Stigmasterol

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3 Diseases Researched for Stigmasterol
NameACCKFocus
Epstein-Barr Virus Infections11Locked
Methicillin-resistant Staphylococcus aureus11Locked
Hyperthyroidism10Locked
2 Pharmacological Actions Researched for Stigmasterol
NameACCKFocus
Anti-Bacterial Agents11Locked
Anticarcinogenic Agents11Locked

View the Evidence:
28 Abstracts with Stigmasterol Research

[+]

Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation.Jun 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Jun 27 ;153:113317. Epub 2022 Jun 27. PMID: 35772378
Article Published Date : Jun 26, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Anti-diabetic potential of a stigmasterol from the seaweed Gelidium spinosum.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2021 ;8:694362. Epub 2021 Sep 16. PMID: 34604273
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Hyperglycemia
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
[+]

Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet.Sep 30, 2018

Pubmed Data : Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct ;1863(10):1274-1284. Epub 2018 Aug 7. PMID: 30305244
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol, Stigmasterol
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anticholesteremic Agents, Hepatoprotective
Anti Therapeutic Actions : Western Diet
[+]

Investigation of the anti-inflammatory effects of stigmasterol.Nov 30, 2021

Pubmed Data : Behav Pharmacol. 2021 Dec 1 ;32(8):640-651. PMID: 34657071
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Lupeol and stigmasterol suppress tumor angiogenesis and inhibit cholangiocarcinoma growth.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(12):e0189628. Epub 2017 Dec 12. PMID: 29232409
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lupeol, Stigmasterol
Diseases : Cholangiocarcinoma
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Stigmasterol and β-sitosterol has beneficial effects on non-alcoholic fatty liver disease.Apr 03, 2018

Pubmed Data : J Agric Food Chem. 2018 Apr 4 ;66(13):3417-3425. Epub 2018 Mar 27. PMID: 29583004
Article Published Date : Apr 03, 2018
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol, Stigmasterol
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Stigmasterol attenuates hepatic steatosis in rats by strengthening the intestinal barrier and improving bile acid metabolism.Aug 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : NPJ Sci Food. 2022 Aug 27 ;6(1):38. Epub 2022 Aug 27. PMID: 36030278
Article Published Date : Aug 26, 2022
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Hepatic Steatosis
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective, Hepatoprotective
[+]

Stigmasterol can be new steroidal treatment for neurological disorders.Jun 29, 2021

Pubmed Data : Phytomedicine. 2021 Jun 30 ;90:153646. Epub 2021 Jun 30. PMID: 34280827
Article Published Date : Jun 29, 2021
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Anxiety, Epilepsy
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants, GABA Modulators
[+]

Stigmasterol could stop the proliferation and the major pathological features of T. congolense infection.Apr 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 May ;89:482-489. Epub 2017 Feb 27. PMID: 28249250
Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Parasitic Diseases
Pharmacological Actions : Antiparasitic Agents
[+]

Stigmasterol demonstrates significant potential as a molecule of interest in allergic skin disease therapy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2018 ;2018:3984068. Epub 2018 Jul 24. PMID: 30140696
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Angioedema, Atopic Dermatitis, Psoriasis, Skin Diseases: Inflammatory, Urticaria
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Stigmasterol inhibits lipopolysaccharide-induced innate immune responses in murine models.Nov 30, 2017

Pubmed Data : Int Immunopharmacol. 2017 Dec ;53:105-113. PMID: 29078089
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Immunomodulatory
[+]

Stigmasterol possessed significant antiasthmatic properties and had suppressive effects on key features of allergen-induced asthma.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2017 ;2017:2953930. Epub 2017 May 5. PMID: 28555089
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Asthma, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Stigmasterol restores the balance of Treg/Th17 cells by activating the butyrate-PPARγ axis in colitis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2021 ;12:741934. Epub 2021 Oct 6. PMID: 34691046
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2017 ;61(1):1364117. Epub 2017 Aug 23. PMID: 28970778
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Diabetes Mellitus: Type 2
[+]

The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor.Jan 19, 2022

Pubmed Data : BMC Pharmacol Toxicol. 2022 06 20 ;23(1):42. Epub 2022 Jun 20. PMID: 35725497
Article Published Date : Jan 19, 2022
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
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These findings reveal that stigmasterol has neuro-protective effect against the ischemic/reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychiatr Dis Treat. 2019 ;15:2991-3001. Epub 2019 Oct 18. PMID: 31695390
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Autophagy Inhibitors, Neuroprotective Agents
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These results suggest that dietary intake of stigmasterol and β-sitosterol ameliorates colitis.Nov 14, 2017

Pubmed Data : Food Funct. 2017 Nov 15 ;8(11):4179-4186. PMID: 29034917
Article Published Date : Nov 14, 2017
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol, Stigmasterol
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
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These results support the potential anti-nociceptive effect of stigmasterol in different models of pain.Oct 31, 2017

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2017 Nov ;390(11):1163-1172. Epub 2017 Aug 18. PMID: 28821921
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
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Coleus tuberosus extract and its phytosterols inhibit Epstein-Barr associated tumor-promoting activity.May 01, 2010

Pubmed Data : Chem Biodivers. 2010 May;7(5):1267-75. PMID: 20491082
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Beta Sitosterol, Campesterol , Coleus tuberosus, Phytosterols, Stigmasterol
Diseases : Epstein-Barr Virus Infections
Pharmacological Actions : Anticarcinogenic Agents
[+]

In vitro antileishmanial effects of saffron compounds, crocin and stigmasterol, on Iranian strain of Leishmania major.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Parasitol. 2021 Jan-Mar;16(1):151-158. PMID: 33786057
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Saffron, Stigmasterol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2021 Dec ;12(2):9332-9340. PMID: 34806937
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation
[+]

Stigmasterol as the one of the main compounds of XYS suppresses ovarian cancer cell activities through the PI3K-Akt signaling pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dis Markers. 2021 ;2021:4304507. Epub 2021 Jun 29. PMID: 34306252
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative
[+]

Stigmasterol inhibits the progression of lung cancer by regulating retinoic acid-related orphan receptor C.Oct 28, 2021

Pubmed Data : Histol Histopathol. 2021 Oct 29:18388. Epub 2021 Oct 29. PMID: 34713889
Article Published Date : Oct 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Stigmasterol promotes neuronal migration via reelin signaling in neurosphere migration assays.Nov 14, 2018

Pubmed Data : Nutr Neurosci. 2018 Nov 15:1-9. Epub 2018 Nov 15. PMID: 30433855
Article Published Date : Nov 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Central Nervous System Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2020 ;20:480. Epub 2020 Oct 6. PMID: 33041661
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Endometrial Cancer
Pharmacological Actions : Chemosensitizer
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Stigmasterol simultaneously induces apoptosis and protective autophagy by inhibiting Akt/mTOR pathway in gastric cancer cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2021 ;11:629008. Epub 2021 Feb 23. PMID: 33708631
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Stigmasterol
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
[+]

This study highlights the potential of both stigmasterol and lupeol as new promising anti-MRSA agents.Dec 08, 2016

Pubmed Data : J Glob Antimicrob Resist. 2016 Dec 9 ;8:48-54. Epub 2016 Dec 9. PMID: 27992774
Article Published Date : Dec 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lupeol, Stigmasterol
Diseases : Methicillin-resistant Staphylococcus aureus
Pharmacological Actions : Anti-Bacterial Agents
[+]

Stigmasterol isolated from Butea monosperma has thyroid inhibitory activity. Nov 10, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Nov 10. Epub 2009 Nov 10. PMID: 19105977
Article Published Date : Nov 10, 2009
Additional Links
Substances : Stigmasterol
Diseases : Hyperthyroidism

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