Thymoquinone

Name	AC	CK
Oxidative Stress	30	57
Breast Cancer	28	40
Diabetes Mellitus: Type 2	8	39
Inflammation	19	31
Cancers: All	29	30
Chemotherapy-Induced Toxicity: Cisplatin	10	19
Alzheimer's Disease	10	18
Liver Cancer	14	18
Ischemia	9	16
Neurodegenerative Diseases	13	16
Brain Inflammation	8	13
Lipid Peroxidation	7	13
Parkinson's Disease	10	13
Periodontitis	3	13
Sepsis	7	13
Chemically-Induced Liver Damage	6	12
Kidney Damage: Chemically-Induced	6	12
Myocardial Ischemia	6	12
Nonalcoholic fatty liver disease (NAFLD)	2	12
Kidney Damage	7	11
Rheumatoid Arthritis	6	11
Chemotherapy-Induced Toxicity: Doxorubicin	5	10
Lead Poisoning	5	10
Lipopolysaccharide-Induced Toxicity	6	10
Liver Damage	6	10
Testicular Injury: Chemical/Metal Induced	5	10
Colon Cancer	6	9
Pancreatic Cancer	5	9
Asthma	6	8
Brain: Oxidative Stress	4	8
Breast Cancer: Triple Negative	7	8
Cerebral Ischemia	4	8
Diabetic Complications	5	8
Kidney Cancer	8	8
Prostate Cancer	7	8
Cervical Cancer	6	7
Colorectal Cancer	6	7
Depression	4	7
Glioblastoma	3	7
Obesity	4	7
Alcohol Toxicity	3	6
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	6
Gastric Cancer	4	6
Glioblastoma Multiforme	2	6
Hydrogen Peroxide Induced Toxicity	2	6
Hypercholesterolemia	3	6
Hypertension	3	6
Insulin Resistance	3	6
Liver Injury: Ischemia/reperfusion	3	6
Polycystic Ovary Syndrome	3	6
Psoriasis	4	6
Acrylamide-induced toxicity	3	5
Arsenic Poisoning	3	5
Diabetic Nephropathy	3	5
Epilepsy	4	5
Kidney Diseases	3	5
Melanoma	4	5
Mycobacterium tuberculosis	1	5
Osteoarthritis	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Atherosclerosis	2	4
Bladder Cancer	3	4
Cancer Metastasis	3	4
Cardiovascular Diseases	3	4
Chemotherapy and Radiation Toxicity	2	4
Chemotherapy-Induced Toxicity: Gentamicin	2	4
Coronavirus Infection	4	4
DNA damage	2	4
Diabetes: Oxidative Stress	2	4
Drug Toxicity: Methotrexate	2	4
Escherichia coli Infections	3	4
Esophageal Cancer	2	4
Hyperlipidemia	2	4
Infertility: Male	2	4
Intestinal Ischemia	2	4
Leukemia	3	4
Lung Cancer	4	4
Memory Disorders	3	4
Nephropathy	2	4
Oral Cancer	3	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Radiotherapy	2	4
Spinal Cord Injuries	2	4
Staphylococcus aureus infection	4	4
Traumatic Brain Injury	3	4
Wound Healing	3	4
Acute lymphoblastic leukemia (ALL)	3	3
Allergies	3	3
Anxiety	2	3
Bacterial Infections	2	3
Brain Ischemia	2	3
Cancers: Drug Resistant	3	3
Candida Albicans	2	3
Gastric Ulcer	2	3
Hyperglycemia	2	3
Hyperuricemia	2	3
Lung Injury: Smoke-Induced	2	3
Mitochondrial Dysfunction	2	3
Multiple Myeloma	2	3
Ovarian Cancer	3	3
Pain	2	3
Squamous cell carcinoma	2	3
Air Pollution Linked Toxicity	1	2
Alcohol Addiction	1	2
Alcoholism	1	2
Allergic Rhinitis	1	2
Aluminum Toxicity	1	2
Antibiotic Toxicity	1	2
Arthritis	1	2
Atopic Dermatitis	1	2
Avian Influenza	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Bisphenol Toxicity	1	2
Bisphenol-A Toxicity	1	2
Brain Cancer	2	2
Brain Damage	1	2
Breast Cancer: Chemically-Induced	1	2
Breast Cancer: Prevention	1	2
Cadmium Poisoning	1	2
Cancers: Radiation-Induced	1	2
Cardiac Arrhythmias	1	2
Cardiomyopathy	1	2
Cataract: Radiation-Induced	1	2
Cerebral Hypoperfusion	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Kidney	1	2
Cholestasis	1	2
Dementia	1	2
Diabetes Mellitus: Type 2: Prevention	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Kidney Function	1	2
Diabetic Neuropathies	1	2
Diabetic Neuropathy	1	2
Diesel Exhaust Particle Toxicity	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Ehrlich carcinoma	1	2
Endotoxemia	1	2
Epilepsy: Drug-Induced	1	2
Facial Nerve Diseases	1	2
Facial Paralysis	1	2
Fibrosis: Liver	1	2
Fluoride Toxicity	1	2
Formaldehyde Toxicity	1	2
Gastric Ulcers	1	2
Glaucoma	1	2
Glioma	2	2
Gram-Negative Bacterial Infections	2	2
Gram-Positive Bacterial Infections	2	2
HIV Drug-Induced Toxicity	1	2
Headache: Migraine	1	2
Heavy Metal Toxicity	1	2
Herbicide Toxicity	1	2
High Cholesterol	1	2
High Fat Diet	1	2
High Fructose Diet	1	2
High Homocysteine	1	2
Huntington Disease	1	2
Hyperbilirubinemia: Hereditary	1	2
Hypothyroidism	1	2
Infertility	1	2
Inflammatory Bowel Diseases	1	2
Influenza A	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Fibrosis	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Disease	1	2
Liver Fibrosis	1	2
Lung Diseases	2	2
Manganese Poisoning	1	2
Metabolic Diseases	1	2
Morphine Tolerance/Dependence	1	2
Myocardial Fibrosis	1	2
Myocardial Infarction	1	2
Myocardial Necrosis	1	2
NSAID-induced toxicity	1	2
Nerve Compression Syndromes	1	2
Neuroblastoma	2	2
Osteoporosis	1	2
Osteosarcoma	2	2
Otitis	1	2
Pancreatic Cancer: Metastatic	1	2
Pancreatitis	1	2
Parasitic Diseases	1	2
Peripheral Nerve Diseases	1	2
Pesticide Toxicity	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Prostatic Hyperplasia: Benign	1	2
Pseudomonas aeruginosa	2	2
Pulmonary Fibrosis	1	2
Radiation Induced Illness: Enteritis	1	2
Seizures	1	2
Sodium nitrate toxicity	1	2
Sperm Quality: Low	1	2
Statin-Induced Pathologies	1	2
Subarachnoid hemorrhage	1	2
Titanium Toxicity	1	2
Triglycerides: Elevated	1	2
Acute Myeloid Leukemia	1	1
Advanced Glycation End products (AGE)	1	1
Aflatoxicosis	1	1
Autoimmune Diseases	1	1
Bacillus subtilis infections	1	1
Breast Cancer: Bone Metastasis	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Glabrata	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Central Nervous System Diseases	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clostridium Infections	1	1
Colitis	1	1
Cough	1	1
Denture Stomatitis	1	1
Diabetes	1	1
Diabetes: Reproductive	1	1
Diarrhea: Bacterial	1	1
Dyslipidemias	1	1
Encephalomyelitis	1	1
Fibrosis	1	1
Glial Cell Tumors	1	1
Head and Neck Cancer	1	1
Hodgkin Lymphoma	1	1
Hypersensitivity: Respiratory	1	1
IgE-Mediated Hypersensitivity	1	1
Klebsiella Infections	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lewy Body Parkinson Disease	1	1
Listeria Infections	1	1
Liver Cancer: Hepatitis B Associated	1	1
Liver Diseases	1	1
Lower Respiratory Infections	1	1
Lung Injury: Acute	1	1
Lymphoma	1	1
Macular Degeneration	1	1
Malignant Melanoma	1	1
Medulloblastoma	1	1
Nephrolithiasis	1	1
Neurological Conditions	1	1
Opiate Addiction/Withdrawal	1	1
Opioid Tolerance/Dependence	1	1
Periodontal Diseases	1	1
Porphyromonas gingivalis	1	1
Schizophrenia	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Staphylococcus epidermidis	1	1
Stomach Cancer	1	1
Stroke	1	1
Thrombosis	1	1
Thyroid Cancer	1	1
Vibrio parahaemolyticus	1	1

Name	AC	CK
Antioxidants	122	219
Anti-Inflammatory Agents	109	191
Neuroprotective Agents	60	105
Apoptotic	79	104
Antiproliferative	57	72
Tumor Necrosis Factor (TNF) Alpha Inhibitor	32	68
Hepatoprotective	30	63
Renoprotective	33	61
Interleukin-6 Downregulation	23	54
NF-kappaB Inhibitor	32	50
Anti-Apoptotic	28	49
Anti-metastatic	36	45
Chemoprotective Agents	24	43
Cardioprotective	21	40
Hypoglycemic Agents	6	37
Chemotherapeutic	26	34
Interleukin-1 beta downregulation	13	24
Chemopreventive	17	22
Antimicrobial	9	19
Anticarcinogenic Agents	12	18
Cell cycle arrest	11	18
Chemosensitizer	11	17
Anti-Bacterial Agents	11	16
Cyclooxygenase 2 Inhibitors	9	16
Nitric Oxide Inhibitor	7	16
Nrf2 activation	10	16
Superoxide Dismutase Up-regulation	8	16
Immunomodulatory	11	15
Bcl-2 protein down-regulation	8	14
Malondialdehyde Down-regulation	7	14
Radioprotective	7	14
Gastroprotective	7	13
Antineoplastic Agents	8	12
Tumor Suppressor Protein p53 Upregulation	7	12
Anti-Fibrotic	6	11
Vascular Endothelial Growth Factor Inhibitors	7	11
Cytoprotective	6	10
Angiogenesis Inhibitors	5	8
Anti-Angiogenic	3	8
Heme oxygenase-1 up-regulation	5	8
P21 Activation	4	8
Antiviral Agents	6	7
MicroRNA modulator	5	7
Anti-Ulcer Agents	3	6
Antihypertensive Agents	3	6
Hypolipidemic	3	6
Radiosensitizer	4	6
Telomerase Inhibitor	2	6
Antidepressive Agents	3	5
Autophagy Up-regulation	4	5
Histone deacetylase inhibitor	1	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	5	5
STAT3 Inhibitor	3	5
Interleukin-18 down-regulation	2	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	4
Regenerative	2	4
Vascular Endothelial Growth Factor A Inhibitor	3	4
Anti-Asthmatic Agents	2	3
Antinoceceptive	2	3
Antiparasitic Agents	2	3
Autophagy Inhibitors	3	3
Genoprotective	2	3
Interleukin-2 Downregulation	2	3
Pancreato Protective Agents	2	3
5-Lipoxygenase Inhibitor	1	2
Anti-Allergic Agents	2	2
Anti-Anxiety Agents	1	2
Anticonvulsants	1	2
Antifungal Agents	2	2
Antimutagenic Agents	1	2
Catalase Up-Regulation	1	2
Chemotherapeuticm	1	2
Cytotoxic	2	2
Fertility Agents: Male	1	2
GABA Modulators	1	2
Gastrointestinal Agents	2	2
Glutathione Upregulation	1	2
Insulin-releasing	1	2
Interferon Gamma Reducer	1	2
Interferon-gamma (IFN-gamma) inducer	1	2
Interleukin-1 alpha downregulation	1	2
Interleukin-10 downregulation	1	2
Interleukin-10 upregulation	1	2
Neurogenesis	1	2
Prostaglandin PGE2 downregulation	1	2
Vasodilator Agents	1	2
Wnt/β-catenin signaling pathway modulation	1	2
Analgesics	1	1
Anticoagulants	1	1
Antitussive Agents	1	1
Bcl-xL down-regulation	1	1
Enzyme Activators	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Immunostimulatory	1	1
Interleukin-8 downregulation	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Phase II Detoxification Enzyme Inducer	1	1
Postaglandin PGE2 downregulation	1	1
Quorum Sensing Inhibition	1	1
Wnt/β-catenin pathway down-regulation	1	1
Xanthine oxidase inhibitor	1	1

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Braz J Cardiovasc Surg. 2022 Jun 3. Epub 2022 Jun 3. PMID: 35657313

Article Published Date : Jun 02, 2022

Study Type : Animal Study

Additional Links

Substances : Curcumin, Silymarin, Thymoquinone

Diseases : Ischemia

Pharmacological Actions : Antioxidants

[+]

Antioxidant and anti-inflammatory potential of thymoquinone and lycopene mitigate the chlorpyrifos-induced toxic neuropathy.Sep 19, 2021

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Problem Substances : Methotrexate

[+]

Evaluation of results supported the beneficial effects of thymoquinone in renal injury produced by rheumatoid arthritis.Jul 31, 2015

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Pubmed Data : J Coll Physicians Surg Pak. 2015 Aug ;25(8):597-601. PMID: 26305307

Article Published Date : Jul 31, 2015

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Pubmed Data : J Inflamm Res. 2022 ;15:2263-2280. Epub 2022 Apr 8. PMID: 35422652

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Pubmed Data : Pharmaceuticals (Basel). 2022 Aug 17 ;15(8). Epub 2022 Aug 17. PMID: 36015156

Article Published Date : Aug 16, 2022

Study Type : Animal Study

Additional Links

Substances : Thymol, Thymoquinone

Diseases : Aluminum Toxicity , Alzheimer's Disease

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

Problem Substances : Aluminum Chloride

[+]

Nigella sativa and its main constituent, thymoquinone protect against glycerol-induced acute kidney injury.Dec 31, 2021

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Nigella sativa oil and thymoquinone may have protective effects during cerebral ischemia-reperfusion injury.Aug 31, 2007

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Pubmed Data : Phytomedicine. 2007 Sep ;14(9):621-7. Epub 2007 Feb 8. PMID: 17291733

Article Published Date : Aug 31, 2007

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Cerebral Ischemia, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Phytotherapy

[+]

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.Jan 03, 2018

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2018 Jan 4. Epub 2018 Jan 4. PMID: 29302711

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Protective effect of thymoquinone against diazinon-induced hematotoxicity, genotoxicity and immunotoxicity in rats.Sep 30, 2017

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Pubmed Data : Environ Toxicol Pharmacol. 2017 Oct ;55:217-222. Epub 2017 Sep 7. PMID: 28938193

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Pharmacological Actions : Hepatoprotective

[+]

Protective effect of thymoquinone against lung intoxication induced by malathion inhalation.Jan 27, 2021

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Pubmed Data : Sci Rep. 2021 Jan 28 ;11(1):2498. Epub 2021 Jan 28. PMID: 33510276

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Sep 29. Epub 2020 Sep 29. PMID: 32989703

Article Published Date : Sep 28, 2020

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Arsenic Poisoning, Liver Damage

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Hepatoprotective

Problem Substances : Arsenic

[+]

Protective role of thymoquinone against paraquat-induced hepatotoxicity in mice.May 31, 2018

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Pubmed Data : Pestic Biochem Physiol. 2018 Jun ;148:16-21. Epub 2018 Mar 13. PMID: 29891368

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Pubmed Data : Head Neck. 2017 Jul 14. Epub 2017 Jul 14. PMID: 28708300

Article Published Date : Jul 13, 2017

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Antioxidants, Radioprotective

[+]

Click here to read the entire abstract

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Pubmed Data : Clin Exp Otorhinolaryngol. 2015 Dec ;8(4):312-9. Epub 2015 Nov 10. PMID: 26622947

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Antibiotic Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Antibiotics

[+]

The present study conclude that thymoquinone reduced acute endoxemia-induced liver dysfunction.Mar 31, 2010

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Pubmed Data : Pak J Pharm Sci. 2010 Apr ;23(2):131-7. PMID: 20363688

Article Published Date : Mar 31, 2010

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

The protective effect of thymoquinone or/and thymol against monosodium glutamate-induced attention-deficit/hyperactivity disorder.Oct 31, 2022

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Pubmed Data : Biomed Pharmacother. 2022 Nov ;155:113799. Epub 2022 Oct 6. PMID: 36271575

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Med Ther. 2022 Dec 5 ;22(1):321. Epub 2022 Dec 5. PMID: 36464690

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2017 Feb 20 ;7:42995. Epub 2017 Feb 20. PMID: 28216638

Pubmed Data : Eur J Nutr. 2015 Oct ;54(7):1117-27. Epub 2014 Oct 28. PMID: 25347965

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Pubmed Data : Biomed Pharmacother. 2018 Jan 20 ;99:391-401. Epub 2018 Jan 20. PMID: 29367108

Article Published Date : Jan 19, 2018

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Alzheimer's Disease, Diabetes: Cognitive Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Thymoquinone administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta ischemia-reperfusion rat model.Dec 31, 2014

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Pubmed Data : Rev Bras Cir Cardiovasc. 2015 Jan-Mar;30(1):77-83. PMID: 25859871

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Ischemia, Liver Injury: Ischemia/reperfusion , Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

[+]

Thymoquinone ameliorates acrylamide-induced reproductive toxicity in female rats.Dec 31, 2022

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Pubmed Data : Int J Reprod Biomed. 2023 Jan ;21(1):61-70. Epub 2023 Feb 8. PMID: 36875499

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Acrylamide-induced toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors

[+]

Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats.Jul 29, 2013

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Pubmed Data : PMID: 23910425

Article Published Date : Jul 29, 2013

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Brain Damage, Heavy Metal Toxicity, Lead Poisoning

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Lead

[+]

Thymoquinone ameliorates lung inflammation and pathological changes observed in lipopolysaccharide-induced lung injury.Dec 31, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2019 May 2. Epub 2019 May 2. PMID: 31044379

Article Published Date : May 01, 2019

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Escherichia coli Infections, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats.Mar 13, 2017

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Pubmed Data : Pharmacol Rep. 2017 Mar 14 ;69(4):648-657. Epub 2017 Mar 14. PMID: 28521173

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Pubmed Data : Arch Med Sci. 2015 Mar 16 ;11(1):220-9. Epub 2013 Feb 28. PMID: 25861310

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Pubmed Data : Int J Mol Sci. 2021 Jun 25 ;22(13). Epub 2021 Jun 25. PMID: 34202112

Article Published Date : Jun 24, 2021

Study Type : Animal Study

Additional Links

Substances : Curcumin, Thymoquinone

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective, Neuroprotective Agents

[+]

Thymoquinone and curcumin significantly enhanced immune responsiveness and suppress pathogenicity of influenza viruses in turkeys.Mar 03, 2016

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Pubmed Data : Poult Sci. 2016 Mar 4. Epub 2016 Mar 4. PMID: 26944958

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Pubmed Data : Arch Physiol Biochem. 2022 Oct 20:1-14. Epub 2022 Oct 20. PMID: 36264662

Article Published Date : Oct 19, 2022

Study Type : Animal Study

Additional Links

Substances : Quercetin, Thymoquinone

Diseases : Hepatic Steatosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, SIRT1 Activator

[+]

Thymoquinone and resveratrol can work synergistically against breast cancer in mice.Mar 31, 2017

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Pubmed Data : Asian Pac J Trop Med. 2017 Apr ;10(4):400-408. Epub 2017 Apr 7. PMID: 28552110

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Pubmed Data : Oncotarget. 2014 Feb 15 ;5(3):634-48. PMID: 24504138

Article Published Date : Feb 14, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Thymoquinone can have a new treatment option to ameliorate the nerve injury.May 23, 2016

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Pubmed Data : Am J Otolaryngol. 2016 May 24. Epub 2016 May 24. PMID: 27311344

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Kidney Dis. 2017 Mar ;11(2):142-150. PMID: 28270647

Article Published Date : Feb 28, 2017

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Nitric Oxide Inhibitor, Renoprotective

Problem Substances : Morphine

[+]

Thymoquinone counteracts oxidative and inflammatory machinery in carrageenan-induced murine paw edema model.Oct 02, 2022

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[+]

Thymoquinone exhibits a regenerative potential for the treatment of damaged peripheral nerves.Aug 07, 2018

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Pubmed Data : Neurol Res. 2018 Aug 8:1-8. Epub 2018 Aug 8. PMID: 30088803

Article Published Date : Aug 07, 2018

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Peripheral Nerve Diseases

Pharmacological Actions : Neuroprotective Agents, Regenerative

Additional Keywords : Nerve Regeneration

[+]

Thymoquinone exhibits an important protective effect against ischemia-reperfusion injury of the spinal cord.Feb 11, 2016

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Pubmed Data : J Neurosurg Spine. 2016 Feb 12:1-11. Epub 2016 Feb 12. PMID: 26871652

Article Published Date : Feb 11, 2016

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Ischemia, Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

[+]

Thymoquinone exhibits anti-proliferative, apoptotic and anti-invasive properties in a cervical cancer cell line.Oct 31, 2013

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Pubmed Data :

Mol Cell Biochem. 2013 Nov;383(1-2):243-51. doi: 10.1007/s11010-013-1772-x. Epub 2013 Aug 14.PMID: 23943306

Thymoquinone has a protective role with optimum dose of 9 mg/kg in Aflatoxin B1 hepatotoxicity.Dec 31, 2010

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Pubmed Data : Daru. 2011 ;19(4):282-7. PMID: 22615670

Article Published Date : Dec 31, 2010

Study Type : Animal Study

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Substances : Thymoquinone

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective

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Additional Keywords : Gene Expression Regulation

Problem Substances : Pesticides

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Thymoquinone holds potential for neuroprotection and may be a promising approach for the treatment of neurodegenerative disorders.Mar 31, 2018

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Pubmed Data : Neurol Res. 2018 Apr ;40(4):324-333. Epub 2018 Feb 21. PMID: 29464986

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Pubmed Data : Int J Health Sci (Qassim). 2008 Jan ;2(1):15-25. PMID: 21475467

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Pubmed Data : 2013 Oct 23;223(1):60-72. doi: 10.1016/j.toxlet.2013.08.018. Epub 2013 Sep 3. PMID:24012840

Article Published Date : Oct 22, 2013

Study Type : Animal Study

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Substances : Thymoquinone

Diseases : Liver Cancer

Pharmacological Actions : Cell cycle arrest, Chemopreventive

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Thymoquinone inhibits LoVo cancer cell growth and migration.Feb 20, 2017

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Pubmed Data : World J Gastroenterol. 2017 Feb 21 ;23(7):1171-1179. PMID: 28275297

Thymoquinone is a promising prophylactic agent against chemical carcinogenesis and toxicity.Aug 31, 2009

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Pubmed Data : Phytother Res. 2009 Sep ;23(9):1295-8. PMID: 19277968

Article Published Date : Aug 31, 2009

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents

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Thymoquinone is effective in protecting rats against l-NAME-induced hypertension and renal damage.Apr 30, 2007

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Pubmed Data : Phytother Res. 2007 May ;21(5):410-4. PMID: 17236176

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Pubmed Data : Biomed Res Int. 2020 ;2020:1594726. Epub 2020 Jun 16. PMID: 32626733

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Pubmed Data : Mediators Inflamm. 2015 ;2015:859383. Epub 2015 May 21. PMID: 26089605

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Drug-Induced Toxicity: Methotrexate

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective

[+]

Thymoquinone may be considered for topical application alone in the treatment of acute otitis externa.Dec 13, 2017

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Pubmed Data : J Int Adv Otol. 2017 Dec 14. Epub 2017 Dec 14. PMID: 29283096

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:143629. Epub 2015 May 25. PMID: 26101531

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances :

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View the Evidence: 644 Abstracts with Thymoquinone Research

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The antidiabetic effect of thymoquinone: A systematic review and meta-analysis of animal studies.Dec 31, 2019

Thymoquinone plus immunotherapy in extra-pulmonary neuroendocrine carcinoma.Nov 20, 2022

Application of 0.2% Thymoquinone gel could be a beneficial adjunct in treating chronic periodontitis.Sep 30, 2018

Nigella sativa seed oil supplements may decrease the liver enzymes and lipid profiles in the patients with NAFLD.Nov 30, 2019

Thymoquinone with metformin decreases fasting, post prandial glucose, and HbA1c in type 2 diabetic patients.Mar 07, 2021

Nanoparticular thymoquinone attenuates angiogenesis and metastasis of triple-negative breast cancer.Mar 31, 2020

Thymoquinone antifungal activity against Candida glabrata.Apr 20, 2023

Thymoquinone could be useful as a potential chemotherapeutic agent in the management for brain tumours.Aug 11, 2010

Thymoquinone holds a neuroprotective potential and could be a promising therapeutic agent to reduce the risk of developing Alzheimer's disease.Feb 28, 2019

Thymoquinone inhibited IL-1β-induced inflammatory mediator production by inhibition of NF-κB and MAPKs signaling pathways in osteoarthritis chondrocytes.Jul 08, 2015

Thymoquinone intensified temozolomide-induced apoptosis in U87MG cells.Apr 20, 2017

Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.Dec 31, 2015

Thymoquinone represents a prospective treatment option to combat Mycobacterium tuberculosis infection.May 24, 2017

Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.Dec 31, 2015

Low concentration of thymoquinone enhances the inhibitory effects of 5-FU on cell growth in colorectal cancer cell line.Dec 31, 2021

Thymoquinone has anti-inflammatory effects and may be a potential nutraceutical candidate for the prevention and treatment of atherosclerosis.Apr 14, 2022

Thymoquinone-loaded essential oil-based emulgel as an armament for anti-psoriatic activity.Dec 21, 2022

Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice.Nov 23, 2021

"Anti-metastasis effect of thymoquinone on human pancreatic cancer"Jul 31, 2011

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

A study of antibacterial effect of Nigella sativa seed extracts on bacterial isolates from cases of wound infection.Apr 02, 2023

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.Nov 30, 2017

Alpha-tocopherol and thymoquinone may strongly protect muscle and nerve tissues against ischemia-reperfusion injury.Feb 29, 2016

Ameliorative effect of thymoquinone-loaded PLGA nanoparticles on chronic lung injury induced by repetitive intratracheal instillation of lipopolysaccharide.Dec 31, 2020

Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity.May 31, 2018

An ethanolic extract of Nigella sativa seeds exhibits antipsoriatic activity. Sep 30, 2012

Antimicrobial, immunomodulatory and anti-Inflammatory potential of liposomal thymoquinone.Nov 11, 2021

Antinociceptive action of thymoquinone-loaded liposomes in an in vivo model of tendinopathy.May 16, 2023

Antioxidant actions of thymoquinone, silymarin, and curcumin on experimental aortic ischemia-reperfusion.Jun 02, 2022

Antioxidant and anti-inflammatory potential of thymoquinone and lycopene mitigate the chlorpyrifos-induced toxic neuropathy.Sep 19, 2021

antioxidant effect of thymoquinone could protect damage of liver parameters against morphine toxicity.Dec 31, 2017

Antioxidants inhibit neuronal toxicity in leucine-rich repeat kinase-2-linked Parkinson's disease. Mar 31, 2016

Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats.Dec 31, 2017

Berbamine and thymoquinone exert protective effects against immune-mediated liver injury.Dec 31, 2021

Black seed thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin-induced diabetic male wistar rats.Dec 31, 2017

Both Nigella sativa and thymoquinone can partly protect gastric mucosa from acute alcohol-induced mucosal injury.Nov 13, 2005

Both Nigella sativa oil and thymoquinone possess gastroprotective effect against gastric lesions.Jan 31, 2003

Both propolis and thymoquinone diminished the risk of atherosclerosis via antioxidant mechanisms.Mar 31, 2010

Cardioprotective effects of co-administration of thymoquinone and ischemic postconditioning in diabetic rats.Jun 30, 2021

Celastrol and thymoquinone alleviate aluminum chloride-induced neurotoxicity.May 12, 2022

Chemopreventive efficacy of thymoquinone in chemically induced urinary bladder carcinogenesis.Dec 31, 2021

Chronic administration of thymoquinone enhances adult hippocampal neurogenesis and improves memory.Dec 01, 2021

Cold-pressed Nigella Sativa oil standardized to 3% thymoquinone potentiates omega-3 protection against obesity.Jun 03, 2020

Comparison of the effects of thymoquinone and silymarin on the brain of rats having ischemia-reperfusion in the lower extremities.Nov 18, 2019

Daily intake of thymoquione after and before or during exposure to B(a)P significantly reduced the rates of chromosomal aberrations and damaged cells.Dec 31, 2006

Dietary thymoquinone alone or combined with swimming exercise protect against microcystin-LR-induced oxidative injury.Dec 31, 2022

Effect of thymoquinone on renal damage induced by hyperlipidemia.Dec 31, 2021

Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue.Apr 04, 2021

Effects of thymoquinone alone or in combination with losartan on the cardiotoxicity caused by oxidative stress and inflammation in hypercholesterolemia. Nov 30, 2022

Effects of thymoquinone in prevention of experimental contrast-induced nephropathy.Nov 30, 2019

Effects of Thymoquinone on radiation enteritis in mice.Oct 10, 2018

Effects of thymoquinone on scopolamine-induced spatial and echoic memory changes through regulation of lipid peroxidation and cholinergic impairment.Jun 15, 2022

Effects of thymoquinone on small-molecule metabolites in a rat model of cerebral ischemia reperfusion injury.Jan 06, 2020

Effects of thymoquinone on spinal cord injury.Nov 30, 2022

Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone.Sep 06, 2017

Evaluation of data supported the anti-inflammatory activities of thymoquinone, so it may be investigated as an effective anti-inflammatory drug in rheumatoid arthritis.Apr 30, 2015

Evaluation of results supported the beneficial effects of thymoquinone in renal injury produced by rheumatoid arthritis.Jul 31, 2015

Evaluation of the radioprotective effects of thymoquinone on dynamic thiol-disulphide homeostasis during total-body irradiation.Oct 23, 2018

Exosomal miR-687 inhibition by thymoquinone protected both renal and hepatic tissues from injury.Oct 10, 2021

Experimental and theoretical insights on chemopreventive effect of the liposomal thymoquinone against benzo[ a]pyrene-induced lung cancer.Dec 31, 2021

Exploring the possible mitoprotective and neuroprotective potency of thymoquinone, betanin, and vitamin D against cytarabine-induced mitochondrial impairment and neurotoxicity.Nov 22, 2022

Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats.Jul 18, 2021

Immunomodulatory effect of thymoquinone on atopic dermatitis.Jul 17, 2018

Impact of zinc oxide nanoparticles and thymoquinone in Ehrlich ascites carcinoma.Jan 28, 2021

Improved chemotherapeutic efficacy against human breast cancer cells with co-delivery of docetaxel and thymoquinone by chitosan grafted lipid nanocapsules.Oct 22, 2019

Increased glucose and HbA1c levels and the indicators of liver and kidney damages were decreased significantly after thymoquinone supplementation.Sep 30, 2017

Melatonin and thymoquinone protect against IR-induced injury to intestinal tissues.Aug 31, 2015

Methanolic extracts and volatile oil extracts of N. sativa seed oil may be used as antioxidant as well as hypolipidemic agentsDec 17, 2015

Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.Nov 12, 2013

N-acetylcysteine and thymoquinone have renoprotective effects of against the toxicity of fluoride via multiple mechanisms.Dec 31, 2017

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.Nov 30, 2010

Thymoquinone

View the Evidence:
644 Abstracts with Thymoquinone Research