Tanshinone IIA

Name	AC	CK	Focus
Hyperuricemia	1	2
Uric Acid Nephropathy	1	2

Name	AC	CK	Focus
NF-kappaB Inhibitor	1	2

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Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:7514046. Epub 2019 Dec 13. PMID: 31915451

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis

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Substances : Tanshinone IIA

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective

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Efficacy of tanshinone IIA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia.Dec 31, 2020

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Pubmed Data : J Tradit Chin Med. 2021 02 ;41(1):133-139. PMID: 33522206

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Pubmed Data : Dis Markers. 2021 ;2021:8740831. Epub 2021 Nov 29. PMID: 34880957

Article Published Date : Dec 31, 2020

Study Type : Human Study

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Substances : Tanshinone IIA

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective, MicroRNA modulator, Transforming growth factor beta (TGF-β) inhibitor

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Tanshinone IIA is a viable therapeutic option for regenerative medical approaches aimed at the treatment of periodontitis.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:9990937. Epub 2022 Nov 17. PMID: 36437835

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits.Jan 09, 2017

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Pubmed Data : Neurosci Lett. 2017 01 10 ;637:175-181. Epub 2016 Nov 11. PMID: 27845241

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Tanshinone IIA ameliorates nonalcoholic steatohepatitis.Dec 31, 2021

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:5769350. Epub 2022 Sep 1. PMID: 36091584

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Tanshinone IIA ameliorates streptozotocin-induced diabetic nephropathy.Dec 31, 2019

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Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:530-536. Epub 2018 May 25. PMID: 29800917

Article Published Date : Jul 31, 2018

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Anti-Apoptotic, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

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Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.Nov 30, 2021

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Pubmed Data : Int J Biol Sci. 2019 ;15(10):2211-2223. Epub 2019 Aug 19. PMID: 31592236

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Parasitic Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Remyelination

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Tanshinone IIA attenuates diabetic peripheral neuropathic pain.Dec 31, 2017

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Pubmed Data : Pharmacol Biochem Behav. 2015 Jan ;128:1-7. Epub 2014 Nov 6. PMID: 25449357

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Hyperalgesia, Neuropathic Pain, Oxidative Stress

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Tanshinone IIA attenuates paraquat‑induced acute lung injury.Aug 31, 2018

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Pubmed Data : Mol Med Rep. 2018 Sep ;18(3):2955-2962. Epub 2018 Jul 16. PMID: 30015919

Article Published Date : Aug 31, 2018

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Lung Injury: Acute, Pesticide Toxicity

Pharmacological Actions : Cytoprotective

Problem Substances : Paraquat

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Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway.Dec 31, 2019

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Pubmed Data : Oncol Rep. 2016 Aug ;36(2):1173-9. Epub 2016 Jun 7. PMID: 27277844

Article Published Date : Jul 31, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Tanshinone IIA

Diseases : Gastric Cancer

Pharmacological Actions : Chemotherapeutic

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Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.Nov 19, 2013

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Pubmed Data : Cell Physiol Biochem. 2015 ;35(5):1744-55. Epub 2015 Mar 23. PMID: 25832326

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Pubmed Data : Mol Med Rep. 2014 Aug ;10(2):689-94. Epub 2014 May 20. PMID: 24859152

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Pubmed Data : Inflammation. 2017 Oct ;40(5):1631-1642. PMID: 28646427

Article Published Date : Sep 30, 2017

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Brain Res. 2016 Jan 15 ;1631:137-46. Epub 2015 Dec 2. PMID: 26656068

Article Published Date : Jan 14, 2016

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Alzheimer's Disease

Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

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The protective effect of tanshinone IIA suppresses fibrosis in a rat model of cirrhosis.Mar 31, 2016

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Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2022 May 20 ;42(5):718-723. PMID: 35673916

Article Published Date : May 19, 2022

Study Type : Animal Study

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Substances : Tanshinone IIA

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

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A potential target of tanshinone IIA for acute promyelocytic leukemia revealed by inverse docking and drug repurposing.Dec 31, 2013

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Pubmed Data : Biomed Mater Eng. 2014 ;24(6):3815-24. PMID: 25227098

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

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Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights.Aug 31, 2021

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Inhibitory effect of tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.Mar 31, 2019

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Pubmed Data : J Recept Signal Transduct Res. 2019 Apr ;39(2):134-145. Epub 2019 Jul 29. PMID: 31354004

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants

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Inhibitory effect of tanshinone IIA on rat hepatic stellate cells.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(7):e103229. Epub 2014 Jul 30. PMID: 25076488

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Lipopolysaccharide-Induced Toxicity, Liver Steatosis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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Inhibitory effect of tanshinone IIA, resveratrol and silibinin on enterovirus 68 production through inhibiting ATM and DNA-PK pathway.Feb 18, 2022

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Pubmed Data : Molecules. 2023 Feb 20 ;28(4). Epub 2023 Feb 20. PMID: 36838978

Article Published Date : Feb 19, 2023

Study Type : Review

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Substances : Tanshinone IIA

Diseases : Acetaminophen (Tylenol) Toxicity , Diabetic Nephropathy, Kidney Cancer, Kidney Damage, Kidney Fibrosis

Pharmacological Actions : Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen

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Role of metastasis-related genes in cisplatin chemoresistance in gastric cancer.Dec 29, 2019

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Pubmed Data : Int J Mol Sci. 2019 Dec 30 ;21(1). Epub 2019 Dec 30. PMID: 31905926

Article Published Date : Dec 29, 2019

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Gene Expression Regulation

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Salvia miltiorrhiza for ankylosing spondylitis.Dec 31, 2021

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Tanshinone IIA activates autophagy to reduce liver ischemia-reperfusion injury.Dec 31, 2017

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Pubmed Data : Pharmazie. 2018 07 1 ;73(7):396-401. PMID: 30001774

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Liver Injury: Ischemia/reperfusion

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Autophagy Up-regulation, Hepatoprotective

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Pubmed Data : Curr Eye Res. 2017 12 ;42(12):1667-1673. Epub 2017 Sep 22. PMID: 28937825

Article Published Date : Jan 11, 2017

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Hypoxia, Macular Degeneration

Pharmacological Actions : Anti-Angiogenic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Tanshinone IIA could represent a promising candidate for heart failure therapy.Dec 31, 2015

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Tanshinone IIA exerts autophagic cell death through down-regulation of β-catenin in renal cell carcinoma cells.May 29, 2022

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Pubmed Data : Biochimie. 2022 May 30 ;200:119-130. Epub 2022 May 30. PMID: 35654241

Article Published Date : May 29, 2022

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Kidney Cancer

Pharmacological Actions : Apoptotic

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Tanshinone IIA exerts therapeutic effects by acting on endogenous stem cells in rats with liver cirrhosis.Nov 30, 2020

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Pubmed Data : Biomed Pharmacother. 2020 Dec ;132:110815. Epub 2020 Oct 28. PMID: 33113421

Article Published Date : Nov 30, 2020

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Liver Cirrhosis

Pharmacological Actions : Hepatoprotective

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View the Evidence: 429 Abstracts with Tanshinone IIA Research

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Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

Efficacy of tanshinone IIA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia.Dec 31, 2020

Tanshinone IIA could reduce the incidence of oxaliplatin induced peripheral neuropathy.Apr 30, 2016

Tanshinone IIA elevates serum soluble klotho levels and decreases cardiovascular events in patients on maintenance hemodialysis.Jun 30, 2020

Tanshinone IIA improves ventricular remodeling following cardiac infarction by regulating miR-205-3p.Dec 31, 2020

Tanshinone IIA is a viable therapeutic option for regenerative medical approaches aimed at the treatment of periodontitis.Dec 31, 2018

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease.Nov 30, 2022

Tanshinone IIA improves diabetes-induced renal fibrosis.Oct 31, 2022

Tanshinone IIA inhibits cardiomyocyte apoptosis and rescues cardiac function during doxorubicin-induced cardiotoxicity.Sep 20, 2022

Tanshinone IIA mediates protection from diabetes kidney disease.Nov 14, 2023

Tanshinone IIA microemulsion protects against cerebral ischemia reperfusion injury.Oct 02, 2022

Tanshinone IIA protected against lipopolysaccharide-induced brain injury.Jul 31, 2022

Tanshinone IIA regulates Keap1/Nrf2 signal pathway by activating sestrin2 to restrain pulmonary fibrosis.Oct 28, 2022

Tanshinone IIA regulates the TGF-β1/Smad signaling pathway to ameliorate non-alcoholic steatohepatitis-related fibrosis.Jun 30, 2022

"Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition."May 31, 2012

Anti-adipogenic effects on 3T3-L1 cells and zebrafish by tanshinone IIA.Sep 26, 2017

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test.Nov 30, 2017

Antinociceptive effects of systemic tanshinone IIA on visceral and somatic persistent nociception and pain hypersensitivity.Aug 31, 2014

Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury.Nov 30, 2022

Effect of tanshinone IIA for myocardial ischemia/reperfusion injury.Dec 31, 2022

Effect of tanshinone IIA on gut microbiome in diabetes-induced cognitive impairment.Dec 31, 2021

Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver.Oct 31, 2017

Improved tendon healing by a combination of tanshinone IIA and miR-29b inhibitor treatment.Dec 31, 2019

Lipophilic extract and tanshinone IIA derived from Salvia miltiorrhiza attenuate uric acid nephropathy.Dec 31, 2019

Mechanisms of Tanshinone II a inhibits malignant melanoma development through blocking autophagy signal transduction in A375 cell.Jan 21, 2017

Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure.Dec 31, 2018

Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctionsDec 31, 2017

Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury.Apr 30, 2017

Nrf2 activation contributes to tanshinone IIA-induced neuroprotection from experimental ischemic stroke.Jul 31, 2017

Post-conditioning with tanshinone IIA attenuates myocardial ischemia-reperfusion injury.Aug 31, 2014

Protective effect of tanshinone IIA on H2O2-induced oxidative stress injury.Feb 25, 2020

Protective effect of tanshinone IIA on the brain and its therapeutic time window in rat models of cerebral ischemia-reperfusion.Oct 31, 2014

Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury.Dec 31, 2014

Protective effects of Tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis.Jun 28, 2023

Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque.May 28, 2023

Reduction of atrial fibrillation by tanshinone IIA in chronic heart failure.Nov 30, 2016

Renoprotective effect of tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.Oct 19, 2022

Rescue therapy with tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease.Jan 17, 2016

Salvia miltiorrhiza and bioactive compound tanshinone IIA alleviates cisplatin-induced acute kidney injury.Dec 31, 2021

Sodium tanshinone IIA sulfonate as a potent IDO1/TDO2 dual inhibitor enhances anti-PD1 therapy for colorectal cancer.Dec 31, 2021

Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury.Apr 30, 2023

Sodium Tanshinone IIA sulfonate improves post-ischemic angiogenesis in hyperglycemia.Dec 09, 2019

Sodium tanshinone IIA sulfonate inhibits vascular endothelial cell pyroptosis.Dec 31, 2021

Study on the antioxidant effect of tanshinone IIA on diabetic retinopathy.Dec 31, 2021

Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits.Jan 09, 2017

tanshinone 2 A and resveratrol can improve the bone density and bone quality.Aug 29, 2018

Tanshinone could attenuate myocardial injury via upregulating the JAK2/STAT1 signaling pathway in this murine viral myocarditis model.Jan 31, 2015

Tanshinone II A affects diabetic peripheral neuropathic pain.Jul 10, 2019

Tanshinone II A can improve cardiac function, inhibit myocardial fibrosis and improve myocardial remodeling in rats with I/R-induced heart failure.May 31, 2022

Tanshinone IIA alleviates acute ethanol-induced myocardial apoptosis.Jun 23, 2021

Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder.Jun 24, 2020

Tanshinone IIA alleviates ovalbumin-induced allergic rhinitis symptoms.Nov 30, 2022

Tanshinone IIA alleviates oxidative damage after spinal cord injury in vitro and in vivo.Dec 31, 2018

Tanshinone IIA alleviates the damage of neurocytes by targeting GLUT1 in ischaemia reperfusion model.Dec 31, 2019

Tanshinone IIA alleviates vitiligo by suppressing AKT mediated CD8 + T cells activation.Aug 03, 2021

Tanshinone IIA ameliorate coxsackie virus B3-induced viral myocarditis. Dec 31, 2018

Tanshinone IIA ameliorates bleomycin-induced pulmonary fibrosis.Jun 30, 2015

Tanshinone IIA ameliorates chronic arthritis in mice by modulating neutrophil activities.Jan 09, 2017

Tanshinone IIA ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment.Nov 11, 2022

Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis.Nov 24, 2019

Tanshinone IIA ameliorates diabetic cardiomyopathy.Jun 30, 2019

Tanshinone IIA ameliorates experimental diabetic cardiomyopathy.Apr 30, 2023

Tanshinone IIA ameliorates inflammation response in osteoarthritis.Dec 31, 2020

Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury.Dec 31, 2021

Tanshinone IIA ameliorates nonalcoholic steatohepatitis.Dec 31, 2021

Tanshinone IIA ameliorates streptozotocin-induced diabetic nephropathy.Dec 31, 2019

Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition.Nov 30, 2019

Tanshinone IIA attenuated lipid deposition in the livers of hyperlipidemic rats.May 31, 2016

Tanshinone IIA attenuated neuronal apoptosis and improved learning and memory by suppressing endoplasmic reticulum stress activation.Jul 31, 2018

Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.Nov 30, 2021

Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation.Nov 15, 2020

Tanshinone IIA

View the Evidence:
429 Abstracts with Tanshinone IIA Research