Vitamin K2

Views 12052
Jump to
Abstracts Focused Research Topics
Download the GMI DOC on this Topic

Focus Your Research

Click any topic below to filter + focus research
64 Diseases Researched for Vitamin K2
NameACCKFocus
Osteoporosis26172Locked
Bone Fractures985Locked
Coronary Artery Disease451Locked
Liver Cancer634Locked
Arterial Hardening: Elasticity330Locked
Cardiac Mortality 230Locked
Postmenopausal Disorders230Locked
Vitamin K Deficiency322Locked
Cardiovascular Diseases321Locked
Aortic Calcification120Locked
Arteriosclerosis120Locked
C-Reactive Protein220Locked
Liver Cirrhosis120Locked
Mortality: All-Cause120Locked
Myocardial Infarction120Locked
Organ Transplantation120Locked
Organ Transplantation: Heart120Locked
Organ Transplantation: Lung120Locked
Prostate Cancer: Prevention120Locked
Rheumatoid Arthritis220Locked
Diabetes Mellitus: Type 2515Locked
Arterial Calcification414Locked
Atherosclerosis314Locked
Cancers: All312Locked
Osteopenia212Locked
All-Cause Mortality110Locked
Anemia: Aplastic110Locked
Athletic Performance110Locked
Cancer Mortality110Locked
Cerebral Palsy110Locked
Corticosteroid-Induced Toxicity110Locked
Hip Fracture110Locked
Multiple Sclerosis110Locked
Myelodysplastic Syndrome110Locked
Obesity110Locked
Osteoporosis: Steroid-Induced110Locked
Thrombocytopenia110Locked
Osteonecrosis26Locked
Atopic Dermatitis15Locked
Aging24Locked
Breast Cancer: Triple Negative 33Locked
Prostate Cancer23Locked
Anxiety12Locked
Breast Cancer22Locked
Chronic Kidney Disease (CKD)12Locked
Colon Cancer12Locked
Depression12Locked
Diabetic Complications12Locked
Endothelial Dysfunction12Locked
Lymphoma12Locked
Metabolic Syndrome X12Locked
Acute Myeloid Leukemia11Locked
Arthritis11Locked
Bladder Cancer11Locked
Cancers: Radiation-Resistant11Locked
Coronavirus Infection11Locked
Diabetes: Bone Quality & Density11Locked
Hypercalcemia11Locked
Hypoxia11Locked
Inflammation11Locked
Mitochondrial Diseases11Locked
Mitochondrial Dysfunction 11Locked
Neurodegenerative Diseases11Locked
Parkinson's Disease11Locked
30 Pharmacological Actions Researched for Vitamin K2
NameACCKFocus
Cardioprotective340Locked
Osteoprotective 533Locked
Anti-Inflammatory Agents423Locked
Anticarcinogenic Agents222Locked
Hepatoprotective120Locked
Matrix metalloproteinase-3 (MMP-3) inhibitor220Locked
Antiproliferative 615Locked
Anti-atherogenic314Locked
Apoptotic56Locked
NF-kappaB Inhibitor46Locked
Immunosuppressive Agents15Locked
MicroRNA modulator15Locked
Osteogenic15Locked
Chemopreventive24Locked
Antineoplastic Agents33Locked
Angiogenesis Inhibitors12Locked
Anti-Anxiety Agents12Locked
Anti-metastatic12Locked
Antidepressive Agents12Locked
Hypoglycemic Agents12Locked
Renoprotective12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Anti-Apoptotic11Locked
Cell cycle arrest11Locked
Chemosensitizer11Locked
Chemotherapeutic11Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor11Locked
Immunomodulatory11Locked
Neuroprotective Agents11Locked
Radiosensitizer11Locked
Related Topics

The Following are Sub-Topics of Vitamin K2

Vitamin K2 is a Sub of the following Topic

View the Evidence:
76 Abstracts with Vitamin K2 Research

[+]

High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women.Apr 01, 2009

Pubmed Data : Nutr Res. 2009 Apr;29(4):221-8. PMID: 19410972
Article Published Date : Apr 01, 2009
Study Type : Meta Analysis
Additional Links
Substances : Vitamin K, Vitamin K2
Diseases : Bone Fractures, Osteoporosis, Postmenopausal Disorders
[+]

Vitamin K1 and K2 exhibit anti-fracture activity.Dec 01, 2009

Pubmed Data : Clin Calcium. 2009 Dec;19(12):1805-14. PMID: 19949272
Article Published Date : Dec 01, 2009
Study Type : Meta Analysis
Additional Links
Substances : Vitamin K2
Diseases : Bone Fractures, Osteoporosis
[+]

A high vitamin K2 (menaquinone) intake reduces the incidence of coronary heart disease.Sep 01, 2009

Pubmed Data : Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):504-10. Epub 2009 Jan 28. PMID: 19179058
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin K2, Vitamin K2: (MK-8), Vitamin K2: (MK-9), Vitamin K2: Menaquinone-7
Diseases : Coronary Artery Disease
[+]

A vitamin K2 preparation inhibits the development of liver cancer in patients with type C cirrhosis. Sep 01, 2010

Pubmed Data : Hepatogastroenterology. 2010 Sep-Oct;57(102-103):1264-7. PMID: 21410069
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Menatetrenone, Vitamin K2, Vitamin K2: Menaquinones (MK-4-14)
Diseases : Liver Cancer, Liver Cirrhosis
Pharmacological Actions : Anticarcinogenic Agents, Hepatoprotective
[+]

Adding vitamin K(2) to vitamin D(3) with calcium reduced the lifetime probability ofat least one fracture by 25%, increased discounted survival by 0.7 quality-adjusted life-years (QALYs). Mar 08, 2012

Pubmed Data : Osteoporos Int. 2012 Mar 8. Epub 2012 Mar 8. PMID: 22398856
Article Published Date : Mar 08, 2012
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Bone Fractures
[+]

An increase in dietary intake of vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr. 2014 May ;144(5):743-50. Epub 2014 Mar 19. PMID: 24647393
Article Published Date : Apr 30, 2014
Study Type : Human Study
Additional Links
Substances : Vitamin K, Vitamin K2
Diseases : All-Cause Mortality, Cancer Mortality, Cancers: All, Cardiac Mortality , Cardiovascular Diseases, Diabetes Mellitus: Type 2
Additional Keywords : All-Cause Mortality, Cancer Mortality, Cancers: All, Cardiac Mortality, Cardiovascular Diseases, Diabetes mellitus: Type 2, Risk Reduction, Vitamin K, Vitamin K2
[+]

Aterofisiol showed to be effective in reducing the amounts of cholesterol and lipids in the plaques and in reducing adverse neurological events.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2015 ;9:3877-84. Epub 2015 Jul 23. PMID: 26229448
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Resveratrol, Vitamin B12, Vitamin B6, Vitamin K2
Diseases : Carotid Stenosis
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
Additional Keywords : Proanthocyanidins
[+]

Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease, cardiac mortality, aortic calcification and all-cause mortality. Nov 01, 2004

Pubmed Data : J Nutr. 2004 Nov;134(11):3100-5. PMID: 15514282
Article Published Date : Nov 01, 2004
Study Type : Human Study
Additional Links
Substances : Vitamin K, Vitamin K2, Vitamin K2: Menaquinone-7
Diseases : Aortic Calcification, Arteriosclerosis, Cardiac Mortality , Coronary Artery Disease, Mortality: All-Cause, Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Dietary vitamin K2 supplement improves bone status after lung and heart transplantation.Feb 27, 2010

Pubmed Data : Transplantation. 2010 Feb 27;89(4):458-64. PMID: 20177349
Article Published Date : Feb 27, 2010
Study Type : Human Study
Additional Links
Substances : Vitamin K2, Vitamin K2: Menaquinone-7
Diseases : Organ Transplantation, Organ Transplantation: Heart, Organ Transplantation: Lung, Osteoporosis
[+]

High dietary menaquinone (Vitamin K2) intake is associated with reduced coronary calcification.Apr 01, 2009

Pubmed Data : Atherosclerosis. 2009 Apr;203(2):489-93. Epub 2008 Jul 19. PMID: 18722618
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : Menaquinone , Vitamin K2
Diseases : Arterial Calcification, Cardiovascular Diseases, Coronary Artery Disease
Pharmacological Actions : Cardioprotective
[+]

Levels of menaquinone-7 and vitamin D are lower in those wtih hip fracture, indicating they may have a role in fracture prevention.Jan 01, 2011

Pubmed Data : Asia Pac J Clin Nutr. 2011;20(1):56-61. PMID: 21393111
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Vitamin D, Vitamin K2: Menaquinone-7
Diseases : Hip Fracture
[+]

Long-term use of MK-7 supplements improves arterial stiffness in healthy postmenopausal women, especially in women having a high arterial stiffness.Apr 30, 2015

Pubmed Data : Thromb Haemost. 2015 May ;113(5):1135-44. Epub 2015 Feb 19. PMID: 25694037
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin K2: Menaquinone-7
Diseases : Arterial Hardening: Elasticity
[+]

Menaquinone-7 (vitamin K2) supplementation increases osteocalcin carboxylation associated with improved bone quality.Oct 01, 2009

Pubmed Data : Br J Nutr. 2009 Oct;102(8):1171-8. Epub 2009 May 19. PMID: 19450370
Article Published Date : Oct 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin K2: Menaquinone-7
Diseases : Bone Fractures, Osteoporosis
[+]

MK-7 in addition to ordinary meals could improve osteocalcin γ-carboxylation status.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2015 ;61(6):471-80. PMID: 26875489
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Vitamin K2: Menaquinone-7
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Oral consumption of vitamin K2 for 8 weeks associated with increased maximal cardiac output during exercise.Jun 30, 2017

Pubmed Data : Altern Ther Health Med. 2017 Jul ;23(4):26-32. PMID: 28646812
Article Published Date : Jun 30, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Athletic Performance
Therapeutic Actions : Exercise
[+]

Supplementing sorafenib with vitamin K may produce synergistic therapeutic effects against hepatocellular carcinoma.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Hepatobiliary Pancreat Surg. 2015 Feb ;19(1):1-5. Epub 2015 Feb 28. PMID: 26155269
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: Sorafenib, Significant Treatment Outcome
[+]

The consumption of vitamin K2 rich fermented soybean food products may contribute to the relatively lower fracture risk of Japanese women. Apr 01, 2001

Pubmed Data : Nutrition. 2001 Apr;17(4):315-21. PMID: 11369171
Article Published Date : Apr 01, 2001
Study Type : Human Study
Additional Links
Substances : Fermented Foods and Beverages, Natto , Soy, Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Osteoporosis
Additional Keywords : Risk Reduction
[+]

There is an inverse association between the intake of menaquinones and prostate cancer.Apr 01, 2008

Pubmed Data : Am J Clin Nutr. 2008 Apr;87(4):985-92. PMID: 18400723
Article Published Date : Apr 01, 2008
Study Type : Human Study
Additional Links
Substances : Vitamin K, Vitamin K2, Vitamin K2: Menaquinones (MK-4-14)
Diseases : Prostate Cancer: Prevention
[+]

These results suggest that menaquinone-7 improves disease activity in patients with rheumatoid arthritis.Aug 14, 2015

Pubmed Data : Eur J Pharmacol. 2015 Aug 15 ;761:273-8. Epub 2015 Jun 11. PMID: 26073022
Article Published Date : Aug 14, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin K2: Menaquinone-7
Diseases : C-Reactive Protein, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-3 (MMP-3) inhibitor
Additional Keywords : Significant Treatment Outcome
[+]

This clinical study reported the advantageous effect of Menaquinone-7 administration on depression status in PCOS patients.Jan 25, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Womens Health. 2022 07 26 ;22(1):315. Epub 2022 Jul 26. PMID: 35883082
Article Published Date : Jan 25, 2022
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Depression, Polycystic Ovary Syndrome
Pharmacological Actions : Antidepressive Agents
[+]

Vitamin D3 and vitamin K2 have a therapeutic effect on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.May 01, 2008

Pubmed Data : J Nutr. 2008 May;138(5):954-63. PMID: 11180916
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Substances : Vitamin D, Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Osteoporosis
[+]

Vitamin K-induced effects on body fat and weight.Dec 31, 2017

Pubmed Data : Eur J Clin Nutr. 2018 Jan ;72(1):136-141. Epub 2017 Sep 27. PMID: 28952607
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin K2: Menaquinone-7
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Vitamin K2 (MK-4) may be beneficial in the maintenance of bone health in postmenopausal women.Feb 01, 2009

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21. PMID: 19352059
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin K2, Vitamin K2: (MK-4)
Diseases : Bone Fractures, Osteoporosis, Postmenopausal Disorders
[+]

Vitamin K2 administration may reduce the progression of atherosclerosis.Jul 14, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pol Arch Med Wewn. 2015 Jul 15. Epub 2015 Jul 15. PMID: 26176325
Article Published Date : Jul 14, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

Vitamin K2 had a positive effect on bone mineral density in osteoporotic adults with cerebral palsy.Jun 13, 2017

Pubmed Data : Brain Dev. 2017 Jun 14. Epub 2017 Jun 14. PMID: 28624135
Article Published Date : Jun 13, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Cerebral Palsy, Osteoporosis
[+]

Vitamin K2 improves disease activity in rheumatoid arthritis. Nov 05, 2012

Pubmed Data : Mod Rheumatol. 2012 Nov 6. Epub 2012 Nov 6. PMID: 23124653
Article Published Date : Nov 05, 2012
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : C-Reactive Protein, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-3 (MMP-3) inhibitor
[+]

Vitamin K2 levels are lower in multiple sclerosis patients.Mar 01, 2018

Pubmed Data : Wien Klin Wochenschr. 2018 Mar 2. Epub 2018 Mar 2. PMID: 29500722
Article Published Date : Mar 01, 2018
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Multiple Sclerosis, Vitamin K Deficiency
[+]

Vitamin K2 plus Vitamin D3 are therapeutic for the treatment of anemia and thyrombocytopenia associated wtih low/intermediate myelodysplastic syndrome. Sep 01, 2010

Pubmed Data : Leuk Res. 2010 Sep;34(9):1151-7. Epub 2010 Jun 1. PMID: 20569983
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Vitamin D, Vitamin K, Vitamin K2
Diseases : Anemia: Aplastic, Myelodysplastic Syndrome, Thrombocytopenia
[+]

Vitamin K2 status and arterial stiffness among untreated migraine patients.Nov 24, 2019

Pubmed Data : Headache. 2019 Nov 25. Epub 2019 Nov 25. PMID: 31769041
Article Published Date : Nov 24, 2019
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Arterial Hardening: Elasticity, Vitamin K Deficiency
Pharmacological Actions : Cardioprotective
[+]

Vitamin K2 supplementation in dose of 90 µg/day performed a significant effect on reducing bone loss in postmenopausal women.Feb 13, 2020

Pubmed Data : Calcif Tissue Int. 2020 Feb 14. Epub 2020 Feb 14. PMID: 32060566
Article Published Date : Feb 13, 2020
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Risk Reduction
[+]

Vitamin K2 supplementation was associated with improvement in subclinical vitamin K deficiency and arterial stiffness.Aug 31, 2017

Pubmed Data : J Am Soc Hypertens. 2017 Sep ;11(9):589-597. Epub 2017 Jul 13. PMID: 28756183
Article Published Date : Aug 31, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Arterial Hardening: Elasticity
[+]

Vitamin K2 treatment in combination with calcium supplementation increases bone mineral density in the treatment of postmenopausal osteoporosis.Apr 01, 2006

Pubmed Data : J Obstet Gynaecol Res. 2006 Apr;32(2):230-4. PMID: 16594930
Article Published Date : Apr 01, 2006
Study Type : Human Study
Additional Links
Substances : Vitamin K2, Vitamin K2: (MK-4)
Diseases : Osteoporosis
[+]

Vitamin MK-7 preserves trabecular bone structure at the tibia.Nov 30, 2016

Pubmed Data : Eur J Endocrinol. 2016 Dec ;175(6):541-549. Epub 2016 Sep 13. PMID: 27625301
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin K2: Menaquinone-7
Diseases : Osteopenia
Pharmacological Actions : Osteoprotective
[+]

vitamin Vitamin (2) works synergistically with alendronate on improving both osteocalcin carboxylation and BMD of femoral neck in postmenopausal women with osteoporosis.Jan 01, 2008

Pubmed Data : J Bone Miner Metab. 2008;26(3):260-4. Epub 2008 May 11. PMID: 18470667
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Vitamin K2
Diseases : Bone Fractures, Osteoporosis
Additional Keywords : Drug Synergy
[+]

Vitamins K2 and D3 have a protective effect on prednisolone-induced loss of bone mineral density in the lumbar spine.Jan 01, 2004

Pubmed Data : Am J Kidney Dis. 2004 Jan;43(1):53-60. PMID: 14712427
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Substances : Vitamin D, Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Corticosteroid-Induced Toxicity, Osteoporosis: Steroid-Induced
Additional Keywords : Drug: Prednisolone
[+]

The results of the present study suggested that vitamin K2 targets miR-133a to regulate osteogenesis.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 May ;15(5):2473-2480. Epub 2017 Mar 9. PMID: 28447758
Article Published Date : Apr 30, 2017
Study Type : Human In Vitro
Additional Links
Substances : Vitamin K2
Diseases : Osteonecrosis, Osteoporosis
Pharmacological Actions : MicroRNA modulator, Osteogenic
[+]

Vitamin K2 immunosuppressive effect on pediatric patients with atopic dermatitis.Nov 30, 2019

Pubmed Data : Pediatr Int. 2019 Dec ;61(12):1188-1195. Epub 2019 Dec 13. PMID: 31560147
Article Published Date : Nov 30, 2019
Study Type : Human In Vitro
Additional Links
Substances : Vitamin K2
Diseases : Atopic Dermatitis
Pharmacological Actions : Immunosuppressive Agents
[+]

Lactobacillus casei Zhang and vitamin K2 prevent intestinal tumorigenesis.Apr 10, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Apr 11 ;8(15):24719-24727. PMID: 28445967
Article Published Date : Apr 10, 2017
Study Type : Animal Study
Additional Links
Substances : Lactobacillus casei, Vitamin K2
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Menaquinone-7, a form of vitamin K2, has a stimulatory effect on bone formation in the femoral tissues of elderly female rats in vitro.Dec 01, 2002

Pubmed Data : Int J Mol Med. 2002 Dec;10(6):729-33. PMID: 12429999
Article Published Date : Dec 01, 2002
Study Type : Animal Study
Additional Links
Substances : Genistein, Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Aging, Osteopenia, Osteoporosis
[+]

Menaquinone-7, a form of vitamin K2, may prevent age-related bone loss. Jan 01, 2004

Pubmed Data : Biofactors. 2004;22(1-4):5-19. PMID: 15630245
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Aging, Osteoporosis
[+]

Vitamin K metabolism in a rat model of chronic kidney disease.Dec 31, 2016

Pubmed Data : Am J Nephrol. 2017 ;45(1):4-13. Epub 2016 Nov 16. PMID: 27846632
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin K, Vitamin K2
Diseases : Chronic Kidney Disease (CKD), Vitamin K Deficiency
Pharmacological Actions : Renoprotective
[+]

Vitamin k2 administration could improve glycemic status in type 2 diabetic rats by induction of osteocalcin gene expression.Feb 28, 2018

Pubmed Data : Nutrition. 2018 Mar ;47:33-38. Epub 2017 Oct 26. PMID: 29429532
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin K2
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Gene Expression Regulation
[+]

Vitamin K2 can inhibit calcification of aortic intima in mice.Dec 31, 2016

Pubmed Data : Vascular. 2017 Jan 1:1708538117713395. Epub 2017 Jan 1. PMID: 28587577
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin K2
Diseases : Arterial Calcification, Atherosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

Vitamin K2 improves anxiety and depression in rats with metabolic syndrome.Nov 30, 2016

Pubmed Data : Folia Med (Plovdiv). 2016 Dec 1 ;58(4):264-272. PMID: 28068285
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin K2
Diseases : Anxiety, Depression, Metabolic Syndrome X
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Vitamin K2 may be a potential therapeutic agent in the treatment of prostate cancer.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:287358. Epub 2013 Aug 24. PMID: 24062781
Article Published Date : Dec 31, 2012
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Prostate Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Apoptotic, NF-kappaB Inhibitor, prostate cancer, Vitamin K2
[+]

Vitamin K2 prevents lymphoma in drosophila.Dec 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Dec 6 ;7(1):17047. Epub 2017 Dec 6. PMID: 29213118
Article Published Date : Dec 05, 2017
Study Type : Insect Study
Additional Links
Substances : Vitamin K2
Diseases : Lymphoma
Pharmacological Actions : Chemopreventive
[+]

Vitamin K2-MK-7 improves nitric oxide-dependent endothelial function in ApoE/LDLR-/- mice.Nov 30, 2019

Pubmed Data : Vascul Pharmacol. 2019 Nov - Dec;122-123:106581. Epub 2019 Aug 14. PMID: 31421222
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Vitamin K2: Menaquinone-7
Diseases : Atherosclerosis, Endothelial Dysfunction
Pharmacological Actions : Anti-atherogenic
[+]

Vitamins K2 plus vitamin D combination could be a novel therapeutic strategy in treating diabetes-associated osteoporosis.Nov 14, 2015

Pubmed Data : Eur J Pharmacol. 2015 Nov 15 ;767:30-40. Epub 2015 Oct 8. PMID: 26452518
Article Published Date : Nov 14, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D, Vitamin K2
Diseases : Diabetic Complications, Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Natural Substance Synergy
[+]

Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate.Aug 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Infect Dis. 2020 Aug 6 ;99:286-290. Epub 2020 Aug 6. PMID: 32768697
Article Published Date : Aug 05, 2020
Study Type : Review
Additional Links
Substances : Magnesium, Vitamin D, Vitamin K2
Diseases : Coronavirus Infection
Additional Keywords : Risk Reduction
[+]

Vitamin K2 works synergistically with acyclic retinoid to suppress growth in human hepatocellular carcinoma cells.Mar 01, 2007

Pubmed Data : Cancer Sci. 2007 Mar ;98(3):431-7. PMID: 17270033
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents
Additional Keywords : Drug Synergy
[+]

A review of the effects of vitamin K2 on type 2 diabetes mellitus.Jan 31, 2018

Pubmed Data : Diabetes Res Clin Pract. 2018 Feb ;136:39-51. Epub 2017 Dec 2. PMID: 29196151
Article Published Date : Jan 31, 2018
Study Type : Review
Additional Links
Substances : Vitamin K2
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents
[+]

A review of the regulation of bone remodelling by vitamin K2.Oct 31, 2017

Pubmed Data : Oral Dis. 2017 Nov ;23(8):1021-1028. Epub 2017 Apr 5. PMID: 27976475
Article Published Date : Oct 31, 2017
Study Type : Review
Additional Links
Substances : Vitamin K2
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Clinical trials have shown that patients with osteoporosis, cardiovascular diseases and cancer can benefit from vitamin K2 supplement.Aug 02, 2015

Pubmed Data : Ugeskr Laeger. 2015 Aug 3 ;177(32):V12140700. PMID: 26321585
Article Published Date : Aug 02, 2015
Study Type : Review
Additional Links
Substances : Vitamin K2
Diseases : Cancers: All, Cardiovascular Diseases, Inflammation, Osteoporosis
Additional Keywords : Cancers: All, Cardiovascular Diseases, Inflammation, Osteoporosis, Vitamin K2
[+]

Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells.Mar 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2019 Mar 19 ;10(23):2292-2305. Epub 2019 Mar 19. PMID: 31040920
Article Published Date : Mar 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
[+]

Mechanisms of PKC-mediated enhancement of HIF-1α activity and its inhibition by vitamin K2 in hepatocellular carcinoma cells.Feb 25, 2019

Pubmed Data : Int J Mol Sci. 2019 Feb 26 ;20(5). Epub 2019 Feb 26. PMID: 30813635
Article Published Date : Feb 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Hypoxia, Liver Cancer
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Menaquinone-7, a form of vitamin K2, has an inhibitory effect on the bone-resorbing factors-induced bone resorption in elderly female rat femoral tissues in vitro.May 01, 2008

Pubmed Data : Exp Parasitol. 2008 May;119(1):74-9. Epub 2007 Dec 28. PMID: 12708750
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Osteoporosis
[+]

Protective effects of vitamin K2 on 6-OHDA-induced apoptosis in PC12 cells through modulation bax and caspase-3 activation.Nov 30, 2019

Pubmed Data : Mol Biol Rep. 2019 Dec ;46(6):5777-5783. Epub 2019 Aug 7. PMID: 31392537
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Research indicates that vitamin K2 intake reduces coronary heart disease events.Oct 01, 2010

Pubmed Data : Maturitas. 2010 Oct;67(2):121-8. Epub 2010 Jun 17. PMID: 20850029
Article Published Date : Oct 01, 2010
Study Type : Review
Additional Links
Substances : Vitamin K2
Diseases : Coronary Artery Disease
[+]

Supplementation with phytonadione (Vitamin K1) and menaquinone (Vitamin K2) , particularly menaquinone-4, is associated with increased BMD and reduced fracture incidence. Oct 01, 2008

Pubmed Data : Clin Calcium. 2008 Oct;18(10):1476-82. PMID: 18830045
Article Published Date : Oct 01, 2008
Study Type : Review
Additional Links
Substances : Vitamin K, Vitamin K2, Vitamin K2: (MK-4)
Diseases : Bone Fractures, Osteoporosis
[+]

The combination of vitamin K2 and cotylenin A has therapeutic value in the treatment of acute myeloid leukemia.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2015 Aug ;47(2):473-80. Epub 2015 Jun 4. PMID: 26046133
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Gene Expression Regulation
[+]

The intake of natto, an excellent source of vitamin K2, may reduce bone fracture risk. Sep 01, 2009

Pubmed Data : Clin Calcium. 2009 Sep;19(9):1362-9. PMID: 19721210
Article Published Date : Sep 01, 2009
Study Type : Review
Additional Links
Substances : Natto , Vitamin K2, Vitamin K2: Menaquinone-7
Diseases : Bone Fractures
[+]

This study shows the real-time effects of VK derivatives on breast cancer cells and suggests that dietary factors may be an important consideration for patients.Jul 31, 2015

Pubmed Data : Nutr Res. 2015 Aug ;35(8):736-43. Epub 2015 May 30. PMID: 26082424
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
Additional Keywords : Dose Response
[+]

Vitamin D, unopposed by sufficient vitamin K (and possibly vitamin A), may cause hypercalcemia and other metabolic imbalances.Jan 01, 2007

Pubmed Data : Med Hypotheses. 2007;68(5):1026-34. Epub 2006 Dec 4. PMID: 17145139
Article Published Date : Jan 01, 2007
Study Type : Commentary
Additional Links
Substances : Vitamin A, Vitamin D, Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Hypercalcemia
Additional Keywords : Nutrient Interdependence
[+]

Vitamin K has been shown to suppress the growth of liver cancer cells.Oct 31, 2015

Pubmed Data : Clin Calcium. 2015 Nov ;25(11):1645-51. PMID: 26503869
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic
Additional Keywords : Antineoplastic Agents, Apoptotic, Chemotherapeutic, liver cancer, Natural Substance/Drug Synergy, Vitamin K2
[+]

Vitamin K supplementation may be useful for a number of chronic conditions.Dec 31, 2016

Pubmed Data : J Nutr Metab. 2017 ;2017:6254836. Epub 2017 Jun 18. PMID: 28698808
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Vitamin K, Vitamin K2
Diseases : Arterial Calcification, Arthritis, Cancers: All, Diabetes Mellitus: Type 2, Osteoporosis
[+]

Vitamin K(2) serves as a mitochondrial electron carrier, helping to maintain normal ATP production in mitochondrial dysfunction.Jun 07, 2012

Pubmed Data : Science. 2012 Jun 8 ;336(6086):1306-10. Epub 2012 May 10. PMID: 22582012
Article Published Date : Jun 07, 2012
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Mitochondrial Diseases, Mitochondrial Dysfunction
[+]

Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation.Jan 01, 2011

Pubmed Data : Oncol Rep. 2011 Jan;25(1):159-66. PMID: 21109972
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K, Vitamin K2
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Drug: 5-flourouracil, Drug Synergy
[+]

Vitamin K2 can be an interesting strategy in benefitting bone and vascular health.Dec 11, 2017

Pubmed Data : Crit Rev Food Sci Nutr. 2017 Dec 12 ;57(18):3959-3970. PMID: 27437760
Article Published Date : Dec 11, 2017
Study Type : Review
Additional Links
Substances : Vitamin K, Vitamin K2
Diseases : Arterial Calcification, Osteoporosis
[+]

Vitamin K2 could be a promising agent for the prevention and treatment of glucocorticoids induced osteoporosis and osteonecrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 Jan ;39(1):160-166. Epub 2016 Dec 1. PMID: 27909721
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Osteonecrosis, Osteoporosis
[+]

Vitamin K2 has a dual mode of action with therapeutic potential in fracture prevention and proper bone mineral density. Jan 01, 2011

Pubmed Data : Int J Mol Med. 2011 Jan;27(1):3-14. Epub 2010 Nov 11. PMID: 21072493
Article Published Date : Jan 01, 2011
Study Type : Review
Additional Links
Substances : Vitamin K2, Vitamin K2: Menaquinone-7
Diseases : Bone Fractures, Osteoporosis
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Vitamin K2 has immunomodulatory activities.Feb 28, 2018

Pubmed Data : Oral Dis. 2018 Mar ;24(1-2):67-71. PMID: 29480629
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Osteoporosis
Pharmacological Actions : Immunomodulatory
[+]

Vitamin K2 induces apoptosis in bladder cancer cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(8):e0161886. Epub 2016 Aug 29. PMID: 27570977
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Apoptotic, bladder cancer, Cancer, Vitamin K, Vitamin K2
[+]

Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines.Oct 16, 2019

Pubmed Data : Breast Cancer. 2019 Oct 17. Epub 2019 Oct 17. PMID: 31625014
Article Published Date : Oct 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Vitamin K2 targets castration-resistant prostate cancer cell-line by activating apoptosis signalling.Feb 08, 2018

Pubmed Data : Food Chem Toxicol. 2018 Feb 9 ;115:218-227. Epub 2018 Feb 9. PMID: 29432837
Article Published Date : Feb 08, 2018
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic
[+]

Vitamin K2-derived compounds inhibit growth in radioresistant cancer cells.Dec 31, 2009

Pubmed Data : Kobe J Med Sci. 2010 ;56(2):E38-49. Epub 2010 Sep 28. PMID: 21063145
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2
Diseases : Cancers: Radiation-Resistant
Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor, Radiosensitizer
[+]

Vtamin K2 may improve bone quality in type 2 diabetes.Mar 01, 2011

Pubmed Data : Nutr Rev. 2011 Mar;69(3):162-7. Epub 2011 Feb 14. PMID: 21348880
Article Published Date : Mar 01, 2011
Study Type : Review
Additional Links
Substances : Vitamin K2
Diseases : Diabetes: Bone Quality & Density, Diabetes Mellitus: Type 2, Osteoporosis

Copyright: lisaanfisa / 123RF Stock Photo

Vitamin K2 Related Articles

Protect Your Bones With 8 Natural Osteoprotectives
Written by Dr. Diane Fulton
Your bones support your entire body. Isn’t it time to find natural alternatives to strengthen them?
Is Coronavirus Contagious?
Written by Sally Fallon Morell
From face masks to social distancing, from antivirals to vaccines, these measures are predicated on the assumption that tiny viruses can cause serious illness, but is coronavirus contagious?
Toxic...and Don't Know?
Written by Capt. Randall
Ever since humans discovered fire, our activities have been releasing a "dog's breakfast" of unnatural chemistry. The list has grown to well over 75,000 free elements, compounds and pharmaceuticals. Many of these are acidic, electron-hungry oxidants and free radical generators.
Dietary Supplements: Harmful or Essential? Cutting Through the Unrelenting Rhetoric
Written by Glenn Sabin & Lise Alschuler, ND, FABNO
Are dietary supplements useless or beneficial?
Osteoporosis Is Scurvy of the Bone, Not Calcium Deficiency
Written by Suzanne Humphries, MD
It saddens me to see older women diagnosed with "osteopenia" or "osteoporosis" listening to their doctors and taking supplemental calcium and even problematic drugs called bisphosphonates. These are irrational, dogmatic, harmful approaches to the problem of degrading bone as we age
The Three Pillars of Radiant Health
Written by Louise Habakus
These 3 Pillars of Radiant Health can serve as guideposts for many health issues that may come up: protecting your microbiota, changing how and what you eat, and choosing non-toxic subsitutes.
Vitamin K2 Effective in Rheumatoid Arthritis
Written by Dr. Michael Murray
Nutritional Risk Factors in Suicide: How Vitamin D Can Help
Written by GMI Reporter
While suicide has many different causes and risk factors, many recent studies have suggested that low sunshine exposure and vitamin D deficiency may be a major factor in suicide
Myocarditis: Once Rare, Now Common
Written by Orthomolecular News Service
The scientific literature indicates that myocarditis is occurring quite frequently in patients harboring the chronic presence of the COVID-related spike protein

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.