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Sulforaphane
Views 20750
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260 Diseases Researched for Sulforaphane
Name
AC
CK
Focus
Oxidative Stress
44
106
Inflammation
22
49
Prostate Cancer
27
42
Breast Cancer
28
36
Colon Cancer
17
35
Autism Spectrum Disorders
6
33
Breast Cancer: Triple Negative
8
29
Cancers: All
20
29
Pancreatic Cancer
17
28
Diabetes Mellitus: Type 2
10
27
DNA damage
7
26
Bladder Cancer
12
24
Insulin Resistance
6
23
Air Pollution Linked Toxicity
3
21
Liver Cancer
14
20
Lung Cancer
13
18
Helicobacter Pylori Infection
5
17
Melanoma
6
17
Lipopolysaccharide-Induced Toxicity
12
16
Prostate Cancer: Prevention
4
14
Alzheimer's Disease
6
13
Asthma
2
12
Autism
2
12
Chemotherapy-Induced Toxicity: Cisplatin
5
12
Colorectal Cancer
6
12
Diesel Exhaust Particle Toxicity
3
12
Fatty Liver
2
12
Glutathione Deficiency
3
12
Cancer Metastasis
9
11
Obesity
6
11
Ovarian Cancer
7
11
Schizophrenia
2
11
Skin Diseases
2
11
Anemia: Sickle Cell
1
10
Benzene Toxicity
1
10
Bladder Degeneration
1
10
COPD
1
10
Cancers: Drug Resistant
5
10
Cognitive Decline/Dysfunction
5
10
Cystic Fibrosis
1
10
Gastritis
1
10
Hyperinsulinism
1
10
Lung Diseases
1
10
Prostate: PSA Doubling
1
10
Psychiatric Disorders
1
10
Pulmonary Fibrosis
1
10
Radical Prostatectomy
1
10
Respiratory Diseases
1
10
Cadmium Poisoning
4
9
Gastric Cancer
4
9
Leukemia
5
9
Endothelial Dysfunction
3
8
Aging
2
7
Cancers
3
7
Cardiovascular Diseases
6
7
Cerebral Ischemia
4
7
Chemotherapy-Induced Toxicity: Doxorubicin
6
7
Hypoxia
5
7
Ischemia
4
7
Neurodegenerative Diseases
5
7
Adenomatous Polyposis Coli
3
6
Chemically-Induced Liver Damage
4
6
Skin Cancer: Prevention
3
6
Brain Damage
3
5
Breast Cancer: Estrogen
1
5
Cancer Stem Cells
5
5
Carcinoma: Non-Small-Cell Lung
4
5
Colorectal Cancer: Prevention
1
5
Endothelial Damage
1
5
Female
1
5
Fetal Alcoholism
1
5
Gastric Cancer: Prevention
1
5
Glioblastoma
4
5
Immune Disorders: Low Immune Function
3
5
Insulin Disorders
1
5
Lipid Peroxidation
1
5
Skin Cancer
4
5
Acetaminophen (Tylenol) Toxicity
2
4
Aflatoxicosis
3
4
Aspirin-Induced Toxicity
2
4
Brain Injury: Traumatic
2
4
Brain: Microglial Activation
2
4
Cardiomyopathy
2
4
Depression
2
4
Diabetes Mellitus: Type 1
2
4
Diabetic Complications
2
4
Head and Neck Cancer
4
4
Hydrogen Peroxide Induced Toxicity
4
4
Intestinal Polyps
2
4
Muscle Damage: Exercise-Induced
2
4
NSAID-induced toxicity
2
4
Nasopharyngeal Cancer
3
4
Nicotine/Tobacco Toxicity
2
4
Organ Transplantation: Pancreatic Islet Cells
2
4
Parkinson's Disease
4
4
Spinal Cord Injuries
2
4
Stroke
2
4
Traumatic Brain Injury
2
4
Advanced Glycation End products (AGE)
2
3
Aging Skin
2
3
Benzo[a]pyrene-induced Toxicity
2
3
Blood-Brain-Barrier Disorders
2
3
Brain Cancer
3
3
Brain Inflammation
2
3
Cervical Cancer
3
3
Chemotherapy-Induced Toxicity
2
3
Diabetes Mellitus: Type 1: Prevention
2
3
Diabetic Nephropathy
2
3
Drug-Induced Toxicity: Indomethacin
2
3
Gastric Ulcer
2
3
Intestinal Diseases
2
3
Liver Damage
2
3
Liver Damage: Aflatoxin-Induced
2
3
Low Disorders: Low TH1
2
3
Melanoma: Metastatic
2
3
Multiple Myeloma
2
3
Multiple Sclerosis
2
3
Myocardial Ischemia
2
3
Oral Cancer
2
3
Osteosarcoma
2
3
Petroleum Exposure And Toxicity
2
3
Polycyclic aromatic hydrocarbon (PAH) toxicity
2
3
Rheumatoid Arthritis
2
3
Skin Diseases: Photo-Aging
2
3
Aging: Heart
1
2
Alcohol Toxicity
1
2
Alcoholic Liver Disease
1
2
Amphetamine Addiction/Withdrawal
1
2
Anxiety Disorders
1
2
Atherosclerosis
1
2
Atopic Dermatitis
1
2
Autoimmune Diseases
1
2
Bacterial Infections and Mycoses
2
2
Bladder Dysfunction
1
2
Bladder Outlet Obstruction
1
2
Brain Edema
1
2
Brain Hypoxia
2
2
Breast Cancer: Metastatic
2
2
C-Reactive Protein
1
2
Cancers: Multi-Drug Resistant
1
2
Carbon Monoxide Poisoning
1
2
Chemical Exposure
1
2
Chemical Weapon Agent Injury
1
2
Chronic Pain
1
2
Coronavirus Infection
1
2
Depressive Disorder
1
2
Diabetes: Cognitive Dysfunction
1
2
Diabetes: Memory Problems
1
2
Duchenne's Muscular Dystrophy
1
2
Dyslipidemias
1
2
Endometriosis
1
2
Epstein-Barr Virus Infections
1
2
Escherichia coli Infections
1
2
Gastrointestinal Cancer
1
2
Glioma
2
2
Gout
1
2
Heart Failure
1
2
Heavy Metal Toxicity
1
2
High Fat Diet
1
2
Hypertension
1
2
Hypoglycemia
2
2
Hypogonadism
1
2
Immune Dysregulation: TH1/TH2 imbalance
1
2
Infertility: Male
1
2
Intoxication
1
2
Kidney Diseases
1
2
Lead Poisoning
1
2
Light Sensitivity
1
2
Liver Disease
1
2
Low Immune Function: Natural Killer Cells
1
2
Malathion Toxicity
1
2
Memory Disorders
1
2
Mercury Poisoning
1
2
Mitochondrial Dysfunction
1
2
Muscle Fatigue
1
2
Muscle Soreness
1
2
Musculoskeletal Diseases
1
2
Myocardial Infarction
1
2
Nephropathy
1
2
Neurologic Disorders
1
2
Neuropathic Pain
1
2
Nonalcoholic fatty liver disease (NAFLD)
1
2
Organ Transplantation
1
2
Promyelocytic leukemia
2
2
Pulmonary Hypertension
1
2
Respiratory Syncytial Virus Infections
1
2
Respiratory Tract Infections
1
2
Salivary Gland Adenoid Cystic Carcinoma.
2
2
Salivary Gland Diseases
2
2
Schwannoma: Vestibular
1
2
Seizures
1
2
Serotonin Disorders
1
2
Sickle Cell Anemia
1
2
Smoking
1
2
Stroke: Recovery
1
2
Testicular Injury: Cadmium-Induced
1
2
Testicular Injury: Chemical/Metal Induced
1
2
Tumors
2
2
Ulcerative Colitis
1
2
Ultraviolet Radiation Induced Damage
2
2
Allergies
1
1
Androgen-Induced Diseases
1
1
Aortic Plaques
1
1
Arsenic Poisoning
1
1
Bone Destructive Diseases: Over-Active Osteoclasts
1
1
Brain Injury: Hippocampal Damage
1
1
Breast Cancer: HER-2 Overexpressed
1
1
Breast Cancer: Prevention
1
1
Cardiac Hypertrophy
1
1
Cardiovascular Disease: Prevention
1
1
Cholesterol: LDL/HDL ratio
1
1
Chronic Kidney Disease (CKD)
1
1
Colon Cancer: Prevention
1
1
Colorectal Tumors
1
1
Dopamine Deficiency
1
1
Drug-Induced Toxicity
1
1
Dystrophic retinal detachment (DRD)
1
1
Encephalomyelitis
1
1
Excitotoxicity
1
1
Fibrosis
1
1
Fungal Infection
1
1
Gastrointestinal Diseases
1
1
Gram-Negative Bacterial Infections
1
1
Gram-Positive Bacterial Infections
1
1
HDL: Low
1
1
HIV Infections
1
1
Hepatitis C
1
1
Heterocyclic Aromatic Amine Induced Toxicity
1
1
Hyperglycemia
1
1
IgE-Mediated Hypersensitivity
1
1
Keloid
1
1
Kidney Damage
1
1
Leukemia: Acute promyelocytic leukemia
1
1
Liver Cancer: Prevention
1
1
Liver Failure: Acute
1
1
Liver Fibrosis
1
1
Lung Cancer: Prevention
1
1
Lymphoma
1
1
Macular Degeneration
1
1
Malignant Melanoma
1
1
Medulloblastoma
1
1
Melanism
1
1
Microcystis aeruginosa
1
1
Mitochondrial Diseases
1
1
Muscle Atrophy
1
1
Neurological Conditions
1
1
Oral Cancer: Prevention
1
1
Osteoarthritis
1
1
Osteoporosis
1
1
Osteoporosis: Over-active Osteoclasts
1
1
Pancreatic Cancer Stem Cell
1
1
Pesticide Toxicity
1
1
Prediabetes
1
1
Restenosis
1
1
Retinal Diseases
1
1
Schizophrenic Disorders
1
1
Squamous cell carcinoma
1
1
Stomach Cancer
1
1
Striatonigral Degeneration: Autosomal Dominant
1
1
Sunburn
1
1
124 Pharmacological Actions Researched for Sulforaphane
Name
AC
CK
Focus
Antioxidants
93
207
Apoptotic
95
157
Anticarcinogenic Agents
87
150
Anti-Inflammatory Agents
59
136
Nrf2 activation
69
132
Antiproliferative
68
126
Chemopreventive
61
110
Neuroprotective Agents
42
91
Phase II Detoxification Enzyme Inducer
17
44
Cell cycle arrest
31
39
Antioxidant Effects
14
38
NF-kappaB Inhibitor
25
34
Tumor Necrosis Factor (TNF) Alpha Inhibitor
20
32
Chemotherapeutic
23
31
Hepatoprotective
13
29
Anti-metastatic
18
25
Interleukin-1 beta downregulation
15
25
Interleukin-6 Downregulation
17
25
Histone deacetylase inhibitor
14
24
Cyclooxygenase 2 Inhibitors
15
23
Glutathione Upregulation
4
22
Cytoprotective
5
21
Antineoplastic Agents
12
20
Chemosensitizer
17
20
Enzyme Inhibitors
7
16
MicroRNA modulator
15
16
Cardioprotective
12
15
NF-E2-Related Factor-2 (Nrf2) Modulator
10
15
Anti-Apoptotic
6
14
Antioxidant
4
13
Anti-Angiogenic
6
12
Detoxifier
3
12
Genoprotective
2
11
Matrix metalloproteinase-2 (MMP-2) inhibitor
6
11
Anti-Allergic Agents
1
10
Heme oxygenase-1 up-regulation
8
10
Insulin Down-Regulation
1
10
Immunomodulatory
6
9
Insulin Sensitizers
3
9
Superoxide Dismutase Up-regulation
3
9
Tumor Suppressor Protein p53 Upregulation
5
9
Glucose Uptake Optimization
3
8
Matrix metalloproteinase-9 (MMP-9) inhibitor
6
8
Anti-Tumor
2
7
Autophagy Up-regulation
3
7
Renoprotective
5
7
Anti Inflammatory
4
6
Anti-Proliferative
2
6
Chemoprotective Agents
5
6
Wnt/β-catenin pathway down-regulation
2
6
Anti-cancer
1
5
Gastrointestinal Agents
3
5
HER-2 oncoprotein down-regulation
1
5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
4
5
Hypoxia-inducible factor-1 (HIF-1) inhibitor
1
5
Immune Enhancing Properties
1
5
NADPH Oxidase Inhibitors
1
5
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
1
5
Regenerative
1
5
Antidepressive Agents
2
4
Antiviral Agents
3
4
Bcl-2 protein down-regulation
4
4
Immunomodulatory: Th17 downregulation
2
4
Malondialdehyde Down-regulation
2
4
Nitric Oxide Inhibitor
2
4
Vascular Endothelial Growth Factor Inhibitors
2
4
Anti-Bacterial Agents
3
3
Anti-Fibrotic
3
3
Anti-Ulcer Agents
2
3
Hypoglycemic Agents
2
3
Interferon Gamma Reducer
2
3
Interleukin-10 upregulation
2
3
Radioprotective
2
3
Telomerase Inhibitor
3
3
Wnt/β-catenin signaling pathway modulation
3
3
Angiogenesis Inhibitors
1
2
Anti-Anxiety Agents
1
2
Anticonvulsants
1
2
Antimicrobial
1
2
Antinoceceptive
1
2
Autophagy Inhibitors
1
2
Brain-derived neurotrophic factor modulator
1
2
Cytotoxic
2
2
Epidermal growth factor receptor (EGFR) inhibitor
1
2
Fertility Agents: Male
1
2
Gastroprotective
1
2
Heat Shock Protein Inducer
1
2
Hypolipidemic
1
2
Hypotensive
1
2
Interleukin-10 downregulation
1
2
Interleukin-17 downregulation
1
2
Interleukin-18 down-regulation
1
2
Interleukin-2 upregulation
1
2
Interleukin-23 Downregulation
1
2
Leptin Down-Regulation
1
2
Lipolytic
1
2
Malonaldehyde (MDA) Down-Regulation
1
2
Metallothionein Up-regulation
1
2
Neurogenesis
1
2
PI3K-AKT inhibitor
1
2
Peroxisome Proliferators
1
2
Phase I Detoxification Enzyme Inducer
1
2
Platelet aggregation inhibitor: collagen-induced aggregation
1
2
Prostaglandin PGE2 downregulation
1
2
Proteasome Inhibitors
2
2
Serotonergic
1
2
Anti-Glycation Agents
1
1
Antifungal Agents
1
1
Antimitotic Agents
1
1
Beta-Defensin-2 Up-Regulation
1
1
Caspase-3 Activation
1
1
Cell Differentiation Inducer
1
1
Estrogen Receptor Modulators
1
1
Interleukin-4 upregulation
1
1
Interleukin-8 downregulation
1
1
Osteoprotective
1
1
P21 Activation
1
1
Postaglandin PGE2 downregulation
1
1
Quinone Reductase-Inducer
1
1
Radiopharmaceuticals
1
1
Radiosensitizer
1
1
Survivin Down-Regulation
1
1
Vascular Cell Adhesion Molecule-1 Inhibitor
1
1
Vascular Endothelial Growth Factor Regulator
1
1
Research Articles
452
Cumulative Knowledge Score
731
Overall Research Rating
EXCELLENT
Related Topics
Sulforaphane is a Sub of the following Topics
Broccoli
Cruciferous Vegetables
Sulfur Rich Natural Substances
Organosulfur Compounds
Isothiocyanates
View the Evidence:
467 Abstracts with Sulforaphane Research
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[+]
Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.
Oct 17, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID:
29040973
Article Published Date
: Oct 17, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Sulforaphane
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients.
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2012 Nov ;63(7):767-71. Epub 2012 Apr 26. PMID:
22537070
Article Published Date
: Oct 31, 2012
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 2
,
Hyperinsulinism
,
Insulin Resistance
Pharmacological Actions
:
Antioxidants
,
Insulin Down-Regulation
[+]
Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(4):e0152895. Epub 2016 Apr 12. PMID:
27071063
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Anemia: Sickle Cell
Additional Keywords
:
Gene Expression Regulation
[+]
Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.
Dec 31, 2011
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID:
22045030
Article Published Date
: Dec 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Air Pollution Linked Toxicity
,
DNA damage
Additional Keywords
:
Isothiocyanates
[+]
Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.
Apr 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID:
19349290
Article Published Date
: Apr 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Broccoli Sprouts
,
Sprouts
,
Sulforaphane
Diseases
:
Gastritis
,
Helicobacter Pylori Infection
[+]
Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.
Apr 14, 2015
Click here to read the entire abstract
Pubmed Data
: Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID:
25466142
Article Published Date
: Apr 14, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Plant Extracts
[+]
Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.
May 11, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Prev Res (Phila). 2015 May 12. Epub 2015 May 12. PMID:
25968598
Article Published Date
: May 11, 2015
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate: PSA Doubling
,
Radical Prostatectomy
Additional Keywords
:
Recurrence Risk
,
Significant Treatment Outcome
[+]
Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.
Apr 23, 2018
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2018 Apr 24. Epub 2018 Apr 24. PMID:
29691233
Article Published Date
: Apr 23, 2018
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
[+]
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Autism. 2018 ;9:35. Epub 2018 May 30. PMID:
29854372
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autism Spectrum Disorders
Pharmacological Actions
:
Antioxidants
[+]
Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID:
19028145
Article Published Date
: Mar 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
COPD
,
Cystic Fibrosis
,
Glutathione Deficiency
,
Lung Diseases
,
Pulmonary Fibrosis
,
Respiratory Diseases
Pharmacological Actions
:
Antioxidants
,
Glutathione Upregulation
,
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Isothiocyanates
[+]
Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.
Nov 26, 2008
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID:
18950181
Article Published Date
: Nov 26, 2008
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Raw versus Cooked
[+]
Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2006;55(1):53-62. PMID:
16965241
Article Published Date
: Jan 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder.
Apr 28, 2020
Click here to read the entire abstract
Pubmed Data
: Psychiatry Clin Neurosci. 2020 Apr 29. Epub 2020 Apr 29. PMID:
32347624
Article Published Date
: Apr 28, 2020
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autism Spectrum Disorders
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution.
Jul 03, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID:
31268126
Article Published Date
: Jul 03, 2019
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Air Pollution Linked Toxicity
,
Benzene Toxicity
Pharmacological Actions
:
Antioxidant Effects
,
Detoxifier
Additional Keywords
:
Airborne Pollution
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Dose Response
,
Environmental Pollutant
,
Environmental Pollution
Problem Substances
:
Airborne Pollution
,
Benzene
[+]
Sulforaphane from broccoli was able to reduce some of the symptoms of autism.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Glob Adv Health Med. 2017 ;6:2164957X17735826. Epub 2017 Oct 26. PMID:
29147630
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autism
[+]
Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). I
Feb 01, 2007
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID:
17259330
Article Published Date
: Feb 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
,
Prostate Cancer
,
Prostate Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
,
Enzyme Inhibitors
,
Histone deacetylase inhibitor
[+]
Sulforaphane protects against chemically-induced damage in bladder cells and tissues.
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2003 Jan;17(1):66-9. PMID:
20810543
Article Published Date
: Jan 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Bladder Cancer
,
Bladder Degeneration
,
DNA damage
Pharmacological Actions
:
Chemopreventive
,
Genoprotective
[+]
Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Respir Res. 2015 ;16:106. Epub 2015 Sep 15. PMID:
26369337
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Asthma
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.
Apr 01, 2007
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID:
17416783
Article Published Date
: Apr 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Skin Diseases
Pharmacological Actions
:
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Plant Extracts
[+]
Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2014 Jan ;5(1):35-41. PMID:
24287881
Article Published Date
: Dec 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Diesel Exhaust Particle Toxicity
Pharmacological Actions
:
Anti-Allergic Agents
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.
Oct 27, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Proc Natl Acad Sci U S A. 2014 Oct 28 ;111(43):15550-5. Epub 2014 Oct 13. PMID:
25313065
Article Published Date
: Oct 27, 2014
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Isothiocyanates
,
Sulforaphane
Diseases
:
Autism Spectrum Disorders
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cytoprotective
,
Neuroprotective Agents
,
Nrf2 activation
Additional Keywords
:
Risk Factors
[+]
Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia.
Apr 29, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID:
25912539
Article Published Date
: Apr 29, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Schizophrenia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Plant Extracts
,
Significant Treatment Outcome
[+]
Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.
Nov 20, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID:
26604653
Article Published Date
: Nov 20, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Fatty Liver
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Plant Extracts
[+]
The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,
Jan 01, 2000
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2000;38(2):168-78. PMID:
11525594
Article Published Date
: Jan 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Raw versus Cooked
[+]
The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(11):e0140963. Epub 2015 Nov 2. PMID:
26524341
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Additional Keywords
:
Food Vs. Supplement
,
Increased Bioavailability
,
Plant Extracts
[+]
The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.
Feb 28, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Nutr Food Res. 2015 Mar ;59(3):424-33. Epub 2015 Jan 22. PMID:
25522265
Article Published Date
: Feb 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Absorption
,
Bioavailability
,
Dietary Modification
[+]
Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.
May 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Neuropsychiatry. 2018 May ;3(4):214-222. Epub 2018 Apr 17. PMID:
29888232
Article Published Date
: May 01, 2018
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Psychiatric Disorders
Pharmacological Actions
:
Glutathione Upregulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
psychiatric disorders
[+]
A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.
Mar 29, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID:
24742583
Article Published Date
: Mar 29, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Cancers: Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Chemotherapeutic
Additional Keywords
:
Cancer Stem Cells
,
Dietary Concentrations
[+]
Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:5263985. Epub 2018 Dec 17. PMID:
30647811
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Catechin
,
Sulforaphane
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Isothiocyanates
[+]
Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.
Jan 20, 2018
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2018 08 20 ;124:532-540. Epub 2018 Jun 30. PMID:
29969714
Article Published Date
: Jan 20, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidant Effects
,
Nrf2 activation
Additional Keywords
:
Antioxidants
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
[+]
Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.
Jan 15, 2018
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2018 08 15 ;353:23-30. Epub 2018 Jun 6. PMID:
29885333
Article Published Date
: Jan 15, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cadmium Poisoning
,
Cancers
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidant
,
Antioxidant Effects
,
Apoptotic
,
Autophagy Up-regulation
,
NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.
Jan 01, 2018
Click here to read the entire abstract
Pubmed Data
: Cells Tissues Organs. 2018 ;206(1-2):46-53. Epub 2018 Jul 24. PMID:
30041241
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Anti-cancer
,
Anti-metastatic
,
Anti-Proliferative
,
Cyclooxygenase 2 Inhibitors
,
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
[+]
Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:4125297. Epub 2018 Nov 18. PMID:
30581529
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Leukemia
Pharmacological Actions
:
Antioxidant
,
Antioxidant Effects
,
Antiproliferative
,
NADPH Oxidase Inhibitors
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Isothiocyanates
[+]
Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID:
30595796
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aging
,
Oxidative Stress
Pharmacological Actions
:
Nrf2 activation
Additional Keywords
:
calorie restriction
,
High Sugar Diet
,
Isothiocyanates
[+]
Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.
Sep 21, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2018 Sep 21 ;9(74):33982-33994. Epub 2018 Sep 21. PMID:
30338040
Article Published Date
: Sep 21, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Wnt/β-catenin pathway down-regulation
Additional Keywords
:
Anti-cancer
[+]
Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.
Dec 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FEBS Open Bio. 2018 Dec ;8(12):2022-2034. Epub 2018 Nov 14. PMID:
30524952
Article Published Date
: Dec 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Breast Cancer: Estrogen
Additional Keywords
:
Estrogen Positive Breast Cancer
,
Folate
,
Methylation
[+]
Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.
May 27, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 May 27 ;11(5). Epub 2019 May 27. PMID:
31137828
Article Published Date
: May 27, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Disorders
,
Insulin Resistance
Pharmacological Actions
:
Glucose Uptake Optimization
,
Insulin Sensitizers
Additional Keywords
:
Broccoli
,
Cruciferous Vegetables
,
glucose control
,
Glucose Uptake Enhancement
[+]
Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.
May 25, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 May 26. Epub 2015 May 26. PMID:
26008201
Article Published Date
: May 25, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Endothelial Damage
,
Endothelial Dysfunction
Pharmacological Actions
:
Antioxidants
,
Phase II Detoxification Enzyme Inducer
,
Superoxide Dismutase Up-regulation
[+]
Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.
Jul 08, 2019
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta Mol Basis Dis. 2019 Jul 8 ;1865(10):2586-2594. Epub 2019 Jul 8. PMID:
31295528
Article Published Date
: Jul 08, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Fetal Alcoholism
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
Additional Keywords
:
Alcohol
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Mesenchymal Stem Cells
,
Pregnancy And Fetal Growth
[+]
Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.
Aug 01, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Aug ;104:165-171. Epub 2018 May 15. PMID:
29772437
Article Published Date
: Aug 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 Nov-Dec;68(8):1338-1348. Epub 2016 Aug 16. PMID:
27636860
Article Published Date
: Oct 31, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Cytoprotective
,
Nrf2 activation
Additional Keywords
:
Gene Expression Regulation
,
Selective Cytotoxicity
[+]
Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.
Mar 11, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neuroinflammation. 2018 Mar 12 ;15(1):75. Epub 2018 Mar 12. PMID:
29530050
Article Published Date
: Mar 11, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro.
Aug 01, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2019 Aug ;70(5):570-578. Epub 2019 Jan 9. PMID:
30624124
Article Published Date
: Aug 01, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Gastric Cancer
,
Gastric Cancer: Prevention
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Anti-cancer
[+]
Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.
Jun 04, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2018 Jun 4 ;10(6). Epub 2018 Jun 4. PMID:
29866995
Article Published Date
: Jun 04, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforphane exhibits immunomodulatory properties on human placenta cells in vitro.
Feb 01, 2019
Click here to read the entire abstract
Pubmed Data
: J Reprod Immunol. 2019 Feb ;131:44-49. Epub 2018 Dec 29. PMID:
30641297
Article Published Date
: Feb 01, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immune Enhancing Properties
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Pregnancy
[+]
The addition of broccoli and watercress in the diet may reduce risk of breast cancer
Dec 01, 2005
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID:
15953625
Article Published Date
: Dec 01, 2005
Study Type
: Human In Vitro
Additional Links
Substances
:
Broccoli
,
Sulforaphane
,
Watercress
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.
Nov 01, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID:
30226534
Article Published Date
: Nov 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Female
,
Ovarian Cancer
Pharmacological Actions
:
Anti-Tumor
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
HER-2 oncoprotein down-regulation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug Synergy
,
Isothiocyanates
[+]
"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID:
23038615
Article Published Date
: Oct 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Erucin
,
Sulforaphane
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Chemopreventive
[+]
"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."
May 28, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2012 May 29. Epub 2012 May 29. PMID:
22641235
Article Published Date
: May 28, 2012
Study Type
: Insect Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Epstein-Barr Virus Infections
,
Nasopharyngeal Cancer
[+]
"Neuroprotective effects of sulforaphane after contusive spinal cord injury."
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Neurotrauma. 2012 Nov 1 ;29(16):2576-86. Epub 2012 Sep 20. PMID:
22853439
Article Published Date
: Oct 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Neuroprotective Agents
[+]
"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2012 ;2012:821936. Epub 2012 Sep 23. PMID:
23050040
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetic Nephropathy
[+]
"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."
Jun 30, 2012
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 2012 Jul ;222(1):37-45. Epub 2011 Dec 27. PMID:
22200890
Article Published Date
: Jun 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Amphetamine Addiction/Withdrawal
,
Brain: Microglial Activation
,
Neurodegenerative Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."
Nov 29, 2012
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2012 Nov 30. Epub 2012 Nov 30. PMID:
23201461
Article Published Date
: Nov 29, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemical Weapon Agent Injury
,
Skin Cancer: Prevention
Pharmacological Actions
:
Phase II Detoxification Enzyme Inducer
[+]
"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."
Sep 01, 2011
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID:
21617865
Article Published Date
: Sep 01, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
[+]
"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."
Aug 22, 2012
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID:
22950492
Article Published Date
: Aug 22, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aspirin-Induced Toxicity
,
NSAID-induced toxicity
[+]
Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice.
Oct 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Vet Sci. 2020 Nov ;21(6):e91. PMID:
33263238
Article Published Date
: Oct 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID:
29797311
Article Published Date
: Jan 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Stroke
Pharmacological Actions
:
Platelet aggregation inhibitor: collagen-induced aggregation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
[+]
Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.
Sep 28, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID:
16386831
Article Published Date
: Sep 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Isothiocyanates
,
Stilbenes
[+]
Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID:
19144376
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oxidative Stress
,
Petroleum Exposure And Toxicity
,
Polycyclic aromatic hydrocarbon (PAH) toxicity
Pharmacological Actions
:
Phase II Detoxification Enzyme Inducer
[+]
Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.
Oct 10, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Oct 11 ;39:134-144. Epub 2016 Aug 11. PMID:
27833054
Article Published Date
: Oct 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Depression
,
Depressive Disorder
,
Inflammation
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Risk Reduction
[+]
Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.
Jun 06, 2018
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID:
29730925
Article Published Date
: Jun 06, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Alcohol Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Malondialdehyde Down-regulation
,
Nrf2 activation
,
Phase II Detoxification Enzyme Inducer
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Plant Extracts
[+]
Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Pharm Res. 2009 Oct;26(10):2324-31. Epub 2009 Aug 8. PMID:
19669099
Article Published Date
: Oct 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Prostate Cancer
,
Prostate Cancer: Prevention
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Plant Extracts
[+]
Broccoli sprouts contain compounds which protect the skin against damage by UV radiation.
Oct 30, 2007
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23. PMID:
17956979
Article Published Date
: Oct 30, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Aging Skin
[+]
Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue.
Jul 01, 2007
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7. PMID:
17347138
Article Published Date
: Jul 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Brussel sprouts induce detoxifying enzymes.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2010 Aug 1;75(6):H190-9. PMID:
20722931
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Brussel sprouts
,
Sulforaphane
Diseases
:
Chemical Exposure
,
Intoxication
Pharmacological Actions
:
Phase I Detoxification Enzyme Inducer
,
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
Co-administration of SFN reversed the DOX-associated reduction in nuclear Nrf2 binding activity and restored cardiac expression of Nrf2-regulated genes, at both the RNA and protein levels.
May 25, 2015
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID:
26025579
Article Published Date
: May 25, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Chemoprotective Agents
,
Nrf2 activation
[+]
Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.
Jul 31, 2014
Click here to read the entire abstract
Pubmed Data
: Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID:
24758558
Article Published Date
: Jul 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Fig
,
Sulforaphane
,
Vitamin E
Diseases
:
Cadmium Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
Additional Keywords
:
Plant Extracts
Problem Substances
:
Cadmium
[+]
Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.
Jan 11, 2017
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID:
28089829
Article Published Date
: Jan 11, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Capsaicin
,
Piceatannol
,
Resveratrol
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemosensitizer
,
Chemotherapeutic
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
,
Natural Substance Synergy
[+]
Consumption of sulforaphane-enriched broccoli soup may inhibit bacterial growth in the stomach and upper small intestine.
Jul 09, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur J Nutr. 2020 Jul 10. Epub 2020 Jul 10. PMID:
32651764
Article Published Date
: Jul 09, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Escherichia coli Infections
Pharmacological Actions
:
Antimicrobial
[+]
Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2016 ;7(6):e2246. Epub 2016 Jun 2. PMID:
27253410
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Quercetin
,
Sulforaphane
Diseases
:
Cancers: Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(6):e0127244. Epub 2015 Jun 24. PMID:
26107664
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Cognitive Decline/Dysfunction
,
Neurologic Disorders
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
Additional Keywords
:
Plant Extracts
[+]
Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Hematol. 2019 09 ;77:51-60.e1. Epub 2019 Aug 9. PMID:
31404577
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Liver Damage
,
Sickle Cell Anemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
[+]
Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity.
Feb 15, 2017
Click here to read the entire abstract
Pubmed Data
: Diabetes. 2017 Feb 16. Epub 2017 Feb 16. PMID:
28209760
Article Published Date
: Feb 15, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Insulin Resistance
,
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Inhibitory effects of sulforaphane on NLRP3 inflammasome activation.
Jan 11, 2021
Click here to read the entire abstract
Pubmed Data
: Mol Immunol. 2021 12 ;140:175-185. Epub 2021 Oct 28. PMID:
34717147
Article Published Date
: Jan 11, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Epigenetic Modification
[+]
Isothiocyanates exhibit anti-myeloma activity.
Aug 01, 2011
Click here to read the entire abstract
Pubmed Data
: Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID:
21712538
Article Published Date
: Aug 01, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Isothiocyanate
,
Sulforaphane
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Apoptotic
[+]
Obesity may increase susceptibility to chronic pain often due to poor diet.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID:
29436058
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Ginseng
,
Resveratrol
,
Sulforaphane
Diseases
:
Chronic Pain
,
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Inflammatory Diet
,
Risk Factors
[+]
Oncogenic c-Myc is a target of sulforaphane to prevent and eliminate the onset of human prostate cancer.
Mar 14, 2016
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2016 Mar 15. Epub 2016 Mar 15. PMID:
26990292
Article Published Date
: Mar 14, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Cancer Stem Cells
[+]
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Sep 15, 2005
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2005 Sep 15;65(18):8548-57. PMID:
16166336
Article Published Date
: Sep 15, 2005
Study Type
: Animal Study
Additional Links
Substances
:
NAC (N-acetyl-L-cysteine)
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Lung Cancer
,
Nicotine/Tobacco Toxicity
,
Smoking
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Isothiocyanates
[+]
Pre-treatment with sulforaphane or thymoquinone can reduce acetylsalicylic acid-induced gastric ulcers.
Jun 14, 2016
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID:
27363643
Article Published Date
: Jun 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
,
Thymoquinone
Diseases
:
Gastric Ulcer
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Anti-Ulcer Agents
,
Antioxidants
,
Gastroprotective
[+]
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Apr 12, 2018
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2018 Apr 13. Epub 2018 Apr 13. PMID:
29668854
Article Published Date
: Apr 12, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Protective effects of sulforaphane and aerobic exercise on acute alcoholic hepatic injury in mice.
Oct 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Biol Sci. 2020 Nov ;27(11):3145-3149. Epub 2020 Jul 14. PMID:
33100876
Article Published Date
: Oct 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alcoholic Liver Disease
Therapeutic Actions
:
Exercise: Aerobic
Pharmacological Actions
:
Hepatoprotective
[+]
Protective effects of sulforaphane in experimental vascular cognitive impairment.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Cereb Blood Flow Metab. 2018 Jan 1:271678X18764083. Epub 2018 Jan 1. PMID:
29533123
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
,
Nrf2 activation
[+]
Protective effects of sulforaphane on exercise-induced organ damage via inducing antioxidant defense responses.
Feb 03, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2020 Feb 4 ;9(2). Epub 2020 Feb 4. PMID:
32033211
Article Published Date
: Feb 03, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
,
Muscle Damage: Exercise-Induced
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Metabolism. 2020 Jan ;102:154002. Epub 2019 Nov 9. PMID:
31706979
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cardiomyopathy
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
[+]
Sufloraphane has a protective effect on preserved pancreas and may have a potential clinical implication to improve hemodynamically unstable pancreas donor condition.
Jan 01, 2004
Click here to read the entire abstract
Pubmed Data
: Ann Transplant. 2004;9(3):68-71. PMID:
15759553
Article Published Date
: Jan 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions
:
Antioxidants
[+]
Suforaphane, a compound found within broccoli, inhibits lung metastasis induced by melanoma cells in tumor-bearing animals.
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID:
16600309
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Lung Cancer
,
Melanoma
,
Melanoma: Metastatic
Pharmacological Actions
:
Anti-metastatic
[+]
Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.
Jan 05, 2017
Click here to read the entire abstract
Pubmed Data
: J Neurosurg. 2017 Jan 6:1-12. Epub 2017 Jan 6. PMID:
28059653
Article Published Date
: Jan 05, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Antiproliferative
,
Apoptotic
,
Cancer Stem Cells
,
glioblastoma (GBM)
,
Sulforaphane
[+]
Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS.
Jul 02, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: AMB Express. 2020 Jul 3 ;10(1):119. Epub 2020 Jul 3. PMID:
32621086
Article Published Date
: Jul 02, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
[+]
Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.
Feb 18, 2019
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2019 Feb 19 ;364:213-224. Epub 2019 Feb 19. PMID:
30790585
Article Published Date
: Feb 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autism
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory: Th17 downregulation
,
Nrf2 activation
[+]
Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice.
Jun 30, 2019
Click here to read the entire abstract
Pubmed Data
: Biol Reprod. 2019 Jul 1 ;101(1):223-234. PMID:
31004475
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
High Fat Diet
,
Infertility: Male
Pharmacological Actions
:
Fertility Agents: Male
[+]
Sulforaphane ameliorates okadaic acid induced memory impairment in rats by activating the Nrf2/HO-1 antioxidant pathway.
Oct 02, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2015 Oct 3. Epub 2015 Oct 3. PMID:
26433376
Article Published Date
: Oct 02, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane ameliorates some features of clinical diabetic complications particularly the lipid profile and insulin responsiveness.
Apr 19, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Apr 20 ;7(4):2060-5. PMID:
27025193
Article Published Date
: Apr 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetic Complications
,
Insulin Resistance
Pharmacological Actions
:
Hypolipidemic
[+]
Sulforaphane and curcumin protect against malathion toxicity.
Jun 30, 2012
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID:
22957429
Article Published Date
: Jun 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Sulforaphane
Diseases
:
Malathion Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Sulforaphane and dibenzoylmethane alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers.
Oct 15, 2007
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2007 Oct 15;67(20):9937-44. PMID:
17942926
Article Published Date
: Oct 15, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Dibenzoylmethane (DBM)
,
Sulforaphane
Diseases
:
Adenomatous Polyposis Coli
,
Gastrointestinal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Chemopreventive
[+]
Sulforaphane and NAC (N-acetyl-L-cysteine) upregulate T(H)1 immunity in aging.
May 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Allergy Clin Immunol. 2008 May;121(5):1255-1261.e7. Epub 2008 Mar 5. PMID:
18325578
Article Published Date
: May 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
NAC (N-acetyl-L-cysteine)
,
Sulforaphane
Diseases
:
Aging
,
Immune Disorders: Low Immune Function
,
Immune Dysregulation: TH1/TH2 imbalance
,
Low Disorders: Low TH1
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
[+]
Sulforaphane and vitamin E could ameliorate cognitive decline and oxidative damage in pups with lead exposure at lactation from maternal milk.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: J Trace Elem Med Biol. 2017 Dec ;44:88-92. Epub 2017 Jun 15. PMID:
28965607
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
,
Vitamin E
Diseases
:
Cognitive Decline/Dysfunction
,
Lead Poisoning
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Lead
[+]
Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose.
Mar 17, 2020
Click here to read the entire abstract
Pubmed Data
: Neurochem Int. 2020 Mar 18:104728. Epub 2020 Mar 18. PMID:
32199985
Article Published Date
: Mar 17, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice.
Oct 03, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2017 Oct 4 ;51:69-79. Epub 2017 Oct 4. PMID:
29096318
Article Published Date
: Oct 03, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.
Feb 05, 2017
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID:
28176666
Article Published Date
: Feb 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aspirin-Induced Toxicity
,
Drug-Induced Toxicity: Indomethacin
,
Helicobacter Pylori Infection
,
NSAID-induced toxicity
Pharmacological Actions
:
Antioxidants
Problem Substances
:
Aspirin
,
Indomethacin
,
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]
Sulforaphane could inhibit inflammation in human umbilical vein ECs exposed to advanced glycation end products.
Apr 20, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2016 Apr 21. Epub 2016 Apr 21. PMID:
27212619
Article Published Date
: Apr 20, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Advanced Glycation End products (AGE)
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Sulforaphane could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat.
Aug 08, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2016 Aug 9 ;39(3):901-907. Epub 2016 Aug 9. PMID:
27497670
Article Published Date
: Aug 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes: Memory Problems
,
Diabetic Complications
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.
Aug 01, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2018 Aug ;41(4):1460-1476. PMID:
29704151
Article Published Date
: Aug 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 upregulation
,
Malonaldehyde (MDA) Down-Regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.
Feb 01, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID:
30597379
Article Published Date
: Feb 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
C-Reactive Protein
,
Diabetes Mellitus: Type 2
,
Dyslipidemias
,
Fatty Liver
,
Insulin Resistance
Pharmacological Actions
:
Hepatoprotective
,
Hypoglycemic Agents
,
Insulin Sensitizers
Additional Keywords
:
Isothiocyanates
Problem Substances
:
Fructose
[+]
Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.
Nov 15, 2005
Click here to read the entire abstract
Pubmed Data
: J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID:
16211562
Article Published Date
: Nov 15, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain Edema
,
Traumatic Brain Injury
[+]
Sulforaphane enhances leptin sensitivity and prevents weigh gain in diet-induced obese mice.
Sep 15, 2018
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2018 Sep 15 ;835:108-114. Epub 2018 Jul 29. PMID:
30063917
Article Published Date
: Sep 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Obesity
Additional Keywords
:
Body Mass Index (BMI)
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
,
leptin
[+]
Sulforaphane enhances lipid metabolism through improved mitochondrial function by Nrf-2 and PGC-1a-dependent mechanisms.
Jan 01, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2019 02 ;63(4):e1800795. Epub 2019 Jan 11. PMID:
30578708
Article Published Date
: Jan 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Mitochondrial Dysfunction
Pharmacological Actions
:
Lipolytic
,
Nrf2 activation
,
Peroxisome Proliferators
Additional Keywords
:
Mitochondria
,
mitochondria dysfunction
,
Mitochondrial Biogenesis
[+]
Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment.
May 23, 2021
Click here to read the entire abstract
Pubmed Data
: Physiol Behav. 2021 May 24 ;238:113467. Epub 2021 May 24. PMID:
34033847
Article Published Date
: May 23, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Dementia
,
Memory Disorders
,
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane enhances the anticancer activity of a chemo-agent against pancreatic cancer.
Aug 29, 2011
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2011 Aug 29. Epub 2011 Aug 29. PMID:
21875325
Article Published Date
: Aug 29, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug Synergy
[+]
Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.
Nov 01, 2008
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2008 Nov 1;14(21):6855-66. PMID:
18980980
Article Published Date
: Nov 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma.
Oct 03, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Oct 4 ;7(1):12651. Epub 2017 Oct 4. PMID:
28978924
Article Published Date
: Oct 03, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Liver Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Chemopreventive
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Sulforaphane exhibits antiproliferative, apoptotic, anti-inflammatory, and anti-angiogenic properties and ameliorates a rat model of endometriosis.
Apr 01, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID:
31217757
Article Published Date
: Apr 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Angiogenic
,
Anti Inflammatory
,
Antiproliferative
,
Apoptotic
,
Interferon Gamma Reducer
,
Interleukin-10 downregulation
,
PI3K-AKT inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Cytokines
,
Inflammation
,
Interleukin-6 Downregulation
,
women's health
[+]
Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.
Dec 01, 2006
Click here to read the entire abstract
Pubmed Data
: Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID:
16952200
Article Published Date
: Dec 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Adenomatous Polyposis Coli
,
Intestinal Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Sulforaphane has anticonvulsant properties and could improve mitochondrial function.
Sep 13, 2015
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2015 Sep 14. Epub 2015 Sep 14. PMID:
26365487
Article Published Date
: Sep 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Seizures
Pharmacological Actions
:
Anticonvulsants
,
Antioxidants
,
Nrf2 activation
[+]
Sulforaphane has antidepressant and anxiolytic like activities in stressed mice model of depression.
Dec 21, 2015
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2015 Dec 22 ;301:55-62. Epub 2015 Dec 22. PMID:
26721468
Article Published Date
: Dec 21, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Anxiety Disorders
,
Depression
Pharmacological Actions
:
Anti-Anxiety Agents
,
Anti-Inflammatory Agents
,
Antidepressive Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane has both anti-nociceptive and anti-inflammatory actions.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2017 Feb ;25(1):99-106. Epub 2017 Jan 4. PMID:
28054242
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Neuropathic Pain
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Sulforaphane has immunomodulatory properties.
Aug 01, 2007
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2007 Aug;14(7-8):538-45. Epub 2006 Nov 3. PMID:
17084602
Article Published Date
: Aug 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Immune Disorders: Low Immune Function
Pharmacological Actions
:
Immunomodulatory
[+]
Sulforaphane has potential as a therapeutic agent to protect T2DM patients from cognitive deficiencies.
Apr 19, 2018
Click here to read the entire abstract
Pubmed Data
: Neuroscience. 2018 Apr 20. Epub 2018 Apr 20. PMID:
29684505
Article Published Date
: Apr 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes: Cognitive Dysfunction
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane has preventive action in oxidative stress-mediated liver injury associated with acetaminophen (APAP)-induced toxicity.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2015 Jun ;80:193-200. Epub 2015 Mar 25. PMID:
25818464
Article Published Date
: May 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Sulforaphane has significant protective effects against oxidative stress and could ameliorate bladder dysfunction.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:7598294. Epub 2016 Jun 28. PMID:
27433291
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Bladder Dysfunction
,
Bladder Outlet Obstruction
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
[+]
Sulforaphane has the potential to prevent neuronal disorders by enhancing Brain-derived Neurotrophic Factor (BDNF) and its TrkB signaling pathways.
Jan 01, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2017 02 ;61(2). Epub 2016 Nov 30. PMID:
27735126
Article Published Date
: Jan 01, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Epigenetic Modification
,
Isothiocyanates
[+]
Sulforaphane improved cardiac function and remodelling by inhibiting oxidative stress and inflammation.
Mar 11, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2018 Mar 12 ;24:1473-1483. Epub 2018 Mar 12. PMID:
29527002
Article Published Date
: Mar 11, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Heart Failure
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
[+]
Sulforaphane improved islet function in vivo, indicating that combination of a free radical scavenger and an antioxidant (sulforaphane) may be used to increase the effectiveness of islet transplantation.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Muscle Nerve. 2010 Feb;41(2):185-90. PMID:
16504726
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Organ Transplantation
,
Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions
:
Anticarcinogenic Agents
[+]
Sulforaphane improves cognitive function administered following traumatic brain injury.
Aug 28, 2009
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2009 Aug 28;460(2):103-7. Epub 2009 Apr 15. PMID:
19515491
Article Published Date
: Aug 28, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Blood-Brain-Barrier Disorders
,
Brain Damage
,
Brain Injury: Traumatic
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Anticarcinogenic Agents
,
Neuroprotective Agents
[+]
Sulforaphane improves LPS-induced spatial learning and memory dysfunction, likely by upregulating neurogenesis through the BDNF-mTOR pathway.
Jan 15, 2018
Click here to read the entire abstract
Pubmed Data
: Neuroscience. 2018 09 15 ;388:357-366. Epub 2018 Aug 4. PMID:
30086367
Article Published Date
: Jan 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neurogenesis
Additional Keywords
:
Brain-derived neurotrophic factor modulator
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane improves neuronal mitochondrial function in brain tissue in acute carbon monoxide poisoning.
Dec 15, 2016
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2016 Dec 16. Epub 2016 Dec 16. PMID:
27983767
Article Published Date
: Dec 15, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Carbon Monoxide Poisoning
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury
Feb 08, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Feb 9 ;45:74-78. Epub 2017 Feb 9. PMID:
28189971
Article Published Date
: Feb 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-18 down-regulation
,
Interleukin-1 beta downregulation
[+]
Sulforaphane increases cell-mediated immune response in melanoma-induced metastatic tumor-bearing mice.
Apr 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Clin Invest. 2010 Apr 1;120(4):1043-55. Epub 2010 Mar 24. PMID:
17849266
Article Published Date
: Apr 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancer Metastasis
,
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Anticarcinogenic Agents
,
Interleukin-1 beta downregulation
,
Interleukin-2 upregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane increases the effectiveness of various cytotoxic drugs against pancreatic cancer stem cells without inducing additional toxicity in mice.
Jun 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2004 Summer;7(2):157-61. PMID:
20940707
Article Published Date
: Jun 01, 2004
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancers: Multi-Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Sulforaphane induced Nrf2 can alleviate muscle inflammation in mdx mice by inhibiting NF-κB signaling pathway.
May 25, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biol Chem. 2015 May 26. Epub 2015 May 26. PMID:
26013831
Article Published Date
: May 25, 2015
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Duchenne's Muscular Dystrophy
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Nrf2 activation
[+]
Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.
Nov 01, 2007
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2007 Nov;18(5):1263-8. PMID:
17914583
Article Published Date
: Nov 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane induces cell cycle arrest and programmed cell death in human lung cancer cells and retards growth of human lung cancer tumors in a xenograft animal model.
Oct 15, 2008
Click here to read the entire abstract
Pubmed Data
: J Nat Prod. 2008 Oct 15. Epub 2008 Oct 15. PMID:
18855447
Article Published Date
: Oct 15, 2008
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane induces cell death in primary human colorectal cancer.
Jan 01, 2012
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2012 ;2012:415231. Epub 2011 Jul 17. PMID:
21804859
Article Published Date
: Jan 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
[+]
Sulforaphane induces miR135b-5p and its target gene to inhibit the progression of pancreatic cancer.
Sep 26, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Ther Oncolytics. 2019 Sep 27 ;14:74-81. Epub 2019 Apr 6. PMID:
31044154
Article Published Date
: Sep 26, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
MicroRNA modulator
[+]
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.
May 28, 2002
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5. PMID:
12032331
Article Published Date
: May 28, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Gastric Cancer
,
Helicobacter Pylori Infection
Additional Keywords
:
Multi-Drug Resistant Pathogens
[+]
Sulforaphane inhibits multiple inflammasomes through a novel mechanism and contributes to our understanding of the beneficial effects of sulforaphane.
Aug 11, 2015
Click here to read the entire abstract
Pubmed Data
: J Leukoc Biol. 2015 Aug 12. Epub 2015 Aug 12. PMID:
26269198
Article Published Date
: Aug 11, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Gout
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Sulforaphane inhibits oral cancer cell growth in vitro and in an animal model.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Clin Biochem Nutr. 2010 Jan;46(1):60-7. Epub 2009 Dec 29. PMID:
20104266
Article Published Date
: Jan 01, 2010
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oral Cancer
Pharmacological Actions
:
Cell cycle arrest
[+]
Sulforaphane inhibits pancreatic cancer proliferation through AMPK activation and Nrf2 translocation in vitro and in vivo.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 ;50(3):1201-1215. Epub 2018 Oct 24. PMID:
30355942
Article Published Date
: Jan 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Anti-Tumor
,
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Nrf2 activation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in association with increased cytotoxicity of natural killer cells.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. PMID:
19223537
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancer Metastasis
,
Low Immune Function: Natural Killer Cells
,
Lung Cancer
,
Prostate Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
[+]
Sulforaphane inhibits respiratory syncytial virus replication and virus-induced inflammation in the lungs of mice.
Jan 15, 2009
Click here to read the entire abstract
Pubmed Data
: Am J Respir Crit Care Med. 2009 Jan 15;179(2):138-50. Epub 2008 Oct 17. PMID:
18931336
Article Published Date
: Jan 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oxidative Stress
,
Respiratory Syncytial Virus Infections
,
Respiratory Tract Infections
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Antiviral Agents
[+]
Sulforaphane inhibits the acquisition of tobacco smoke-induced lung cancer stem cell-like properties.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Theranostics. 2019 ;9(16):4827-4840. Epub 2019 Jul 9. PMID:
31367260
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lung Cancer
,
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Cancer Stem Cells
[+]
Sulforaphane inhibits vestibular schwannoma growth in vitro and in vivo.
Nov 01, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Nov 2 ;6:36215. Epub 2016 Aug 2. PMID:
27805058
Article Published Date
: Nov 01, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Schwannoma: Vestibular
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biomed Sci. 2015 ;22:38. Epub 2015 Jun 3. PMID:
26036303
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Chemotherapeutic
,
Epidermal growth factor receptor (EGFR) inhibitor
[+]
Sulforaphane is a promising agent to restore glucose tolerance through upregulation of insulin signaling in obese mice.
Sep 19, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 Sep 19 ;9(9):4695-4701. PMID:
30091431
Article Published Date
: Sep 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Glucose Uptake Optimization
,
Insulin Sensitizers
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
Problem Substances
:
Insulin
[+]
Sulforaphane is a protective agent against acetaminophen-induced liver damage.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Bratisl Lek Listy. 2017 ;118(8):453-459. PMID:
29050482
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis.
May 01, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID:
21278056
Article Published Date
: May 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aflatoxicosis
,
Liver Cancer
,
Liver Damage: Aflatoxin-Induced
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Problem Substances
:
Aflatoxin
[+]
Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID:
26531002
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
Prostaglandin PGE2 downregulation
[+]
Sulforaphane may be a potential compound that can inhibit Aβ oligomer production in Alzheimer's disease.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2018 ;62(4):1803-1813. PMID:
29614663
Article Published Date
: Dec 31, 2017
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane may have therapeutic value in the treatment of rheumatoid arthritis.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Arthritis Rheum. 2010 Jan;62(1):159-70. PMID:
20039434
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Interleukin-17 downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane may modulate serotonin levels.
Jul 01, 2008
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2008 Jul 1;68(13):5487-91. PMID:
18593952
Article Published Date
: Jul 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
,
Serotonin Disorders
Pharmacological Actions
:
Serotonergic
[+]
Sulforaphane might be a promising therapeutic agent for cognitive enhancement in Alzheimer's disease.
Jun 01, 2016
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2016 Jun 2. Epub 2016 Jun 2. PMID:
27255600
Article Published Date
: Jun 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane might emerge as a novel strategy to protect the bladder against ischemia-induced oxidative damage.
Nov 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Nov 8 ;6:36110. Epub 2016 Aug 8. PMID:
27824068
Article Published Date
: Nov 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Inhibitors
[+]
Sulforaphane normalizes intestinal flora and enhances gut barrier in mice with BBN-induced bladder cancer.
Jan 11, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2018 12 ;62(24):e1800427. Epub 2018 Nov 22. PMID:
30302904
Article Published Date
: Jan 11, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Gastrointestinal Agents
,
Interleukin-6 Downregulation
[+]
Sulforaphane normalizes the kidney epigenome and improves blood pressure in hypertensive rats.
Nov 03, 2011
Click here to read the entire abstract
Pubmed Data
: Am J Hypertens. 2011 Nov 3. Epub 2011 Nov 3. PMID:
22052072
Article Published Date
: Nov 03, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Hypertension
,
Kidney Diseases
Pharmacological Actions
:
Hypotensive
Additional Keywords
:
Epigenetic Modification
[+]
Sulforaphane offers protection against angiotensin II induced testicular injury.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2017 ;2017:5374897. Epub 2017 Jan 16. PMID:
28191275
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
,
Nrf2 activation
[+]
Sulforaphane potently induces phase 2 enzymes in bladder tissues and should be investigated as a bladder cancer preventive agent.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: BMC Cancer. 2006;6:62. Epub 2006 Mar 15. PMID:
16539699
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Phase II Detoxification Enzyme Inducer
[+]
Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling.
Oct 16, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Aging Cell. 2020 Oct 17:e13261. Epub 2020 Oct 17. PMID:
33067900
Article Published Date
: Oct 16, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aging: Heart
,
Cardiovascular Diseases
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Nrf2 activation
[+]
Sulforaphane prevents and/or retards adenoma formation in the gastrointestinal tract of mice.
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID:
16675473
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Adenomatous Polyposis Coli
,
Colorectal Cancer
,
Intestinal Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Chemopreventive
[+]
Sulforaphane prevents cell death and inflammation in nephropathy.
Jun 16, 2011
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID:
21684138
Article Published Date
: Jun 16, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Nephropathy
Pharmacological Actions
:
Renoprotective
Problem Substances
:
Cisplatin
Adverse Pharmacological Actions
:
Nephrotoxic
[+]
Sulforaphane prevents chemically-induced skin cancer in mice.
Aug 15, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2006 Aug 15;66(16):8293-6. PMID:
16912211
Article Published Date
: Aug 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Skin Cancer
,
Skin Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity.
Jan 06, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2016 Jan 7. Epub 2016 Jan 7. PMID:
26742517
Article Published Date
: Jan 06, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Mercury Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
,
Nrf2 activation
[+]
Sulforaphane prevents retinal ganglion cell death and acts as a potent neuroprotective modulator in retinal ischemia/reperfusion injury.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419861777. PMID:
31266422
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension.
Mar 31, 2020
Click here to read the entire abstract
Pubmed Data
: Am J Physiol Heart Circ Physiol. 2020 Apr 1 ;318(4):H853-H866. Epub 2020 Feb 28. PMID:
32108526
Article Published Date
: Mar 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Pulmonary Hypertension
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Nrf2 activation
[+]
Sulforaphane protects against benzo(a)pyrene induced toxicity.
Sep 15, 2010
Click here to read the entire abstract
Pubmed Data
: Pulm Pharmacol Ther. 2010 Sep 15. Epub 2010 Sep 15. PMID:
20833254
Article Published Date
: Sep 15, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Benzo[a]pyrene-induced Toxicity
Pharmacological Actions
:
Antioxidants
[+]
Sulforaphane protects against cadmium-induced testicular injury by activation of Nrf2-ARE pathway.
Jul 19, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2018 Jul 19 ;23(7). Epub 2018 Jul 19. PMID:
30029485
Article Published Date
: Jul 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Heavy Metal Toxicity
,
Oxidative Stress
,
Testicular Injury: Cadmium-Induced
Pharmacological Actions
:
Antioxidants
,
Apoptotic
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane protects against cisplatin-induced liver and mitochondrial damage.
Aug 15, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID:
21575670
Article Published Date
: Aug 15, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemically-Induced Liver Damage
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antineoplastic Agents
,
Antioxidants
Problem Substances
:
Cisplatin
Adverse Pharmacological Actions
:
Hepatotoxic
[+]
Sulforaphane protects against cisplatin-induced nephrotoxicity.
Aug 01, 2007
Click here to read the entire abstract
Pubmed Data
: Int J Sport Nutr Exerc Metab. 2007 Aug;17(4):352-63. PMID:
19913604
Article Published Date
: Aug 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antineoplastic Agents
,
Apoptotic
,
Renoprotective
[+]
Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.
Feb 15, 2009
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2009 Feb 15;235(1):57-67. Epub 2008 Nov 21. PMID:
19071154
Article Published Date
: Feb 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions
:
Apoptotic
,
NF-kappaB Inhibitor
Additional Keywords
:
Beta Cell Protection
,
Beta Cell Regeneration
[+]
Sulforaphane protects against diabetes-induced renal fibrosis through epigenetic up-regulation of BMP-7.
Jun 03, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Diabetes Metab J. 2021 Jun 4. Epub 2021 Jun 4. PMID:
34082508
Article Published Date
: Jun 03, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetic Nephropathy
,
Kidney Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Renoprotective
Additional Keywords
:
Epigenetic Modification
[+]
Sulforaphane protects against hypoxic-ischemic injury.
Jul 09, 2010
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID:
20417626
Article Published Date
: Jul 09, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cerebral Ischemia
,
Hypoxia
,
Stroke
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane protects against intermittent hypoxia-induced cardiomyopathy through Nrf2 activation.
Jan 10, 2018
Click here to read the entire abstract
Pubmed Data
: Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID:
30096613
Article Published Date
: Jan 10, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cardiomyopathy
,
Hypoxia
Pharmacological Actions
:
Antioxidant Effects
,
Metallothionein Up-regulation
,
Nrf2 activation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Jul 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2021 Aug ;24(2). Epub 2021 Jun 29. PMID:
34184072
Article Published Date
: Jul 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Antioxidants
,
Apoptotic
[+]
Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic Db/Db mice.
May 19, 2020
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2020 May 20 ;255:117823. Epub 2020 May 20. PMID:
32445760
Article Published Date
: May 19, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 2
,
Musculoskeletal Diseases
Pharmacological Actions
:
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Nrf2 activation
[+]
Sulforaphane protects ischemic injury of hearts.
Aug 11, 2008
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2008 Aug 11. PMID:
19948220
Article Published Date
: Aug 11, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Myocardial Infarction
,
Myocardial Ischemia
Pharmacological Actions
:
Antioxidants
[+]
Sulforaphane protects liver injury induced by intestinal ischemia in an animal model.
Jun 28, 2010
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2010 Jun 28;16(24):3002-10. PMID:
20572303
Article Published Date
: Jun 28, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Intestinal Diseases
,
Liver Disease
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
[+]
Sulforaphane protects piglet brains from neonatal hypoxic-ischemic injury.
Dec 09, 2020
Click here to read the entire abstract
Pubmed Data
: Dev Neurosci. 2020 Dec 10:1-11. Epub 2020 Dec 10. PMID:
33302269
Article Published Date
: Dec 09, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Ischemia
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
[+]
Sulforaphane protects the male reproductive system of mice from obesity-induced damage.
Oct 06, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Environ Res Public Health. 2019 Oct 7 ;16(19). Epub 2019 Oct 7. PMID:
31591291
Article Published Date
: Oct 06, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Hypogonadism
,
Obesity
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Nrf2 activation
[+]
Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents.
Jan 30, 2006
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2006 Jan 30;393(2-3):108-12. Epub 2005 Oct 17. PMID:
16233958
Article Published Date
: Jan 30, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cerebral Ischemia
,
Stroke: Recovery
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane reduces inflammation following spinal cord injury in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Ann Clin Lab Sci. 2010;40(4):354-60. PMID:
20947810
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane reduces the apoptosis of neurons in brain trauma-induced diffuse axonal injury.
Jun 23, 2019
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2019 Jun 24. Epub 2019 Jun 24. PMID:
31232487
Article Published Date
: Jun 23, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain Damage
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane significantly decreased leptin-induced vascular smooth muscle cell proliferation.
Mar 09, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Mar 10 ;32:73-84. Epub 2016 Mar 10. PMID:
27142739
Article Published Date
: Mar 09, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Atherosclerosis
,
Obesity
Pharmacological Actions
:
Leptin Down-Regulation
Anti Therapeutic Actions
:
Western Diet
[+]
Sulforaphane supplementation normalize endothelial dysfunction associated with type 2 diabetes.
Oct 29, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Oct 30 ;7(1):14357. Epub 2017 Oct 30. PMID:
29085055
Article Published Date
: Oct 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 2
,
Endothelial Dysfunction
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
[+]
Sulforaphane suppresses an animal model of skin cancer in a pleiotropic manner.
Jan 01, 2019
Click here to read the entire abstract
Pubmed Data
: Exp Dermatol. 2019 Jan ;28(1):28-34. Epub 2018 Dec 11. PMID:
30315662
Article Published Date
: Jan 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Skin Cancer: Prevention
Pharmacological Actions
:
Anti Inflammatory
,
Anticarcinogenic Agents
,
Antioxidant
,
Antioxidant Effects
,
Antiproliferative
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Ultraviolet Radiation Induced Damage
[+]
Sulforaphane suppresses LPS-induced inflammation in primary rat microglia, indicating it may have a therapeutic role in reducing brain inflammation.
Jun 01, 2010
Click here to read the entire abstract
Pubmed Data
: Inflamm Res. 2010 Jun;59(6):443-50. Epub 2009 Nov 19. PMID:
19924513
Article Published Date
: Jun 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain: Microglial Activation
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
[+]
Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells In vitro and in vivo.
Jan 23, 2019
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2019 Jan 24. Epub 2019 Jan 24. PMID:
30679159
Article Published Date
: Jan 23, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Chemotherapeutic
Additional Keywords
:
Cancer Stem Cells
[+]
Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Appl Physiol. 2009 Oct;107(4):1028-36. Epub 2009 Aug 27. PMID:
19713431
Article Published Date
: Oct 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Muscle Damage: Exercise-Induced
,
Muscle Fatigue
,
Muscle Soreness
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma.
Jul 14, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2019 Jul 15 ;855:276-284. Epub 2019 May 14. PMID:
31100413
Article Published Date
: Jul 14, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Asthma
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
,
Immunomodulatory: Th17 downregulation
,
Interleukin-23 Downregulation
,
Interleukin-6 Downregulation
[+]
Sulforaphane treatment upregulates CHIP and has the potential to decrease the accumulation of Aβ and tau in patients with Alzheimer's disease.
Apr 29, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2018 Apr 30:e1800240. Epub 2018 Apr 30. PMID:
29714053
Article Published Date
: Apr 29, 2018
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Heat Shock Protein Inducer
,
Neuroprotective Agents
[+]
Sulforaphane's anti-inflammatory, antioxidant, and neuroprotective benefits attentuate autoimmune encephalomyelitis in an animal model of Multiple Sclerosis.
Jul 22, 2019
Click here to read the entire abstract
Pubmed Data
: J Korean Med Sci. 2019 Jul 22 ;34(28):e197. Epub 2019 Jul 22. PMID:
31327180
Article Published Date
: Jul 22, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autoimmune Diseases
,
Multiple Sclerosis
Therapeutic Actions
:
anti-inflammatory
,
antioxidant
,
neuro-protective
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidant Effects
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
Additional Keywords
:
Antioxidant
,
Autoimmune Diseases
,
Cruciferous Vegetables
,
Multiple Sclerosis
,
Phytotherapy
,
Sulforaphane
[+]
Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts has profound anti-Helicobacter pylori activity in human gastric xenografts implanted in nude mice.
Dec 01, 2003
Click here to read the entire abstract
Pubmed Data
: Antimicrob Agents Chemother. 2003 Dec;47(12):3982-4. PMID:
14638516
Article Published Date
: Dec 01, 2003
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Helicobacter Pylori Infection
Additional Keywords
:
Plant Extracts
[+]
Sulforaphane-containing broccoli sprout extracts protect against UV-light-induced skin carcinogenesis.
Aug 28, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2006 Aug 28;240(2):243-52. Epub 2005 Nov 3. PMID:
16271437
Article Published Date
: Aug 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
DNA damage
,
Light Sensitivity
,
Oxidative Stress
,
Skin Diseases: Photo-Aging
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Radioprotective
Additional Keywords
:
Plant Extracts
[+]
Sulforphane attenuates oxidative stress and neuronal damage following traumatic brain injury.
Oct 18, 2010
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID:
20953205
Article Published Date
: Oct 18, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain Injury: Traumatic
,
Traumatic Brain Injury
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Temporal efficacy of a sulforaphane-based broccoli sprout diet in prevention of breast cancer through modulation of epigenetic mechanisms.
Jul 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Prev Res (Phila). 2018 Aug ;11(8):451-464. Epub 2018 May 15. PMID:
29764806
Article Published Date
: Jul 31, 2018
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: role in epigenetic regulation.
Jun 12, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2018 Jun 13 ;19(6). Epub 2018 Jun 13. PMID:
29899271
Article Published Date
: Jun 12, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Genistein
,
Sulforaphane
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antineoplastic Agents
,
Chemotherapeutic
,
Histone deacetylase inhibitor
Additional Keywords
:
Epigenetic Modification In Cancer
,
Natural Substance Synergy
[+]
The present study suggested that sulforaphane exerted a therapeutic effect in the atopic dermatitis.
Jul 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Aug ;20(2):1761-1771. Epub 2019 Jun 20. PMID:
31257541
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Atopic Dermatitis
Pharmacological Actions
:
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Nrf2 activation
[+]
The protective effects of sulforaphane on high-fat diet-induced obesity.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2021 ;12:665894. Epub 2021 Apr 29. PMID:
33995092
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
High Fat Diet
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.
Jun 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biochemistry (Mosc). 2020 Jul ;85(7):833-837. PMID:
33040727
Article Published Date
: Jun 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Resveratrol
,
Sulforaphane
Diseases
:
Coronavirus Infection
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Cytokine Storm
[+]
Young radish and sulforaphane protect against carbon tetrachloride-induced liver damage.
May 01, 2008
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. PMID:
18460814
Article Published Date
: May 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Radish
,
Sulforaphane
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Plant Extracts
[+]
Sulforaphane suppresses obesity-related glomerulopathy-induced damage by enhancing autophagy via Nrf2.
Jul 28, 2020
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2020 Jul 29 ;258:118153. Epub 2020 Jul 29. PMID:
32738361
Article Published Date
: Jul 28, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Obesity
Pharmacological Actions
:
Autophagy Up-regulation
Additional Keywords
:
Anti-Obesity Agents
[+]
The green anti-cancer weapon. the role of natural compounds in bladder cancer treatment.
Jul 20, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2021 Jul 21 ;22(15). Epub 2021 Jul 21. PMID:
34360552
Article Published Date
: Jul 20, 2021
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
Delphinidin
,
EGCG (Epigallocatechin gallate)
,
Gingerol
,
Quercetin
,
Resveratrol
,
Sulforaphane
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
[+]
"Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway."
Jun 30, 2012
Click here to read the entire abstract
Pubmed Data
: Cell Biochem Biophys. 2012 Jul ;63(3):247-59. PMID:
22565590
Article Published Date
: Jun 30, 2012
Study Type
: Commentary
Additional Links
Substances
:
Sulforaphane
Diseases
:
Glioma
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
NF-kappaB Inhibitor
[+]
"Sulforaphane and related mustard oils in focus of cancer prevention and therapy."
Dec 06, 2012
Click here to read the entire abstract
Pubmed Data
: Wien Med Wochenschr. 2012 Dec 7. Epub 2012 Dec 7. PMID:
23224634
Article Published Date
: Dec 06, 2012
Study Type
: Review
Additional Links
Substances
:
Cruciferous Vegetables
,
Mustard Oil
,
Sulforaphane
Diseases
:
Cancer Stem Cells
[+]
"Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90."
Nov 30, 2012
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2012 Dec ;23(12):1617-26. Epub 2012 Mar 23. PMID:
22444872
Article Published Date
: Nov 30, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Pancreatic Cancer
[+]
"Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways."
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2012 Nov ;28(5):1851-8. Epub 2012 Aug 22. PMID:
22922937
Article Published Date
: Oct 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Chemosensitizer
[+]
"Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells."
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Front Biosci (Elite Ed). 2011 ;3:515-28. Epub 2011 Jan 1. PMID:
21196331
Article Published Date
: Jan 01, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Quercetin
,
Sulforaphane
Diseases
:
Cancer Stem Cells
,
Pancreatic Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
Additional Keywords
:
Cancer Stem Cells
,
Drug Synergy
[+]
21 hTERT down-regulation by HDAC1 inhibition is a promising approach for delaying or preventing colorectal cancer.
Feb 04, 2017
Click here to read the entire abstract
Pubmed Data
: Curr Cancer Drug Targets. 2017 Feb 5. Epub 2017 Feb 5. PMID:
28176652
Article Published Date
: Feb 04, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Histone deacetylase inhibitor
,
MicroRNA modulator
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
A combination of benzyl isothiocyanate and sulforaphane have potent inhibitory activity in pancreatic cancer cells.
Dec 01, 2002
Click here to read the entire abstract
Pubmed Data
: Int J Cardiol. 2002 Dec;86(2-3):317-23. PMID:
19712481
Article Published Date
: Dec 01, 2002
Study Type
: In Vitro Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Natural Substance Synergy
[+]
A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds.
Jul 31, 2011
Click here to read the entire abstract
Pubmed Data
: Clin J Gastroenterol. 2011 Aug ;4(4):185-97. Epub 2011 Jun 4. PMID:
26189518
Article Published Date
: Jul 31, 2011
Study Type
: Review
Additional Links
Substances
:
Caffeine
,
Capsaicin
,
Cinnamaldehyde
,
Curcumin
,
Diallyl sulfide
,
EGCG (Epigallocatechin gallate)
,
Genistein
,
Lycopene
,
Resveratrol
,
Silymarin
,
Sulforaphane
,
Xanthohumol
Diseases
:
Liver Cancer
Pharmacological Actions
:
Chemopreventive
[+]
A review of the cardioprotective potential of plant-derived molecules.
Mar 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Dose Response. 2019 Apr-Jun;17(2):1559325819852243. Epub 2019 May 26. PMID:
31205459
Article Published Date
: Mar 31, 2019
Study Type
: Review
Additional Links
Substances
:
Catechin
,
Diosgenin
,
Isoflavones
,
Quercetin
,
Sulforaphane
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Cardioprotective
[+]
A variety of natural compounds may inhibit cancer stem cells.
Sep 01, 2011
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2011 Sep ;22(9):799-806. Epub 2011 Feb 4. PMID:
21295962
Article Published Date
: Sep 01, 2011
Study Type
: Review
Additional Links
Substances
:
Carotenoids
,
Catechin
,
Curcumin
,
Isoflavones
,
Lycopene
,
Piperidines
,
Resveratrol
,
Stilbenes
,
Sulforaphane
Diseases
:
Cancer Stem Cells
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
Additional Keywords
:
Cancer Stem Cells
[+]
Antineoplastic action of sulforaphane on HeLa cells by modulation of signaling pathways and epigenetic pathways.
Jun 10, 2021
Click here to read the entire abstract
Pubmed Data
: Minerva Med. 2021 Jun 11. Epub 2021 Jun 11. PMID:
34114450
Article Published Date
: Jun 10, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Aqueous extract of glucoraphanin-rich broccoli sprouts inhibits formation of advanced glycation end products and attenuates inflammatory reactions.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:9823141. Epub 2018 Aug 8. PMID:
30174716
Article Published Date
: Dec 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Advanced Glycation End products (AGE)
Pharmacological Actions
:
Anti-Glycation Agents
,
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Vojnosanit Pregl. 2016 Jul ;73(7):636-42. PMID:
29314795
Article Published Date
: Jun 30, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Cancers: All
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Chemopreventive
Additional Keywords
:
Isothiocyanates
[+]
Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas.
Aug 03, 2018
Click here to read the entire abstract
Pubmed Data
: Med Oncol. 2018 Aug 4 ;35(9):124. Epub 2018 Aug 4. PMID:
30078069
Article Published Date
: Aug 03, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Head and Neck Cancer
Pharmacological Actions
:
Chemosensitizer
,
Chemotherapeutic
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
[+]
Broccoli sprouts are an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Sep 16, 1997
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72. PMID:
9294217
Article Published Date
: Sep 16, 1997
Study Type
: In Vitro Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Isothiocyanates
[+]
Broccoli sprouts contains phytochemicals like sulforaphane which have anti-Helicobacter pylori activity.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2009 Jun;12(3):518-27. PMID:
20459098
Article Published Date
: Jun 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
Additional Keywords
:
Plant Extracts
[+]
Chemicals from the diet can influence the expression of functionally important long noncoding RNAs.
Jan 11, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2017 Jan 12 ;42:72-83. Epub 2017 Jan 12. PMID:
28131897
Article Published Date
: Jan 11, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemopreventive
,
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Chemoprevention of prostate cancer by natural agents: evidence from molecular and epidemiological studies.
Sep 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Anticancer Res. 2019 Oct ;39(10):5231-5259. PMID:
31570421
Article Published Date
: Sep 30, 2019
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Indole-3-Carbinol
,
Lycopene
,
Piperine
,
Quercetin
,
Resveratrol
,
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone.
Feb 26, 2019
Click here to read the entire abstract
Pubmed Data
: Cancer. 2019 Feb 27. Epub 2019 Feb 27. PMID:
30811596
Article Published Date
: Feb 26, 2019
Study Type
: Review
Additional Links
Substances
:
Piperine
,
Sulforaphane
,
Thymoquinone
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemotherapeutic
[+]
Combination of photodynamic therapy and Sulforaphane led to enhanced cytotoxic effect on head and neck cancer cells.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Gen Physiol Biophys. 2015 Jan ;34(1):13-21. Epub 2014 Nov 14. PMID:
25395599
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Head and Neck Cancer
Therapeutic Actions
:
Photodynamic therapy
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Cytotoxic
[+]
Combination treatment with resveratrol and sulforaphane induces programmed cell death in human glioma cells.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2010 Jan;35(1):152-61. Epub 2009 Aug 15. PMID:
19685289
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol
,
Sulforaphane
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Stilbenes
[+]
Combined Sulforaphane and selenium treatment resulted in a synergistic up-regulation of TrxR-1 that in part contributed to the enhanced protection against free radical-mediated cell death.
May 29, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2015 May 30. Epub 2015 May 30. PMID:
26094214
Article Published Date
: May 29, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Selenium
,
Sulforaphane
Diseases
:
Colon Cancer: Prevention
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords
:
Natural Substance Synergy
[+]
Combined treatment induced apoptosis more efficiently than either agent alone; however the most effective was a combination of lapatinib with erucin.
Jul 01, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 Jul 2:1-11. Epub 2015 Jul 2. PMID:
26134366
Article Published Date
: Jul 01, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Erucin
,
Sulforaphane
Diseases
:
Breast Cancer: HER-2 Overexpressed
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Drug: Allopurinol
,
Isothiocyanates
,
Natural Substance/Drug Synergy
[+]
Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome.
Feb 06, 2018
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2018 Feb 7. Epub 2018 Feb 7. PMID:
29427794
Article Published Date
: Feb 06, 2018
Study Type
: Review
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cardiovascular Diseases
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
NF-kappaB Inhibitor
[+]
Cruciferous vegetables are antioxidative, chemopreventive and antineoplasic functional foods against prostate cancers.
Jan 15, 2019
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Des. 2019 Jan 16. Epub 2019 Jan 16. PMID:
30652644
Article Published Date
: Jan 15, 2019
Study Type
: Review
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease.
Dec 17, 2020
Click here to read the entire abstract
Pubmed Data
: Nutr Rev. 2020 Dec 18. Epub 2020 Dec 18. PMID:
33338213
Article Published Date
: Dec 17, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Chronic Kidney Disease (CKD)
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
,
Renoprotective
[+]
Cyclin D1 is an important determinant of the therapeutic efficiency of Sulforaphane in A549 cells.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2016 Jun ;48(6):2521-33. Epub 2016 Mar 18. PMID:
27035641
Article Published Date
: May 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
[+]
Dietary isothiocyanates inhibit cancer progression by modulation of epigenome.
Jan 08, 2021
Click here to read the entire abstract
Pubmed Data
: Semin Cancer Biol. 2021 Jan 9. Epub 2021 Jan 9. PMID:
33434642
Article Published Date
: Jan 08, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Isothiocyanates
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
Dietary isothiocyanates, sulforaphane and 2-phenethyl isothiocyanate, effectively impair vibrio cholerae virulence.
Sep 21, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2021 Sep 22 ;22(19). Epub 2021 Sep 22. PMID:
34638525
Article Published Date
: Sep 21, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Cholera
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Dietary phytochemicals as neurotherapeutics for autism spectrum disorder: Plausible mechanism and evidence.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: Adv Neurobiol. 2020 ;24:615-646. PMID:
32006377
Article Published Date
: Dec 31, 2019
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
Naringenin
,
Resveratrol
,
Sulforaphane
Diseases
:
Autism Spectrum Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
,
Nrf2 activation
Additional Keywords
:
Gut-brain Axis
[+]
Dietary sulforaphane is a histone deacetylase inhibitor for cancer prevention.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. PMID:
19812222
Article Published Date
: Dec 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Enzyme Inhibitors
,
Histone deacetylase inhibitor
[+]
Effect of sulforaphane and 5-Aza-2'-deoxycytidine on melanoma cell growth.
Jun 26, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Medicines (Basel). 2019 Jun 27 ;6(3). Epub 2019 Jun 27. PMID:
31252639
Article Published Date
: Jun 26, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
Additional Keywords
:
Gene Expression
[+]
Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane.
Dec 31, 2020
Click here to read the entire abstract
Pubmed Data
: Oncol Lett. 2021 Jan ;21(1):71. Epub 2020 Nov 25. PMID:
33365082
Article Published Date
: Dec 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Cytotoxic
[+]
Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.
Mar 09, 2020
Click here to read the entire abstract
Pubmed Data
: Sci Total Environ. 2020 Mar 10 ;707:135624. Epub 2019 Nov 21. PMID:
31784171
Article Published Date
: Mar 09, 2020
Study Type
: Review
Additional Links
Substances
:
Sulforaphane
Diseases
:
Neurological Conditions
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
Additional Keywords
:
Isothiocyanates
[+]
Epigenome, transcriptome and protection by sulforaphane at different stages of UVB-induced skin carcinogenesis.
Mar 10, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Prev Res (Phila). 2020 Mar 11. Epub 2020 Mar 11. PMID:
32161072
Article Published Date
: Mar 10, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Skin Cancer
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anticarcinogenic Agents
[+]
Experimental data supports the bright future of natural polyphenols as anticancer tools.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:6475624. Epub 2015 Nov 16. PMID:
26649142
Article Published Date
: Dec 31, 2015
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Genistein
,
Polyphenols
,
Resveratrol
,
Sulforaphane
Diseases
:
Cancers: All
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
Gene targets of sulforaphane in head and neck squamous cell carcinoma.
Nov 30, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2019 Dec ;20(6):5335-5344. Epub 2019 Oct 23. PMID:
31661135
Article Published Date
: Nov 30, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Head and Neck Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Gene Expression Regulation
[+]
Given its anticarcinogenic, anti-inflammatory, antioxidant properties, these authors conclude that sulforaphane could be considered as a phytochemical at the forefront of natural medicine.
May 23, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 May 23 ;9(5):2589-2606. PMID:
29701207
Article Published Date
: May 23, 2018
Study Type
: Review
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancers
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Antioxidant Effects
,
Apoptotic
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
NF-kappaB Inhibitor
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Glucosinolate-degradation products as co-adjuvant therapy on prostate cancer in vitro.
Oct 08, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2019 Oct 9 ;20(20). Epub 2019 Oct 9. PMID:
31600887
Article Published Date
: Oct 08, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
,
Isothiocyanates
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Docetaxel
[+]
HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.
Apr 05, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2018 Apr 6. Epub 2018 Apr 6. PMID:
29633255
Article Published Date
: Apr 05, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Histone deacetylase inhibitor
[+]
Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways.
Mar 31, 2020
Click here to read the entire abstract
Pubmed Data
: J Asian Nat Prod Res. 2020 Apr ;22(4):386-396. Epub 2019 Mar 1. PMID:
30821482
Article Published Date
: Mar 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Liver Damage
,
Liver Failure: Acute
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
High levels of apoptosis are induced in the human colon cancer HT-29 cell line by co-administration of sulforaphane and a peptide nucleic acid.
Feb 16, 2020
Click here to read the entire abstract
Pubmed Data
: Nucleic Acid Ther. 2020 Feb 17. Epub 2020 Feb 17. PMID:
32069125
Article Published Date
: Feb 16, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
[+]
In this review, they discuss the biochemical and biological properties of sulforaphane with a particular emphasis on the anticancer properties of the dietary compound.
May 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxid Redox Signal. 2015 Jun 1 ;22(16):1382-424. Epub 2014 Dec 19. PMID:
25364882
Article Published Date
: May 31, 2015
Study Type
: Review
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancers: All
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Histone deacetylase inhibitor
,
NF-kappaB Inhibitor
,
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Dietary Concentrations
,
Selective Cytotoxicity
[+]
In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Curr Pharmacol Rep. 2015 May ;1(3):179-196. Epub 2015 Jan 30. PMID:
26457242
Article Published Date
: Apr 30, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemopreventive
,
MicroRNA modulator
,
Nrf2 activation
Additional Keywords
:
DNA Methylation
[+]
Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma.
Apr 30, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Pharm Sin B. 2021 May ;11(5):1246-1260. Epub 2020 Dec 15. PMID:
34094831
Article Published Date
: Apr 30, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Antiproliferative
[+]
Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation.
Apr 09, 2018
Click here to read the entire abstract
Pubmed Data
: Nucleosides Nucleotides Nucleic Acids. 2018 Apr 10:1-10. Epub 2018 Apr 10. PMID:
29634384
Article Published Date
: Apr 09, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemotherapeutic
Additional Keywords
:
Epigenetic Modification In Cancer
,
Natural Substance/Drug Synergy
,
Reactivation Of Tumor Suppressor Gene
[+]
Inhibitory effects of phytochemicals on NLRP3 inflammasome activation.
Aug 14, 2020
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2020 Aug 15 ;75:153238. Epub 2020 May 20. PMID:
32507349
Article Published Date
: Aug 14, 2020
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
Resveratrol
,
Sulforaphane
Diseases
:
Cardiovascular Diseases
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Isothiocyanate from broccoli, sulforaphane, and its properties.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2019 Feb ;22(2):121-126. Epub 2018 Oct 27. PMID:
30372361
Article Published Date
: Jan 31, 2019
Study Type
: Review
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Autism Spectrum Disorders
,
Cancers: All
,
Osteoporosis
Pharmacological Actions
:
Chemopreventive
,
Osteoprotective
[+]
Isothiocyanates could be potential agents for the prevention of C6 glioma cell migration and invasion.
Sep 17, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 Sep 18. Epub 2015 Sep 18. PMID:
26397194
Article Published Date
: Sep 17, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Isothiocyanates
,
Sulforaphane
Diseases
:
Glioma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro.
Mar 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2019 Apr ;43(4):e12802. Epub 2019 Feb 11. PMID:
31353575
Article Published Date
: Mar 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Lycopene
,
Quercetin
,
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Chemotherapeutic Synergy: Cisplatin
,
Natural Substance Synergy
[+]
Lyophilized broccoli sprouts may be effectively used in dietary chemoprevention.
May 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Plant Foods Hum Nutr. 2018 Jun ;73(2):95-100. PMID:
29675806
Article Published Date
: May 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Broccoli Sprouts
,
Isothiocyanates
,
Sulforaphane
Diseases
:
Colon Cancer
,
Liver Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Chemopreventive
[+]
MicroRNAs as novel targets of sulforaphane in cancer therapy.
Jan 22, 2020
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2020 Jan 23. Epub 2020 Jan 23. PMID:
31972874
Article Published Date
: Jan 22, 2020
Study Type
: Review
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemotherapeutic
,
MicroRNA modulator
[+]
Molecular mechanisms of the anti-cancer effects of isothiocyanates from cruciferous vegetables in bladder cancer.
Jan 28, 2020
Click here to read the entire abstract
Pubmed Data
: Molecules. 2020 Jan 29 ;25(3). Epub 2020 Jan 29. PMID:
32013065
Article Published Date
: Jan 28, 2020
Study Type
: Review
Additional Links
Substances
:
Benzyl isothiocyanate
,
Cruciferous Vegetables
,
Isothiocyanates
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Natural compounds against doxorubicin-induced cardiotoxicity.
Sep 27, 2020
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2020 Sep 28. Epub 2020 Sep 28. PMID:
32985744
Article Published Date
: Sep 27, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Alpha Linolenic Acid
,
Apigenin
,
Asiatic Acid
,
Ferulic acid
,
Genistein
,
Ginsenosides
,
Indole-3-Carbinol
,
Naringenin
,
P-Coumaric Acid
,
Punicalagin
,
Quercetin
,
Reishi Mushroom
,
Sulforaphane
,
Tanshinone IIA
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Chemoprotective Agents
,
Nrf2 activation
Additional Keywords
:
Polysaccharides
[+]
Noni contains an anthraquinone with potent quinone reductase-inducing (i.e. detoxifying) activity 40 times more potent than sufloraphane.
Dec 01, 2010
Click here to read the entire abstract
Pubmed Data
: Rejuvenation Res. 2010 Dec;13(6):749-54. PMID:
16378361
Article Published Date
: Dec 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Noni
,
Sulforaphane
Pharmacological Actions
:
Anticarcinogenic Agents
,
Quinone Reductase-Inducer
[+]
Nrf2 targeting by Sulforaphane could be a potential therapy for cancer treatment.
Dec 20, 2016
Click here to read the entire abstract
Pubmed Data
: Crit Rev Food Sci Nutr. 2016 Dec 21:0. Epub 2016 Dec 21. PMID:
28001083
Article Published Date
: Dec 20, 2016
Study Type
: Review
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancers: All
Pharmacological Actions
:
Nrf2 activation
[+]
Numerous nutrients and non-nutrient dietary bioactive components can reduce the occurrence and delay the development of liver cancer.
Jun 07, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 Jun 8:1-15. Epub 2016 Jun 8. PMID:
27266713
Article Published Date
: Jun 07, 2016
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
,
Sulforaphane
Diseases
:
Liver Cancer
,
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention.
Jun 30, 2021
Click here to read the entire abstract
Pubmed Data
: Pharmacol Ther. 2021 Jul ;223:107890. Epub 2021 May 14. PMID:
33992684
Article Published Date
: Jun 30, 2021
Study Type
: Review
Additional Links
Substances
:
Carnosine
,
Omega-3 Fatty Acids
,
Resveratrol
,
Sulforaphane
,
Vitamin C
,
Vitamin E
Diseases
:
Air Pollution Linked Toxicity
,
Cardiovascular Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Risk Factors
[+]
Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders.
Jan 31, 2020
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2020 Feb ;152:104579. Epub 2019 Nov 30. PMID:
31790820
Article Published Date
: Jan 31, 2020
Study Type
: Review
Additional Links
Substances
:
Luteolin
,
Omega-3 Fatty Acids
,
Probiotics
,
Sulforaphane
Diseases
:
Autism Spectrum Disorders
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane have a synergistic effect in the inhibition of inflammation.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Pharm Res. 2009 Jan;26(1):224-31. Epub 2008 Oct 8. PMID:
18841446
Article Published Date
: Jan 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Isothiocyanates
,
Natural Substance Synergy
[+]
Phytochemicals may serve as novel therapeutic agents for breast cancer treatment.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Semin Cancer Biol. 2016 Oct ;40-41:192-208. Epub 2016 Sep 5. PMID:
27609747
Article Published Date
: Sep 30, 2016
Study Type
: Review
Additional Links
Substances
:
6-Shogaol
,
Celastrol
,
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Epicatechin
,
Genistein
,
Indole-3-Carbinol
,
Isoliquiritigenin
,
Parthenolide
,
Pterostilbene
,
Quercetin
,
Resveratrol
,
Sulforaphane
,
Triptolide
,
Vitamin E
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Cancer Stem Cells
[+]
Phytochemicals which inhibit cancer stem cells may prove to be promising agents for the prevention and treatment of pancreatic cancers.
Jan 25, 2017
Click here to read the entire abstract
Pubmed Data
: Curr Med Chem. 2017 Jan 26. Epub 2017 Jan 26. PMID:
28137215
Article Published Date
: Jan 25, 2017
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Genistein
,
Indole-3-Carbinol
,
Quercetin
,
Resveratrol
,
Sulforaphane
,
Vitamin E: delta-tocopherol
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Cancer Stem Cells
[+]
Polyphenol antioxidants have properties to treat neurodegenerative diseases.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Basic Clin Neurosci. 2016 Apr ;7(2):81-90. PMID:
27303602
Article Published Date
: Mar 31, 2016
Study Type
: Review
Additional Links
Substances
:
Allicin
,
Carnosic Acid
,
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Isothiocyanate
,
Quercetin
,
Resveratrol
,
Rosmarinic acid
,
Sulforaphane
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Potential efficacy of sulforaphane and probably other bioactive components of young broccoli sprouts make it as an excellent choice for supplementary treatment in type 2 diabetes.
Apr 30, 2013
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2013 May ;16(5):375-82. Epub 2013 Apr 30. PMID:
23631497
Article Published Date
: Apr 30, 2013
Study Type
: Review
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 2
,
Diabetic Nephropathy
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
NF-kappaB Inhibitor
[+]
Pre-treatment with sulforaphane completely restored the antioxidant status and prevented inflammatory responses mediated by acrolein.
Jul 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arch Med Sci. 2016 Aug 1 ;12(4):871-80. Epub 2016 Jul 1. PMID:
27478470
Article Published Date
: Jul 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Nrf2 activation
[+]
Protective effect of isothiocyanates from cruciferous vegetables on breast cancer.
Sep 22, 2020
Click here to read the entire abstract
Pubmed Data
: Anticancer Agents Med Chem. 2020 Sep 23. Epub 2020 Sep 23. PMID:
32972351
Article Published Date
: Sep 22, 2020
Study Type
: Review
Additional Links
Substances
:
Cruciferous Vegetables
,
Isothiocyanates
,
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
,
Chemotherapeutic
[+]
Protective role of Nrf2 against ischemia reperfusion injury and cardiac allograft vasculopathy.
Nov 25, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Transplant. 2019 Nov 26. Epub 2019 Nov 26. PMID:
31769924
Article Published Date
: Nov 25, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Ischemia
Pharmacological Actions
:
Cardioprotective
,
Nrf2 activation
[+]
Radioprotection by repeated sulforaphane treatment was dose-dependent with an optimal effect at 10 uM, whereas both lower and higher concentrations resulted in lower levels of radioprotection.
Apr 30, 2014
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2014 May 1 ;276(3):188-94. Epub 2014 Mar 3. PMID:
24603300
Article Published Date
: Apr 30, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Isothiocyanates
,
Sulforaphane
Diseases
:
DNA damage
Pharmacological Actions
:
Nrf2 activation
,
Radioprotective
Additional Keywords
:
Dose Response
,
Ionizing Radiation
[+]
Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane.
Dec 30, 2019
