Sulforaphane

Name	AC	CK
Oxidative Stress	32	73
Prostate Cancer	23	38
Inflammation	14	36
Breast Cancer	24	31
Breast Cancer: Triple Negative	7	27
Colon Cancer	13	27
DNA damage	7	26
Pancreatic Cancer	15	24
Cancers: All	14	23
Autism Spectrum Disorders	2	20
Bladder Cancer	7	18
Helicobacter Pylori Infection	5	17
Diabetes Mellitus: Type 2	6	16
Melanoma	5	16
Insulin Resistance	3	14
Prostate Cancer: Prevention	4	14
Alzheimer's Disease	6	13
Liver Cancer	11	13
Lung Cancer	9	13
Autism	2	12
Diesel Exhaust Particle Toxicity	3	12
Glutathione Deficiency	3	12
Air Pollution Linked Toxicity	2	11
Cancer Metastasis	9	11
Skin Diseases	2	11
Anemia: Sickle Cell	1	10
Asthma	1	10
Bladder Degeneration	1	10
COPD	1	10
Cancers: Drug Resistant	5	10
Cognitive Decline/Dysfunction	5	10
Cystic Fibrosis	1	10
Fatty Liver	1	10
Gastritis	1	10
Hyperinsulinism	1	10
Lung Diseases	1	10
Prostate: PSA Doubling	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Schizophrenia	1	10
Lipopolysaccharide-Induced Toxicity	7	9
Endothelial Dysfunction	3	8
Cerebral Ischemia	4	7
Chemotherapy-Induced Toxicity: Cisplatin	4	7
Adenomatous Polyposis Coli	3	6
Chemically-Induced Liver Damage	4	6
Colorectal Cancer	4	6
Cancer Stem Cells	5	5
Chemotherapy-Induced Toxicity: Doxorubicin	4	5
Endothelial Damage	1	5
Glioblastoma	4	5
Hypoxia	4	5
Immune Disorders: Low Immune Function	3	5
Neurodegenerative Diseases	4	5
Ovarian Cancer	5	5
Acetaminophen (Tylenol) Toxicity	2	4
Aflatoxicosis	3	4
Aspirin-Induced Toxicity	2	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Cadmium Poisoning	3	4
Depression	2	4
Diabetic Complications	2	4
Gastric Cancer	3	4
Intestinal Polyps	2	4
Leukemia	4	4
NSAID-induced toxicity	2	4
Obesity	2	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Skin Cancer	3	4
Skin Cancer: Prevention	2	4
Spinal Cord Injuries	2	4
Traumatic Brain Injury	2	4
Advanced Glycation End products (AGE)	2	3
Aging Skin	2	3
Benzo[a]pyrene-induced Toxicity	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Brain Damage	2	3
Brain Inflammation	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Cardiovascular Diseases	3	3
Cervical Cancer	3	3
Chemotherapy-Induced Toxicity	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Diabetic Nephropathy	2	3
Drug-Induced Toxicity: Indomethacin	2	3
Gastric Ulcer	2	3
Head and Neck Cancer	3	3
Hydrogen Peroxide Induced Toxicity	3	3
Intestinal Diseases	2	3
Liver Damage: Aflatoxin-Induced	2	3
Low Disorders: Low TH1	2	3
Melanoma: Metastatic	2	3
Multiple Myeloma	2	3
Myocardial Ischemia	2	3
Nasopharyngeal Cancer	2	3
Oral Cancer	2	3
Osteosarcoma	2	3
Parkinson's Disease	3	3
Petroleum Exposure And Toxicity	2	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Rheumatoid Arthritis	2	3
Skin Diseases: Photo-Aging	2	3
Aging	1	2
Amphetamine Addiction/Withdrawal	1	2
Anxiety Disorders	1	2
Atherosclerosis	1	2
Bacterial Infections and Mycoses	2	2
Bladder Dysfunction	1	2
Bladder Outlet Obstruction	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Breast Cancer: Metastatic	2	2
Cancers: Multi-Drug Resistant	1	2
Carbon Monoxide Poisoning	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Memory Problems	1	2
Duchenne's Muscular Dystrophy	1	2
Epstein-Barr Virus Infections	1	2
Gastrointestinal Cancer	1	2
Glioma	2	2
Gout	1	2
Heart Failure	1	2
Hypertension	1	2
Hypoglycemia	2	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Intoxication	1	2
Ischemia	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Light Sensitivity	1	2
Liver Disease	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Mercury Poisoning	1	2
Muscle Damage: Exercise-Induced	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
Myocardial Infarction	1	2
Nephropathy	1	2
Neurologic Disorders	1	2
Neuropathic Pain	1	2
Nicotine/Tobacco Toxicity	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation	1	2
Promyelocytic leukemia	2	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Schwannoma: Vestibular	1	2
Seizures	1	2
Serotonin Disorders	1	2
Smoking	1	2
Stroke	1	2
Stroke: Recovery	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tumors	2	2
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Arsenic Poisoning	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Injury: Hippocampal Damage	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Prevention	1	1
Cardiac Hypertrophy	1	1
Cardiovascular Disease: Prevention	1	1
Cholesterol: LDL/HDL ratio	1	1
Colon Cancer: Prevention	1	1
Colorectal Tumors	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Dystrophic retinal detachment (DRD)	1	1
Encephalomyelitis	1	1
Excitotoxicity	1	1
Fibrosis	1	1
Fungal Infection	1	1
Gastrointestinal Diseases	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HDL: Low	1	1
HIV Infections	1	1
Hepatitis C	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
Hyperglycemia	1	1
IgE-Mediated Hypersensitivity	1	1
Keloid	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Liver Cancer: Prevention	1	1
Lung Cancer: Prevention	1	1
Macular Degeneration	1	1
Medulloblastoma	1	1
Melanism	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Multiple Sclerosis	1	1
Oral Cancer: Prevention	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Pesticide Toxicity	1	1
Prediabetes	1	1
Restenosis	1	1
Retinal Diseases	1	1
Stomach Cancer	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Antioxidants	69	166
Anticarcinogenic Agents	75	127
Apoptotic	81	120
Anti-Inflammatory Agents	41	105
Chemopreventive	51	99
Antiproliferative	47	81
Nrf2 activation	37	73
Neuroprotective Agents	32	63
Phase II Detoxification Enzyme Inducer	14	40
Cell cycle arrest	26	30
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	24
Chemotherapeutic	16	23
NF-kappaB Inhibitor	19	22
Cytoprotective	5	21
Hepatoprotective	8	21
Interleukin-1 beta downregulation	13	21
Histone deacetylase inhibitor	10	19
Anti-metastatic	15	18
Interleukin-6 Downregulation	12	17
Chemosensitizer	13	16
Cyclooxygenase 2 Inhibitors	13	16
Enzyme Inhibitors	7	16
Antineoplastic Agents	10	13
Glutathione Upregulation	3	12
Genoprotective	2	11
MicroRNA modulator	11	11
Anti-Allergic Agents	1	10
Cardioprotective	8	10
Insulin Down-Regulation	1	10
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	9
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	8
NF-E2-Related Factor-2 (Nrf2) Modulator	7	8
Anti-Apoptotic	4	7
Immunomodulatory	4	6
Renoprotective	4	6
Anti-Angiogenic	4	5
Heme oxygenase-1 up-regulation	5	5
Superoxide Dismutase Up-regulation	1	5
Antidepressive Agents	2	4
Antiviral Agents	3	4
Bcl-2 protein down-regulation	4	4
Anti-Bacterial Agents	3	3
Anti-Ulcer Agents	2	3
Chemoprotective Agents	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	3
Radioprotective	2	3
Telomerase Inhibitor	3	3
Tumor Suppressor Protein p53 Upregulation	3	3
Angiogenesis Inhibitors	1	2
Anti-Anxiety Agents	1	2
Anti-Fibrotic	2	2
Anticonvulsants	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Detoxifier	2	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Gastroprotective	1	2
Heat Shock Protein Inducer	1	2
Hypolipidemic	1	2
Hypotensive	1	2
Immunomodulatory: Th17 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 upregulation	1	2
Leptin Down-Regulation	1	2
Phase I Detoxification Enzyme Inducer	1	2
Prostaglandin PGE2 downregulation	1	2
Proteasome Inhibitors	2	2
Serotonergic	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Anti-Glycation Agents	1	1
Anti-Proliferative	1	1
Antifungal Agents	1	1
Antimitotic Agents	1	1
Autophagy Up-regulation	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
Cytotoxic	1	1
Estrogen Receptor Modulators	1	1
Hypoglycemic Agents	1	1
Interferon Gamma Reducer	1	1
Interleukin-10 upregulation	1	1
Interleukin-4 upregulation	1	1
Interleukin-8 downregulation	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Radiosensitizer	1	1
Survivin Down-Regulation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

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Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126

Article Published Date : Jul 03, 2019

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Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539

Article Published Date : Apr 29, 2015

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Schizophrenia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

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Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

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Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID: 30595796

Article Published Date : Jan 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Nrf2 activation

Additional Keywords : calorie restriction, High Sugar Diet, Isothiocyanates

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Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

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Pubmed Data : Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID: 30226534

Article Published Date : Nov 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Female, Ovarian Cancer

Pharmacological Actions : Anti-Tumor, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, HER-2 oncoprotein down-regulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Drug Synergy, Isothiocyanates

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"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

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Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615

Article Published Date : Oct 31, 2012

Study Type : Animal Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Bladder Cancer

Pharmacological Actions : Chemopreventive

[+]

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Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492

Article Published Date : Aug 22, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity

[+]

Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice.Oct 31, 2020

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Pubmed Data : J Vet Sci. 2020 Nov ;21(6):e91. PMID: 33263238

Article Published Date : Oct 31, 2020

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.Jan 01, 2018

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Pubmed Data : Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID: 29797311

Article Published Date : Jan 01, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Stroke

Pharmacological Actions : Platelet aggregation inhibitor: collagen-induced aggregation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables

[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

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Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

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Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925

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Pubmed Data : Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID: 26025579

Article Published Date : May 25, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation

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Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

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Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558

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Pubmed Data : Saudi J Biol Sci. 2020 Nov ;27(11):3145-3149. Epub 2020 Jul 14. PMID: 33100876

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Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.Aug 01, 2018

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Pubmed Data : Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151

Article Published Date : Aug 01, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Malonaldehyde (MDA) Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

[+]

Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.Feb 01, 2019

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Pubmed Data : Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379

Article Published Date : Feb 01, 2019

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Dyslipidemias, Fatty Liver, Insulin Resistance

Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents, Insulin Sensitizers

Additional Keywords : Isothiocyanates

Problem Substances : Fructose

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Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

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Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562

Article Published Date : Nov 15, 2005

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Brain Edema, Traumatic Brain Injury

[+]

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Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID: 31217757

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Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

Problem Substances : Insulin

[+]

Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

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Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis. May 01, 2011

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Pubmed Data : Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID: 21278056

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Pubmed Data : Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID: 16675473

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Adenomatous Polyposis Coli, Colorectal Cancer, Intestinal Polyps

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive

[+]

Sulforaphane prevents cell death and inflammation in nephropathy.Jun 16, 2011

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Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138

Article Published Date : Jun 16, 2011

[+]

Sulforaphane protects against cisplatin-induced liver and mitochondrial damage. Aug 15, 2011

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Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670

Article Published Date : Aug 15, 2011

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Pubmed Data : Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID: 20417626

Article Published Date : Jul 09, 2010

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Cerebral Ischemia, Hypoxia, Stroke

Pharmacological Actions : Neuroprotective Agents

[+]

Sulforaphane protects against intermittent hypoxia-induced cardiomyopathy through Nrf2 activation.Jan 10, 2018

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Pubmed Data : Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID: 30096613

Sulforaphane supplementation normalize endothelial dysfunction associated with type 2 diabetes.Oct 29, 2017

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Pubmed Data : Sci Rep. 2017 Oct 30 ;7(1):14357. Epub 2017 Oct 30. PMID: 29085055

Article Published Date : Oct 29, 2017

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Sulforaphane suppresses an animal model of skin cancer in a pleiotropic manner.Jan 01, 2019

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Pubmed Data : Exp Dermatol. 2019 Jan ;28(1):28-34. Epub 2018 Dec 11. PMID: 30315662

[+]

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts has profound anti-Helicobacter pylori activity in human gastric xenografts implanted in nude mice. Dec 01, 2003

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Pubmed Data : Antimicrob Agents Chemother. 2003 Dec;47(12):3982-4. PMID: 14638516

Article Published Date : Dec 01, 2003

Study Type : Transgenic Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Helicobacter Pylori Infection

Additional Keywords : Plant Extracts

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[+]

The present study suggested that sulforaphane exerted a therapeutic effect in the atopic dermatitis.Jul 31, 2019

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Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1761-1771. Epub 2019 Jun 20. PMID: 31257541

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Atopic Dermatitis

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.Jun 30, 2020

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Pubmed Data : Cell Biochem Biophys. 2012 Jul ;63(3):247-59. PMID: 22565590

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Pubmed Data : J Nutr Biochem. 2011 Sep ;22(9):799-806. Epub 2011 Feb 4. PMID: 21295962

Article Published Date : Sep 01, 2011

Study Type : Review

Additional Links

Substances : Carotenoids, Catechin , Curcumin, Isoflavones, Lycopene, Piperidines, Resveratrol, Stilbenes, Sulforaphane

Diseases : Cancer Stem Cells

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative

Additional Keywords : Cancer Stem Cells

[+]

Aqueous extract of glucoraphanin-rich broccoli sprouts inhibits formation of advanced glycation end products and attenuates inflammatory reactions.Dec 31, 2017

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Pubmed Data : Nutr Cancer. 2016 Jun 8:1-15. Epub 2016 Jun 8. PMID: 27266713

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Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder.Apr 28, 2020

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.May 01, 2018

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.Jan 01, 2018

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.Jan 15, 2018

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.Jan 01, 2018

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.Dec 01, 2018

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.May 25, 2015

Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.Jul 08, 2019

Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.Aug 01, 2018

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.Mar 11, 2018

Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro. Aug 01, 2019

Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.Jun 04, 2018

Sulforphane exhibits immunomodulatory properties on human placenta cells in vitro.Feb 01, 2019

The addition of broccoli and watercress in the diet may reduce risk of breast cancerDec 01, 2005

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."May 28, 2012

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."Dec 31, 2011

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."Jun 30, 2012

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."Sep 01, 2011

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."Aug 22, 2012

Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice.Oct 31, 2020

Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.Jan 01, 2018

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity. Mar 01, 2009

Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.Oct 10, 2016

Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.Jun 06, 2018

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.Oct 01, 2009

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation. Oct 30, 2007

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue. Jul 01, 2007

Brussel sprouts induce detoxifying enzymes. Aug 01, 2010

Co-administration of SFN reversed the DOX-associated reduction in nuclear Nrf2 binding activity and restored cardiac expression of Nrf2-regulated genes, at both the RNA and protein levels.May 25, 2015

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Consumption of sulforaphane-enriched broccoli soup may inhibit bacterial growth in the stomach and upper small intestine.Jul 09, 2020

Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.Dec 31, 2015

dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood. Dec 31, 2014

Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model.Dec 31, 2018

Sulforaphane

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452 Abstracts with Sulforaphane Research