Theaflavins

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44 Diseases Researched for Theaflavins
NameACCKFocus
Ovarian Cancer55Locked
Parkinson's Disease35Locked
Brain Inflammation 24Locked
Colon Cancer33Locked
Liver Cancer23Locked
Oxidative Stress23Locked
Anxiety12Locked
Cancers: Drug Resistant22Locked
Cardiovascular Diseases12Locked
Cerebral Hemorrhage12Locked
Cervical Cancer22Locked
Coronavirus Infection22Locked
Depression12Locked
Herpes Simplex Virus Type 122Locked
Ischemia12Locked
Kidney Damage12Locked
Liver Cancer: Prevention12Locked
Neurodegenerative Diseases12Locked
Osteoarthritis12Locked
Osteoporosis12Locked
Periodontal Diseases22Locked
Periodontitis12Locked
Tongue Cancer12Locked
Alcohol Toxicity 11Locked
Cancers: All11Locked
Cancers: Multi-Drug Resistant11Locked
Cartilage Diseases11Locked
Clostridium Infections11Locked
Copper Toxicity11Locked
Coronaviridae Infections11Locked
Coronavirus Disease11Locked
Diabetes Mellitus: Type 211Locked
HIV Infections11Locked
Hepatitis C11Locked
Herpes Simplex Virus Type 211Locked
Human Papillomavirus (HPV)11Locked
Insulin Disorders11Locked
Insulin Resistance11Locked
Lung Cancer11Locked
Obesity11Locked
Porphyromonas gingivalis11Locked
Severe Acute Respiratory Syndrome11Locked
Simian virus 40 (SV40)11Locked
Skin Cancer11Locked
44 Pharmacological Actions Researched for Theaflavins
NameACCKFocus
Anti-Inflammatory Agents710Locked
Antioxidants69Locked
Apoptotic99Locked
Antiviral Agents77Locked
Antiproliferative 55Locked
Chemopreventive35Locked
Neuroprotective Agents35Locked
Anticarcinogenic Agents24Locked
Chemotherapeutic44Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor34Locked
Nrf2 activation24Locked
Osteoprotective 24Locked
Regenerative24Locked
Anti-Apoptotic23Locked
Chemosensitizer33Locked
Interleukin-1 beta downregulation23Locked
Interleukin-6 Downregulation23Locked
Interleukin-8 downregulation23Locked
NF-kappaB Inhibitor23Locked
Wnt/β-catenin signaling pathway modulation23Locked
Anti-Anxiety Agents12Locked
Anti-Bacterial Agents22Locked
Anti-metastatic22Locked
Antidepressive Agents12Locked
Cardioprotective12Locked
Cell cycle arrest22Locked
Cyclooxygenase 2 Inhibitors22Locked
Heme oxygenase-1 up-regulation12Locked
Interleukin-18 down-regulation12Locked
Renoprotective12Locked
Vascular Endothelial Growth Factor Inhibitors22Locked
Alpha-glucosidase inhibitor 11Locked
Anti-Angiogenic11Locked
Anti-Infective Agents11Locked
Gastroprotective11Locked
Hypoglycemic Agents11Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor11Locked
Insulin Sensitizers11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Matrix metalloproteinase-3 (MMP-3) inhibitor11Locked
Matrix metalloproteinase-8 (MMP-8) inhibitor11Locked
Metal Chelation: Copper11Locked
Neuritogenic11Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor11Locked

View the Evidence:
77 Abstracts with Theaflavins Research

[+]

Theaflavins have beneficial effects on oral bacteria for the prevention of periodontal disease.Oct 31, 2021

Pubmed Data : J Med Food. 2021 Nov ;24(11):1186-1190. Epub 2021 Oct 25. PMID: 34698557
Article Published Date : Oct 31, 2021
Study Type : Human Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Periodontal Diseases
Pharmacological Actions : Anti-Bacterial Agents
[+]

Tooth brushing using toothpaste containing theaflavins reduces the oral pathogenic bacteria in healthy adults.Feb 28, 2021

Pubmed Data : 3 Biotech. 2021 Mar ;11(3):150. Epub 2021 Mar 2. PMID: 33747700
Article Published Date : Feb 28, 2021
Study Type : Human Study
Additional Links
Substances : Theaflavins
Diseases : Steptococcus Mutans Infections
Pharmacological Actions : Antimicrobial
[+]

Theaflavin ameliorates streptococcus suis-induced infectionApr 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Apr 18 ;24(8). Epub 2023 Apr 18. PMID: 37108608
Article Published Date : Apr 17, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Streptococcus Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Theaflavin-3,3'-di-gallate represses prostate cancer.Apr 19, 2022

Pubmed Data : Food Funct. 2022 Apr 20 ;13(8):4421-4431. Epub 2022 Apr 20. PMID: 35302141
Article Published Date : Apr 19, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Prostate Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

Theaflavin-3,3'-digallate from black tea inhibits neointima formation.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:861319. Epub 2022 Jul 12. PMID: 35903325
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Atherosclerosis, Restenosis
[+]

A single dose of theaflavin rich fraction enhanced energy expenditure accompanied by an increase in expression of metabolic genes.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0137809. Epub 2015 Sep 16. PMID: 26375960
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
Additional Keywords : Risk Reduction
[+]

Anxiolytic effects of theaflavins via dopaminergic activation in the frontal cortex.May 31, 2019

Pubmed Data : Biosci Biotechnol Biochem. 2019 Jun ;83(6):1157-1162. Epub 2019 Feb 26. PMID: 30806570
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Anxiety
Pharmacological Actions : Anti-Anxiety Agents, Antioxidants
[+]

Black tea theaflavins could protect against liver and kidney damage.May 17, 2021

Pubmed Data : J Agric Food Chem. 2021 May 18. Epub 2021 May 18. PMID: 34003645
Article Published Date : May 17, 2021
Study Type : Animal Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Renoprotective
[+]

Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.Aug 20, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug 21. Epub 2015 Aug 21. PMID: 26386739
Article Published Date : Aug 20, 2015
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy.Feb 28, 2023

Pubmed Data : J Nat Med. 2023 Mar 1. Epub 2023 Mar 1. PMID: 36854953
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Food Allergies
Pharmacological Actions : Anti-Allergic Agents, Antioxidants
[+]

Tea polyphenols Epigallocatechin gallate and Theaflavin restrict tongue and liver carcinogenesis.May 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Jun 1 ;300:34-46. Epub 2016 Apr 4. PMID: 27058323
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Liver Cancer, Tongue Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 21 ;7:44815. Epub 2017 Mar 21. PMID: 28322293
Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Black Tea, EGCG (Epigallocatechin gallate), Green Tea, Polyphenols, Theaflavins
Diseases : Endometriosis, Periodontitis
Pharmacological Actions : Anti-Bacterial Agents, Gastrointestinal Agents
Additional Keywords : Plant Extracts
[+]

Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:1609-1619. Epub 2018 Jun 12. PMID: 29928110
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Brain Inflammation , Cerebral Hemorrhage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease.Aug 30, 2012

Pubmed Data : Neuroscience. 2012 Aug 30 ;218:257-67. Epub 2012 May 23. PMID: 22634505
Article Published Date : Aug 30, 2012
Study Type : Animal Study
Additional Links
Substances : Catechin , Theaflavins
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Theaflavin ameliorates renal ischemia/reperfusion injury.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Feb ;134:111097. Epub 2020 Dec 16. PMID: 33341051
Article Published Date : Jan 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Theaflavin can be used as a potential agent for cutaneous wound therapy.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Bioeng Biotechnol. 2022 ;10:830574. Epub 2022 Mar 2. PMID: 35309982
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Wound Healing
Pharmacological Actions : Cytoprotective
[+]

Theaflavin promotes mitochondrial abundance and glucose absorption in myotubes.Jul 27, 2021

Pubmed Data : J Agric Food Chem. 2021 Jul 28 ;69(29):8144-8159. Epub 2021 Jul 14. PMID: 34260232
Article Published Date : Jul 27, 2021
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2021 ;17(4):1050-1060. Epub 2021 Mar 2. PMID: 33867828
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Kidney Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Theaflavin protects chondrocytes against apoptosis and senescence.Jan 19, 2021

Pubmed Data : Food Funct. 2021 Jan 20. Epub 2021 Jan 20. PMID: 33471008
Article Published Date : Jan 19, 2021
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Osteoarthritis
Pharmacological Actions : Osteoprotective
[+]

Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease.Jan 18, 2012

Pubmed Data : Brain Res. 2012 Jan 18 ;1433:104-13. Epub 2011 Nov 13. PMID: 22138428
Article Published Date : Jan 18, 2012
Study Type : Animal Study
Additional Links
Substances : Black Tea, Black Tea Theaflavins, Catechin , Polyphenols, Tea, Theaflavins
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Theaflavin-3, 3'-digallate may have the potential to treat osteoporosis and bone diseases related to excessive osteoclastogenesis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:803. Epub 2020 Jun 29. PMID: 32694992
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Osteoporosis
Pharmacological Actions : Antioxidants, Nrf2 activation, Osteoprotective
[+]

Theaflavin-3,3'-digallate ameliorates learning and memory impairments.Mar 14, 2023

Pubmed Data : Physiol Behav. 2023 Mar 15 ;261:114077. Epub 2023 Jan 11. PMID: 36638877
Article Published Date : Mar 14, 2023
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Aging, Memory Disorders, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Theaflavin-3,3'-digallate might have the potential to be a more effective treatment of postmenopausal osteoporosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:648969. Epub 2021 Mar 23. PMID: 33833684
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Theaflavins decrease skeletal muscle wasting in disuse atrophy induced by hindlimb suspension.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2021 May ;68(3):228-234. Epub 2020 Nov 14. PMID: 34025025
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Muscle Atrophy
[+]

Theaflavins have therapeutic potential in the treatment of periodontal disease.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Periodontal Res. 2018 Dec ;53(6):1009-1019. Epub 2018 Aug 30. PMID: 30159985
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Theaflavins in black tea mitigate aging-associated cognitive dysfunction.Feb 07, 2023

Pubmed Data : J Agric Food Chem. 2023 Feb 8 ;71(5):2356-2369. Epub 2023 Jan 31. PMID: 36718846
Article Published Date : Feb 07, 2023
Study Type : Animal Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Aging: Brain , Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Neuroprotective Agents
Additional Keywords : Gut-brain Axis
[+]

These results suggest that theaflavins can suppress neural inflammation and prevent the symptoms of inflammation-related brain disorders.Jan 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Jan 28 ;24(3). Epub 2019 Jan 28. PMID: 30696093
Article Published Date : Jan 27, 2019
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
[+]

Theaflavins suppress the growth and metastasis of human hepatocellular carcinoma.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2016 ;9:4265-75. Epub 2016 Jul 14. PMID: 27478384
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Advances on natural polyphenols as anticancer agents for skin cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2020 01 ;151:104584. Epub 2019 Dec 3. PMID: 31809853
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Punicalagin, Quercetin, Resveratrol, Theaflavins
Diseases : Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic, Chemopreventive
[+]

All four theaflavin derivatives tested reduced the viability of ovarian cancer cells.Jan 31, 2016

Pubmed Data : Anticancer Res. 2016 Feb ;36(2):643-51. PMID: 26851019
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Vascular Endothelial Growth Factor Inhibitors
[+]

Anti-cancer properties of theaflavins. Feb 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Feb 13 ;26(4). Epub 2021 Feb 13. PMID: 33668434
Article Published Date : Feb 12, 2021
Study Type : Review
Additional Links
Substances : Theaflavins
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Anticancer effects and molecular target of theaflavins from black tea fermentation in vitro and in vivo.Dec 21, 2021

Pubmed Data : J Agric Food Chem. 2021 Dec 22 ;69(50):15052-15065. Epub 2021 Dec 8. PMID: 34878780
Article Published Date : Dec 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Cancers: All
Pharmacological Actions : Antioxidants, Antiproliferative , Cell cycle arrest
[+]

Black tea extract and theaflavins exerts antibacterial activity against major periodontopathogens.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0143158. Epub 2015 Nov 18. PMID: 26581041
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Periodontal Diseases
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-8 downregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Black tea extract has the potential to be developed as a safe, therapeutic antiviral agent to prevent the spread of HSV-1.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2013 ;13:139. Epub 2013 Jun 18. PMID: 23777309
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Anti-Infective Agents, Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Black tea polyphenol theaflavin as promising antioxidant and potential copper chelator.Feb 21, 2020

Pubmed Data : J Sci Food Agric. 2020 Feb 22. Epub 2020 Feb 22. PMID: 32086808
Article Published Date : Feb 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Copper Toxicity
Pharmacological Actions : Metal Chelation: Copper
[+]

Black tea theaflavins represent promising multifunctional therapeutic agents for prevention and treatment of periodontal disease.Aug 22, 2016

Pubmed Data : J Periodontal Res. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27549582
Article Published Date : Aug 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Periodontal Diseases, Porphyromonas gingivalis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-8 (MMP-8) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Computational investigation of ginkgetin and theaflavin as potential inhibitors of heat shock protein 90.Dec 31, 2021

Pubmed Data : J Biomol Struct Dyn. 2022 ;40(24):13675-13681. Epub 2021 Oct 25. PMID: 34693877
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba, Theaflavins
Diseases : Cancers: All
Pharmacological Actions : Heat Shock Protein Down-Regulation
[+]

EGCG and theaflavins chemosensitize the cervical cancer cells to cisplatin induced growth inhibition and apoptosis.Jul 18, 2013

Pubmed Data : Life Sci. 2013 Jul 19 ;93(1):7-16. Epub 2013 Feb 9. PMID: 23399702
Article Published Date : Jul 18, 2013
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Flavonoids as new regulators of mitochondrial potassium channels: contribution to cardioprotection.Dec 11, 2022

Pubmed Data : J Pharm Pharmacol. 2022 Dec 12. Epub 2022 Dec 12. PMID: 36508341
Article Published Date : Dec 11, 2022
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Flavonoids, Genistein, Naringenin , Puerarin, Quercetin, Theaflavins
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective
[+]

Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Qatar Med J. 2021 ;2021(1):12. Epub 2021 Mar 12. PMID: 34604010
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Glycyrrhizin, Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

In vitro virucidal activity of the theaflavin-concentrated tea extract TY-1 against influenza A virus.Sep 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nat Med. 2021 Sep 22. Epub 2021 Sep 22. PMID: 34550554
Article Published Date : Sep 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
[+]

Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′-digallate.Dec 31, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2005 06 ;2(2):209-215. Epub 2005 Apr 7. PMID: 15937562
Article Published Date : Dec 31, 2004
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Coronaviridae Infections, Severe Acute Respiratory Syndrome
Pharmacological Actions : Antiviral Agents
[+]

Inhibitory effect of black tea (Camellia sinensis) theaflavins and thearubigins against HCT 116 colon cancer cells and HT 460 lung cancer cells.Apr 30, 2019

Pubmed Data : J Food Biochem. 2019 May ;43(5):e12822. Epub 2019 Mar 4. PMID: 31353529
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Colon Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Inhibitory effect of black tea pigments, theaflavin 3/3'-gallate against cisplatin-resistant ovarian cancer cells.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2017 Nov ;51(5):1508-1520. Epub 2017 Oct 3. PMID: 29048667
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Mechanism for antibacterial action of epigallocatechin gallate and theaflavin-3,3'-digallate on Clostridium perfringens.Jan 31, 2019

Pubmed Data : J Appl Microbiol. 2019 Feb ;126(2):633-640. Epub 2018 Nov 23. PMID: 30353941
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Clostridium Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Mechanisms of theaflavins against gout and strategies for improving the bioavailability.May 31, 2023

Pubmed Data : Phytomedicine. 2023 Jun ;114:154782. Epub 2023 Mar 23. PMID: 36990009
Article Published Date : May 31, 2023
Study Type : Review
Additional Links
Substances : Theaflavins
Diseases : Gout
Pharmacological Actions : Matrix metalloproteinase-14 (MMP-14) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Mechanistic insights into the inhibitory effect of theaflavins on virulence factors production in Streptococcus mutans.Jul 08, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : AMB Express. 2021 Jul 9 ;11(1):102. Epub 2021 Jul 9. PMID: 34244882
Article Published Date : Jul 08, 2021
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Steptococcus Mutans Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Gene Expression Regulation
[+]

Natural polyphenols have potential in the prevention of sexually transmitted viral infections.Nov 03, 2015

Pubmed Data : Drug Discov Today. 2015 Nov 4. Epub 2015 Nov 4. PMID: 26546859
Article Published Date : Nov 03, 2015
Study Type : Review
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Genistein, Polyphenols, Resveratrol, Theaflavins
Diseases : Herpes Simplex Virus Type 2, HIV Infections, Human Papillomavirus (HPV)
Pharmacological Actions : Antiviral Agents
[+]

Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2.Jul 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomol Struct Dyn. 2020 Jul 28:1-16. Epub 2020 Jul 28. PMID: 32720577
Article Published Date : Jul 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Hesperidin, Myricetin, Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Pre-treated theaflavin-3,3'-digallate has a higher inhibitory effect on the HCT116 cell line.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2017 ;61(1):1400340. Epub 2017 Nov 15. PMID: 29200992
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Severe acute respiratory syndrome coronavirus-2 inactivation activity of the polyphenol-rich tea leaf extract.Aug 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Aug 8 ;26(16). Epub 2021 Aug 8. PMID: 34443390
Article Published Date : Aug 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Catechin , Green Tea, Polyphenols, Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Structure-activity relationship analysis on antioxidant and anticancer actions of theaflavins on human colon cancer cells.Nov 25, 2018

Pubmed Data : J Agric Food Chem. 2018 Nov 26. Epub 2018 Nov 26. PMID: 30474978
Article Published Date : Nov 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Colon Cancer
Pharmacological Actions : Antioxidants, Chemotherapeutic
[+]

Synergistic effect of black tea polyphenol, theaflavin-3,3'-digallate with cisplatin against cisplatin resistant human ovarian cancer cells.Jun 30, 2018

Pubmed Data : J Funct Foods. 2018 Jul ;46:1-11. Epub 2018 Apr 26. PMID: 30364631
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Tea bioactive modulate innate immunity: in perception to COVID-19 pandemic.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2020 ;11:590716. Epub 2020 Oct 28. PMID: 33193427
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Black Tea, EGCG (Epigallocatechin gallate), Green Tea, Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunomodulatory
Additional Keywords : Plant Extracts
[+]

The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against α-glucosidase by increasing the polyphenol-enzyme binding interactions.Dec 08, 2020

Pubmed Data : Food Funct. 2020 Dec 9. Epub 2020 Dec 9. PMID: 33295908
Article Published Date : Dec 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Polyphenols, Theaflavins
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Alpha-glucosidase inhibitor , Hypoglycemic Agents
[+]

The prevention role of theaflavin-3,3'-digallate in angiotensin II Induced pathological cardiac hypertrophy.Mar 25, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Mar 26 ;14(7). Epub 2022 Mar 26. PMID: 35406003
Article Published Date : Mar 25, 2022
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Cardiomegaly, Heart Failure
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Theaflavin 3-gallate inhibits the main protease (M pro) of SARS-CoV-2 and reduces its count in vitro.Jul 29, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Jul 30 ;12(1):13146. Epub 2022 Jul 30. PMID: 35908093
Article Published Date : Jul 29, 2022
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Theaflavin alleviates oxidative injury and atherosclerosis progress.Mar 22, 2021

Pubmed Data : Phytother Res. 2021 Mar 23. Epub 2021 Mar 23. PMID: 33755271
Article Published Date : Mar 22, 2021
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Atherosclerosis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, MicroRNA modulator, Nrf2 activation
[+]

Theaflavin and epigallocatechin-3-gallate synergistically induce apoptosis in HeLa cells.Nov 01, 2018

Pubmed Data : J Cell Biochem. 2018 Nov 2. Epub 2018 Nov 2. PMID: 30390323
Article Published Date : Nov 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Theaflavin binds to a druggable pocket of TMEM16A channel and inhibits lung adenocarcinoma cell Viability.Jul 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2021 Jul 27:101016. Epub 2021 Jul 27. PMID: 34329684
Article Published Date : Jul 26, 2021
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative
[+]

Theaflavin digallate has potential to be a promising natural and affordable remedy against herpes simplex viral infections.May 31, 2015

Pubmed Data : Antiviral Res. 2015 Jun ;118:56-67. Epub 2015 Mar 27. PMID: 25818500
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Antiviral Agents
Additional Keywords : Dose Response
[+]

Theaflavin exhibited anti-proliferative, pro-apoptotic, anti-migrative, and tumor-inhibitory effects on melanoma cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2021 ;14:1291-1304. Epub 2021 Feb 25. PMID: 33658796
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Melanoma
Pharmacological Actions : Anti-Apoptotic, Anti-metastatic, Antiproliferative
[+]

Theaflavin promoted apoptosis in nasopharyngeal carcinoma.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2022 Jan ;25(1):68-74. PMID: 35656444
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

Theaflavin-3'-O-gallate a black-tea constituent blocked SARS CoV-2 RNA dependant RNA polymerase active-siteSep 12, 2021

Pubmed Data : Drug Res (Stuttg). 2021 Sep 13. Epub 2021 Sep 13. PMID: 34517419
Article Published Date : Sep 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiviral Agents
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Theaflavin-3, 3'-digallate might serve as a potential anti-angiogenic agent for cancer treatment.Nov 19, 2015

Pubmed Data : Int J Oncol. 2015 Nov 20. Epub 2015 Nov 20. PMID: 26648098
Article Published Date : Nov 19, 2015
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Polyphenols, Theaflavins
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-Angiogenic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Theaflavin-3,3'-digallate ameliorates collagen-induced arthritis.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm Res. 2023 ;16:109-126. Epub 2023 Jan 10. PMID: 36647388
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Theaflavin-3,3'-digallate might be used as an adjuvant to potentiate the inhibitory effect of cisplatin against advanced ovarian cancer.Jan 01, 2018

Pubmed Data : Int J Mol Sci. 2018 Jan 2 ;19(1). Epub 2018 Jan 2. PMID: 29301278
Article Published Date : Jan 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Ovarian Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Theaflavins are promising functional food ingredients and medicines for improving insulin resistance-related disorders.Dec 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Dec 19 ;23(12). Epub 2018 Dec 19. PMID: 30572687
Article Published Date : Dec 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Insulin Disorders, Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Oct ;18(4):3791-3799. Epub 2018 Aug 3. PMID: 30106096
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Alcohol Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Gastroprotective
[+]

Theaflavins from black tea exhibit antiviral activity against bovine rotavirus and bovine coronavirus infections.Oct 01, 1998

Pubmed Data : Vet Microbiol. 1998 Oct ;63(2-4):147-57. PMID: 9850995
Article Published Date : Oct 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Black Tea Theaflavins, Catechin , Tea, Theaflavins
Diseases : Coronavirus Disease, Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Theaflavins from black tea selectively inhibit SV40-transformed cancer cells.Nov 15, 2000

Pubmed Data : Cancer Res. 2000 Nov 15;60(22):6465-71. PMID: 11103814
Article Published Date : Nov 15, 2000
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Catechin , Theaflavins
Diseases : Cancers: All, Simian virus 40 (SV40)
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Selective Cytotoxicity
[+]

Theaflavins inhibit entry of hepatitis C virus in cell culture.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0198226. Epub 2018 Nov 28. PMID: 30485282
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
[+]

Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Feb ;19(2):821-830. Epub 2018 Dec 12. PMID: 30569095
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Cartilage Diseases
[+]

These data provide a putative mechanism to explain the anti-obesity effects of tea. Jan 31, 2017

Pubmed Data : Food Chem. 2017 Feb 1 ;216:296-300. Epub 2016 Aug 18. PMID: 27596423
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

These results suggest potential usefulness of tea in prevention of person-to-person transmission of the novel coronavirus.Jun 10, 2021

Pubmed Data : Molecules. 2021 Jun 11 ;26(12). Epub 2021 Jun 11. PMID: 34208050
Article Published Date : Jun 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Catechin , Green Tea, Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

These studied flavonoids significantly enhances doxorubicin-mediated cell death.Nov 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2018 Nov 26 ;18(1):1168. Epub 2018 Nov 26. PMID: 30477461
Article Published Date : Nov 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Flavonoids, Quercetin, Rutin, Theaflavins
Diseases : Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Wnt/β-catenin signaling pathway modulation
[+]

This review collates the current knowledge of tea polyphenols and puts into perspective their potential to be considered as nutraceuticals that target various pathologies in PD.Dec 31, 2014

Pubmed Data : Adv Exp Med Biol. 2015;863:117-137. PMID: 26092629
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Black Tea, EGCG (Epigallocatechin gallate), Green Tea, Polyphenols, Tea, Theaflavins
Diseases : Parkinson's Disease
Pharmacological Actions : Neuritogenic, Neuroprotective Agents

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