Tocotrienols

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37 Diseases Researched for Tocotrienols
NameACCKFocus
Oxidative Stress746Locked
Insulin Resistance212Locked
Cataract110Locked
Cognitive Decline/Dysfunction110Locked
DNA damage110Locked
Dyslipidemias110Locked
Fatty Liver110Locked
Hemodialysis110Locked
Hyperlipidemia110Locked
Osteopenia110Locked
Ultraviolet Radiation Induced Damage110Locked
Skin Cancer15Locked
Obesity34Locked
Aspirin-Induced Toxicity 12Locked
Bone Diseases12Locked
Breast Cancer22Locked
Diabetes Mellitus: Type 1: Prevention12Locked
Diabetes Mellitus: Type 212Locked
Gastric Ulcer12Locked
Kidney Damage12Locked
Lipid Peroxidation12Locked
Liver Cancer12Locked
Osteoporosis12Locked
Prostate Cancer12Locked
Bowel Stenosis11Locked
Cancer Metastasis11Locked
Cervical Cancer11Locked
Chemotherapy-Induced Toxicity: Cisplatin11Locked
Crohn's Disease11Locked
Glioma11Locked
High Cholesterol11Locked
Human Gastric Adenocarcinoma 11Locked
Malignant Melanoma11Locked
Melanoma11Locked
Melanoma: Metastatic11Locked
Mesothelioma11Locked
Neurodegenerative Diseases11Locked
25 Pharmacological Actions Researched for Tocotrienols
NameACCKFocus
Antioxidants1043Locked
Interleukin-6 Downregulation212Locked
Malondialdehyde Down-regulation212Locked
Neuroprotective Agents312Locked
Cyclooxygenase 2 Inhibitors110Locked
Hypolipidemic110Locked
NF-kappaB Inhibitor110Locked
Superoxide Dismutase Up-regulation110Locked
Antineoplastic Agents15Locked
Apoptotic45Locked
Insulin Sensitizers24Locked
Renoprotective24Locked
Anti-Inflammatory Agents22Locked
Anticarcinogenic Agents12Locked
Antioxidant12Locked
Antiproliferative 22Locked
Cell cycle arrest12Locked
Chemopreventive12Locked
Gastroprotective12Locked
Hypoglycemic Agents12Locked
Anti-metastatic11Locked
Chemosensitizer11Locked
Interleukin-6 upregulation11Locked
Osteogenic11Locked
Regenerative11Locked

View the Evidence:
36 Abstracts with Tocotrienols Research

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This meta-analysis revealed that tocotrienol consumption was associated with increase in BW and DBP and decrease in SBP.Apr 27, 2021

Pubmed Data : Crit Rev Food Sci Nutr. 2021 Apr 28:1-14. Epub 2021 Apr 28. PMID: 33909529
Article Published Date : Apr 27, 2021
Study Type : Meta Analysis
Additional Links
Substances : Tocotrienols
Diseases : Hypertension, Obesity
Pharmacological Actions : Antihypertensive Agents
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A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.Mar 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr J. 2015 Mar 28 ;14:30. Epub 2015 Mar 28. PMID: 25886384
Article Published Date : Mar 28, 2015
Study Type : Human Study
Additional Links
Substances : Berberine, Chlorogenic Acid, Tocotrienols
Diseases : Fatty Liver, Hyperlipidemia, Insulin Resistance
Problem Substances : Insulin
[+]

Cognitive function improvement with astaxanthin and tocotrienol intake.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2020 Nov ;67(3):307-316. Epub 2020 Jun 19. PMID: 33293773
Article Published Date : Oct 31, 2020
Study Type : Human Study
Additional Links
Substances : Astaxanthin, Tocotrienols
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats.Jan 01, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(3):e0174542. Epub 2017 Mar 28. PMID: 28350848
Article Published Date : Jan 01, 2017
Study Type : Human Study
Additional Links
Substances : Tocotrienols
Diseases : Cataract, Oxidative Stress
Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation
[+]

Tocotrienols and tocopherols reduce markers of lipid peroxidation.Jan 10, 2017

Pubmed Data : Clin Nutr ESPEN. 2017 10 ;21:1-12. Epub 2017 Jul 29. PMID: 30014863
Article Published Date : Jan 10, 2017
Study Type : Human Study
Additional Links
Substances : Tocopherols, Tocotrienols
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Malondialdehyde Down-regulation
[+]

Tocotrienols attenuate UV-induced inflammaging.Jun 01, 2018

Pubmed Data : J Cosmet Dermatol. 2018 Jun ;17(3):555-565. Epub 2017 Sep 26. PMID: 28952200
Article Published Date : Jun 01, 2018
Study Type : Human Study
Additional Links
Substances : Tocotrienols
Diseases : Oxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation
[+]

Twelve-week annatto-extracted tocotrienol supplementation decreased bone resorption and improved bone turnover rate via suppressing bone remodeling regulators in postmenopausal women with osteopenia.Jan 01, 2018

Pubmed Data : Osteoporos Int. 2018 04 ;29(4):881-891. Epub 2018 Jan 12. PMID: 29330573
Article Published Date : Jan 01, 2018
Study Type : Human Study
Additional Links
Substances : Tocotrienols
Diseases : Osteopenia, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients.Jan 01, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Vasc Health Risk Manag. 2013 ;9:747-61. Epub 2013 Nov 28. PMID: 24348043
Article Published Date : Jan 01, 2013
Study Type : Human Study
Additional Links
Substances : Tocotrienols
Diseases : Dyslipidemias, Hemodialysis
Pharmacological Actions : Hypolipidemic
[+]

This paper describes a tocotrienol nano emulsion with enhanced effectiveness against skin carcinomas.Jun 01, 2016

Pubmed Data : Drug Deliv. 2016 Jun ;23(5):1514-24. Epub 2014 Oct 8. PMID: 25293973
Article Published Date : Jun 01, 2016
Study Type : Human In Vitro
Additional Links
Substances : Tocotrienols
Diseases : Skin Cancer
Pharmacological Actions : Antineoplastic Agents
[+]

A tocotrienol rich fraction of palm oil protects against chemically-induced kidney damage.Jul 30, 2010

Pubmed Data : Chem Biol Interact. 2010 Jul 30;186(2):228-38. Epub 2010 Apr 28. PMID: 20433818
Article Published Date : Jul 30, 2010
Study Type : Animal Study
Additional Links
Substances : Palm Oil, Tocotrienols
Diseases : Kidney Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Mixed tocotrienols inhibit prostate carcinogenesis in mice.Aug 01, 2010

Pubmed Data : Nutr Cancer. 2010 Aug;62(6):789-94. PMID: 20661828
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Tocotrienols
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Cell cycle arrest
[+]

The combination of berberine, tocotrienols and coffee extracts improves metabolic profile and liver steatosis.Apr 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Apr 13 ;13(4). Epub 2021 Apr 13. PMID: 33924725
Article Published Date : Apr 12, 2021
Study Type : Animal Study
Additional Links
Substances : Berberine, Coffee, Tocotrienols
Diseases : Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypolipidemic, MicroRNA modulator
[+]

Tocotrienol offers protection against free radical-induced damage of rat bone. Sep 01, 2005

Pubmed Data : Clin Exp Pharmacol Physiol. 2005 Sep;32(9):761-70. PMID: 16173934
Article Published Date : Sep 01, 2005
Study Type : Animal Study
Additional Links
Substances : Tocotrienols, Vitamin E
Diseases : Osteoporosis
Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation
[+]

Tocotrienol rich fractions of palm oil and rice bran oil protect against kidney damage associated with high blood sugar in type 1 diabetes.Dec 05, 2010

Pubmed Data : Chem Biol Interact. 2010 Dec 5;188(3):651-8. Epub 2010 Sep 28. PMID: 20816776
Article Published Date : Dec 05, 2010
Study Type : Animal Study
Additional Links
Substances : Palm Oil, Rice Bran, Tocotrienols
Diseases : Diabetes Mellitus: Type 1: Prevention, Oxidative Stress
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Renoprotective
[+]

Tocotrienol-rich fraction and tocopherol prevent aspirin-induced gastric lesions.Jan 01, 2002

Pubmed Data : Asia Pac J Clin Nutr. 2002;11(4):309-13. PMID: 12495264
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Substances : Tocotrienols, Vitamin E
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Gastroprotective, Malondialdehyde Down-regulation
[+]

Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice.Jan 01, 2018

Pubmed Data : J Nutr Biochem. 2018 07 ;57:77-85. Epub 2018 Mar 21. PMID: 29679925
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Tocotrienols
Diseases : Diabetes Mellitus: Type 2, Oxidative Stress
Pharmacological Actions : Antioxidant, Insulin Sensitizers
Problem Substances : Insulin
[+]

Tocotrienols ameliorate neurodegeneration and motor deficits in the 6-OHDA-induced rat model of Parkinsonism.May 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 May 10 ;13(5). Epub 2021 May 10. PMID: 34068460
Article Published Date : May 09, 2021
Study Type : Animal Study
Additional Links
Substances : Tocotrienols
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Tocotrienols and green tea polyphenols improve skeletal muscle metabolism in obese mice by improving glucose homeostasis, reducing lipid peroxidation, and increasing rate limiting enzymes of oxidative phosphorylation.May 01, 2019

Pubmed Data : J Nutr Biochem. 2019 May ;67:36-43. Epub 2019 Feb 10. PMID: 30852322
Article Published Date : May 01, 2019
Study Type : Animal Study
Additional Links
Substances : Green Tea, Tocotrienols
Diseases : Insulin Resistance, Obesity
Pharmacological Actions : Insulin Sensitizers
[+]

Tocotrienols are more effective than d-alpha tocopherol in protecting the bone from free radical damage.Mar 31, 2005

Pubmed Data : N Engl J Med. 2005 Mar 31;352(13):1293-304. Epub 2005 Mar 7. PMID: 18598299
Article Published Date : Mar 31, 2005
Study Type : Animal Study
Additional Links
Substances : Palm Tree, Tocotrienols
Diseases : Bone Diseases
Pharmacological Actions : Antioxidants
[+]

Tocotrienols inhibit hepatocarcinogenesis induced by 2-acetylaminofluorene in rats.Apr 01, 1991

Pubmed Data : Am J Clin Nutr. 1991 Apr ;53(4 Suppl):1076S-1081S. PMID: 1672785
Article Published Date : Apr 01, 1991
Study Type : Animal Study
Additional Links
Substances : Tocotrienols
Diseases : Liver Cancer
Pharmacological Actions : Antioxidants, Chemopreventive
[+]

A tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma cells.Feb 01, 2010

Pubmed Data : Phytother Res. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20127663
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Rice Bran, Tocotrienols
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Mesothelioma
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Annatto-derived tocotrienols enhance osteogenic activity.Jan 01, 2018

Pubmed Data : Drug Des Devel Ther. 2018 ;12:1715-1726. Epub 2018 Jun 13. PMID: 29942115
Article Published Date : Jan 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols
Pharmacological Actions : Osteogenic, Regenerative
Additional Keywords : Bone Regeneration, Phytotherapy
[+]

Dietary γT3-enriched food would be a simple strategy to attenuate adiposity and to lessen obesity-mediated metabolic dysfunction.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 ;21(3). Epub 2016 Mar 11. PMID: 26978344
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Tocotrienol: Delta, Tocotrienols, Vitamin E: Gamma-tocotrienol
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Gamma Tocotrienol (vitamin E fraction) induces cell death in human gastric cancer cells.Aug 01, 2009

Pubmed Data : Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1164-71. Epub 2009 May 28. PMID: 18602811
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols
Diseases : Human Gastric Adenocarcinoma
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Gamma- and delta-tocotrienol down-regulate cholesterol production. Sep 01, 2006

Pubmed Data : J Biol Chem. 2006 Sep 1;281(35):25054-61. Epub 2006 Jul 10. PMID: 16831864
Article Published Date : Sep 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta, Tocotrienols, Vitamin E
Diseases : High Cholesterol
[+]

Gamma-tocotrienol has broad therapeutic activity against human melanoma cells. Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(3):357-66. PMID: 19373609
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Gamma, Tocotrienols, Vitamin E: Gamma-tocotrienol
Diseases : Malignant Melanoma, Melanoma, Melanoma: Metastatic
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Neuroprotective and anti-obesity effects of tocotrienols.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2019 ;65(Supplement):S185-S187. PMID: 31619626
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Tocotrienols, Vitamin E
Diseases : Obesity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Anti-Obesity Agents
[+]

Palm oil and its tocotrienol-rich fractions enhance cognitive functions of healthy animals and in transgenic Alzheimer's and diabetes animals.Feb 18, 2020

Pubmed Data : Nutrients. 2020 Feb 18 ;12(2). Epub 2020 Feb 18. PMID: 32085610
Article Published Date : Feb 18, 2020
Study Type : Review
Additional Links
Substances : Palm Oil, Tocotrienols
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Palm tocotrienols inhibit proliferation of mouse mammary cancer cells.Dec 01, 2010

Pubmed Data : J Interferon Cytokine Res. 2010 Dec;30(12):909-16. PMID: 21121862
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Palm Oil, Tocotrienol: Alpha, Tocotrienol: Delta, Tocotrienol: Gamma, Tocotrienols
Diseases : Breast Cancer
[+]

The anti-inflammatory effect of unsaturated tocotrienols could be highly promising in the regulation of tumor microenvironments.Mar 06, 2016

Pubmed Data : Biofactors. 2016 Mar 7. Epub 2016 Mar 7. PMID: 26948691
Article Published Date : Mar 06, 2016
Study Type : Review
Additional Links
Substances : Tocotrienols, Vitamin E
Diseases : Cancer Metastasis
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic
Additional Keywords : Tumor Microenvironment
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Tocotrienols have potenti antifibrogenic effects which may help prevent and/or treat bowel stenosis in Crohn's disease patients.Aug 03, 2010

Pubmed Data : Inflamm Bowel Dis. 2010 Aug 3. Epub 2010 Aug 3. PMID: 20684017
Article Published Date : Aug 03, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols
Diseases : Bowel Stenosis, Crohn's Disease
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Tocotrienols induce programmed cell death in breast cancer cell lines. Feb 16, 2010

Pubmed Data : Breast Cancer Res Treat. 2010 Feb 16. Epub 2010 Feb 16. PMID: 20157774
Article Published Date : Feb 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Tocotrienols inhibit growth and induce programmed cell death in human cervical cancer cells. Feb 11, 2010

Pubmed Data : Integr Cancer Ther. 2010 Feb 11. Epub 2010 Feb 11. PMID: 20150225
Article Published Date : Feb 11, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Interleukin-6 upregulation
[+]

Tocotrienols: dietary supplements for chronic obstructive pulmonary disease.May 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2021 May 31 ;10(6). Epub 2021 May 31. PMID: 34072997
Article Published Date : May 30, 2021
Study Type : Review
Additional Links
Substances : Tocotrienols
Diseases : Chronic Obstructive Pulmonary Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor
[+]

[6]-gingerol and epigallocatechin gallate (EGCG) synergistically induced apoptosis and inhibits the proliferation 1321N1 and LN18 cells.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2014 ;19(9):14528-41. Epub 2014 Sep 12. PMID: 25221872
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Gingerol , Tocotrienols
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Tocotrienols induce cell death in human breast cancer cells.Jan 01, 1999

Pubmed Data : Nutr Cancer. 1999;33(1):26-32. PMID: 10227040
Article Published Date : Jan 01, 1999
Additional Links
Substances : Tocotrienols

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