St. Johns Wort

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100 Diseases Researched for St. Johns Wort
NameACCKFocus
Wound Healing629Locked
Depression623Locked
Depression120Locked
Ear Infection220Locked
Perimenopausal Syndrome220Locked
Opiate Addiction/Withdrawal212Locked
Actinic Keratosis110Locked
Atopic Dermatitis110Locked
Autism110Locked
Basal Cell Carcinoma110Locked
Bowen's Disease110Locked
Cesarean Section110Locked
Chemotherapy and Radiation Toxicity110Locked
Chemotherapy-Induced Toxicity: Cisplatin110Locked
Colitis110Locked
Diarrhea110Locked
Episiotomy110Locked
Head and Neck Cancer110Locked
Heroin Addication/Withdrawal110Locked
Hot Flash110Locked
Memory Disorders110Locked
Mesothelioma110Locked
Otitis media110Locked
Quality of Life: Poor110Locked
Seasonal Affective Disorder110Locked
Tobacco Addiction/Withdrawal110Locked
Diabetic Complications48Locked
Inflammation46Locked
Multiple Sclerosis46Locked
HIV Infections55Locked
Oxidative Stress35Locked
Burns24Locked
Smoking Cessation: Nicotine Addiction24Locked
Wound Healing: Delayed24Locked
Aluminum Toxicity 23Locked
Bedsore13Locked
Brain: Oxidative Stress23Locked
Cancer Metastasis33Locked
Cancers: All33Locked
Crigler-Najjar syndrome13Locked
Hyperbilirubinemia: Hereditary13Locked
Nasopharyngeal Cancer23Locked
Parkinson's Disease23Locked
Trigeminal Neuralgia13Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Aging: Brain 12Locked
Alcohol Withdrawal12Locked
Alzheimer's Disease12Locked
Anxiety12Locked
Brain Inflammation 12Locked
Chemotherapy-Induced Toxicity: Bleomycin12Locked
Colorectal Cancer12Locked
Colorectal Cancer: Prevention 12Locked
Cystic Fibrosis12Locked
Diabetic Nephropathy12Locked
Diabetic Neuropathy12Locked
Endometriosis12Locked
Epilepsy12Locked
Excitotoxicity 12Locked
Gastric Ulcer12Locked
Hypercholesterolemia12Locked
Hyperlipidemia12Locked
Incontinence12Locked
Incontinence: Urinary12Locked
Influenza A12Locked
Ischemia12Locked
Kidney Damage12Locked
Leukemia22Locked
Leukemia: Chronic Lymphocytic Leukemia (CLL)22Locked
Lipid Peroxidation12Locked
Memory Loss12Locked
Pain12Locked
Pertussis12Locked
Pleurisy12Locked
Pulmonary Fibrosis12Locked
Sciatic Nerve Crush Injury12Locked
Staphylococcus aureus infection22Locked
Stroke: Attenuation/Recovery 12Locked
Whooping Cough12Locked
Breast Cancer11Locked
Cancers: Drug Resistant11Locked
Chemotherapy-Induced Toxicity: Oxaliplatin11Locked
Chronic Pain11Locked
Colon Cancer11Locked
Coronavirus Infection11Locked
Cytomegalovirus Infections11Locked
Diabetes Mellitus: Type 111Locked
Diabetes Mellitus: Type 1: Prevention11Locked
Glioblastoma11Locked
Leukemia: B-Cell11Locked
Mastalgia11Locked
Obesity11Locked
Postnatal Depression11Locked
Premenstrual syndrome11Locked
Prostate Cancer11Locked
Pseudomonas aeruginosa11Locked
Scars11Locked
Uterus: Contraction/Expulsion Disorders11Locked
Cortisol: High10Locked
Pancreatic Cancer10Locked
43 Pharmacological Actions Researched for St. Johns Wort
NameACCKFocus
Antidepressive Agents542Locked
Neuroprotective Agents924Locked
Anti-Inflammatory Agents1219Locked
Analgesics518Locked
Antioxidants1117Locked
Chemoprotective Agents211Locked
Radioprotective110Locked
Apoptotic67Locked
Antiproliferative 66Locked
Immunomodulatory46Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor36Locked
Antiviral Agents45Locked
Hypolipidemic24Locked
Interleukin-6 Downregulation24Locked
Renoprotective24Locked
Anti-Angiogenic33Locked
Anti-metastatic33Locked
Chemopreventive23Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor23Locked
Anti-Anxiety Agents12Locked
Anti-Apoptotic12Locked
Anti-Bacterial Agents22Locked
Anti-Tumor12Locked
Anticarcinogenic Agents12Locked
Anticholesteremic Agents12Locked
Autophagy Inhibitors12Locked
Excitatory Amino Acid Agonists12Locked
Gastrointestinal Agents12Locked
Gastroprotective12Locked
Hepatoprotective12Locked
Interleukin-1 alpha downregulation12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-10 downregulation12Locked
Interleukin-17 downregulation12Locked
Vascular Endothelial Growth Factor Inhibitors12Locked
Anti-HIV Agents11Locked
Antinoceceptive 11Locked
Chemotherapeutic11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
NF-kappaB Inhibitor11Locked
Pancreato Protective Agents11Locked
Quorum Sensing Inhibition11Locked
Uterotonic11Locked

View the Evidence:
112 Abstracts with St. Johns Wort Research

[+]

St John's wort has comparable efficacy and safety when compared to SSRIs in patients with mild-to-moderate depression.Jan 02, 2017

Pubmed Data : J Affect Disord. 2017 Jan 3 ;210:211-221. Epub 2017 Jan 3. PMID: 28064110
Article Published Date : Jan 02, 2017
Study Type : Meta Analysis
Additional Links
Substances : St. Johns Wort
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Antidepressive Agents, Depression, Plant Extracts, St. Johns Wort
[+]

A combination of garlic, mullein, calendula, st. johns wort and olive oil is as effective as an anesthetic drug for the management of acute otitis media-associated pain. Jul 01, 2001

Pubmed Data : Arch Pediatr Adolesc Med. 2001 Jul;155(7):796-9. PMID: 11434846
Article Published Date : Jul 01, 2001
Study Type : Human Study
Additional Links
Substances : Calendula, Garlic, Mullein, Olive, St. Johns Wort
Diseases : Ear Infection, Otitis media
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
[+]

A combination of Hypericum perforatum (St. johns wort) and Vitex agnus-castus improves PMS-like symptoms in late-perimenopausal women. Sep 01, 2009

Pubmed Data : J Altern Complement Med. 2009 Sep;15(9):1045-8. PMID: 19757982
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : St. Johns Wort, Vitex Agnus
Diseases : Perimenopausal Syndrome
[+]

Achillea millefolium and Hypericum perforatum ointments reduce perineal pain level, redness, edema and ecchymosis of episiotomy wound.Dec 31, 2017

Pubmed Data : J Matern Fetal Neonatal Med. 2018 Jan ;31(1):63-69. Epub 2017 Feb 23. PMID: 28027682
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : St. Johns Wort, Yarrow
Diseases : Episiotomy, Wound Healing
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Dandelion, St. Johns Wort, Melissa (Lemonbalm), Marigold, and Fennel have therpaeutic effects in treating colitis and diarrhea syndrome. Jan 01, 1981

Pubmed Data : Vutr Boles. 1981;20(6):51-4. PMID: 7336706
Article Published Date : Jan 01, 1981
Study Type : Human Study
Additional Links
Substances : Dandelion , Fennel, Marigold, Melissa (Lemonbalm), St. Johns Wort
Diseases : Colitis, Diarrhea
Additional Keywords : Plant Extracts
[+]

Efficacy and safety of co-administered St. John's wort and Ginkgo biloba extracts in patients with subjective tinnitus.May 02, 2023

Pubmed Data : J Clin Med. 2023 May 3 ;12(9). Epub 2023 May 3. PMID: 37176699
Article Published Date : May 02, 2023
Study Type : Human Study
Additional Links
Substances : Ginkgo biloba, St. Johns Wort
Diseases : Tinnitus
[+]

Hypericin, a compound found within St. John's wort, may have therapeutic value in the treatment of mesothelioma. Oct 01, 1990

Pubmed Data : J Ethnopharmacol. 1990 Oct;30(3):295-300. PMID: 9002247
Article Published Date : Oct 01, 1990
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Mesothelioma
Therapeutic Actions : Photodynamic therapy
[+]

Hypericum (st. john's wort) has therapeutic value in the treatment of seasonal affective disorder.Sep 01, 1997

Pubmed Data : Pharmacopsychiatry. 1997 Sep;30 Suppl 2:89-93. PMID: 17151164
Article Published Date : Sep 01, 1997
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Seasonal Affective Disorder
[+]

Hypericum perforatum (syn. St.John's wort) improves hot flashes and quality of life in perimenopausal women. Feb 01, 2005

Pubmed Data : J Adv Nurs. 2005 Feb;49(3):234-44. PMID: 19194342
Article Published Date : Feb 01, 2005
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Hot Flash, Perimenopausal Syndrome, Quality of Life: Poor
[+]

Naturopathic treatment for ear pain is demonstrated superior to antibiotic treatment.May 01, 2003

Pubmed Data : Pediatrics. 2003 May;111(5 Pt 1):e574-9. PMID: 12728112
Article Published Date : May 01, 2003
Study Type : Human Study
Additional Links
Substances : Calendula, Garlic, Lavender, Mullein, Olive, St. Johns Wort, Vitamin E
Diseases : Ear Infection
Additional Keywords : Natural Substances Versus Drugs
[+]

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Pubmed Data : Med Oncol. 2017 Feb ;34(2):30. Epub 2017 Jan 18. PMID: 28101834
Article Published Date : Jan 31, 2017
Study Type : Human Study
Additional Links
Substances : Neem, St. Johns Wort
Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Cisplatin, Head and Neck Cancer
Pharmacological Actions : Chemoprotective Agents, Radioprotective
[+]

Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract.Nov 30, 2018

Pubmed Data : Panminerva Med. 2018 Dec ;60(4):156-160. Epub 2018 Jul 10. PMID: 29991209
Article Published Date : Nov 30, 2018
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

St John's Wort is modestly effective in the short-term treatment of irritability in some patients with autistic disorder.Jan 01, 1997

Pubmed Data : Oncol Res. 1997;9(1):31-9. PMID: 19274686
Article Published Date : Jan 01, 1997
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Autism
[+]

St. John's Wort in combination with photodynamic therapy demonstrates therapeutic effects in Actinic Keratosis, Basal Cell Carcinoma and Bowen's disease. May 01, 2008

Pubmed Data : Photochem Photobiol. 2008 May-Jun;84(3):779-85. Epub 2008 Jan 7 PMID: 18179625
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Actinic Keratosis, Basal Cell Carcinoma, Bowen's Disease
[+]

St. John's wort may contribute to easing physical dependence and withdrawal syndrome associated with heroin addiction. Mar 01, 2007

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2007 Mar;131(1):61-7. Epub 2006 Nov 17. PMID: 19067385
Article Published Date : Mar 01, 2007
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Heroin Addication/Withdrawal, Opiate Addiction/Withdrawal
[+]

St. Johns Wort may reduce the withdrawal signs associated with nicotine addiction. Oct 01, 2007

Pubmed Data : Phytomedicine. 2007 Oct;14(10):645-51. Epub 2007 Aug 6. PMID: 17689233
Article Published Date : Oct 01, 2007
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Tobacco Addiction/Withdrawal
[+]

Subchronic treatment with St John's wort produces a positive shift in emotional processing in healthy volunteers.Nov 27, 2018

Pubmed Data : J Psychopharmacol. 2018 Nov 28:269881118812101. Epub 2018 Nov 28. PMID: 30484733
Article Published Date : Nov 27, 2018
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Topical application of H. perforatum is safe and can facilitate cesarean wound healing and minimize formation of scar, pain and itching.Jan 01, 2010

Pubmed Data : J Altern Complement Med. 2010 Jan;16(1):113-7. PMID: 20064022
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Cesarean Section, Wound Healing
[+]

Topical St. John's wort cream may improve Atopical Dermatitis. Jan 01, 2003

Pubmed Data : Phytomedicine. 2003;10 Suppl 4:31-7. PMID: 12807340
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Atopic Dermatitis
[+]

Treatment of osteomyelitis in the feet of diabetic patients by photodynamic antimicrobial chemotherapy.Jan 31, 2009

Pubmed Data : Photomed Laser Surg. 2009 Feb ;27(1):145-50. PMID: 19196112
Article Published Date : Jan 31, 2009
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Diabetic Complications, Osteomyelitis
Therapeutic Actions : Photodynamic therapy
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Phytotherapy
[+]

Treatment with small dosages of H. perforatum has a positive effect on the capacity of short-term verbal memory.Oct 30, 2018

Pubmed Data : Psychopharmacology (Berl). 2018 Oct 31. Epub 2018 Oct 31. PMID: 30382352
Article Published Date : Oct 30, 2018
Study Type : Human Study
Additional Links
Substances : St. Johns Wort
Diseases : Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Hypericum perforatum may be a promising therapeutic option for trigeminal neuralgia.Jan 31, 2017

Pubmed Data : Complement Ther Med. 2017 Feb ;30:36-39. Epub 2016 Nov 17. PMID: 28137525
Article Published Date : Jan 31, 2017
Study Type : Human: Case Report
Additional Links
Substances : St. Johns Wort
Diseases : Trigeminal Neuralgia
Pharmacological Actions : Analgesics
[+]

St. John's wort oily extract may be suggested as a cost-effective option for the prevention or treatment of pressure sores in ICU patients.Jan 19, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jan 20 ;196:236-241. Epub 2016 Dec 21. PMID: 28011162
Article Published Date : Jan 19, 2017
Study Type : Human: Case Report
Additional Links
Substances : St. Johns Wort
Diseases : Bedsore, Wound Healing
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

St. Johns Wort extract is a potential alternative to phenobarbital in patients with Crigler-Najjar syndrome type II.Dec 20, 2015

Pubmed Data : Br J Clin Pharmacol. 2015 Dec 21. Epub 2015 Dec 21. PMID: 26692114
Article Published Date : Dec 20, 2015
Study Type : Human: Case Report
Additional Links
Substances : St. Johns Wort
Diseases : Crigler-Najjar syndrome, Hyperbilirubinemia: Hereditary
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
[+]

A marine-herbal combination containing prawns, celery seed and st. john's wort has therapeutic value in an animal model of multiple sclerosis.Aug 01, 2008

Pubmed Data : Phytother Res. 2008 Aug;22(8):1083-6. PMID: 18570265
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Celery seed, Penaeus Latisculatus (prawn), St. Johns Wort
Diseases : Multiple Sclerosis
[+]

An extract of St. Johns Wort has significant therapeutic efficacy for mice infected with influenza A virus.Jan 31, 2012

Pubmed Data : Can J Physiol Pharmacol. 2012 Feb ;90(2):123-30. Epub 2012 Jan 20. PMID: 22260349
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Influenza A
Pharmacological Actions : Antiviral Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Application of Hypericum perforatum may be recommended as it was effective on wound healing in diabetic rats.Jan 31, 2017

Pubmed Data : Wounds. 2017 Feb ;29(2):E10-E17. PMID: 28272017
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Diabetic Complications, Wound Healing
[+]

Aqueous St. Johns Wort reduced the serum lipid profiles of rats in terms of LDL-CH.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Cardiovasc Med. 2016 May ;5(2):e31326. Epub 2016 Mar 5. PMID: 26949689
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Hyperlipidemia, Lipid Peroxidation
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
Additional Keywords : Plant Extracts
[+]

Both curcumin and Hypericum perforatum oil are effective in burn wound healing.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6462956. Epub 2020 Feb 13. PMID: 32148546
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin, St. Johns Wort
Diseases : Burns, Wound Healing
[+]

Effectiveness of Hypericum perforatum extract in the treatment of corrosive esophageal burns.May 16, 2021

Pubmed Data : J Invest Surg. 2021 May 17:1-6. Epub 2021 May 17. PMID: 33998353
Article Published Date : May 16, 2021
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Burns
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Extracts of Hypericum perforatum (St. John's wort) heal gastric lesions induced in rats. Jun 01, 2009

Pubmed Data : Saudi Med J. 2009 Jun;30(6):750-4. PMID: 19526154
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Gastric Ulcer
Additional Keywords : Natural Substances Versus Drugs, Ranitidine
[+]

Hyperforin could promote functional recovery when delivered in the later phases of stroke recovery.Aug 31, 2016

Pubmed Data : Brain Res. 2016 Sep 1 ;1646:504-13. Epub 2016 Jun 17. PMID: 27328426
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hyperforin, St. Johns Wort
Diseases : Stroke: Attenuation/Recovery
Pharmacological Actions : Interleukin-17 downregulation, Neuroprotective Agents
[+]

Hyperforin, a compound found with St. Johns wort, may have a therapeutic role in reducing pleurisy in a rat model. Aug 01, 2009

Pubmed Data : Cell Mol Life Sci. 2009 Aug;66(16):2759-71. Epub 2009 Jul 5. PMID: 19579006
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Pleurisy
[+]

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Pubmed Data : J Pharmacol Exp Ther. 2007 May;321(2):492-500. Epub 2007 Feb 8. PMID: 17289834
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Cystic Fibrosis, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Hypericin, a compound found within St. John's wort, in combination with photodynamic therapy induces cell death in nasopharyngeal cancer. Nov 01, 2003

Pubmed Data : Int J Oncol. 2003 Nov;23(5):1401-5. PMID: 14532982
Article Published Date : Nov 01, 2003
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Nasopharyngeal Cancer
Therapeutic Actions : Light Therapy
Pharmacological Actions : Anti-Tumor, Antioxidants, Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Hypericum perforatum can ameliorate estrogen deficiency-induced hypercholesterolemia.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Mar ;135:111131. Epub 2020 Dec 28. PMID: 33383372
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Hypercholesterolemia
Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic
[+]

Hypericum perforatum extract has neuroprotection actions against aluminum chloride-induced Alzheimer's disease like pathology.May 12, 2017

Pubmed Data : Biomed Pharmacother. 2017 May 13 ;91:931-937. Epub 2017 May 13. PMID: 28514831
Article Published Date : May 12, 2017
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Aluminum Toxicity , Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum Chloride
[+]

Hypericum Perforatum is protective against acute renal Ischemia/reperfusion injury. Oct 31, 2017

Pubmed Data : Ren Fail. 2017 Nov ;39(1):385-391. PMID: 28209087
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Renoprotective
[+]

Hypericum perforatum L is a promising chemopreventive agent.Jun 30, 2021

Pubmed Data : Arch Oral Biol. 2021 Jul ;127:105139. Epub 2021 Apr 30. PMID: 33964648
Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Chemopreventive
Additional Keywords : Plant Extracts
[+]

Hypericum perforatum may improve anxiety-like behaviour and offer brain protection by modulation of oxidative stress and inflammation.Sep 30, 2018

Pubmed Data : J Physiol Pharmacol. 2018 Oct ;69(5). Epub 2019 Jan 21. PMID: 30683830
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Anxiety, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
Additional Keywords : Plant Extracts
[+]

Hypericum perforatum nanoemulsion mitigates cisplatin-induced chemobrain.Feb 07, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxics. 2023 Feb 8 ;11(2). Epub 2023 Feb 8. PMID: 36851034
Article Published Date : Feb 07, 2023
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Brain Inflammation , Chemobrain, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Hypericum perforatum reduces paracetamol-induced hepatotoxicity and lethality.Jun 30, 2015

Pubmed Data : Phytother Res. 2015 Jul ;29(7):1097-101. Epub 2015 Apr 8. PMID: 25851311
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hypericum perforatum supplementation could be useful in sciatic nerve injury.May 15, 2017

Pubmed Data : J Pharm Pharmacol. 2017 May 16. Epub 2017 May 16. PMID: 28508406
Article Published Date : May 15, 2017
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Sciatic Nerve Crush Injury
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Hyperoside alleviates epilepsy-induced neuronal damage.Jul 14, 2020

Pubmed Data : J Ethnopharmacol. 2020 Jul 15 ;257:112884. Epub 2020 Apr 18. PMID: 32311482
Article Published Date : Jul 14, 2020
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Epilepsy
Pharmacological Actions : Antioxidants, Autophagy Inhibitors, Neuroprotective Agents
[+]

Natural plant extracts from oak bark, St. john's work leaves and pine buds may have therapeutic activity in supporting natural immunity from Staphylococcus aureus and Bordetella pertussis.Apr 01, 1986

Pubmed Data : Zh Mikrobiol Epidemiol Immunobiol. 1986 Apr(4):71-5. PMID: 3012909
Article Published Date : Apr 01, 1986
Study Type : Animal Study
Additional Links
Substances : Oak, Pine Buds, St. Johns Wort
Diseases : Pertussis, Whooping Cough
Pharmacological Actions : Immunomodulatory
Additional Keywords : Plant Extracts
[+]

Oral St. John's wort has more positive effects on problematic wounds compared with topical St. John's wortJan 19, 2017

Pubmed Data : J Invest Surg. 2017 Jan 20:1-9. Epub 2017 Jan 20. PMID: 28107097
Article Published Date : Jan 19, 2017
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Diabetic Complications, Wound Healing
Additional Keywords : Plant Extracts
[+]

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity. May 01, 2008

Pubmed Data : Neurotox Res. 2008 May-Jun;13(3-4):265-79. PMID: 18522906
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Apigenin, Kaempferol, Quercetin, St. Johns Wort
Diseases : Excitotoxicity
Pharmacological Actions : Excitatory Amino Acid Agonists, Neuroprotective Agents
[+]

Sea buckthorn and St. John's wort oil may be a promising alternative for the treatment of endometriosis.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Taiwan J Obstet Gynecol. 2016 Dec ;55(6):786-790. PMID: 28040120
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Sea buckthorn, St. Johns Wort
Diseases : Endometriosis
Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

St John's-wort has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:245328. Epub 2015 Aug 31. PMID: 26417372
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Diabetic Complications, Wound Healing: Delayed
[+]

St. John's Wort and feverfew extracts may become new therapeutic perspectives for painful diabetic peripheral neuropathy. Dec 31, 2013

Pubmed Data : Fitoterapia. 2014 Jan ;92:23-33. Epub 2013 Oct 12. PMID: 24125916
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Feverfew, St. Johns Wort
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy, Plant Extracts
[+]

St. John's wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells.Dec 02, 2015

Pubmed Data : J Immunotoxicol. 2015 Dec 3:1-11. Epub 2015 Dec 3. PMID: 26634391
Article Published Date : Dec 02, 2015
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Multiple Sclerosis
Pharmacological Actions : Immunomodulatory
[+]

St. John's wort extract had chemopreventive properties against colorectal cancer through attenuation of pro-inflammatory processes.Aug 31, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Sep ;8(9):786-95. Epub 2015 Jun 11. PMID: 26069204
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Dose Response, Plant Extracts
[+]

St. John's wort extract is twice as effective as ibuprofen as an analgesic in an animal model of pain. Jul 01, 2004

Pubmed Data : Pak J Pharm Sci. 2004 Jul;17(2):13-9. PMID: 16414593
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Pain
Pharmacological Actions : Analgesics
Additional Keywords : Ibuprofen Alternatives, Superiority of Natural Substances versus Drugs
[+]

St. John's wort is as effective as clonoidine in reducing the symptoms of optiate withdrawal in rats.Jun 01, 2004

Pubmed Data : Cancer Res. 2004 Jun 1;64(11):3757-60. PMID: 19370548
Article Published Date : Jun 01, 2004
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Opiate Addiction/Withdrawal
Additional Keywords : Natural Substances Versus Drugs
[+]

St. John's wort may diminish deleterious effects of aging on spatial memory. Sep 20, 2005

Pubmed Data : AAPS PharmSciTech. 2005 Sep 20;6(1):E74-82. PMID: 20361314
Article Published Date : Sep 20, 2005
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Aging: Brain , Memory Loss
Pharmacological Actions : Neuroprotective Agents
[+]

St. John's wort may lessen urinary incontinence in depressed patients. Jul 01, 2004

Pubmed Data : Urology. 2004 Jul;64(1):168-72. PMID: 15245964
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Incontinence, Incontinence: Urinary
[+]

St. John's wort reduces symptoms of alcohol withdrawal in rats. Oct 01, 2006

Pubmed Data : Fundam Clin Pharmacol. 2006 Oct;20(5):481-8. PMID: 16968419
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Alcohol Withdrawal
[+]

St. Johns Wort attenuates nicotine withdrawal signs in mice.Sep 01, 2003

Pubmed Data : Psychopharmacology (Berl). 2003 Sep;169(2):186-9. Epub 2003 Apr 29. PMID: 12719964
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Smoking Cessation: Nicotine Addiction
Additional Keywords : Plant Extracts
[+]

St. Johns Wort may be therapeutic in the treatment of nicotine addiction. Jul 07, 2009

Pubmed Data : Phytother Res. 2009 Jul 7. PMID: 19585471
Article Published Date : Jul 07, 2009
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Smoking Cessation: Nicotine Addiction
[+]

St. Johns Wort may have a renoprotective effect against diabetic nephropathy.Jan 11, 2017

Pubmed Data : Clin Exp Pharmacol Physiol. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28079268
Article Published Date : Jan 11, 2017
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Oral Res. 2018 Sep ;52(3):143-149. Epub 2018 Sep 1. PMID: 30775718
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Diabetic Complications, Wound Healing: Delayed
[+]

The healing effects of St. John's Wort on experimental alkaline corrosive eosephageal and stomach burns.Apr 30, 2020

Pubmed Data : Ulus Travma Acil Cerrahi Derg. 2020 May ;26(3):373-383. PMID: 32436985
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Burns
Pharmacological Actions : Gastroprotective
[+]

The protective effect of hypericin on postpartum depression.Jan 27, 2022

Pubmed Data : Int Immunopharmacol. 2022 Jan 28 ;105:108560. Epub 2022 Jan 28. PMID: 35101848
Article Published Date : Jan 27, 2022
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Depression: Postpartum
Therapeutic Actions : Photodynamic therapy
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
[+]

These findings reveal the beneficial effect of H. perforatum via attenuation of DNA fragmentation, astrogliosis, inflammation, and oxidative stress.Jun 28, 2015

Pubmed Data : Cell Mol Neurobiol. 2015 Jun 29. Epub 2015 Jun 29. PMID: 26119304
Article Published Date : Jun 28, 2015
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Brain: Oxidative Stress, Brain Inflammation , Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

A marine-herbal combination containing prawns, celery seed and st. john's wort has therapeutic value in multiple sclerosis. Jun 01, 2010

Pubmed Data : Chin J Integr Med. 2010 Jun;16(3):270-1. Epub 2010 Aug 8. PMID: 20694784
Article Published Date : Jun 01, 2010
Study Type : Review
Additional Links
Substances : Celery seed, Penaeus Latisculatus (prawn), St. Johns Wort
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

A review of effective medicinal plants in the treatment of the cyclic mastalgia.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2019 Sep ;22(3):131-139. Epub 2019 Sep 30. PMID: 31673442
Article Published Date : Aug 31, 2019
Study Type : Review
Additional Links
Substances : Chaste Tree (Chasteberry), Curcumin, Ginkgo biloba, Nigella sativa (aka Black Seed), St. Johns Wort, Sweet Orange, Wheat Germ
Diseases : Mastalgia
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants
[+]

A review of herbal therapy in multiple sclerosis.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharm Bull. 2018 Nov ;8(4):575-590. Epub 2018 Nov 29. PMID: 30607330
Article Published Date : Oct 31, 2018
Study Type : Review
Additional Links
Substances : Cannabis, Cranberry, Frankincense, Ginger, Ginkgo biloba, Ginseng, Grape, Kava Kava, Nigella sativa (aka Black Seed), Saffron, St. Johns Wort, Turmeric, Valerian
Diseases : Multiple Sclerosis
[+]

A review of natural antioxidants in the management of Parkinson's disease.Mar 26, 2021

Pubmed Data : J Integr Med. 2021 Mar 27. Epub 2021 Mar 27. PMID: 33863692
Article Published Date : Mar 26, 2021
Study Type : Review
Additional Links
Substances : Ashwagandha, Curcumin, Ginkgo biloba, Hydroxytyrosol, St. Johns Wort
Diseases : Brain: Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

A variety of herbs exhibit uterotonic properties.Mar 17, 2010

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):362-365. Epub 2009 Dec 24. PMID: 7314446
Article Published Date : Mar 17, 2010
Study Type : In Vitro Study
Additional Links
Substances : Calendula, Celosia cristata (cockscomb), Chamomile, Comfrey, Plantain, Shepherds purse , St. Johns Wort
Diseases : Uterus: Contraction/Expulsion Disorders
Pharmacological Actions : Uterotonic
Additional Keywords : Plant Extracts
[+]

Adipogenesis inhibitory activity of hypersampsone P from Hypericum subsessileMay 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nat Prod Bioprospect. 2020 Jun ;10(3):163-170. Epub 2020 May 23. PMID: 32447748
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Anti-quorum sensing and anti-biofilm activities of Hypericum perforatum extracts against Pseudomonas aeruginosa.May 09, 2019

Pubmed Data : J Ethnopharmacol. 2019 May 10 ;235:293-300. Epub 2019 Feb 11. PMID: 30763694
Article Published Date : May 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Quorum Sensing Inhibition
[+]

Anti-tumor activity of Hypericum perforatum L. and hyperforin through modulation of inflammatory signalling, ROS generation and proton dynamics. Dec 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Dec 28 ;10(1). Epub 2020 Dec 28. PMID: 33379141
Article Published Date : Dec 27, 2020
Study Type : Review
Additional Links
Substances : Hyperforin, St. Johns Wort
Diseases : Cancers: All, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemotherapeutic
[+]

Antimicrobial and antibiofilm activity of polyurethane/Hypericum perforatum extract composite.Jan 31, 2019

Pubmed Data : Bioorg Chem. 2019 Feb ;82:224-228. Epub 2018 Aug 11. PMID: 30342304
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Antiproliferative activity of Hypericum perforatum, Achillea millefolium, and Aloe vera in interaction with the prostatic activity of CD82. Sep 30, 2019

Pubmed Data : Rep Biochem Mol Biol. 2019 Oct ;8(3):260-268. PMID: 32274398
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera, St. Johns Wort, Yarrow
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Selective Antiproliferation
[+]

Antiproliferative effects of St. John's Wort, its derivatives, and other Hypericum species in hematologic malignancies.Dec 24, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Dec 25 ;22(1). Epub 2020 Dec 25. PMID: 33375664
Article Published Date : Dec 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Plant Extracts
[+]

Chemical composition and immunomodulatory activity of Hypericum perforatum essential oils.Jun 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Jun 17 ;10(6). Epub 2020 Jun 17. PMID: 32560389
Article Published Date : Jun 16, 2020
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Pharmacological Actions : Immunomodulatory
Additional Keywords : Essential Oils
[+]

Cytotoxic activities of Hypericum perforatum L. extracts against 2D and 3D cancer cell models.May 31, 2021

Pubmed Data : Cytotechnology. 2021 Jun ;73(3):373-389. Epub 2021 Apr 1. PMID: 34149173
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Cancers: All, Cervical Cancer, Lung Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor
[+]

Distinct Hypericum perforatum L. total extracts exert different antitumour activity on erythroleukemic K562 cells.May 21, 2018

Pubmed Data : Phytother Res. 2018 May 22. Epub 2018 May 22. PMID: 29785769
Article Published Date : May 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

H. perforatum could be used as a novel therapeutic strategy for counteracting chemotherapy-induced neuropathy.Apr 30, 2017

Pubmed Data : Z Naturforsch C. 2017 May 1 ;72(5-6):219-226. PMID: 28160544
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Chemotherapy-Induced Toxicity: Oxaliplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

H. perforatum root cultures could be a novel lead system for the treatment of hypertrophic scars.Dec 03, 2018

Pubmed Data : Planta Med. 2018 Dec 4. Epub 2018 Dec 4. PMID: 30513539
Article Published Date : Dec 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Scars
Pharmacological Actions : Antiproliferative
[+]

Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John's wort's flowers.Feb 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Feb 17 ;11(1):3989. Epub 2021 Feb 17. PMID: 33597594
Article Published Date : Feb 16, 2021
Study Type : In Vitro Study, Plant Study
Additional Links
Substances : Flavonoids, Polyphenols, St. Johns Wort
Pharmacological Actions : Antioxidants
[+]

Hyperforin (a fat-soluble compound from St. John's wort) may improve B-cell Chronic Lymphocytic Leukemia. Sep 01, 2006

Pubmed Data : Leukemia. 2006 Sep;20(9):1519-25. Epub 2006 Jun 22. PMID: 16791262
Article Published Date : Sep 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Leukemia: B-Cell, Leukemia: Chronic Lymphocytic Leukemia (CLL)
Additional Keywords : Hyperforin
[+]

Hyperforin acts as an angiogenesis inhibitor.May 15, 1996

Pubmed Data : Spine (Phila Pa 1976). 1996 May 15;21(10):1147-52. PMID: 16320199
Article Published Date : May 15, 1996
Study Type : Commentary
Additional Links
Substances : St. Johns Wort
Diseases : Cancer Metastasis
Pharmacological Actions : Anti-Angiogenic
[+]

Hyperforin and miquelianin from St. John's wort attenuate gene expression in neuronal cells after dexamethasone-induced stress.Jun 30, 2018

Pubmed Data : Planta Med. 2018 Jul ;84(9-10):696-703. Epub 2018 Mar 2. PMID: 29499586
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hyperforin, St. Johns Wort
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Problem Substances : Dexamethasone
[+]

Hyperforin, a bio-active compound of St. John's Wort, is a new inhibitor of angiogenesis targeting several key steps of the process.Dec 10, 2005

Pubmed Data : Int J Cancer. 2005 Dec 10;117(5):775-80. PMID: 15981212
Article Published Date : Dec 10, 2005
Study Type : Review
Additional Links
Substances : St. Johns Wort
Diseases : Cancer Metastasis
Pharmacological Actions : Anti-Angiogenic
[+]

Hyperforin, a compound found with St. Johns wort, have anticancer activity against leukemic cells from patients with B-cell CLL. Mar 01, 2006

Pubmed Data : Leukemia. 2006 Mar;20(3):491-7. PMID: 16424868
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Leukemia: Chronic Lymphocytic Leukemia (CLL)
Pharmacological Actions : Apoptotic
[+]

Hypericin exhibited a dose-dependent cytotoxic effect in the MCF-7 cell line. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2015 ;16:3. Epub 2016 Feb 9. PMID: 26865836
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Dose Response, Natural Substances Versus Drugs
[+]

Hypericin, a compound found within St. John's wort, may have therapeutic value in the treatment of nasopharyngeal cancer with photodynamic therapy. Sep 01, 2006

Pubmed Data : Curr Clin Pharmacol. 2006 Sep;1(3):217-22. PMID: 18666746
Article Published Date : Sep 01, 2006
Study Type : Commentary
Additional Links
Substances : St. Johns Wort
Diseases : Nasopharyngeal Cancer
Therapeutic Actions : Photodynamic therapy
[+]

Hypericum perforatum regulates glutathione redox stress and normalizes Ggt1/Anpep signaling to alleviate OVX-induced kidney dysfunction.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:628651. Epub 2021 Apr 26. PMID: 33981220
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Kidney Damage, Menopausal Syndrome
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease.Feb 13, 2022

Pubmed Data : J Ethnopharmacol. 2022 Feb 14 ;290:115107. Epub 2022 Feb 14. PMID: 35176467
Article Published Date : Feb 13, 2022
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap , Fenugreek, Ginkgo biloba, Lavender, Rosemary, St. Johns Wort, Turmeric
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Natural products for COVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies.Sep 26, 2020

Pubmed Data : Phytother Res. 2020 Sep 27. Epub 2020 Sep 27. PMID: 32985017
Article Published Date : Sep 26, 2020
Study Type : Review
Additional Links
Substances : Echinacea, Garlic, Ginger, Licorice, Nigella sativa (aka Black Seed), St. Johns Wort
Diseases : Coronavirus Infection
Pharmacological Actions : Immunomodulatory
[+]

Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells.Nov 23, 2018

Pubmed Data : Chem Biol Interact. 2018 Nov 24 ;299:15-26. Epub 2018 Nov 24. PMID: 30481499
Article Published Date : Nov 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hyperforin, St. Johns Wort
Diseases : Aluminum Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum
[+]

On the mechanism of action of anti-inflammatory activity of hypericin.Nov 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 22 ;23(12). Epub 2018 Nov 22. PMID: 30467287
Article Published Date : Nov 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Preclinical studies indicate a potential use of St. John's wort in medical pain management.Feb 11, 2017

Pubmed Data : J Ethnopharmacol. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28216196
Article Published Date : Feb 11, 2017
Study Type : Review
Additional Links
Substances : St. Johns Wort
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

Review: antiangogenic effect of selected phytochemicals.Jan 01, 2010

Pubmed Data : Pharmazie. 2010 Jan;65(1):57-63. PMID: 20187580
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Substances : Coptis chinensis, Curcumin, Garlic, Panax Ginseng, Resveratrol, Rheum palmatum, St. Johns Wort, Stilbenes
Diseases : Cancer Metastasis
Pharmacological Actions : Anti-Angiogenic, Anti-metastatic
[+]

Role of Hypericum perforatum oil and pomegranate seed oil in wound healing: an in vitro study.Aug 31, 2021

Pubmed Data : Z Naturforsch C J Biosci. 2021 Sep 1. Epub 2021 Sep 1. PMID: 34469641
Article Published Date : Aug 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Pomegranate, St. Johns Wort
Diseases : Wound Healing
Additional Keywords : Plant Oils
[+]

St. John's wort (H. perforatum) inhibits HIV-1 viral infection. Jan 01, 2009

Pubmed Data : Virol J. 2009;6:101. Epub 2009 Jul 13. PMID: 19594941
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : HIV Infections
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

St. John's wort and its component hyperforin have promising therapeutic potential for limitation of immune-mediated β-cell dysfunction.Oct 21, 2016

Pubmed Data : Int J Biochem Cell Biol. 2016 Oct 22. Epub 2016 Oct 22. PMID: 27989965
Article Published Date : Oct 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Hyperforin, St. Johns Wort
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Pancreato Protective Agents
Additional Keywords : Gene Expression Regulation
[+]

St. John's Wort contains a novel protein p27SJ which suppresses the HIV-1 virus.Sep 15, 2008

Pubmed Data : Clin Infect Dis. 2008 Sep 15;47(6):804-11. PMID: 18378326
Article Published Date : Sep 15, 2008
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : HIV Infections
[+]

St. John's wort extract induces growth inhibition and programmed cell death in human malignant cells in vitro.Aug 01, 2008

Pubmed Data : J Neurochem. 2008 Aug;106(4):1594-603. Epub 2008 May 31. PMID: 12061257
Article Published Date : Aug 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Cancers: All, Glioblastoma, Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

St. John's Wort has antiviral activity against CytomegalovirusFeb 01, 1991

Pubmed Data : Antiviral Res. 1991 Feb;15(2):101-12. PMID: 1650164
Article Published Date : Feb 01, 1991
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Cytomegalovirus Infections
Pharmacological Actions : Antiviral Agents
[+]

St. John's Wort is as effective as Selective Serotoin Reuptake Inhibitors in the treatment of Depressive Disorder, with a greater safety rating. Feb 01, 2009

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):118-27. Epub 2008 Nov 12. PMID: 19028540
Article Published Date : Feb 01, 2009
Study Type : Review
Additional Links
Substances : St. Johns Wort
Diseases : Depression
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

St. John's wort may be a safe treatment option for women suffering from postpartum depression. Jan 01, 2002

Pubmed Data : Pharmacopsychiatry. 2002 Jan;35(1):29-30. PMID: 11819157
Article Published Date : Jan 01, 2002
Study Type : Commentary
Additional Links
Substances : St. Johns Wort
Diseases : Postnatal Depression
[+]

St. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment.Nov 20, 2018

Pubmed Data : J Cell Physiol. 2018 Nov 21. Epub 2018 Nov 21. PMID: 30461013
Article Published Date : Nov 20, 2018
Study Type : Review
Additional Links
Substances : St. Johns Wort
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

St. John's Wort suppresses HIV-1 virus. Feb 01, 2006

Pubmed Data : Gene Ther. 2006 Feb;13(4):288-95. PMID: 16251997
Article Published Date : Feb 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : HIV Infections
[+]

St. Jonh's wort inhibits ultraviolet light-induced activation of HIV gene expression in HeLa cells. Dec 01, 2002

Pubmed Data : IUBMB Life. 2002 Dec;54(6):357-64. PMID: 12665247
Article Published Date : Dec 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents, NF-kappaB Inhibitor
[+]

The anti-HIV-1 activity of hypercin (St. John's wort) is dependent on activation through visible light. Feb 01, 1993

Pubmed Data : Antiviral Res. 1993 Feb;20(2):173-8. PMID: 8460933
Article Published Date : Feb 01, 1993
Study Type : Commentary
Additional Links
Substances : St. Johns Wort
Diseases : HIV Infections
Therapeutic Actions : Light Therapy
Pharmacological Actions : Antiviral Agents
[+]

The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells.Oct 31, 2018

Pubmed Data : Anticancer Drugs. 2018 Nov ;29(10):983-994. PMID: 30063472
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : St. Johns Wort
Diseases : Cancers: Drug Resistant, Colon Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

This preliminary evaluation demonstrated a synergistic property of O. vulgare and H. perforatum extracts in treating S. aureus infection.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Future Sci OA. 2019 Mar ;5(3):FSO371. Epub 2019 Jan 31. PMID: 30906567
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Oregano, St. Johns Wort
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance Synergy
[+]

This research demonstrated efficacy and safety of Iranian herbal medicines in alleviating PMS.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 Mar-Apr;8(2):96-113. PMID: 29632841
Article Published Date : Feb 28, 2018
Study Type : Review
Additional Links
Substances : Chamomile, Chaste Tree (Chasteberry), Curcumin, Fennel, Flaxseed, Ginger, Lemon Balm, Orange, Saffron, St. Johns Wort, Valerian, Wheat Germ, Zataria multiflora
Diseases : Premenstrual syndrome
Additional Keywords : Traditional Iranian Medicine
[+]

St. John's wort in combination with photodynamic therapy inhibit the growth of human pancreatic cancer cells. Sep 01, 2000

Pubmed Data : J Surg Res. 2000 Sep;93(1):137-43. PMID: 10945955
Article Published Date : Sep 01, 2000
Additional Links
Substances : St. Johns Wort
Diseases : Pancreatic Cancer
[+]

St. John's Wort's cortisol reducing effect in brain may contribute to antidepressive effectJan 01, 2004

Pubmed Data : Eur Neuropsychopharmacol. 2004 Jan;14(1):7-10. PMID:14659982
Article Published Date : Jan 01, 2004
Additional Links
Substances : St. Johns Wort
Diseases : Cortisol: High, Depression

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There are a broad range of evidence-based natural alternatives for depression. GreenMedInfo.com sources its research from the public domain, namely, the National Library of Medicine's bibliographic database known as Medline
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Millions are helplessly addicted to tobacco, unaware that a natural aid for smoking cessation can be found not at the local pharmacy, but at your grocer's fruit stand.
38 Natural Alternatives for HIV
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Fortunately, natural substances are being researched for their therapeutic value for our immune health. "Superbugs" develop due to repeated, frequent and multiple different antibiotic prescriptions. Plant products have historically been consumed and utilized for their anti-microbial and holistic benefits. Here are 38 natural substances which indicate potential benefit for people with HIV.
Natural Solutions for The Double Burden of Depression & Anxiety
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Alarmingly, about 85% of people with depression also experience some anxiety; about 90% of people with anxiety suffer some depression
Magnesium: The Safe First Line of Defense for Clinical Depression
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The science supporting the efficacy of magnesium for major depression and other psychiatric disorders, testing for magnesium deficiency, and which forms and dosages are most effective

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