St. Johns Wort

Name	AC	CK
Wound Healing	6	29
Depression	6	23
Depression	1	20
Ear Infection	2	20
Perimenopausal Syndrome	2	20
Opiate Addiction/Withdrawal	2	12
Actinic Keratosis	1	10
Atopic Dermatitis	1	10
Autism	1	10
Basal Cell Carcinoma	1	10
Bowen's Disease	1	10
Cesarean Section	1	10
Chemotherapy and Radiation Toxicity	1	10
Chemotherapy-Induced Toxicity: Cisplatin	1	10
Colitis	1	10
Diarrhea	1	10
Episiotomy	1	10
Head and Neck Cancer	1	10
Heroin Addication/Withdrawal	1	10
Hot Flash	1	10
Memory Disorders	1	10
Mesothelioma	1	10
Otitis media	1	10
Quality of Life: Poor	1	10
Seasonal Affective Disorder	1	10
Tobacco Addiction/Withdrawal	1	10
Diabetic Complications	4	8
Inflammation	4	6
Multiple Sclerosis	4	6
HIV Infections	5	5
Oxidative Stress	3	5
Burns	2	4
Smoking Cessation: Nicotine Addiction	2	4
Wound Healing: Delayed	2	4
Aluminum Toxicity	2	3
Bedsore	1	3
Brain: Oxidative Stress	2	3
Cancer Metastasis	3	3
Cancers: All	3	3
Crigler-Najjar syndrome	1	3
Hyperbilirubinemia: Hereditary	1	3
Nasopharyngeal Cancer	2	3
Parkinson's Disease	2	3
Trigeminal Neuralgia	1	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging: Brain	1	2
Alcohol Withdrawal	1	2
Alzheimer's Disease	1	2
Anxiety	1	2
Brain Inflammation	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Colorectal Cancer	1	2
Colorectal Cancer: Prevention	1	2
Cystic Fibrosis	1	2
Diabetic Nephropathy	1	2
Diabetic Neuropathy	1	2
Endometriosis	1	2
Epilepsy	1	2
Excitotoxicity	1	2
Gastric Ulcer	1	2
Hypercholesterolemia	1	2
Hyperlipidemia	1	2
Incontinence	1	2
Incontinence: Urinary	1	2
Influenza A	1	2
Ischemia	1	2
Kidney Damage	1	2
Leukemia	2	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	2	2
Lipid Peroxidation	1	2
Memory Loss	1	2
Pain	1	2
Pertussis	1	2
Pleurisy	1	2
Pulmonary Fibrosis	1	2
Sciatic Nerve Crush Injury	1	2
Staphylococcus aureus infection	2	2
Stroke: Attenuation/Recovery	1	2
Whooping Cough	1	2
Breast Cancer	1	1
Cancers: Drug Resistant	1	1
Chemotherapy-Induced Toxicity: Oxaliplatin	1	1
Chronic Pain	1	1
Colon Cancer	1	1
Coronavirus Infection	1	1
Cytomegalovirus Infections	1	1
Diabetes Mellitus: Type 1	1	1
Diabetes Mellitus: Type 1: Prevention	1	1
Glioblastoma	1	1
Leukemia: B-Cell	1	1
Mastalgia	1	1
Obesity	1	1
Postnatal Depression	1	1
Premenstrual syndrome	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Scars	1	1
Uterus: Contraction/Expulsion Disorders	1	1
Cortisol: High	1	0
Pancreatic Cancer	1	0

Name	AC	CK
Antidepressive Agents	5	42
Neuroprotective Agents	9	24
Anti-Inflammatory Agents	12	19
Analgesics	5	18
Antioxidants	11	17
Chemoprotective Agents	2	11
Radioprotective	1	10
Apoptotic	6	7
Antiproliferative	6	6
Immunomodulatory	4	6
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	6
Antiviral Agents	4	5
Hypolipidemic	2	4
Interleukin-6 Downregulation	2	4
Renoprotective	2	4
Anti-Angiogenic	3	3
Anti-metastatic	3	3
Chemopreventive	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	3
Anti-Anxiety Agents	1	2
Anti-Apoptotic	1	2
Anti-Bacterial Agents	2	2
Anti-Tumor	1	2
Anticarcinogenic Agents	1	2
Anticholesteremic Agents	1	2
Autophagy Inhibitors	1	2
Excitatory Amino Acid Agonists	1	2
Gastrointestinal Agents	1	2
Gastroprotective	1	2
Hepatoprotective	1	2
Interleukin-1 alpha downregulation	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Anti-HIV Agents	1	1
Antinoceceptive	1	1
Chemotherapeutic	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
NF-kappaB Inhibitor	1	1
Pancreato Protective Agents	1	1
Quorum Sensing Inhibition	1	1
Uterotonic	1	1

[+]

St John's wort has comparable efficacy and safety when compared to SSRIs in patients with mild-to-moderate depression.Jan 02, 2017

Click here to read the entire abstract

Pubmed Data : J Affect Disord. 2017 Jan 3 ;210:211-221. Epub 2017 Jan 3. PMID: 28064110

Article Published Date : Jan 02, 2017

Study Type : Meta Analysis

Additional Links

Substances : St. Johns Wort

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Antidepressive Agents, Depression, Plant Extracts, St. Johns Wort

[+]

A combination of garlic, mullein, calendula, st. johns wort and olive oil is as effective as an anesthetic drug for the management of acute otitis media-associated pain. Jul 01, 2001

Click here to read the entire abstract

Pubmed Data : Arch Pediatr Adolesc Med. 2001 Jul;155(7):796-9. PMID: 11434846

Article Published Date : Jul 01, 2001

Study Type : Human Study

Additional Links

Substances : Calendula, Garlic, Mullein, Olive, St. Johns Wort

Diseases : Ear Infection, Otitis media

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

[+]

A combination of Hypericum perforatum (St. johns wort) and Vitex agnus-castus improves PMS-like symptoms in late-perimenopausal women. Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2009 Sep;15(9):1045-8. PMID: 19757982

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : St. Johns Wort, Vitex Agnus

Diseases : Perimenopausal Syndrome

[+]

Achillea millefolium and Hypericum perforatum ointments reduce perineal pain level, redness, edema and ecchymosis of episiotomy wound.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : J Matern Fetal Neonatal Med. 2018 Jan ;31(1):63-69. Epub 2017 Feb 23. PMID: 28027682

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : St. Johns Wort, Yarrow

Diseases : Episiotomy, Wound Healing

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Dandelion, St. Johns Wort, Melissa (Lemonbalm), Marigold, and Fennel have therpaeutic effects in treating colitis and diarrhea syndrome. Jan 01, 1981

Click here to read the entire abstract

Pubmed Data : Vutr Boles. 1981;20(6):51-4. PMID: 7336706

Article Published Date : Jan 01, 1981

Study Type : Human Study

Additional Links

Substances : Dandelion , Fennel, Marigold, Melissa (Lemonbalm), St. Johns Wort

Diseases : Colitis, Diarrhea

Additional Keywords : Plant Extracts

[+]

Hypericin, a compound found within St. John's wort, may have therapeutic value in the treatment of mesothelioma. Oct 01, 1990

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 1990 Oct;30(3):295-300. PMID: 9002247

Article Published Date : Oct 01, 1990

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Mesothelioma

Therapeutic Actions : Photodynamic therapy

[+]

Hypericum (st. john's wort) has therapeutic value in the treatment of seasonal affective disorder.Sep 01, 1997

Click here to read the entire abstract

Pubmed Data : Pharmacopsychiatry. 1997 Sep;30 Suppl 2:89-93. PMID: 17151164

Article Published Date : Sep 01, 1997

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Seasonal Affective Disorder

[+]

Hypericum perforatum (syn. St.John's wort) improves hot flashes and quality of life in perimenopausal women. Feb 01, 2005

Click here to read the entire abstract

Pubmed Data : J Adv Nurs. 2005 Feb;49(3):234-44. PMID: 19194342

Article Published Date : Feb 01, 2005

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Hot Flash, Perimenopausal Syndrome, Quality of Life: Poor

[+]

Naturopathic treatment for ear pain is demonstrated superior to antibiotic treatment.May 01, 2003

Click here to read the entire abstract

Pubmed Data : Pediatrics. 2003 May;111(5 Pt 1):e574-9. PMID: 12728112

Article Published Date : May 01, 2003

Study Type : Human Study

Additional Links

Substances : Calendula, Garlic, Lavender, Mullein, Olive, St. Johns Wort, Vitamin E

Diseases : Ear Infection

Additional Keywords : Natural Substances Versus Drugs

[+]

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Med Oncol. 2017 Feb ;34(2):30. Epub 2017 Jan 18. PMID: 28101834

Article Published Date : Jan 31, 2017

Study Type : Human Study

Additional Links

Substances : Neem, St. Johns Wort

Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Cisplatin, Head and Neck Cancer

Pharmacological Actions : Chemoprotective Agents, Radioprotective

[+]

Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract.Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : Panminerva Med. 2018 Dec ;60(4):156-160. Epub 2018 Jul 10. PMID: 29991209

Article Published Date : Nov 30, 2018

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

St John's Wort is modestly effective in the short-term treatment of irritability in some patients with autistic disorder.Jan 01, 1997

Click here to read the entire abstract

Pubmed Data : Oncol Res. 1997;9(1):31-9. PMID: 19274686

Article Published Date : Jan 01, 1997

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Autism

[+]

St. John's Wort in combination with photodynamic therapy demonstrates therapeutic effects in Actinic Keratosis, Basal Cell Carcinoma and Bowen's disease. May 01, 2008

Click here to read the entire abstract

Pubmed Data : Photochem Photobiol. 2008 May-Jun;84(3):779-85. Epub 2008 Jan 7 PMID: 18179625

Article Published Date : May 01, 2008

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Actinic Keratosis, Basal Cell Carcinoma, Bowen's Disease

[+]

St. John's wort may contribute to easing physical dependence and withdrawal syndrome associated with heroin addiction. Mar 01, 2007

Click here to read the entire abstract

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2007 Mar;131(1):61-7. Epub 2006 Nov 17. PMID: 19067385

Article Published Date : Mar 01, 2007

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Heroin Addication/Withdrawal, Opiate Addiction/Withdrawal

[+]

St. Johns Wort may reduce the withdrawal signs associated with nicotine addiction. Oct 01, 2007

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2007 Oct;14(10):645-51. Epub 2007 Aug 6. PMID: 17689233

Article Published Date : Oct 01, 2007

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Tobacco Addiction/Withdrawal

[+]

Subchronic treatment with St John's wort produces a positive shift in emotional processing in healthy volunteers.Nov 27, 2018

Click here to read the entire abstract

Pubmed Data : J Psychopharmacol. 2018 Nov 28:269881118812101. Epub 2018 Nov 28. PMID: 30484733

Article Published Date : Nov 27, 2018

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Topical application of H. perforatum is safe and can facilitate cesarean wound healing and minimize formation of scar, pain and itching.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2010 Jan;16(1):113-7. PMID: 20064022

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Cesarean Section, Wound Healing

[+]

Topical St. John's wort cream may improve Atopical Dermatitis. Jan 01, 2003

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2003;10 Suppl 4:31-7. PMID: 12807340

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Atopic Dermatitis

[+]

Treatment of osteomyelitis in the feet of diabetic patients by photodynamic antimicrobial chemotherapy.Jan 31, 2009

Click here to read the entire abstract

Pubmed Data : Photomed Laser Surg. 2009 Feb ;27(1):145-50. PMID: 19196112

Article Published Date : Jan 31, 2009

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Diabetic Complications, Osteomyelitis

Therapeutic Actions : Photodynamic therapy

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Phytotherapy

[+]

Treatment with small dosages of H. perforatum has a positive effect on the capacity of short-term verbal memory.Oct 30, 2018

Click here to read the entire abstract

Pubmed Data : Psychopharmacology (Berl). 2018 Oct 31. Epub 2018 Oct 31. PMID: 30382352

Article Published Date : Oct 30, 2018

Study Type : Human Study

Additional Links

Substances : St. Johns Wort

Diseases : Memory Disorders

Pharmacological Actions : Neuroprotective Agents

[+]

Hypericum perforatum may be a promising therapeutic option for trigeminal neuralgia.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Complement Ther Med. 2017 Feb ;30:36-39. Epub 2016 Nov 17. PMID: 28137525

Article Published Date : Jan 31, 2017

Study Type : Human: Case Report

Additional Links

Substances : St. Johns Wort

Diseases : Trigeminal Neuralgia

Pharmacological Actions : Analgesics

[+]

St. John's wort oily extract may be suggested as a cost-effective option for the prevention or treatment of pressure sores in ICU patients.Jan 19, 2017

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2017 Jan 20 ;196:236-241. Epub 2016 Dec 21. PMID: 28011162

Article Published Date : Jan 19, 2017

Study Type : Human: Case Report

Additional Links

Substances : St. Johns Wort

Diseases : Bedsore, Wound Healing

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

St. Johns Wort extract is a potential alternative to phenobarbital in patients with Crigler-Najjar syndrome type II.Dec 20, 2015

Click here to read the entire abstract

Pubmed Data : Br J Clin Pharmacol. 2015 Dec 21. Epub 2015 Dec 21. PMID: 26692114

Article Published Date : Dec 20, 2015

Study Type : Human: Case Report

Additional Links

Substances : St. Johns Wort

Diseases : Crigler-Najjar syndrome, Hyperbilirubinemia: Hereditary

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

[+]

A marine-herbal combination containing prawns, celery seed and st. john's wort has therapeutic value in an animal model of multiple sclerosis.Aug 01, 2008

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2008 Aug;22(8):1083-6. PMID: 18570265

Article Published Date : Aug 01, 2008

Study Type : Animal Study

Additional Links

Substances : Celery seed, Penaeus Latisculatus (prawn), St. Johns Wort

Diseases : Multiple Sclerosis

[+]

An extract of St. Johns Wort has significant therapeutic efficacy for mice infected with influenza A virus.Jan 31, 2012

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2012 Feb ;90(2):123-30. Epub 2012 Jan 20. PMID: 22260349

Article Published Date : Jan 31, 2012

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Influenza A

Pharmacological Actions : Antiviral Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Application of Hypericum perforatum may be recommended as it was effective on wound healing in diabetic rats.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Wounds. 2017 Feb ;29(2):E10-E17. PMID: 28272017

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Diabetic Complications, Wound Healing

[+]

Aqueous St. Johns Wort reduced the serum lipid profiles of rats in terms of LDL-CH.Apr 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Res Cardiovasc Med. 2016 May ;5(2):e31326. Epub 2016 Mar 5. PMID: 26949689

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Hyperlipidemia, Lipid Peroxidation

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

Additional Keywords : Plant Extracts

[+]

Both curcumin and Hypericum perforatum oil are effective in burn wound healing.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6462956. Epub 2020 Feb 13. PMID: 32148546

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, St. Johns Wort

Diseases : Burns, Wound Healing

[+]

Effectiveness of Hypericum perforatum extract in the treatment of corrosive esophageal burns.May 16, 2021

Click here to read the entire abstract

Pubmed Data : J Invest Surg. 2021 May 17:1-6. Epub 2021 May 17. PMID: 33998353

Article Published Date : May 16, 2021

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Burns

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Extracts of Hypericum perforatum (St. John's wort) heal gastric lesions induced in rats. Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Saudi Med J. 2009 Jun;30(6):750-4. PMID: 19526154

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Gastric Ulcer

Additional Keywords : Natural Substances Versus Drugs, Ranitidine

[+]

Hyperforin could promote functional recovery when delivered in the later phases of stroke recovery.Aug 31, 2016

Click here to read the entire abstract

Pubmed Data : Brain Res. 2016 Sep 1 ;1646:504-13. Epub 2016 Jun 17. PMID: 27328426

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Substances : Hyperforin, St. Johns Wort

Diseases : Stroke: Attenuation/Recovery

Pharmacological Actions : Interleukin-17 downregulation, Neuroprotective Agents

[+]

Hyperforin, a compound found with St. Johns wort, may have a therapeutic role in reducing pleurisy in a rat model. Aug 01, 2009

Click here to read the entire abstract

Pubmed Data : Cell Mol Life Sci. 2009 Aug;66(16):2759-71. Epub 2009 Jul 5. PMID: 19579006

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Pleurisy

[+]

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Click here to read the entire abstract

Pubmed Data : J Pharmacol Exp Ther. 2007 May;321(2):492-500. Epub 2007 Feb 8. PMID: 17289834

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Cystic Fibrosis, Pulmonary Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Hypericin, a compound found within St. John's wort, in combination with photodynamic therapy induces cell death in nasopharyngeal cancer. Nov 01, 2003

Click here to read the entire abstract

Pubmed Data : Int J Oncol. 2003 Nov;23(5):1401-5. PMID: 14532982

Article Published Date : Nov 01, 2003

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Nasopharyngeal Cancer

Therapeutic Actions : Light Therapy

Pharmacological Actions : Anti-Tumor, Antioxidants, Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Hypericum perforatum can ameliorate estrogen deficiency-induced hypercholesterolemia.Feb 28, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2021 Mar ;135:111131. Epub 2020 Dec 28. PMID: 33383372

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Hypercholesterolemia

Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic

[+]

Hypericum perforatum extract has neuroprotection actions against aluminum chloride-induced Alzheimer's disease like pathology.May 12, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 May 13 ;91:931-937. Epub 2017 May 13. PMID: 28514831

Article Published Date : May 12, 2017

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Aluminum Toxicity , Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum Chloride

[+]

Hypericum Perforatum is protective against acute renal Ischemia/reperfusion injury. Oct 31, 2017

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2017 Nov ;39(1):385-391. PMID: 28209087

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Ischemia, Kidney Damage

Pharmacological Actions : Renoprotective

[+]

Hypericum perforatum L is a promising chemopreventive agent.Jun 30, 2021

Click here to read the entire abstract

Pubmed Data : Arch Oral Biol. 2021 Jul ;127:105139. Epub 2021 Apr 30. PMID: 33964648

Article Published Date : Jun 30, 2021

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Chemopreventive

Additional Keywords : Plant Extracts

[+]

Hypericum perforatum may improve anxiety-like behaviour and offer brain protection by modulation of oxidative stress and inflammation.Sep 30, 2018

Click here to read the entire abstract

Pubmed Data : J Physiol Pharmacol. 2018 Oct ;69(5). Epub 2019 Jan 21. PMID: 30683830

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Anxiety, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

[+]

Hypericum perforatum reduces paracetamol-induced hepatotoxicity and lethality.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2015 Jul ;29(7):1097-101. Epub 2015 Apr 8. PMID: 25851311

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hypericum perforatum supplementation could be useful in sciatic nerve injury.May 15, 2017

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2017 May 16. Epub 2017 May 16. PMID: 28508406

Article Published Date : May 15, 2017

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Sciatic Nerve Crush Injury

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants

[+]

Hyperoside alleviates epilepsy-induced neuronal damage.Jul 14, 2020

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2020 Jul 15 ;257:112884. Epub 2020 Apr 18. PMID: 32311482

Article Published Date : Jul 14, 2020

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Epilepsy

Pharmacological Actions : Antioxidants, Autophagy Inhibitors, Neuroprotective Agents

[+]

Natural plant extracts from oak bark, St. john's work leaves and pine buds may have therapeutic activity in supporting natural immunity from Staphylococcus aureus and Bordetella pertussis.Apr 01, 1986

Click here to read the entire abstract

Pubmed Data : Zh Mikrobiol Epidemiol Immunobiol. 1986 Apr(4):71-5. PMID: 3012909

Article Published Date : Apr 01, 1986

Study Type : Animal Study

Additional Links

Substances : Oak, Pine Buds, St. Johns Wort

Diseases : Pertussis, Whooping Cough

Pharmacological Actions : Immunomodulatory

Additional Keywords : Plant Extracts

[+]

Oral St. John's wort has more positive effects on problematic wounds compared with topical St. John's wortJan 19, 2017

Click here to read the entire abstract

Pubmed Data : J Invest Surg. 2017 Jan 20:1-9. Epub 2017 Jan 20. PMID: 28107097

Article Published Date : Jan 19, 2017

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Diabetic Complications, Wound Healing

Additional Keywords : Plant Extracts

[+]

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity. May 01, 2008

Click here to read the entire abstract

Pubmed Data : Neurotox Res. 2008 May-Jun;13(3-4):265-79. PMID: 18522906

Article Published Date : May 01, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin, Kaempferol, Quercetin, St. Johns Wort

Diseases : Excitotoxicity

Pharmacological Actions : Excitatory Amino Acid Agonists, Neuroprotective Agents

[+]

Sea buckthorn and St. John's wort oil may be a promising alternative for the treatment of endometriosis.Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Taiwan J Obstet Gynecol. 2016 Dec ;55(6):786-790. PMID: 28040120

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Sea buckthorn, St. Johns Wort

Diseases : Endometriosis

Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

St John's-wort has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:245328. Epub 2015 Aug 31. PMID: 26417372

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Diabetic Complications, Wound Healing: Delayed

[+]

St. John's Wort and feverfew extracts may become new therapeutic perspectives for painful diabetic peripheral neuropathy. Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Fitoterapia. 2014 Jan ;92:23-33. Epub 2013 Oct 12. PMID: 24125916

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Feverfew, St. Johns Wort

Diseases : Diabetic Neuropathy

Pharmacological Actions : Analgesics

Additional Keywords : Phytotherapy, Plant Extracts

[+]

St. John's wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells.Dec 02, 2015

Click here to read the entire abstract

Pubmed Data : J Immunotoxicol. 2015 Dec 3:1-11. Epub 2015 Dec 3. PMID: 26634391

Article Published Date : Dec 02, 2015

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory

[+]

St. John's wort extract had chemopreventive properties against colorectal cancer through attenuation of pro-inflammatory processes.Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila). 2015 Sep ;8(9):786-95. Epub 2015 Jun 11. PMID: 26069204

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Colorectal Cancer, Colorectal Cancer: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Dose Response, Plant Extracts

[+]

St. John's wort extract is twice as effective as ibuprofen as an analgesic in an animal model of pain. Jul 01, 2004

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2004 Jul;17(2):13-9. PMID: 16414593

Article Published Date : Jul 01, 2004

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Pain

Pharmacological Actions : Analgesics

Additional Keywords : Ibuprofen Alternatives, Superiority of Natural Substances versus Drugs

[+]

St. John's wort is as effective as clonoidine in reducing the symptoms of optiate withdrawal in rats.Jun 01, 2004

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2004 Jun 1;64(11):3757-60. PMID: 19370548

Article Published Date : Jun 01, 2004

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Opiate Addiction/Withdrawal

Additional Keywords : Natural Substances Versus Drugs

[+]

St. John's wort may diminish deleterious effects of aging on spatial memory. Sep 20, 2005

Click here to read the entire abstract

Pubmed Data : AAPS PharmSciTech. 2005 Sep 20;6(1):E74-82. PMID: 20361314

Article Published Date : Sep 20, 2005

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Aging: Brain , Memory Loss

Pharmacological Actions : Neuroprotective Agents

[+]

St. John's wort may lessen urinary incontinence in depressed patients. Jul 01, 2004

Click here to read the entire abstract

Pubmed Data : Urology. 2004 Jul;64(1):168-72. PMID: 15245964

Article Published Date : Jul 01, 2004

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Incontinence, Incontinence: Urinary

[+]

St. John's wort reduces symptoms of alcohol withdrawal in rats. Oct 01, 2006

Click here to read the entire abstract

Pubmed Data : Fundam Clin Pharmacol. 2006 Oct;20(5):481-8. PMID: 16968419

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Alcohol Withdrawal

[+]

St. Johns Wort attenuates nicotine withdrawal signs in mice.Sep 01, 2003

Click here to read the entire abstract

Pubmed Data : Psychopharmacology (Berl). 2003 Sep;169(2):186-9. Epub 2003 Apr 29. PMID: 12719964

Article Published Date : Sep 01, 2003

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Smoking Cessation: Nicotine Addiction

Additional Keywords : Plant Extracts

[+]

St. Johns Wort may be therapeutic in the treatment of nicotine addiction. Jul 07, 2009

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2009 Jul 7. PMID: 19585471

Article Published Date : Jul 07, 2009

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Smoking Cessation: Nicotine Addiction

[+]

St. Johns Wort may have a renoprotective effect against diabetic nephropathy.Jan 11, 2017

Click here to read the entire abstract

Pubmed Data : Clin Exp Pharmacol Physiol. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28079268

Article Published Date : Jan 11, 2017

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective

[+]

The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats.Aug 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur Oral Res. 2018 Sep ;52(3):143-149. Epub 2018 Sep 1. PMID: 30775718

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Diabetic Complications, Wound Healing: Delayed

[+]

The healing effects of St. John's Wort on experimental alkaline corrosive eosephageal and stomach burns.Apr 30, 2020

Click here to read the entire abstract

Pubmed Data : Ulus Travma Acil Cerrahi Derg. 2020 May ;26(3):373-383. PMID: 32436985

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Burns

Pharmacological Actions : Gastroprotective

[+]

The protective effect of hypericin on postpartum depression.Jan 27, 2022

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2022 Jan 28 ;105:108560. Epub 2022 Jan 28. PMID: 35101848

Article Published Date : Jan 27, 2022

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Depression: Postpartum

Therapeutic Actions : Photodynamic therapy

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents

[+]

These findings reveal the beneficial effect of H. perforatum via attenuation of DNA fragmentation, astrogliosis, inflammation, and oxidative stress.Jun 28, 2015

Click here to read the entire abstract

Pubmed Data : Cell Mol Neurobiol. 2015 Jun 29. Epub 2015 Jun 29. PMID: 26119304

Article Published Date : Jun 28, 2015

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Brain: Oxidative Stress, Brain Inflammation , Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

A marine-herbal combination containing prawns, celery seed and st. john's wort has therapeutic value in multiple sclerosis. Jun 01, 2010

Click here to read the entire abstract

Pubmed Data : Chin J Integr Med. 2010 Jun;16(3):270-1. Epub 2010 Aug 8. PMID: 20694784

Article Published Date : Jun 01, 2010

Study Type : Review

Additional Links

Substances : Celery seed, Penaeus Latisculatus (prawn), St. Johns Wort

Diseases : Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts

[+]

A review of effective medicinal plants in the treatment of the cyclic mastalgia.Aug 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacopuncture. 2019 Sep ;22(3):131-139. Epub 2019 Sep 30. PMID: 31673442

Article Published Date : Aug 31, 2019

Study Type : Review

Additional Links

Substances : Chaste Tree (Chasteberry), Curcumin, Ginkgo biloba, Nigella sativa (aka Black Seed), St. Johns Wort, Sweet Orange, Wheat Germ

Diseases : Mastalgia

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants

[+]

A review of herbal therapy in multiple sclerosis.Oct 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Adv Pharm Bull. 2018 Nov ;8(4):575-590. Epub 2018 Nov 29. PMID: 30607330

Article Published Date : Oct 31, 2018

Study Type : Review

Additional Links

Substances : Cannabis, Cranberry, Frankincense, Ginger, Ginkgo biloba, Ginseng, Grape, Kava Kava, Nigella sativa (aka Black Seed), Saffron, St. Johns Wort, Turmeric, Valerian

Diseases : Multiple Sclerosis

[+]

A review of natural antioxidants in the management of Parkinson's disease.Mar 26, 2021

Click here to read the entire abstract

Pubmed Data : J Integr Med. 2021 Mar 27. Epub 2021 Mar 27. PMID: 33863692

Article Published Date : Mar 26, 2021

Study Type : Review

Additional Links

Substances : Ashwagandha, Curcumin, Ginkgo biloba, Hydroxytyrosol, St. Johns Wort

Diseases : Brain: Oxidative Stress, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

A variety of herbs exhibit uterotonic properties.Mar 17, 2010

Click here to read the entire abstract

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):362-365. Epub 2009 Dec 24. PMID: 7314446

Article Published Date : Mar 17, 2010

Study Type : In Vitro Study

Additional Links

Substances : Calendula, Celosia cristata (cockscomb), Chamomile, Comfrey, Plantain, Shepherds purse , St. Johns Wort

Diseases : Uterus: Contraction/Expulsion Disorders

Pharmacological Actions : Uterotonic

Additional Keywords : Plant Extracts

[+]

Adipogenesis inhibitory activity of hypersampsone P from Hypericum subsessileMay 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nat Prod Bioprospect. 2020 Jun ;10(3):163-170. Epub 2020 May 23. PMID: 32447748

Article Published Date : May 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents

[+]

Anti-quorum sensing and anti-biofilm activities of Hypericum perforatum extracts against Pseudomonas aeruginosa.May 09, 2019

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2019 May 10 ;235:293-300. Epub 2019 Feb 11. PMID: 30763694

Article Published Date : May 09, 2019

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Quorum Sensing Inhibition

[+]

Anti-tumor activity of Hypericum perforatum L. and hyperforin through modulation of inflammatory signalling, ROS generation and proton dynamics. Dec 27, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2020 Dec 28 ;10(1). Epub 2020 Dec 28. PMID: 33379141

Article Published Date : Dec 27, 2020

Study Type : Review

Additional Links

Substances : Hyperforin, St. Johns Wort

Diseases : Cancers: All, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemotherapeutic

[+]

Antimicrobial and antibiofilm activity of polyurethane/Hypericum perforatum extract composite.Jan 31, 2019

Click here to read the entire abstract

Pubmed Data : Bioorg Chem. 2019 Feb ;82:224-228. Epub 2018 Aug 11. PMID: 30342304

Article Published Date : Jan 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

Antiproliferative activity of Hypericum perforatum, Achillea millefolium, and Aloe vera in interaction with the prostatic activity of CD82. Sep 30, 2019

Click here to read the entire abstract

Pubmed Data : Rep Biochem Mol Biol. 2019 Oct ;8(3):260-268. PMID: 32274398

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Aloe Vera, St. Johns Wort, Yarrow

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Selective Antiproliferation

[+]

Antiproliferative effects of St. John's Wort, its derivatives, and other Hypericum species in hematologic malignancies.Dec 24, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 Dec 25 ;22(1). Epub 2020 Dec 25. PMID: 33375664

Article Published Date : Dec 24, 2020

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Cancers: All

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

Chemical composition and immunomodulatory activity of Hypericum perforatum essential oils.Jun 16, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomolecules. 2020 Jun 17 ;10(6). Epub 2020 Jun 17. PMID: 32560389

Article Published Date : Jun 16, 2020

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Pharmacological Actions : Immunomodulatory

Additional Keywords : Essential Oils

[+]

Cytotoxic activities of Hypericum perforatum L. extracts against 2D and 3D cancer cell models.May 31, 2021

Click here to read the entire abstract

Pubmed Data : Cytotechnology. 2021 Jun ;73(3):373-389. Epub 2021 Apr 1. PMID: 34149173

Article Published Date : May 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Cancers: All, Cervical Cancer, Lung Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor

[+]

Distinct Hypericum perforatum L. total extracts exert different antitumour activity on erythroleukemic K562 cells.May 21, 2018

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2018 May 22. Epub 2018 May 22. PMID: 29785769

Article Published Date : May 21, 2018

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

H. perforatum could be used as a novel therapeutic strategy for counteracting chemotherapy-induced neuropathy.Apr 30, 2017

Click here to read the entire abstract

Pubmed Data : Z Naturforsch C. 2017 May 1 ;72(5-6):219-226. PMID: 28160544

Article Published Date : Apr 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Chemotherapy-Induced Toxicity: Oxaliplatin

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

H. perforatum root cultures could be a novel lead system for the treatment of hypertrophic scars.Dec 03, 2018

Click here to read the entire abstract

Pubmed Data : Planta Med. 2018 Dec 4. Epub 2018 Dec 4. PMID: 30513539

Article Published Date : Dec 03, 2018

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Scars

Pharmacological Actions : Antiproliferative

[+]

Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John's wort's flowers.Feb 16, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2021 Feb 17 ;11(1):3989. Epub 2021 Feb 17. PMID: 33597594

Article Published Date : Feb 16, 2021

Study Type : In Vitro Study, Plant Study

Additional Links

Substances : Flavonoids, Polyphenols, St. Johns Wort

Pharmacological Actions : Antioxidants

[+]

Hyperforin (a fat-soluble compound from St. John's wort) may improve B-cell Chronic Lymphocytic Leukemia. Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : Leukemia. 2006 Sep;20(9):1519-25. Epub 2006 Jun 22. PMID: 16791262

Article Published Date : Sep 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Leukemia: B-Cell, Leukemia: Chronic Lymphocytic Leukemia (CLL)

Additional Keywords : Hyperforin

[+]

Hyperforin acts as an angiogenesis inhibitor.May 15, 1996

Click here to read the entire abstract

Pubmed Data : Spine (Phila Pa 1976). 1996 May 15;21(10):1147-52. PMID: 16320199

Article Published Date : May 15, 1996

Study Type : Commentary

Additional Links

Substances : St. Johns Wort

Diseases : Cancer Metastasis

Pharmacological Actions : Anti-Angiogenic

[+]

Hyperforin and miquelianin from St. John's wort attenuate gene expression in neuronal cells after dexamethasone-induced stress.Jun 30, 2018

Click here to read the entire abstract

Pubmed Data : Planta Med. 2018 Jul ;84(9-10):696-703. Epub 2018 Mar 2. PMID: 29499586

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hyperforin, St. Johns Wort

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Problem Substances : Dexamethasone

[+]

Hyperforin, a bio-active compound of St. John's Wort, is a new inhibitor of angiogenesis targeting several key steps of the process.Dec 10, 2005

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2005 Dec 10;117(5):775-80. PMID: 15981212

Article Published Date : Dec 10, 2005

Study Type : Review

Additional Links

Substances : St. Johns Wort

Diseases : Cancer Metastasis

Pharmacological Actions : Anti-Angiogenic

[+]

Hyperforin, a compound found with St. Johns wort, have anticancer activity against leukemic cells from patients with B-cell CLL. Mar 01, 2006

Click here to read the entire abstract

Pubmed Data : Leukemia. 2006 Mar;20(3):491-7. PMID: 16424868

Article Published Date : Mar 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Leukemia: Chronic Lymphocytic Leukemia (CLL)

Pharmacological Actions : Apoptotic

[+]

Hypericin exhibited a dose-dependent cytotoxic effect in the MCF-7 cell line. Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2015 ;16:3. Epub 2016 Feb 9. PMID: 26865836

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Dose Response, Natural Substances Versus Drugs

[+]

Hypericin, a compound found within St. John's wort, may have therapeutic value in the treatment of nasopharyngeal cancer with photodynamic therapy. Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : Curr Clin Pharmacol. 2006 Sep;1(3):217-22. PMID: 18666746

Article Published Date : Sep 01, 2006

Study Type : Commentary

Additional Links

Substances : St. Johns Wort

Diseases : Nasopharyngeal Cancer

Therapeutic Actions : Photodynamic therapy

[+]

Hypericum perforatum regulates glutathione redox stress and normalizes Ggt1/Anpep signaling to alleviate OVX-induced kidney dysfunction.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:628651. Epub 2021 Apr 26. PMID: 33981220

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Kidney Damage, Menopausal Syndrome

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease.Feb 13, 2022

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2022 Feb 14 ;290:115107. Epub 2022 Feb 14. PMID: 35176467

Article Published Date : Feb 13, 2022

Study Type : In Vitro Study

Additional Links

Substances : Chinese Skullcap , Fenugreek, Ginkgo biloba, Lavender, Rosemary, St. Johns Wort, Turmeric

Diseases : Alzheimer's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Natural products for COVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies.Sep 26, 2020

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2020 Sep 27. Epub 2020 Sep 27. PMID: 32985017

Article Published Date : Sep 26, 2020

Study Type : Review

Additional Links

Substances : Echinacea, Garlic, Ginger, Licorice, Nigella sativa (aka Black Seed), St. Johns Wort

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory

[+]

Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells.Nov 23, 2018

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2018 Nov 24 ;299:15-26. Epub 2018 Nov 24. PMID: 30481499

Article Published Date : Nov 23, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hyperforin, St. Johns Wort

Diseases : Aluminum Toxicity

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

[+]

On the mechanism of action of anti-inflammatory activity of hypericin.Nov 21, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Nov 22 ;23(12). Epub 2018 Nov 22. PMID: 30467287

Article Published Date : Nov 21, 2018

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Preclinical studies indicate a potential use of St. John's wort in medical pain management.Feb 11, 2017

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28216196

Article Published Date : Feb 11, 2017

Study Type : Review

Additional Links

Substances : St. Johns Wort

Diseases : Chronic Pain

Pharmacological Actions : Antinoceceptive

[+]

Review: antiangogenic effect of selected phytochemicals.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2010 Jan;65(1):57-63. PMID: 20187580

Article Published Date : Jan 01, 2010

Study Type : Review

Additional Links

Substances : Coptis chinensis, Curcumin, Garlic, Panax Ginseng, Resveratrol, Rheum palmatum, St. Johns Wort, Stilbenes

Diseases : Cancer Metastasis

Pharmacological Actions : Anti-Angiogenic, Anti-metastatic

[+]

Role of Hypericum perforatum oil and pomegranate seed oil in wound healing: an in vitro study.Aug 31, 2021

Click here to read the entire abstract

Pubmed Data : Z Naturforsch C J Biosci. 2021 Sep 1. Epub 2021 Sep 1. PMID: 34469641

Article Published Date : Aug 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Pomegranate, St. Johns Wort

Diseases : Wound Healing

Additional Keywords : Plant Oils

[+]

St. John's wort (H. perforatum) inhibits HIV-1 viral infection. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Virol J. 2009;6:101. Epub 2009 Jul 13. PMID: 19594941

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : HIV Infections

Pharmacological Actions : Antiviral Agents

Additional Keywords : Plant Extracts

[+]

St. John's wort and its component hyperforin have promising therapeutic potential for limitation of immune-mediated β-cell dysfunction.Oct 21, 2016

Click here to read the entire abstract

Pubmed Data : Int J Biochem Cell Biol. 2016 Oct 22. Epub 2016 Oct 22. PMID: 27989965

Article Published Date : Oct 21, 2016

Study Type : In Vitro Study

Additional Links

Substances : Hyperforin, St. Johns Wort

Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 1: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Pancreato Protective Agents

Additional Keywords : Gene Expression Regulation

[+]

St. John's Wort contains a novel protein p27SJ which suppresses the HIV-1 virus.Sep 15, 2008

Click here to read the entire abstract

Pubmed Data : Clin Infect Dis. 2008 Sep 15;47(6):804-11. PMID: 18378326

Article Published Date : Sep 15, 2008

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : HIV Infections

[+]

St. John's wort extract induces growth inhibition and programmed cell death in human malignant cells in vitro.Aug 01, 2008

Click here to read the entire abstract

Pubmed Data : J Neurochem. 2008 Aug;106(4):1594-603. Epub 2008 May 31. PMID: 12061257

Article Published Date : Aug 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Cancers: All, Glioblastoma, Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

[+]

St. John's Wort has antiviral activity against CytomegalovirusFeb 01, 1991

Click here to read the entire abstract

Pubmed Data : Antiviral Res. 1991 Feb;15(2):101-12. PMID: 1650164

Article Published Date : Feb 01, 1991

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : Cytomegalovirus Infections

Pharmacological Actions : Antiviral Agents

[+]

St. John's Wort is as effective as Selective Serotoin Reuptake Inhibitors in the treatment of Depressive Disorder, with a greater safety rating. Feb 01, 2009

Click here to read the entire abstract

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):118-27. Epub 2008 Nov 12. PMID: 19028540

Article Published Date : Feb 01, 2009

Study Type : Review

Additional Links

Substances : St. Johns Wort

Diseases : Depression

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

St. John's wort may be a safe treatment option for women suffering from postpartum depression. Jan 01, 2002

Click here to read the entire abstract

Pubmed Data : Pharmacopsychiatry. 2002 Jan;35(1):29-30. PMID: 11819157

Article Published Date : Jan 01, 2002

Study Type : Commentary

Additional Links

Substances : St. Johns Wort

Diseases : Postnatal Depression

[+]

St. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment.Nov 20, 2018

Click here to read the entire abstract

Pubmed Data : J Cell Physiol. 2018 Nov 21. Epub 2018 Nov 21. PMID: 30461013

Article Published Date : Nov 20, 2018

Study Type : Review

Additional Links

Substances : St. Johns Wort

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substances Versus Drugs

[+]

St. John's Wort suppresses HIV-1 virus. Feb 01, 2006

Click here to read the entire abstract

Pubmed Data : Gene Ther. 2006 Feb;13(4):288-95. PMID: 16251997

Article Published Date : Feb 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : HIV Infections

[+]

St. Jonh's wort inhibits ultraviolet light-induced activation of HIV gene expression in HeLa cells. Dec 01, 2002

Click here to read the entire abstract

Pubmed Data : IUBMB Life. 2002 Dec;54(6):357-64. PMID: 12665247

Article Published Date : Dec 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : St. Johns Wort

Diseases : HIV Infections

Pharmacological Actions : Anti-HIV Agents, NF-kappaB Inhibitor

[+]

The anti-HIV-1 activity of hypercin (St. John's wort) is dependent on activation through visible light. Feb 01, 1993

Click here to read the entire abstract

Pubmed Data : Antiviral Res. 1993 Feb;20(2):173-8. PMID: 8460933

Article Published Date : Feb 01, 1993

Study Type : Commentary

Additional Links

Substances : St. Johns Wort

Diseases : HIV Infections

Therapeutic Actions : Light Therapy

Pharmacological Actions : Antiviral Agents

[+]

The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells.Oct 31, 2018

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Pubmed Data : Anticancer Drugs. 2018 Nov ;29(10):983-994. PMID: 30063472

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

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Substances : St. Johns Wort

Diseases : Cancers: Drug Resistant, Colon Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

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This preliminary evaluation demonstrated a synergistic property of O. vulgare and H. perforatum extracts in treating S. aureus infection.Feb 28, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Future Sci OA. 2019 Mar ;5(3):FSO371. Epub 2019 Jan 31. PMID: 30906567

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol, Oregano, St. Johns Wort

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance Synergy

[+]

This research demonstrated efficacy and safety of Iranian herbal medicines in alleviating PMS.Feb 28, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2018 Mar-Apr;8(2):96-113. PMID: 29632841

Article Published Date : Feb 28, 2018

Study Type : Review

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Substances : Chamomile, Chaste Tree (Chasteberry), Curcumin, Fennel, Flaxseed, Ginger, Lemon Balm, Orange, Saffron, St. Johns Wort, Valerian, Wheat Germ, Zataria multiflora

Diseases : Premenstrual syndrome

Additional Keywords : Traditional Iranian Medicine

[+]

St. John's wort in combination with photodynamic therapy inhibit the growth of human pancreatic cancer cells. Sep 01, 2000

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Pubmed Data : J Surg Res. 2000 Sep;93(1):137-43. PMID: 10945955

Article Published Date : Sep 01, 2000

Additional Links

Substances : St. Johns Wort

Diseases : Pancreatic Cancer

[+]

St. John's Wort's cortisol reducing effect in brain may contribute to antidepressive effectJan 01, 2004

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Pubmed Data : Eur Neuropsychopharmacol. 2004 Jan;14(1):7-10. PMID:14659982

Article Published Date : Jan 01, 2004

Additional Links

Substances : St. Johns Wort

Diseases : Cortisol: High, Depression

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View the Evidence: 110 Abstracts with St. Johns Wort Research

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St John's wort has comparable efficacy and safety when compared to SSRIs in patients with mild-to-moderate depression.Jan 02, 2017

A combination of garlic, mullein, calendula, st. johns wort and olive oil is as effective as an anesthetic drug for the management of acute otitis media-associated pain. Jul 01, 2001

A combination of Hypericum perforatum (St. johns wort) and Vitex agnus-castus improves PMS-like symptoms in late-perimenopausal women. Sep 01, 2009

Achillea millefolium and Hypericum perforatum ointments reduce perineal pain level, redness, edema and ecchymosis of episiotomy wound.Dec 31, 2017

Dandelion, St. Johns Wort, Melissa (Lemonbalm), Marigold, and Fennel have therpaeutic effects in treating colitis and diarrhea syndrome. Jan 01, 1981

Hypericin, a compound found within St. John's wort, may have therapeutic value in the treatment of mesothelioma. Oct 01, 1990

Hypericum (st. john's wort) has therapeutic value in the treatment of seasonal affective disorder.Sep 01, 1997

Hypericum perforatum (syn. St.John's wort) improves hot flashes and quality of life in perimenopausal women. Feb 01, 2005

Naturopathic treatment for ear pain is demonstrated superior to antibiotic treatment.May 01, 2003

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract.Nov 30, 2018

St John's Wort is modestly effective in the short-term treatment of irritability in some patients with autistic disorder.Jan 01, 1997

St. John's Wort in combination with photodynamic therapy demonstrates therapeutic effects in Actinic Keratosis, Basal Cell Carcinoma and Bowen's disease. May 01, 2008

St. John's wort may contribute to easing physical dependence and withdrawal syndrome associated with heroin addiction. Mar 01, 2007

St. Johns Wort may reduce the withdrawal signs associated with nicotine addiction. Oct 01, 2007

Subchronic treatment with St John's wort produces a positive shift in emotional processing in healthy volunteers.Nov 27, 2018

Topical application of H. perforatum is safe and can facilitate cesarean wound healing and minimize formation of scar, pain and itching.Jan 01, 2010

Topical St. John's wort cream may improve Atopical Dermatitis. Jan 01, 2003

Treatment of osteomyelitis in the feet of diabetic patients by photodynamic antimicrobial chemotherapy.Jan 31, 2009

Treatment with small dosages of H. perforatum has a positive effect on the capacity of short-term verbal memory.Oct 30, 2018

Hypericum perforatum may be a promising therapeutic option for trigeminal neuralgia.Jan 31, 2017

St. John's wort oily extract may be suggested as a cost-effective option for the prevention or treatment of pressure sores in ICU patients.Jan 19, 2017

St. Johns Wort extract is a potential alternative to phenobarbital in patients with Crigler-Najjar syndrome type II.Dec 20, 2015

A marine-herbal combination containing prawns, celery seed and st. john's wort has therapeutic value in an animal model of multiple sclerosis.Aug 01, 2008

An extract of St. Johns Wort has significant therapeutic efficacy for mice infected with influenza A virus.Jan 31, 2012

Application of Hypericum perforatum may be recommended as it was effective on wound healing in diabetic rats.Jan 31, 2017

Aqueous St. Johns Wort reduced the serum lipid profiles of rats in terms of LDL-CH.Apr 30, 2016

Both curcumin and Hypericum perforatum oil are effective in burn wound healing.Dec 31, 2019

Effectiveness of Hypericum perforatum extract in the treatment of corrosive esophageal burns.May 16, 2021

Extracts of Hypericum perforatum (St. John's wort) heal gastric lesions induced in rats. Jun 01, 2009

Hyperforin could promote functional recovery when delivered in the later phases of stroke recovery.Aug 31, 2016

Hyperforin, a compound found with St. Johns wort, may have a therapeutic role in reducing pleurisy in a rat model. Aug 01, 2009

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Hypericin, a compound found within St. John's wort, in combination with photodynamic therapy induces cell death in nasopharyngeal cancer. Nov 01, 2003

Hypericum perforatum can ameliorate estrogen deficiency-induced hypercholesterolemia.Feb 28, 2021

Hypericum perforatum extract has neuroprotection actions against aluminum chloride-induced Alzheimer's disease like pathology.May 12, 2017

Hypericum Perforatum is protective against acute renal Ischemia/reperfusion injury. Oct 31, 2017

Hypericum perforatum L is a promising chemopreventive agent.Jun 30, 2021

Hypericum perforatum may improve anxiety-like behaviour and offer brain protection by modulation of oxidative stress and inflammation.Sep 30, 2018

Hypericum perforatum reduces paracetamol-induced hepatotoxicity and lethality.Jun 30, 2015

Hypericum perforatum supplementation could be useful in sciatic nerve injury.May 15, 2017

Hyperoside alleviates epilepsy-induced neuronal damage.Jul 14, 2020

Natural plant extracts from oak bark, St. john's work leaves and pine buds may have therapeutic activity in supporting natural immunity from Staphylococcus aureus and Bordetella pertussis.Apr 01, 1986

Oral St. John's wort has more positive effects on problematic wounds compared with topical St. John's wortJan 19, 2017

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity. May 01, 2008

Sea buckthorn and St. John's wort oil may be a promising alternative for the treatment of endometriosis.Nov 30, 2016

St John's-wort has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.Dec 31, 2014

St. John's Wort and feverfew extracts may become new therapeutic perspectives for painful diabetic peripheral neuropathy. Dec 31, 2013

St. John's wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells.Dec 02, 2015

St. John's wort extract had chemopreventive properties against colorectal cancer through attenuation of pro-inflammatory processes.Aug 31, 2015

St. John's wort extract is twice as effective as ibuprofen as an analgesic in an animal model of pain. Jul 01, 2004

St. John's wort is as effective as clonoidine in reducing the symptoms of optiate withdrawal in rats.Jun 01, 2004

St. John's wort may diminish deleterious effects of aging on spatial memory. Sep 20, 2005

St. John's wort may lessen urinary incontinence in depressed patients. Jul 01, 2004

St. John's wort reduces symptoms of alcohol withdrawal in rats. Oct 01, 2006

St. Johns Wort attenuates nicotine withdrawal signs in mice.Sep 01, 2003

St. Johns Wort may be therapeutic in the treatment of nicotine addiction. Jul 07, 2009

St. Johns Wort may have a renoprotective effect against diabetic nephropathy.Jan 11, 2017

The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats.Aug 31, 2018

The healing effects of St. John's Wort on experimental alkaline corrosive eosephageal and stomach burns.Apr 30, 2020

The protective effect of hypericin on postpartum depression.Jan 27, 2022

These findings reveal the beneficial effect of H. perforatum via attenuation of DNA fragmentation, astrogliosis, inflammation, and oxidative stress.Jun 28, 2015

A marine-herbal combination containing prawns, celery seed and st. john's wort has therapeutic value in multiple sclerosis. Jun 01, 2010

A review of effective medicinal plants in the treatment of the cyclic mastalgia.Aug 31, 2019

A review of herbal therapy in multiple sclerosis.Oct 31, 2018

A review of natural antioxidants in the management of Parkinson's disease.Mar 26, 2021

A variety of herbs exhibit uterotonic properties.Mar 17, 2010

Adipogenesis inhibitory activity of hypersampsone P from Hypericum subsessileMay 31, 2020

Anti-quorum sensing and anti-biofilm activities of Hypericum perforatum extracts against Pseudomonas aeruginosa.May 09, 2019

Anti-tumor activity of Hypericum perforatum L. and hyperforin through modulation of inflammatory signalling, ROS generation and proton dynamics. Dec 27, 2020

Antimicrobial and antibiofilm activity of polyurethane/Hypericum perforatum extract composite.Jan 31, 2019

Antiproliferative activity of Hypericum perforatum, Achillea millefolium, and Aloe vera in interaction with the prostatic activity of CD82. Sep 30, 2019

St. Johns Wort

View the Evidence:
110 Abstracts with St. Johns Wort Research