Ursolic Acid

Name	AC	CK
Breast Cancer	17	21
Alzheimer's Disease	9	17
Colorectal Cancer	15	17
Oxidative Stress	10	13
Cancers: All	10	11
Diabetic Nephropathy	5	11
Obesity	6	11
Cancers: Drug Resistant	10	10
Chemically-Induced Liver Damage	5	9
Diabetes Mellitus: Type 2	4	8
Gastric Cancer	5	8
High Fat Diet	4	8
Inflammation	5	8
Insulin Resistance	4	8
Parkinson's Disease	5	8
Colon Cancer	7	7
Liver Fibrosis	4	7
Ovarian Cancer	3	7
Prostate Cancer	6	7
Atherosclerosis	4	6
Cerebral Ischemia	4	6
Depression	4	6
Liver Cancer	6	6
Lung Cancer	5	6
Anxiety	3	5
Breast Cancer: Triple Negative	5	5
Liver Cirrhosis	2	5
Memory Disorders	1	5
Osteoporosis	3	5
Aging	2	4
Diabetic Complications	2	4
Dysbiosis	2	4
Emphysema: Pulmonary	2	4
Esophageal Cancer	3	4
Glioblastoma	2	4
Hepatic Steatosis	2	4
Hypercholesterolemia	2	4
Multiple Sclerosis	2	4
Muscle Atrophy	2	4
Mycobacterium Tuberculosis	4	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Smoking	2	4
Spinal Cord Injuries	2	4
Ulcerative Colitis	2	4
Brain Inflammation	2	3
Cervical Cancer	2	3
Cognitive Decline/Dysfunction	2	3
DNA damage	3	3
Gallbladder Cancer	2	3
Kidney Damage	2	3
Myocardial Ischemia	2	3
Osteosarcoma	3	3
Pancreatic Cancer	1	3
Skin Cancer	2	3
Thyroid Cancer	2	3
Tuberculosis	2	3
Air Pollution Linked Toxicity	1	2
Alcoholic Liver Disease	1	2
Allergic Rhinitis	1	2
Aortic Aneurysm	1	2
Arteriosclerosis	1	2
Arthritis	1	2
Atopic Dermatitis	1	2
Cachexia: Cancer	1	2
Cancer Metastasis	2	2
Carcinoma: Non-Small-Cell Lung	2	2
Cardiomyopathy	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chronic Obstructive Pulmonary Disease	1	2
Coronavirus Infection	2	2
Dementia	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Epilepsy	1	2
Fatty Liver	1	2
Gastrointestinal Diseases	1	2
Gestational Diabetes	1	2
High Cholesterol	1	2
Hyperalgesia	1	2
Hyperinsulinism	1	2
Inflammatory Bowel Diseases	1	2
Intestinal Ischemia	1	2
Intracerebral Hemorrhage	1	2
Ischemia	1	2
Kidney Cancer	2	2
Lung Injury: Smoke-Induced	1	2
Multiple Myeloma	2	2
Myocardial Fibrosis	1	2
Myocardial Infarction	1	2
Myocarditis: Autoimmune	1	2
Neurodegenerative Diseases	1	2
Non-Small-Cell Lung Carcinoma	1	2
Oral Cancer	2	2
Pancreatitis	1	2
Pulmonary Emphysema	1	2
Restenosis	1	2
Sciatic Nerve Crush Injury	1	2
Sciatica	1	2
Staphylococcus aureus infection	2	2
Steptococcus Mutans Infections	2	2
Streptococcus Infections	2	2
Traumatic Brain Injury	1	2
Wound Healing	1	2
Aflatoxicosis	1	1
Autoimmune Thyroiditis	1	1
Bacillus Cereus infection	1	1
Bladder Cancer	1	1
Breast Cancer: estrogen receptor alpha-positive	1	1
Cardiovascular Diseases	1	1
Dental Caries	1	1
Diabetic Neuropathy	1	1
Endometrial Cancer	1	1
Enterobacteriaceae Infections	1	1
Enterococcus Infections	1	1
Enterovirus 71	1	1
Escherichia coli Infections	1	1
Hearing Loss	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
High Sugar Diet	1	1
Human Papillomavirus (HPV)	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Infection: Antibiotic Resistant	1	1
Influenza A	1	1
Kidney Damage: Chemically-Induced	1	1
Klebsiella Infections	1	1
Klesiella Pneumonia Infection	1	1
Leishmaniasis	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Malaria	1	1
Melanoma	1	1
Mesothelioma	1	1
Respiratory Diseases	1	1
Rotavirus Infections	1	1
Sarcomas	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Stroke: Ischemic	1	1
Testicular Cancer	1	1
Toxoplasma gondii Infection	1	1
Toxoplasmosis	1	1

Name	AC	CK
Anti-Inflammatory Agents	49	101
Antioxidants	34	75
Antiproliferative	57	70
Apoptotic	46	62
Neuroprotective Agents	21	39
Interleukin-6 Downregulation	8	32
Tumor Necrosis Factor (TNF) Alpha Inhibitor	8	32
Interleukin-1 beta downregulation	7	31
Chemosensitizer	16	27
NF-kappaB Inhibitor	17	26
Hepatoprotective	12	23
Interleukin-8 downregulation	1	21
Chemotherapeutic	14	17
Anti-metastatic	14	15
Gastrointestinal Agents	7	14
Anti-Apoptotic	7	12
Anti-Fibrotic	6	12
Cardioprotective	7	12
Chemopreventive	10	11
Autophagy Up-regulation	6	10
Cell cycle arrest	9	10
Gastroprotective	4	8
Immunomodulatory	5	8
Nrf2 activation	4	8
Renoprotective	5	8
Anti-Bacterial Agents	6	7
Anticarcinogenic Agents	5	7
MicroRNA modulator	6	7
Hypoglycemic Agents	3	6
Neurogenesis	3	6
Antidepressive Agents	3	5
Antiviral Agents	5	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	5
Osteoprotective	3	5
Wnt/β-catenin signaling pathway modulation	5	5
Anti-Anxiety Agents	2	4
Anticholesteremic Agents	2	4
Cyclooxygenase 2 Inhibitors	4	4
Enzyme Activators	2	4
Heme oxygenase-1 up-regulation	2	4
Interleukin-10 upregulation	2	4
Interleukin-18 down-regulation	2	4
Anti-atherogenic	2	3
Antimicrobial	3	3
Caspase-3 Activation	2	3
Caspase-9 Activation	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	3
STAT3 Inhibitor	3	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Alpha-glucosidase inhibitor	1	2
Analgesics	1	2
Angiogenesis Inhibitors	1	2
Anti-Cachexic Agents	1	2
Antineoplastic Agents	2	2
Antiparasitic Agents	2	2
Chemoprotective Agents	1	2
Cyclin D1 Down-Regulation	2	2
Genoprotective	2	2
Insulin-releasing	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Radioprotective	1	2
Radiosensitizer	2	2
SIRT1 Activator	1	2
Superoxide Dismutase Up-regulation	1	2
Anti-Infective Agents	1	1
Antimalarials	1	1
Antimutagenic Agents	1	1
Antimycobacterial	1	1
Autophagy Inhibitors	1	1
Bcl-2 protein down-regulation	1	1
Cytoprotective	1	1
DNA Repair Up-regulation	1	1
Estrogen Receptor Modulators	1	1
Heat Shock Protein Down-Regulation	1	1
Interleukin-18 upregulation	1	1
Interleukin-4 downregulation	1	1
Interleukin-5 downregulation	1	1
Leishmanicidal	1	1
Multidrug Resistance Gene Modulators	1	1
Nitric Oxide Enhancer	1	1
P21 Activation	1	1
Superoxide Scavenger	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
interleukin-13 down-regulation	1	1

[+]

Anti-inflammatory and antioxidant activity of ursolic acidDec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2023 ;14:1256946. Epub 2023 Sep 28. PMID: 37841938

Article Published Date : Dec 31, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Ursolic Acid

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment.Oct 04, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Oleo Sci. 2022 Feb 3 ;71(2):289-300. Epub 2022 Jan 14. PMID: 35034940

Article Published Date : Feb 02, 2022

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Diabetes Mellitus: Type 2, Obesity

Pharmacological Actions : Antioxidants, Hypoglycemic Agents

Additional Keywords : Anti-Obesity Agents

[+]

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2020 Dec 23:e13597. Epub 2020 Dec 23. PMID: 33368405

Article Published Date : Dec 22, 2020

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Oleanolic acid and ursolic acid improve bone properties and calcium nalance and modulate vitamin D metabolism in aged female rats.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis.Jan 30, 2021

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2021 Jan 31 ;83:153490. Epub 2021 Jan 31. PMID: 33601255

Article Published Date : Jan 30, 2021

Study Type : Animal Study

Additional Links

Substances : Rosmarinic acid, Ursolic Acid

Diseases : Alzheimer's Disease

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

[+]

Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy.Jan 07, 2020

Click here to read the entire abstract

Pubmed Data : J Control Release. 2020 Jan 8 ;320:168-178. Epub 2020 Jan 8. PMID: 31926193

Article Published Date : Jan 07, 2020

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Chemotherapeutic, Immunomodulatory

Additional Keywords : Tumor Microenvironment

[+]

Synergistic effect of ursolic acid and piperine in CCl 4 induced hepatotoxicity.Nov 30, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

[+]

Ursolic acid ameliorates myocardial ischaemia/reperfusion injury.Feb 19, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2023 Feb 20 ;15(4). Epub 2023 Feb 20. PMID: 36839407

Article Published Date : Feb 19, 2023

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Ursolic acid ameliorates obesity of mice fed with high-fat diet.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

[+]

Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson's disease model.Sep 21, 2022

Click here to read the entire abstract

Pubmed Data : Acta Pharmacol Sin. 2022 Sep 22. Epub 2022 Sep 22. PMID: 36138143

Article Published Date : Sep 21, 2022

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2024 Sep 10 ;138:112463. Epub 2024 Jul 6. PMID: 38971110

Article Published Date : Sep 09, 2024

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Intestinal Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Ursolic acid induced neural regeneration after sciatic nerve injury in mice. Sep 24, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neural Regen Res. 2013 Sep 25 ;8(27):2510-9. PMID: 25206561

Pubmed Data : Atherosclerosis. 2006 Jan;184(1):53-62. PMID: 15922347

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Arteriosclerosis, Restenosis

[+]

Ursolic acid may ameliorate the deleterious effects of diet-induced obesity and associated complications such as hepatic fibrosis.Nov 08, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Nov 9 ;10(11). Epub 2018 Nov 9. PMID: 30423963

Click here to read the entire abstract

Pubmed Data : Chin J Integr Med. 2019 Mar ;25(3):210-215. Epub 2018 Aug 30. PMID: 30159645

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Problem Substances : Retinoic Acid

[+]

Ursolic acid nanoparticles inhibited cervical cancer cell proliferation via apoptosis induction.Feb 21, 2017

Click here to read the entire abstract

Pubmed Data : Int J Oncol. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28259944

Article Published Date : Feb 21, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Colloids Surf B Biointerfaces. 2021 Mar 24 ;203:111720. Epub 2021 Mar 24. PMID: 33819820

Article Published Date : Mar 23, 2021

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Inhibitory effect and mechanism of ursolic acid on cisplatin-induced resistance and stemness in human lung cancer A549 cells.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2023 ;2023:1307323. Epub 2023 Apr 14. PMID: 37089712

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2021 Nov 15 ;280:114410. Epub 2021 Jul 15. PMID: 34273447

Article Published Date : Nov 14, 2021

Study Type : Review

Additional Links

Substances : Berberine, Tannic Acid, Ursolic Acid, Xanthohumol

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents

[+]

Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity.Jul 25, 2019

Click here to read the entire abstract

Pubmed Data : Toxicon. 2019 Jul 26. Epub 2019 Jul 26. PMID: 31356822

Click here to read the entire abstract

Pubmed Data : J BUON. 2020 Mar-Apr;25(2):750-756. PMID: 32521863

Article Published Date : Feb 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Anticancer effect of ursolic acid via mitochondria-dependent pathways.May 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Urologia. 2023 Sep 30:3915603231202304. Epub 2023 Sep 30. PMID: 37776274

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicine (Baltimore). 2023 Jul 28 ;102(30):e34362. PMID: 37505165

Article Published Date : Jul 27, 2023

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Atherosclerosis

Pharmacological Actions : Anti-atherogenic

Additional Keywords : Gene Expression Regulation

[+]

Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Lett. 2009 Aug 28;281(2):162-70. Epub 2009 Apr 2. PMID: 19344998

Article Published Date : Aug 28, 2009

Study Type : In Vitro Study

Additional Links

Substances : Luteolin, Quercetin, Ursolic Acid

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2016 Jul 27:1-7. Epub 2016 Jul 27. PMID: 27461151

Article Published Date : Jul 26, 2016

Study Type : In Vitro Study

Additional Links

Substances : Puerarin, Ursolic Acid

Diseases : DNA damage, Hydrogen Peroxide Induced Toxicity

Pharmacological Actions : Antioxidants, Genoprotective

[+]

Reactive oxygen species-mediated autophagy by ursolic acid inhibits growth and metastasis of esophageal cancer cells.Dec 09, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer Prev. 2015 Dec ;20(4):223-31. Epub 2015 Dec 30. PMID: 26734584

Article Published Date : Nov 30, 2015

Study Type : Review

Additional Links

Substances : Capsaicin, Curcumin, Genipin, Lycopene, Ursolic Acid

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive

[+]

The results suggest these compounds show potential for further optimization as antiviral candidates for treatment of EV71 infections.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Int J Mol Sci. 2023 Apr 18 ;24(8). Epub 2023 Apr 18. PMID: 37108576

Article Published Date : Apr 17, 2023

Study Type : Review

Additional Links

Substances : Ursolic Acid

Diseases : Bladder Cancer, Kidney Cancer, Prostate Cancer, Testicular Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Ursolic acid ameliorated neuronal damage by restoring microglia-activated MMP/TIMP imbalance.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Korean J Physiol Pharmacol. 2023 Sep 1 ;27(5):493-511. PMID: 37641811

Article Published Date : Aug 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Esophageal Cancer

Pharmacological Actions : Chemopreventive, Chemotherapeutic

[+]

Ursolic acid and acteoside regulates multiple targets, bioprocesses and signal pathways against Alzheimer's disease pathogenesis.Nov 30, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Sci Monit. 2019 Feb 17 ;25:1283-1290. Epub 2019 Feb 17. PMID: 30772887

Article Published Date : Feb 16, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Ursolic acid appears to be an effective therapeutic agent against colon cancer.Aug 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Nov 1 ;31(11):1371-1376. PMID: 29798594

Article Published Date : Oct 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation

[+]

Ursolic acid can inhibit the growth and metastasis of colorectal cancer.Sep 14, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Cancer Res. 2012 Sep 15 ;18(18):4942-53. Epub 2012 Jul 25. PMID: 22832932

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2019 Sep ;18(3):2628-2638. Epub 2019 Jul 4. PMID: 31404298

Article Published Date : Aug 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Pubmed Data : Br J Nutr. 2009 Apr;101(8):1145-9. PMID: 15583801

Article Published Date : Apr 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Endometrial Cancer

Pharmacological Actions : Apoptotic

[+]

Ursolic acid inhibited the proliferation of A549 and H460 cells in a concentration-dependent manner.Mar 12, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Cytokine. 2019 Jul 11 ;123:154726. Epub 2019 Jul 11. PMID: 31302461

Article Published Date : Jul 10, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Kidney Damage

Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ursolic acid is a potential anticancer compound for breast cancer therapy.Mar 03, 2018

Click here to read the entire abstract

Pubmed Data : Crit Rev Food Sci Nutr. 2018 Mar 4 ;58(4):568-574. Epub 2017 Oct 4. PMID: 27469428

Article Published Date : Mar 03, 2018

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2019 Sep 23 ;24(19). Epub 2019 Sep 23. PMID: 31547522

Article Published Date : Sep 22, 2019

Study Type : In Vitro Study

Additional Links

Substances : Oleanolic acid, Ursolic Acid

Diseases : Lung Cancer

Pharmacological Actions : Autophagy Inhibitors, Chemotherapeutic

[+]

Ursolic and oleanolic acids: plant metabolites with neuroprotective potential.Apr 26, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2021 Apr 27 ;22(9). Epub 2021 Apr 27. PMID: 33925641

Article Published Date : Apr 26, 2021

Study Type : Review

Additional Links

Substances : Oleanolic acid, Ursolic Acid

Diseases : Alzheimer's Disease, Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

Ursolic Acid jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 233 Abstracts with Ursolic Acid Research

Limited to Members Only

Currently Available Sorting Options

Anti-inflammatory and antioxidant activity of ursolic acidDec 31, 2022

Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment.Oct 04, 2023

Ursolic acid could affect the proliferation and apoptosis of human ovarian cancer stem-like cells and it is a potent anti-ovarian cancer agent.Oct 31, 2015

Ursolic acid enhances the sensitivity of MCF-7 and MDA-MB-231 cells to epirubicin.May 24, 2022

Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis.Nov 30, 2022

Ursolic acid alleviates mitotic catastrophe in podocyte by inhibiting autophagic P62 accumulation in diabetic nephropathy.Dec 31, 2023

Ursolic acid nanoparticles for glioblastoma therapy.May 31, 2023

Ursolic acid restores sensitivity to gemcitabine.Jan 14, 2021

Anti-inflammatory activity of ursolic acid in MPTP-induced parkinsonian mouse model.Apr 22, 2019

Anti-inflammatory and anti-oxidant role of ursolic acid in cerulein-induced acute pancreatitis.Dec 31, 2022

Anti-obesity and anti-diabetic effect of ursolic acid.Feb 02, 2022

Anxiolytic-like effects of ursolic acid in mice.Jul 04, 2015

C. officinalis may be used as a valuable food supplement for the treatment of diabetes mellitus.Jan 31, 2016

Dietary supplementation with 23-hydroxy ursolic acid reduces the severity and Incidence of acute experimental autoimmune encephalomyelitis.Jan 24, 2024

Dietary ursolic acid improves health span and life span in male Drosophila melanogaster.Feb 28, 2019

Effect of resistance and endurance training with ursolic acid on oxidative stress and cognitive impairment.Dec 31, 2022

Effects of ursolic acid on oxidative stress and inflammatory factors in a rat model of AR after PM2.5 exposure.Jul 06, 2022

Modulatory effect of ursolic acid on neurodegenerative activities in oxidative brain injury.Dec 22, 2020

Oleanolic acid and ursolic acid improve bone properties and calcium nalance and modulate vitamin D metabolism in aged female rats.Dec 31, 2017

Preventive effect of ursolic acid derivative on particulate matter 2.5-induced chronic obstructive pulmonary disease.Dec 15, 2019

Protective effect of ursolic acid on the intestinal mucosal barrier in a rat model of liver fibrosis.Dec 31, 2018

Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation.Aug 12, 2022

Research advances in protective effects of ursolic acid and oleanolic acid against gastrointestinal diseases.Feb 19, 2021

Rosemary and its constituents carnosol and ursolic acid inhibit skin cancer formation. Feb 01, 1994

Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis.Jan 30, 2021

Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy.Jan 07, 2020

Synergistic effect of ursolic acid and piperine in CCl 4 induced hepatotoxicity.Nov 30, 2021

Targeted delivery of ursolic acid and oleanolic acid to lungs in the form of an inhaler for the management of tuberculosis.Dec 31, 2021

The anti-arthritic effect of ursolic acid is comparable to ibuprofen in an animal model of arthritis, without causing gastric leasions. Oct 01, 2008

The combination of ursolic acid and empagliflozin relieves diabetic nephropathy.Oct 05, 2021

The combination treatment with ursolic acid and rosiglitazone ameliorated HFD-induced glucose intolerance and insulin resistance.May 31, 2016

The present findings indicated that ursolic acid may be a possible therapeutic agent against diabetic nephropathy.Oct 31, 2018

These data suggest that concurrent treatment with low-intensity exercise and ursolic acid is effective for atrophy-related physical dysfunctions.Jun 30, 2018

These results demonstrate a protective role of ursolic acid in ulcerative colitis.May 31, 2016

This work reveals the potential of ursolic acid as a promising treatment candidate for Parkinson's disease.Dec 11, 2015

Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress.Jan 03, 2021

Ursolic acid accelerates paclitaxel-induced cell death in esophageal cancer cells.Oct 24, 2021

Ursolic acid administered after irradiation greatly improved acute irradiation-induced deficits in contextual learning and memory.May 31, 2017

Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats.Jun 05, 2019

Ursolic acid alleviates cancer cachexia and prevents muscle wasting.Apr 19, 2023

Ursolic acid alleviates neuroinflammation after intracerebral hemorrhage..Sep 29, 2023

Ursolic acid alleviates tetrandrine-induced hepatotoxicity.Aug 31, 2022

Ursolic acid ameliorated the severity of abdominal aortic aneurysms.Feb 14, 2018

Ursolic acid ameliorates adipose tissue insulin resistance in aged rats.Nov 30, 2021

Ursolic acid ameliorates amyloid β-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome.Dec 31, 2021

Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms.Apr 30, 2023

Ursolic acid ameliorates inflammation in cerebral ischemia and reperfusion injury.Dec 31, 2017

Ursolic acid ameliorates myocardial ischaemia/reperfusion injury.Feb 19, 2023

Ursolic acid ameliorates obesity of mice fed with high-fat diet.Dec 31, 2022

Ursolic acid ameliorates spinal cord injury in mice by regulating gut microbiota.Dec 31, 2021

Ursolic acid ameliorates traumatic brain injury.Jun 30, 2023

Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum.Feb 25, 2022

Ursolic Acid and oleanolic acid reduced the proliferation of A549 cells in nude mice.Dec 31, 2015

Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta.Dec 31, 2021

Ursolic acid and tomatidine increased muscle mass and also increased musle strength in aged animals. Sep 02, 2015

Ursolic acid attenuated renal tubulointerstitial fibrosis by inhibiting epithelial-mesenchymal transition.Nov 30, 2019

Ursolic acid attenuates atherosclerosis in mice.May 06, 2018

Ursolic acid attenuates cigarette smoke induced rat emphysema.May 31, 2017

Ursolic acid can alleviate the memory impairments induced by Aβ25-35 in mice.May 31, 2016

Ursolic acid can be a good anti-cancer agent for targeted therapy or combination therapy with DNA damaging drugs for lung cancer patients.Dec 31, 2014

Ursolic acid can be the protective treatment for treatment of gestational diabetes mellitus. Feb 14, 2021

Ursolic acid can be used as a potential chemopreventive and therapeutic agent for gastric cancer.Sep 22, 2019

Ursolic acid can effectively inhibit the proliferation and migration and induce apoptosis of gastric cancer cells.Dec 31, 2018

Ursolic acid could attenuate cerebral ischemia and reperfusion injury.Dec 31, 2015

Ursolic acid could protect against liver damage from high intake of choline. Aug 23, 2016

Ursolic acid demonstrated its potential therapeutic utility to improve IR, hyperinsulinemia, and inflammation observed in obesity and diabetes.Nov 19, 2019

Ursolic acid derivatives as potential antidiabetic agents.Jan 28, 2018

Ursolic acid effectively ameliorated high fat diet induced hepatic steatosis.Dec 31, 2013

Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson's disease model.Sep 21, 2022

Ursolic acid enhances myelin repair in adult mice brains.Aug 16, 2022

Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in C. elegans serotonin-deficient mutants.Feb 16, 2021

Ursolic acid exhibits significant anti-tumor effects by suppressing cell proliferation, promoting apoptosis in gallbladder cancer cells. Dec 31, 2013

Ursolic Acid

View the Evidence:
233 Abstracts with Ursolic Acid Research