Tanshinone IIA

Name	AC	CK
Oxidative Stress	30	57
Atherosclerosis	29	45
Myocardial Infarction	9	42
Inflammation	28	41
Liver Fibrosis	7	32
Alzheimer's Disease	18	31
Lipopolysaccharide-Induced Toxicity	22	31
Cerebral Ischemia	15	26
Diabetic Nephropathy	13	24
Myocardial Ischemia	14	24
Gastric Cancer	18	21
Angor Pectoris	1	20
Colorectal Cancer	16	19
Osteoarthritis	9	18
Sepsis	10	17
Carcinoma: Non-Small-Cell Lung	15	15
Cardiovascular Diseases	6	15
Liver Cancer	13	15
Hypoxia	11	14
Breast Cancer	12	13
Lung Cancer	12	13
Brain Inflammation	8	12
Cancers: Drug Resistant	11	12
Dementia	2	12
Heart Failure	7	12
Chemotherapy-Induced Toxicity: Oxaliplatin	2	11
Kidney Fibrosis	6	11
Lung Injury: Acute	7	11
Pulmonary Fibrosis	9	11
Chemotherapy-Induced Toxicity: Doxorubicin	6	10
Diabetic Neuropathies	1	10
Hemodialysis	1	10
Ischemia	5	10
Rheumatoid Arthritis	7	10
Spinal Cord Injuries	6	10
Cancers: All	7	9
Chemotherapy-Induced Toxicity: Bleomycin	5	9
Fibrosis	5	9
Lung Damage	6	9
Myocardial Fibrosis	6	9
Osteosarcoma	6	9
Cognitive Decline/Dysfunction	4	8
Diabetes Mellitus: Type 2	5	8
Diabetic Complications	5	8
Neuropathic Pain	4	8
Stroke: Ischemic	5	8
Cardiomyopathy	4	7
Nonalcoholic fatty liver disease (NAFLD)	4	7
Ovarian Cancer	6	7
Periodontitis	2	7
Prostate Cancer	6	7
Squamous cell carcinoma	6	7
Acetaminophen (Tylenol) Toxicity	4	6
Arthritis	3	6
Bladder Cancer	4	6
Brain Injury: Traumatic	3	6
Depression	3	6
Kidney Damage	4	6
Neurodegenerative Diseases	6	6
Asthma	2	5
Bone Fractures	3	5
Brain Ischemia	3	5
Cervical Cancer	5	5
Colon Cancer	4	5
Esophageal Cancer	5	5
Hydrogen Peroxide Induced Toxicity	4	5
Lipid Peroxidation	4	5
Obesity	3	5
Oral Cancer	3	5
Osteoporosis	4	5
Allergic Rhinitis	2	4
Cardiac Hypertrophy	3	4
Cardiomegaly	2	4
Chronic Kidney Disease (CKD)	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetic Neuropathy	2	4
Diabetic Retinopathy	3	4
Fatty Liver	3	4
Glioma	3	4
Hyperlipidemia	2	4
Hypertension	2	4
Hypertension: Pulmonary	2	4
Hyperuricemia	2	4
Memory Disorders	2	4
Multiple Sclerosis	2	4
Myocarditis: Viral	2	4
Nasopharyngeal Cancer	4	4
Nephropathy	2	4
Parkinson's Disease	3	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Sciatic Nerve Crush Injury	2	4
Acute lymphoblastic leukemia (ALL)	2	3
Breast Cancer: Triple Negative	3	3
Cancer Metastasis	3	3
Chemically-Induced Liver Damage	1	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Chronic Obstructive Pulmonary Disease	3	3
Colitis	2	3
Hyperalgesia	2	3
Leukemia: Acute myelogenous leukemia (AML)	3	3
Leukemia: Acute promyelocytic leukemia	2	3
Listeria Infections	1	3
Liver Steatosis	2	3
Melanoma	2	3
Pancreatitis	2	3
Stroke	2	3
Acrylamide-induced toxicity	1	2
Advanced Glycation End products (AGE)	2	2
Alcohol Toxicity	1	2
Allergies	1	2
Anaphylaxis	1	2
Autoimmune Diseases	2	2
Brain: Oxidative Stress	1	2
Cancer: Pain	1	2
Cerebral Aneurysm	1	2
Chemotherapy-Induced Kidney Damage	1	2
Cholesterol: Oxidation	2	2
Cirrhosis	1	2
Coronary Artery Disease	2	2
Coxsackievirus Infections	1	2
Embryo Transfer	1	2
Endometrial Cancer	1	2
Epilepsy	1	2
Fatigue: Excercise-Induced	1	2
Gastrointestinal Inflammation	1	2
Glomerulonephritis	1	2
High Fat Diet	1	2
Human Papillomavirus (HPV)	2	2
Ischemia: Myocardial	1	2
Kawasaki Disease	1	2
Kidney Cancer	2	2
Kidney Damage: Drug-Induced	1	2
Laryngeal Cancer	1	2
Lead Poisoning	1	2
Leukemia: Chronic myelogenous leukemia (CML)	2	2
Lung Inflammation	2	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocarditis	1	2
Neuromyelitis Optica	1	2
Pancreatic Cancer	2	2
Parasitic Diseases	1	2
Peripheral Arterial Disease	1	2
Peripheral Neuropathies	1	2
Peritonitis	1	2
Pesticide Toxicity	1	2
Polycystic Ovary Syndrome	1	2
Porphyromonas gingivalis	1	2
Promyelocytic leukemia	2	2
Scleroderma: Systemic	1	2
Seizures	1	2
Silicosis	1	2
Skin Cancer	1	2
Subarachnoid hemorrhage	1	2
Surgery: Anesthesiology	1	2
Tendon Injury	1	2
Traumatic Brain Injury	1	2
Uric Acid Nephropathy	1	2
Vitiligo	1	2
Wound Healing	1	2
Acne	1	1
Acute Myeloid Leukemia	1	1
Adenomyosis	1	1
Alzheimer's Disease: Homocysteine Associated	1	1
Astrocytoma	1	1
Cataract	1	1
Cerebral Palsy	1	1
Cerebrovascular Disorders	1	1
Chemotherapy and Radiation Toxicity	1	1
Cholangiocarcinoma	1	1
Chronic Myeloid Leukemia	1	1
Coronavirus Infection	1	1
Endometriosis	1	1
Endometritis	1	1
Endothelial Dysfunction	1	1
Enterovirus	1	1
Fluoride Toxicity	1	1
Glioblastoma	1	1
Glioblastoma Multiforme	1	1
HIV Infections	1	1
Head and Neck Cancer	1	1
Helicobacter Pylori Infection	1	1
Homocysteine: Elevated	1	1
Hypercholesterolemia	1	1
Inflammatory Bowel Diseases	1	1
Influenza A	1	1
Intracerebral Hemorrhage	1	1
Keloid	1	1
Liver Cirrhosis	1	1
Liver Damage	1	1
Liver Damage: Drug-Induced	1	1
Liver Disease	1	1
Liver Injury: Ischemia/reperfusion	1	1
Lung Injury: Smoke-Induced	1	1
Macular Degeneration	1	1
Mastitis	1	1
Mitochondrial Dysfunction	1	1
Muscle Disorders	1	1
Mycobacterium Tuberculosis	1	1
Otitis media	1	1
Pheochromocytoma	1	1
Pituitary Tumours	1	1
Psoriasis	1	1
Radiation	1	1
Radiotherapy	1	1
Respiratory Diseases	1	1
Scars	1	1
Schwannoma: Vestibular	1	1
Sleep Apnea: Obstructive	1	1
Spondylitis: Ankylosing	1	1
Tuberculosis Drug Induced Toxicity	1	1
Vascular Calcification	1	1

Name	AC	CK
Anti-Inflammatory Agents	144	253
Neuroprotective Agents	79	144
Cardioprotective	62	136
Antioxidants	66	130
Anti-Apoptotic	66	126
Antiproliferative	101	119
Apoptotic	93	105
Anti-Fibrotic	38	84
Tumor Necrosis Factor (TNF) Alpha Inhibitor	46	80
Interleukin-1 beta downregulation	39	67
Interleukin-6 Downregulation	40	65
NF-kappaB Inhibitor	41	65
MicroRNA modulator	36	57
Superoxide Dismutase Up-regulation	9	45
Hepatoprotective	15	43
Malondialdehyde Down-regulation	8	42
Chemoprotective Agents	15	33
Renoprotective	17	32
Chemosensitizer	28	30
Nrf2 activation	20	29
Transforming growth factor beta (TGF-β) inhibitor	11	28
Anti-metastatic	21	24
Autophagy Up-regulation	17	21
Cyclooxygenase 2 Inhibitors	12	17
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	11	16
Chemotherapeutic	11	15
Immunomodulatory	9	15
Cell cycle arrest	13	14
Angiogenesis Inhibitors	11	13
Bcl-2 protein down-regulation	9	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	8	12
Tumor Suppressor Protein p53 Upregulation	11	11
Analgesics	5	10
Hypolipidemic	6	10
Osteoprotective	7	10
Vascular Endothelial Growth Factor Inhibitors	10	10
Regenerative	3	9
Interleukin-18 down-regulation	4	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	8
Anti-atherogenic	4	7
Anti-Bacterial Agents	4	6
Antidepressive Agents	3	6
Antineoplastic Agents	6	6
Interleukin-10 upregulation	3	6
Angiogenesis Inducing Agents	3	5
Anti-Asthmatic Agents	2	5
Antinoceceptive	3	5
Brain-derived neurotrophic factor modulator	3	5
Chemopreventive	4	5
Heme oxygenase-1 up-regulation	4	5
Anticonvulsants	2	4
Gastrointestinal Agents	2	4
Interferon Gamma Reducer	2	4
Interleukin-2 Downregulation	2	4
Interleukin-4 upregulation	2	4
Radiosensitizer	3	4
Antiviral Agents	3	3
Autophagy Inhibitors	2	3
Chondroprotective	2	3
Immunomodulatory: Th17 downregulation	2	3
Interleukin-23 Downregulation	2	3
Interleukin-4 downregulation	2	3
Pancreato Protective Agents	1	3
Anti-Adipogenic	1	2
Anti-Allergic Agents	1	2
Anti-Angiogenic	2	2
Anti-Anxiety Agents	1	2
Anticholesteremic Agents	1	2
Antihypertensive Agents	1	2
Cytoprotective	1	2
Hypoglycemic Agents	1	2
Interleukin-1 beta upregulation	1	2
Interleukin-5 downregulation	1	2
Interleukin-8 downregulation	2	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
P21 Activation	2	2
Prophylactic Agents	1	2
Radioprotective	2	2
SIRT1 Activator	1	2
STAT3 Inhibitor	2	2
Survivin Down-Regulation	2	2
anti-inflammatory	1	2
Alpha-glucosidase inhibitor	1	1
Anti-HIV Agents	1	1
Antioxidant Effects	1	1
Cyclin D1 Down-Regulation	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Gastroprotective	1	1
Interleukin-10 downregulation	1	1
Interleukin-17 downregulation	1	1
Interleukin-18 upregulation	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
Neurogenesis	1	1
Nitric Oxide Enhancer	1	1
Photosensitizing Agents	1	1
Postaglandin PGE2 downregulation	1	1
Transforming growth factor beta (TGF-β) upregulation	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Efficacy of tanshinone IIA in rat models with myocardial ischemia-reperfusion injury.Dec 31, 2023

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Pubmed Data : Pak J Pharm Sci. 2024 May ;37(3):621-626. PMID: 39340853

Article Published Date : Apr 30, 2024

Study Type : Human Study

Additional Links

Substances : Tanshinone IIA

Diseases : Diabetic Neuropathies, Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

[+]

Efficacy of tanshinone IIA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia.Dec 31, 2020

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Pubmed Data : J Tradit Chin Med. 2021 02 ;41(1):133-139. PMID: 33522206

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Pubmed Data : Phytomedicine. 2025 Dec ;149:157548. Epub 2025 Nov 12. PMID: 41265260

Article Published Date : Nov 30, 2025

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor

[+]

Tanshinone IIA improves diabetes-induced renal fibrosis.Oct 31, 2022

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"Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition."May 31, 2012

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Pubmed Data : Planta Med. 2012 Jun ;78(9):866-73. Epub 2012 May 15. PMID: 22588836

Article Published Date : May 31, 2012

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hyperuricemia, Uric Acid Nephropathy

Pharmacological Actions : NF-kappaB Inhibitor

Additional Keywords : Drug: Allopurinol, Natural Substances Versus Drugs

Problem Substances : Allopurinol

[+]

Anti-adipogenic effects on 3T3-L1 cells and zebrafish by tanshinone IIA.Sep 26, 2017

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Pubmed Data : Cardiovasc Drugs Ther. 2023 Nov 22. Epub 2023 Nov 22. PMID: 37991600

Article Published Date : Nov 21, 2023

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

[+]

Lipophilic extract and tanshinone IIA derived from Salvia miltiorrhiza attenuate uric acid nephropathy.Dec 31, 2019

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Pubmed Data : Am J Chin Med. 2020 ;48(6):1455-1473. Epub 2020 Sep 15. PMID: 32933312

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hyperuricemia, Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors

[+]

Local application of tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing.May 22, 2024

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Pubmed Data : Heliyon. 2024 Apr 30 ;10(8):e29424. Epub 2024 Apr 9. PMID: 38638958

Article Published Date : Apr 29, 2024

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Neuroprotective effects of Tanshinone IIA in an acrylamide-induced in-vivo zebrafish model: Behavioral, biochemical and molecular restoration.Jan 31, 2026

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Pubmed Data : Tissue Cell. 2026 Feb ;98:103114. Epub 2025 Aug 29. PMID: 40896867

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Pubmed Data : J Recept Signal Transduct Res. 2020 Feb 26:1-9. Epub 2020 Feb 26. PMID: 32100629

Article Published Date : Feb 25, 2020

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Protective effect of tanshinone IIA on the brain and its therapeutic time window in rat models of cerebral ischemia-reperfusion.Oct 31, 2014

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Pubmed Data : Life Sci. 2019 Jan 1 ;216:147-155. Epub 2018 Nov 22. PMID: 30468834

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Oxidative Stress, Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Antioxidants, MicroRNA modulator

[+]

Tanshinone IIA alleviates the damage of neurocytes by targeting GLUT1 in ischaemia reperfusion model.Dec 31, 2019

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Pubmed Data : Folia Neuropathol. 2020 ;58(2):176-193. PMID: 32729296

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Stroke: Ischemic

Pharmacological Actions : Neuroprotective Agents

[+]

Tanshinone IIA alleviates traumatic brain Injury by reducing ischemia‒reperfusion.Dec 31, 2023

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Pubmed Data : Mediators Inflamm. 2024 ;2024:7459054. Epub 2024 Mar 21. PMID: 38549714

[+]

Tanshinone IIA ameliorates nonalcoholic steatohepatitis.Dec 31, 2021

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:5769350. Epub 2022 Sep 1. PMID: 36091584

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Tanshinone IIA ameliorates streptozotocin-induced diabetic nephropathy.Dec 31, 2019

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Pubmed Data : Neurosci Lett. 2025 Sep 22 ;867:138390. Epub 2025 Sep 22. PMID: 40992457

Article Published Date : Sep 21, 2025

Study Type : Animal Study

Additional Links

Substances : Safflower, Tanshinone IIA

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Tanshinone IIA attenuated lipid deposition in the livers of hyperlipidemic rats.May 31, 2016

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Pubmed Data : Int J Biol Sci. 2019 ;15(10):2211-2223. Epub 2019 Aug 19. PMID: 31592236

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Parasitic Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Remyelination

[+]

Tanshinone IIA attenuates diabetic peripheral neuropathic pain.Dec 31, 2017

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Pubmed Data : Pharmacol Biochem Behav. 2015 Jan ;128:1-7. Epub 2014 Nov 6. PMID: 25449357

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hyperalgesia, Neuropathic Pain, Oxidative Stress

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Tanshinone IIA attenuates paraquat‑induced acute lung injury.Aug 31, 2018

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Pubmed Data : Mol Med Rep. 2018 Sep ;18(3):2955-2962. Epub 2018 Jul 16. PMID: 30015919

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Lung Injury: Acute, Pesticide Toxicity

Pharmacological Actions : Cytoprotective

Problem Substances : Paraquat

[+]

Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway.Dec 31, 2019

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Pubmed Data : Int J Mol Med. 2023 Nov ;52(5). Epub 2023 Oct 6. PMID: 37800609

Article Published Date : Oct 31, 2023

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Tanshinone IIA could be a promising agent for painful diabetic neuropathy treatment.Oct 31, 2018

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Pubmed Data : Oncol Rep. 2016 Aug ;36(2):1173-9. Epub 2016 Jun 7. PMID: 27277844

Article Published Date : Jul 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Gastric Cancer

Pharmacological Actions : Chemotherapeutic

[+]

Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.Nov 19, 2013

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Pubmed Data : Phytomedicine. 2025 Aug ;144:156946. Epub 2025 Jun 3. PMID: 40499218

Article Published Date : Jul 31, 2025

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Embryo Transfer, Oxidative Stress

Pharmacological Actions : Anti-Anxiety Agents, Antioxidants

[+]

Tanshinone IIA improves acute gouty arthritis.Dec 31, 2021

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Pubmed Data : Arch Biochem Biophys. 2023 Jul 15 ;743:109655. Epub 2023 Jun 5. PMID: 37285895

Article Published Date : Jul 14, 2023

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Endometrial Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Tanshinone IIA inhibits human prostate cancer cells growth.Nov 30, 2013

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Pubmed Data : Cell Physiol Biochem. 2015 ;35(5):1744-55. Epub 2015 Mar 23. PMID: 25832326

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Pubmed Data : Mol Med Rep. 2014 Aug ;10(2):689-94. Epub 2014 May 20. PMID: 24859152

Article Published Date : Jul 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD-mediated pyroptosis.Nov 30, 2025

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Pubmed Data : Oncotarget. 2018 Jan 12 ;9(4):4511-4521. Epub 2017 Dec 17. PMID: 29435120

Article Published Date : Jan 11, 2018

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Cerebral Ischemia

Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents

[+]

Anti-inflammatory mechanism research of tanshinone II A by module-based network analysis.Dec 31, 2013

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Pubmed Data : Biomed Mater Eng. 2014 ;24(6):3815-24. PMID: 25227098

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights.Aug 31, 2021

[+]

Harnessing the therapeutic value of Tanshinone IIA: a breakthrough therapy in cardiovascular diseases.Dec 31, 2024

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Pubmed Data : J Recept Signal Transduct Res. 2019 Apr ;39(2):134-145. Epub 2019 Jul 29. PMID: 31354004

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Inhibitory effect of tanshinone IIA on rat hepatic stellate cells.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(7):e103229. Epub 2014 Jul 30. PMID: 25076488

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Lipopolysaccharide-Induced Toxicity, Liver Steatosis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Inhibitory effect of tanshinone IIA, resveratrol and silibinin on enterovirus 68 production through inhibiting ATM and DNA-PK pathway.Feb 18, 2022

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Pubmed Data : J Tradit Chin Med. 2023 Oct ;43(5):1040-1046. PMID: 37679993

Article Published Date : Sep 30, 2023

Study Type : Review

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Substances : Tanshinone IIA

Diseases : Sepsis

Pharmacological Actions : Anti-Bacterial Agents

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Renoprotective effects of tanshinone IIA: A literature review. Feb 19, 2023

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Pubmed Data : Molecules. 2023 Feb 20 ;28(4). Epub 2023 Feb 20. PMID: 36838978

Article Published Date : Feb 19, 2023

Study Type : Review

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Substances : Tanshinone IIA

Diseases : Acetaminophen (Tylenol) Toxicity , Diabetic Nephropathy, Kidney Cancer, Kidney Damage, Kidney Fibrosis

Pharmacological Actions : Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen

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Role of metastasis-related genes in cisplatin chemoresistance in gastric cancer.Dec 29, 2019

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Pubmed Data : Int J Mol Sci. 2019 Dec 30 ;21(1). Epub 2019 Dec 30. PMID: 31905926

Article Published Date : Dec 29, 2019

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Gene Expression Regulation

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Salvia miltiorrhiza for ankylosing spondylitis.Dec 31, 2021

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Pubmed Data : Int Heart J. 2024 ;65(4):730-737. PMID: 39085112

Article Published Date : Dec 31, 2023

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Oxidative Stress, Radiation

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective

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Sodium tanshinone IIA sulphate inhibits angiogenesis in lung adenocarcinoma.Nov 30, 2023

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Pubmed Data : Pharm Biol. 2023 Dec ;61(1):868-877. PMID: 37300283

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Pubmed Data : Biomed Pharmacother. 2021 Feb 9 ;137:111353. Epub 2021 Feb 9. PMID: 33578236

Article Published Date : Feb 08, 2021

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Lipopolysaccharide-Induced Toxicity, Mastitis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Tanshinone I improves TNBC chemosensitivity by suppressing late-phase autophagy through AKT/p38 MAPK signaling pathway.Jul 31, 2024

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Pubmed Data : Biomed Pharmacother. 2024 Aug ;177:117037. Epub 2024 Jul 2. PMID: 38959602

Article Published Date : Jul 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells.Apr 29, 2020

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Pubmed Data : Biosci Rep. 2020 Apr 30 ;40(4). PMID: 32232409

Article Published Date : Apr 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

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View the Evidence: 544 Abstracts with Tanshinone IIA Research

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Efficacy of tanshinone IIA in rat models with myocardial ischemia-reperfusion injury.Dec 31, 2023

Dose-related efficacy and safety of sodium tanshinone II A sulfonate for the treatment of unstable angina pectoris.Mar 05, 2025

Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

Effect analysis of tanshinone IIA sulfonate sodium combined with a-lipoic acid in patients with diabetes peripheral neuropathy.Apr 30, 2024

Efficacy of tanshinone IIA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia.Dec 31, 2020

Tanshinone IIA could reduce the incidence of oxaliplatin induced peripheral neuropathy.Apr 30, 2016

Tanshinone IIA elevates serum soluble klotho levels and decreases cardiovascular events in patients on maintenance hemodialysis.Jun 30, 2020

Tanshinone IIA improves ventricular remodeling following cardiac infarction by regulating miR-205-3p.Dec 31, 2020

Tanshinone IIA facilitates efficient cartilage regeneration under inflammatory factors caused stress.Dec 11, 2023

Tanshinone IIA is a viable therapeutic option for regenerative medical approaches aimed at the treatment of periodontitis.Dec 31, 2018

Anticancer effects of tanshinone IIA in bladder urothelial carcinoma.Apr 30, 2024

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease.Nov 30, 2022

Protective effect of tanshinone IIA against Listeria monocytogenes infection.Oct 14, 2025

Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation.Sep 12, 2023

Tanshinone IIA alleviates liver fibrosis by suppressing hepatic stellate cell proliferation.Dec 31, 2024

Tanshinone IIA ameliorates pancreatic injury in type 2 diabetic mice.Oct 09, 2025

Tanshinone IIA attenuates airway inflammation and airway remodeling in bronchial asthma.Jan 19, 2026

Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation.Nov 30, 2025

Tanshinone IIA improves diabetes-induced renal fibrosis.Oct 31, 2022

Tanshinone IIA inhibits cardiomyocyte apoptosis and rescues cardiac function during doxorubicin-induced cardiotoxicity.Sep 20, 2022

Tanshinone IIA inhibits heat-induced growth of p53-mutant Huh-7 hepatocellular carcinoma.Oct 30, 2025

Tanshinone IIA mediates protection from diabetes kidney disease.Nov 14, 2023

Tanshinone IIA microemulsion protects against cerebral ischemia reperfusion injury.Oct 02, 2022

Tanshinone IIA protected against lipopolysaccharide-induced brain injury.Jul 31, 2022

Tanshinone IIA regulates CCl4 induced liver fibrosis in C57BL/6J mice.Jan 31, 2024

Tanshinone IIA regulates Keap1/Nrf2 signal pathway by activating sestrin2 to restrain pulmonary fibrosis.Oct 28, 2022

Tanshinone IIA regulates the TGF-β1/Smad signaling pathway to ameliorate non-alcoholic steatohepatitis-related fibrosis.Jun 30, 2022

"Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition."May 31, 2012

Anti-adipogenic effects on 3T3-L1 cells and zebrafish by tanshinone IIA.Sep 26, 2017

Anti-inflammatory and antiresorptive activities of tanshinone-IIA mitigate alveolar bone destruction in mice with experimental periodontitis.Sep 30, 2025

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test.Nov 30, 2017

Antinociceptive effects of systemic tanshinone IIA on visceral and somatic persistent nociception and pain hypersensitivity.Aug 31, 2014

Cardiomyoprotective effect of Tanshinone IIA in diabetic cardiomyopathy.Jul 28, 2025

Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury.Nov 30, 2022

Effect of tanshinone IIA for myocardial ischemia/reperfusion injury.Dec 31, 2022

Effect of tanshinone IIA on gut microbiome in diabetes-induced cognitive impairment.Dec 31, 2021

Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver.Oct 31, 2017

Effects and mechanisms of Salvia miltiorrhiza Bunge extract on myocardial cell apoptosis in rat heart failure model.Dec 31, 2023

Improved tendon healing by a combination of tanshinone IIA and miR-29b inhibitor treatment.Dec 31, 2019

Intervention of tanshinone IIA on the PGK1-PDHK1 pathway to reprogram macrophage phenotype after myocardial infarction.Nov 21, 2023

Lipophilic extract and tanshinone IIA derived from Salvia miltiorrhiza attenuate uric acid nephropathy.Dec 31, 2019

Local application of tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing.May 22, 2024

Mechanisms of Tanshinone II a inhibits malignant melanoma development through blocking autophagy signal transduction in A375 cell.Jan 21, 2017

Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure.Dec 31, 2018

Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctionsDec 31, 2017

Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury.Apr 30, 2017

Neuroprotective effect of tanshinone IIA-modified mesenchymal stem cells in a lipopolysaccharide-induced neuroinflammation model.Apr 29, 2024

Neuroprotective effects of Tanshinone IIA in an acrylamide-induced in-vivo zebrafish model: Behavioral, biochemical and molecular restoration.Jan 31, 2026

Nrf2 activation contributes to tanshinone IIA-induced neuroprotection from experimental ischemic stroke.Jul 31, 2017

Post-conditioning with tanshinone IIA attenuates myocardial ischemia-reperfusion injury.Aug 31, 2014

Protective effect of tanshinone IIA on H2O2-induced oxidative stress injury.Feb 25, 2020

Protective effect of tanshinone IIA on the brain and its therapeutic time window in rat models of cerebral ischemia-reperfusion.Oct 31, 2014

Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury.Dec 31, 2014

Protective effects of Tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis.Jun 28, 2023

Protective effects of Tanshinone IIA preconditioning against hypobaric hypoxia-induced lung injury in a rat model.Sep 30, 2025

Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque.May 28, 2023

Reduction of atrial fibrillation by tanshinone IIA in chronic heart failure.Nov 30, 2016

Renoprotective effect of tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.Oct 19, 2022

Rescue therapy with tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease.Jan 17, 2016

Salvia miltiorrhiza and bioactive compound tanshinone IIA alleviates cisplatin-induced acute kidney injury.Dec 31, 2021

Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy.Jan 29, 2024

Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1.Aug 31, 2025

Sodium tanshinone IIA sulfonate as a potent IDO1/TDO2 dual inhibitor enhances anti-PD1 therapy for colorectal cancer.Dec 31, 2021

Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury.Apr 30, 2023

Sodium Tanshinone IIA sulfonate improves post-ischemic angiogenesis in hyperglycemia.Dec 09, 2019

Sodium tanshinone IIA sulfonate inhibits tumor growth via miR-138 upregulation in intermittent hypoxia-induced xenograft mice.Feb 07, 2024

Sodium tanshinone IIA sulfonate inhibits vascular endothelial cell pyroptosis.Dec 31, 2021

Study on the antioxidant effect of tanshinone IIA on diabetic retinopathy.Dec 31, 2021

Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits.Jan 09, 2017

tanshinone 2 A and resveratrol can improve the bone density and bone quality.Aug 29, 2018

Tanshinone could attenuate myocardial injury via upregulating the JAK2/STAT1 signaling pathway in this murine viral myocarditis model.Jan 31, 2015

Tanshinone IIA

View the Evidence:
544 Abstracts with Tanshinone IIA Research