Unsaponifiables

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5 Diseases Researched for Unsaponifiables

Name	AC	CK
Osteoarthritis: Hip	2	20
Osteoarthritis	5	15
Osteoarthritis: Knee	1	10
Ulcerative Colitis	1	2
Rheumatoid Arthritis	1	1

7 Pharmacological Actions Researched for Unsaponifiables

Name	AC	CK
Interleukin-1 alpha downregulation	2	2
Interleukin-1 beta downregulation	2	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Nitric Oxide Inhibitor	1	2
Prostaglandin Antagonists	2	2
Cyclooxygenase 2 Inhibitors	1	1
NF-kappaB Inhibitor	1	1

Research Articles 7
Cumulative Knowledge Score 11
Overall Research Rating GOOD

View the Evidence:
7 Abstracts with Unsaponifiables Research

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Avocado/soybean unsaponifiables appear to have a preventive effect on joint space loss in osteoarthritis of the hip.Feb 01, 2002

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Pubmed Data : Arthritis Rheum. 2002 Feb;47(1):50-8. PMID: 11932878

Article Published Date : Feb 01, 2002

Study Type : Human Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis: Hip

[+]

Avocado/soybean unsaponifiables are safe and effective in the treatment of symptomatic osteoarthritis of the knee and hip.Dec 01, 1997

Click here to read the entire abstract

Pubmed Data : Rev Rhum Engl Ed. 1997 Dec;64(12):825-34. PMID: 9476272

Article Published Date : Dec 01, 1997

Study Type : Human Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis, Osteoarthritis: Hip , Osteoarthritis: Knee

Additional Keywords : Drug Sparing, Plant Extracts

[+]

"Dietary unsaponificable fraction from extra virgin olive oil supplementation attenuates acute ulcerative colitis in mice."Dec 09, 2012

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Pubmed Data : Eur J Pharm Sci. 2012 Dec 10. Epub 2012 Dec 10. PMID: 23238173

Article Published Date : Dec 09, 2012

Study Type : Animal Study

Additional Links

Substances : Olive Oil, Unsaponifiables

Diseases : Ulcerative Colitis

[+]

Avocado/soybean unsaponifiables have a protective effect against experimental dog osteoarthritis. Jan 01, 2009

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Pubmed Data : Arthritis Res Ther. 2009;11(2):R41. Epub 2009 Mar 16. PMID: 19291317

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables , Vitamin E

Diseases : Osteoarthritis

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor

Additional Keywords : Plant Extracts

[+]

Avocado soybean unsaponifiables and epigallocatechin gallate reduce inflammation in chondrocytes. Dec 01, 2004

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Pubmed Data : J Chem Neuroanat. 2004 Dec;28(4):253-64. PMID: 19748608

Article Published Date : Dec 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Avocado, EGCG (Epigallocatechin gallate), Soy, Unsaponifiables

Diseases : Osteoarthritis

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin Antagonists

[+]

Avocado/soy unsaponifiables have a protective effect against inflammation within articular chondrocytes.Jun 01, 2008

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Pubmed Data : Evid Based Complement Alternat Med. 2008 Jun;5(2):191-7. PMID: 18604259

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis

Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Prostaglandin Antagonists

[+]

Unsaponifiable extracts of avocado and soybean may inhibit the deleterious effects of interleukin-1 in osteoarticular diseases. Apr 01, 1991

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Pubmed Data : Rev Rhum Mal Osteoartic. 1991 Apr;58(4):241-5. PMID: 1647544

Article Published Date : Apr 01, 1991

Study Type : In Vitro Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis, Rheumatoid Arthritis

Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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View the Evidence: 7 Abstracts with Unsaponifiables Research

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Avocado/soybean unsaponifiables appear to have a preventive effect on joint space loss in osteoarthritis of the hip.Feb 01, 2002

Click here to read the entire abstract

Avocado/soybean unsaponifiables are safe and effective in the treatment of symptomatic osteoarthritis of the knee and hip.Dec 01, 1997

Click here to read the entire abstract

"Dietary unsaponificable fraction from extra virgin olive oil supplementation attenuates acute ulcerative colitis in mice."Dec 09, 2012

Click here to read the entire abstract

Avocado/soybean unsaponifiables have a protective effect against experimental dog osteoarthritis. Jan 01, 2009

Click here to read the entire abstract

Avocado soybean unsaponifiables and epigallocatechin gallate reduce inflammation in chondrocytes. Dec 01, 2004

Click here to read the entire abstract

Avocado/soy unsaponifiables have a protective effect against inflammation within articular chondrocytes.Jun 01, 2008

Click here to read the entire abstract

Unsaponifiable extracts of avocado and soybean may inhibit the deleterious effects of interleukin-1 in osteoarticular diseases. Apr 01, 1991

Click here to read the entire abstract

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Unsaponifiables

View the Evidence:
7 Abstracts with Unsaponifiables Research