Tripterygium wilfordii

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34 Diseases Researched for Tripterygium wilfordii
NameACCKFocus
Rheumatoid Arthritis341Locked
Lupus Nephritis333Locked
Spondylitis: Ankylosing121Locked
Organ Transplantation220Locked
Organ Transplantation: Kidney220Locked
Proteinuria212Locked
Arthritis: Rheumatoid110Locked
Crohn's Disease110Locked
Myasthenia Gravis110Locked
Multiple Sclerosis35Locked
Cancers: Drug Resistant23Locked
Leukemia: Chronic myelogenous leukemia (CML) 23Locked
Multiple Myeloma33Locked
Ovarian Cancer13Locked
Cholangiocarcinoma22Locked
HIV Infections22Locked
Kidney Diseases12Locked
Kidney Fibrosis12Locked
Membranoproliferative glomerulonephritis (MPGN)12Locked
Organ Transplantation: Skin 12Locked
Osteoarthritis12Locked
Polycystic Kidney Diseases12Locked
Thyroid Cancer22Locked
Acute Myeloid Leukemia11Locked
Autoimmune Diseases11Locked
Cancers: Multi-Drug Resistant11Locked
Chemically-Induced Liver Damage11Locked
Glaucoma11Locked
Leukemia11Locked
Leukemia: Acute myelogenous leukemia (AML) 11Locked
Leukemia: Chronic Lymphocytic Leukemia (CLL)11Locked
Myelodysplastic Syndrome11Locked
Nephritis11Locked
Prostate Cancer11Locked
24 Pharmacological Actions Researched for Tripterygium wilfordii
NameACCKFocus
Interleukin-6 Downregulation231Locked
Anti-Inflammatory Agents324Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor323Locked
Apoptotic710Locked
Chemosensitizer44Locked
NF-kappaB Inhibitor34Locked
Antiproliferative 13Locked
Immunosuppressive Agents23Locked
Interleukin-1 beta downregulation23Locked
Antioxidants22Locked
Chondroprotective12Locked
MicroRNA modulator12Locked
Renoprotective12Locked
Anti-HIV Agents11Locked
Anticarcinogenic Agents11Locked
Antineoplastic Agents11Locked
Antiviral Agents11Locked
Heme oxygenase-1 up-regulation11Locked
Hepatoprotective11Locked
Interleukin-8 downregulation11Locked
Neuroprotective Agents11Locked
Nrf2 activation11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Vascular Endothelial Growth Factor A Inhibitor11Locked

View the Evidence:
37 Abstracts with Tripterygium wilfordii Research

[+]

Effectiveness and safety of tripterygium glycosides tablet for lupus nephritis.Sep 30, 2022

Pubmed Data : J Tradit Chin Med. 2022 Oct ;42(5):671-680. PMID: 36083472
Article Published Date : Sep 30, 2022
Study Type : Meta Analysis, Review
Additional Links
Substances : Tripterygium wilfordii
Diseases : Lupus Nephritis
Additional Keywords : Significant Treatment Outcome
[+]

Protective effect and possible Mechanisms of Tripterygium glycosides in patients with ankylosing spondylitis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:9374895. Epub 2022 Mar 3. PMID: 35281463
Article Published Date : Dec 31, 2021
Study Type : Meta Analysis, Review
Additional Links
Substances : Tripterygium wilfordii
Diseases : Spondylitis: Ankylosing
[+]

The combination of tripterygium glycosides is superior to conventional DMARD monotherapy in improving rheumatoid arthritis conditions.Aug 23, 2022

Pubmed Data : Pharmacol Res. 2022 Aug 24 ;184:106405. Epub 2022 Aug 24. PMID: 36028187
Article Published Date : Aug 23, 2022
Study Type : Meta Analysis, Review
Additional Links
Substances : Tripterygium wilfordii
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A compound from Tripterygium wilfordii appears to be effective for the treatment of mildly or moderately active Crohn's disease. Aug 01, 2007

Pubmed Data : Dig Dis Sci. 2007 Aug;52(8):1790-7. Epub 2007 Apr 5. PMID: 17410440
Article Published Date : Aug 01, 2007
Study Type : Human Study
Additional Links
Substances : Tripterygium wilfordii
[+]

Tripterygium has treatment value in patiens with lupus nephritis. May 01, 2008

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2008 May;33(9):1075-7. PMID: 18652362
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Lupus Nephritis
[+]

Tripterygium wilfordii contains a compound which improves the safety and efficacy of methotrexate treatment in rheumatoid arthritis. Dec 01, 2001

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Dec;21(12):895-6. PMID: 12575588
Article Published Date : Dec 01, 2001
Study Type : Human Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Arthritis: Rheumatoid, Rheumatoid Arthritis
Additional Keywords : Drug Side Effect Attenuation
[+]

Tripterygium wilfordii has a synergistic effect on the efficacy of prednisone in the treatment of myasthenia gravis. Mar 01, 2002

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Mar;22(3):175-7. PMID: 12585099
Article Published Date : Mar 01, 2002
Study Type : Human Study
Additional Links
Substances : Thunder god vine, Tripterygium wilfordii
Diseases : Myasthenia Gravis
Pharmacological Actions : Interleukin-6 Downregulation
Additional Keywords : Drug-Plant-Vitamin Synergies, Drug Sparing
[+]

Tripterygium wilfordii Hook F was well tolerated and prolonged remission in patients with Crohn's disease.Oct 31, 2015

Pubmed Data : Am J Med Sci. 2015 Nov ;350(5):345-51. PMID: 26473333
Article Published Date : Oct 31, 2015
Study Type : Human Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Crohn's Disease
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Tripterygium wilfordii increases long-term kidney transplant survival among transplant recipients. Jun 01, 2006

Pubmed Data : Transplant Proc. 2006 Jun;38(5):1274-9. PMID: 16797280
Article Published Date : Jun 01, 2006
Study Type : Human Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Organ Transplantation, Organ Transplantation: Kidney
[+]

Tripterygium wilfordii is superior to sulfasalazine in treating rheumatoid arthritis. Aug 18, 2009

Pubmed Data : Ann Intern Med. 2009 Aug 18;151(4):229-40, W49-51. PMID: 19687490
Article Published Date : Aug 18, 2009
Study Type : Human Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Rheumatoid Arthritis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Tripterygium wilfordii markedly reduces proteinuria associated with the immunosuppressive drug Sirolimus in renal transplant patients. Jan 22, 2009

Pubmed Data : Vet Parasitol. 2009 Jan 22;159(1):55-9. Epub 2008 Oct 15. PMID: 19100416
Article Published Date : Jan 22, 2009
Study Type : Human Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Organ Transplantation, Organ Transplantation: Kidney, Proteinuria
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Synergistic effect of Tripterygium glycosides and cisplatin on drug-resistant human epithelial ovarian cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2022 ;14(3):2051-2062. Epub 2022 Mar 15. PMID: 35422913
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Cordyceps and Tripterygium hypoglaucum prolong the survival time of allogenic grafted pigskin. Mar 01, 2006

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2006 Mar;4(2):185-8. PMID: 16529697
Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Substances : Cordyceps sinensis, Tripterygium wilfordii
Diseases : Organ Transplantation: Skin
[+]

Protective effects of Tripterygium glycoside on IL-1β-induced inflammation and apoptosis of rat chondrocytes.Sep 01, 2022

Pubmed Data : Immunopharmacol Immunotoxicol. 2022 Sep 2:1-12. Epub 2022 Sep 2. PMID: 36052873
Article Published Date : Sep 01, 2022
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation
[+]

The principal active components of the Chinese herbal remedy Tripterygium wilfordii significantly ameliorated lupus nephritis in mice. Jun 01, 2008

Pubmed Data : Arthritis Rheum. 2008 Jun;58(6):1774-83. PMID: 18512813
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Lupus Nephritis
[+]

Tripterygium wilfordii may ameliorate proteinuria and mesangial lesions in Membranoproliferative glomerulonephritis (MPGN). Dec 01, 2006

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Dec;26(12):1094-102. PMID: 17205822
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Membranoproliferative glomerulonephritis (MPGN), Proteinuria
[+]

Triptolide showed a protective effect against renal fibrosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:814089. Epub 2015 Sep 14. PMID: 26451157
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Kidney Diseases, Kidney Fibrosis
Pharmacological Actions : MicroRNA modulator, Renoprotective
[+]

Triptolide, a compound found within Tripterygium wilfordii, ameliorates clinical signs of experimental autoimmune encephalomyelitis . Dec 10, 2009

Pubmed Data : J Neuroimmunol. 2009 Dec 10;217(1-2):28-37. Epub 2009 Sep 30. PMID: 19796825
Article Published Date : Dec 10, 2009
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Multiple Sclerosis
Pharmacological Actions : NF-kappaB Inhibitor
[+]

Triptolide, a compound found within Tripterygium wilfordii, attenuates polycystic kidney disease in an animal model. Mar 13, 2007

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4389-94. Epub 2007 Mar 6. PMID: 17360534
Article Published Date : Mar 13, 2007
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Polycystic Kidney Diseases
[+]

Triptolide, a compound from Tripterygium wildordii, shows promise in an experimental model of Multiple Sclerosis. Aug 01, 2009

Pubmed Data : J Med Food. 2009 Aug;12(4):714-21. PMID: 18438925
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Multiple Sclerosis
Pharmacological Actions : Immunosuppressive Agents
[+]

Triptolide, a constituent of Tripterygium wilfordii, induces programmed cell death in drug-resistant chronic myelogenous leukemia cells. Mar 01, 2009

Pubmed Data : Clin Cancer Res. 2009 Mar 1;15(5):1686-97. Epub 2009 Feb 24. PMID: 19240172
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.Jul 28, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Mol Biol. 2011 Jul 29 ;410(5):972-83. PMID: 21763500
Article Published Date : Jul 28, 2011
Study Type : Review
Additional Links
Substances : Celastrol, Tripterygium wilfordii
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
[+]

Chemosensitizing effect and efficacy of Wilforlide A in combination with docetaxel in drug-resistant prostate cancer.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2022 Sep-Oct;36(5):2020-2031. PMID: 36099129
Article Published Date : Aug 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Cancers: Drug Resistant, Prostate Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Docetaxel
[+]

Ginsenoside Rb1 attenuates triptolide-induced cytotoxicity in HL-7702 cells via the activation of keap1/Nrf2/ARE pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:723784. Epub 2022 Jan 3. PMID: 35046796
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides, Tripterygium wilfordii
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Treatment of glaucoma with natural products and their mechanism of action: an update.Jan 25, 2022

Pubmed Data : Nutrients. 2022 Jan 26 ;14(3). Epub 2022 Jan 26. PMID: 35276895
Article Published Date : Jan 25, 2022
Study Type : Review
Additional Links
Substances : Anthocyanins, Baicalein, Barberry, Caffeine, Cannabis, Coenzyme Q10, Curcumin, Ginkgo biloba, Ginsenosides, Hesperidin, Resveratrol, Saffron, Tripterygium wilfordii, Vitamin B-3 (Niacin), Vitamin D
Diseases : Glaucoma
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Tripterygium wilfordii contains a compound with anti-HIV activity. Oct 01, 1995

Pubmed Data : Bioorg Med Chem. 1995 Oct;3(10):1345-8. PMID: 8564400
Article Published Date : Oct 01, 1995
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : HIV Infections
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Tripterygium wilfordii may contribute to a reduction in autoimmunity in diseases like Multiple Sclerosis. Dec 01, 2008

Pubmed Data : Yao Xue Xue Bao. 2008 Dec;43(12):1179-85. PMID: 19244746
Article Published Date : Dec 01, 2008
Study Type : Commentary
Additional Links
Substances : Tripterygium wilfordii
Diseases : Autoimmune Diseases, Multiple Sclerosis
Pharmacological Actions : Immunosuppressive Agents
[+]

Triptolide (Tripterygium wilfordii) has potent pro-apoptotic effect in primary acute myeloid leukemia.Jul 15, 2006

Pubmed Data : Blood. 2006 Jul 15;108(2):630-7. Epub 2006 Mar 23. PMID: 16556893
Article Published Date : Jul 15, 2006
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Triptolide induces cell apoptosis by targeting H3K4me3 and downstream effector proteins in KM3 multiple myeloma cells.Sep 29, 2015

Pubmed Data : Curr Pharm Biotechnol. 2015 Sep 30. Epub 2015 Sep 30. PMID: 26420049
Article Published Date : Sep 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Multiple Myeloma
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Vascular Endothelial Growth Factor A Inhibitor
[+]

Triptolide inhibits transcription factor NF-kappa B, which translates into a therapeutic effect against various leukemias, multiple myeloma and myelodysplastic syndrome.Jul 02, 2010

Pubmed Data : Curr Mol Pharmacol. 2010 Jul 2. Epub 2010 Jul 2. PMID: 20594187
Article Published Date : Jul 02, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Leukemia, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic Lymphocytic Leukemia (CLL), Leukemia: Chronic myelogenous leukemia (CML) , Multiple Myeloma, Myelodysplastic Syndrome
Pharmacological Actions : Chemosensitizer, NF-kappaB Inhibitor
[+]

Triptolide, a compound found within Tripterygium wilfordii, enhances the growth inhibitory effect of dexamtheasone in multiple myeloma cell lines. May 01, 2009

Pubmed Data : Leuk Lymphoma. 2009 May;50(5):802-8. PMID: 19330649
Article Published Date : May 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Multiple Myeloma
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Triptolide, a compound found within Tripterygium wilfordii, has a synergistic effect with TNF-alpha against cholangiocarcinoma. Sep 01, 2002

Pubmed Data : Asian Pac J Allergy Immunol. 2002 Sep;20(3):167-73. PMID: 12587840
Article Published Date : Sep 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Triptolide, a compound found within Tripterygium wilfordii, has therapeutic value in the treatment of multi-drug resistant cacer cells. Feb 15, 2010

Pubmed Data : Anticancer Drugs. 2010 Feb 15. Epub 2010 Feb 15. PMID: 20154595
Article Published Date : Feb 15, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: 5-flourouracil, Drug-Plant-Vitamin Synergies
[+]

Triptolide, a compound found within Tripterygium wilfordii, induces programmed cell death in human anaplastic thyroid cancer. Dec 01, 2009

Pubmed Data : Oncol Rep. 2009 Dec;22(6):1397-401. PMID: 19885592
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Thyroid Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Triptolide, a compound found within Tripterygium wilfordii, sensitizes cholangiocarcinoma cells to programmed cell death. Jan 01, 2006

Pubmed Data : Anticancer Res. 2006 Jan-Feb;26(1A):259-65. PMID: 16475706
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Cholangiocarcinoma
Pharmacological Actions : Apoptotic, Chemosensitizer, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Triptolide, a compound from Tripterygium wilforidii, may inhibit thyroid cancer. Jun 01, 2008

Pubmed Data : Magnes Res. 2008 Jun;21(2):77-82. PMID: 19158360
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Thyroid Cancer
[+]

Valsartan in combination with Tripterygium glycosides protects against chronic nephritis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anal Cell Pathol (Amst). 2022 ;2022:4807028. Epub 2022 Aug 24. PMID: 36061150
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Nephritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-8 downregulation
Additional Keywords : Natural Substance/Drug Synergy

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