Sulforaphane

Name	AC	CK
Oxidative Stress	44	106
Inflammation	22	49
Prostate Cancer	27	42
Breast Cancer	28	36
Colon Cancer	17	35
Autism Spectrum Disorders	6	33
Breast Cancer: Triple Negative	8	29
Cancers: All	20	29
Pancreatic Cancer	17	28
Diabetes Mellitus: Type 2	10	27
DNA damage	7	26
Bladder Cancer	12	24
Insulin Resistance	6	23
Air Pollution Linked Toxicity	3	21
Liver Cancer	14	20
Lung Cancer	13	18
Helicobacter Pylori Infection	5	17
Melanoma	6	17
Lipopolysaccharide-Induced Toxicity	12	16
Prostate Cancer: Prevention	4	14
Alzheimer's Disease	6	13
Asthma	2	12
Autism	2	12
Chemotherapy-Induced Toxicity: Cisplatin	5	12
Colorectal Cancer	6	12
Diesel Exhaust Particle Toxicity	3	12
Fatty Liver	2	12
Glutathione Deficiency	3	12
Cancer Metastasis	9	11
Obesity	6	11
Ovarian Cancer	7	11
Schizophrenia	2	11
Skin Diseases	2	11
Anemia: Sickle Cell	1	10
Benzene Toxicity	1	10
Bladder Degeneration	1	10
COPD	1	10
Cancers: Drug Resistant	5	10
Cognitive Decline/Dysfunction	5	10
Cystic Fibrosis	1	10
Gastritis	1	10
Hyperinsulinism	1	10
Lung Diseases	1	10
Prostate: PSA Doubling	1	10
Psychiatric Disorders	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Cadmium Poisoning	4	9
Gastric Cancer	4	9
Leukemia	5	9
Endothelial Dysfunction	3	8
Aging	2	7
Cancers	3	7
Cardiovascular Diseases	6	7
Cerebral Ischemia	4	7
Chemotherapy-Induced Toxicity: Doxorubicin	6	7
Hypoxia	5	7
Ischemia	4	7
Neurodegenerative Diseases	5	7
Adenomatous Polyposis Coli	3	6
Chemically-Induced Liver Damage	4	6
Skin Cancer: Prevention	3	6
Brain Damage	3	5
Breast Cancer: Estrogen	1	5
Cancer Stem Cells	5	5
Carcinoma: Non-Small-Cell Lung	4	5
Colorectal Cancer: Prevention	1	5
Endothelial Damage	1	5
Female	1	5
Fetal Alcoholism	1	5
Gastric Cancer: Prevention	1	5
Glioblastoma	4	5
Immune Disorders: Low Immune Function	3	5
Insulin Disorders	1	5
Lipid Peroxidation	1	5
Skin Cancer	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Aflatoxicosis	3	4
Aspirin-Induced Toxicity	2	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Cardiomyopathy	2	4
Depression	2	4
Diabetes Mellitus: Type 1	2	4
Diabetic Complications	2	4
Head and Neck Cancer	4	4
Hydrogen Peroxide Induced Toxicity	4	4
Intestinal Polyps	2	4
Muscle Damage: Exercise-Induced	2	4
NSAID-induced toxicity	2	4
Nasopharyngeal Cancer	3	4
Nicotine/Tobacco Toxicity	2	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Parkinson's Disease	4	4
Spinal Cord Injuries	2	4
Stroke	2	4
Traumatic Brain Injury	2	4
Advanced Glycation End products (AGE)	2	3
Aging Skin	2	3
Benzo[a]pyrene-induced Toxicity	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Brain Inflammation	2	3
Cervical Cancer	3	3
Chemotherapy-Induced Toxicity	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Diabetic Nephropathy	2	3
Drug-Induced Toxicity: Indomethacin	2	3
Gastric Ulcer	2	3
Intestinal Diseases	2	3
Liver Damage	2	3
Liver Damage: Aflatoxin-Induced	2	3
Low Disorders: Low TH1	2	3
Melanoma: Metastatic	2	3
Multiple Myeloma	2	3
Multiple Sclerosis	2	3
Myocardial Ischemia	2	3
Oral Cancer	2	3
Osteosarcoma	2	3
Petroleum Exposure And Toxicity	2	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Rheumatoid Arthritis	2	3
Skin Diseases: Photo-Aging	2	3
Aging: Heart	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Amphetamine Addiction/Withdrawal	1	2
Anxiety Disorders	1	2
Atherosclerosis	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Bacterial Infections and Mycoses	2	2
Bladder Dysfunction	1	2
Bladder Outlet Obstruction	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Breast Cancer: Metastatic	2	2
C-Reactive Protein	1	2
Cancers: Multi-Drug Resistant	1	2
Carbon Monoxide Poisoning	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Chronic Pain	1	2
Coronavirus Infection	1	2
Depressive Disorder	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Memory Problems	1	2
Duchenne's Muscular Dystrophy	1	2
Dyslipidemias	1	2
Endometriosis	1	2
Epstein-Barr Virus Infections	1	2
Escherichia coli Infections	1	2
Gastrointestinal Cancer	1	2
Glioma	2	2
Gout	1	2
Heart Failure	1	2
Heavy Metal Toxicity	1	2
High Fat Diet	1	2
Hypertension	1	2
Hypoglycemia	2	2
Hypogonadism	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Infertility: Male	1	2
Intoxication	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Light Sensitivity	1	2
Liver Disease	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Memory Disorders	1	2
Mercury Poisoning	1	2
Mitochondrial Dysfunction	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
Musculoskeletal Diseases	1	2
Myocardial Infarction	1	2
Nephropathy	1	2
Neurologic Disorders	1	2
Neuropathic Pain	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation	1	2
Promyelocytic leukemia	2	2
Pulmonary Hypertension	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Schwannoma: Vestibular	1	2
Seizures	1	2
Serotonin Disorders	1	2
Sickle Cell Anemia	1	2
Smoking	1	2
Stroke: Recovery	1	2
Testicular Injury: Cadmium-Induced	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tumors	2	2
Ulcerative Colitis	1	2
Ultraviolet Radiation Induced Damage	2	2
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Arsenic Poisoning	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Injury: Hippocampal Damage	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Prevention	1	1
Cardiac Hypertrophy	1	1
Cardiovascular Disease: Prevention	1	1
Cholesterol: LDL/HDL ratio	1	1
Chronic Kidney Disease (CKD)	1	1
Colon Cancer: Prevention	1	1
Colorectal Tumors	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Dystrophic retinal detachment (DRD)	1	1
Encephalomyelitis	1	1
Excitotoxicity	1	1
Fibrosis	1	1
Fungal Infection	1	1
Gastrointestinal Diseases	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HDL: Low	1	1
HIV Infections	1	1
Hepatitis C	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
Hyperglycemia	1	1
IgE-Mediated Hypersensitivity	1	1
Keloid	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Liver Cancer: Prevention	1	1
Liver Failure: Acute	1	1
Liver Fibrosis	1	1
Lung Cancer: Prevention	1	1
Lymphoma	1	1
Macular Degeneration	1	1
Malignant Melanoma	1	1
Medulloblastoma	1	1
Melanism	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Muscle Atrophy	1	1
Neurological Conditions	1	1
Oral Cancer: Prevention	1	1
Osteoarthritis	1	1
Osteoporosis	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Pesticide Toxicity	1	1
Prediabetes	1	1
Restenosis	1	1
Retinal Diseases	1	1
Schizophrenic Disorders	1	1
Squamous cell carcinoma	1	1
Stomach Cancer	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1

Name	AC	CK
Antioxidants	93	207
Apoptotic	95	157
Anticarcinogenic Agents	87	150
Anti-Inflammatory Agents	59	136
Nrf2 activation	69	132
Antiproliferative	68	126
Chemopreventive	61	110
Neuroprotective Agents	42	91
Phase II Detoxification Enzyme Inducer	17	44
Cell cycle arrest	31	39
Antioxidant Effects	14	38
NF-kappaB Inhibitor	25	34
Tumor Necrosis Factor (TNF) Alpha Inhibitor	20	32
Chemotherapeutic	23	31
Hepatoprotective	13	29
Anti-metastatic	18	25
Interleukin-1 beta downregulation	15	25
Interleukin-6 Downregulation	17	25
Histone deacetylase inhibitor	14	24
Cyclooxygenase 2 Inhibitors	15	23
Glutathione Upregulation	4	22
Cytoprotective	5	21
Antineoplastic Agents	12	20
Chemosensitizer	17	20
Enzyme Inhibitors	7	16
MicroRNA modulator	15	16
Cardioprotective	12	15
NF-E2-Related Factor-2 (Nrf2) Modulator	10	15
Anti-Apoptotic	6	14
Antioxidant	4	13
Anti-Angiogenic	6	12
Detoxifier	3	12
Genoprotective	2	11
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	11
Anti-Allergic Agents	1	10
Heme oxygenase-1 up-regulation	8	10
Insulin Down-Regulation	1	10
Immunomodulatory	6	9
Insulin Sensitizers	3	9
Superoxide Dismutase Up-regulation	3	9
Tumor Suppressor Protein p53 Upregulation	5	9
Glucose Uptake Optimization	3	8
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	8
Anti-Tumor	2	7
Autophagy Up-regulation	3	7
Renoprotective	5	7
Anti Inflammatory	4	6
Anti-Proliferative	2	6
Chemoprotective Agents	5	6
Wnt/β-catenin pathway down-regulation	2	6
Anti-cancer	1	5
Gastrointestinal Agents	3	5
HER-2 oncoprotein down-regulation	1	5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	5
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	5
Immune Enhancing Properties	1	5
NADPH Oxidase Inhibitors	1	5
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation	1	5
Regenerative	1	5
Antidepressive Agents	2	4
Antiviral Agents	3	4
Bcl-2 protein down-regulation	4	4
Immunomodulatory: Th17 downregulation	2	4
Malondialdehyde Down-regulation	2	4
Nitric Oxide Inhibitor	2	4
Vascular Endothelial Growth Factor Inhibitors	2	4
Anti-Bacterial Agents	3	3
Anti-Fibrotic	3	3
Anti-Ulcer Agents	2	3
Hypoglycemic Agents	2	3
Interferon Gamma Reducer	2	3
Interleukin-10 upregulation	2	3
Radioprotective	2	3
Telomerase Inhibitor	3	3
Wnt/β-catenin signaling pathway modulation	3	3
Angiogenesis Inhibitors	1	2
Anti-Anxiety Agents	1	2
Anticonvulsants	1	2
Antimicrobial	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Brain-derived neurotrophic factor modulator	1	2
Cytotoxic	2	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Gastroprotective	1	2
Heat Shock Protein Inducer	1	2
Hypolipidemic	1	2
Hypotensive	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 upregulation	1	2
Interleukin-23 Downregulation	1	2
Leptin Down-Regulation	1	2
Lipolytic	1	2
Malonaldehyde (MDA) Down-Regulation	1	2
Metallothionein Up-regulation	1	2
Neurogenesis	1	2
PI3K-AKT inhibitor	1	2
Peroxisome Proliferators	1	2
Phase I Detoxification Enzyme Inducer	1	2
Platelet aggregation inhibitor: collagen-induced aggregation	1	2
Prostaglandin PGE2 downregulation	1	2
Proteasome Inhibitors	2	2
Serotonergic	1	2
Anti-Glycation Agents	1	1
Antifungal Agents	1	1
Antimitotic Agents	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
Estrogen Receptor Modulators	1	1
Interleukin-4 upregulation	1	1
Interleukin-8 downregulation	1	1
Osteoprotective	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Radiosensitizer	1	1
Survivin Down-Regulation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1

[+]

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

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Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973

Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise.Jan 11, 2021

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Pubmed Data : Physiol Rep. 2021 12 ;9(24):e15130. PMID: 34927380

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Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126

Article Published Date : Jul 03, 2019

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Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539

Article Published Date : Apr 29, 2015

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Schizophrenia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

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Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID: 30595796

Article Published Date : Jan 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Nrf2 activation

Additional Keywords : calorie restriction, High Sugar Diet, Isothiocyanates

[+]

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

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Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615

Article Published Date : Oct 31, 2012

Study Type : Animal Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Bladder Cancer

Pharmacological Actions : Chemopreventive

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Pubmed Data : Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID: 29797311

Article Published Date : Jan 01, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Stroke

Pharmacological Actions : Platelet aggregation inhibitor: collagen-induced aggregation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables

[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

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Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

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Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925

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Pubmed Data : Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID: 26025579

Article Published Date : May 25, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation

[+]

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

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Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558

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Pubmed Data : J Neurosurg. 2017 Jan 6:1-12. Epub 2017 Jan 6. PMID: 28059653

Article Published Date : Jan 05, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Antiproliferative, Apoptotic, Cancer Stem Cells, glioblastoma (GBM), Sulforaphane

[+]

Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS.Jul 02, 2020

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Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose.Mar 17, 2020

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Pubmed Data : Neurochem Int. 2020 Mar 18:104728. Epub 2020 Mar 18. PMID: 32199985

Article Published Date : Mar 17, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Sulforaphane attenuates chronic intermittent hypoxia-induced brain damage.Dec 31, 2021

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Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666

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Pubmed Data : Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151

Article Published Date : Aug 01, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Malonaldehyde (MDA) Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

[+]

Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.Feb 01, 2019

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Pubmed Data : Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379

Article Published Date : Feb 01, 2019

Study Type : Animal Study

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Pubmed Data : Mol Nutr Food Res. 2019 02 ;63(4):e1800795. Epub 2019 Jan 11. PMID: 30578708

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Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

Problem Substances : Insulin

[+]

Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

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Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis. May 01, 2011

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Pubmed Data : Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID: 21278056

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Pubmed Data : Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID: 16675473

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Adenomatous Polyposis Coli, Colorectal Cancer, Intestinal Polyps

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive

[+]

Sulforaphane prevents cell death and inflammation in nephropathy.Jun 16, 2011

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Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138

Article Published Date : Jun 16, 2011

[+]

Sulforaphane protects against cisplatin-induced liver and mitochondrial damage. Aug 15, 2011

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Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670

Article Published Date : Aug 15, 2011

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Pubmed Data : Diabetes Metab J. 2021 Jun 4. Epub 2021 Jun 4. PMID: 34082508

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[+]

Additional Keywords : Antioxidant, Autoimmune Diseases, Cruciferous Vegetables, Multiple Sclerosis, Phytotherapy, Sulforaphane

[+]

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts has profound anti-Helicobacter pylori activity in human gastric xenografts implanted in nude mice. Dec 01, 2003

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Pubmed Data : Antimicrob Agents Chemother. 2003 Dec;47(12):3982-4. PMID: 14638516

Article Published Date : Dec 01, 2003

Study Type : Transgenic Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Helicobacter Pylori Infection

Additional Keywords : Plant Extracts

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Plant Foods Hum Nutr. 2018 Jun ;73(2):95-100. PMID: 29675806

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Broccoli Sprouts, Isothiocyanates, Sulforaphane

Diseases : Colon Cancer, Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive

[+]

MicroRNAs as novel targets of sulforaphane in cancer therapy.Jan 22, 2020

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Pubmed Data : Phytother Res. 2020 Jan 23. Epub 2020 Jan 23. PMID: 31972874

Article Published Date : Jan 22, 2020

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Cancers: All

Pharmacological Actions : Chemotherapeutic, MicroRNA modulator

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Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise.Jan 11, 2021

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder.Apr 28, 2020

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.May 01, 2018

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.Jan 01, 2018

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.Jan 15, 2018

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.Jan 01, 2018

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.Dec 01, 2018

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.May 25, 2015

Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.Jul 08, 2019

Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.Aug 01, 2018

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.Mar 11, 2018

Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro. Aug 01, 2019

Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.Jun 04, 2018

Sulforphane exhibits immunomodulatory properties on human placenta cells in vitro.Feb 01, 2019

The addition of broccoli and watercress in the diet may reduce risk of breast cancerDec 01, 2005

The protective effect of sulforaphane against oxidative stress.Oct 31, 2021

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."May 28, 2012

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."Dec 31, 2011

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."Jun 30, 2012

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."Sep 01, 2011

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."Aug 22, 2012

Age-related mitochondrial impairment and renal injury is ameliorated by sulforaphane.Jan 13, 2022

Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice.Oct 31, 2020

Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.Jan 01, 2018

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity. Mar 01, 2009

Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.Oct 10, 2016

Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.Jun 06, 2018

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.Oct 01, 2009

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation. Oct 30, 2007

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue. Jul 01, 2007

Brussel sprouts induce detoxifying enzymes. Aug 01, 2010

Co-administration of SFN reversed the DOX-associated reduction in nuclear Nrf2 binding activity and restored cardiac expression of Nrf2-regulated genes, at both the RNA and protein levels.May 25, 2015

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Consumption of sulforaphane-enriched broccoli soup may inhibit bacterial growth in the stomach and upper small intestine.Jul 09, 2020

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503 Abstracts with Sulforaphane Research