Thymol

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65 Diseases Researched for Thymol
NameACCKFocus
Alzheimer's Disease59Locked
Lipopolysaccharide-Induced Toxicity47Locked
Staphylococcus aureus infection67Locked
High Fat Diet36Locked
Candida Albicans45Locked
Inflammation35Locked
Diabetic Complications24Locked
Gastric Ulcer24Locked
Oxidative Stress34Locked
Colorectal Cancer23Locked
Lung Injury: Acute23Locked
Obesity23Locked
Radiation Induced Illness23Locked
Acinetobacter baumannii infection12Locked
Allergic Rhinitis12Locked
Brain Inflammation 12Locked
Brain: Oxidative Stress12Locked
Cancers: All22Locked
Chemically-Induced Liver Damage12Locked
Chemotherapy and Radiation Toxicity12Locked
Chemotherapy-Induced Kidney Damage12Locked
Chemotherapy-Induced Toxicity: Cisplatin12Locked
Cognitive Decline/Dysfunction12Locked
Dementia12Locked
Diabetes: Cataract12Locked
Diabetic Nephropathy12Locked
Drug-Induced Toxicity: Indomethacin12Locked
Endometritis12Locked
Gastric Cancer22Locked
Insulin Resistance12Locked
Leishmaniasis12Locked
Lipid Peroxidation12Locked
Mitochondrial Dysfunction 12Locked
Myocardial Infarction12Locked
Parkinson's Disease12Locked
Salmonella Infections22Locked
Staphylococcus aureus: Methicillin-resistant (MRSA)12Locked
Toxoplasma gondii Infection12Locked
Toxoplasmosis12Locked
Acetaminophen (Tylenol) Toxicity 11Locked
Acute Myeloid Leukemia11Locked
Bladder Cancer11Locked
Brain Cancer11Locked
Candida Infection 11Locked
Carcinoma: Non-Small-Cell Lung11Locked
Clostridium Infections11Locked
Coronavirus Infection11Locked
DNA damage11Locked
Dental Caries11Locked
Escherichia coli Infections11Locked
Foodborne Pathogens: Prevention/Food Preservation11Locked
Fungal Infection11Locked
Gout11Locked
Gram-Negative Bacterial Infections11Locked
Herpes Simplex Virus Type 111Locked
Hyperuricemia11Locked
Immune Dysregulation: TH1 dominance11Locked
Immune Dysregulation: TH17 over-expression11Locked
Osteoporosis11Locked
Prostate Cancer11Locked
Pseudomonas aeruginosa11Locked
Respiratory Tract Infections11Locked
Staphylococcus epidermidis11Locked
Steptococcus Mutans Infections11Locked
Wound Healing11Locked
44 Pharmacological Actions Researched for Thymol
NameACCKFocus
Antioxidants1625Locked
Anti-Inflammatory Agents1117Locked
Anti-Bacterial Agents1114Locked
Neuroprotective Agents59Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor59Locked
Interleukin-1 beta downregulation47Locked
Antifungal Agents56Locked
Antiproliferative 56Locked
Apoptotic55Locked
Radioprotective35Locked
Anti-Ulcer Agents24Locked
Antimicrobial44Locked
NF-kappaB Inhibitor24Locked
Renoprotective24Locked
Cardioprotective23Locked
Heme oxygenase-1 up-regulation23Locked
Hepatoprotective23Locked
Interleukin-6 Downregulation23Locked
Nrf2 activation23Locked
Anti-metastatic12Locked
Antimutagenic Agents12Locked
Antiparasitic Agents12Locked
Antiviral Agents22Locked
Cell cycle arrest22Locked
Chemoprotective Agents12Locked
Cholinesterase Inhibitors12Locked
Cyclooxygenase 2 Inhibitors12Locked
Cytotoxicity22Locked
Gastroprotective12Locked
Hypoglycemic Agents12Locked
Hypolipidemic12Locked
Immunomodulatory22Locked
Interleukin-8 downregulation12Locked
Leishmanicidal12Locked
Malondialdehyde Down-regulation12Locked
Vascular Endothelial Growth Factor Inhibitors12Locked
Wnt/β-catenin signaling pathway modulation12Locked
Bcl-2 protein down-regulation11Locked
Chemotherapeutic11Locked
Genoprotective11Locked
Immunomodulatory: Th17 downregulation11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Osteoprotective 11Locked
Xanthine oxidase inhibitor11Locked

View the Evidence:
101 Abstracts with Thymol Research

[+]

Thymol protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease.Feb 09, 2022

Pubmed Data : BMC Complement Med Ther. 2022 Feb 10 ;22(1):40. Epub 2022 Feb 10. PMID: 35144603
Article Published Date : Feb 09, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymol
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Cardioprotective effect of thymol against adrenaline-induced myocardial injury in rats.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Jul ;6(7):e04431. Epub 2020 Jul 21. PMID: 32715125
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Thymol
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor
[+]

Administration of thymol afforded remarkable protection against high fat diet induced diabetic nephropathy.Feb 04, 2016

Pubmed Data : Chem Biol Interact. 2016 Feb 5 ;245:1-11. Epub 2015 Dec 8. PMID: 26680107
Article Published Date : Feb 04, 2016
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Diabetic Nephropathy, High Fat Diet
Pharmacological Actions : Renoprotective, Vascular Endothelial Growth Factor Inhibitors
[+]

Both hesperidin and thymol were effective in suppressing allergic symptoms and inflammation in the treatment of allergic rhinitis.Nov 27, 2018

Pubmed Data : Eur Arch Otorhinolaryngol. 2018 Nov 28. Epub 2018 Nov 28. PMID: 30488351
Article Published Date : Nov 27, 2018
Study Type : Animal Study
Additional Links
Substances : Hesperidin, Thymol
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Cognitive-enhancing activity of thymol and carvacrol in two rat models of dementia.May 31, 2012

Pubmed Data : Behav Pharmacol. 2012 Jun ;23(3):241-9. PMID: 22470103
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Alzheimer's Disease, Dementia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cholinesterase Inhibitors
[+]

Discovery of small molecule acting as multitarget inhibitor of colorectal cancer.Sep 30, 2021

Pubmed Data : Bioorg Chem. 2021 Oct ;115:105171. Epub 2021 Jul 16. PMID: 34303896
Article Published Date : Sep 30, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymol
Diseases : Colorectal Cancer
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Antiproliferative , Cyclooxygenase 2 Inhibitors
[+]

Estragole and thymol display important anti-Toxoplasma activity.Feb 01, 2016

Pubmed Data : J Parasitol. 2016 Feb 2. Epub 2016 Feb 2. PMID: 26836848
Article Published Date : Feb 01, 2016
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Toxoplasma gondii Infection, Toxoplasmosis
Pharmacological Actions : Antiparasitic Agents
[+]

Evaluation of the antibacterial activity and efflux pump reversal of thymol and carvacrol against Staphylococcus aureus.Apr 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Apr 30 ;25(9). Epub 2020 Apr 30. PMID: 32365898
Article Published Date : Apr 29, 2020
Study Type : Insect Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcerNov 13, 2018

Pubmed Data : Drug Chem Toxicol. 2018 Nov 14:1-13. Epub 2018 Nov 14. PMID: 30426792
Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Oleuropein, Thymol
Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Problem Substances : Indomethacin
[+]

Hepatoprotective role of thymol in drug-induced gastric ulcer model.Oct 15, 2018

Pubmed Data : Ann Hepatol. 2018 Oct 16 ;17(6):980-991. PMID: 30600301
Article Published Date : Oct 15, 2018
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents
[+]

In vitro data demonstrated concentration-dependent thymol inhibition of both C. albicans growth and biofilm formation.Jan 18, 2016

Pubmed Data : Immunol Res. 2016 Jan 19. Epub 2016 Jan 19. PMID: 26783030
Article Published Date : Jan 18, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
[+]

Isolation of thymol from Trachyspermum ammi fruits for treatment of diabetes and diabetic neuropathy in STZ-induced rats.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:8263999. Epub 2022 Apr 28. PMID: 35528161
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Diabetic Neuropathy
Pharmacological Actions : Hypolipidemic, Renoprotective
[+]

Neuroprotective effects of phytochemicals against aluminum chloride-induced Alzheimer's Disease.Aug 16, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Aug 17 ;15(8). Epub 2022 Aug 17. PMID: 36015156
Article Published Date : Aug 16, 2022
Study Type : Animal Study
Additional Links
Substances : Thymol, Thymoquinone
Diseases : Aluminum Toxicity , Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Problem Substances : Aluminum Chloride
[+]

Neuroprotective effects of some nutraceuticals against manganese-induced parkinson's disease.Dec 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Dec 14 ;15(12). Epub 2022 Dec 14. PMID: 36559006
Article Published Date : Dec 13, 2022
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10, Sesamol, Thymol
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Neuroprotective role of a monoterpene (thymol) on diazepam induced withdrawal symptoms.Jun 30, 2021

Pubmed Data : Pak J Pharm Sci. 2021 Jul ;34(4(Supplementary)):1615-1620. PMID: 34799339
Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Benzodiazepine Dependence/Withdrawal
Pharmacological Actions : Neuroprotective Agents
[+]

The present study showed protective effects of thymol in rotenone-induced neurotoxicity and neurodegeneration.Mar 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Mar 27 ;20(7). Epub 2019 Mar 27. PMID: 30934738
Article Published Date : Mar 26, 2019
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The protective effect of thymoquinone or/and thymol against monosodium glutamate-induced attention-deficit/hyperactivity disorder.Oct 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Nov ;155:113799. Epub 2022 Oct 6. PMID: 36271575
Article Published Date : Oct 31, 2022
Study Type : Animal Study
Additional Links
Substances : Thymol, Thymoquinone
Diseases : Attention Deficit Disorder with Hyperactivity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Monosodium Glutamate (MSG)
[+]

The protective effects of thymol and carvacrol against di (2-ethylhexyl) phthalate-induced cytotoxicity in HEK-293 cells.May 05, 2022

Pubmed Data : J Biochem Mol Toxicol. 2022 May 6:e23092. Epub 2022 May 6. PMID: 35521929
Article Published Date : May 05, 2022
Study Type : Animal Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Kidney Damage: Chemically-Induced, Phthalate Toxicity
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Phthalates
[+]

The protective efficacy of hesperidin and thymol on radiation-induced submandibular gland damage.Sep 22, 2022

Pubmed Data : Laryngoscope. 2022 Sep 23. Epub 2022 Sep 23. PMID: 36149936
Article Published Date : Sep 22, 2022
Study Type : Animal Study
Additional Links
Substances : Hesperidin, Thymol
Diseases : Radiotherapy
Pharmacological Actions : Antioxidants, Radioprotective
[+]

The results showed renoprotective effects of Zataria multiflora extract, carvacrol, and thymol in Cis-induced nephrotoxicity.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:8847212. Epub 2021 Jan 25. PMID: 33574884
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Carvacrol, Thymol, Zataria multiflora
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

The Zataria multiflora extract had a potent bactericidal effect against A. baumannii that could downregulate the ompA gene.Jul 23, 2019

Pubmed Data : J Cell Biochem. 2019 Jul 24. Epub 2019 Jul 24. PMID: 31338900
Article Published Date : Jul 23, 2019
Study Type : Animal Study
Additional Links
Substances : Carvacrol, Thymol, Zataria multiflora
Diseases : Acinetobacter baumannii infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Gene Expression
[+]

This study clearly documents the antioxidant, anticlastogenic and radioprotective potentials of thymol.Dec 23, 2011

Pubmed Data : Mutat Res. 2011 Dec 24 ;726(2):136-45. Epub 2011 Sep 14. PMID: 21933721
Article Published Date : Dec 23, 2011
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Lipid Peroxidation, Radiation Induced Illness
Pharmacological Actions : Antimutagenic Agents, Antioxidants, Radioprotective
[+]

Thyme oil and thymol counter doxorubicin-induced hepatotoxicityDec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:6702773. Epub 2022 Feb 7. PMID: 35178158
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Thyme, Thymol
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Chemoprotective Agents, Hepatoprotective
Additional Keywords : Drug: Doxorubicin
[+]

Thymol and carvacrol are highly promising candidates for the development of effective and safe drugs in the fight against visceral leishmaniasis.May 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 May 30 ;24(11). Epub 2019 May 30. PMID: 31151304
Article Published Date : May 29, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Thymol can be therapeutic against high risk factors for Alzheimer's disease.Jan 12, 2018

Pubmed Data : Brain Res Bull. 2018 Jan 13 ;137:338-350. Epub 2018 Jan 13. PMID: 29339105
Article Published Date : Jan 12, 2018
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Alzheimer's Disease, Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Thymol could be a potential therapeutic option for imidacloprid reprotoxic impacts.Sep 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2021 Sep 15 ;221:112435. Epub 2021 Jun 22. PMID: 34171690
Article Published Date : Sep 14, 2021
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Oxidative Stress, Pesticide Toxicity , Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

Thymol could potentially act as natural therapeutic agents for the treatment of neurodegenerative disorders, such as Alzheimer's disease.Feb 19, 2023

Pubmed Data : Phytother Res. 2023 Feb 20. Epub 2023 Feb 20. PMID: 36808768
Article Published Date : Feb 19, 2023
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Alzheimer's Disease
Pharmacological Actions : Neurogenesis, Neuroprotective Agents
[+]

Thymol decreased the effects of Aβ on memory and could be considered as neuroprotective.Mar 01, 2017

Pubmed Data : Metab Brain Dis. 2017 Mar 2. Epub 2017 Mar 2. PMID: 28255862
Article Published Date : Mar 01, 2017
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Alzheimer's Disease, High Fat Diet, Obesity
Pharmacological Actions : Neuroprotective Agents
[+]

Thymol effectively protects against nano titanium dioxide-induced hepatotoxicity in rats by its antioxidant properties.Dec 16, 2017

Pubmed Data : Environ Toxicol Pharmacol. 2017 Dec 17 ;58:29-36. Epub 2017 Dec 17. PMID: 29289817
Article Published Date : Dec 16, 2017
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Problem Substances : Titanium Nanoparticles
[+]

Thymol exhibited beneficial effects on HFD-induced cognitive deficits through improving hippocampal insulin resistance.Oct 19, 2016

Pubmed Data : Metab Brain Dis. 2016 Oct 20. Epub 2016 Oct 20. PMID: 27761760
Article Published Date : Oct 19, 2016
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Cognitive Decline/Dysfunction, High Fat Diet, Insulin Resistance
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Thymol had a unique effect on reducing bone marrow and liver cell-tissue changes due to the acetaminophen toxicity.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anal Cell Pathol (Amst). 2023 ;2023:1714884. Epub 2023 Apr 4. PMID: 37056637
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Thyme, Thymol
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
[+]

Thymol has beneficial effects on diabetic complications.Aug 12, 2018

Pubmed Data : Drug Res (Stuttg). 2018 Aug 13. Epub 2018 Aug 13. PMID: 30103218
Article Published Date : Aug 12, 2018
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Diabetic Complications
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Hypolipidemic
[+]

Thymol improves autism-like behaviour in VPA-induced autism spectrum disorders.Mar 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2023 Apr ;117:109885. Epub 2023 Feb 27. PMID: 36842231
Article Published Date : Mar 31, 2023
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Autism Spectrum Disorders, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Thymol improves barrier function and attenuates inflammatory responses in intestinal epithelial cells during lipopolysaccharide induced inflammation.Dec 18, 2018

Pubmed Data : J Agric Food Chem. 2018 Dec 19. Epub 2018 Dec 19. PMID: 30567427
Article Published Date : Dec 18, 2018
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymol inhibits biofilm formation, eliminates pre-existing biofilms, and enhances clearance of methicillin-resistant Staphylococcus aureus.Jan 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microorganisms. 2020 Jan 10 ;8(1). Epub 2020 Jan 10. PMID: 31936809
Article Published Date : Jan 09, 2020
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Thymol isolated from Thymus vulgaris L. inhibits colorectal cancer cell growth and metastasis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:2535-2547. Epub 2020 Jul 1. PMID: 32669835
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymol
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Thymol may be a potential therapeutic approach in the prevention of diabetic complications.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Bioallied Sci. 2016 Oct-Dec;8(4):277-283. PMID: 28216950
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Diabetes: Cataract, Diabetic Complications
Pharmacological Actions : Antioxidants
[+]

Thymol might be useful in the therapy of acute lung injury.Oct 09, 2017

Pubmed Data : Inflammation. 2017 Oct 10. Epub 2017 Oct 10. PMID: 29019091
Article Published Date : Oct 09, 2017
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymol mitigates cadmium-induced behavioral and cognitive deficits.Feb 28, 2022

Pubmed Data : Pak J Pharm Sci. 2022 Mar ;35(2(Special)):671-678. PMID: 35668569
Article Published Date : Feb 28, 2022
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Anxiety, Cadmium Poisoning
Pharmacological Actions : Anti-Anxiety Agents, Brain-derived neurotrophic factor modulator, Neuroprotective Agents
Problem Substances : Cadmium
[+]

Thymol mitigates lipopolysaccharide-induced endometritis.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 21 ;8(12):20042-20055. PMID: 28223539
Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymol
Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymol pre and co-treatment showed near normalized effects on all the biochemical parameters studied.Jan 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Jan 25 ;244:159-68. Epub 2015 Dec 22. PMID: 26721194
Article Published Date : Jan 24, 2016
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Mitochondrial Dysfunction , Myocardial Infarction, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Thymol significantly protected acute and chronic salivary gland dysfunction induced by ionizing radiation in the rats.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2016 ;15(4):861-866. PMID: 28243283
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Radioprotective
Anti Therapeutic Actions : Low Dose Ionizing Radiation
[+]

Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation.Dec 31, 2017

Pubmed Data : Hum Exp Toxicol. 2018 Jan 1:960327118755256. Epub 2018 Jan 1. PMID: 29405769
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Synergistic antimicrobial combination of carvacrol and thymol impairs single and mixed-species biofilms of Candida albicans and Staphylococcus epidermidis Jan 10, 2020

Pubmed Data : Biofouling. 2020 11 ;36(10):1256-1271. Epub 2021 Jan 12. PMID: 33435734
Article Published Date : Jan 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Candida Albicans, Staphylococcus epidermidis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Natural Substance Synergy
[+]

A review of the anti-cancer activity of thymol.Oct 10, 2018

Pubmed Data : IUBMB Life. 2018 Oct 11. Epub 2018 Oct 11. PMID: 30308112
Article Published Date : Oct 10, 2018
Study Type : Review
Additional Links
Substances : Thymol
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
[+]

An in-depth view of potential dual effect of thymol in inhibiting xanthine oxidase activity.Aug 06, 2018

Pubmed Data : Int J Biol Macromol. 2018 Aug 7. Epub 2018 Aug 7. PMID: 30096398
Article Published Date : Aug 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Cancers: All, Gout, Hyperuricemia
Pharmacological Actions : Xanthine oxidase inhibitor
[+]

Anti-biofilm activities of essential oils rich in carvacrol and thymol against Salmonella Enteritidis.Feb 28, 2019

Pubmed Data : Biofouling. 2019 Mar ;35(3):361-375. Epub 2019 May 14. PMID: 31088182
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Salmonella Infections
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Essential Oils
[+]

Antifungal activity of thymol and carvacrol against postharvest pathogens Botrytis cinerea.Apr 30, 2019

Pubmed Data : J Food Sci Technol. 2019 May ;56(5):2611-2620. Epub 2019 Apr 15. PMID: 31168143
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Pharmacological Actions : Antifungal Agents
Additional Keywords : Plant Disease
[+]

Antioxidant efficacy of thymol and carvacrol in microencapsulated walnut oil triacylglycerols.Apr 24, 2019

Pubmed Data : Food Chem. 2019 Apr 25 ;278:805-810. Epub 2018 Dec 4. PMID: 30583446
Article Published Date : Apr 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol, Walnut
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Oils
[+]

Antitumor effects of carvacrol and thymol: A systematic review. Dec 31, 2020

Pubmed Data : Front Pharmacol. 2021 ;12:702487. Epub 2021 Jul 7. PMID: 34305611
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Substances : Carvacrol, Thymol
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Biotechnological potential of eugenol and thymol derivatives against staphylococcus aureus from bovine mastitis.Apr 30, 2021

Pubmed Data : Curr Microbiol. 2021 May ;78(5):1846-1855. Epub 2021 Apr 16. PMID: 33861370
Article Published Date : Apr 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Eugenol, Thymol
Diseases : Mastitis, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Carvacrol and thymol inhibit biofilm formation of carbapenemase-producing gram negative bacilli strains.May 19, 2017

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2017 May 20 ;63(5):108-112. Epub 2017 May 20. PMID: 28719354
Article Published Date : May 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Gram-Negative Bacterial Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Biofilm
[+]

Carvacrol and thymol isolated from O. vulgare L. exhibit good bactericidal and antibiofilm activity against S. mutans.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : AMB Express. 2017 Dec ;7(1):49. Epub 2017 Feb 23. PMID: 28233286
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Oregano, Thymol
Diseases : Dental Caries, Steptococcus Mutans Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Biofilm
[+]

Carvacrol, cinnamaldehyde, thymol, or oregano oil inhibit Clostridum prefringens in beef.Jul 01, 2006

Pubmed Data : J Food Prot. 2006 Jul;69(7):1546-51. PMID: 16865884
Article Published Date : Jul 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Cinnamaldehyde, Cinnamon, Oregano, Thyme, Thymol
Diseases : Clostridium Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Combination of carvacrol and thymol has antimicrobial activity against Staphylococcus aureus and antioxidant activity.Apr 18, 2019

Pubmed Data : Foodborne Pathog Dis. 2019 Apr 19. Epub 2019 Apr 19. PMID: 31009261
Article Published Date : Apr 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
[+]

Combined effect of carvacrol, thymol and nisin against Staphylococcus aureus and Salmonella Enteritidis.Dec 31, 2020

Pubmed Data : An Acad Bras Cienc. 2021 ;93(suppl 4):e20210550. Epub 2021 Nov 1. PMID: 34730626
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Nisin, Thymol
Diseases : Salmonella Infections, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
[+]

Computational evaluation of major components from plant essential oils as potent inhibitors of SARS-CoV-2 spike protein.Dec 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Mol Struct. 2020 Dec 5 ;1221:128823. Epub 2020 Jul 4. PMID: 32834111
Article Published Date : Dec 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Cinnamaldehyde, Geraniol , Thymol
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
Additional Keywords : Essential Oils
[+]

Effect of carvacrol and thymol on NorA efflux pump inhibition in multidrug-resistant (MDR) Staphylococcus aureus strains.Jun 21, 2021

Pubmed Data : J Bioenerg Biomembr. 2021 Jun 22. Epub 2021 Jun 22. PMID: 34159523
Article Published Date : Jun 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Infection: Antibiotic Resistant, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Effects of carvacrol, thymol and essential oils containing such monoterpenes on wound healing: a systematic review.Jan 31, 2019

Pubmed Data : J Pharm Pharmacol. 2019 Feb ;71(2):141-155. Epub 2018 Dec 7. PMID: 30537169
Article Published Date : Jan 31, 2019
Study Type : Review
Additional Links
Substances : Carvacrol, Thymol
Diseases : Oxidative Stress, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Essential Oils
[+]

Effects of thymol on human gastric adenocarcinoma cells in vitro.Feb 23, 2018

Pubmed Data : Altern Ther Health Med. 2018 Feb 24. Epub 2018 Feb 24. PMID: 29477139
Article Published Date : Feb 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Apoptotic, gastric cancer, Thymol
[+]

Eugenol and thymol, alone or in combination, induce morphological alterations in the envelope of Candida albicans.Aug 31, 2007

Pubmed Data : Fitoterapia. 2007 Sep ;78(6):396-400. Epub 2007 May 23. PMID: 17590533
Article Published Date : Aug 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Eugenol, Thymol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
Additional Keywords : Natural Substance Synergy
[+]

Experimental treatment of cystic echinococcosis: combination therapy with carvacrol and thymol versus albendazole.Dec 31, 2022

Pubmed Data : Exp Parasitol. 2023 Jan ;244:108430. Epub 2022 Nov 23. PMID: 36435216
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Echinococcosis
Pharmacological Actions : Antiparasitic Agents
[+]

Extracts of thyme and primrose with the addition of thymol was comparable to synthetic ambroxol.Dec 31, 2015

Pubmed Data : Wiad Lek. 2016 ;69(6):791-798. PMID: 28214817
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Evening Primrose Oil, Thyme, Thymol
Diseases : Respiratory Tract Infections
Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Antioxidants
Additional Keywords : Natural Substances Versus Drugs
[+]

In vitro activities of carvacrol, cinnamaldehyde and thymol against Candida biofilms.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Nov ;143:112218. Epub 2021 Sep 28. PMID: 34649348
Article Published Date : Oct 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Cinnamaldehyde, Thymol
Diseases : Candida Albicans, Candidiasis
Pharmacological Actions : Antifungal Agents
[+]

In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates.Sep 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Antibiot (Tokyo). 2022 Sep 27. Epub 2022 Sep 27. PMID: 36167781
Article Published Date : Sep 26, 2022
Study Type : In Vitro Study
Additional Links
Substances : Celastrol, Thymol
Diseases : Klebsiella Infections
[+]

In vitro anti-biofilm activities of citral and thymol against candida tropicalis.Feb 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Fungi (Basel). 2019 Feb 3 ;5(1). Epub 2019 Feb 3. PMID: 30717454
Article Published Date : Feb 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citral, Thymol
Diseases : Candida Infection
Pharmacological Actions : Antifungal Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Inhibitory effect of thymol on tympanostomy tube biofilms of methicillin-resistant Staphylococcus aureus and ciprofloxacin-resistant Pseudomonas aeruginosa.Sep 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microorganisms. 2022 Sep 19 ;10(9). Epub 2022 Sep 19. PMID: 36144469
Article Published Date : Sep 18, 2022
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Pseudomonas aeruginosa, Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
[+]

Inhibitory effects of thymol on the cytotoxicity and inflammatory responses induced by Staphylococcus aureus extracellular vesicles.Jun 17, 2019

Pubmed Data : Microb Pathog. 2019 Jun 18 ;134:103603. Epub 2019 Jun 18. PMID: 31226290
Article Published Date : Jun 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents
Additional Keywords : Exosomes
[+]

New anti-leukemic effect of carvacrol and thymol combination through synergistic induction of different cell death pathways. Jan 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Jan 14 ;26(2). Epub 2021 Jan 14. PMID: 33466806
Article Published Date : Jan 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Potentiating the activity of berberine for Staphylococcus aureus in a combinatorial treatment with thymol.Sep 29, 2020

Pubmed Data : Microb Pathog. 2020 Sep 30 ;149:104542. Epub 2020 Sep 30. PMID: 33010366
Article Published Date : Sep 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Berberine, Thymol
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance Synergy
[+]

Studies with fresh meat, meat products, fish, milk, dairy products and cooked rice have shown that the concentration of essential oils needed to achieve a significant antibacterial effect is around 0.5 microl g (-1) in foods and about .1 - 10 microl ml (-Aug 01, 2004

Pubmed Data : Int J Food Microbiol. 2004 Aug 1 ;94(3):223-53. PMID: 15246235
Article Published Date : Aug 01, 2004
Study Type : Bacterial
Additional Links
Substances : Carvacrol, Cinnamaldehyde, Cinnamic acid, Eugenol, Perillaldehyde, Thymol
Diseases : Foodborne Pathogens: Prevention/Food Preservation
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Food Preservation With Essential Oils
[+]

Synergistic activity of thymol with commercial antibiotics against critical and high WHO priority pathogenic bacteria.May 01, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2023 May 2 ;12(9). Epub 2023 May 2. PMID: 37176927
Article Published Date : May 01, 2023
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Acinetobacter baumannii infection, Bacillus subtilis infections, Klebsiella Infections, Salmonella Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Synergistic antibiofilm efficacy of thymol and piperine in combination with three aminoglycoside antibiotics against Klebsiella pneumoniae biofilms.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Can J Infect Dis Med Microbiol. 2021 ;2021:7029944. Epub 2021 Nov 8. PMID: 34790281
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Piperine, Thymol
Diseases : Klebsiella Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Natural Substance/Drug Synergy
[+]

Synergistic inactivation of Escherichia coli O157:H7 and Staphylococcus aureus by gallic acid and thymol and its potential application on fresh-cut tomatoes.Mar 31, 2022

Pubmed Data : Food Microbiol. 2022 Apr ;102:103925. Epub 2021 Oct 19. PMID: 34809951
Article Published Date : Mar 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid, Thymol
Diseases : Escherichia coli Infections, Foodborne Pathogens: Prevention/Food Preservation, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance Synergy
[+]

Synergistic interaction of piperine and thymol on attenuation of the biofilm formation, hyphal morphogenesis and phenotypic switching in Candida albicans.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Infect Microbiol. 2021 ;11:780545. Epub 2022 Jan 19. PMID: 35127553
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Piperidines, Thymol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Natural Substance Synergy
[+]

The antibacterial mechanism of carvacrol and thymol against Escherichia coli.Aug 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lett Appl Microbiol. 2008 Sep ;47(3):174-9. PMID: 19552781
Article Published Date : Aug 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Escherichia coli Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

These results confirm that thymol may have antiproliferative potential against brain tumor cells involving oxidative alteration.Dec 31, 2016

Pubmed Data : Cent Nerv Syst Agents Med Chem. 2017 ;17(2):116-122. PMID: 27554922
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Brain Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

This study provided the evidence regarding the protective effects of carvacrol and thymol against Aβ25–35-induced cytotoxicity in PC12 cells.Dec 31, 2019

Pubmed Data : Iran Biomed J. 2020 07 ;24(4):243-50. Epub 2020 Jan 22. PMID: 32306722
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Thymol alleviates LPS-induced liver inflammation and apoptosis by inhibiting NLRP3 inflammasome activation.Jul 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Jul 8 ;14(14). Epub 2022 Jul 8. PMID: 35889766
Article Published Date : Jul 07, 2022
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymol ameliorates inflammatory response and accelerates regeneration in cardiotoxin-induced muscle injury.Jan 27, 2016

Pubmed Data : J Pharm Pharmacol. 2016 Jan 28. Epub 2016 Jan 28. PMID: 26817998
Article Published Date : Jan 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
[+]

Thymol and carvacrol downregulate the expression of Salmonella typhimurium virulence genes.Jun 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microorganisms. 2020 Jun 7 ;8(6). Epub 2020 Jun 7. PMID: 32517327
Article Published Date : Jun 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Salmonella Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Thymol and carvacrol protected against acetaminophen induced toxicity.Jan 21, 2016

Pubmed Data : Hum Exp Toxicol. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801986
Article Published Date : Jan 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Dose Response
Problem Substances : Acetaminophen, Paracetamol
[+]

Thymol as a reciprocal regulator of T cell differentiation: Promotion of regulatory T cells and suppression of Th1/Th17 cells.Jan 31, 2019

Pubmed Data : Int Immunopharmacol. 2019 Feb ;67:417-426. Epub 2018 Dec 31. PMID: 30586665
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Immune Dysregulation: TH17 over-expression, Immune Dysregulation: TH1 dominance
Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation
[+]

Thymol at low concentrations provides antioxidative protection to WS-1 cells, while already inducing toxic effects in gastric adenocarcinoma cells.Jul 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Jul 17 ;25(14). Epub 2020 Jul 17. PMID: 32709059
Article Published Date : Jul 16, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Gastric Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic
[+]

Thymol could be a useful therapeutic agent for the prevention of bone destructive diseases.Jul 22, 2018

Pubmed Data : Food Chem Toxicol. 2018 Jul 23 ;120:418-429. Epub 2018 Jul 23. PMID: 30048646
Article Published Date : Jul 22, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Osteoporosis
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor, Osteoprotective
[+]

Thymol elicits HCT-116 colorectal carcinoma cell death through induction of oxidative stress.Mar 26, 2017

Pubmed Data : Anticancer Agents Med Chem. 2017 Mar 27. Epub 2017 Mar 27. PMID: 28356011
Article Published Date : Mar 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Colorectal Cancer
Pharmacological Actions : Cytotoxicity
[+]

Thymol had anti-inflammatory and anti-oxidative effects against LPS-induced acute lung injury.Dec 24, 2017

Pubmed Data : Microb Pathog. 2017 Dec 25 ;116:8-12. Epub 2017 Dec 25. PMID: 29284133
Article Published Date : Dec 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymol increases sensitivity of clinical Col-R gram-negative bacteria to colistin.Jun 13, 2022

Pubmed Data : Microbiol Spectr. 2022 Jun 14:e0018422. Epub 2022 Jun 14. PMID: 35700133
Article Published Date : Jun 13, 2022
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Gram-Negative Bacterial Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Thymol induced Ca²⁺-dissociated cell death in prostate cancer.Jan 27, 2017

Pubmed Data : Chin J Physiol. 2017 02 28 ;60(1):32-40. PMID: 28052644
Article Published Date : Jan 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Prostate Cancer
Pharmacological Actions : Cytotoxicity
[+]

Thymol induces conidial apoptosis in Aspergillus flavus. Aug 14, 2018

Pubmed Data : J Agric Food Chem. 2018 Aug 15 ;66(32):8530-8536. Epub 2018 Aug 6. PMID: 30044621
Article Published Date : Aug 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Fungal Infection
Pharmacological Actions : Antifungal Agents
[+]

Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells.Oct 22, 2020

Pubmed Data : Pharmacol Rep. 2020 Oct 23. Epub 2020 Oct 23. PMID: 33095436
Article Published Date : Oct 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Thymol inhibits bladder cancer cell proliferation via inducing cell cycle arrest and apoptosis.Apr 03, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Apr 4. Epub 2017 Apr 4. PMID: 28389245
Article Published Date : Apr 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Thymol may be explored as a potentially promising food additive for prevention of obesity.Jul 17, 2016

Pubmed Data : Eur J Nutr. 2016 Jul 18. Epub 2016 Jul 18. PMID: 27431894
Article Published Date : Jul 17, 2016
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation
[+]

Thymol mediates bactericidal activity against Staphylococcus aureus by targeting an aldo-keto reductase and consequent depletion of NADPH.Jul 30, 2019

Pubmed Data : J Agric Food Chem. 2019 Jul 31 ;67(30):8382-8392. Epub 2019 Jul 17. PMID: 31271032
Article Published Date : Jul 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Thymol protects against Aspergillus fumigatus keratitis by inhibiting the LOX-1/IL-1β signaling pathway.Mar 14, 2022

Pubmed Data : Curr Med Sci. 2022 Mar 15. Epub 2022 Mar 15. PMID: 35292873
Article Published Date : Mar 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Aspergillosis, Keratitis
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Thymol reduces agr-mediated virulence factor phenol-soluble modulin production in Staphylococcus aureus.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:8221622. Epub 2022 May 9. PMID: 35586806
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Thymol seems to be a promising candidate for topical therapeutic application as antiviral agent for treatment of herpetic infections.Aug 29, 2017

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2017 Aug 30 ;63(8):42-47. Epub 2017 Aug 30. PMID: 28886313
Article Published Date : Aug 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Antiviral Agents
Additional Keywords : Essential Oils
[+]

Thymol targets multiple Salmonella typhimurium virulence factors for lon protease degradation.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:674955. Epub 2021 Aug 26. PMID: 34512322
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymol
Diseases : Salmonella Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Thymol, a major constituent of thyme, protects against gamma ray-induced genotoxicity. Aug 01, 1992

Pubmed Data : J Dairy Sci. 1992 Aug;75(8):2205-14. PMID: 21147817
Article Published Date : Aug 01, 1992
Study Type : In Vitro Study
Additional Links
Substances : Thyme, Thymol
Diseases : DNA damage, Radiation Induced Illness
Pharmacological Actions : Genoprotective, Radioprotective
[+]

Thymus vulgaris and thymol assist murine macrophages in the control of in vitro infections.Jul 31, 2017

Pubmed Data : Immunol Res. 2017 Aug ;65(4):932-943. PMID: 28752199
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thyme, Thymol
Diseases : Candida Albicans, Pseudomonas aeruginosa, Staphylococcus aureus infection
Pharmacological Actions : Immunomodulatory
[+]

Thymus vulgaris, a natural pharmacy against COVID-19: A molecular review.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Herb Med. 2023 Mar ;38:100635. Epub 2023 Jan 26. PMID: 36718131
Article Published Date : Feb 28, 2023
Study Type : Review
Additional Links
Substances : Carvacrol, Thyme, Thymol
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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