Tetrahydrocurcumin

Name	AC	CK
Oxidative Stress	22	39
Diabetes Mellitus: Type 2	10	20
Inflammation	7	11
Breast Cancer	5	9
Nonalcoholic fatty liver disease (NAFLD)	4	8
Obesity	4	7
Cervical Cancer	3	6
High Fat Diet	3	6
Traumatic Brain Injury	3	6
Lipid Peroxidation	3	5
Aging	2	4
Hyperglycemia	2	4
Hypertension	2	4
Lipopolysaccharide-Induced Toxicity	3	4
Metabolic Diseases	3	4
Myocardial Infarction	2	4
Breast Cancer: Triple Negative	1	3
Cadmium Poisoning	2	3
Cardiac Hypertrophy	2	3
Influenza	2	3
Liver Cancer	3	3
Neurodegenerative Diseases	2	3
Parkinson's Disease	2	3
Ultraviolet Radiation Induced Damage	2	3
Aging Skin	1	2
Altitude Sickness	1	2
Alzheimer's Disease	2	2
Antibiotic Toxicity	1	2
Arsenic Poisoning	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Brain Inflammation	1	2
Brain Injury: Traumatic	2	2
Brain Ischemia	1	2
Cancers: All	2	2
Cardiomyopathy	1	2
Cardiovascular Diseases	1	2
Chemically-Induced Liver Damage	2	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Vincristine	1	2
Colon Cancer	1	2
Depression	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Kidney Function	1	2
Diabetes: Liver Disease	1	2
Diabetic Nephropathy	1	2
Dyslipidemias	1	2
Epstein-Barr Virus Infections	1	2
Fatty Liver	1	2
Fibrosis	1	2
Fungus Diseases	1	2
Gastric Ulcer	1	2
Glioma	2	2
Hepatic Steatosis	1	2
High Fructose Diet	1	2
Hypoxia: Brain	1	2
Insulin Resistance	1	2
Iron Overload	1	2
Kidney Damage	1	2
Kidney Damage: Chemically-Induced	2	2
Leukemia	1	2
Osteoarthritis	1	2
Phthalate Toxicity	1	2
Postmenopausal Disorders	1	2
Spinal Cord Injuries	1	2
Stroke: Ischemic	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tumors	1	2
Acetaminophen (Tylenol) Toxicity	1	1
Acute Myeloid Leukemia	1	1
Brain: Oxidative Stress	1	1
Cancer Metastasis	1	1
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cerebral Ischemia	1	1
Colorectal Cancer	1	1
Esophageal Cancer	1	1
Eye Damage	1	1
Eye Diseases	1	1
Fibrosarcoma	1	1
HIV Infections	1	1
Homocysteine: Elevated	1	1
Influenza A	1	1
Liver Damage: Drug-Induced	1	1
Lung Cancer	1	1
Neurological Conditions	1	1
Oral Cancer	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1
Pseudomonas aeruginosa	1	1
Psoriasis	1	1
Radiation Induced Illness	1	1
Skin Diseases	1	1
Squamous cell carcinoma	1	1

Name	AC	CK
Antioxidants	34	57
Anti-Inflammatory Agents	20	35
Neuroprotective Agents	16	25
Apoptotic	14	23
Antiproliferative	11	17
Hepatoprotective	10	17
Anti-Apoptotic	9	15
Cardioprotective	7	12
Renoprotective	7	12
Anticarcinogenic Agents	6	11
Hypolipidemic	5	9
Cell cycle arrest	3	8
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	8
Antihypertensive Agents	4	7
Caspase-3 Activation	2	6
Cyclooxygenase 2 Inhibitors	3	6
Gastrointestinal Agents	3	6
Hypoglycemic Agents	3	6
Angiogenesis Inhibitors	3	5
Bcl-2 protein down-regulation	1	5
Nrf2 activation	3	5
P21 Activation	1	5
Anti-Fibrotic	2	4
Anti-metastatic	4	4
Antiviral Agents	3	4
Chemoprotective Agents	2	4
Chemotherapeutic	3	4
Interleukin-6 Downregulation	2	4
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	4
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	4
Superoxide Dismutase Up-regulation	2	4
Vascular Endothelial Growth Factor Inhibitors	2	4
Heme oxygenase-1 up-regulation	2	3
Malondialdehyde Down-regulation	2	3
Photoprotective	2	3
Anti-Angiogenic	1	2
Anti-Ulcer Agents	1	2
Antidepressive Agents	1	2
Antifungal Agents	1	2
Antineoplastic Agents	2	2
Antinoceceptive	1	2
Brain-derived neurotrophic factor modulator	1	2
Chemopreventive	2	2
Gastroprotective	1	2
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-5 downregulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
NF-kappaB Inhibitor	1	2
Anti-Bacterial Agents	1	1
Autophagy Inhibitors	1	1
Caspase-9 Activation	1	1
Chemosensitizer	1	1
Cyclin D1 Down-Regulation	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Radiosensitizer	1	1

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Short-term intravenous dosing of liposomal curcumin appears to be safe up to a dose of 120 mg/m2.Dec 31, 2014

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Pubmed Data : Int J Clin Pharmacol Ther. 2015 Jan ;53(1):54-65. PMID: 25500488

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Curcumin: Lipidated, Tetrahydrocurcumin

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Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

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Pubmed Data : Food Chem Toxicol. 2014 May ;67:193-200. Epub 2014 Mar 1. PMID: 24593988

Article Published Date : Apr 30, 2014

Study Type : Human In Vitro

Additional Links

Substances : Curcumin: Degradiation byproducts, Tetrahydrocurcumin

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, P21 Activation

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Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis.Dec 31, 2024

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Pubmed Data : Saudi Pharm J. 2023 Sep ;31(9):101727. Epub 2023 Aug 2. PMID: 37638219

Article Published Date : Aug 31, 2023

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin

Diseases : Hyperglycemia

Pharmacological Actions : Hypoglycemic Agents

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Supplementation with tetrahydrocurcumin enhances the therapeutic effects of dexamethasone in a murine model of allergic asthma.Dec 31, 2019

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Pubmed Data : Int Arch Allergy Immunol. 2020 ;181(11):822-830. Epub 2020 Aug 12. PMID: 32784298

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Pubmed Data : Genes Nutr. 2016 ;11:2. Epub 2016 Mar 17. PMID: 27482294

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin, Tetrahydrocurcumin

Diseases : Osteoarthritis, Postmenopausal Disorders

Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Tetrahydrocurcumin and Octahydrocurcumin possess superior anti-inflammatory effects in vivo.Dec 31, 2017

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2005;16(1):1-15. PMID: 16187483

Additional Keywords : Natural Substance Synergy

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Pubmed Data : Anticancer Agents Med Chem. 2019 Jan 16. Epub 2019 Jan 16. PMID: 30652650

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Pubmed Data : PLoS One. 2025 ;20(2):e0313585. Epub 2025 Feb 6. PMID: 39913473

Article Published Date : Dec 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Tetrahydrocurcumin

Diseases : Ovarian Cancer

Pharmacological Actions : Chemotherapeutic

[+]

Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin.Dec 31, 2022

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Pubmed Data : Mol Cell Biochem. 2007 Feb;296(1-2):85-95. Epub 2006 Sep 8. PMID: 16960658

Article Published Date : Feb 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Tetrahydrocurcumin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant

Pharmacological Actions : Antineoplastic Agents

[+]

Tetrahydrocurcumin outperforms curcumin in preventing oxidative stress-induced dysfunction in tert-butyl hydroperoxide-stimulated cardiac fibroblasts.Jun 20, 2025

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Pubmed Data : Food Funct. 2024 Jul 1 ;15(13):6798-6824. Epub 2024 Jul 1. PMID: 38836693

Article Published Date : Jun 30, 2024

Study Type : Review

Additional Links

Substances : Tetrahydrocurcumin

Diseases : Cancers: All, Inflammation, Metabolic Diseases, Neurological Conditions

Pharmacological Actions : Anti-Inflammatory Agents

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View the Evidence: 109 Abstracts with Tetrahydrocurcumin Research

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Short-term intravenous dosing of liposomal curcumin appears to be safe up to a dose of 120 mg/m2.Dec 31, 2014

Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis.Dec 31, 2024

Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer.Nov 04, 2024

A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.Aug 01, 2010

Administration of tetrahydrocurcumin exhibited significant reversal of arsenic induced toxicity in hepatic tissue.Jun 24, 2015

Antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase.Apr 03, 2020

Attenuation by tetrahydrocurcumin of adiposity and hepatic steatosis in mice with high-fat-diet-induced obesity.Nov 15, 2018

Both curcumin and its metabolite tetrahydrocurcumin exert neuroprotection against chemically-induced neurotoxicity.Apr 01, 2008

Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro.Nov 14, 2021

Cisplatin-induced LLC-PK1 renal cell damage was significantly reduced by tetrahydrocurcumin treatment. Feb 28, 2015

Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.Jun 30, 2016

Comparative inhibitory efficacy on the iNOS/NO system of curcumin- and tetrahydrocurcumin-self-microemulsifying liquid formulation in chronic gastric ulcer model.Aug 05, 2020

Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.Aug 01, 2001

Curcumin inhibit tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.Apr 01, 1998

Curcumin was shown to have positive effects on lifespan extension in animal studies. Dec 31, 2012

Curcuminoids inhibit chemically-induced tumor promotion.Oct 01, 1995

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

Explore the multitarget mechanism of tetrahydrocurcumin preventing on UV-induced photoaging mouse skin.Jul 31, 2022

Fucoxanthin, lutein and tetrahydrocurcumin may have chemopreventive effects against colon carcinogenesis.Jan 01, 1998

Nutritional antioxidants such as green tea polyphenols and tetrahydrocurcumin may beneficially modify the life span of animals.Oct 01, 2007

Short term effect of tetrahydrocurcumin on adipose angiogenesis in very high-fat diet-induced obesity mouse model.Dec 31, 2022

Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus.Aug 31, 2023

Supplementation with tetrahydrocurcumin enhances the therapeutic effects of dexamethasone in a murine model of allergic asthma.Dec 31, 2019

Suppression of GRASP65 phosphorylation by tetrahydrocurcumin protects against cerebral ischemia/reperfusion injury.Oct 31, 2016

Tetrahydrocurcumin (THC) enhanced the clearance of Cryptococcus deneoformans during infection.May 31, 2023

Tetrahydrocurcumin add-On therapy to losartan in a rat model of diabetic nephropathy.Mar 31, 2023

Tetrahydrocurcumin alleviates di-(2-ethylhexyl) phthalate-induced adipose tissue dysfunction and testicular toxicity in adult mice.Dec 19, 2024

Tetrahydrocurcumin alleviates metabolic dysfunction-associated steatohepatitis.Jan 21, 2025

Tetrahydrocurcumin ameliorates diabetes profiles of db/db mice.Jun 09, 2020

Tetrahydrocurcumin ameliorates diabetic cardiomyopathy.Dec 31, 2018

Tetrahydrocurcumin ameliorates hepatic steatosis by restoring hepatocytes lipophagy through mTORC1-TFEB pathway in nonalcoholic steatohepatitis.Aug 31, 2024

Tetrahydrocurcumin ameliorates kidney injury and high systolic blood pressure.Jul 31, 2021

Tetrahydrocurcumin ameliorates postinfarction cardiac dysfunction and remodeling.Nov 30, 2023

Tetrahydrocurcumin ameliorates skin inflammation by modulating autophagy in high-fat diet-induced obesity.Dec 31, 2020

Tetrahydrocurcumin and curcumin are effective for treating postmenopausal and osteoarthritis symptoms in ovariectomized rats.Dec 31, 2015

Tetrahydrocurcumin and Octahydrocurcumin possess superior anti-inflammatory effects in vivo.Dec 31, 2017

Tetrahydrocurcumin and rutin have cardioprotective properties in a rat model of myocardial infarctionFeb 01, 2009

Tetrahydrocurcumin can be a promising candidate for the prevention of chemotherapy induced peripheral neuropathy.Jun 19, 2015

Tetrahydrocurcumin demonstrated an inhibitory effect against tumor angiogenesis in CaSki-implanted nude mice model.Dec 31, 2014

Tetrahydrocurcumin displays antihyperlipidaemic effect in addition to its antidiabetic effect in type 2 diabetic rats.Aug 01, 2006

Tetrahydrocurcumin effectively subdues the cadmium-induced toxicity and controls the free radical-induced liver damage in rats.Feb 23, 2017

Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke.Dec 31, 2018

Tetrahydrocurcumin has a protective effect on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.Oct 01, 2007

Tetrahydrocurcumin has antioxidant and anti-diabetic activity in streptozotocin-nicotinamide induced diabetic rats.Sep 27, 2006

Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction.Aug 31, 2022

Tetrahydrocurcumin increases the number of total cellular insulin binding sites resulting in a significant increase in plasma insulin. Mar 01, 2008

Tetrahydrocurcumin inhibited tumor growth and tumor progression in CaSki-implanted female nude mice.Dec 31, 2015

Tetrahydrocurcumin lipid nanoparticle based gel promotes penetration into deeper skin layers and alleviates atopic dermatitis.Feb 13, 2022

Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation.Jun 22, 2020

Tetrahydrocurcumin normalizes blood glucose and causes a marked improvement of altered carbohydrate metabolic enzymes in diabetic animals.Jan 01, 2005

Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats.Jun 01, 2007

Tetrahydrocurcumin protected against nerve injury after traumatic brain injury.Aug 31, 2024

Tetrahydrocurcumin protects against oxidative stress in cholesterol-fed rabbits.Jan 01, 2002

Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response.Oct 31, 2019

Tetrahydrocurcumin protectsagainst erythromycin estolate-induced lipid peroxidation in rats.Jan 01, 2005

Tetrahydrocurcumin provides neuroprotection in experimental traumatic brain injury.Dec 31, 2016

The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin.Nov 14, 2023

These findings provided additional important information on the effects of THC on diet induced-metabolic dysfunctions. Jun 19, 2015

These results demonstrated a potential mechanism underlying the beneficial effects of Tetrahydrocurcumin against hyperglycemia.Dec 18, 2021

These results suggest beneficial effects of Tetrahydrocurcumin and L1 on iron-induced oxidative stress, hypertension, and vascular dysfunction.Nov 30, 2016

This study indicates that tetrahydrocurcumin protects neurons from traumatic brain injury-induced apoptotic neuronal death.Oct 31, 2016

Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation.Sep 30, 2018

A combination of doxorubicin and tetrahydrocurcumin nanoparticles is a promising strategy for synergistic and sensitizing chemoradiotherapy of glioma.Dec 18, 2019

Anti-inflammatory effect of curcuminoids and their analogs in hyperosmotic human corneal limbus epithelial cells.Apr 22, 2024

Antibacterial and antiviral properties of tetrahydrocurcumin-based formulations.Oct 25, 2022

Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer.Aug 03, 2025

Comparation of anti-inflammatory and antioxidantactivities of curcumin, tetrahydrocurcuminand octahydrocurcuminin LPS-stimulated RAW264.7 macrophages.Dec 31, 2019

Curcumin and its metabolites could inhibit type A influenza virus infection.Oct 31, 2013

Curcumin and tetrahydrocurcumin can alleviate vascular dysfunction and high blood pressure caused by cadmium toxicity.Dec 31, 2015

Curcumin and tetrahydrocurcumin induce cell death in Ara-C-resistant acute myeloid leukemia.Mar 31, 2019

Curcumin metabolite tetrahydrocurcumin in the treatment of eye diseases. Dec 27, 2020

Tetrahydrocurcumin

View the Evidence:
109 Abstracts with Tetrahydrocurcumin Research