Theanine

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62 Diseases Researched for Theanine
NameACCKFocus
Stress423Locked
Immune Disorders: Low Immune Function322Locked
Athletic Performance220Locked
Athletic Performance: Recovery 220Locked
Anxiety313Locked
Cognitive Decline/Dysfunction313Locked
Attention Deficit Disorder with Hyperactivity110Locked
Brain Wave Dysfunction: Low Alpha Band Activity110Locked
Cortisol: High110Locked
Depressive Disorder110Locked
Immune Dysregulation: TH1/TH2 imbalance110Locked
Influenza A110Locked
Influenza in Swine110Locked
Lymphopenia110Locked
Neutrophils: Elevated110Locked
Swine Flu Associated Virus110Locked
Alzheimer's Disease36Locked
Oxidative Stress35Locked
Depression24Locked
Brain Ischemia23Locked
Inflammation23Locked
Liver Cancer23Locked
Liver Damage23Locked
Aluminum Toxicity 12Locked
Anxiety Disorders12Locked
Appetite Disorders12Locked
Asthma12Locked
Brain Inflammation 12Locked
Cerebral Ischemia12Locked
Cervical Cancer12Locked
Chemotherapy-Induced Toxicity: Doxorubicin12Locked
Chemotherapy-Induced Toxicity: Oxaliplatin12Locked
Chemotherapy-Induced Toxicity: Peripheral Neuropathy12Locked
Corneal Neovascularization12Locked
Excitotoxicity 12Locked
Hyperinsulinism12Locked
Inflammatory Bowel Diseases12Locked
Ischemia12Locked
Kidney Damage12Locked
Lipid Peroxidation12Locked
Memory Loss12Locked
Mood Disorders12Locked
Neurodegenerative Diseases12Locked
Osteoarthritis: Knee12Locked
Parkinson's Disease22Locked
Postnatal Care: Breastfeeding12Locked
Radiation12Locked
Retinopathy of Prematurity12Locked
Retrolental Fibroplasia12Locked
Sepsis12Locked
Sleep Disorders12Locked
Spinal Cord Injuries12Locked
Advanced Glycation End products (AGE)11Locked
Aging: Liver11Locked
Cancer Metastasis11Locked
Cancers: All11Locked
Hepatoma11Locked
Leukemia11Locked
Memory Disorders11Locked
Non-Small-Cell Lung Carcinoma11Locked
Ovarian Cancer11Locked
Pesticide Toxicity 11Locked
30 Pharmacological Actions Researched for Theanine
NameACCKFocus
Neuroprotective Agents1244Locked
Anti-Inflammatory Agents814Locked
Antidepressive Agents314Locked
Anti-Anxiety Agents313Locked
Immunomodulatory211Locked
Anti-Bacterial Agents110Locked
Interleukin-10 downregulation110Locked
Antioxidants58Locked
Anti-metastatic46Locked
Anti-Apoptotic35Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor35Locked
Antiproliferative 24Locked
Chemoprotective Agents24Locked
NF-kappaB Inhibitor24Locked
Apoptotic23Locked
Interleukin-1 beta downregulation23Locked
Interleukin-6 Downregulation23Locked
Anti-Allergic Agents12Locked
Anxiolytic12Locked
Gastrointestinal Agents12Locked
Gastroprotective12Locked
Hepatoprotective12Locked
Malondialdehyde Down-regulation12Locked
Neuritogenic12Locked
Nitric Oxide Inhibitor12Locked
Radioprotective12Locked
Renoprotective12Locked
Anti-Glycation Agents11Locked
Antineoplastic Agents11Locked
Enzyme Inhibitors11Locked

View the Evidence:
76 Abstracts with Theanine Research

[+]

A combination of Magnolia, Epimedium, Theanine, Beta Sitosterol, Phosphatidylcholine reduces serum cortisol responses to physical stress. Aug 01, 2006

Pubmed Data : Arch Dermatol. 2006 Aug;142(8):985-90. PMID: 15877297
Article Published Date : Aug 01, 2006
Study Type : Human Study
Additional Links
Substances : Beta Sitosterol, Epimedium, Magnolia, Phosphatidylcholine, Theanine
Diseases : Cortisol: High
[+]

Among healthcare workers for the elderly, taking green tea catechins and theanine may be effective prophylaxis for influenza infection.Jan 01, 2011

Pubmed Data : BMC Complement Altern Med. 2011 ;11:15. Epub 2011 Feb 21. PMID: 21338496
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Catechin , Green Tea, Tea, Theanine
Diseases : Influenza A
Additional Keywords : Health Care Workers, Plant Extracts
[+]

Cystine (a dipeptide of cysteine) and theanine supplementation restores high-Intensity resistance exercise-induced atenuation of natural killer cell activity in well-trained men.Feb 09, 2010

Pubmed Data : J Strength Cond Res. 2010 Feb 9. Epub 2010 Feb 9. PMID: 20145562
Article Published Date : Feb 09, 2010
Study Type : Human Study
Additional Links
Substances : Cysteine (see N-Acetylcysteine), Theanine
Diseases : Athletic Performance: Recovery , Immune Disorders: Low Immune Function
[+]

Effects of L-theanine-caffeine combination on sustained attention and inhibitory control among children with ADHD.Jan 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 08 4 ;10(1):13072. Epub 2020 Aug 4. PMID: 32753637
Article Published Date : Jan 03, 2020
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Attention Deficit Disorder with Hyperactivity
Pharmacological Actions : Neuroprotective Agents
[+]

L-cystine and l-theanine may contribute to enhancing the immune response against the H1N1 virus. Dec 01, 2008

Pubmed Data : Geriatr Gerontol Int. 2008 Dec;8(4):243-50. PMID: 19149835
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Cysteine (see N-Acetylcysteine), Theanine
Diseases : Influenza in Swine, Swine Flu Associated Virus
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

l-theanine adjunct to sertraline for major depressive disorder.Jul 14, 2023

Pubmed Data : J Affect Disord. 2023 Jul 15 ;333:38-43. Epub 2023 Apr 19. PMID: 37084960
Article Published Date : Jul 14, 2023
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

l-theanine has multiple beneficial effects on depressive symptoms, anxiety, sleep disturbance and cognitive impairments in patients with MDD.Jul 10, 2016

Pubmed Data : Acta Neuropsychiatr. 2016 Jul 11:1-8. Epub 2016 Jul 11. PMID: 27396868
Article Published Date : Jul 10, 2016
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Anxiety, Depressive Disorder
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

L-theanine has the potential to promote mental health in the general population with stress-related ailments and cognitive impairments.Oct 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Oct 3 ;11(10). Epub 2019 Oct 3. PMID: 31623400
Article Published Date : Oct 02, 2019
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Stress
Pharmacological Actions : Neuroprotective Agents
[+]

L-theanine improves neurophysiological measures of attention in a dose-dependent manner.Aug 10, 2020

Pubmed Data : Nutr Neurosci. 2020 Aug 11:1-11. Epub 2020 Aug 11. PMID: 32777998
Article Published Date : Aug 10, 2020
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Dose Response
[+]

l-theanine may contribute to improving attention, thus enhancing working memory and executive functions.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2021 Apr ;24(4):333-341. Epub 2021 Mar 22. PMID: 33751906
Article Published Date : Mar 31, 2021
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

L-Theanine reduces psychological and physiological stress responses.Jan 01, 2007

Pubmed Data : Biol Psychol. 2007 Jan;74(1):39-45. Epub 2006 Aug 22. PMID: 16930802
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Stress
[+]

L-theanine significantly increases activity in the alpha frequency band resulting in increased relaxation of the mind without drowsiness. Jan 01, 2008

Pubmed Data : Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PMID: 18296328
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Brain Wave Dysfunction: Low Alpha Band Activity
[+]

Supplementation with L-theanine seems to exert a beneficial effect on a disrupted Th1/Th2 balance in elite athletes.Feb 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Soc Sports Nutr. 2019 Feb 15 ;16(1):7. Epub 2019 Feb 15. PMID: 30770758
Article Published Date : Feb 14, 2019
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Athletic Performance, Immune Dysregulation: TH1/TH2 imbalance
Therapeutic Actions : Exercise
Pharmacological Actions : Immunomodulatory, Interleukin-10 downregulation
[+]

The theanine content of tea may be responsible for it significantly increasing immune function in users, relative to coffee consumption.May 13, 2003

Pubmed Data : Proc Natl Acad Sci U S A. 2003 May 13;100(10):6009-14. Epub 2003 Apr 28. PMID: 12719524
Article Published Date : May 13, 2003
Study Type : Human Study
Additional Links
Substances : Black Tea, Coffee, Green Tea, Theanine
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Anti-Bacterial Agents
[+]

Theanine/cysteine intake suppresses exercise-induced neutrophilia and lymphopenia in athletes.Jan 01, 2010

Pubmed Data : J Int Soc Sports Nutr. 2010;7(1):23. Epub 2010 Jun 4. PMID: 20525371
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Cysteine (see N-Acetylcysteine), Theanine
Diseases : Athletic Performance, Athletic Performance: Recovery , Lymphopenia, Neutrophils: Elevated
[+]

Use of nutritional supplements based on L-theanine and vitamin B6 in children with Tourette syndrome, with anxiety disorders.Feb 17, 2022

Pubmed Data : Nutrients. 2022 Feb 18 ;14(4). Epub 2022 Feb 18. PMID: 35215501
Article Published Date : Feb 17, 2022
Study Type : Human Study
Additional Links
Substances : Theanine, Vitamin B-6
Diseases : Anxiety, Tourette Syndrome
Pharmacological Actions : Anti-Anxiety Agents
[+]

L-theanine prevents progression of nonalcoholic hepatic steatosis.Apr 14, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2022 Apr 15 ;19(1):29. Epub 2022 Apr 15. PMID: 35428314
Article Published Date : Apr 14, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theanine
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Protective effects of L-theanine on rats with dextran sulfate sodium-induced inflammatory bowel disease.Jul 27, 2020

Pubmed Data : Arch Pharm Res. 2020 Jul 28. Epub 2020 Jul 28. PMID: 32720164
Article Published Date : Jul 27, 2020
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective
[+]

Ameliorative effects of L-theanine on dextran sulfate sodium induced colitis.Jan 10, 2020

Pubmed Data : Food Res Int. 2020 11 ;137:109409. Epub 2020 Jun 9. PMID: 33233096
Article Published Date : Jan 10, 2020
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective
[+]

Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Aging Neurosci. 2022 ;14:964077. Epub 2022 Sep 16. PMID: 36185487
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Krill, Nobiletin , Theanine
Diseases : Aging: Brain , Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

Cystine and theanine improve survival after gut ischemia-reperfusion.Dec 31, 2017

Pubmed Data : Ann Nutr Metab. 2018 ;73(2):131-137. Epub 2018 Jul 27. PMID: 30056446
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Cystine, Theanine
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cystine and Theanine may be beneficial for preventing oxaliplatin-induced peripheral neuropathy.Jul 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Jul 29 ;10(1):12665. Epub 2020 Jul 29. PMID: 32728157
Article Published Date : Jul 28, 2020
Study Type : Animal Study
Additional Links
Substances : Cystine, Theanine
Diseases : Chemotherapy-Induced Toxicity: Oxaliplatin, Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents
[+]

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):65-73. PMID: 30707852
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : GABA (gamma-Aminobutyric Acid), Theanine
Diseases : Sleep Disorders
Additional Keywords : Natural Substance Synergy
[+]

L-theanine alleviates airway inflammation in asthma.Dec 31, 2016

Pubmed Data : Food Chem Toxicol. 2017 Jan ;99:162-169. Epub 2016 Nov 29. PMID: 27908701
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Asthma, Inflammation
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

L-Theanine alleviates MPTP-induced Parkinson's disease.Jan 30, 2023

Pubmed Data : Int J Biol Macromol. 2023 Jan 31 ;226:90-101. Epub 2022 Dec 8. PMID: 36502788
Article Published Date : Jan 30, 2023
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress.Nov 24, 2018

Pubmed Data : Phytother Res. 2018 Nov 25. Epub 2018 Nov 25. PMID: 30474152
Article Published Date : Nov 24, 2018
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

L-theanine ameliorated rotenone-induced Parkinsonism-like symptoms.Jan 05, 2022

Pubmed Data : Neurotox Res. 2022 Jan 6. Epub 2022 Jan 6. PMID: 34988886
Article Published Date : Jan 05, 2022
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease.Jun 30, 2021

Pubmed Data : Drug Chem Toxicol. 2021 Jul 1:1-12. Epub 2021 Jul 1. PMID: 34210222
Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

L-theanine and Neumentix mixture improves sleep quality and modulates brain neurotransmitter levels.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Palliat Med. 2021 Apr ;10(4):4572-4581. PMID: 33966405
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Sleep Disorders
[+]

L-Theanine appears to improve cognitive function in mice. May 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 May;72(5):1356-9. Epub 2008 May 7. PMID: 18460792
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Memory Loss
[+]

L-theanine attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity. Dec 01, 2009

Pubmed Data : Free Radic Biol Med. 2009 Dec 1;47(11):1601-10. Epub 2009 Sep 16. PMID: 19766184
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
[+]

L-theanine attenuates LPS-induced motor deficit in experimental rat model of Parkinson's disease.Jun 30, 2023

Pubmed Data : Psychopharmacology (Berl). 2023 Jul ;240(7):1493-1508. Epub 2023 May 16. PMID: 37191688
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Lipopolysaccharide-Induced Toxicity, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

L-theanine attenuates nicotine reward and withdrawal signs.Jun 10, 2023

Pubmed Data : Neurosci Lett. 2023 Jun 11 ;807:137279. Epub 2023 Apr 25. PMID: 37105354
Article Published Date : Jun 10, 2023
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Nicotine/Tobacco Toxicity
Pharmacological Actions : Anti-Anxiety Agents
[+]

l-Theanine improves functional recovery after traumatic spinal cord injury in rats.Dec 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Formos Med Assoc. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31812333
Article Published Date : Dec 04, 2019
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor
[+]

L-theanine protects against glutamate-induced excitotoxicity in a mouse model.Jul 14, 2010

Pubmed Data : Neuroscience. 2010 Jul 14;168(3):778-86. Epub 2010 Apr 21. PMID: 20416364
Article Published Date : Jul 14, 2010
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Alzheimer's Disease, Excitotoxicity
[+]

l-theanine protects bladder function by suppressing chronic sympathetic hyperactivity in spontaneously hypertensive rat.Nov 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metabolites. 2021 Nov 14 ;11(11). Epub 2021 Nov 14. PMID: 34822436
Article Published Date : Nov 13, 2021
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Hypertension
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

L-theanine reduced the development of knee osteoarthritis.Jul 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jul 3 ;12(7). Epub 2020 Jul 3. PMID: 32635404
Article Published Date : Jul 02, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theanine
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Risk Reduction
[+]

L-theanine significantly and dose-dependently inhibited sepsis induced liver and kidney injury.May 14, 2020

Pubmed Data : Life Sci. 2020 May 15 ;249:117502. Epub 2020 Mar 3. PMID: 32142764
Article Published Date : May 14, 2020
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Kidney Damage, Liver Damage, Oxidative Stress, Sepsis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Renoprotective
[+]

L-theanine supports immune function.Apr 24, 2006

Pubmed Data : Neurosci Lett. 2006 Apr 24;397(3):219-23. Epub 2006 Jan 6. PMID: 18254876
Article Published Date : Apr 24, 2006
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Immune Disorders: Low Immune Function
[+]

L-theanine suppresses food intake in rats, and may lower insulin levels.May 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 May;72(5):1352-5. Epub 2008 May 7. PMID: 18460793
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Appetite Disorders, Hyperinsulinism
[+]

L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail.Dec 31, 2020

Pubmed Data : J Nutr Biochem. 2021 03 ;89:108556. Epub 2020 Nov 26. PMID: 33249185
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theanine
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

L-theanine works synergistically with the drug midazolam to induce an anxiolytic effect. Aug 01, 2010

Pubmed Data : J Altern Complement Med. 2010 Aug;16(8):875-82. PMID: 20108732
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Drug: Midazolam, Drug-Plant-Vitamin Synergies
[+]

L-theanine, Magnolia officinalis, and Melissa officinalis may represent a useful and safe candidate for the management of mood disorders.Jun 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jun 17 ;12(6). Epub 2020 Jun 17. PMID: 32560413
Article Published Date : Jun 16, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lemon Balm, Magnolia, Theanine
Diseases : Anxiety, Depression, Mood Disorders
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Neuroprotective effect of l-theanine in a rat model of chronic constriction injury of sciatic nerve-induced neuropathic pain.Sep 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Formos Med Assoc. 2021 Sep 13. Epub 2021 Sep 13. PMID: 34531102
Article Published Date : Sep 12, 2021
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Neuropathic Pain, Sciatic Nerve Crush Injury
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Protective effect of l-theanine against DSS-induced colitis.Nov 30, 2021

Pubmed Data : J Agric Food Chem. 2021 Dec 1 ;69(47):14192-14203. Epub 2021 Nov 16. PMID: 34784210
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Colitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Protective effect of l-theanine on cyclophosphamide-induced testicular toxicity.May 30, 2023

Pubmed Data : J Agric Food Chem. 2023 May 31 ;71(21):8050-8060. Epub 2023 May 17. PMID: 37198140
Article Published Date : May 30, 2023
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Cytoprotective
[+]

Protective effects of a cystine and theanine mixture against acute radiation injury.Jul 31, 2020

Pubmed Data : Environ Toxicol Pharmacol. 2020 Aug ;78:103395. Epub 2020 Apr 17. PMID: 32325407
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Cystine, Theanine
Diseases : Radiation
Pharmacological Actions : Radioprotective
[+]

Protective effects of L-theanine against doxorubicin-induced nephrotoxicity.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:1524-1534. Epub 2018 Oct 9. PMID: 30372854
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Stress-reducing effect of cookies containing matcha green tea: essential ratio among theanine, arginine, caffeine and epigallocatechin gallate.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2019 May ;5(5):e01653. Epub 2019 May 7. PMID: 31111111
Article Published Date : Apr 30, 2019
Study Type : Animal Study
Additional Links
Substances : Green Tea, Theanine
Diseases : Stress
[+]

The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms.Nov 30, 2018

Pubmed Data : Nutr Res. 2018 Dec ;60:116-131. Epub 2018 Oct 2. PMID: 30527255
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Luteolin, Theanine
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Theanine improves high-dose epigallocatechin-3-gallate-induced lifespan reduction in caenorhabditis elegans.Jun 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2021 Jun 17 ;10(6). Epub 2021 Jun 17. PMID: 34204441
Article Published Date : Jun 16, 2021
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theanine
Diseases : Aging
Pharmacological Actions : Antioxidants
[+]

Theanine may assist in healthy brain function development in the offspring of those who consume it while lactating. Mar 01, 2007

Pubmed Data : Atherosclerosis. 2007 Mar;191(1):162-7. Epub 2006 Apr 17. PMID: 17904164
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Postnatal Care: Breastfeeding
Pharmacological Actions : Neuritogenic
[+]

Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Jul 01, 2008

Pubmed Data : Cancer Res. 2008 Jul 1;68(13):5345-54. PMID: 17705146
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Brain Ischemia, Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Theanine significantly enhanced the repression of liver cancer cell growth in combination with anticancer drug pirarubicin.Sep 08, 2016

Pubmed Data : J Agric Food Chem. 2016 Sep 9. Epub 2016 Sep 9. PMID: 27569455
Article Published Date : Sep 08, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theanine
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Theanine significantly suppressed human cervical tumor growth in tumor-bearing nude mice without toxicity.Sep 05, 2016

Pubmed Data : Eur J Pharmacol. 2016 Sep 6. Epub 2016 Sep 6. PMID: 27612630
Article Published Date : Sep 05, 2016
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Theanine suppresses oxygen-induced retinal neovascularization associated in a rat model of retinopathy. Aug 01, 2008

Pubmed Data : Nippon Ganka Gakkai Zasshi. 2008 Aug;112(8):669-73. PMID: 18767491
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Corneal Neovascularization, Retinopathy of Prematurity, Retrolental Fibroplasia
[+]

These results suggest a potential role of L-Theanine in combating diet-induced obesity.Apr 15, 2021

Pubmed Data : Diabetes. 2021 Apr 16. Epub 2021 Apr 16. PMID: 33863801
Article Published Date : Apr 15, 2021
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

This study clearly indicates the potential of L-Theanine in counteracting the damage inflicted by aluminium on rat brain regions.Dec 31, 2014

Pubmed Data : Drug Chem Toxicol. 2015 Jan ;38(1):22-31. Epub 2014 Mar 24. PMID: 24654859
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Aluminum Toxicity , Lipid Peroxidation, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Through its powerful antioxidative properties, L-theanine ameliorates vincristine-induced neuropathy.Mar 24, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2023 Mar 25 ;12(4). Epub 2023 Mar 25. PMID: 37107178
Article Published Date : Mar 24, 2023
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.Sep 22, 2020

Pubmed Data : Food Funct. 2020 Sep 23 ;11(9):8369-8379. PMID: 32935679
Article Published Date : Sep 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Pharmacological Actions : Immunomodulatory
[+]

L-theanine alleviates IMQ-induced psoriasis like skin inflammation.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:719842. Epub 2021 Jul 26. PMID: 34381369
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-23 Downregulation, NF-kappaB Inhibitor
[+]

L-theanine and caffeine have clear beneficial effects on sustained attention, memory, and suppression of distraction.Jan 04, 2017

Pubmed Data : Curr Pharm Des. 2017 Jan 5. Epub 2017 Jan 5. PMID: 28056735
Article Published Date : Jan 04, 2017
Study Type : Review
Additional Links
Substances : Caffeine, Theanine
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

l-Theanine attenuates liver aging by inhibiting advanced glycation end products.Feb 29, 2020

Pubmed Data : Exp Gerontol. 2020 Mar ;131:110823. Epub 2019 Dec 31. PMID: 31899338
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Advanced Glycation End products (AGE), Aging: Liver, Liver Damage
Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Antioxidants
[+]

L-Theanine inhibits melanoma cell growth and migration.Sep 19, 2021

Pubmed Data : Eur J Nutr. 2021 Sep 20. Epub 2021 Sep 20. PMID: 34542664
Article Published Date : Sep 19, 2021
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Melanoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Gene Expression Regulation
[+]

L-theanine provides neuroprotection against Parkinson's disease related pesticide neurotoxicants. Jul 01, 2008

Pubmed Data : Neurotoxicology. 2008 Jul;29(4):656-62. Epub 2008 Mar 20. PMID: 18452993
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Parkinson's Disease, Pesticide Toxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective attributes of L-theanine, a bioactive amino acid of tea, and its potential role in Parkinson's disease therapeutics.May 26, 2019

Pubmed Data : Neurochem Int. 2019 May 27:104478. Epub 2019 May 27. PMID: 31145971
Article Published Date : May 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effects of L-theanine on IPEC-J2 cells growth inhibition induced by dextran sulfate sodium.Nov 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Nov 19 ;26(22). Epub 2021 Nov 19. PMID: 34834090
Article Published Date : Nov 18, 2021
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Pharmacological Actions : Cytoprotective
[+]

Supplementation of L-theanine may assist in the reduction of stress and anxiety in people exposed to stressful conditions.Nov 21, 2019

Pubmed Data : Plant Foods Hum Nutr. 2019 Nov 22. Epub 2019 Nov 22. PMID: 31758301
Article Published Date : Nov 21, 2019
Study Type : Review
Additional Links
Substances : Green Tea, Theanine
Diseases : Anxiety
Pharmacological Actions : Anti-Anxiety Agents
[+]

Synergistic effects of epigallocatechin gallate and l-theanine in nerve repair and regeneration.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2022 ;9:951415. Epub 2022 Aug 10. PMID: 36034895
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theanine
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy.Feb 20, 2023

Pubmed Data : Food Funct. 2023 Feb 21 ;14(4):2059-2073. Epub 2023 Feb 21. PMID: 36727615
Article Published Date : Feb 20, 2023
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theanine
Diseases : Food Allergies
Pharmacological Actions : Immunomodulatory
Additional Keywords : Natural Substance Synergy
[+]

Theanine enhances the antitumor efficacy of chemotherapeutic agents. Dec 05, 2003

Pubmed Data : Biochim Biophys Acta. 2003 Dec 5;1653(2):47-59. PMID: 14643924
Article Published Date : Dec 05, 2003
Study Type : Review
Additional Links
Substances : Theanine
Diseases : Cancers: All, Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Enzyme Inhibitors
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Theanine inhibits the growth of leukemia and non-small cell lung cancer cells and enhances the anticancer activity of anticancer drugs. Apr 01, 2009

Pubmed Data : Cytotechnology. 2009 Apr;59(3):211-7. Epub 2009 Sep 17. PMID: 19760127
Article Published Date : Apr 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Leukemia, Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Anti-metastatic
Additional Keywords : Drug: Norcantharidin, Drug-Plant-Vitamin Synergies
[+]

Theanine inhibits the invasion of hepatoma cells. Jul 01, 2001

Pubmed Data : Cytotechnology. 2001 Jul;36(1-3):195-200. PMID: 19003331
Article Published Date : Jul 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Cancer Metastasis, Hepatoma
Pharmacological Actions : Anti-metastatic
[+]

Theanine prevents stress-induced brain atrophy by modifying early stress responses.Jan 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jan 8 ;12(1). Epub 2020 Jan 8. PMID: 31936294
Article Published Date : Jan 07, 2020
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Stress
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Gene Expression Regulation
[+]

These findings demonstrated that the neuroprotective role of theanine was associated with its anti-oxidative, anti-inflammatory, and anti-apoptotic properties.Jan 14, 2020

Pubmed Data : Life Sci. 2020 Jan 15 ;241:117160. Epub 2019 Dec 13. PMID: 31837331
Article Published Date : Jan 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Brain Ischemia, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These observations suggested that theanine exerted potent cytotoxicity on tumor cells when glutamine was restricted.Oct 31, 2018

Pubmed Data : Mol Med Rep. 2018 Nov ;18(5):4535-4542. Epub 2018 Sep 5. PMID: 30221698
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theanine
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic

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