax/Bcl2 ratio: Increase	1	1
Bcl-xL down-regulation	1	1
Cytotoxicity	1	1
Drug synergy	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Fibrinolytic Agents	1	1
Glucose transporter-1 (GLUT1) expression down-regulation	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Interleukin-23 Downregulation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Postaglandin PGE2 downregulation	1	1
Proteasome Inhibitors	1	1
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	1
Tyrosinase inhibitors	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin pathway down-regulation	1	1
anti-inflammatory	1	1
apoptosis	1	1

[+]

High total soy product consumption, especially soymilk and tofu, is associated with lower cancer risk.Mar 27, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2024 Mar 28 ;16(7). Epub 2024 Mar 28. PMID: 38613019

Article Published Date : Mar 27, 2024

Study Type : Meta Analysis, Review

Additional Links

Substances : Soy

Diseases : Cancers: All

Pharmacological Actions : Chemopreventive

[+]

Click here to read the entire abstract

Pubmed Data : Eur Urol. 2005 Dec;48(6):922-30; discussion 930-1. Epub 2005 Oct 17. PMID: 16263208

Article Published Date : Dec 01, 2005

Study Type : Human Study

Additional Links

Substances : Antioxidant formulas, Isoflavones, Lycopene, Milk Thistle, Soy

Diseases : Prostate: PSA Doubling, Prostate Cancer

[+]

A daily supplement of soy protein prevents the increase in subcutaneous and total abdominal fat in postmenopausal women. Dec 01, 2007

Click here to read the entire abstract

Pubmed Data : Fertil Steril. 2007 Dec;88(6):1609-17. Epub 2007 Apr 6. PMID: 17412329

Article Published Date : Dec 01, 2007

Study Type : Human Study

Additional Links

Substances : Isoflavones, Soy Protein

Diseases : Abdominal Obesity (Midsection Fat)

[+]

Click here to read the entire abstract

Pubmed Data : Nutrition. 2006 Feb;22(2):104-13. PMID: 16459222

Click here to read the entire abstract

Pubmed Data : JAMA. 2009 Dec 9;302(22):2437-43. PMID: 19996398

Click here to read the entire abstract

Pubmed Data : Calcif Tissue Int. 2019 Dec ;105(6):573-581. Epub 2019 Sep 5. PMID: 31489467

[+]

Pubmed Data : J Gastroenterol Hepatol. 2007 Nov;22(11):2009-14. PMID: 17914984

[+]

Habitual miso consumption is associated with a low prevalence of sarcopenia in patients with type 2 diabetes.Dec 27, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Dec 28 ;13(1). Epub 2020 Dec 28. PMID: 33379405

Article Published Date : Dec 27, 2020

Study Type : Human Study

Additional Links

Substances : Miso

Diseases : Diabetes Mellitus: Type 2, Sarcopenia

Additional Keywords : Risk Reduction

[+]

[+]

Click here to read the entire abstract

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2007 Feb;53(1):57-62. PMID: 17484381

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Beta-glucan, Isoflavones, Soy

Diseases : Aging Skin

[+]

Regular soy food intake may be associated with a reduced risk of breast cancer, and this effect is more pronounced in premenopausal women.Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2008;60(5):568-76. PMID: 18791919

Pubmed Data : Fertil Steril. 2010 May 1;93(7):2095-104. Epub 2010 Apr 8. PMID: 20378106

Article Published Date : May 01, 2010

Study Type : Human Study

Additional Links

Substances : Isoflavones, Soy

[+]

Safety: soy food consumption lowers estrogen levels in nipple aspirate fluid and serum. Jul 08, 2011

Click here to read the entire abstract

Pubmed Data : Cancer Sci. 2008 Jun;99(6):1202-8. Epub 2008 Apr 21. PMID: 18429954

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2018 Apr 10. Epub 2018 Apr 10. PMID: 29739677

Article Published Date : Apr 09, 2018

Study Type : Human Study

Additional Links

Substances : Isoflavones, Soy

Diseases : Cardiovascular Diseases, Menopausal Syndrome

Pharmacological Actions : Cardioprotective

Additional Keywords : Risk Reduction

[+]

Soy isoflavones may benefit some patients with prostate cancer. Jan 01, 2003

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2003;47(2):111-7. PMID: 15087261

Click here to read the entire abstract

Pubmed Data : Hum Cell. 1999 Dec;12(4):189-96. PMID: 16255781

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2000;36(1):14-8. PMID: 10798211

Article Published Date : Jan 01, 2000

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Estradiol: Too High, Estrogen Dominance, Testosterone: Too High

Additional Keywords : Sex Hormone-Binding Globulin

[+]

Soy products, fiber, phytoestrogens, vegetable and fruist, and seaweed consumption reduce the risk of endomentrial cancer. Aug 15, 1997

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 1997 Aug 15;146(4):294-306. PMID: 9270408

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2023 Sep 23 ;15(19). Epub 2023 Sep 23. PMID: 37836398

Click here to read the entire abstract

Pubmed Data : J Med Food. 2006;9(3):368-72. PMID: 17004900

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones, Soy Protein

Diseases : Cholesterol: Oxidation, Hemodialysis

Pharmacological Actions : Antioxidants

[+]

Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women.Jul 01, 2003

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2003 Jul;78(1):123-30. PMID: 12816781

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653

Article Published Date : Feb 28, 2014

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Depression, Depression: Postmenopausal

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluoxetine (trade name Prozac) , Sertraline

[+]

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653

Article Published Date : Feb 28, 2014

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Depression, Depression: Postmenopausal

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluoxetine (trade name Prozac) , Sertraline

[+]

The consumption of antioxidants, e.g. soy products, tea, fruits and vegetables, reduces the risk for cerebral aneurysm. May 01, 2007

Click here to read the entire abstract

Pubmed Data : Ann Epidemiol. 2007 May;17(5):359-63 PMID: 17462545

Article Published Date : May 01, 2007

Study Type : Human Study

Additional Links

Substances : Fruit: All, Green Tea, Soy, Vegetables: All

Diseases : Aneurysm: Cerebral, Cerebral Aneurysm

[+]

The consumption of cured meat is correlated with higher rates of childhood acute leukemia, whereas the consumption of vegetables and bean-curd food lowers risk. Jan 13, 2009

Click here to read the entire abstract

Pubmed Data : BMC Cancer. 2009 Jan 13;9:15 PMID: 19144145

Article Published Date : Jan 13, 2009

Study Type : Human Study

Additional Links

Substances : Beans: All , Soy, Vegetables: All

Diseases : Acute lymphoblastic leukemia (ALL), Acute Myeloid Leukemia

Pharmacological Actions : Chemopreventive

Additional Keywords : Childhood Leukemia

[+]

The consumption of shallot, garlic, soy food and green tea consumption protects against the risk of multiple myeloma. Jun 04, 2012

Click here to read the entire abstract

Pubmed Data : Cancer Epidemiol. 2012 Jun 4. Epub 2012 Jun 4. PMID: 22673750

Article Published Date : Jun 04, 2012

Study Type : Human Study

Additional Links

Substances : Garlic, Green Tea, Shallot, Soy

Diseases : Multiple Myeloma: Prevention

[+]

These results suggest that combined administration of black soybean with fenofibrate enhances the antihyperlipidemic action of fenofibrate.Jun 01, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Jun ;18(6):615-8. Epub 2015 Feb 4. PMID: 25651043

Article Published Date : Jun 01, 2015

Study Type : Human Study

Additional Links

Substances : Polyphenols, Soy

Diseases : Diabetes Mellitus: Type 2, Hyperlipidemia

Additional Keywords : Drug Synergy, Phytotherapy, Plant Extracts

[+]

This study clarified the association between habitual miso consumption and good glycemic control, including glycemic variability in females.Apr 27, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Invest Dermatol. 2003 May ;120(5):835-41. PMID: 12713590

Article Published Date : May 01, 2003

Study Type : Human Study

Additional Links

Substances : Genistein, NAC (N-acetyl-L-cysteine)

Diseases : Aging

Pharmacological Actions : Antioxidants

[+]

Vaginally administered genistein and hyaluronic acid both improve symptoms of vaginal atrophy in postmenopausal women.May 31, 2011

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Pubmed Data : Arch Gynecol Obstet. 2011 Jun ;283(6):1319-23. Epub 2010 Jun 25. PMID: 20577750

Pubmed Data : Hum Exp Toxicol. 2011 Dec ;30(12):1931-44. Epub 2011 Mar 15. PMID: 21406484

Article Published Date : Nov 30, 2011

Study Type : Human In Vitro

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Substances : Chrysanthemum Indicum, Soy

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Renoprotective

Additional Keywords : Plant Extracts

[+]

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

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Pubmed Data : Indian J Pharmacol. 2016 Nov-Dec;48(6):637-642. PMID: 28066099

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Pubmed Data : Pediatrics. 2012 Sep ;130(3):e699-702. Epub 2012 Aug 20. PMID: 22908106

Article Published Date : Aug 31, 2012

Study Type : Human: Case Report

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Substances : Soy

Diseases : Congenital Hypothyroidism

Problem Substances : Soy

Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid

[+]

Dietary genistein supplementation protects against lipopolysaccharide-induced intestinal injury through altering transcriptomic profile.Jun 30, 2020

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Pubmed Data : J Med Food. 2008 Sep;11(3):539-43. PMID: 18800904

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Pubmed Data : Vascul Pharmacol. 2008 Jul;49(1):1-5. Epub 2008 Mar 27. PMID: 18468493

Article Published Date : Jul 01, 2008

Study Type : Animal Study

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Substances : Genistein

Diseases : Diabetes: Cardiovascular Illness

Pharmacological Actions : Cardioprotective, Enzyme Inhibitors

[+]

Coffee contains the isoflavones genistein, daidzein and formononetin.Mar 10, 2010

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Pubmed Data : J Agric Food Chem. 2010 Mar 10;58(5):3002-7. PMID: 20131840

Article Published Date : Mar 10, 2010

Study Type : Animal Study

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Substances : Coffee, Daidzein, Genistein, Isoflavones

Additional Keywords : Substances that are Linked

[+]

Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis.Jul 27, 2022

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Pubmed Data : Sci Rep. 2022 Jul 28 ;12(1):12950. Epub 2022 Jul 28. PMID: 35902739

Article Published Date : Jul 27, 2022

Study Type : Animal Study

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Substances : Genistein

Diseases : Inflammation

Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Cytoprotective, NF-kappaB Inhibitor, Pancreato Protective Agents

Problem Substances : Dexamethasone

[+]

Dark soy sauce has a protective effect against acrylamide-induced neurotoxicity in rats by antioxidative activity.Jun 01, 2009

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Pubmed Data : Toxicol Mech Methods. 2009 Jun;19(5):369-74. PMID: 19778214

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Pubmed Data : Life Sci. 2003 Jul 25;73(10):1289-98. PMID: 12850244

Article Published Date : Jul 25, 2003

Study Type : Animal Study

Additional Links

Substances : Nattokinase, Soy

Diseases : Arteriosclerosis, Intima Media Thickening

[+]

Dietary supplementation with 180-day fermented dietary miso could act as a chemopreventive agent for colon carcinogenesis.Dec 01, 2005

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Pubmed Data : Oncol Rep. 2005 Dec;14(6):1559-64. PMID: 16273256

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:1560435. Epub 2022 May 17. PMID: 35620577

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 Feb 10 ;18(2). Epub 2017 Feb 10. PMID: 28208647

Article Published Date : Feb 09, 2017

Study Type : Animal Study

Additional Links

Substances : Soy

Diseases : Atherosclerosis

Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Fermented barley and soybean alleviated the severity of colitis in a DSS-induced colitis mouse model.Dec 02, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Dec 3 ;16(1):498. Epub 2016 Dec 3. PMID: 27912750

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Pubmed Data : Int J Reprod Biomed (Yazd). 2016 Feb ;14(2):95-102. PMID: 27200423

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Infertility: Male

Pharmacological Actions : Spermatogenic

Problem Substances : Morphine

[+]

Genistein administration might improve liver damages induced by morphine in mice.Jul 04, 2018

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Pubmed Data : Chin Med J (Engl). 2018 Jul 5 ;131(13):1598-1604. PMID: 29941714

[+]

Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress.Jan 31, 2016

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Pubmed Data : J Physiol Pharmacol. 2016 Feb ;67(1):129-37. PMID: 27010902

Article Published Date : Jan 31, 2016

Study Type : Animal Study

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Substances : Genistein

Diseases : Ischemia

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cytoprotective

[+]

Genistein ameliorated experimentally induced gastric ulcer.Nov 30, 2023

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Pubmed Data : Neurotox Res. 2020 Jul 1. Epub 2020 Jul 1. PMID: 32613603

Article Published Date : Jun 30, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Genistein

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Genistein and moderate intensity exercise were effective in reducing the severity of NASH.May 31, 2020

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Pubmed Data : BMC Complement Med Ther. 2020 Jun 1 ;20(1):162. Epub 2020 Jun 1. PMID: 32482167

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Pubmed Data : BMC Complement Med Ther. 2022 Aug 4 ;22(1):208. Epub 2022 Aug 4. PMID: 35927726

Article Published Date : Aug 03, 2022

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Inflammation, Oxidative Stress, Pancreatitis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, NF-kappaB Inhibitor

[+]

Genistein attenuates acute cerebral ischemic damage. Dec 31, 2019

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Pubmed Data : Eur J Pharmacol. 2010 Dec 15;649(1-3):242-8. Epub 2010 Sep 18. PMID: 20854807

Article Published Date : Dec 15, 2010

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Pulmonary Hypertension

Pharmacological Actions : Nitric Oxide Enhancer

[+]

Genistein attenuates renal ischemia-reperfusion injury.Dec 31, 2022

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Pubmed Data : Hum Exp Toxicol. 2023 ;42:9603271231164913. PMID: 36932924

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Ischemia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

[+]

Genistein diet improves body weight, serum glucose and triglyceride levels.Dec 31, 2018

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Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:2011-2021. Epub 2019 Oct 3. PMID: 31686880

Pubmed Data : Urology. 2004 Aug;64(2):389-93. PMID: 15302513

Article Published Date : Aug 01, 2004

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Kidney Cancer

[+]

Genistein Inhibits Clostridioides difficile Infection.Mar 27, 2023

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Pubmed Data : J Infect Dis. 2023 Mar 28 ;227(6):806-819. PMID: 36628948

Article Published Date : Mar 27, 2023

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Clostridium Infections

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

[+]

Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BTG2 and adipor1.Feb 29, 2020

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Pubmed Data : Food Funct. 2020 Mar 1 ;11(3):2418-2426. Epub 2020 Mar 4. PMID: 32129363

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Pubmed Data : Shock. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31626039

Article Published Date : Oct 14, 2019

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Burns

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Genistein protects against hyperglycemia and fatty liver disease in diet-induced prediabetes.Dec 31, 2021

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Pubmed Data : Neurotoxicology. 2016 Mar ;53:153-164. Epub 2016 Jan 18. PMID: 26797587

Article Published Date : Feb 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Genistein

Diseases : Lead Poisoning, Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation

Problem Substances : Lead

[+]

Genistein reduces hyperglycemia and pancreatic islet cell loss in a rat model of diabetic pancreatic damage.Feb 01, 2007

Genistein supplementation might be a potential therapeutic line for the management and prevention of diabetes-associated OCD.Mar 20, 2018

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2018 Mar 21. Epub 2018 Mar 21. PMID: 29561730

Article Published Date : Mar 20, 2018

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Diabetic Complications, Obsessive-Compulsive Disorder

Pharmacological Actions : Neuroprotective Agents

[+]

Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer.Feb 07, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Clin Biochem Nutr. 2018 Mar ;62(2):148-154. Epub 2017 Dec 12. PMID: 29610554

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Soy

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Alpha-glucosidase inhibitor , Hypoglycemic Agents

[+]

In utero and postnatal isoflavone exposureappears to reduce the risk to develop breast cancer.Dec 20, 2011

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Pubmed Data : Mol Nutr Food Res. 2011 Dec 20. Epub 2011 Dec 20. PMID: 22183799

Article Published Date : Dec 20, 2011

Study Type : Animal Study

Additional Links

Substances : Genistein, Isoflavones

Diseases : Breast Cancer: Chemically-Induced, Prenatal Chemical Exposures

Pharmacological Actions : Chemopreventive

[+]

In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from chemically-induced mammary tumorigenesis.Aug 07, 2008

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Pubmed Data : EMBO J. 2008 Aug 7; PMID: 17166883

Article Published Date : Aug 07, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein, Soy Protein

Diseases : Prenatal Nutrition: Health of the Offspring

Pharmacological Actions : Chemopreventive

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View the Evidence: 627 Abstracts with Soy Research

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High total soy product consumption, especially soymilk and tofu, is associated with lower cancer risk.Mar 27, 2024

"Soy intake is associated with lower lung cancer risk." Dec 01, 2011

Exposure to isoflavone-containing soy products may improve endothelial function. Aug 14, 2010

Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women.Feb 28, 2017

Safety Study: There is little evidence that in those with normal thyroid function soy has any adverse effects. In those with hypothyroidism adequate iodine should be consumed to counterbalance the soy consumption.Mar 01, 2006

A combination of selenium, vitamin E and soy isoflavones reduces PSA levels and ower risk of prostate cancer in men with high-grade intraepithelial neoplasia. Jun 01, 2007

A combination of soy, isoflavones, lycopene, silymarin and antoxidants significantly increases PSA doubling time in men with prostate cancer. Dec 01, 2005

A daily supplement of soy protein prevents the increase in subcutaneous and total abdominal fat in postmenopausal women. Dec 01, 2007

A diet high in plant sterols, soy protein, viscous fibers and almonds compares favorably to statin therapy in reducing C-reactive protein. Jul 01, 2005

A diet high in soy products may be protective against the development of subarachnoid hemorrhage.Apr 01, 2006

A dietary pattern characterized by high intakes of vegetables, fruit, soy products, and fish, is significantly and inversely related to circulating high-sensitivity C-reactive protein. May 01, 2008

A high intake of some fruits, vegetables, and soybeans may be associated with a reduced breast cancer risk.Mar 01, 2007

A high intake of soy and isoflavones may be associated with a reduced prevalence of allergic rhinitis.Jun 01, 2005

A higher intake of soy foods and soy isoflavones is associated with lower sperm concentration.Nov 01, 2008

A low glycemic index diet with soy protein and phytosterols improves risk factors for cardiovascular disease in postmenopausal women.Feb 01, 2006

A moisturizer containing compounds found within soy is safe and effective in preventing photoaging. Sep 01, 2007

A multi-nutrient mixture of soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract improves signs of skin aging in post-menopausal women. Oct 01, 2006

A soy rich diet may prevent the vaginal atrophy in postmenopause. Jan 01, 2008

A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women.Feb 24, 2010

Among women with breast cancer, soy food consumption was significantly associated with decreased risk of death and recurrence.Dec 09, 2009

An increased intake of some fruits, vegetables, and soy foods may be associated with breast cancer risk reduction in Korean women.Jan 01, 2007

Avocado/soybean unsaponifiables appear to have a preventive effect on joint space loss in osteoarthritis of the hip.Feb 01, 2002

Avocado/soybean unsaponifiables are safe and effective in the treatment of symptomatic osteoarthritis of the knee and hip.Dec 01, 1997

Consumption of legumes, soybeans in particular, was inversely associated with the risk type 2 diabetes. Jan 01, 2008

Consumption of soy foods may be associated with a reduction in colorectal cancer risk in women. Jan 01, 2010

Daily supplementation of dried beancurd could increase BMD of lumbar spine.Nov 30, 2019

Dietary intake of isoflavone is inversely associated with the risk of lower urinary tract symptoms. Dec 01, 2007

Dietary soy supplementation constitutes an effective alternative therapy for somatic and urogenital symptoms of the menopause.Nov 01, 2010

Early-life soy exposure is associated with early onset menarche.Mar 01, 2012

Effectiveness of genistein supplementation on metabolic factors and antioxidant Status in postmenopausal women with type 2 diabetes mellitus.Sep 30, 2019

Effects of a combination of botanical actives on skin health and antioxidant status in post-menopausal women.Apr 30, 2022

Effects of genistein aglycone in glucocorticoid induced osteoporosis.Jun 30, 2023

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

Fermented soymilk beneficially modifies the gut microbiota in premenopausal healthy women.Feb 26, 2018

Frequent miso soup and isoflavone consumption is associated with a reduced risk of breast cancer in Japanese women. Jun 18, 2003

Genistein and daidzein consumption are associated with a lower risk of prostate cancer. Aug 01, 2009

Genistein and puerarin could inhibit the pathway of NF-kappaB and TNF-alpha in asthma patients.Jan 31, 2010

Genistein appears to have a positive effect on hot flushes without a negative impact on endometrial thickness in early postmenopausal women.Jul 01, 2004

Genistein can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD.May 31, 2017

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.Oct 01, 2002

Genistein has a positive effect on bone metabolism in osteopenic postmenopausal women, without increasing endometrial thickness. Jun 19, 2007

Genistein has favorable effects on some predictors of cardiovascular risk in osteopenic, postmenopausal women.Jan 18, 2010

Genistein has therapeutic value in reducing PSA levels in men with prostate cancer. Feb 01, 2004

Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients.Jun 17, 2022

Genistein inhibits nonalcoholic fatty liver disease.Nov 01, 2007

Genistein is safe and effective in improving bone density without adverse responses in breast density or endometrium thickness in osteopenic, postmenopausal women. Dec 01, 2008

Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression. Aug 19, 2009

Genistein reduces vasomotor symptoms, e.g. hot flush, within postmenopausal women.Jul 01, 2007

Genistein significantly decreases hot flash symptoms in healthy postmenopausal women.Feb 01, 2011

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects. Dec 31, 2019

Habitual miso consumption is associated with a low prevalence of sarcopenia in patients with type 2 diabetes.Dec 27, 2020

High dietary intake of soy isoflavones was associated with lower risk of recurrence among post-menopausal patients with breast cancer positive for estrogen and progesterone receptor and those who were receiving anastrozole (Arimidex) as endocrine therapy.Feb 01, 2010

Higher concentrations of circulating genistein may reduce the risk of prostate cancer.Jun 02, 2009

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations.Jan 13, 2021

Increased consumption of genistein is associated with better lung function in patients with asthma. Jan 01, 2004

Increasing dietary consumption of tomato based foods may beneficially increase serum adiponectin concentrations among postmenopausal women at increased breast cancer risk.Jan 31, 2014

Increasing soy consumption is associated with a decreased risk of COPD and breathlessness.Jan 01, 2009

Intake of miso soup was associated with lower epigastric symptoms.Dec 31, 2017

Isoflavone intake was associated with a decreased risk of lung cancer. Jan 13, 2010

Isoflavone-rich soy protein suppresses androgen receptor expression in men at high risk of prostate cancer. Jul 01, 2007

Japanese soy sauce fermentation degrades wheat allergen as determined by children with wheat allergy.Jun 01, 2004

Liquorice and soy sauce has been reported a life-saving concoction in a patient with Addison's disease.Jun 30, 2007

Long-term intake of miso soup decreases nighttime blood pressure in subjects with high-normal blood pressure or stage I hypertension.Aug 01, 2019

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.Jul 01, 2009

Miso soup consumption enhances the bioavailability of the reduced form of supplemental coenzyme Q10.Dec 31, 2019

Mortality from Lung Cancer, Breast Cancer and Ischemic Heart Disease is inversely associated with soy consumption. Jul 01, 2006

Mycoprotein and tofu have satiating properties that persist for several hours after a meal.Jan 01, 2006

Oral intake of soy isoflavone aglycone improves the aged skin of adult women.Feb 01, 2007

Regular soy food intake may be associated with a reduced risk of breast cancer, and this effect is more pronounced in premenopausal women.Jan 01, 2008

Resveratrol and genistein may be potential drugs candidates for use in the treatment of COPD.Mar 27, 2016

Safety Study: dietary soy consumption during early pregnancy is not associated with the development of thyroid dysfunction or autoimmunity.Aug 25, 2001

View the Evidence:
627 Abstracts with Soy Research