Vitamin B-12

Name	AC	CK
Vitamin B 12 Deficiency	47	364
High Homocysteine	16	153
Cognitive Decline/Dysfunction	8	72
Homocysteine: Elevated	8	64
Cardiovascular Diseases	4	50
Alzheimer's Disease	4	40
Depression	4	40
Dementia	5	34
Hyperhomocysteinemia	4	32
Vitamin B Deficiency	4	32
Cervical Cancer	3	30
Drug-Induced Nutrient Depletion: Vitamin B-12	3	30
Pancreatic Cancer	2	30
Schizophrenia	2	30
Vitamin D Deficiency	3	30
Cyanide Poisoning	6	26
Autism Spectrum Disorders	5	25
Multiple Sclerosis	5	24
Prostate Cancer	3	24
Folic Acid/Folate Deficiency	3	23
Obsessive-Compulsive Disorder	3	23
Oxidative Stress	3	22
Amyotrophic Lateral Sclerosis	3	21
Parkinson's Disease	3	21
Anemia	2	20
Anxiety	2	20
Atherosclerosis	2	20
Autoimmune Diseases	2	20
Cervical Dysplasia	2	20
Chronic Pelvic Pain Syndrome	2	20
Diabetes Mellitus: Type 2	2	20
Endothelial Dysfunction	2	20
Hepatitis A	2	20
Human Papillomavirus (HPV)	2	20
Hypertension	2	20
Incontinence: Double	1	20
Inflammation	2	20
Neurologic Disorders	2	20
Pregnancy Complications	2	20
Prostatitis: Chronic	2	20
Neurodegenerative Diseases	4	15
Anemia: Pernicious	2	13
Epilepsy	2	13
Aging	2	12
Air Pollution Linked Toxicity	2	12
Infertility: Female	2	12
Nicotine/Tobacco Toxicity	3	12
Peripheral Neuropathies	2	12
Psoriasis	3	12
Breast Cancer	2	11
Celiac Disease	2	11
Coronary Artery Disease	2	11
Diabetic Neuropathy	2	11
Smoking	2	11
Acid Reflux	1	10
Aging: Brain	1	10
Albuminuria: Pregnancy-Associated	1	10
Aphthous Ulcer	1	10
Arterial Calcification	1	10
Atopic Dermatitis	1	10
Autism	1	10
Biliary Cirrhosis	1	10
Buerger Disease	1	10
C-Reactive Protein	1	10
Canker Sore	1	10
Chemotherapy Induced Myelotoxicity	1	10
Chemotherapy-Induced Toxicity	1	10
Common variable immunodeficiency (CVID)	1	10
Constipation	1	10
Corticosteroid-Induced Toxicity	1	10
Cortisone Toxicity	1	10
Cystic Fibrosis	1	10
Dermatitis: Eczematous	1	10
Diabetes Mellitus: Type 1	1	10
Diabetes Mellitus: Type 2: Prevention	1	10
Diabetic Nephropathy	1	10
Diabetic Neuropathies	1	10
Diabetic bladder dysfunction	1	10
Eclampsia	1	10
Eczema	1	10
Elderly: Age Specific Diseases	1	10
Esophageal Cancer	1	10
Fibromyalgia	1	10
Gastroesophageal Reflux	1	10
Giant Cell Arteritis	1	10
Glaucoma	1	10
Headache	1	10
Hemodialysis	1	10
Hives	1	10
Homocystinuria	1	10
Hyperventilation	1	10
Hypothyroidism	1	10
Infant Care: Failure to Thrive	1	10
Infants: Low Birth Weight	1	10
Insulin Resistance	1	10
Iron Deficiency/Malabsorption	1	10
Leukoencephalopathy: Subcortical	1	10
Macular Degeneration	1	10
Metabolic Diseases	1	10
Metabolic Syndrome X	1	10
Migraine Disorders	1	10
Mucositis	1	10
Myelocognitive Disorder	1	10
Myeloneurocognitive Disorder	1	10
Myeloneuropathy	1	10
Myelopathy	1	10
Neurogenic Bladder	1	10
Neutropenia: Chemotherapy Induced	1	10
Peripheral Arterial Disease	1	10
Peripheral Vascular Diseases	1	10
Phenylketonurias	1	10
Placental abruption	1	10
Polymyalgia Rheumatica	1	10
Postpartum Depression	1	10
Pre-Eclampsia	1	10
Prediabetes	1	10
Prenatal Nutrition: Health of the Offspring	1	10
Pulmonary Embolism	1	10
Pulmonary Thromboembolism	1	10
Sarcopenia	1	10
Smoke Inhalation Poisoning	1	10
Smoking: Cardiovascular Disease	1	10
Spinal Cord Diseases	1	10
Spinal Cord Injuries	1	10
Stroke	1	10
Stroke: Attenuation/Recovery	1	10
Stroke: Hemorrhagic	1	10
Stroke: Ischemic	1	10
Thromboembolism	1	10
Thyrotoxicosis	1	10
Tinnitus	1	10
Trigeminal Neuralgia	1	10
Tuberculosis	1	10
Urticaria	1	10
Vitiligo	1	10
Wernicke Encephalopathy	1	10
Prenatal Chemical Exposures	2	4
Anemia: Megaloblastic	1	3
Fecal Incontinence	1	3
Gastric Surgery	1	3
Incontinence: Urinary	1	3
Neurodevelopmental Disorders	2	3
Neuropathic Pain	2	3
Psychotic Disorders	1	3
Thrombosis	1	3
Aerotoxic Syndrome	1	2
Alcohol Toxicity	1	2
Brain Inflammation	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Colon Cancer	1	2
Colorectal Cancer	2	2
Demyelinating Diseases	1	2
Endotoxemia	1	2
Feline Hyperthyroidism	1	2
Hydrogen Sulfide Toxicity	1	2
Hyperalgesia	1	2
Infertility: Male	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Memory Loss	1	2
Meningitis: Bacterial	1	2
Nerve Injuries	1	2
Neuropathies	1	2
Peripheral Nerve Diseases	1	2
Pneumococcal Infections	1	2
Vitamin A Deficiency	1	2
Acinetobacter baumannii infection	1	1
Brain: Oxidative Stress	1	1
Colorectal Cancer: Prevention	1	1
Coronavirus Disease	1	1
Coronavirus Infection	1	1
Drug Induced Toxicity: Ribavirin	1	1
Excitotoxicity	1	1
Gastrointestinal Diseases	1	1
Hearing Loss	1	1
Hepatitis C	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Inflammatory Bowel Diseases	1	1
Influenza	1	1
Liver Cancer	1	1
Low Back Pain	1	1
Malaria	1	1
Mitochondrial Dysfunction	1	1
Movement Disorders	1	1
Myocardial Infarction	1	1
Neuralgia	1	1
Neuroblastoma	1	1
Neurological Conditions	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Stem Cell Transplant	1	1
Stomatitis: Aphthous	1	1
Tobacco Toxicity	1	1

Name	AC	CK
Neuroprotective Agents	16	75
Anti-Inflammatory Agents	12	62
Antioxidants	9	56
Chemopreventive	3	40
Analgesics	4	22
Cardioprotective	3	22
Anticonvulsants	2	20
Antidepressive Agents	2	20
Hypoglycemic Agents	2	20
Interleukin-6 Downregulation	2	20
Renoprotective	2	20
Tumor Necrosis Factor (TNF) Alpha Inhibitor	2	12
Anti-Ulcer Agents	1	10
Antineoplastic Agents	1	10
Chemotherapeutic	1	10
Cytoprotective	1	10
Interleukin-2 Downregulation	1	10
Interleukin-6 upregulation	1	10
MicroRNA modulator	1	10
Proton Pump Inhibitor	1	10
Vasodilator Agents	1	10
Vasoprotective	1	10
Antiproliferative	1	2
Fertility Agents: Male	1	2
Immunomodulatory	2	2
Interleukin-1 beta downregulation	1	2
NF-kappaB Inhibitor	1	2
Regenerative	1	2
Antimalarials	1	1
Antimicrobial	1	1
Antiviral Agents	1	1
Apoptotic	1	1
Gastrointestinal Agents	1	1
Remyelination	1	1

[+]

Certain vitamin and mineral supplements may reduce psychiatric symptoms in some people with schizophrenia.Feb 15, 2017

Click here to read the entire abstract

Pubmed Data : Psychol Med. 2017 Feb 16:1-13. Epub 2017 Feb 16. PMID: 28202095

Article Published Date : Feb 15, 2017

Study Type : Meta Analysis, Review

Additional Links

Substances : Vitamin B-12, Vitamin B-6

Diseases : Schizophrenia

[+]

Click here to read the entire abstract

Pubmed Data : Dermatology. 2001;203(2):141-7. PMID: 11586013

Article Published Date : Jan 01, 2001

Study Type : Human Study

Additional Links

Substances : Avocado, Vitamin B-12

Diseases : Psoriasis

[+]

Pubmed Data : Zhongguo Zhen Jiu. 2007 Sep;27(9):668-70. PMID: 17926620

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Am Heart Assoc. 2018 May 18 ;7(11). Epub 2018 May 18. PMID: 29776960

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Oct 23 ;12(11). Epub 2020 Oct 23. PMID: 33114210

Article Published Date : Oct 22, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antiinflamm Antiallergy Agents Med Chem. 2019 ;18(2):151-161. PMID: 30488800

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Folic Acid , Pollen: Flower, Riboflavin (Vitamin B-2), Saw Palmetto, Thiamine (B-1) , Vitamin B-12, Vitamin B-6

Diseases : Chronic Pelvic Pain Syndrome, Prostatitis: Chronic

Pharmacological Actions : Analgesics

Additional Keywords : Plant Extracts

[+]

Folate and vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids.Jan 17, 2017

Article Published Date : Feb 13, 2022

Study Type : Human Study

Additional Links

Substances : Folic Acid , Vitamin B-12

Diseases : Septic Shock

[+]

Click here to read the entire abstract

Pubmed Data : Ophthalmic Res. 2008;40(5):249-56. Epub 2008 Apr 25. PMID: 18437035

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Folic Acid , Vitamin B-12, Vitamin B-6

Diseases : Glaucoma, High Homocysteine

[+]

Homocysteine-lowering therapy may prevent bone loss in Parkinson's disease patients taking levodopa.Feb 15, 2010

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Pubmed Data : Mov Disord. 2010 Feb 15;25(3):332-40. PMID: 19938151

Article Published Date : Feb 15, 2010

Pubmed Data : J Clin Endocrinol Metab. 2019 Oct 1 ;104(10):4837-4847. PMID: 30920623

Article Published Date : Sep 30, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Additional Keywords : Risk Factors

Problem Substances : Metformin

[+]

Hyperhomocysteinaemia, vascular related pregnancy complications respond favorably to vitamin supplementation in pregnant women of Pakistan.Sep 01, 2010

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Pubmed Data : J Pak Med Assoc. 2010 Sep;60(9):741-5. PMID: 21381582

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : B-complex, Vitamin B-12, Vitamin B-6

Diseases : Albuminuria: Pregnancy-Associated, Eclampsia, High Homocysteine, Infants: Low Birth Weight, Placental abruption, Pre-Eclampsia, Pregnancy Complications

[+]

Improvement of executive function after short-term administration of an antioxidants mix.Dec 26, 2020

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Pubmed Data : Nutrients. 2020 Dec 27 ;13(1). Epub 2020 Dec 27. PMID: 33375429

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Pubmed Data : Pharmacogenet Genomics. 2009 Jun;19(6):422-8. PMID: 19384265

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Folic Acid , Vitamin B-12, Vitamin B-6

Diseases : High Homocysteine, Migraine Disorders

Additional Keywords : Diseases that are Linked

[+]

Methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. May 01, 2010

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Pubmed Data : J Altern Complement Med. 2010 May;16(5):555-60. PMID: 20804367

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Gerontol A Biol Sci Med Sci. 2016 Feb ;71(2):236-42. Epub 2015 Aug 11. PMID: 26265727

Article Published Date : Jan 31, 2016

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Pubmed Data : Eur J Clin Invest. 1997 Sep;27(9):723-30. PMID: 9352241

Article Published Date : Sep 01, 1997

Study Type : Human Study

Additional Links

Substances : beta-Carotene, Folic Acid , Vitamin B-12, Vitamin E

Diseases : Common variable immunodeficiency (CVID) , High Homocysteine

Additional Keywords : Diseases that are Linked

[+]

Plasma vitamin B12 concentration is positively associated with cognitive development in healthy Danish 3-year-old children.Dec 15, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Nutr. 2021 Dec 16:1-25. Epub 2021 Dec 16. PMID: 34913420

Article Published Date : Dec 15, 2021

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Childhood Cognitive Disorders, Vitamin B 12 Deficiency

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Factors

[+]

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

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Pubmed Data : Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642

Article Published Date : Apr 01, 1983

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Acid Reflux, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Pharmacological Actions : Anti-Ulcer Agents

Problem Substances : Histamine Receptor Antagonists, Ranitidine

[+]

Sarcopenia might be related to vitamin B12 deficiency.Aug 31, 2017

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Pubmed Data : Exp Gerontol. 2017 Sep ;95:136-140. Epub 2017 May 23. PMID: 28549839

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neurology. 2020 03 17 ;94(11):e1112-e1121. Epub 2020 Feb 26. PMID: 32102976

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sultan Qaboos Univ Med J. 2020 Feb ;20(1):e90-e94. Epub 2020 Mar 9. PMID: 32190375

Article Published Date : Jan 31, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Additional Keywords : Risk Factors

Problem Substances : Metformin

[+]

The results of the study show that vitamin B12 deficiency or insufficiency and elevated homocysteine may contribute to the etiopathogenesis of depression. Apr 17, 2020

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Pubmed Data : Child Adolesc Ment Health. 2020 Apr 18. Epub 2020 Apr 18. PMID: 32304285

Article Published Date : Apr 17, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Depression, Homocysteine: Elevated, Vitamin B 12 Deficiency

Additional Keywords : Increased Risk

[+]

Click here to read the entire abstract

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Pubmed Data : Clin Nutr. 2019 Jan 17. Epub 2019 Jan 17. PMID: 30704890

Article Published Date : Jan 16, 2019

Study Type : Human Study

Additional Links

Substances : B-complex, Thiamine (B-1) , Vitamin B-12, Vitamin B-6

Diseases : Diabetes Mellitus: Type 1, Diabetic Nephropathy, Homocysteine: Elevated

Pharmacological Actions : Hypoglycemic Agents, Renoprotective

[+]

Vitamin B1 and mecobalamin are potential treatment options for patients with dry eye disease.Sep 10, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Sep 11 ;14(18). Epub 2022 Sep 11. PMID: 36145126

Article Published Date : Sep 10, 2022

Study Type : Human Study

Additional Links

Substances : Thiamine (B-1) , Vitamin B-12

Diseases : Dry Eye Syndromes

Pharmacological Actions : Neuroprotective Agents

[+]

Vitamin B12 and acupuncture have therapeutic value in treating diabetic neurogenic bladder. Jul 01, 2007

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Pubmed Data : Zhongguo Zhen Jiu. 2007 Jul;27(7):485-7. PMID: 17722823

Click here to read the entire abstract

Pubmed Data : J Spinal Cord Med. 2003;26(2):116-21. PMID: 12828286

Click here to read the entire abstract

Pubmed Data : Acta Psychiatr Scand. 1988 Jul;78(1):8-10. PMID: 3176999

Article Published Date : Jul 01, 1988

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Obsessive-Compulsive Disorder, Vitamin B 12 Deficiency

[+]

Additional Keywords : Increased Risk, Risk Factors

[+]

Vitamin B12 supplementation resulted in improved cognitive function.Apr 01, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Apr 2 ;14(7). Epub 2022 Apr 2. PMID: 35406106

Article Published Date : Apr 01, 2022

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Cognitive Decline/Dysfunction, Vitamin B 12 Deficiency

Pharmacological Actions : Neuroprotective Agents

[+]

Vitamin B12 treatment reduces homocysteine in patients with mild hyperhomocysteinemia. Nov 01, 2002

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Pubmed Data : Ceska Slov Farm. 2002 Nov;51(6):310-2. PMID: 12501494

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Pubmed Data : BMJ Case Rep. 2019 May 14 ;12(5). Epub 2019 May 14. PMID: 31092496

Article Published Date : May 13, 2019

Study Type : Human: Case Report

Additional Links

Substances : Vitamin B-12

Diseases : Dementia, Epilepsy, Psychotic Disorders, Vitamin B 12 Deficiency

[+]

Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.Jul 08, 2022

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Pubmed Data : J Hepatol. 2022 Jul 9. Epub 2022 Jul 9. PMID: 35820507

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Pubmed Data : Biol Reprod. 2009 Apr;80(4):743-52. Epub 2008 Dec 10. PMID: 19074000

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Methionine, Vitamin B-12

Diseases : Infertility: Female

[+]

A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice.Nov 01, 2001

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Pubmed Data : Carcinogenesis. 2001 Nov;22(11):1871-5. PMID: 11698351

Article Published Date : Nov 01, 2001

Study Type : Animal Study

Additional Links

Substances : Folic Acid , Methionine, Vitamin B-12

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative

Anti Therapeutic Actions : Western Diet

[+]

Administration of Vitamin C, Vitamin B12, omega 3, or their combination prior to the lead exposure inhibits the lead induced cognitive loss.Sep 30, 2016

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Pubmed Data : Res Pharm Sci. 2016 Oct ;11(5):390-396. PMID: 27920821

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Pubmed Data : Ideggyogy Sz. 2020 Mar 30 ;73(3-4):113-120. PMID: 32364338

Article Published Date : Mar 29, 2020

Study Type : Animal Study

Additional Links

Substances : Vitamin B-12, Vitamin D

Diseases : Peripheral Neuropathies

Pharmacological Actions : Regenerative

Additional Keywords : Natural Substance Synergy, Nerve Regeneration

[+]

Gestational B-vitamin supplementation alleviates PM2.5-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring.Dec 14, 2019

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Pubmed Data : Ecotoxicol Environ Saf. 2019 Dec 15 ;185:109686. Epub 2019 Sep 20. PMID: 31546205

Article Published Date : Dec 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Occup Health. 2004 Sep ;46(5):359-64. PMID: 15492452

Article Published Date : Aug 31, 2004

Study Type : Animal Study

Additional Links

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Pubmed Data : Hepatology. 1997 Dec;26(6):1538-45. PMID: 17548438

Article Published Date : Dec 01, 1997

Study Type : Animal Study

Additional Links

Substances : Vitamin B-12

Diseases : Demyelinating Diseases, Multiple Sclerosis

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

The use of dietary supplements in children with autism seems to be a safe practice with encouraging data about their clinical efficacy.Apr 20, 2017

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Pubmed Data : Brain Dev. 2017 Apr 21. Epub 2017 Apr 21. PMID: 28438367

Article Published Date : Apr 20, 2017

Study Type : Review

Additional Links

Substances : Amino Acids, Essential Fatty Acids, Magnesium, Vitamin B-12, Vitamin C

Diseases : Autism Spectrum Disorders

[+]

Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 from the SARS-CoV-2 virus.Aug 17, 2020

[+]

Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress-dependent neuronal death.May 24, 2020

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Pubmed Data : J Cell Biochem. 2020 May 25. Epub 2020 May 25. PMID: 32449987

Article Published Date : May 24, 2020

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin, Bacopa, Lycopene, Vitamin B-12

Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity, Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections.Apr 22, 2020

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Pubmed Data : Nutrients. 2020 Apr 23 ;12(4). Epub 2020 Apr 23. PMID: 32340216

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Pubmed Data : Clin Dermatol. 2010 Nov-Dec;28(6):615-26. PMID: 21034986

Article Published Date : Oct 31, 2010

The relationship between folate, vitamin B12 and gestational diabetes mellitus.Aug 31, 2021

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Pubmed Data : J Family Reprod Health. 2021 Sep ;15(3):141-149. PMID: 34721605

Article Published Date : Aug 31, 2021

Study Type : Review

Additional Links

Substances : Folate, Vitamin B-12

Diseases : Folic Acid/Folate Deficiency, Gestational Diabetes, Vitamin B 12 Deficiency

Pharmacological Actions : Antioxidants

Additional Keywords : Risk Factors

[+]

The removal of cyanide from the cyanocobalamin form of vitamin B12 depends on a trafficking chaperone, which may not exist in certain individuals and who would respond better to aquocobalamin. Jan 01, 1997

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Pubmed Data : Biomed Pharmacother. 1997;51(9):397-403. PMID: 18779575

Article Published Date : Jan 01, 1997

Study Type : Commentary

Additional Links

Substances : Vitamin B-12

Diseases : Cyanide Poisoning

[+]

This synergistic action of vitamins with the antibiotics can be used as a tool to treat multiple drug resistant super bugs.Feb 01, 2018

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Pubmed Data : J Glob Antimicrob Resist. 2018 Feb 2. Epub 2018 Feb 2. PMID: 29408383

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Pubmed Data : Tumour Biol. 2022 ;44(1):17-35. PMID: 35180142

Article Published Date : Dec 31, 2021

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Pubmed Data : Cell Rep. 2020 Mar 24 ;30(12):3981-3988.e3. PMID: 32209461

Article Published Date : Mar 23, 2020

Study Type : In Vitro Study

Additional Links

Substances : Vitamin B-12

Diseases : Neurodevelopmental Disorders, Vitamin B 12 Deficiency

Pharmacological Actions : Neuroprotective Agents

[+]

Methylcobalamin inhibits the proliferation of malignant cells. - Article 1Jan 01, 1997

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Pubmed Data : Int J Vitam Nutr Res. 1997;67(3):164-70. PMID: 9202976

Article Published Date : Jan 01, 1997

Additional Links

Substances : Vitamin B-12

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View the Evidence: 194 Abstracts with Vitamin B-12 Research

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Certain vitamin and mineral supplements may reduce psychiatric symptoms in some people with schizophrenia.Feb 15, 2017

Folic aicd combined with vitamin B6 and B12 treatment significantly reduced plasma homocysteine levelMay 31, 2015

Lower vitamin B12 levels are associated with increased rates of double incontinence.Sep 01, 2002

This meta-analysis found that vitamin intake can decrease the risk of pancreatic cancer.Feb 28, 2018

Vitamin B supplementation was effective in reducing serum homocysteine levels.Dec 31, 2016

High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis.Dec 31, 2019

5-methyltehydrofolate (folic acid) and vitamin B12 ameliorate red blood cell abnormalities in pediatric patients with Cystic Fibrosis. Jan 01, 2009

A B12 cream containing avocado oil has potential for the treatment of psoriasis,Jan 01, 2001

A blue-green algae product improves vitamin B12 status and reduces homocysteine.Oct 01, 2005

A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Dec 31, 2011

A combination of gastrodin, folate, and vitamin-B12 in addition to standard antiepileptic treatment can effectively control epileptic seizures.Oct 31, 2017

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

A multi-vitamin/nutrient formula has therapeutic value in moderate-stage to later-stage Alzheimer's diease. Feb 01, 2009

Abnormalities in the immune system in pernicious anemia are restored by vitamin B(12) replacement therapy.Jan 01, 2008

Acupoint injection of Vit B12 has a superior therapeutic effect than the drug Carbamazepine in the treatment of trigeminal neuralgia. Sep 01, 2007

Add-on supplementation with vitamin B12 improved glycaemic control and insulin resistance in patients with type 2 diabetes mellitus.Aug 31, 2020

Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis.Feb 01, 2004

Association of vitamin D and vitamin B12 with cognitive impairment in elderly aged 80 years or older.Feb 27, 2019

Associations of dietary vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12 and folate equivalent intakes with metabolic syndrome.Jan 26, 2020

B vitamins appear to slow cognitive and clinical decline in people with mild cognitive impairment, in particular in those with elevated homocysteine.Jul 21, 2011

B vitamins attenuate the epigenetic effects of ambient fine particles.Mar 12, 2017

B vitamins could be used to improve mood symptoms and mental health quality of life in adults with depression.Dec 31, 2012

B12 supplementation influences regulation of several metabolically important Type 2 diabetes-associated genes through methylation of miR21.Nov 13, 2017

Beneficial effects of pollen extract in association with vitamins for pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome.Apr 23, 2013

Better B-vitamin status may have a role in impacting positively on mental health in older adults. Jan 24, 2019

Chronic idiopathic urticaria is associated with low levels of vitamin B12 and concomitant autoimmunity. Jan 01, 2004

Circulating vitamin B12 levels are inversely associated with HPV persistence. Apr 01, 2002

Coenzyme-b12 is more effective than cyanocobalamin in normalizing liver enzymes in patients with acute viral hepatitis A. Jan 01, 1977

Combined treatment with folic acid, vitamin B6, and vitamin B12 lowers homocysteine concentrations.May 17, 2018

Cyanide-containing B12 (Cyanocobalamin) inhibits natural vitamin B12 and causes cytotoxicity.Jun 15, 1997

Cyanocobalamin demonstrates therapeutic activity against aphthous ulcers (canker sores).Nov 01, 2008

Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy.Oct 22, 2020

Elevated homocysteine levels associated with polymyalgia rheumatica and giant cell arteritis and the corticosteroid therapy used to treat these conditions may be attenuated with vitamin B12 and folic acid. Sep 01, 2003

Elevated homocysteine levels in the cerebrospinal fluid of patients with fibromyalgia and chronic fatigue syndrome is probably due in part to vitamin b12 deficiency. Jan 01, 1997

Failure to thrive in infants may be related to to occult maternal pernicious anemia.May 01, 2010

Flower pollen extract in association with vitamins versus Serenoa repens in chronic prostatitis/chronic Pelvic pain syndrome.Dec 31, 2018

Folate and vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids.Jan 17, 2017

Folate and vitamin B12 lower homocysteine concentrations in hemodialysis patients.Sep 01, 2009

Folate, riboflavin, thiamin and vitamin b12 protect against premalignant cervical lesions.Nov 01, 2003

Folate, vitamin B-12 and vitamin B-6 intake were inversely associated with the risk of diabetes in US adults.Dec 31, 2020

Folic acid and vitamin B(12) supplementation improves vascular endothelial function in patients with coronary heart disease. Nov 14, 2000

Folic acid and vitamin B12 as biomarkers of morbidity and mortality in patients with septic shock.Feb 13, 2022

Folic acid supplementation mitigates Alzheimer's disease by reducing inflammation.Dec 31, 2015

Higher consumption of folate may contribute to the prevention of peripheral arterial disease. Sep 01, 2003

Higher dietary intakes of folate and vitamin B6 were significantly associated with lower all-cause and cardiovascular mortality.May 26, 2022

Higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs).Jan 01, 2010

Higher vitamin B12 level at Parkinson's disease diagnosis is associated with lower risk of future dementia.Mar 15, 2020

Homocysteine levels in the tear fluid and plasma of patients with primary open-angle glaucoma is often elevated, indicating that inadequate vitamin b levels (e.g. b6, b12, and folate) may contribute to the disease.Jan 01, 2008

Homocysteine-lowering therapy may prevent bone loss in Parkinson's disease patients taking levodopa.Feb 15, 2010

Hydroxocobalamin has a therapeutic effect in acute cyanide poisoning in smoke inhalation. Jun 01, 2007

Hydroxocobalamin is a cyanide antidote.Jan 01, 1993

Hyperglycemia and metformin use are associated With B vitamin deficiency and cognitive dysfunction in older adults.Sep 30, 2019

Hyperhomocysteinaemia, vascular related pregnancy complications respond favorably to vitamin supplementation in pregnant women of Pakistan.Sep 01, 2010

Improvement of executive function after short-term administration of an antioxidants mix.Dec 26, 2020

L-arginine, folic acid, B6 and B12 may have therapeutic benefit in Buerger's disease. Oct 01, 2006

Leukoencephalopathy may respond to vitamin b-12 therapy despite normal pretreatment serum levels.Jun 28, 2010

Low serum concentrations of vitamin B6 and iron are related to panic attack and hyperventilation attack.Dec 31, 2012

Low serum vitamin B12 levels are independently associated with abnormal lipid profiles in healthy young Saudi women.Aug 09, 2020

Low vitamin B12 levels: An underestimated cause Of minimal cognitive impairment and dementia.Feb 12, 2020

Lowering homocysteine with folic acids, B-6 and B-12 may have a therapeutic effect on migraine headaches. Jun 01, 2009

Methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. May 01, 2010

Methylcobalamin (vitamin B-12) and a form of folic acid (folinic acid) may have clinical benefit for some children with autism. Dec 05, 2005

Methylcobalamin may prevent muscle wasting in amyotrophic lateral sclerosis.Dec 01, 1998

Moderate consumption of riboflavin may be protective against postpartum depression.Jul 31, 2000

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Oat-bran helps to improve constipation management and B12 bioavailability in elderly, with multiple chronic diseases who live in nursing homes.Mar 01, 2010

Oral vitamin B12 is as effective intramuscular injection for the treatment of megaloblastic anemia. Dec 01, 2003

Patients with common variable immunodeficiency have enhanced oxidative stress and high homocysteine levels associated with deficiencies of basic vitamins is Sep 01, 1997

Plasma vitamin B12 concentration is positively associated with cognitive development in healthy Danish 3-year-old children.Dec 15, 2021

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

Sarcopenia might be related to vitamin B12 deficiency.Aug 31, 2017

Significantly lower levels of vitamin B12 and vitamin D and higher levels of homocysteine were found in people with OCD.Dec 31, 2016

Vitamin B-12

View the Evidence:
194 Abstracts with Vitamin B-12 Research