Unsaponifiables

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5 Diseases Researched for Unsaponifiables

Name	AC	CK	Focus
Osteoarthritis: Hip	2	20
Osteoarthritis	5	15
Osteoarthritis: Knee	1	10
Ulcerative Colitis	1	2
Rheumatoid Arthritis	1	1

7 Pharmacological Actions Researched for Unsaponifiables

Name	AC	CK	Focus
Interleukin-1 alpha downregulation	2	2
Interleukin-1 beta downregulation	2	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Nitric Oxide Inhibitor	1	2
Prostaglandin Antagonists	2	2
Cyclooxygenase 2 Inhibitors	1	1
NF-kappaB Inhibitor	1	1

Research Articles 7
Cumulative Knowledge Score 11
Overall Research Rating GOOD

View the Evidence:
7 Abstracts with Unsaponifiables Research

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Avocado/soybean unsaponifiables appear to have a preventive effect on joint space loss in osteoarthritis of the hip.Feb 01, 2002

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Pubmed Data : Arthritis Rheum. 2002 Feb;47(1):50-8. PMID: 11932878

Article Published Date : Feb 01, 2002

Study Type : Human Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis: Hip

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Avocado/soybean unsaponifiables are safe and effective in the treatment of symptomatic osteoarthritis of the knee and hip.Dec 01, 1997

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Pubmed Data : Rev Rhum Engl Ed. 1997 Dec;64(12):825-34. PMID: 9476272

Article Published Date : Dec 01, 1997

Study Type : Human Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis, Osteoarthritis: Hip , Osteoarthritis: Knee

Additional Keywords : Drug Sparing, Plant Extracts

[+]

"Dietary unsaponificable fraction from extra virgin olive oil supplementation attenuates acute ulcerative colitis in mice."Dec 09, 2012

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Pubmed Data : Eur J Pharm Sci. 2012 Dec 10. Epub 2012 Dec 10. PMID: 23238173

Article Published Date : Dec 09, 2012

Study Type : Animal Study

Additional Links

Substances : Olive Oil, Unsaponifiables

Diseases : Ulcerative Colitis

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Avocado/soybean unsaponifiables have a protective effect against experimental dog osteoarthritis. Jan 01, 2009

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Pubmed Data : Arthritis Res Ther. 2009;11(2):R41. Epub 2009 Mar 16. PMID: 19291317

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables , Vitamin E

Diseases : Osteoarthritis

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor

Additional Keywords : Plant Extracts

[+]

Avocado soybean unsaponifiables and epigallocatechin gallate reduce inflammation in chondrocytes. Dec 01, 2004

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Pubmed Data : J Chem Neuroanat. 2004 Dec;28(4):253-64. PMID: 19748608

Article Published Date : Dec 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Avocado, EGCG (Epigallocatechin gallate), Soy, Unsaponifiables

Diseases : Osteoarthritis

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin Antagonists

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Avocado/soy unsaponifiables have a protective effect against inflammation within articular chondrocytes.Jun 01, 2008

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Pubmed Data : Evid Based Complement Alternat Med. 2008 Jun;5(2):191-7. PMID: 18604259

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis

Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Prostaglandin Antagonists

[+]

Unsaponifiable extracts of avocado and soybean may inhibit the deleterious effects of interleukin-1 in osteoarticular diseases. Apr 01, 1991

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Pubmed Data : Rev Rhum Mal Osteoartic. 1991 Apr;58(4):241-5. PMID: 1647544

Article Published Date : Apr 01, 1991

Study Type : In Vitro Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis, Rheumatoid Arthritis

Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

Copyright: korzeniewskidaniel / 123RF Stock Photo

Research Articles 7
Cumulative Knowledge Score 11
Overall Research Rating GOOD

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